CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: amosite asbestos
Accession: CHEBI:46678
browse the term
Synonyms: related_synonym: Amosit; Amosite; Brown asbestos; Formula=Fe7H2O24Si8; Grunerite asbestos; Mysorite; asbestiform gruenerite; brauner Asbest
xref: CAS:12172-73-5
xref_mesh: MESH:D017639
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Aatk
apoptosis-associated tyrosine kinase
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of AATK promoter
CTD
PMID:29626692
NCBI chr10:105,290,752...105,327,219
Ensembl chr10:105,291,585...105,327,112
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Abcg2
ATP binding cassette subfamily G member 2
increases methylation
ISO
Asbestos, Amosite results in increased methylation of ABCG2 promoter
CTD
PMID:29626692
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Abr
ABR activator of RhoGEF and GTPase
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of ABR promoter
CTD
PMID:29626692
NCBI chr10:61,262,516...61,461,331
Ensembl chr10:61,262,516...61,461,505
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Acod1
aconitate decarboxylase 1
decreases expression
ISO
Asbestos, Amosite results in decreased expression of ACOD1 mRNA
CTD
PMID:23917077
NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529
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Akt1
AKT serine/threonine kinase 1
increases activity
ISO
Asbestos, Amosite results in increased activity of AKT1 protein
CTD
PMID:29112861
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Ankrd11
ankyrin repeat domain containing 11
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of ANKRD11 promoter
CTD
PMID:29626692
NCBI chr19:50,940,284...51,098,962
Ensembl chr19:50,940,299...51,098,962
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Ankrd52
ankyrin repeat domain 52
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of ANKRD52 promoter
CTD
PMID:29626692
NCBI chr 7:806,829...820,481
Ensembl chr 7:806,767...820,481
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Ano1
anoctamin 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of ANO1 promoter
CTD
PMID:29626692
NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
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Arhgef17
Rho guanine nucleotide exchange factor 17
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of ARHGEF17 promoter
CTD
PMID:29626692
NCBI chr 1:155,230,607...155,290,163
Ensembl chr 1:155,233,168...155,290,498
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Arhgef18
Rho/Rac guanine nucleotide exchange factor 18
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of ARHGEF18 promoter
CTD
PMID:29626692
NCBI chr12:1,395,035...1,503,082
Ensembl chr12:1,395,088...1,503,081
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Arhgef4
Rho guanine nucleotide exchange factor 4
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of ARHGEF4 promoter
CTD
PMID:29626692
NCBI chr 9:36,861,800...37,005,079
Ensembl chr 9:36,861,835...37,005,075
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Arrdc3
arrestin domain containing 3
increases methylation
ISO
Asbestos, Amosite results in increased methylation of ARRDC3 promoter
CTD
PMID:29626692
NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978
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Atg16l2
autophagy related 16-like 2
increases methylation
ISO
Asbestos, Amosite results in increased methylation of ATG16L2 promoter
CTD
PMID:29626692
NCBI chr 1:155,687,386...155,703,419
Ensembl chr 1:155,684,564...155,703,420
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Atp12a
ATPase H+/K+ transporting non-gastric alpha2 subunit
decreases expression
ISO
Asbestos, Amosite results in decreased expression of ATP12A mRNA
CTD
PMID:23917077
NCBI chr15:30,443,571...30,468,229
Ensembl chr15:30,443,571...30,468,229
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Atp2c2
ATPase secretory pathway Ca2+ transporting 2
increases expression
ISO
Asbestos, Amosite results in increased expression of ATP2C2 mRNA
CTD
PMID:23917077
NCBI chr19:47,754,120...47,811,369
Ensembl chr19:47,754,120...47,811,368
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Aurkc
aurora kinase C
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of AURKC promoter
CTD
PMID:29626692
NCBI chr 1:66,843,653...66,849,775
Ensembl chr 1:66,843,653...66,864,386
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Barx1
BARX homeobox 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of BARX1 promoter
CTD
PMID:29626692
NCBI chr17:15,990,412...15,993,887
Ensembl chr17:15,990,412...15,993,887
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions affects localization
ISO
pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of BAX protein]
CTD
PMID:16357363
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2l1
Bcl2-like 1
multiple interactions
ISO
BCL2L1 protein inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]; BCL2L1 protein inhibits the reaction [Asbestos, Amosite results in increased expression of XBP1 protein alternative form]
CTD
PMID:23885834
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Best1
bestrophin 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of BEST1 promoter
CTD
PMID:29626692
NCBI chr 1:206,629,340...206,646,085
Ensembl chr 1:206,629,500...206,646,063
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Best4
bestrophin 4
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of BEST4 promoter
CTD
PMID:29626692
NCBI chr 5:130,622,194...130,629,045
Ensembl chr 5:130,623,438...130,627,099
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Bhlha9
basic helix-loop-helix family, member a9
decreases expression
ISO
Asbestos, Amosite results in decreased expression of BHLHA9 mRNA
CTD
PMID:23917077
NCBI chr10:61,513,609...61,514,730
Ensembl chr10:61,513,609...61,514,301
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Bsx
brain specific homeobox
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of BSX promoter
CTD
PMID:29626692
NCBI chr 8:41,254,105...41,257,861
Ensembl chr 8:41,254,105...41,257,861
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Bub1
BUB1 mitotic checkpoint serine/threonine kinase
increases expression
ISO
Asbestos, Amosite results in increased expression of BUB1 mRNA
CTD
PMID:23917077
NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
