diketone - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	diketone	go back to main search page
Accession:	CHEBI:46640	browse the term
Definition:	A compound that contains two ketone functionalities.
Synonyms:	exact_synonym:	diketones
	xref:	Wikipedia:Diketone

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Rat (1262) Mouse (1264) Human (1282) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (1) Green Monkey (0) Naked Mole-rat (0) All
Genes (1282)

1-phenyl-1,2-propanedione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1 member C2

increases expression

1-phenyl-1,2-propanedione results in increased expression of AKR1C2 mRNA

NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031

G

cytochrome P450 family 1 subfamily A member 1

increases expression

1-phenyl-1,2-propanedione results in increased expression of CYP1A1 mRNA

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

dehydrogenase/reductase 11

increases reduction

DHRS11 protein results in increased reduction of 1-phenyl-1,2-propanedione

NCBI chr17:36,591,879...36,600,804
Ensembl chr17:36,591,879...36,600,804

G

dehydrogenase/reductase 2

multiple interactions

[NADP co-treated with DHRS2 protein] affects the metabolism of 1-phenyl-1,2-propanedione

NCBI chr14:23,630,115...23,645,639
Ensembl chr14:23,630,115...23,645,639

G

heme oxygenase 1

increases expression

1-phenyl-1,2-propanedione results in increased expression of HMOX1 mRNA

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

MAF bZIP transcription factor F

increases expression

1-phenyl-1,2-propanedione results in increased expression of MAFF mRNA

NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507

2,5-hexanedione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

abl interactor 2

increases expression

2,5-hexanedione results in increased expression of ABI2 mRNA

PMID:22952946 PMID:27466211

NCBI chr 2:203,328,394...203,432,169
Ensembl chr 2:203,328,280...203,447,728

G

aconitase 2

increases expression

2,5-hexanedione results in increased expression of ACO2 protein

NCBI chr22:41,469,117...41,528,974
Ensembl chr22:41,447,830...41,529,273

G

allograft inflammatory factor 1

multiple interactions
increases expression

Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of AIF1 protein]

PMID:32522579 PMID:32860822

NCBI chr 6:31,615,234...31,617,015
Ensembl chr 6:31,615,217...31,617,021

G

AKT serine/threonine kinase 1

increases expression
decreases phosphorylation

2,5-hexanedione results in increased expression of AKT1 mRNA
2,5-hexanedione results in decreased phosphorylation of AKT1 protein

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

arachidonate 15-lipoxygenase type B

decreases expression

2,5-hexanedione results in decreased expression of ALOX15B mRNA

NCBI chr17:8,039,059...8,049,134
Ensembl chr17:8,039,034...8,049,134

G

angiopoietin like 4

affects expression

2,5-hexanedione affects the expression of ANGPTL4 mRNA

NCBI chr19:8,364,155...8,374,370
Ensembl chr19:8,363,289...8,374,370

G

arginase 1

decreases expression
multiple interactions

2,5-hexanedione results in decreased expression of ARG1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of ARG1 mRNA]

PMID:32522579 PMID:32860822

NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332

G

BCL2 associated X, apoptosis regulator

increases expression

2,5-hexanedione results in increased expression of BAX mRNA; 2,5-hexanedione results in increased expression of BAX protein

PMID:17492505 PMID:21901545 PMID:22337490

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

increases expression
decreases expression

2,5-hexanedione results in increased expression of BCL2 protein
2,5-hexanedione results in decreased expression of BCL2 mRNA
2,5-hexanedione results in decreased expression of BCL2 mRNA; 2,5-hexanedione results in decreased expression of BCL2 protein

PMID:17492505 PMID:21901545 PMID:22337490

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 14

increases expression

2,5-hexanedione results in increased expression of BCL2L14 mRNA

NCBI chr12:12,049,861...12,099,695
Ensembl chr12:12,049,844...12,211,084

G

brain derived neurotrophic factor

decreases expression

2,5-hexanedione results in decreased expression of BDNF protein

NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058

G

bifunctional apoptosis regulator

increases expression

2,5-hexanedione results in increased expression of BFAR mRNA

NCBI chr16:14,632,951...14,669,236
Ensembl chr16:14,632,931...14,669,236

G

caspase 1

multiple interactions
increases expression
increases cleavage

Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of CASP1 protein]
2,5-hexanedione results in increased expression of CASP1 mRNA

PMID:32522579 PMID:32860822

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 3

increases expression

2,5-hexanedione results in increased expression of CASP3 mRNA; 2,5-hexanedione results in increased expression of CASP3 protein alternative form

PMID:17492505 PMID:21901545

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

decreases expression

2,5-hexanedione results in decreased expression of CASP8 protein

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

coiled-coil domain containing 171

increases expression

2,5-hexanedione results in increased expression of CCDC171 mRNA

NCBI chr 9:15,552,885...16,108,926
Ensembl chr 9:15,553,043...16,061,663

G

coiled-coil domain containing 191

increases expression

2,5-hexanedione results in increased expression of CCDC191 mRNA

NCBI chr 3:113,964,137...114,056,613
Ensembl chr 3:113,964,137...114,056,594

G

CDAN1 interacting nuclease 1

increases expression

2,5-hexanedione results in increased expression of CDIN1 mRNA

NCBI chr15:36,579,626...36,810,244
Ensembl chr15:36,579,626...36,810,248

G

centrosomal protein 112

increases expression

2,5-hexanedione results in increased expression of CEP112 mRNA

NCBI chr17:65,635,537...66,192,133
Ensembl chr17:65,635,537...66,192,133

G

cilia and flagella associated protein 221

increases expression

2,5-hexanedione results in increased expression of CFAP221 mRNA

NCBI chr 2:119,544,449...119,660,323
Ensembl chr 2:119,544,432...119,662,251

G

creatine kinase, mitochondrial 1B

increases expression

2,5-hexanedione results in increased expression of CKMT1B protein

NCBI chr15:43,592,857...43,599,406
Ensembl chr15:43,593,054...43,604,901
Ensembl chr15:43,593,054...43,604,901

G

chloride channel accessory 2

multiple interactions

[carbendazim co-treated with 2,5-hexanedione] results in decreased expression of CLCA2 mRNA

NCBI chr 1:86,424,171...86,456,553
Ensembl chr 1:86,424,171...86,456,553

G

clusterin

decreases expression
increases expression

2,5-hexanedione results in decreased expression of CLU mRNA
2,5-hexanedione results in increased expression of CLU mRNA

PMID:22952946 PMID:27466211

NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700

G

cortexin 1

increases expression

2,5-hexanedione results in increased expression of CTXN1 mRNA

NCBI chr19:7,924,491...7,926,135
Ensembl chr19:7,924,491...7,926,135

G

decorin

increases expression

2,5-hexanedione results in increased expression of DCN mRNA

NCBI chr12:91,140,484...91,182,817
Ensembl chr12:91,140,484...91,183,217

G

DENN domain containing 1A

increases expression

2,5-hexanedione results in increased expression of DENND1A mRNA

NCBI chr 9:123,379,658...123,930,126
Ensembl chr 9:123,379,654...123,930,152

G

dicer 1, ribonuclease III

increases expression

2,5-hexanedione results in increased expression of DICER1 mRNA

NCBI chr14:95,086,228...95,158,010
Ensembl chr14:95,086,228...95,158,010

G

dynein axonemal assembly factor 11

increases expression

2,5-hexanedione results in increased expression of DNAAF11 mRNA

NCBI chr 8:132,570,416...132,702,913
Ensembl chr 8:132,570,416...132,675,592

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

2,5-hexanedione results in increased expression of DNAJB4 mRNA

NCBI chr 1:77,979,175...78,017,964
Ensembl chr 1:77,979,175...78,017,964

G

dipeptidyl peptidase 7

multiple interactions

[carbendazim co-treated with 2,5-hexanedione] results in decreased expression of DPP7 mRNA

NCBI chr 9:137,110,546...137,118,306
Ensembl chr 9:137,110,542...137,118,309

G

dihydropyrimidinase like 2

decreases expression

2,5-hexanedione results in decreased expression of DPYSL2 protein

NCBI chr 8:26,514,031...26,658,175
Ensembl chr 8:26,514,031...26,658,178

G

epidermal growth factor receptor

increases expression

2,5-hexanedione results in increased expression of EGFR mRNA

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

ELKS/RAB6-interacting/CAST family member 1

increases expression

2,5-hexanedione results in increased expression of ERC1 mRNA

NCBI chr12:989,959...1,495,933
Ensembl chr12:990,509...1,495,933

G

Fas ligand

increases expression

2,5-hexanedione results in increased expression of FASLG mRNA

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

fatty acid synthase

decreases expression

2,5-hexanedione results in decreased expression of FASN protein

NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294

G

Fc epsilon receptor Ig

increases expression

2,5-hexanedione results in increased expression of FCER1G mRNA

NCBI chr 1:161,215,295...161,219,245
Ensembl chr 1:161,215,234...161,220,699

G

forkhead box O3

increases phosphorylation
decreases expression

2,5-hexanedione results in increased phosphorylation of FOXO3 protein
2,5-hexanedione results in decreased expression of FOXO3 mRNA

NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774

G

growth arrest and DNA damage inducible alpha

increases expression

2,5-hexanedione results in increased expression of GADD45 mRNA

NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334

G

growth arrest specific 2

increases expression

2,5-hexanedione results in increased expression of GAS2 mRNA

NCBI chr11:22,626,002...22,813,055
Ensembl chr11:22,625,509...22,813,001

G

glial fibrillary acidic protein

decreases expression
increases expression

2,5-hexanedione results in decreased expression of GFAP protein
2,5-hexanedione results in increased expression of GFAP protein

NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937

G

growth hormone secretagogue receptor

affects expression

2,5-hexanedione affects the expression of GHSR mRNA

NCBI chr 3:172,443,291...172,448,456
Ensembl chr 3:172,443,291...172,448,456

G

glutamate dehydrogenase 1

increases expression

2,5-hexanedione results in increased expression of GLUD1 protein

NCBI chr10:87,050,202...87,094,843
Ensembl chr10:87,050,202...87,094,843

G

gasdermin D

increases cleavage
multiple interactions

2,5-hexanedione results in increased cleavage of GSDMD protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of GSDMD protein]

PMID:32522579 PMID:32860822

NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062

G

glycogen synthase kinase 3 beta

decreases expression

2,5-hexanedione results in decreased expression of GSK3B protein

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

gelsolin

decreases expression

2,5-hexanedione results in decreased expression of GSN protein

NCBI chr 9:121,201,483...121,332,842
Ensembl chr 9:121,207,794...121,332,843

G

glutathione S-transferase mu 5

decreases expression

2,5-hexanedione results in decreased expression of GSTM5 protein

NCBI chr 1:109,711,751...109,718,268
Ensembl chr 1:109,711,780...109,775,428

G

glutathione S-transferase pi 1

decreases expression

2,5-hexanedione results in decreased expression of GSTP1 mRNA

NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656

G

HDGF like 1

decreases expression

2,5-hexanedione results in decreased expression of HDGFL1 mRNA

NCBI chr 6:22,569,566...22,571,666
Ensembl chr 6:22,569,566...22,571,666

G

heat shock protein family A (Hsp70) member 1B

increases expression

2,5-hexanedione results in increased expression of HSPA1B mRNA

NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254

G

immediate early response 3

affects expression

2,5-hexanedione affects the expression of IER3 mRNA

NCBI chr 6:30,743,199...30,744,547
Ensembl chr 6:30,743,199...30,744,548

G

intraflagellar transport 81

increases expression

2,5-hexanedione results in increased expression of IFT81 mRNA

NCBI chr12:110,124,357...110,218,793
Ensembl chr12:110,124,335...110,218,793

G

insulin like growth factor binding protein 3

decreases expression

2,5-hexanedione results in decreased expression of IGFBP3 mRNA

NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874

G

interleukin 1 beta

increases expression
multiple interactions

2,5-hexanedione results in increased expression of IL1B mRNA; 2,5-hexanedione results in increased expression of IL1B protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of IL1B protein]

PMID:16141653 PMID:32522579 PMID:32860822

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

internexin neuronal intermediate filament protein alpha

decreases expression

2,5-hexanedione results in decreased expression of INA protein

NCBI chr10:103,277,138...103,290,346
Ensembl chr10:103,277,138...103,290,346

G

integrin subunit alpha M

increases expression
multiple interactions

2,5-hexanedione results in increased expression of ITGAM protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of ITGAM protein]

PMID:19464574 PMID:32522579 PMID:32860822

NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892

G

integrin subunit beta 1

decreases expression

2,5-hexanedione results in decreased expression of ITGB1 mRNA

NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792

G

KIAA0930

increases expression

2,5-hexanedione results in increased expression of KIAA0930 mRNA

NCBI chr22:45,192,244...45,240,894
Ensembl chr22:45,192,244...45,240,894

G

KIAA1328

increases expression

2,5-hexanedione results in increased expression of KIAA1328 mRNA

NCBI chr18:36,829,127...37,232,172
Ensembl chr18:36,829,106...37,232,172

G

kinesin family member 6

increases expression

2,5-hexanedione results in increased expression of KIF6 mRNA

NCBI chr 6:39,329,990...39,725,408
Ensembl chr 6:39,329,990...39,725,408

G

KIT proto-oncogene, receptor tyrosine kinase

decreases expression
multiple interactions

2,5-hexanedione results in decreased expression of KIT protein
resveratrol inhibits the reaction [2,5-hexanedione results in decreased expression of KIT protein]

NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783

G

lysyl oxidase like 1

increases expression
multiple interactions

2,5-hexanedione results in increased expression of LOXL1 protein
2,5-hexanedione promotes the reaction [carbendazim results in increased expression of LOXL1 protein]; [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of LOXL1 mRNA

NCBI chr15:73,926,462...73,952,136
Ensembl chr15:73,925,989...73,952,137

G

leucine rich repeat containing 69

increases expression

2,5-hexanedione results in increased expression of LRRC69 mRNA

NCBI chr 8:91,102,619...91,219,257
Ensembl chr 8:91,101,832...91,219,257

G

lysozyme

decreases expression
increases expression

2,5-hexanedione results in decreased expression of LYZ2 mRNA
2,5-hexanedione results in increased expression of LYZ2 mRNA

NCBI chr12:69,348,381...69,354,234
Ensembl chr12:69,348,381...69,354,234

G

mono-ADP ribosylhydrolase 1

increases expression
multiple interactions

2,5-hexanedione results in increased expression of MACROD1 mRNA
[carbendazim co-treated with 2,5-hexanedione] results in decreased expression of MACROD1 mRNA

NCBI chr11:63,998,558...64,166,113
Ensembl chr11:63,998,558...64,166,113

G

microtubule associated protein 1A

decreases expression

2,5-hexanedione results in decreased expression of MAP1A protein

NCBI chr15:43,510,954...43,531,611
Ensembl chr15:43,510,958...43,531,620

G

microtubule associated protein 1B

decreases expression

2,5-hexanedione results in decreased expression of MAP1B protein; 2,5-hexanedione results in decreased expression of MAP1B protein modified form

PMID:20554699 PMID:31760062

NCBI chr 5:72,107,475...72,209,565
Ensembl chr 5:72,107,234...72,209,565

G

microtubule associated protein 2

decreases expression

2,5-hexanedione results in decreased expression of MAP2 protein modified form

NCBI chr 2:209,424,047...209,734,112
Ensembl chr 2:209,424,047...209,734,147

G

mitogen-activated protein kinase kinase kinase 1

increases expression

2,5-hexanedione results in increased expression of MAP3K1 protein

NCBI chr 5:56,815,549...56,896,152
Ensembl chr 5:56,815,549...56,896,152

G

microtubule associated protein tau

decreases expression

2,5-hexanedione results in decreased expression of MAPT protein modified form

NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334

G

myelin basic protein

multiple interactions
decreases expression

Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MBP protein]

PMID:32522579 PMID:32860822

NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683

G

malate dehydrogenase 1

increases expression

2,5-hexanedione results in increased expression of MDH1 protein

NCBI chr 2:63,588,963...63,607,197
Ensembl chr 2:63,588,609...63,607,197

G

microfibril associated protein 3 like

increases expression

2,5-hexanedione results in increased expression of MFAP3L mRNA

NCBI chr 4:169,986,602...170,027,277
Ensembl chr 4:169,986,597...170,033,031

G

microRNA 10b

increases expression

2,5-hexanedione results in increased expression of MIR10B mRNA

NCBI chr 2:176,150,303...176,150,412
Ensembl chr 2:176,150,303...176,150,412

G

microRNA 1224

increases expression

2,5-hexanedione results in increased expression of MIR1224 mRNA

NCBI chr 3:184,241,405...184,241,489
Ensembl chr 3:184,241,405...184,241,489

G

microRNA 125a

increases expression
decreases expression

2,5-hexanedione results in increased expression of MIR125A mRNA
2,5-hexanedione results in decreased expression of MIR125A mRNA

NCBI chr19:51,693,254...51,693,339
Ensembl chr19:51,693,254...51,693,339

G

microRNA 130b

decreases expression

2,5-hexanedione results in decreased expression of MIR130B mRNA

NCBI chr22:21,653,304...21,653,385
Ensembl chr22:21,653,304...21,653,385

G

microRNA 134

decreases expression

2,5-hexanedione results in decreased expression of MIR134 mRNA

NCBI chr14:101,054,687...101,054,759
Ensembl chr14:101,054,687...101,054,759

G

microRNA 155

decreases expression

2,5-hexanedione results in decreased expression of MIR155 mRNA

NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044

G

microRNA 183

decreases expression

2,5-hexanedione results in decreased expression of MIR183 mRNA

NCBI chr 7:129,774,905...129,775,014
Ensembl chr 7:129,774,905...129,775,014

G

microRNA 193a

decreases expression

2,5-hexanedione results in decreased expression of MIR193A mRNA

NCBI chr17:31,559,996...31,560,083
Ensembl chr17:31,559,996...31,560,083

G

microRNA 194-2

decreases expression

2,5-hexanedione results in decreased expression of MIR194-2 mRNA

NCBI chr11:64,891,355...64,891,439
Ensembl chr11:64,891,355...64,891,439

G

microRNA 196a-1

increases expression

2,5-hexanedione results in increased expression of MIR196C mRNA

NCBI chr17:48,632,490...48,632,559
Ensembl chr17:48,632,490...48,632,559

G

microRNA 196a-2

increases expression

2,5-hexanedione results in increased expression of MIR196A mRNA

NCBI chr12:53,991,738...53,991,847
Ensembl chr12:53,991,738...53,991,847

G

microRNA 199a-2

decreases expression

2,5-hexanedione results in decreased expression of MIR199A-2 mRNA; 2,5-hexanedione results in decreased expression of MIR199A2 mRNA

