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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gruenerite
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Accession:CHEBI:46679 term browser browse the term
Synonyms:related_synonym: Fe7Si8O22(OH)2;   Formula=Fe7H2O24Si8;   Gruenerit;   Grunerite
 xref: CAS:14567-61-4


show annotations for term's descendants           Sort by:
amosite asbestos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatk apoptosis-associated tyrosine kinase decreases methylation ISO Asbestos, Amosite results in decreased methylation of AATK promoter CTD PMID:29626692 NCBI chr10:105,290,752...105,327,219
Ensembl chr10:105,291,585...105,327,112 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases methylation ISO Asbestos, Amosite results in increased methylation of ABCG2 promoter CTD PMID:29626692 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Abr ABR activator of RhoGEF and GTPase decreases methylation ISO Asbestos, Amosite results in decreased methylation of ABR promoter CTD PMID:29626692 NCBI chr10:61,262,516...61,461,331
Ensembl chr10:61,262,516...61,461,505 		JBrowse link
G Acod1 aconitate decarboxylase 1 decreases expression ISO Asbestos, Amosite results in decreased expression of ACOD1 mRNA CTD PMID:23917077 NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases activity ISO Asbestos, Amosite results in increased activity of AKT1 protein CTD PMID:29112861 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ankrd11 ankyrin repeat domain containing 11 decreases methylation ISO Asbestos, Amosite results in decreased methylation of ANKRD11 promoter CTD PMID:29626692 NCBI chr19:50,940,284...51,098,962
Ensembl chr19:50,940,299...51,098,962 		JBrowse link
G Ankrd52 ankyrin repeat domain 52 decreases methylation ISO Asbestos, Amosite results in decreased methylation of ANKRD52 promoter CTD PMID:29626692 NCBI chr 7:806,829...820,481
Ensembl chr 7:806,767...820,481 		JBrowse link
G Ano1 anoctamin 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of ANO1 promoter CTD PMID:29626692 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069 		JBrowse link
G Arhgef17 Rho guanine nucleotide exchange factor 17 decreases methylation ISO Asbestos, Amosite results in decreased methylation of ARHGEF17 promoter CTD PMID:29626692 NCBI chr 1:155,230,607...155,290,163
Ensembl chr 1:155,233,168...155,290,498 		JBrowse link
G Arhgef18 Rho/Rac guanine nucleotide exchange factor 18 decreases methylation ISO Asbestos, Amosite results in decreased methylation of ARHGEF18 promoter CTD PMID:29626692 NCBI chr12:1,395,035...1,503,082
Ensembl chr12:1,395,088...1,503,081 		JBrowse link
G Arhgef4 Rho guanine nucleotide exchange factor 4 decreases methylation ISO Asbestos, Amosite results in decreased methylation of ARHGEF4 promoter CTD PMID:29626692 NCBI chr 9:36,861,800...37,005,079
Ensembl chr 9:36,861,835...37,005,075 		JBrowse link
G Arrdc3 arrestin domain containing 3 increases methylation ISO Asbestos, Amosite results in increased methylation of ARRDC3 promoter CTD PMID:29626692 NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978 		JBrowse link
G Atg16l2 autophagy related 16-like 2 increases methylation ISO Asbestos, Amosite results in increased methylation of ATG16L2 promoter CTD PMID:29626692 NCBI chr 1:155,687,386...155,703,419
Ensembl chr 1:155,684,564...155,703,420 		JBrowse link
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit decreases expression ISO Asbestos, Amosite results in decreased expression of ATP12A mRNA CTD PMID:23917077 NCBI chr15:30,443,571...30,468,229
Ensembl chr15:30,443,571...30,468,229 		JBrowse link
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 increases expression ISO Asbestos, Amosite results in increased expression of ATP2C2 mRNA CTD PMID:23917077 NCBI chr19:47,754,120...47,811,369
Ensembl chr19:47,754,120...47,811,368 		JBrowse link
G Aurkc aurora kinase C decreases methylation ISO Asbestos, Amosite results in decreased methylation of AURKC promoter CTD PMID:29626692 NCBI chr 1:66,843,653...66,849,775
Ensembl chr 1:66,843,653...66,864,386 		JBrowse link
G Barx1 BARX homeobox 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of BARX1 promoter CTD PMID:29626692 NCBI chr17:15,990,412...15,993,887
Ensembl chr17:15,990,412...15,993,887 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects localization		 ISO pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of BAX protein] CTD PMID:16357363 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO BCL2L1 protein inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]; BCL2L1 protein inhibits the reaction [Asbestos, Amosite results in increased expression of XBP1 protein alternative form] CTD PMID:23885834 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Best1 bestrophin 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of BEST1 promoter CTD PMID:29626692 NCBI chr 1:206,629,340...206,646,085
Ensembl chr 1:206,629,500...206,646,063 		JBrowse link
G Best4 bestrophin 4 decreases methylation ISO Asbestos, Amosite results in decreased methylation of BEST4 promoter CTD PMID:29626692 NCBI chr 5:130,622,194...130,629,045
Ensembl chr 5:130,623,438...130,627,099 		JBrowse link
G Bhlha9 basic helix-loop-helix family, member a9 decreases expression ISO Asbestos, Amosite results in decreased expression of BHLHA9 mRNA CTD PMID:23917077 NCBI chr10:61,513,609...61,514,730
Ensembl chr10:61,513,609...61,514,301 		JBrowse link
G Bsx brain specific homeobox decreases methylation ISO Asbestos, Amosite results in decreased methylation of BSX promoter CTD PMID:29626692 NCBI chr 8:41,254,105...41,257,861
Ensembl chr 8:41,254,105...41,257,861 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase increases expression ISO Asbestos, Amosite results in increased expression of BUB1 mRNA CTD PMID:23917077 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases methylation ISO Asbestos, Amosite results in decreased methylation of CAMK4 promoter CTD PMID:29626692 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO Asbestos, Amosite results in increased activity of CASP3 protein
Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein]; Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein]		 CTD PMID:11329530 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 EXP
ISO		 pifithrin inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]; Deferoxamine inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]; Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]; Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]		 CTD PMID:12540492 PMID:14766669 PMID:16357363 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Asbestos, Amosite results in increased activity of PARP1 protein] CTD PMID:11217149 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdh16 cadherin 16 decreases methylation ISO Asbestos, Amosite results in decreased methylation of CDH16 promoter CTD PMID:29626692 NCBI chr19:360,824...371,008
Ensembl chr19:360,824...371,007 		JBrowse link
G Cdh22 cadherin 22 decreases methylation ISO Asbestos, Amosite results in decreased methylation of CDH22 promoter CTD PMID:29626692 NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:153,845,787...153,970,588 		JBrowse link
G Cdh3 cadherin 3 decreases methylation ISO Asbestos, Amosite results in decreased methylation of CDH3 promoter CTD PMID:29626692 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084 		JBrowse link
G Cdh6 cadherin 6 decreases methylation ISO Asbestos, Amosite results in decreased methylation of CDH6 promoter CTD PMID:29626692 NCBI chr 2:62,079,139...62,225,298
Ensembl chr 2:62,079,137...62,225,228 		JBrowse link
G Cdh7 cadherin 7 decreases methylation ISO Asbestos, Amosite results in decreased methylation of CDH7 promoter CTD PMID:29626692 NCBI chr13:26,672,058...26,821,571
Ensembl chr13:26,672,484...26,819,846 		JBrowse link
G Cdk18 cyclin-dependent kinase 18 decreases methylation ISO Asbestos, Amosite results in decreased methylation of CDK18 promoter CTD PMID:29626692 NCBI chr13:43,555,597...43,582,210
Ensembl chr13:43,556,748...43,588,525 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases methylation ISO Asbestos, Amosite results in decreased methylation of CDKN1A gene CTD PMID:30990028 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases methylation
decreases expression
multiple interactions		 ISO Asbestos, Amosite results in increased methylation of CDKN2A exon
Asbestos, Amosite results in decreased expression of CDKN2A mRNA; Asbestos, Amosite results in decreased expression of CDKN2A mRNA alternative form; Asbestos, Amosite results in decreased expression of CDKN2A protein; Asbestos, Amosite results in decreased expression of CDKN2A protein alternative form
Asbestos, Amosite results in increased susceptibility to [NF2 protein mutant form co-treated with CDKN2A protein mutant form co-treated with TRP53 protein mutant form]		 CTD PMID:29112861 PMID:37441092 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdx2 caudal type homeo box 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of CDX2 promoter CTD PMID:29626692 NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142 		JBrowse link
G Cmss1 cms1 ribosomal small subunit homolog decreases expression ISO Asbestos, Amosite results in decreased expression of CMSS1 mRNA CTD PMID:23917077 NCBI chr11:42,934,390...43,232,624
Ensembl chr11:42,934,440...43,232,624 		JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 increases methylation ISO Asbestos, Amosite results in increased methylation of CNOT9 promoter CTD PMID:29626692 NCBI chr 9:76,084,269...76,109,111
Ensembl chr 9:76,084,334...76,109,100 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression		 EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Asbestos, Amosite results in increased expression of COL1A1 mRNA]; Deferoxamine inhibits the reaction [Asbestos, Amosite results in increased expression of COL1A1 mRNA]; Iron promotes the reaction [Asbestos, Amosite results in increased expression of COL1A1 mRNA]; tetramethylthiourea inhibits the reaction [Asbestos, Amosite results in increased expression of COL1A1 mRNA] CTD PMID:11306436 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Asbestos, Amosite results in increased expression of CXCL1 protein CTD PMID:27083413 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxxc1 CXXC finger protein 1 increases methylation ISO Asbestos, Amosite results in increased methylation of CXXC1 promoter CTD PMID:29626692 NCBI chr18:67,813,185...67,818,556
Ensembl chr18:67,813,206...67,818,551 		JBrowse link
G Dclk1 doublecortin-like kinase 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of DCLK1 promoter CTD PMID:29626692 NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Asbestos, Amosite results in increased expression of DDIT3 mRNA CTD PMID:23885834 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dennd3 DENN domain containing 3 increases methylation ISO Asbestos, Amosite results in increased methylation of DENND3 promoter CTD PMID:29626692 NCBI chr 7:105,415,870...105,473,583
Ensembl chr 7:105,415,677...105,473,592 		JBrowse link
G Dlx4 distal-less homeobox 4 decreases methylation ISO Asbestos, Amosite results in decreased methylation of DLX4 promoter CTD PMID:29626692 NCBI chr10:80,085,037...80,090,434
Ensembl chr10:80,085,465...80,090,456 		JBrowse link
G Dmpk DM1 protein kinase decreases methylation ISO Asbestos, Amosite results in decreased methylation of DMPK promoter CTD PMID:29626692 NCBI chr 1:78,730,255...78,740,585
Ensembl chr 1:78,730,275...78,740,593 		JBrowse link
G Egfr epidermal growth factor receptor increases expression
decreases phosphorylation		 EXP
ISO		 Asbestos, Amosite results in increased expression of EGFR mRNA
Asbestos, Amosite results in decreased phosphorylation of EGFR protein		 CTD PMID:15626777 PMID:22251266 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Emx1 empty spiracles homeobox 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of EMX1 promoter CTD PMID:29626692 NCBI chr 4:117,725,148...117,741,616
Ensembl chr 4:117,725,155...117,741,613 		JBrowse link
G En2 engrailed homeobox 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of EN2 promoter CTD PMID:29626692 NCBI chr 4:7,221,096...7,226,943