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Camk4
calcium/calmodulin-dependent protein kinase IV
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of CAMK4 promoter
CTD
PMID:29626692
NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
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Casp3
caspase 3
increases activity multiple interactions
ISO
Asbestos, Amosite results in increased activity of CASP3 protein Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein]; Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein]
CTD
PMID:11329530
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
multiple interactions increases activity
EXP ISO
pifithrin inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein] 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]; Deferoxamine inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]; Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]; Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]
CTD
PMID:12540492 PMID:14766669 PMID:16357363
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions
ISO
CAT protein inhibits the reaction [Asbestos, Amosite results in increased activity of PARP1 protein]
CTD
PMID:11217149
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cdh16
cadherin 16
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of CDH16 promoter
CTD
PMID:29626692
NCBI chr19:360,824...371,008
Ensembl chr19:360,824...371,007
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Cdh22
cadherin 22
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of CDH22 promoter
CTD
PMID:29626692
NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:153,845,787...153,970,588
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Cdh3
cadherin 3
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of CDH3 promoter
CTD
PMID:29626692
NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
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Cdh6
cadherin 6
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of CDH6 promoter
CTD
PMID:29626692
NCBI chr 2:62,079,139...62,225,298
Ensembl chr 2:62,079,137...62,225,228
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Cdh7
cadherin 7
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of CDH7 promoter
CTD
PMID:29626692
NCBI chr13:26,672,058...26,821,571
Ensembl chr13:26,672,484...26,819,846
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Cdk18
cyclin-dependent kinase 18
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of CDK18 promoter
CTD
PMID:29626692
NCBI chr13:43,555,597...43,582,210
Ensembl chr13:43,556,748...43,588,525
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of CDKN1A gene
CTD
PMID:30990028
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
increases methylation multiple interactions decreases expression
ISO
Asbestos, Amosite results in increased methylation of CDKN2A exon Asbestos, Amosite results in increased susceptibility to [NF2 protein mutant form co-treated with CDKN2A protein mutant form co-treated with TRP53 protein mutant form] Asbestos, Amosite results in decreased expression of CDKN2A mRNA; Asbestos, Amosite results in decreased expression of CDKN2A mRNA alternative form; Asbestos, Amosite results in decreased expression of CDKN2A protein; Asbestos, Amosite results in decreased expression of CDKN2A protein alternative form
CTD
PMID:29112861 PMID:37441092
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Cdx2
caudal type homeo box 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of CDX2 promoter
CTD
PMID:29626692
NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142
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Cmss1
cms1 ribosomal small subunit homolog
decreases expression
ISO
Asbestos, Amosite results in decreased expression of CMSS1 mRNA
CTD
PMID:23917077
NCBI chr11:42,934,390...43,232,624
Ensembl chr11:42,934,440...43,232,624
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Cnot9
CCR4-NOT transcription complex subunit 9
increases methylation
ISO
Asbestos, Amosite results in increased methylation of CNOT9 promoter
CTD
PMID:29626692
NCBI chr 9:76,084,269...76,109,111
Ensembl chr 9:76,084,334...76,109,100
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Col1a1
collagen type I alpha 1 chain
multiple interactions increases expression
EXP
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Asbestos, Amosite results in increased expression of COL1A1 mRNA]; Deferoxamine inhibits the reaction [Asbestos, Amosite results in increased expression of COL1A1 mRNA]; Iron promotes the reaction [Asbestos, Amosite results in increased expression of COL1A1 mRNA]; tetramethylthiourea inhibits the reaction [Asbestos, Amosite results in increased expression of COL1A1 mRNA]
CTD
PMID:11306436
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Cxcl1
C-X-C motif chemokine ligand 1
increases expression
EXP
Asbestos, Amosite results in increased expression of CXCL1 protein
CTD
PMID:27083413
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxxc1
CXXC finger protein 1
increases methylation
ISO
Asbestos, Amosite results in increased methylation of CXXC1 promoter
CTD
PMID:29626692
NCBI chr18:67,813,185...67,818,556
Ensembl chr18:67,813,206...67,818,551
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Dclk1
doublecortin-like kinase 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of DCLK1 promoter
CTD
PMID:29626692
NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Asbestos, Amosite results in increased expression of DDIT3 mRNA
CTD
PMID:23885834
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Dennd3
DENN domain containing 3
increases methylation
ISO
Asbestos, Amosite results in increased methylation of DENND3 promoter
CTD
PMID:29626692
NCBI chr 7:105,415,870...105,473,583
Ensembl chr 7:105,415,677...105,473,592
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Dlx4
distal-less homeobox 4
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of DLX4 promoter
CTD
PMID:29626692
NCBI chr10:80,085,037...80,090,434
Ensembl chr10:80,085,465...80,090,456
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Dmpk
DM1 protein kinase
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of DMPK promoter
CTD
PMID:29626692
NCBI chr 1:78,730,255...78,740,585
Ensembl chr 1:78,730,275...78,740,593
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Egfr
epidermal growth factor receptor
increases expression decreases phosphorylation