NCBI chr 1:172,144,535...172,144,644
Ensembl chr 1:172,144,535...172,144,644

G

microRNA 200c

decreases expression

2,5-hexanedione results in decreased expression of MIR200C mRNA

NCBI chr12:6,963,699...6,963,766
Ensembl chr12:6,963,699...6,963,766

G

microRNA 202

decreases expression

2,5-hexanedione results in decreased expression of MIR202 mRNA

NCBI chr10:133,247,511...133,247,620
Ensembl chr10:133,247,511...133,247,620

G

microRNA 206

decreases expression

2,5-hexanedione results in decreased expression of MIR206 mRNA

NCBI chr 6:52,144,349...52,144,434
Ensembl chr 6:52,144,349...52,144,434

G

microRNA 208a

increases expression

2,5-hexanedione results in increased expression of MIR208A mRNA

NCBI chr14:23,388,596...23,388,666
Ensembl chr14:23,388,596...23,388,666

G

microRNA 20a

decreases expression

2,5-hexanedione results in decreased expression of MIR20A mRNA

NCBI chr13:91,351,065...91,351,135
Ensembl chr13:91,351,065...91,351,135

G

microRNA 21

increases expression
decreases expression

2,5-hexanedione results in increased expression of MIR21 mRNA
2,5-hexanedione results in decreased expression of MIR21 mRNA

NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337

G

microRNA 212

increases expression

2,5-hexanedione results in increased expression of MIR212 mRNA

NCBI chr17:2,050,271...2,050,380
Ensembl chr17:2,050,271...2,050,380

G

microRNA 214

increases expression

2,5-hexanedione results in increased expression of MIR214 mRNA

NCBI chr 1:172,138,798...172,138,907
Ensembl chr 1:172,138,798...172,138,907

G

microRNA 22

increases expression

2,5-hexanedione results in increased expression of MIR22 mRNA

NCBI chr17:1,713,903...1,713,987
Ensembl chr17:1,713,903...1,713,987

G

microRNA 223

increases expression

2,5-hexanedione results in increased expression of MIR223 mRNA

NCBI chr X:66,018,870...66,018,979
Ensembl chr X:66,018,870...66,018,979

G

microRNA 224

increases expression

2,5-hexanedione results in increased expression of MIR224 mRNA

NCBI chr X:151,958,578...151,958,658
Ensembl chr X:151,958,578...151,958,658

G

microRNA 27a

decreases expression

2,5-hexanedione results in decreased expression of MIR27A mRNA

NCBI chr19:13,836,440...13,836,517
Ensembl chr19:13,836,440...13,836,517

G

microRNA 27b

increases expression

2,5-hexanedione results in increased expression of MIR27B mRNA

NCBI chr 9:95,085,445...95,085,541
Ensembl chr 9:95,085,445...95,085,541

G

microRNA 300

increases expression

2,5-hexanedione results in increased expression of MIR300 mRNA

NCBI chr14:101,041,363...101,041,445
Ensembl chr14:101,041,363...101,041,445

G

microRNA 30a

increases expression

2,5-hexanedione results in increased expression of MIR30A mRNA

NCBI chr 6:71,403,551...71,403,621
Ensembl chr 6:71,403,551...71,403,621

G

microRNA 32

increases expression

2,5-hexanedione results in increased expression of MIR32 mRNA

NCBI chr 9:109,046,229...109,046,298
Ensembl chr 9:109,046,229...109,046,298

G

microRNA 320a

increases expression

2,5-hexanedione results in increased expression of MIR320A mRNA

NCBI chr 8:22,244,966...22,245,037
Ensembl chr 8:22,244,962...22,245,043

G

microRNA 323a

decreases expression

2,5-hexanedione results in decreased expression of MIR323 mRNA

NCBI chr14:101,025,732...101,025,817
Ensembl chr14:101,025,732...101,025,817

G

microRNA 326

increases expression

2,5-hexanedione results in increased expression of MIR326 mRNA

NCBI chr11:75,335,092...75,335,186
Ensembl chr11:75,335,092...75,335,186

G

microRNA 330

increases expression

2,5-hexanedione results in increased expression of MIR330 mRNA

NCBI chr19:45,638,994...45,639,087
Ensembl chr19:45,638,994...45,639,087

G

microRNA 331

decreases expression

2,5-hexanedione results in decreased expression of MIR331 mRNA

NCBI chr12:95,308,420...95,308,513
Ensembl chr12:95,308,420...95,308,513

G

microRNA 339

increases expression

2,5-hexanedione results in increased expression of MIR339 mRNA

NCBI chr 7:1,022,933...1,023,026
Ensembl chr 7:1,022,933...1,023,026

G

microRNA 33a

increases expression

2,5-hexanedione results in increased expression of MIR33 mRNA

NCBI chr22:41,900,944...41,901,012
Ensembl chr22:41,900,944...41,901,012

G

microRNA 345

increases expression

2,5-hexanedione results in increased expression of MIR345 mRNA

NCBI chr14:100,307,859...100,307,956
Ensembl chr14:100,307,859...100,307,956

G

microRNA 370

decreases expression

2,5-hexanedione results in decreased expression of MIR370 mRNA

NCBI chr14:100,911,139...100,911,213
Ensembl chr14:100,911,139...100,911,213

G

microRNA 375

decreases expression

2,5-hexanedione results in decreased expression of MIR375 mRNA

NCBI chr 2:219,001,645...219,001,708
Ensembl chr 2:219,001,645...219,001,708

G

microRNA 412

increases expression

2,5-hexanedione results in increased expression of MIR412 mRNA

NCBI chr14:101,065,447...101,065,537
Ensembl chr14:101,065,447...101,065,537

G

microRNA 423

increases expression

2,5-hexanedione results in increased expression of MIR423 mRNA

NCBI chr17:30,117,079...30,117,172
Ensembl chr17:30,117,079...30,117,172

G

microRNA 433

decreases expression

2,5-hexanedione results in decreased expression of MIR433 mRNA

NCBI chr14:100,881,886...100,881,978
Ensembl chr14:100,881,886...100,881,978

G

microRNA 450a-1

decreases expression

2,5-hexanedione results in decreased expression of MIR450A1 mRNA

NCBI chr X:134,540,341...134,540,431
Ensembl chr X:134,540,341...134,540,431

G

microRNA 487b

increases expression

2,5-hexanedione results in increased expression of MIR487B mRNA

NCBI chr14:101,046,455...101,046,538
Ensembl chr14:101,046,455...101,046,538

G

microRNA 488

increases expression

2,5-hexanedione results in increased expression of MIR488 mRNA

NCBI chr 1:177,029,363...177,029,445
Ensembl chr 1:177,029,363...177,029,445

G

microRNA 497

decreases expression

2,5-hexanedione results in decreased expression of MIR497 mRNA

NCBI chr17:7,017,911...7,018,022
Ensembl chr17:7,017,911...7,018,022

G

microRNA 503

decreases expression

2,5-hexanedione results in decreased expression of MIR503 mRNA

NCBI chr X:134,546,328...134,546,398
Ensembl chr X:134,546,328...134,546,398

G

microRNA 541

decreases expression

2,5-hexanedione results in decreased expression of MIR541 mRNA

NCBI chr14:101,064,495...101,064,578
Ensembl chr14:101,064,495...101,064,578

G

microRNA 542

increases expression

2,5-hexanedione results in increased expression of MIR542 mRNA

NCBI chr X:134,541,341...134,541,437
Ensembl chr X:134,541,341...134,541,437

G

microRNA 551b

decreases expression

2,5-hexanedione results in decreased expression of MIR551B mRNA

NCBI chr 3:168,551,854...168,551,949
Ensembl chr 3:168,551,854...168,551,949

G

microRNA 582

increases expression

2,5-hexanedione results in increased expression of MIR582 mRNA

NCBI chr 5:59,703,606...59,703,703
Ensembl chr 5:59,703,606...59,703,703

G

microRNA 652

decreases expression

2,5-hexanedione results in decreased expression of MIR652 mRNA

NCBI chr X:110,055,329...110,055,426
Ensembl chr X:110,055,329...110,055,426

G

microRNA 653

decreases expression

2,5-hexanedione results in decreased expression of MIR653 mRNA

NCBI chr 7:93,482,760...93,482,855
Ensembl chr 7:93,482,760...93,482,855

G

microRNA 665

increases expression

2,5-hexanedione results in increased expression of MIR665 mRNA

NCBI chr14:100,875,033...100,875,104
Ensembl chr14:100,875,033...100,875,104

G

microRNA 675

increases expression

2,5-hexanedione results in increased expression of MIR675 mRNA

NCBI chr11:1,996,759...1,996,831
Ensembl chr11:1,996,759...1,996,831

G

microRNA 7-2

increases expression

2,5-hexanedione results in increased expression of MIR8 mRNA

NCBI chr15:88,611,825...88,611,934
Ensembl chr15:88,611,825...88,611,934

G

microRNA 760

decreases expression

2,5-hexanedione results in decreased expression of MIR760 mRNA

NCBI chr 1:93,846,832...93,846,911
Ensembl chr 1:93,846,832...93,846,911

G

microRNA 770

increases expression

2,5-hexanedione results in increased expression of MIR770 mRNA

NCBI chr14:100,852,390...100,852,487
Ensembl chr14:100,852,390...100,852,487

G

microRNA 873

increases expression

2,5-hexanedione results in increased expression of MIR873 mRNA

NCBI chr 9:28,888,879...28,888,955
Ensembl chr 9:28,888,879...28,888,955

G

microRNA 877

increases expression

2,5-hexanedione results in increased expression of MIR877 mRNA

NCBI chr 6:30,584,332...30,584,417
Ensembl chr 6:30,584,332...30,584,417

G

microRNA let-7b

increases expression

2,5-hexanedione results in increased expression of MIRLET7B mRNA

NCBI chr22:46,113,686...46,113,768
Ensembl chr22:46,113,686...46,113,768

G

microRNA let-7f-1

decreases expression

2,5-hexanedione results in decreased expression of MIRLET7F1 mRNA

NCBI chr 9:94,176,347...94,176,433
Ensembl chr 9:94,176,347...94,176,433

G

microRNA let-7i

increases expression

2,5-hexanedione results in increased expression of MIRLET7I mRNA

NCBI chr12:62,603,686...62,603,769
Ensembl chr12:62,603,686...62,603,769

G

mannose receptor C-type 1

decreases expression
multiple interactions

2,5-hexanedione results in decreased expression of MRC1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MRC1 mRNA]

