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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitrite salt
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Accession:CHEBI:46648 term browser browse the term


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sodium nitrite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO [Hypochlorous Acid co-treated with Sodium Nitrite] results in decreased activity of ACHE protein
Sodium Nitrite results in decreased activity of ACHE protein
CTD PMID:12414318, PMID:26231821 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acp1 acid phosphatase 1 increases activity ISO Sodium Nitrite results in increased activity of ACP1 protein CTD PMID:26231821 NCBI chr 6:49,836,064...49,851,714
Ensembl chr 6:49,836,075...49,851,714
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of AKT1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of AKT1 protein]
CTD PMID:28266762 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases activity ISO Sodium Nitrite results in increased activity of AMPD3 protein CTD PMID:26231821 NCBI chr 1:175,585,301...175,630,479
Ensembl chr 1:175,586,097...175,630,467
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme] CTD PMID:25211009 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of BAX mRNA; Sodium Nitrite results in increased expression of BAX protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]
CTD PMID:28000380, PMID:28266762, PMID:28833918 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP Sodium Nitrite results in decreased expression of BCL2 mRNA; Sodium Nitrite results in decreased expression of BCL2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]
CTD PMID:28000380, PMID:28266762, PMID:28833918 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP Sodium Nitrite results in increased activity of CASP3 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of CASP3 protein]
CTD PMID:28833918 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases activity
increases activity
ISO Sodium Nitrite results in decreased activity of CAT protein
Sodium Nitrite results in increased activity of CAT protein
CTD PMID:26231821, PMID:31476334 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Sodium Nitrite results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Sodium Nitrite results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Crp C-reactive protein multiple interactions
increases expression
EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of CRP protein] CTD PMID:28266762, PMID:28833918 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO Sodium Nitrite results in decreased activity of G6PD protein CTD PMID:26231821 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of GPT protein] CTD PMID:28833918 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO Sodium Nitrite results in decreased activity of GSR protein CTD PMID:26231821 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Sodium Nitrite results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of HIF1A protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]
CTD PMID:28000380, PMID:28266762 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
ISO Sodium Nitrite results in increased expression of IL1B mRNA
Sodium Nitrite results in increased secretion of IL1B protein
CTD PMID:16581224 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Sodium Nitrite results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
multiple interactions
ISO
EXP
Sodium Nitrite results in increased secretion of IL6 protein
Sodium Nitrite results in increased expression of IL6 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of IL6 protein]
CTD PMID:16581224, PMID:28266762 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ldhb lactate dehydrogenase B increases activity ISO Sodium Nitrite results in increased activity of LDHB protein CTD PMID:26231821 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Sodium Nitrite results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression
EXP Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of NFKBIA mRNA] CTD PMID:28833918 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Sodium Nitrite results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
JBrowse link
G Smad2 SMAD family member 2 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of SMAD2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]
CTD PMID:28000380, PMID:28266762 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Stmn1 stathmin 1 increases expression ISO Sodium Nitrite results in increased expression of STMN1 protein CTD PMID:20025956 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of TGFB1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein]
CTD PMID:28266762 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion
ISO
EXP
Sodium Nitrite results in increased expression of TNF mRNA
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]
Sodium Nitrite results in increased secretion of TNF protein
CTD PMID:16581224, PMID:28266762, PMID:28833918 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of VEGFA protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of VEGFA protein]
CTD PMID:28266762 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          nitrogen atom 18539
            nitrogen molecular entity 18539
              nitrites 58
                nitrite salt 29
                  sodium nitrite 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                pnictogen oxoacid 10144
                                  nitrogen oxoacid 274
                                    nitrous acid 58
                                      nitrites 58
                                        nitrite salt 29
                                          sodium nitrite 29
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.