EXP ISO
Asbestos, Amosite results in increased expression of EGFR mRNA Asbestos, Amosite results in decreased phosphorylation of EGFR protein
CTD
PMID:15626777 PMID:22251266
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Emx1
empty spiracles homeobox 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of EMX1 promoter
CTD
PMID:29626692
NCBI chr 4:117,725,148...117,741,616
Ensembl chr 4:117,725,155...117,741,613
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En2
engrailed homeobox 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of EN2 promoter
CTD
PMID:29626692
NCBI chr 4:7,221,096...7,226,943
Ensembl chr 4:7,221,096...7,226,943
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Ern1
endoplasmic reticulum to nucleus signaling 1
increases expression multiple interactions
ISO EXP
Asbestos, Amosite results in increased expression of ERN1 mRNA; Asbestos, Amosite results in increased expression of ERN1 protein 4-phenylbutyric acid inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]; BCL2L1 protein inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]; EUK-134 inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]
CTD
PMID:23885834
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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Ern2
endoplasmic reticulum to nucleus signaling 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of ERN2 promoter
CTD
PMID:29626692
NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289
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Esyt3
extended synaptotagmin 3
increases expression
ISO
Asbestos, Amosite results in increased expression of ESYT3 mRNA
CTD
PMID:23917077
NCBI chr 8:99,870,418...99,917,298
Ensembl chr 8:99,871,149...99,917,232
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Evx1
even-skipped homeobox 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of EVX1 promoter
CTD
PMID:29626692
NCBI chr 4:81,416,590...81,420,967
Ensembl chr 4:81,416,590...81,420,967
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Evx2
even-skipped homeobox 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of EVX2 promoter
CTD
PMID:29626692
NCBI chr 3:59,558,197...59,562,267
Ensembl chr 3:59,558,197...59,561,872
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Fam72a
family with sequence similarity 72, member A
increases methylation
ISO
Asbestos, Amosite results in increased methylation of FAM72A promoter
CTD
PMID:29626692
NCBI chr13:42,967,701...42,979,083
Ensembl chr13:42,967,578...42,984,208
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Farp1
FERM, ARH/RhoGEF and pleckstrin domain protein 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of FARP1 promoter
CTD
PMID:29626692
NCBI chr15:98,124,304...98,363,299
Ensembl chr15:98,182,329...98,363,299
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Fat3
FAT atypical cadherin 3
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of FAT3 promoter
CTD
PMID:29626692
NCBI chr 8:12,691,470...13,274,336
Ensembl chr 8:12,694,019...13,273,135
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Fcsk
fucose kinase
increases methylation
ISO
Asbestos, Amosite results in increased methylation of FCSK promoter
CTD
PMID:29626692
NCBI chr19:38,849,130...38,874,497
Ensembl chr19:38,854,762...38,874,418
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Foxd2
forkhead box D2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of FOXD2 promoter
CTD
PMID:29626692
NCBI chr 5:128,427,986...128,430,709
Ensembl chr 5:128,429,020...128,430,504
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Foxe3
forkhead box E3
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of FOXE3 promoter
CTD
PMID:29626692
NCBI chr 5:128,444,912...128,446,494
Ensembl chr 5:128,445,594...128,446,454
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Foxg1
forkhead box G1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of FOXG1 promoter
CTD
PMID:29626692
NCBI chr 6:66,674,797...66,677,611
Ensembl chr 6:66,666,587...66,678,607
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Foxi1
forkhead box I1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of FOXI1 promoter
CTD
PMID:29626692
NCBI chr10:18,806,292...18,810,231
Ensembl chr10:18,806,308...18,810,231
G
Foxi2
forkhead box I2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of FOXI2 promoter
CTD
PMID:29626692
NCBI chr 1:190,222,857...190,226,657
Ensembl chr 1:190,222,703...190,226,433
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Foxk1
forkhead box K1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of FOXK1 promoter
CTD
PMID:29626692
NCBI chr12:12,110,119...12,175,089
Ensembl chr12:12,115,950...12,175,089
G
Foxl1
forkhead box L1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of FOXL1 promoter
CTD
PMID:29626692
NCBI chr19:49,197,269...49,200,682
Ensembl chr19:49,197,400...49,198,425
G
Foxn3
forkhead box N3
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of FOXN3 promoter
CTD
PMID:29626692
NCBI chr 6:118,462,018...118,842,442
Ensembl chr 6:118,466,025...118,842,401
G
Fxyd1
FXYD domain-containing ion transport regulator 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of FXYD1 promoter
CTD
PMID:29626692
NCBI chr 1:86,287,163...86,291,478
Ensembl chr 1:86,287,165...86,291,278
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Fxyd6
FXYD domain-containing ion transport regulator 6
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of FXYD6 promoter
CTD
PMID:29626692
NCBI chr 8:45,679,054...45,705,958
Ensembl chr 8:45,678,885...45,705,958
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G6pd
glucose-6-phosphate dehydrogenase
decreases activity multiple interactions
ISO
Asbestos, Amosite results in decreased activity of G6PD protein Glutathione inhibits the reaction [Asbestos, Amosite results in decreased activity of G6PD protein]
CTD
PMID:14613721 PMID:18370412
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Gak
cyclin G associated kinase
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of GAK promoter
CTD
PMID:29626692
NCBI chr14:1,089,853...1,164,098
Ensembl chr14:1,089,866...1,216,398
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Gsc2
goosecoid homeobox 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of GSC2 promoter
CTD
PMID:29626692
NCBI chr11:83,070,784...83,075,874
Ensembl chr11:83,072,138...83,074,126
G
Gtf2ird1