PMID:32522579 PMID:32860822

NCBI chr10:17,809,348...17,911,164
Ensembl chr10:17,809,348...17,911,164

G

myotubularin 1

increases expression

2,5-hexanedione results in increased expression of MTM1 mRNA

NCBI chr X:150,562,653...150,673,143
Ensembl chr X:150,568,417...150,673,143

G

NSF attachment protein alpha

decreases expression

2,5-hexanedione results in decreased expression of NAPA protein

NCBI chr19:47,484,530...47,515,063
Ensembl chr19:47,487,637...47,515,091

G

NADH:ubiquinone oxidoreductase subunit A10

increases expression
decreases expression

2,5-hexanedione results in increased expression of NDUFA10 protein
2,5-hexanedione results in decreased expression of NDUFA10 protein

NCBI chr 2:239,892,442...240,025,342
Ensembl chr 2:239,892,450...240,025,743

G

neurofilament heavy chain

decreases expression

2,5-hexanedione results in decreased expression of NEFH protein

NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390

G

neurofilament light chain

decreases expression
multiple interactions

2,5-hexanedione results in decreased expression of NEFL protein
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of NEFL protein]

PMID:19033394 PMID:32522579 PMID:32860822

NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,956,721

G

neurofilament medium chain

decreases expression

2,5-hexanedione results in decreased expression of NEFM protein

NCBI chr 8:24,913,761...24,919,093
Ensembl chr 8:24,913,758...24,919,098

G

NLR family pyrin domain containing 3

increases expression
multiple interactions

2,5-hexanedione results in increased expression of NLRP3 mRNA; 2,5-hexanedione results in increased expression of NLRP3 protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NLRP3 protein]

PMID:32522579 PMID:32860822

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108

G

nitric oxide synthase 2

multiple interactions
increases expression

Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NOS2 mRNA]

PMID:32522579 PMID:32860822

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

decreases expression

2,5-hexanedione results in decreased expression of NSF protein

NCBI chr17:46,590,669...46,757,464
Ensembl chr17:46,590,669...46,757,679

G

nuclear protein 2, transcriptional regulator

increases expression

2,5-hexanedione results in increased expression of NUPR2 mRNA

NCBI chr 7:56,114,681...56,116,417
Ensembl chr 7:56,114,681...56,116,417

G

protein disulfide isomerase family A member 3

decreases expression

2,5-hexanedione results in decreased expression of PDIA3 protein

NCBI chr15:43,746,438...43,773,278
Ensembl chr15:43,746,394...43,773,279

G

PDZ and LIM domain 3

decreases expression

2,5-hexanedione results in decreased expression of PDLIM3 protein

NCBI chr 4:185,500,660...185,535,507
Ensembl chr 4:185,500,660...185,535,507

G

phosphoglycerate mutase 1

increases expression

2,5-hexanedione results in increased expression of PGAM1 protein

NCBI chr10:97,426,191...97,433,444
Ensembl chr10:97,426,191...97,433,444

G

phosphoethanolamine/phosphocholine phosphatase 1

increases expression

2,5-hexanedione results in increased expression of PHOSPHO1 mRNA

NCBI chr17:49,223,366...49,230,787
Ensembl chr17:49,223,366...49,230,787

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

decreases expression

2,5-hexanedione results in decreased expression of PIK3CA mRNA

NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093

G

phosphoinositide-3-kinase regulatory subunit 1

decreases expression

2,5-hexanedione results in decreased expression of PIK3R1 protein

NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821

G

Pim-1 proto-oncogene, serine/threonine kinase

increases expression

2,5-hexanedione results in increased expression of PIM1 mRNA

NCBI chr 6:37,170,152...37,175,428
Ensembl chr 6:37,170,152...37,175,428

G

pyruvate kinase M1/2

increases expression

2,5-hexanedione results in increased expression of PKM protein

NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819

G

POU class 2 homeobox 1

increases expression

2,5-hexanedione results in increased expression of POU2F1 mRNA

NCBI chr 1:167,220,885...167,427,345
Ensembl chr 1:167,220,876...167,427,345

G

PRKCSH beta subunit of glucosidase II

decreases expression

2,5-hexanedione results in decreased expression of PRKCSH protein

NCBI chr19:11,435,635...11,450,968
Ensembl chr19:11,435,284...11,450,968

G

prostaglandin D2 synthase

increases expression

2,5-hexanedione results in increased expression of PTGDS mRNA

PMID:22952946 PMID:27466211

NCBI chr 9:136,977,504...136,981,742
Ensembl chr 9:136,975,092...136,981,742

G

PYD and CARD domain containing

increases expression

2,5-hexanedione results in increased expression of PYCARD mRNA; 2,5-hexanedione results in increased expression of PYCARD protein

NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450

G

glycogen phosphorylase B

decreases expression

2,5-hexanedione results in decreased expression of PYGB protein

NCBI chr20:25,248,085...25,298,012
Ensembl chr20:25,248,085...25,298,012

G

glycogen phosphorylase, muscle associated

decreases expression

2,5-hexanedione results in decreased expression of PYGM protein

NCBI chr11:64,746,389...64,760,715
Ensembl chr11:64,746,389...64,759,974

G

Ral GTPase activating protein catalytic subunit alpha 2

increases expression

2,5-hexanedione results in increased expression of RALGAPA2 mRNA

NCBI chr20:20,389,530...20,712,644
Ensembl chr20:20,389,530...20,712,644

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

2,5-hexanedione results in decreased expression of and affects the localization of RELA protein

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

rhotekin 2

increases expression

2,5-hexanedione results in increased expression of RTKN2 mRNA

NCBI chr10:62,183,900...62,268,844
Ensembl chr10:62,183,035...62,268,844

G

S100 calcium binding protein Z

increases expression

2,5-hexanedione results in increased expression of S100Z mRNA

NCBI chr 5:76,850,014...76,952,953
Ensembl chr 5:76,850,001...76,921,650

G

sodium channel and clathrin linker 1

increases expression

2,5-hexanedione results in increased expression of SCLT1 mRNA

NCBI chr 4:128,873,241...129,093,539
Ensembl chr 4:128,864,921...129,093,600

G

septin 8

decreases expression

2,5-hexanedione results in decreased expression of SEPTIN8 protein

NCBI chr 5:132,750,819...132,780,083
Ensembl chr 5:132,750,819...132,807,241

G

SH2 domain containing 4A

decreases expression

2,5-hexanedione results in decreased expression of SH2D4A mRNA

NCBI chr 8:19,313,693...19,396,218
Ensembl chr 8:19,313,693...19,396,218

G

SH3 and multiple ankyrin repeat domains 3

multiple interactions

[carbendazim co-treated with 2,5-hexanedione] affects the expression of SHANK3 mRNA

NCBI chr22:50,672,823...50,733,212
Ensembl chr22:50,674,415...50,733,212

G

SIL1 nucleotide exchange factor

increases expression

2,5-hexanedione results in increased expression of SIL1 mRNA

NCBI chr 5:138,946,724...139,198,368
Ensembl chr 5:138,946,724...139,293,557

G

solute carrier family 10 member 7

increases expression

2,5-hexanedione results in increased expression of SLC10A7 mRNA

NCBI chr 4:146,253,981...146,521,940
Ensembl chr 4:146,253,975...146,522,372

G

SAFB like transcription modulator

increases expression

2,5-hexanedione results in increased expression of SLTM mRNA

NCBI chr15:58,879,050...58,933,679
Ensembl chr15:58,879,050...58,933,679

G

superoxide dismutase 3

increases expression

2,5-hexanedione results in increased expression of SOD3 mRNA

PMID:22952946 PMID:27466211

NCBI chr 4:24,795,573...24,800,842
Ensembl chr 4:24,789,912...24,800,842

G

signal peptide peptidase like 3

increases expression

2,5-hexanedione results in increased expression of SPPL3 mRNA

NCBI chr12:120,762,510...120,904,358
Ensembl chr12:120,762,510...120,904,358

G

spectrin alpha, non-erythrocytic 1

decreases expression

2,5-hexanedione results in decreased expression of SPTAN1 protein

NCBI chr 9:128,552,587...128,633,662
Ensembl chr 9:128,552,558...128,633,662

G

stathmin 1

decreases expression

2,5-hexanedione results in decreased expression of STMN1 mRNA

NCBI chr 1:25,884,179...25,906,880
Ensembl chr 1:25,884,181...25,906,991

G

spermatid perinuclear RNA binding protein

increases expression

2,5-hexanedione results in increased expression of STRBP mRNA

NCBI chr 9:123,109,494...123,268,586
Ensembl chr 9:123,109,500...123,268,586

G

serine/threonine/tyrosine interacting like 1

increases expression

2,5-hexanedione results in increased expression of STYXL1 mRNA

NCBI chr 7:75,996,337...76,048,000
Ensembl chr 7:75,996,338...76,048,004

G

Tax1 binding protein 1

increases expression

2,5-hexanedione results in increased expression of TAX1BP1 mRNA

NCBI chr 7:27,739,373...27,829,767
Ensembl chr 7:27,739,331...27,844,564

G

TBC1 domain family member 5

increases expression

2,5-hexanedione results in increased expression of TBC1D5 mRNA

NCBI chr 3:17,157,162...17,742,631
Ensembl chr 3:17,157,162...18,444,817

G

transmembrane protein 192

increases expression

2,5-hexanedione results in increased expression of TMEM192 mRNA

NCBI chr 4:165,070,608...165,112,860
Ensembl chr 4:165,070,608...165,208,549

G

tumor necrosis factor

multiple interactions
increases expression

Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of TNF mRNA]