Ensembl chr 4:7,221,096...7,226,943 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression
multiple interactions		 ISO
EXP		 Asbestos, Amosite results in increased expression of ERN1 mRNA; Asbestos, Amosite results in increased expression of ERN1 protein
4-phenylbutyric acid inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]; BCL2L1 protein inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]; EUK-134 inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]		 CTD PMID:23885834 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of ERN2 promoter CTD PMID:29626692 NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289 		JBrowse link
G Esyt3 extended synaptotagmin 3 increases expression ISO Asbestos, Amosite results in increased expression of ESYT3 mRNA CTD PMID:23917077 NCBI chr 8:99,870,418...99,917,298
Ensembl chr 8:99,871,149...99,917,232 		JBrowse link
G Evx1 even-skipped homeobox 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of EVX1 promoter CTD PMID:29626692 NCBI chr 4:81,416,590...81,420,967
Ensembl chr 4:81,416,590...81,420,967 		JBrowse link
G Evx2 even-skipped homeobox 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of EVX2 promoter CTD PMID:29626692 NCBI chr 3:59,558,197...59,562,267
Ensembl chr 3:59,558,197...59,561,872 		JBrowse link
G Fam72a family with sequence similarity 72, member A increases methylation ISO Asbestos, Amosite results in increased methylation of FAM72A promoter CTD PMID:29626692 NCBI chr13:42,967,701...42,979,083
Ensembl chr13:42,967,578...42,984,208 		JBrowse link
G Farp1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of FARP1 promoter CTD PMID:29626692 NCBI chr15:98,124,304...98,363,299
Ensembl chr15:98,182,329...98,363,299 		JBrowse link
G Fat3 FAT atypical cadherin 3 decreases methylation ISO Asbestos, Amosite results in decreased methylation of FAT3 promoter CTD PMID:29626692 NCBI chr 8:12,691,470...13,274,336
Ensembl chr 8:12,694,019...13,273,135 		JBrowse link
G Fcsk fucose kinase increases methylation ISO Asbestos, Amosite results in increased methylation of FCSK promoter CTD PMID:29626692 NCBI chr19:38,849,130...38,874,497
Ensembl chr19:38,854,762...38,874,418 		JBrowse link
G Foxd2 forkhead box D2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of FOXD2 promoter CTD PMID:29626692 NCBI chr 5:128,427,986...128,430,709
Ensembl chr 5:128,429,020...128,430,504 		JBrowse link
G Foxe3 forkhead box E3 decreases methylation ISO Asbestos, Amosite results in decreased methylation of FOXE3 promoter CTD PMID:29626692 NCBI chr 5:128,444,912...128,446,494
Ensembl chr 5:128,445,594...128,446,454 		JBrowse link
G Foxg1 forkhead box G1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of FOXG1 promoter CTD PMID:29626692 NCBI chr 6:66,674,797...66,677,611
Ensembl chr 6:66,666,587...66,678,607 		JBrowse link
G Foxi1 forkhead box I1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of FOXI1 promoter CTD PMID:29626692 NCBI chr10:18,806,292...18,810,231
Ensembl chr10:18,806,308...18,810,231 		JBrowse link
G Foxi2 forkhead box I2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of FOXI2 promoter CTD PMID:29626692 NCBI chr 1:190,222,857...190,226,657
Ensembl chr 1:190,222,703...190,226,433 		JBrowse link
G Foxk1 forkhead box K1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of FOXK1 promoter CTD PMID:29626692 NCBI chr12:12,110,119...12,175,089
Ensembl chr12:12,115,950...12,175,089 		JBrowse link
G Foxl1 forkhead box L1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of FOXL1 promoter CTD PMID:29626692 NCBI chr19:49,197,269...49,200,682
Ensembl chr19:49,197,400...49,198,425 		JBrowse link
G Foxn3 forkhead box N3 decreases methylation ISO Asbestos, Amosite results in decreased methylation of FOXN3 promoter CTD PMID:29626692 NCBI chr 6:118,462,018...118,842,442
Ensembl chr 6:118,466,025...118,842,401 		JBrowse link
G Fxyd1 FXYD domain-containing ion transport regulator 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of FXYD1 promoter CTD PMID:29626692 NCBI chr 1:86,287,163...86,291,478
Ensembl chr 1:86,287,165...86,291,278 		JBrowse link
G Fxyd6 FXYD domain-containing ion transport regulator 6 decreases methylation ISO Asbestos, Amosite results in decreased methylation of FXYD6 promoter CTD PMID:29626692 NCBI chr 8:45,679,054...45,705,958
Ensembl chr 8:45,678,885...45,705,958 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity
multiple interactions		 ISO Asbestos, Amosite results in decreased activity of G6PD protein
Glutathione inhibits the reaction [Asbestos, Amosite results in decreased activity of G6PD protein]		 CTD PMID:14613721 PMID:18370412 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gak cyclin G associated kinase decreases methylation ISO Asbestos, Amosite results in decreased methylation of GAK promoter CTD PMID:29626692 NCBI chr14:1,089,853...1,164,098
Ensembl chr14:1,089,866...1,216,398 		JBrowse link
G Gsc2 goosecoid homeobox 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of GSC2 promoter CTD PMID:29626692 NCBI chr11:83,070,784...83,075,874
Ensembl chr11:83,072,138...83,074,126 		JBrowse link
G Gtf2ird1 GTF2I repeat domain containing 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of GTF2IRD1 promoter CTD PMID:29626692 NCBI chr12:22,254,113...22,361,052
Ensembl chr12:22,254,221...22,361,040 		JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase increases activity ISO Asbestos, Amosite results in increased activity of HCK protein CTD PMID:29112861 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693 		JBrowse link
G Hlx H2.0-like homeobox decreases methylation ISO Asbestos, Amosite results in decreased methylation of HLX promoter CTD PMID:29626692 NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750 		JBrowse link
G Hoxa10 homeobox A10 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXA10 promoter CTD PMID:29626692 NCBI chr 4:81,331,591...81,340,878
Ensembl chr 4:81,331,591...81,340,919 		JBrowse link
G Hoxa11 homeobox A11 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXA11 promoter CTD PMID:29626692 NCBI chr 4:81,342,527...81,346,189