GTF2I repeat domain containing 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of GTF2IRD1 promoter
CTD
PMID:29626692
NCBI chr12:22,254,113...22,361,052
Ensembl chr12:22,254,221...22,361,040
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Hck
HCK proto-oncogene, Src family tyrosine kinase
increases activity
ISO
Asbestos, Amosite results in increased activity of HCK protein
CTD
PMID:29112861
NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
G
Hlx
H2.0-like homeobox
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HLX promoter
CTD
PMID:29626692
NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750
G
Hoxa10
homeobox A10
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXA10 promoter
CTD
PMID:29626692
NCBI chr 4:81,331,591...81,340,878
Ensembl chr 4:81,331,591...81,340,919
G
Hoxa11
homeobox A11
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXA11 promoter
CTD
PMID:29626692
NCBI chr 4:81,342,527...81,346,189
Ensembl chr 4:81,342,528...81,346,232
G
Hoxa13
homeo box A13
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXA13 promoter
CTD
PMID:29626692
NCBI chr 4:81,358,956...81,361,091
Ensembl chr 4:81,358,956...81,361,091
G
Hoxa3
homeobox A3
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXA3 promoter
CTD
PMID:29626692
NCBI chr 4:81,269,243...81,313,218
Ensembl chr 4:81,269,243...81,313,218
G
Hoxa4
homeo box A4
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXA4 promoter
CTD
PMID:29626692
NCBI chr 4:81,289,677...81,291,685
Ensembl chr 4:81,289,682...81,291,685
G
Hoxa6
homeobox A6
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXA6 promoter
CTD
PMID:29626692
NCBI chr 4:81,304,918...81,313,184
Ensembl chr 4:81,306,407...81,308,850
G
Hoxa9
homeobox A9
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXA9 promoter
CTD
PMID:29626692
NCBI chr 4:81,323,235...81,329,344
Ensembl chr 4:81,323,382...81,326,358
G
Hoxb1
homeo box B1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXB1 promoter
CTD
PMID:29626692
NCBI chr10:81,331,507...81,332,928
Ensembl chr10:81,331,507...81,332,836
G
Hoxb3
homeo box B3
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXB3 promoter
CTD
PMID:29626692
NCBI chr10:81,258,739...81,314,134
Ensembl chr10:81,299,357...81,313,107
G
Hoxb5
homeo box B5
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXB5 promoter
CTD
PMID:29626692
NCBI chr10:81,269,372...81,271,580
Ensembl chr10:81,269,372...81,271,580
G
Hoxb6
homeo box B6
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXB6 promoter
CTD
PMID:29626692
NCBI chr10:81,258,726...81,267,458
Ensembl chr10:81,265,056...81,267,449
G
Hoxb7
homeo box B7
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXB7 promoter
CTD
PMID:29626692
NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034
G
Hoxb8
homeo box B8
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXB8 promoter
CTD
PMID:29626692
NCBI chr10:81,248,313...81,251,261
Ensembl chr10:81,248,887...81,250,638
G
Hoxb9
homeo box B9
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXB9 promoter
CTD
PMID:29626692
NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
G
Hoxc11
homeobox C11
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXC11 promoter
CTD
PMID:29626692
NCBI chr 7:134,091,224...134,094,738
Ensembl chr 7:134,091,552...134,094,738
G
Hoxc4
homeo box C4
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXC4 promoter
CTD
PMID:29626692
NCBI chr 7:134,135,279...134,173,133
Ensembl chr 7:134,170,591...134,173,133
G
Hoxc5
homeo box C5
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXC5 promoter
CTD
PMID:29626692
NCBI chr 7:134,150,988...134,154,410
Ensembl chr 7:134,150,988...134,154,410
G
Hoxd11
homeobox D11
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXD11 promoter
CTD
PMID:29626692
NCBI chr 3:59,584,840...59,587,257
Ensembl chr 3:59,585,039...59,586,783
G
Hoxd12
homeo box D12
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXD12 promoter
CTD
PMID:29626692
NCBI chr 3:59,577,677...59,578,798
Ensembl chr 3:59,577,677...59,578,798
G
Hoxd4
homeo box D4
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXD4 promoter
CTD
PMID:29626692
NCBI chr 3:59,614,464...59,634,042
Ensembl chr 3:59,614,464...59,631,528
G
Hoxd8
homeobox D8
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HOXD8 promoter
CTD
PMID:29626692
NCBI chr 3:59,607,793...59,610,359
Ensembl chr 3:59,607,996...59,610,361
G
Hpcal1
hippocalcin-like 1
increases methylation
ISO
Asbestos, Amosite results in increased methylation of HPCAL1 gene
CTD
PMID:32062310
NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687
G
Hsf4
heat shock transcription factor 4
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of HSF4 promoter
CTD
PMID:29626692
NCBI chr19:33,147,755...33,153,479
Ensembl chr19:33,147,755...33,153,479
G
Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
Asbestos, Amosite results in increased expression of HSPA5 mRNA; Asbestos, Amosite results in increased expression of HSPA5 protein
CTD
PMID:23885834
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
G
Il1b
interleukin 1 beta
increases expression increases secretion
EXP ISO
Asbestos, Amosite results in increased expression of IL1B protein Asbestos, Amosite results in increased expression of IL1B mRNA Asbestos, Amosite results in increased secretion of IL1B protein
CTD
PMID:8473757 PMID:27083413
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
increases expression
ISO
Asbestos, Amosite results in increased expression of IL6 mRNA
CTD
PMID:29112861
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Iqub
IQ motif and ubiquitin domain containing
increases methylation
ISO
Asbestos, Amosite results in increased methylation of IQUB promoter
CTD
PMID:29626692
NCBI chr 4:52,931,768...52,993,795
Ensembl chr 4:52,931,767...52,993,834
G
Irx6
iroquois homeobox 6
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of IRX6 promoter
CTD
PMID:29626692
NCBI chr19:14,330,440...14,336,403
Ensembl chr19:14,330,440...14,336,403
G
Isl2
ISL LIM homeobox 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of ISL2 promoter
CTD
PMID:29626692
NCBI chr 8:55,923,805...55,928,790
Ensembl chr 8:55,923,805...55,928,790
G
Kcnj6
potassium inwardly-rectifying channel, subfamily J, member 6
increases expression
ISO
Asbestos, Amosite results in increased expression of KCNJ6 mRNA
CTD
PMID:23917077
NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758
G
