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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:S-(1,2-dichlorovinyl)-L-cysteine
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Accession:CHEBI:46650 term browser browse the term
Definition:An L-alpha-amino acid that is L-cysteine in which the hydrogen attached to the sulfur is replaced by a 1,2-dichlorovinyl group.
Synonyms:exact_synonym: (2R)-2-amino-3-[(1,2-dichloroethenyl)sulfanyl]propanoic acid;   S-(1,2-dichloroethenyl)-L-cysteine
 related_synonym: 3-((1,2-dichlorovinyl)thio)-L-alanine;   Formula=C5H7Cl2NO2S;   InChI=1S/C5H7Cl2NO2S/c6-1-4(7)11-2-3(8)5(9)10/h1,3H,2,8H2,(H,9,10)/t3-/m0/s1;   InChIKey=PJIHCWJOTSJIPQ-VKHMYHEASA-N;   SMILES=[H]C(Cl)=C(Cl)SC[C@H](N)C(O)=O
 xref: Beilstein:6582125;   CAS:627-72-5
 xref_mesh: MESH:C039961


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S-(1,2-dichlorovinyl)-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of APAF1 protein CTD PMID:15967204 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of BAX protein CTD PMID:15967204 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of BCL2 protein CTD PMID:15967204 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO alpha-Tocopherol inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP3 protein] CTD PMID:29129777 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP7 protein
alpha-Tocopherol inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP7 protein]
CTD PMID:29129777 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases activity ISO S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP8 protein CTD PMID:29129777 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity
ISO S-(1,2-dichlorovinyl)cysteine results in increased cleavage of CASP9 protein
S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP9 protein
CTD PMID:15967204 PMID:29129777 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of CCND1 protein CTD PMID:16495211 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of CDK4 protein CTD PMID:16495211 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of CDK6 protein CTD PMID:16495211 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO S-(1,2-dichlorovinyl)cysteine results in decreased expression of CDKN2A protein CTD PMID:16495211 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions
decreases activity
EXP Aminooxyacetic Acid inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in decreased activity of DLD protein] CTD PMID:2360207 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP S-(1,2-dichlorovinyl)cysteine results in decreased activity of GSR protein CTD PMID:2360207 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of JUN protein CTD PMID:15967204 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO S-(1,2-dichlorovinyl)cysteine results in increased cleavage of PARP1 protein CTD PMID:15967204 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha increases phosphorylation
decreases expression
ISO S-(1,2-dichlorovinyl)cysteine results in increased phosphorylation of PPP1CA protein
S-(1,2-dichlorovinyl)cysteine results in decreased expression of PPP1CA protein
CTD PMID:16495211 NCBI chr 1:219,439,953...219,443,570
Ensembl chr 1:219,439,953...219,443,570
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation ISO S-(1,2-dichlorovinyl)cysteine results in increased phosphorylation of RB1 protein CTD PMID:16495211 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of RELA protein CTD PMID:15967204 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc25a10 solute carrier family 25 member 10 multiple interactions EXP [SLC25A10 protein co-treated with Glutathione] results in decreased susceptibility to S-(1,2-dichlorovinyl)cysteine CTD PMID:12388626 NCBI chr10:109,665,682...109,674,782
Ensembl chr10:109,665,682...109,673,143
JBrowse link
G Tp53 tumor protein p53 increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of TP53 protein CTD PMID:15967204 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vim vimentin increases expression EXP S-(1,2-dichlorovinyl)cysteine results in increased expression of VIM mRNA CTD PMID:10996665 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    chemical entity 19761
      molecular entity 19759
        polyatomic entity 19677
          heteroatomic molecular entity 19607
            halide 18071
              organohalogen compound 17838
                organochlorine compound 17639
                  S-(1,2-dichlorovinyl)-L-cysteine 21
                    S-(cis-1,2-dichlorovinyl)-L-cysteine 0
                    S-(trans-1,2-dichlorovinyl)-L-cysteine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic acid 18151
                                        amino acid 14107
                                          alpha-amino acid 11593
                                            L-alpha-amino acid 11428
                                              serine family amino acid 2061
                                                L-cysteine 1144
                                                  L-cysteine derivative 1134
                                                    S-substituted L-cysteine 148
                                                      L-cysteine thioether 66
                                                        S-(1,2-dichlorovinyl)-L-cysteine 21
                                                          S-(cis-1,2-dichlorovinyl)-L-cysteine 0
                                                          S-(trans-1,2-dichlorovinyl)-L-cysteine 0
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