Ensembl chr 4:81,342,528...81,346,232 		JBrowse link
G Hoxa13 homeo box A13 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXA13 promoter CTD PMID:29626692 NCBI chr 4:81,358,956...81,361,091
Ensembl chr 4:81,358,956...81,361,091 		JBrowse link
G Hoxa3 homeobox A3 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXA3 promoter CTD PMID:29626692 NCBI chr 4:81,269,243...81,313,218
Ensembl chr 4:81,269,243...81,313,218 		JBrowse link
G Hoxa4 homeo box A4 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXA4 promoter CTD PMID:29626692 NCBI chr 4:81,289,677...81,291,685
Ensembl chr 4:81,289,682...81,291,685 		JBrowse link
G Hoxa6 homeobox A6 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXA6 promoter CTD PMID:29626692 NCBI chr 4:81,304,918...81,313,184
Ensembl chr 4:81,306,407...81,308,850 		JBrowse link
G Hoxa9 homeobox A9 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXA9 promoter CTD PMID:29626692 NCBI chr 4:81,323,235...81,329,344
Ensembl chr 4:81,323,382...81,326,358 		JBrowse link
G Hoxb1 homeo box B1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXB1 promoter CTD PMID:29626692 NCBI chr10:81,331,507...81,332,928
Ensembl chr10:81,331,507...81,332,836 		JBrowse link
G Hoxb3 homeo box B3 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXB3 promoter CTD PMID:29626692 NCBI chr10:81,258,739...81,314,134
Ensembl chr10:81,299,357...81,313,107 		JBrowse link
G Hoxb5 homeo box B5 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXB5 promoter CTD PMID:29626692 NCBI chr10:81,269,372...81,271,580
Ensembl chr10:81,269,372...81,271,580 		JBrowse link
G Hoxb6 homeo box B6 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXB6 promoter CTD PMID:29626692 NCBI chr10:81,258,726...81,267,458
Ensembl chr10:81,265,056...81,267,449 		JBrowse link
G Hoxb7 homeo box B7 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXB7 promoter CTD PMID:29626692 NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034 		JBrowse link
G Hoxb8 homeo box B8 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXB8 promoter CTD PMID:29626692 NCBI chr10:81,248,313...81,251,261
Ensembl chr10:81,248,887...81,250,638 		JBrowse link
G Hoxb9 homeo box B9 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXB9 promoter CTD PMID:29626692 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818 		JBrowse link
G Hoxc11 homeobox C11 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXC11 promoter CTD PMID:29626692 NCBI chr 7:134,091,224...134,094,738
Ensembl chr 7:134,091,552...134,094,738 		JBrowse link
G Hoxc4 homeo box C4 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXC4 promoter CTD PMID:29626692 NCBI chr 7:134,135,279...134,173,133
Ensembl chr 7:134,170,591...134,173,133 		JBrowse link
G Hoxc5 homeo box C5 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXC5 promoter CTD PMID:29626692 NCBI chr 7:134,150,988...134,154,410
Ensembl chr 7:134,150,988...134,154,410 		JBrowse link
G Hoxd11 homeobox D11 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXD11 promoter CTD PMID:29626692 NCBI chr 3:59,584,840...59,587,257
Ensembl chr 3:59,585,039...59,586,783 		JBrowse link
G Hoxd12 homeo box D12 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXD12 promoter CTD PMID:29626692 NCBI chr 3:59,577,677...59,578,798
Ensembl chr 3:59,577,677...59,578,798 		JBrowse link
G Hoxd4 homeo box D4 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXD4 promoter CTD PMID:29626692 NCBI chr 3:59,614,464...59,634,042
Ensembl chr 3:59,614,464...59,631,528 		JBrowse link
G Hoxd8 homeobox D8 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HOXD8 promoter CTD PMID:29626692 NCBI chr 3:59,607,793...59,610,359
Ensembl chr 3:59,607,996...59,610,361 		JBrowse link
G Hpcal1 hippocalcin-like 1 increases methylation ISO Asbestos, Amosite results in increased methylation of HPCAL1 gene CTD PMID:32062310 NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687 		JBrowse link
G Hsf4 heat shock transcription factor 4 decreases methylation ISO Asbestos, Amosite results in decreased methylation of HSF4 promoter CTD PMID:29626692 NCBI chr19:33,147,755...33,153,479
Ensembl chr19:33,147,755...33,153,479 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Asbestos, Amosite results in increased expression of HSPA5 mRNA; Asbestos, Amosite results in increased expression of HSPA5 protein CTD PMID:23885834 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion		 EXP
ISO		 Asbestos, Amosite results in increased expression of IL1B protein
Asbestos, Amosite results in increased secretion of IL1B protein
Asbestos, Amosite results in increased expression of IL1B mRNA		 CTD PMID:8473757 PMID:27083413 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression ISO Asbestos, Amosite results in increased expression of IL6 mRNA CTD PMID:29112861 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Iqub IQ motif and ubiquitin domain containing increases methylation ISO Asbestos, Amosite results in increased methylation of IQUB promoter CTD PMID:29626692 NCBI chr 4:52,931,768...52,993,795
Ensembl chr 4:52,931,767...52,993,834 		JBrowse link
G Irx6 iroquois homeobox 6 decreases methylation ISO Asbestos, Amosite results in decreased methylation of IRX6 promoter CTD PMID:29626692 NCBI chr19:14,330,440...14,336,403
Ensembl chr19:14,330,440...14,336,403 		JBrowse link
G Isl2 ISL LIM homeobox 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of ISL2 promoter CTD PMID:29626692 NCBI chr 8:55,923,805...55,928,790
Ensembl chr 8:55,923,805...55,928,790 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 increases expression ISO Asbestos, Amosite results in increased expression of KCNJ6 mRNA CTD PMID:23917077 NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
G Klf3 KLF transcription factor 3 increases methylation ISO Asbestos, Amosite results in increased methylation of KLF3 gene CTD PMID:32062310 NCBI chr14:43,474,767...43,505,801
Ensembl chr14:43,474,767...43,497,209 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 increases methylation ISO Asbestos, Amosite results in increased methylation of KLK3 gene CTD PMID:32062310 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Lbx2 ladybird homeobox 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of LBX2 promoter CTD PMID:29626692 NCBI chr 4:115,591,974...115,593,859