Klf3
KLF transcription factor 3
increases methylation
ISO
Asbestos, Amosite results in increased methylation of KLF3 gene
CTD
PMID:32062310
NCBI chr14:43,474,767...43,505,801
Ensembl chr14:43,474,767...43,497,209
G
Klk1c10
kallikrein 1-related peptidase C10
increases methylation
ISO
Asbestos, Amosite results in increased methylation of KLK3 gene
CTD
PMID:32062310
NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
G
Lbx2
ladybird homeobox 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of LBX2 promoter
CTD
PMID:29626692
NCBI chr 4:115,591,974...115,593,859
Ensembl chr 4:115,591,974...115,594,132
G
Lck
LCK proto-oncogene, Src family tyrosine kinase
increases activity
ISO
Asbestos, Amosite results in increased activity of LCK protein
CTD
PMID:29112861
NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
G
Lhx2
LIM homeobox 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of LHX2 promoter
CTD
PMID:29626692
NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908
G
Lhx3
LIM homeobox 3
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of LHX3 promoter
CTD
PMID:29626692
NCBI chr 3:9,026,432...9,035,122
Ensembl chr 3:9,027,425...9,034,480
G
Lhx6
LIM homeobox 6
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of LHX6 promoter
CTD
PMID:29626692
NCBI chr 3:19,432,439...19,456,268
Ensembl chr 3:19,433,494...19,456,061
G
Lhx8
LIM homeobox 8
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of LHX8 promoter
CTD
PMID:29626692
NCBI chr 2:243,244,958...243,269,624
Ensembl chr 2:243,244,961...243,269,416
G
Lmx1a
LIM homeobox transcription factor 1 alpha
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of LMX1A promoter
CTD
PMID:29626692
NCBI chr13:79,834,614...79,978,253
Ensembl chr13:79,835,019...79,978,253
G
Lsm14b
LSM family member 14B
increases methylation
ISO
Asbestos, Amosite results in increased methylation of LSM14B promoter
CTD
PMID:29626692
NCBI chr 3:167,125,633...167,136,417
Ensembl chr 3:167,125,628...167,136,432
G
Ltk
leukocyte receptor tyrosine kinase
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of LTK promoter
CTD
PMID:29626692
NCBI chr 3:106,734,675...106,741,552
Ensembl chr 3:106,734,676...106,743,369
G
Map3k12
mitogen activated protein kinase kinase kinase 12
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of MAP3K12 promoter
CTD
PMID:29626692
NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789
G
Map3k6
mitogen-activated protein kinase kinase kinase 6
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of MAP3K6 promoter
CTD
PMID:29626692
NCBI chr 5:145,440,126...145,452,213
Ensembl chr 5:145,440,346...145,452,212
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation increases activity multiple interactions
EXP ISO
Asbestos, Amosite results in increased phosphorylation of MAPK1 protein Asbestos, Amosite results in increased activity of MAPK1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Amosite results in increased phosphorylation of MAPK1 protein]; Iron promotes the reaction [Asbestos, Amosite results in increased phosphorylation of MAPK1 protein]
CTD
PMID:11306436 PMID:29112861
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation increases activity multiple interactions
EXP ISO
Asbestos, Amosite results in increased phosphorylation of MAPK3 protein Asbestos, Amosite results in increased activity of MAPK3 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Amosite results in increased phosphorylation of MAPK3 protein]; Iron promotes the reaction [Asbestos, Amosite results in increased phosphorylation of MAPK3 protein]
CTD
PMID:11306436 PMID:29112861
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mcf2l
MCF.2 cell line derived transforming sequence-like
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of MCF2L promoter
CTD
PMID:29626692
NCBI chr16:76,507,133...76,652,893
Ensembl chr16:76,507,133...76,652,733
G
Mcm3ap
minichromosome maintenance complex component 3 associated protein
increases methylation
ISO
Asbestos, Amosite results in increased methylation of MCM3AP promoter
CTD
PMID:29626692
NCBI chr20:12,127,570...12,165,165
Ensembl chr20:12,127,570...12,165,165
G
Mknk2
MAPK interacting serine/threonine kinase 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of MKNK2 promoter
CTD
PMID:29626692
NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827
G
Mroh3
maestro heat-like repeat family member 3
increases expression
ISO
Asbestos, Amosite results in increased expression of MROH3 mRNA
CTD
PMID:23917077
NCBI chr13:47,630,004...47,665,461
Ensembl chr13:47,630,003...47,665,394
G
Mylk3
myosin light chain kinase 3
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of MYLK3 promoter
CTD
PMID:29626692
NCBI chr19:21,685,085...21,743,587
Ensembl chr19:21,691,929...21,742,954
G
Nf2
NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
multiple interactions
ISO
Asbestos, Amosite results in increased susceptibility to [NF2 protein mutant form co-treated with CDKN2A protein mutant form co-treated with TRP53 protein mutant form]
CTD
PMID:37441092
NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667
G
Nfix
nuclear factor I X
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of NFIX promoter
CTD
PMID:29626692
NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265
G
Nfkbid
NFKB inhibitor delta
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of NFKBID promoter
CTD
PMID:29626692
NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447
G
Ngef
neuronal guanine nucleotide exchange factor
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of NGEF promoter
CTD
PMID:29626692
NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914
G
Nkx6-2
NK6 homeobox 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of NKX6-2 promoter
CTD
PMID:29626692
NCBI chr 1:194,380,149...194,383,533
Ensembl chr 1:194,381,975...194,383,515
G
Noto
notochord homeobox
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of NOTO promoter
CTD
PMID:29626692
NCBI chr 4:117,961,163...117,965,402
Ensembl chr 4:117,961,163...117,965,402
G
Oas3
2'-5'-oligoadenylate synthetase 3
decreases expression
ISO
Asbestos, Amosite results in decreased expression of OAS3 mRNA
CTD
PMID:23917077
NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781
G
Onecut1
one cut homeobox 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of ONECUT1 promoter
CTD
PMID:29626692
NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277