PMID:32522579 PMID:32860822

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

triosephosphate isomerase 1

increases expression

2,5-hexanedione results in increased expression of TPI1 mRNA; 2,5-hexanedione results in increased expression of TPI1 protein

PMID:19033394 PMID:22952946

NCBI chr12:6,867,420...6,870,948
Ensembl chr12:6,867,119...6,870,948

G

ubiquitin like modifier activating enzyme 1

increases expression

2,5-hexanedione results in increased expression of UBA1 protein

NCBI chr X:47,190,847...47,215,128
Ensembl chr X:47,190,861...47,215,128

G

ubinuclein 2

increases expression

2,5-hexanedione results in increased expression of UBN2 mRNA

NCBI chr 7:139,231,237...139,330,428
Ensembl chr 7:139,230,356...139,308,236

G

ubiquinol-cytochrome c reductase core protein 2

decreases expression

2,5-hexanedione results in decreased expression of UQCRC2 mRNA

NCBI chr16:21,953,361...21,983,660
Ensembl chr16:21,953,288...21,983,660

G

vimentin

multiple interactions

2,5-hexanedione promotes the reaction [VIM protein binds to VIM protein]

NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593

G

X-linked inhibitor of apoptosis

decreases expression

2,5-hexanedione results in decreased expression of XIAP mRNA

NCBI chr X:123,859,708...123,913,972
Ensembl chr X:123,859,712...123,913,972

G

zinc finger protein 169

decreases expression

2,5-hexanedione results in decreased expression of ZFP169 protein

NCBI chr 9:94,259,298...94,301,829
Ensembl chr 9:94,259,298...94,301,829

G

zinc finger protein 407

increases expression

2,5-hexanedione results in increased expression of ZFP407 mRNA

NCBI chr18:74,597,870...75,065,671
Ensembl chr18:74,597,870...75,065,671

4,6-dioxoheptanoic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

5'-aminolevulinate synthase 1

multiple interactions
increases expression

NFE2L2 gene mutant form inhibits the reaction [succinylacetone results in increased expression of ALAS1 mRNA]
succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]

PMID:21659532 PMID:22859313

NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327

G

cytochrome P450 family 2 subfamily A member 6

multiple interactions
increases expression

NFE2L2 gene mutant form affects the reaction [succinylacetone results in increased expression of CYP2A5 mRNA]

NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447

G

heme oxygenase 1

increases expression

succinylacetone results in increased expression of HMOX1 mRNA

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

NFE2 like bZIP transcription factor 2

multiple interactions

NFE2L2 gene mutant form affects the reaction [succinylacetone results in increased expression of CYP2A5 mRNA]; NFE2L2 gene mutant form inhibits the reaction [succinylacetone results in increased expression of ALAS1 mRNA]

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

PPARG coactivator 1 alpha

increases expression

succinylacetone results in increased expression of PPARGC1A mRNA

NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089

acetylacetonate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

metallothionein 1X

increases expression

acetyl acetonate analog results in increased expression of MT1 mRNA

NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196

benzil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

dehydrogenase/reductase 3

increases metabolic processing

DHRS3 protein results in increased metabolism of benzil

NCBI chr 1:12,567,910...12,618,210
Ensembl chr 1:12,567,910...12,618,210

G

dehydrogenase/reductase 7

increases reduction

DHRS7 protein results in increased reduction of benzil

NCBI chr14:60,144,119...60,169,889
Ensembl chr14:60,144,119...60,169,856

G

epoxide hydrolase 2

decreases activity

benzil results in decreased activity of EPHX2 protein

NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564

bisdemethoxycurcumin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

decreases activity

bisdemethoxycurcumin results in decreased activity of ABCC1 protein; curcumin III results in decreased activity of ABCC1 protein

PMID:15885658 PMID:16021489

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

G

ATP binding cassette subfamily C member 2

decreases activity

bisdemethoxycurcumin results in decreased activity of ABCC2 protein

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

AKT serine/threonine kinase 1

increases phosphorylation
decreases expression
multiple interactions

bisdemethoxycurcumin results in increased phosphorylation of AKT1 protein
bisdemethoxycurcumin results in decreased expression of AKT1 protein modified form
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]
AKT1 protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]

PMID:17535857 PMID:35735092 PMID:35752269

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

amyloid beta precursor protein

multiple interactions

[bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of MGAT3 mRNA; [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR2 mRNA; [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR3 mRNA; [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR4 mRNA; [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of VDR mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of MGAT3 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR2 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR3 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR4 mRNA; bisdemethoxycurcumin inhibits the reaction [APP protein binds to APP protein]

PMID:19715544 PMID:22029407

NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128

G

CD36 molecule (CD36 blood group)

increases expression
multiple interactions

bisdemethoxycurcumin results in increased expression of CD36 mRNA
bisdemethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]

NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277

G

epidermal growth factor receptor

decreases expression

bisdemethoxycurcumin results in decreased expression of EGFR protein modified form

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

erb-b2 receptor tyrosine kinase 2

increases response to substance
decreases expression

ERBB2 protein results in increased susceptibility to bisdemethoxycurcumin
bisdemethoxycurcumin results in decreased expression of ERBB2 protein

NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426

G

glutamate-cysteine ligase modifier subunit

increases expression

bisdemethoxycurcumin results in increased expression of GCLM mRNA; bisdemethoxycurcumin results in increased expression of GCLM protein

PMID:17535857 PMID:19188863

NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456

G

growth factor receptor bound protein 2

decreases expression

bisdemethoxycurcumin results in decreased expression of GRB2 protein

NCBI chr17:75,318,076...75,405,678
Ensembl chr17:75,318,076...75,405,709

G

heme oxygenase 1

increases expression
multiple interactions

bisdemethoxycurcumin results in increased expression of HMOX1 mRNA; bisdemethoxycurcumin results in increased expression of HMOX1 protein
[demethoxycurcumin co-treated with bisdemethoxycurcumin] results in increased expression of HMOX1 mRNA; AKT1 protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; KEAP1 protein inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; PRKCD protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 protein]

PMID:17535857 PMID:19188863 PMID:23386263

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

kinase insert domain receptor

multiple interactions

[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]

NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595

G

kelch like ECH associated protein 1

multiple interactions

KEAP1 protein inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]

NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558

G

mitogen-activated protein kinase 1

increases phosphorylation
decreases expression
multiple interactions

bisdemethoxycurcumin results in increased phosphorylation of MAPK1 protein
bisdemethoxycurcumin results in decreased expression of MAPK1 protein modified form
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]

PMID:17535857 PMID:35735092 PMID:35752269

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

increases phosphorylation
decreases expression
multiple interactions

bisdemethoxycurcumin results in increased phosphorylation of MAPK3 protein
bisdemethoxycurcumin results in decreased expression of MAPK3 protein modified form
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]

PMID:17535857 PMID:35735092 PMID:35752269

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

multiple interactions
increases expression

[bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of MGAT3 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of MGAT3 mRNA
bisdemethoxycurcumin results in increased expression of MGAT3 mRNA

PMID:19090986 PMID:22029407

NCBI chr22:39,457,012...39,492,194
Ensembl chr22:39,457,012...39,492,194

G

matrix metallopeptidase 14

decreases expression

bisdemethoxycurcumin results in decreased expression of MMP14 protein

NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,041

G

matrix metallopeptidase 2

multiple interactions
decreases expression

bisdemethoxycurcumin results in decreased secretion of and results in decreased activity of MMP2 protein modified form
bisdemethoxycurcumin results in decreased expression of MMP2 protein

PMID:18495463 PMID:35735092

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 9

multiple interactions
decreases expression

bisdemethoxycurcumin results in decreased secretion of and results in decreased activity of MMP9 protein
bisdemethoxycurcumin results in decreased expression of MMP9 protein

PMID:18495463 PMID:35735092

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

macrophage scavenger receptor 1

multiple interactions

bisdemethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]

NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490

G

NFE2 like bZIP transcription factor 2

affects localization
multiple interactions

bisdemethoxycurcumin affects the localization of NFE2L2 protein
[demethoxycurcumin co-treated with bisdemethoxycurcumin] affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

NFKB inhibitor alpha

multiple interactions

bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

nitric oxide synthase 2

multiple interactions

bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:18449507 PMID:18481332 PMID:18838107 PMID:19188055

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

NAD(P)H quinone dehydrogenase 1

increases expression

bisdemethoxycurcumin results in increased expression of NQO1 mRNA; bisdemethoxycurcumin results in increased expression of NQO1 protein

PMID:17535857 PMID:19188863

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

3-phosphoinositide dependent protein kinase 1

decreases expression

bisdemethoxycurcumin results in decreased expression of PDPK1 protein modified form

NCBI chr16:2,538,021...2,603,188
Ensembl chr16:2,537,979...2,603,188

G

plasminogen activator, urokinase

decreases secretion

bisdemethoxycurcumin results in decreased secretion of PLAU protein

NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496

G

peroxisome proliferator activated receptor gamma

affects binding

bisdemethoxycurcumin binds to PPARG protein

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

protein kinase C delta

multiple interactions

PRKCD protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]

NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717

G

prostaglandin-endoperoxide synthase 2

multiple interactions

bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases expression

bisdemethoxycurcumin results in decreased expression of RAF1 protein modified form

NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

bisdemethoxycurcumin results in decreased expression of SOS1 protein

NCBI chr 2:38,981,549...39,124,868
Ensembl chr 2:38,962,206...39,124,345

G

TIMP metallopeptidase inhibitor 1

decreases expression

bisdemethoxycurcumin results in decreased expression of TIMP1 protein

NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789

G

TIMP metallopeptidase inhibitor 2

decreases expression

bisdemethoxycurcumin results in decreased expression of TIMP2 protein

NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387

G

toll like receptor 2

multiple interactions

[bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR2 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR2 mRNA

NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,070...153,706,260

G

toll like receptor 3

multiple interactions

[bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR3 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR3 mRNA

NCBI chr 4:186,069,156...186,088,073
Ensembl chr 4:186,068,911...186,088,073

G

toll like receptor 4

multiple interactions

[bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR4 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR4 mRNA

NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735

G

tumor necrosis factor

multiple interactions

bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

vitamin D receptor

multiple interactions

[bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of VDR mRNA

NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048

G

vascular endothelial growth factor A

multiple interactions

[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

G

WT1 transcription factor

decreases expression

bisdemethoxycurcumin results in decreased expression of WT1 mRNA; bisdemethoxycurcumin results in decreased expression of WT1 protein

NCBI chr11:32,387,775...32,435,539
Ensembl chr11:32,387,775...32,435,564

butane-2,3-dione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1 member B

increases reduction
multiple interactions

AKR1B1 protein results in increased reduction of Diacetyl
[AKR1B1 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin

NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284

G

aldo-keto reductase family 1 member B10

increases reduction
multiple interactions

AKR1B10 protein results in increased reduction of Diacetyl
[AKR1B10 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin

NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412

G

albumin

affects binding

Diacetyl binds to ALB protein

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

aldehyde dehydrogenase 1 family member A3

increases expression

Diacetyl results in increased expression of ALDH1A3 mRNA

NCBI chr15:100,879,831...100,916,626
Ensembl chr15:100,877,714...100,916,626

G

aldehyde dehydrogenase 7 family member A1

decreases expression

Diacetyl results in decreased expression of ALDH7A1 protein

NCBI chr 5:126,541,841...126,595,219
Ensembl chr 5:126,531,200...126,595,362

G

amphiregulin

increases secretion

Diacetyl results in increased secretion of AREG protein

PMID:30851105 PMID:31381966

NCBI chr 4:74,445,136...74,455,005
Ensembl chr 4:74,445,136...74,455,005

G

beta-1,3-glucuronyltransferase 3

decreases activity
multiple interactions

Diacetyl results in decreased activity of B3GAT3 protein
Uridine Diphosphate Glucuronic Acid inhibits the reaction [Diacetyl results in decreased activity of B3GAT3 protein]

NCBI chr11:62,615,296...62,621,986
Ensembl chr11:62,615,296...62,622,154

G

BCL2 apoptosis regulator

decreases expression

Diacetyl results in decreased expression of BCL2 mRNA

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

caspase 3

increases expression

Diacetyl results in increased expression of CASP3 mRNA; Diacetyl results in increased expression of CASP3 protein

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

catalase

decreases expression

Diacetyl results in decreased expression of CAT protein

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

coiled-coil and C2 domain containing 2A

decreases expression

Diacetyl results in decreased expression of CC2D2A mRNA

NCBI chr 4:15,469,865...15,601,557
Ensembl chr 4:15,469,865...15,601,552

G

cyclin B1

decreases expression

Diacetyl results in decreased expression of CCNB1 mRNA

NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245

G

cell division cycle 20B

decreases expression

Diacetyl results in decreased expression of CDC20B mRNA

NCBI chr 5:55,112,971...55,173,177
Ensembl chr 5:55,112,971...55,173,177

G

cyclin dependent kinase 1

decreases expression

Diacetyl results in decreased expression of CDK1 mRNA

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

cilia and flagella associated protein 221

decreases expression

Diacetyl results in decreased expression of CFAP221 mRNA

NCBI chr 2:119,544,449...119,660,323
Ensembl chr 2:119,544,432...119,662,251

G

cilia and flagella associated protein 70

decreases expression

Diacetyl results in decreased expression of CFAP70 mRNA

NCBI chr10:73,253,762...73,362,979
Ensembl chr10:73,253,762...73,358,864

G

C-X-C motif chemokine ligand 1

increases expression
multiple interactions

Diacetyl results in increased expression of CXCL1 mRNA
Diacetyl results in increased expression of and results in increased secretion of CXCL1 protein

PMID:25145656 PMID:30851105

NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308

G

C-X-C motif chemokine ligand 8

affects expression
multiple interactions

Diacetyl analog affects the expression of CXCL8 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Diacetyl results in increased expression of and results in increased secretion of CXCL8 protein]; Diacetyl results in increased expression of and results in increased secretion of CXCL8 protein; N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [Diacetyl results in increased expression of and results in increased secretion of CXCL8 protein]; RTKI cpd inhibits the reaction [Diacetyl results in increased expression of and results in increased secretion of CXCL8 protein]

PMID:20200221 PMID:30851105

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

dicarbonyl and L-xylulose reductase

multiple interactions

1,2-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; 1,4-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; 9,10-phenanthrenequinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; [[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin; [DCXR protein co-treated with NAD] results in increased reduction of Diacetyl; [DCXR protein co-treated with NADP] results in increased reduction of Diacetyl; Butyric Acid inhibits the reaction [[DCXR protein co-treated with NADP] results in increased reduction of Diacetyl]; Diacetyl inhibits the reaction [[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides]; Heptanoic Acids inhibits the reaction [[DCXR protein co-treated with NADP] results in increased reduction of Diacetyl]; hexanoic acid inhibits the reaction [[DCXR protein co-treated with NADP] results in increased reduction of Diacetyl]; Pentanoic Acids inhibits the reaction [[DCXR protein co-treated with NADP] results in increased reduction of Diacetyl]; Vitamin K 3 inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]

NCBI chr17:82,035,858...82,037,697
Ensembl chr17:82,035,136...82,037,709

G

dehydrogenase/reductase 9

increases expression

Diacetyl results in increased expression of DHRS9 mRNA

NCBI chr 2:169,067,077...169,096,167
Ensembl chr 2:169,064,789...169,096,167

G

dynein axonemal assembly factor 1

decreases expression

Diacetyl results in decreased expression of DNAAF1 mRNA

NCBI chr16:84,145,308...84,177,920
Ensembl chr16:84,145,287...84,178,767

G

dynein axonemal heavy chain 12

decreases expression

Diacetyl results in decreased expression of DNAH12 mRNA

NCBI chr 3:57,293,700...57,556,034
Ensembl chr 3:57,293,699...57,544,344

G

dynein axonemal heavy chain 3

decreases expression

Diacetyl results in decreased expression of DNAH3 mRNA

NCBI chr16:20,933,111...21,159,459
Ensembl chr16:20,933,111...21,159,441

G

dynein axonemal heavy chain 6

decreases expression

Diacetyl results in decreased expression of DNAH6 mRNA

NCBI chr 2:84,459,572...84,819,589
Ensembl chr 2:84,516,455...84,819,589

G

dynein axonemal intermediate chain 1

decreases expression

Diacetyl results in decreased expression of DNAI1 mRNA

NCBI chr 9:34,458,805...34,520,984
Ensembl chr 9:34,457,414...34,520,988

G

desmoplakin

decreases expression

Diacetyl results in decreased expression of DSP protein

NCBI chr 6:7,541,671...7,586,714
Ensembl chr 6:7,541,338...7,586,714

G

epidermal growth factor receptor

increases phosphorylation
multiple interactions

Diacetyl results in increased phosphorylation of EGFR protein
N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [Diacetyl results in increased phosphorylation of EGFR protein]

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

glutamate-cysteine ligase catalytic subunit

increases expression

Diacetyl results in increased expression of GCLC mRNA

NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970

G

glutathione-disulfide reductase

decreases expression

Diacetyl results in decreased expression of GSR protein

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

glutathione S-transferase alpha 1

increases expression

Diacetyl results in increased expression of GSTA1 mRNA

NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860

G

heparin binding EGF like growth factor

increases secretion

Diacetyl results in increased secretion of HBEGF protein

NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603

G

heme oxygenase 1

increases expression

Diacetyl results in increased expression of HMOX1 mRNA

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

interleukin 10

decreases expression

Diacetyl results in decreased expression of IL10 protein

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 13

increases expression

Diacetyl results in increased expression of IL13 protein

NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110

G

interleukin 1 beta

increases expression

Diacetyl results in increased expression of IL1B protein

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 2

increases expression

Diacetyl results in increased expression of IL2 protein

NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725

G

interleukin 4

increases expression

Diacetyl results in increased expression of IL4 protein

NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678

G

interleukin 6

affects expression
increases expression
decreases expression

Diacetyl analog affects the expression of IL6 mRNA
Diacetyl results in increased expression of IL6 protein
Diacetyl results in decreased expression of IL6 mRNA
Diacetyl results in increased expression of IL6 mRNA

PMID:20200221 PMID:25145656 PMID:31381966 PMID:37399938

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

integrin subunit alpha 6

decreases expression

Diacetyl results in decreased expression of ITGA6 protein

NCBI chr 2:172,427,336...172,506,459
Ensembl chr 2:172,427,354...172,506,459

G

integrin subunit alpha V

decreases expression

Diacetyl results in decreased expression of ITGAV protein

NCBI chr 2:186,590,056...186,680,901
Ensembl chr 2:186,590,010...186,680,901

G

integrin subunit beta 4

decreases expression

Diacetyl results in decreased expression of ITGB4 protein

NCBI chr17:75,721,459...75,757,818
Ensembl chr17:75,721,328...75,757,818

G

keratin 19

decreases expression

Diacetyl results in decreased expression of KRT19 protein

NCBI chr17:41,523,617...41,528,308
Ensembl chr17:41,523,617...41,528,308

G

keratin 5

multiple interactions

benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [Diacetyl affects the expression of and affects the ubiquitination of KRT5 protein]; Diacetyl affects the expression of and affects the ubiquitination of KRT5 protein