Ensembl chr 4:115,591,974...115,594,132 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase increases activity ISO Asbestos, Amosite results in increased activity of LCK protein CTD PMID:29112861 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Lhx2 LIM homeobox 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of LHX2 promoter CTD PMID:29626692 NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908 		JBrowse link
G Lhx3 LIM homeobox 3 decreases methylation ISO Asbestos, Amosite results in decreased methylation of LHX3 promoter CTD PMID:29626692 NCBI chr 3:9,026,432...9,035,122
Ensembl chr 3:9,027,425...9,034,480 		JBrowse link
G Lhx6 LIM homeobox 6 decreases methylation ISO Asbestos, Amosite results in decreased methylation of LHX6 promoter CTD PMID:29626692 NCBI chr 3:19,432,439...19,456,268
Ensembl chr 3:19,433,494...19,456,061 		JBrowse link
G Lhx8 LIM homeobox 8 decreases methylation ISO Asbestos, Amosite results in decreased methylation of LHX8 promoter CTD PMID:29626692 NCBI chr 2:243,244,958...243,269,624
Ensembl chr 2:243,244,961...243,269,416 		JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha decreases methylation ISO Asbestos, Amosite results in decreased methylation of LMX1A promoter CTD PMID:29626692 NCBI chr13:79,834,614...79,978,253
Ensembl chr13:79,835,019...79,978,253 		JBrowse link
G Lsm14b LSM family member 14B increases methylation ISO Asbestos, Amosite results in increased methylation of LSM14B promoter CTD PMID:29626692 NCBI chr 3:167,125,633...167,136,417
Ensembl chr 3:167,125,628...167,136,432 		JBrowse link
G Ltk leukocyte receptor tyrosine kinase decreases methylation ISO Asbestos, Amosite results in decreased methylation of LTK promoter CTD PMID:29626692 NCBI chr 3:106,734,675...106,741,552
Ensembl chr 3:106,734,676...106,743,369 		JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 decreases methylation ISO Asbestos, Amosite results in decreased methylation of MAP3K12 promoter CTD PMID:29626692 NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789 		JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 decreases methylation ISO Asbestos, Amosite results in decreased methylation of MAP3K6 promoter CTD PMID:29626692 NCBI chr 5:145,440,126...145,452,213
Ensembl chr 5:145,440,346...145,452,212 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
increases activity		 EXP
ISO		 Asbestos, Amosite results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Amosite results in increased phosphorylation of MAPK1 protein]; Iron promotes the reaction [Asbestos, Amosite results in increased phosphorylation of MAPK1 protein]
Asbestos, Amosite results in increased activity of MAPK1 protein		 CTD PMID:11306436 PMID:29112861 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
increases activity		 EXP
ISO		 Asbestos, Amosite results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Amosite results in increased phosphorylation of MAPK3 protein]; Iron promotes the reaction [Asbestos, Amosite results in increased phosphorylation of MAPK3 protein]
Asbestos, Amosite results in increased activity of MAPK3 protein		 CTD PMID:11306436 PMID:29112861 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcf2l MCF.2 cell line derived transforming sequence-like decreases methylation ISO Asbestos, Amosite results in decreased methylation of MCF2L promoter CTD PMID:29626692 NCBI chr16:76,507,133...76,652,893
Ensembl chr16:76,507,133...76,652,733 		JBrowse link
G Mcm3ap minichromosome maintenance complex component 3 associated protein increases methylation ISO Asbestos, Amosite results in increased methylation of MCM3AP promoter CTD PMID:29626692 NCBI chr20:12,127,570...12,165,165
Ensembl chr20:12,127,570...12,165,165 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of MKNK2 promoter CTD PMID:29626692 NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827 		JBrowse link
G Mroh3 maestro heat-like repeat family member 3 increases expression ISO Asbestos, Amosite results in increased expression of MROH3 mRNA CTD PMID:23917077 NCBI chr13:47,630,004...47,665,461
Ensembl chr13:47,630,003...47,665,394 		JBrowse link
G Mylk3 myosin light chain kinase 3 decreases methylation ISO Asbestos, Amosite results in decreased methylation of MYLK3 promoter CTD PMID:29626692 NCBI chr19:21,685,085...21,743,587
Ensembl chr19:21,691,929...21,742,954 		JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor multiple interactions ISO Asbestos, Amosite results in increased susceptibility to [NF2 protein mutant form co-treated with CDKN2A protein mutant form co-treated with TRP53 protein mutant form] CTD PMID:37441092 NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667 		JBrowse link
G Nfix nuclear factor I X decreases methylation ISO Asbestos, Amosite results in decreased methylation of NFIX promoter CTD PMID:29626692 NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265 		JBrowse link
G Nfkbid NFKB inhibitor delta decreases methylation ISO Asbestos, Amosite results in decreased methylation of NFKBID promoter CTD PMID:29626692 NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447 		JBrowse link
G Ngef neuronal guanine nucleotide exchange factor decreases methylation ISO Asbestos, Amosite results in decreased methylation of NGEF promoter CTD PMID:29626692 NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914 		JBrowse link
G Nkx6-2 NK6 homeobox 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of NKX6-2 promoter CTD PMID:29626692 NCBI chr 1:194,380,149...194,383,533
Ensembl chr 1:194,381,975...194,383,515 		JBrowse link
G Noto notochord homeobox decreases methylation ISO Asbestos, Amosite results in decreased methylation of NOTO promoter CTD PMID:29626692 NCBI chr 4:117,961,163...117,965,402
Ensembl chr 4:117,961,163...117,965,402 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 decreases expression ISO Asbestos, Amosite results in decreased expression of OAS3 mRNA CTD PMID:23917077 NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781 		JBrowse link