G
Otp
orthopedia homeobox
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of OTP promoter
CTD
PMID:29626692
NCBI chr 2:26,108,158...26,116,359
Ensembl chr 2:26,108,163...26,116,359
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions increases activity
ISO
3-aminobenzamide inhibits the reaction [Asbestos, Amosite results in increased activity of PARP1 protein]; [Smoke analog co-treated with Asbestos, Amosite] results in increased activity of PARP1 protein; CAT protein inhibits the reaction [Asbestos, Amosite results in increased activity of PARP1 protein]; Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of PARP1 protein]
CTD
PMID:11217149
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Pcdh15
protocadherin related 15
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDH15 promoter
CTD
PMID:29626692
NCBI chr20:13,997,094...15,496,446
Ensembl chr20:13,963,565...15,494,719
G
Pcdh8
protocadherin 8
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDH8 promoter
CTD
PMID:29626692
NCBI chr15:55,198,470...55,203,039
Ensembl chr15:55,198,459...55,205,872
G
Pcdha1
protocadherin alpha 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHA1 promoter
CTD
PMID:29626692
Ensembl chr18:28,581,225...28,846,211
G
Pcdha10
protocadherin alpha 10
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHA10 promoter
CTD
PMID:29626692
Ensembl chr18:28,581,225...28,846,211
G
Pcdha11
protocadherin alpha 11
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHA11 promoter
CTD
PMID:29626692
Ensembl chr18:28,581,225...28,846,211
G
Pcdha13
protocadherin alpha 13
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHA13 promoter
CTD
PMID:29626692
Ensembl chr18:28,581,225...28,846,211
G
Pcdha3
protocadherin alpha 3
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHA3 promoter
CTD
PMID:29626692
Ensembl chr18:28,581,225...28,846,211
G
Pcdha5
protocadherin alpha 5
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHA5 promoter
CTD
PMID:29626692
Ensembl chr18:28,581,225...28,846,211
G
Pcdha6
protocadherin alpha 6
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHA6 promoter
CTD
PMID:29626692
Ensembl chr18:28,581,225...28,846,211
G
Pcdha7
protocadherin alpha 7
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHA7 promoter
CTD
PMID:29626692
Ensembl chr18:28,581,225...28,846,211
G
Pcdha8
protocadherin alpha 8
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHA8 promoter
CTD
PMID:29626692
Ensembl chr18:28,581,225...28,846,211
G
Pcdhac1
protocadherin alpha subfamily C, 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHAC1 promoter
CTD
PMID:29626692
NCBI chr18:28,740,353...28,750,216
Ensembl chr18:28,581,225...28,846,211
G
Pcdhac2
protocadherin alpha subfamily C, 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHAC2 promoter
CTD
PMID:29626692
Ensembl chr18:28,581,225...28,846,211
G
Pcdhga10
protocadherin gamma subfamily A, 10
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHGA10 promoter
CTD
PMID:29626692
NCBI chr18:29,574,693...29,667,865
Ensembl chr18:29,493,954...29,667,868
G
Pcdhga11
protocadherin gamma subfamily A, 11
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHGA11 promoter
CTD
PMID:29626692
NCBI chr18:29,583,373...29,667,865
Ensembl chr18:29,493,954...29,667,868
G
Pcdhga12
protocadherin gamma subfamily A, 12
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHGA12 promoter
CTD
PMID:29626692
NCBI chr18:29,592,664...29,667,865
Ensembl chr18:29,493,954...29,667,868
G
Pcdhga3
protocadherin gamma subfamily A, 3
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHGA3 promoter
CTD
PMID:29626692
NCBI chr18:29,499,148...29,667,865
Ensembl chr18:29,493,954...29,667,868
G
Pcdhga4
protocadherin gamma subfamily A, 4
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHGA4 promoter
CTD
PMID:29626692
NCBI chr18:29,508,152...29,543,103
G
Pcdhga5
protocadherin gamma subfamily A, 5
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHGA5 promoter
CTD
PMID:29626692
NCBI chr18:29,519,705...29,667,865
Ensembl chr18:29,493,954...29,667,868
G
Pcdhga7
protocadherin gamma subfamily A, 7
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHGA7 promoter
CTD
PMID:29626692
NCBI chr18:29,543,018...29,667,865
Ensembl chr18:29,493,954...29,667,868
G
Pcdhga8
protocadherin gamma subfamily A, 8
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHGA8 promoter
CTD
PMID:29626692
NCBI chr18:29,553,882...29,667,865
Ensembl chr18:29,493,954...29,667,868
G
Pcdhgb7
protocadherin gamma subfamily B, 7
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PCDHGB7 promoter
CTD
PMID:29626692
NCBI chr18:29,579,129...29,667,868
Ensembl chr18:29,493,954...29,667,868
G
Pdgfa
platelet derived growth factor subunit A
multiple interactions decreases expression increases expression
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]; Deferoxamine inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]; Iron promotes the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]; tetramethylthiourea inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA] Asbestos, Amosite results in decreased expression of PDGFA mRNA
CTD
PMID:11306436 PMID:12475806 PMID:21797767
NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
G
Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
increases expression
ISO
Asbestos, Amosite results in increased expression of PIK3CG mRNA
CTD
PMID:29112861
NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
G
Plekhg5
pleckstrin homology and RhoGEF domain containing G5
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PLEKHG5 promoter
CTD
PMID:29626692
NCBI chr 5:162,577,999...162,621,518
Ensembl chr 5:162,578,071...162,621,513
G
Potefam1
POTE ankyrin domain family member 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of ANKRD30A promoter
CTD
PMID:29626692
NCBI chr 3:97,641,258...97,826,965
Ensembl chr 3:97,641,261...97,826,949
G
Pou2f2
POU class 2 homeobox 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of POU2F2 promoter
CTD
PMID:29626692
NCBI chr 1:80,682,330...80,769,756
Ensembl chr 1:80,685,741...80,724,261
G
Prkaa2
protein kinase AMP-activated catalytic subunit alpha 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PRKAA2 promoter
CTD
PMID:29626692
NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
G
Prrx2
paired related homeobox 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of PRRX2 promoter
CTD
PMID:29626692
NCBI chr 3:14,132,574...14,168,533
Ensembl chr 3:14,094,004...14,168,535
G
Prss3
serine protease 3
increases methylation
ISO
Asbestos, Amosite results in increased methylation of PRSS3 gene
CTD
PMID:32062310
NCBI chr 4:70,203,088...70,206,562
Ensembl chr 4:70,203,088...70,206,562
G
Ptk2
protein tyrosine kinase 2
increases activity
ISO
Asbestos, Amosite results in increased activity of PTK2 protein
CTD
PMID:29112861
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
G
Ripk3
receptor-interacting serine-threonine kinase 3
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of RIPK3 promoter
CTD
PMID:29626692
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
G
Rnf146
ring finger protein 146
increases methylation
ISO
Asbestos, Amosite results in increased methylation of RNF146 promoter
CTD
PMID:29626692
NCBI chr 1:28,458,864...28,475,758
Ensembl chr 1:28,458,887...28,475,923
G
Rps27a
ribosomal protein S27a
decreases expression
ISO
Asbestos, Amosite results in decreased expression of RPS27A mRNA
CTD
PMID:23917077
NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011 Ensembl chr 5:103,285,734...103,288,011
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Rps6
ribosomal protein S6
increases expression
EXP
Asbestos, Amosite results in increased expression of RPS6 protein modified form
CTD
PMID:27083413
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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Satb2
SATB homeobox 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of SATB2 promoter
CTD
PMID:29626692
NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707
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Sbds
Sbds, ribosome maturation factor
increases methylation
ISO
Asbestos, Amosite results in increased methylation of SBDS promoter
CTD
PMID:29626692
NCBI chr12:26,420,410...26,429,650
Ensembl chr12:26,420,414...26,429,649
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Serac1
serine active site containing 1
increases methylation
ISO
Asbestos, Amosite results in increased methylation of SERAC1 promoter
CTD
PMID:29626692
NCBI chr 1:46,620,741...46,656,801
Ensembl chr 1:46,620,498...46,656,727
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Sgk1
serum/glucocorticoid regulated kinase 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of SGK1 promoter
CTD
PMID:29626692
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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Slco3a1
solute carrier organic anion transporter family, member 3a1
decreases expression
ISO
Asbestos, Amosite results in decreased expression of SLCO3A1 mRNA
CTD
PMID:23917077
NCBI chr 1:128,106,232...128,388,043
Ensembl chr 1:128,106,228...128,387,925
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Sod2
superoxide dismutase 2
multiple interactions
ISO
[Asbestos, Amosite co-treated with TNF protein] results in increased activity of SOD2 protein; [Asbestos, Amosite co-treated with TNF protein] results in increased expression of SOD2 mRNA
CTD
PMID:8817062
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
increases activity
ISO
Asbestos, Amosite results in increased activity of SRC protein
CTD
PMID:29112861
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Stat3
signal transducer and activator of transcription 3
increases expression increases activity
EXP ISO
Asbestos, Amosite results in increased expression of STAT3 protein modified form Asbestos, Amosite results in increased expression of STAT3 mRNA Asbestos, Amosite results in increased activity of STAT3 protein
CTD
PMID:27083413 PMID:29112861
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tbr1
T-box brain transcription factor 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of TBR1 promoter
CTD
PMID:29626692
NCBI chr 3:46,350,237...46,368,397
Ensembl chr 3:46,351,213...46,361,041
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Tbx4
T-box transcription factor 4
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of TBX4 promoter
CTD
PMID:29626692
NCBI chr10:70,730,686...70,760,829
Ensembl chr10:70,731,163...70,760,825
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Tgfb1
transforming growth factor, beta 1
increases expression decreases expression multiple interactions
EXP
Asbestos, Amosite results in increased expression of TGFB1 mRNA Asbestos, Amosite results in decreased expression of TGFB1 mRNA 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Amosite results in increased expression of TGFB1 mRNA]; Deferoxamine inhibits the reaction [Asbestos, Amosite results in increased expression of TGFB1 mRNA]; Iron promotes the reaction [Asbestos, Amosite results in increased expression of TGFB1 mRNA]; tetramethylthiourea inhibits the reaction [Asbestos, Amosite results in increased expression of TGFB1 mRNA]
CTD
PMID:11306436 PMID:12475806 PMID:21797767
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tiam2
TIAM Rac1 associated GEF 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of TIAM2 promoter
CTD
PMID:29626692
NCBI chr 1:43,918,179...44,119,499
Ensembl chr 1:43,918,174...44,119,493
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Timp3
TIMP metallopeptidase inhibitor 3
decreases expression
ISO
Asbestos, Amosite results in decreased expression of TIMP3 mRNA
CTD
PMID:23917077
NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
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Tlx2
T-cell leukemia homeobox 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of TLX2 promoter
CTD
PMID:29626692
NCBI chr 4:115,573,736...115,576,097
Ensembl chr 4:115,573,799...115,575,642
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Tnf
tumor necrosis factor
increases expression multiple interactions increases secretion
EXP ISO
Asbestos, Amosite results in increased expression of TNF protein [Asbestos, Amosite co-treated with TNF protein] results in increased activity of SOD2 protein; [Asbestos, Amosite co-treated with TNF protein] results in increased expression of SOD2 mRNA; [Asbestos, Amosite co-treated with TNF protein] results in increased metabolism of Adenosine Triphosphate; [Asbestos, Amosite co-treated with TNF protein] results in increased susceptibility to Vitamin K 3; Vitamin K 3 promotes the reaction [[Asbestos, Amosite co-treated with TNF protein] results in increased metabolism of Adenosine Triphosphate] Asbestos, Amosite results in increased expression of TNF mRNA Asbestos, Amosite results in increased secretion of TNF protein