G Onecut1 one cut homeobox 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of ONECUT1 promoter CTD PMID:29626692 NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277 		JBrowse link
G Otp orthopedia homeobox decreases methylation ISO Asbestos, Amosite results in decreased methylation of OTP promoter CTD PMID:29626692 NCBI chr 2:26,108,158...26,116,359
Ensembl chr 2:26,108,163...26,116,359 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity		 ISO 3-aminobenzamide inhibits the reaction [Asbestos, Amosite results in increased activity of PARP1 protein]; [Smoke analog co-treated with Asbestos, Amosite] results in increased activity of PARP1 protein; CAT protein inhibits the reaction [Asbestos, Amosite results in increased activity of PARP1 protein]; Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of PARP1 protein] CTD PMID:11217149 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcdh15 protocadherin related 15 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDH15 promoter CTD PMID:29626692 NCBI chr20:13,997,094...15,496,446
Ensembl chr20:13,963,565...15,494,719 		JBrowse link
G Pcdh8 protocadherin 8 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDH8 promoter CTD PMID:29626692 NCBI chr15:55,198,470...55,203,039
Ensembl chr15:55,198,459...55,205,872 		JBrowse link
G Pcdha1 protocadherin alpha 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHA1 promoter CTD PMID:29626692 Ensembl chr18:28,581,225...28,846,211 JBrowse link
G Pcdha10 protocadherin alpha 10 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHA10 promoter CTD PMID:29626692 Ensembl chr18:28,581,225...28,846,211 JBrowse link
G Pcdha11 protocadherin alpha 11 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHA11 promoter CTD PMID:29626692 Ensembl chr18:28,581,225...28,846,211 JBrowse link
G Pcdha13 protocadherin alpha 13 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHA13 promoter CTD PMID:29626692 Ensembl chr18:28,581,225...28,846,211 JBrowse link
G Pcdha3 protocadherin alpha 3 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHA3 promoter CTD PMID:29626692 Ensembl chr18:28,581,225...28,846,211 JBrowse link
G Pcdha5 protocadherin alpha 5 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHA5 promoter CTD PMID:29626692 Ensembl chr18:28,581,225...28,846,211 JBrowse link
G Pcdha6 protocadherin alpha 6 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHA6 promoter CTD PMID:29626692 Ensembl chr18:28,581,225...28,846,211 JBrowse link
G Pcdha7 protocadherin alpha 7 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHA7 promoter CTD PMID:29626692 Ensembl chr18:28,581,225...28,846,211 JBrowse link
G Pcdha8 protocadherin alpha 8 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHA8 promoter CTD PMID:29626692 Ensembl chr18:28,581,225...28,846,211 JBrowse link
G Pcdhac1 protocadherin alpha subfamily C, 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHAC1 promoter CTD PMID:29626692 NCBI chr18:28,740,353...28,750,216
Ensembl chr18:28,581,225...28,846,211 		JBrowse link
G Pcdhac2 protocadherin alpha subfamily C, 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHAC2 promoter CTD PMID:29626692 Ensembl chr18:28,581,225...28,846,211 JBrowse link
G Pcdhga10 protocadherin gamma subfamily A, 10 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHGA10 promoter CTD PMID:29626692 NCBI chr18:29,574,693...29,667,865
Ensembl chr18:29,493,954...29,667,868 		JBrowse link
G Pcdhga11 protocadherin gamma subfamily A, 11 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHGA11 promoter CTD PMID:29626692 NCBI chr18:29,583,373...29,667,865
Ensembl chr18:29,493,954...29,667,868 		JBrowse link
G Pcdhga12 protocadherin gamma subfamily A, 12 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHGA12 promoter CTD PMID:29626692 NCBI chr18:29,592,664...29,667,865
Ensembl chr18:29,493,954...29,667,868 		JBrowse link
G Pcdhga3 protocadherin gamma subfamily A, 3 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHGA3 promoter CTD PMID:29626692 NCBI chr18:29,499,148...29,667,865
Ensembl chr18:29,493,954...29,667,868 		JBrowse link
G Pcdhga4 protocadherin gamma subfamily A, 4 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHGA4 promoter CTD PMID:29626692 NCBI chr18:29,508,152...29,543,103 JBrowse link
G Pcdhga5 protocadherin gamma subfamily A, 5 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHGA5 promoter CTD PMID:29626692 NCBI chr18:29,519,705...29,667,865
Ensembl chr18:29,493,954...29,667,868 		JBrowse link
G Pcdhga7 protocadherin gamma subfamily A, 7 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHGA7 promoter CTD PMID:29626692 NCBI chr18:29,543,018...29,667,865
Ensembl chr18:29,493,954...29,667,868 		JBrowse link
G Pcdhga8 protocadherin gamma subfamily A, 8 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHGA8 promoter CTD PMID:29626692 NCBI chr18:29,553,882...29,667,865
Ensembl chr18:29,493,954...29,667,868 		JBrowse link
G Pcdhgb7 protocadherin gamma subfamily B, 7 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PCDHGB7 promoter CTD PMID:29626692 NCBI chr18:29,579,129...29,667,868
Ensembl chr18:29,493,954...29,667,868 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions
increases expression
decreases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]; Deferoxamine inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]; Iron promotes the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]; tetramethylthiourea inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]
Asbestos, Amosite results in decreased expression of PDGFA mRNA		 CTD PMID:11306436 PMID:12475806 PMID:21797767 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma increases expression ISO Asbestos, Amosite results in increased expression of PIK3CG mRNA CTD PMID:29112861 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Plekhg5 pleckstrin homology and RhoGEF domain containing G5 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PLEKHG5 promoter CTD PMID:29626692 NCBI chr 5:162,577,999...162,621,518
Ensembl chr 5:162,578,071...162,621,513 		JBrowse link
G Potefam1 POTE ankyrin domain family member 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of ANKRD30A promoter CTD PMID:29626692 NCBI chr 3:97,641,258...97,826,965
Ensembl chr 3:97,641,261...97,826,949 		JBrowse link
G Pou2f2 POU class 2 homeobox 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of POU2F2 promoter CTD PMID:29626692 NCBI chr 1:80,682,330...80,769,756
Ensembl chr 1:80,685,741...80,724,261 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PRKAA2 promoter CTD PMID:29626692 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Prrx2 paired related homeobox 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of PRRX2 promoter CTD PMID:29626692 NCBI chr 3:14,132,574...14,168,533
Ensembl chr 3:14,094,004...14,168,535 		JBrowse link
G Prss3 serine protease 3 increases methylation ISO Asbestos, Amosite results in increased methylation of PRSS3 gene CTD PMID:32062310 NCBI chr 4:70,203,088...70,206,562
Ensembl chr 4:70,203,088...70,206,562 		JBrowse link
G Ptk2 protein tyrosine kinase 2 increases activity ISO Asbestos, Amosite results in increased activity of PTK2 protein CTD PMID:29112861 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 decreases methylation ISO Asbestos, Amosite results in decreased methylation of RIPK3 promoter CTD PMID:29626692 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Rnf146 ring finger protein 146 increases methylation ISO Asbestos, Amosite results in increased methylation of RNF146 promoter CTD PMID:29626692 NCBI chr 1:28,458,864...28,475,758
Ensembl chr 1:28,458,887...28,475,923 		JBrowse link
G Rps27a ribosomal protein S27a decreases expression ISO Asbestos, Amosite results in decreased expression of RPS27A mRNA CTD PMID:23917077 NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011 		JBrowse link
G Rps6 ribosomal protein S6 increases expression EXP Asbestos, Amosite results in increased expression of RPS6 protein modified form CTD PMID:27083413 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Satb2 SATB homeobox 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of SATB2 promoter CTD PMID:29626692 NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707 		JBrowse link
G Sbds Sbds, ribosome maturation factor increases methylation ISO Asbestos, Amosite results in increased methylation of SBDS promoter CTD PMID:29626692 NCBI chr12:26,420,410...26,429,650
Ensembl chr12:26,420,414...26,429,649 		JBrowse link
G Serac1 serine active site containing 1 increases methylation ISO Asbestos, Amosite results in increased methylation of SERAC1 promoter CTD PMID:29626692 NCBI chr 1:46,620,741...46,656,801
Ensembl chr 1:46,620,498...46,656,727 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of SGK1 promoter CTD PMID:29626692 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Slco3a1 solute carrier organic anion transporter family, member 3a1 decreases expression ISO Asbestos, Amosite results in decreased expression of SLCO3A1 mRNA CTD PMID:23917077 NCBI chr 1:128,106,232...128,388,043
Ensembl chr 1:128,106,228...128,387,925 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Asbestos, Amosite co-treated with TNF protein] results in increased activity of SOD2 protein; [Asbestos, Amosite co-treated with TNF protein] results in increased expression of SOD2 mRNA CTD PMID:8817062 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases activity ISO Asbestos, Amosite results in increased activity of SRC protein CTD PMID:29112861 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression
increases activity		 EXP
ISO		 Asbestos, Amosite results in increased expression of STAT3 protein modified form
Asbestos, Amosite results in increased activity of STAT3 protein
Asbestos, Amosite results in increased expression of STAT3 mRNA		 CTD PMID:27083413 PMID:29112861 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tbr1 T-box brain transcription factor 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of TBR1 promoter CTD PMID:29626692 NCBI chr 3:46,350,237...46,368,397
Ensembl chr 3:46,351,213...46,361,041 		JBrowse link
G Tbx4 T-box transcription factor 4 decreases methylation ISO Asbestos, Amosite results in decreased methylation of TBX4 promoter CTD PMID:29626692 NCBI chr10:70,730,686...70,760,829
Ensembl chr10:70,731,163...70,760,825 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
decreases expression		 EXP Asbestos, Amosite results in increased expression of TGFB1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Amosite results in increased expression of TGFB1 mRNA]; Deferoxamine inhibits the reaction [Asbestos, Amosite results in increased expression of TGFB1 mRNA]; Iron promotes the reaction [Asbestos, Amosite results in increased expression of TGFB1 mRNA]; tetramethylthiourea inhibits the reaction [Asbestos, Amosite results in increased expression of TGFB1 mRNA]
Asbestos, Amosite results in decreased expression of TGFB1 mRNA		 CTD PMID:11306436 PMID:12475806 PMID:21797767 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tiam2 TIAM Rac1 associated GEF 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of TIAM2 promoter CTD PMID:29626692 NCBI chr 1:43,918,179...44,119,499
Ensembl chr 1:43,918,174...44,119,493 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression ISO Asbestos, Amosite results in decreased expression of TIMP3 mRNA CTD PMID:23917077 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Tlx2 T-cell leukemia homeobox 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of TLX2 promoter CTD PMID:29626692 NCBI chr 4:115,573,736...115,576,097
Ensembl chr 4:115,573,799...115,575,642 		JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion
multiple interactions		 EXP
ISO		 Asbestos, Amosite results in increased expression of TNF protein
Asbestos, Amosite results in increased secretion of TNF protein
Asbestos, Amosite results in increased expression of TNF mRNA