CTD
PMID:8473757 PMID:8817062 PMID:27083413
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
affects localization multiple interactions increases expression increases response to substance
ISO EXP
Asbestos, Amosite affects the localization of TP53 protein Asbestos, Amosite results in increased susceptibility to [NF2 protein mutant form co-treated with CDKN2A protein mutant form co-treated with TRP53 protein mutant form] Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein] TP53 protein results in increased susceptibility to Asbestos, Amosite Deferoxamine inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]; Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]; Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein]; Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA] Asbestos, Amosite results in increased expression of TP53 mRNA; Asbestos, Amosite results in increased expression of TP53 protein
CTD
PMID:16357363 PMID:37441092
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Ttyh1
tweety family member 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of TTYH1 promoter
CTD
PMID:29626692
NCBI chr 1:70,053,312...70,071,872
Ensembl chr 1:70,053,324...70,071,845
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Ttyh2
tweety family member 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of TTYH2 promoter
CTD
PMID:29626692
NCBI chr10:99,709,063...99,753,449
Ensembl chr10:99,709,007...99,753,444
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Ttyh3
tweety family member 3
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of TTYH3 promoter
CTD
PMID:29626692
NCBI chr12:13,996,831...14,025,457
Ensembl chr12:13,997,045...14,025,459
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Ubp1
upstream binding protein 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of UBP1 promoter
CTD
PMID:29626692
NCBI chr 8:113,869,771...113,915,625
Ensembl chr 8:113,869,979...113,915,625
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Ushbp1
USH1 protein network component harmonin binding protein 1
decreases expression
ISO
Asbestos, Amosite results in decreased expression of USHBP1 mRNA
CTD
PMID:23917077
NCBI chr16:18,057,321...18,067,933
Ensembl chr16:18,057,326...18,067,877
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Usp37
ubiquitin specific peptidase 37
increases methylation
ISO
Asbestos, Amosite results in increased methylation of USP37 promoter
CTD
PMID:29626692
NCBI chr 9:76,018,863...76,118,732
Ensembl chr 9:76,018,991...76,084,044
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Vax1
ventral anterior homeobox 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of VAX1 promoter
CTD
PMID:29626692
NCBI chr 1:258,324,571...258,342,396
Ensembl chr 1:258,326,276...258,330,192
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Vax2
ventral anterior homeobox 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of VAX2 promoter
CTD
PMID:29626692
NCBI chr 4:116,195,528...116,219,597
Ensembl chr 4:116,195,528...116,219,594
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Ventx
VENT homeobox
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of VENTX promoter
CTD
PMID:29626692
NCBI chr X:86,483,893...86,484,900
Ensembl chr X:86,483,893...86,484,954
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Vrk3
VRK serine/threonine kinase 3
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of VRK3 promoter
CTD
PMID:29626692
NCBI chr 1:95,243,344...95,270,780
Ensembl chr 1:95,243,364...95,270,780
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Vsx1
visual system homeobox 1
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of VSX1 promoter
CTD
PMID:29626692
NCBI chr 3:139,514,270...139,521,869
Ensembl chr 3:139,514,270...139,521,869
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Vsx2
visual system homeobox 2
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of VSX2 promoter
CTD
PMID:29626692
NCBI chr 6:104,214,842...104,240,264
Ensembl chr 6:104,217,230...104,240,018
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Wnk4
WNK lysine deficient protein kinase 4
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of WNK4 promoter
CTD
PMID:29626692
NCBI chr10:86,202,552...86,219,655
Ensembl chr10:86,188,812...86,231,829
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Wnt10a
Wnt family member 10A
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of WNT10A promoter
CTD
PMID:29626692
NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400
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Wnt11
Wnt family member 11
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of WNT11 promoter
CTD
PMID:29626692
NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294
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Wnt5b
Wnt family member 5B
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of WNT5B promoter
CTD
PMID:29626692
NCBI chr 4:152,609,566...152,733,790
Ensembl chr 4:152,609,569...152,733,407
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Wnt7a
Wnt family member 7A
decreases methylation
ISO
Asbestos, Amosite results in decreased methylation of WNT7A promoter
CTD
PMID:29626692
NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981
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Xbp1
X-box binding protein 1
multiple interactions increases expression
ISO
Asbestos, Amosite results in increased expression of and affects the splicing of XBP1 mRNA; BCL2L1 protein inhibits the reaction [Asbestos, Amosite results in increased expression of XBP1 protein alternative form]
CTD
PMID:23885834
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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Zcwpw2
zinc finger CW-type and PWWP domain containing 2
decreases expression
ISO
Asbestos, Amosite results in decreased expression of ZCWPW2 mRNA
CTD
PMID:23917077
NCBI chr 8:117,628,838...117,773,096
Ensembl chr 8:117,681,238...117,773,739
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Zzz3
zinc finger, ZZ-type containing 3
increases methylation
ISO
Asbestos, Amosite results in increased methylation of ZZZ3 promoter
CTD
PMID:29626692
NCBI chr 2:241,330,366...241,397,308
Ensembl chr 2:241,331,022...241,397,307
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