[Asbestos, Amosite co-treated with TNF protein] results in increased activity of SOD2 protein; [Asbestos, Amosite co-treated with TNF protein] results in increased expression of SOD2 mRNA; [Asbestos, Amosite co-treated with TNF protein] results in increased metabolism of Adenosine Triphosphate; [Asbestos, Amosite co-treated with TNF protein] results in increased susceptibility to Vitamin K 3; Vitamin K 3 promotes the reaction [[Asbestos, Amosite co-treated with TNF protein] results in increased metabolism of Adenosine Triphosphate]		 CTD PMID:8473757 PMID:8817062 PMID:27083413 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 affects localization
increases expression
multiple interactions
increases response to substance		 ISO
EXP		 Asbestos, Amosite affects the localization of TP53 protein
Asbestos, Amosite results in increased expression of TP53 mRNA; Asbestos, Amosite results in increased expression of TP53 protein
Deferoxamine inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]; Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]; Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein]; Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]
TP53 protein results in increased susceptibility to Asbestos, Amosite
Asbestos, Amosite results in increased susceptibility to [NF2 protein mutant form co-treated with CDKN2A protein mutant form co-treated with TRP53 protein mutant form]		 CTD PMID:16357363 PMID:37441092 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ttyh1 tweety family member 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of TTYH1 promoter CTD PMID:29626692 NCBI chr 1:70,053,312...70,071,872
Ensembl chr 1:70,053,324...70,071,845 		JBrowse link
G Ttyh2 tweety family member 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of TTYH2 promoter CTD PMID:29626692 NCBI chr10:99,709,063...99,753,449
Ensembl chr10:99,709,007...99,753,444 		JBrowse link
G Ttyh3 tweety family member 3 decreases methylation ISO Asbestos, Amosite results in decreased methylation of TTYH3 promoter CTD PMID:29626692 NCBI chr12:13,996,831...14,025,457
Ensembl chr12:13,997,045...14,025,459 		JBrowse link
G Ubp1 upstream binding protein 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of UBP1 promoter CTD PMID:29626692 NCBI chr 8:113,869,771...113,915,625
Ensembl chr 8:113,869,979...113,915,625 		JBrowse link
G Ushbp1 USH1 protein network component harmonin binding protein 1 decreases expression ISO Asbestos, Amosite results in decreased expression of USHBP1 mRNA CTD PMID:23917077 NCBI chr16:18,057,321...18,067,933
Ensembl chr16:18,057,326...18,067,877 		JBrowse link
G Usp37 ubiquitin specific peptidase 37 increases methylation ISO Asbestos, Amosite results in increased methylation of USP37 promoter CTD PMID:29626692 NCBI chr 9:76,018,863...76,118,732
Ensembl chr 9:76,018,991...76,084,044 		JBrowse link
G Vax1 ventral anterior homeobox 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of VAX1 promoter CTD PMID:29626692 NCBI chr 1:258,324,571...258,342,396
Ensembl chr 1:258,326,276...258,330,192 		JBrowse link
G Vax2 ventral anterior homeobox 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of VAX2 promoter CTD PMID:29626692 NCBI chr 4:116,195,528...116,219,597
Ensembl chr 4:116,195,528...116,219,594 		JBrowse link
G Ventx VENT homeobox decreases methylation ISO Asbestos, Amosite results in decreased methylation of VENTX promoter CTD PMID:29626692 NCBI chr  X:86,483,893...86,484,900
Ensembl chr  X:86,483,893...86,484,954 		JBrowse link
G Vrk3 VRK serine/threonine kinase 3 decreases methylation ISO Asbestos, Amosite results in decreased methylation of VRK3 promoter CTD PMID:29626692 NCBI chr 1:95,243,344...95,270,780
Ensembl chr 1:95,243,364...95,270,780 		JBrowse link
G Vsx1 visual system homeobox 1 decreases methylation ISO Asbestos, Amosite results in decreased methylation of VSX1 promoter CTD PMID:29626692 NCBI chr 3:139,514,270...139,521,869
Ensembl chr 3:139,514,270...139,521,869 		JBrowse link
G Vsx2 visual system homeobox 2 decreases methylation ISO Asbestos, Amosite results in decreased methylation of VSX2 promoter CTD PMID:29626692 NCBI chr 6:104,214,842...104,240,264
Ensembl chr 6:104,217,230...104,240,018 		JBrowse link
G Wnk4 WNK lysine deficient protein kinase 4 decreases methylation ISO Asbestos, Amosite results in decreased methylation of WNK4 promoter CTD PMID:29626692 NCBI chr10:86,202,552...86,219,655
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G Wnt10a Wnt family member 10A decreases methylation ISO Asbestos, Amosite results in decreased methylation of WNT10A promoter CTD PMID:29626692 NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400 		JBrowse link
G Wnt11 Wnt family member 11 decreases methylation ISO Asbestos, Amosite results in decreased methylation of WNT11 promoter CTD PMID:29626692 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294 		JBrowse link
G Wnt5b Wnt family member 5B decreases methylation ISO Asbestos, Amosite results in decreased methylation of WNT5B promoter CTD PMID:29626692 NCBI chr 4:152,609,566...152,733,790
Ensembl chr 4:152,609,569...152,733,407 		JBrowse link
G Wnt7a Wnt family member 7A decreases methylation ISO Asbestos, Amosite results in decreased methylation of WNT7A promoter CTD PMID:29626692 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
increases expression		 ISO Asbestos, Amosite results in increased expression of and affects the splicing of XBP1 mRNA; BCL2L1 protein inhibits the reaction [Asbestos, Amosite results in increased expression of XBP1 protein alternative form] CTD PMID:23885834 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Zcwpw2 zinc finger CW-type and PWWP domain containing 2 decreases expression ISO Asbestos, Amosite results in decreased expression of ZCWPW2 mRNA CTD PMID:23917077 NCBI chr 8:117,628,838...117,773,096
Ensembl chr 8:117,681,238...117,773,739 		JBrowse link
G Zzz3 zinc finger, ZZ-type containing 3 increases methylation ISO Asbestos, Amosite results in increased methylation of ZZZ3 promoter CTD PMID:29626692 NCBI chr 2:241,330,366...241,397,308
Ensembl chr 2:241,331,022...241,397,307 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      chemical substance 14419
        mineral 4325
          silicate mineral 3764
            gruenerite 206
              amosite asbestos 206
paths to the root