NCBI chr12:52,514,575...52,520,394
Ensembl chr12:52,514,575...52,520,530

G

mono-ADP ribosylhydrolase 2

decreases expression

Diacetyl results in decreased expression of MACROD2 mRNA

NCBI chr20:13,995,516...16,053,197
Ensembl chr20:13,995,369...16,053,197

G

mitogen-activated protein kinase 1

increases phosphorylation
multiple interactions

Diacetyl results in increased phosphorylation of MAPK1 protein
RTKI cpd inhibits the reaction [Diacetyl results in increased phosphorylation of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

increases phosphorylation
multiple interactions

Diacetyl results in increased phosphorylation of MAPK3 protein
RTKI cpd inhibits the reaction [Diacetyl results in increased phosphorylation of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

MIR205 host gene

decreases expression

Diacetyl results in decreased expression of MIR205HG mRNA

NCBI chr 1:209,428,820...209,432,549
Ensembl chr 1:209,428,817...209,432,848

G

matrix metallopeptidase 9

increases expression
increases secretion

Diacetyl results in increased expression of MMP9 mRNA
Diacetyl results in increased secretion of MMP9 protein

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

NFE2 like bZIP transcription factor 2

affects localization

Diacetyl affects the localization of NFE2L2 protein

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nuclear factor kappa B subunit 1

increases expression

Diacetyl results in increased expression of NFKB1 mRNA

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

nicotinamide nucleotide transhydrogenase

decreases expression

Diacetyl results in decreased expression of NNT protein

NCBI chr 5:43,602,675...43,707,396
Ensembl chr 5:43,602,692...43,707,405

G

3'-phosphoadenosine 5'-phosphosulfate synthase 2

decreases expression

Diacetyl results in decreased expression of PAPSS2 mRNA

NCBI chr10:87,659,878...87,747,705
Ensembl chr10:87,659,613...87,747,705

G

plakophilin 1

decreases expression

Diacetyl results in decreased expression of PKP1 protein

NCBI chr 1:201,283,506...201,332,989
Ensembl chr 1:201,283,452...201,332,993

G

prominin 1

decreases expression

Diacetyl results in decreased expression of PROM1 mRNA

NCBI chr 4:15,968,228...16,084,023
Ensembl chr 4:15,963,076...16,084,378

G

proteasome 20S subunit beta 5

increases expression

Diacetyl results in increased expression of PSMB5 protein

NCBI chr14:23,025,851...23,035,220
Ensembl chr14:23,016,543...23,035,230

G

proteasome 26S subunit, ATPase 1

increases expression

Diacetyl results in increased expression of PSMC1 protein

NCBI chr14:90,256,553...90,275,429
Ensembl chr14:90,256,527...90,275,429

G

prostaglandin E synthase 2

increases expression

Diacetyl results in increased expression of PTGES2 mRNA

NCBI chr 9:128,120,693...128,128,440
Ensembl chr 9:128,120,693...128,128,462

G

prostaglandin-endoperoxide synthase 2

decreases expression

Diacetyl results in decreased expression of PTGS2 mRNA

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

parathyroid hormone like hormone

decreases expression

Diacetyl results in decreased expression of PTHLH mRNA

NCBI chr12:27,958,084...27,972,733
Ensembl chr12:27,958,084...27,972,733

G

receptor interacting serine/threonine kinase 3

increases expression

Diacetyl results in increased expression of RIPK3 mRNA; Diacetyl results in increased expression of RIPK3 protein

NCBI chr14:24,336,025...24,339,991
Ensembl chr14:24,336,025...24,340,022

G

secretoglobin family 1A member 1

decreases expression

Diacetyl results in decreased expression of SCGB1A1 protein

NCBI chr11:62,419,033...62,423,195
Ensembl chr11:62,405,103...62,423,195

G

secretory leukocyte peptidase inhibitor

affects expression
increases secretion

Diacetyl affects the expression of SLPI mRNA
Diacetyl results in increased secretion of SLPI protein

NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564

G

sortilin related VPS10 domain containing receptor 2

decreases expression

Diacetyl results in decreased expression of SORCS2 mRNA

NCBI chr 4:7,192,538...7,742,827
Ensembl chr 4:7,192,538...7,742,827

G

sperm associated antigen 17

decreases expression

Diacetyl results in decreased expression of SPAG17 mRNA

NCBI chr 1:117,953,590...118,185,228
Ensembl chr 1:117,953,590...118,185,228

G

sequestosome 1

increases expression

Diacetyl results in increased expression of SQSTM1 protein

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

Tax1 binding protein 3

increases expression

Diacetyl results in increased expression of TAX1BP3 mRNA

NCBI chr17:3,662,895...3,668,578
Ensembl chr17:3,662,895...3,668,679

G

tektin 1

decreases expression

Diacetyl results in decreased expression of TEKT1 mRNA

NCBI chr17:6,797,993...6,831,729
Ensembl chr17:6,789,133...6,831,761

G

transforming growth factor alpha

increases secretion

Diacetyl results in increased secretion of TGFA protein

NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193

G

tenascin C

increases expression

Diacetyl results in increased expression of TNC protein

NCBI chr 9:115,019,575...115,118,157
Ensembl chr 9:115,019,575...115,118,207

G

tumor necrosis factor

increases expression

Diacetyl results in increased expression of TNF mRNA
Diacetyl results in increased expression of TNF protein

PMID:31381966 PMID:37399938

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

tumor protein p53

increases expression

Diacetyl results in increased expression of TRP53 mRNA

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

tumor protein p63

affects expression

Diacetyl affects the expression of TP63 protein alternative form

NCBI chr 3:189,596,746...189,897,276
Ensembl chr 3:189,631,389...189,897,276

G

thyroid hormone receptor interactor 12

increases expression

Diacetyl results in increased expression of TRIP12 protein

NCBI chr 2:229,763,837...229,923,186
Ensembl chr 2:229,763,837...229,923,239

G

ubiquitin C

increases expression

Diacetyl results in increased expression of UBC protein

NCBI chr12:124,911,646...124,914,650
Ensembl chr12:124,911,604...124,917,368

G

ubiquitin conjugating enzyme E2 L3

increases expression

Diacetyl results in increased expression of UBE2L3 protein

NCBI chr22:21,549,447...21,624,034
Ensembl chr22:21,549,447...21,624,034

G

ubiquitin C-terminal hydrolase L5

increases expression

Diacetyl results in increased expression of UCHL5 protein

NCBI chr 1:193,012,254...193,060,076
Ensembl chr 1:193,012,250...193,060,080

G

ubiquitin specific peptidase 14

increases expression

Diacetyl results in increased expression of USP14 protein

NCBI chr18:158,557...214,629
Ensembl chr18:158,383...214,629

curcumin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha 1,4-galactosyltransferase (P1PK blood group)

multiple interactions

Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA]

NCBI chr22:42,692,121...42,721,301
Ensembl chr22:42,692,121...42,721,298

G

alanyl-tRNA synthetase 1

decreases expression

Curcumin results in decreased expression of AARS1 mRNA

NCBI chr16:70,252,298...70,289,506
Ensembl chr16:70,251,983...70,289,707

G

ATP binding cassette subfamily A member 1

multiple interactions

Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]

NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155

G

ATP binding cassette subfamily B member 1

decreases expression
decreases response to substance
affects response to substance
multiple interactions

Curcumin analog results in decreased expression of ABCB1 protein; Curcumin results in decreased expression of ABCB1 mRNA; Curcumin results in decreased expression of ABCB1B mRNA
ABCB1 protein results in decreased susceptibility to Curcumin
ABCB1 affects the susceptibility to Curcumin
[Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Calcitriol promotes the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ABCB1 mRNA]
[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; [Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein; [sulfinosine co-treated with Curcumin] results in decreased expression of ABCB1 mRNA; Calcitriol inhibits the reaction [[Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin results in decreased expression of and results in decreased activity of ABCB1 protein

PMID:15476675 PMID:17121181 PMID:18200517 PMID:18385293 PMID:18414057 More...

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

decreases activity
decreases expression

Curcumin results in decreased activity of ABCC1 protein
Curcumin analog results in decreased expression of ABCC1 mRNA

PMID:15885658 PMID:16021489 PMID:26409325

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

G

ATP binding cassette subfamily C member 2

decreases activity
multiple interactions

Curcumin results in decreased activity of ABCC2 protein
[Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 protein

PMID:15885658 PMID:35243748

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ATP binding cassette subfamily C member 4 (PEL blood group)

multiple interactions

[Curcumin co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC4 protein

NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475

G

ATP binding cassette subfamily C member 5

multiple interactions

[Curcumin analog binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; [Curcumin binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; Curcumin analog binds to and results in decreased activity of ABCC5 protein; Curcumin analog inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]; Curcumin binds to and results in decreased activity of ABCC5 protein; Curcumin inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]

NCBI chr 3:183,919,934...184,017,884
Ensembl chr 3:183,919,934...184,017,939

G

ATP binding cassette subfamily G member 1

increases expression

Curcumin results in increased expression of ABCG1 mRNA

PMID:16713233 PMID:21594647

NCBI chr21:42,199,689...42,297,244
Ensembl chr21:42,199,689...42,297,244

G

ATP binding cassette subfamily G member 2 (JR blood group)

multiple interactions
decreases expression
increases expression

AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein]
Curcumin results in decreased expression of ABCG2 mRNA

PMID:17077187 PMID:33539684

NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628

G

acetyl-CoA carboxylase alpha

increases phosphorylation
decreases expression
affects expression
multiple interactions

Curcumin results in increased phosphorylation of ACACA protein
Curcumin results in decreased expression of ACACA mRNA
Curcumin affects the expression of ACACA mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACA mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACA protein]; Curcumin inhibits the reaction [Dietary Fats results in decreased phosphorylation of ACACA protein]

PMID:18790744 PMID:19297423 PMID:27208389 PMID:37701206

NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836

G

acetyl-CoA carboxylase beta

multiple interactions

Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACB mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACB protein]

NCBI chr12:109,111,189...109,268,226
Ensembl chr12:109,116,587...109,268,226

G

angiotensin I converting enzyme

multiple interactions

Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein]

NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380

G

angiotensin converting enzyme 2

multiple interactions
affects binding

Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein]
Curcumin binds to ACE2 protein

PMID:26648693 PMID:34138966

NCBI chr X:15,518,197...15,607,211
Ensembl chr X:15,494,566...15,607,236

G

acetylcholinesterase (Yt blood group)

multiple interactions
decreases activity

[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of ACHE protein]
Curcumin results in decreased activity of ACHE protein
Curcumin inhibits the reaction [Acrylamide results in increased activity of ACHE protein]; Curcumin inhibits the reaction [aluminum acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE protein]; Curcumin inhibits the reaction [lead acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]

PMID:18809455 PMID:20369229 PMID:21839772 PMID:22783142 PMID:25199698 More...

NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974

G

atypical chemokine receptor 3

increases expression

Curcumin results in increased expression of ACKR3 mRNA

NCBI chr 2:236,537,122...236,582,354
Ensembl chr 2:236,567,787...236,582,354

G

ATP citrate lyase

affects expression
decreases expression

Curcumin affects the expression of ACLY mRNA
Curcumin results in decreased expression of ACLY mRNA

NCBI chr17:41,866,917...41,930,545
Ensembl chr17:41,866,917...41,930,542

G

aconitase 2

multiple interactions

Curcumin inhibits the reaction [Potassium Dichromate results in decreased activity of ACO2 protein]

NCBI chr22:41,469,117...41,528,974
Ensembl chr22:41,447,830...41,529,273

G

actin alpha 2, smooth muscle

multiple interactions
decreases expression

[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Arsenic Trioxide promotes the reaction [Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]]
Curcumin inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
Curcumin results in decreased expression of ACTA2 mRNA; Curcumin results in decreased expression of ACTA2 protein

PMID:17355460 PMID:17531121 PMID:18006644 PMID:22683883 PMID:27363783 More...

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339

G

ADAM metallopeptidase domain 17

multiple interactions

Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA]

NCBI chr 2:9,488,486...9,555,830
Ensembl chr 2:9,488,486...9,556,732

G

ADAM metallopeptidase with thrombospondin type 1 motif 4

increases expression

Curcumin results in increased expression of ADAMTS4 mRNA

NCBI chr 1:161,184,302...161,199,054
Ensembl chr 1:161,184,302...161,199,054

G

adenylate cyclase 9

decreases expression

Curcumin results in decreased expression of ADCY9 mRNA

NCBI chr16:3,953,387...4,116,442
Ensembl chr16:3,953,387...4,116,442

G

adhesion G protein-coupled receptor E1

decreases expression

Curcumin results in decreased expression of ADGRE1 mRNA

NCBI chr19:6,887,579...6,940,450
Ensembl chr19:6,887,566...6,940,459

G

adiponectin, C1Q and collagen domain containing

increases expression
multiple interactions
affects expression

Curcumin results in increased expression of ADIPOQ mRNA; Curcumin results in increased expression of ADIPOQ protein
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]]
Curcumin affects the expression of ADIPOQ mRNA
Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]

PMID:18403477 PMID:26713546 PMID:27208389 PMID:28595985

NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463

G

adenosine A2a receptor

multiple interactions

[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]; Curcumin inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]

NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357

G

advanced glycosylation end-product specific receptor

multiple interactions

2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]

NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322

G

anterior gradient 2, protein disulphide isomerase family member

decreases expression

Curcumin results in decreased expression of AGR2 mRNA

NCBI chr 7:16,791,811...16,804,999
Ensembl chr 7:16,791,811...16,833,433

G

angiotensinogen

multiple interactions

[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD2 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD3 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of AGT protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of AGT protein]

PMID:26612707 PMID:26648693 PMID:31820278

NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576

G

angiotensin II receptor type 2

multiple interactions

Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein]

NCBI chr X:116,170,744...116,174,974
Ensembl chr X:116,170,744...116,174,974

G

aryl hydrocarbon receptor

multiple interactions
affects binding
increases degradation

AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein]
Curcumin binds to AHR protein
Curcumin results in increased degradation of AHR protein
[Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene affects the localization of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of AHR protein]; Curcumin inhibits the reaction [Methylcholanthrene binds to AHR protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]; Curcumin promotes the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]

PMID:17077187 PMID:17880909 PMID:18321868 PMID:19018768 PMID:25632966

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

adenylate kinase 1

multiple interactions

[ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein

NCBI chr 9:127,866,480...127,879,621
Ensembl chr 9:127,866,486...127,877,675

G

A-kinase anchoring protein 6

increases expression
multiple interactions

Curcumin results in increased expression of AKAP6 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA]

PMID:18200517 PMID:18421014

NCBI chr14:32,329,298...32,837,684
Ensembl chr14:32,329,298...32,837,684

G

aldo-keto reductase family 1 member B

increases expression
multiple interactions
increases activity

Curcumin results in increased expression of AKR1B1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]
Curcumin results in increased expression of AKR1B1 mRNA; Curcumin results in increased expression of AKR1B1 protein
Curcumin results in increased activity of AKR1B1 protein

PMID:17640564 PMID:18200517 PMID:18299980 PMID:18588981

NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284

G

AKT serine/threonine kinase 1

multiple interactions
affects phosphorylation
decreases expression
decreases phosphorylation
increases expression
increases phosphorylation
decreases activity

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; MIR532 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]
Curcumin affects the phosphorylation of AKT1 protein
Curcumin analog results in decreased expression of AKT1 mRNA; Curcumin results in decreased expression of AKT1 protein
Curcumin results in increased expression of AKT1 protein
AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of AKT1 protein
AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]
Curcumin results in decreased activity of AKT1 protein

PMID:16023083 PMID:16219905 PMID:17289836 PMID:17291458 PMID:17332930 More...

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

AKT serine/threonine kinase 2

multiple interactions
decreases phosphorylation
decreases expression

4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT2 protein
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]
Curcumin analog results in decreased expression of AKT2 mRNA

PMID:23452621 PMID:26409325 PMID:36640941

NCBI chr19:40,230,317...40,285,345
Ensembl chr19:40,230,317...40,285,536

G

AKT serine/threonine kinase 3

multiple interactions
decreases expression
decreases phosphorylation

4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT3 protein; MIR532 affects the reaction [Curcumin results in decreased expression of AKT3 protein]
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]

PMID:36640941 PMID:37471645

NCBI chr 1:243,488,233...243,851,079
Ensembl chr 1:243,488,233...243,851,079

G

aminolevulinate dehydratase

multiple interactions

[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of ALAD protein]
Curcumin inhibits the reaction [lead acetate results in decreased activity of ALAD protein]

PMID:22704994 PMID:23292317

NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290

G

5'-aminolevulinate synthase 1

increases expression

Curcumin results in increased expression of ALAS1 mRNA

NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327

G

albumin

multiple interactions

[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of ALB protein]; [Curcumin analog co-treated with Hydrogels] results in increased expression of ALB protein; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ALB protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]]

PMID:18204486 PMID:18809455 PMID:20804811 PMID:24704557 PMID:27288928 More...

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

activated leukocyte cell adhesion molecule

decreases expression

Curcumin results in decreased expression of ALCAM mRNA

NCBI chr 3:105,366,909...105,576,900
Ensembl chr 3:105,366,909...105,576,900

G

aldehyde dehydrogenase 1 family member A1

multiple interactions
decreases expression

[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 mRNA]; [Calcitriol co-treated with Paclitaxel] promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; [Curcumin co-treated with Paclitaxel] promotes the reaction [Calcitriol results in decreased expression of ALDH1A1 mRNA]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; Paclitaxel promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]
Curcumin results in decreased expression of ALDH1A1 mRNA; Curcumin results in decreased expression of ALDH1A1 protein
[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]

NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442

G

aldolase, fructose-bisphosphate A

decreases expression

Curcumin results in decreased expression of ALDOA mRNA

NCBI chr16:30,064,279...30,070,420
Ensembl chr16:30,064,164...30,070,457

G

aldolase, fructose-bisphosphate C

decreases expression

Curcumin results in decreased expression of ALDOC mRNA

NCBI chr17:28,573,120...28,576,895
Ensembl chr17:28,573,115...28,576,948

G

arachidonate 5-lipoxygenase

multiple interactions
decreases activity

[Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 protein
Curcumin results in decreased activity of ALOX5 protein

NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119

G

adenosine monophosphate deaminase 1

multiple interactions

Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of AMPD1 protein]

NCBI chr 1:114,673,098...114,695,546
Ensembl chr 1:114,673,090...114,695,618

G

adenosine monophosphate deaminase 3

increases expression

Curcumin results in increased expression of AMPD3 mRNA

NCBI chr11:10,450,388...10,507,579
Ensembl chr11:10,308,313...10,507,579

G

ankyrin repeat domain 37

decreases expression

Curcumin results in decreased expression of ANKRD37 mRNA

NCBI chr 4:185,396,841...185,400,723
Ensembl chr 4:185,396,021...185,400,628

G

ankyrin repeat domain containing 50

decreases expression

Curcumin results in decreased expression of ANKRD50 mRNA

NCBI chr 4:124,664,048...124,712,732
Ensembl chr 4:124,664,048...124,712,732

G

ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1

decreases expression

Curcumin results in decreased expression of ANKZF1 mRNA

NCBI chr 2:219,229,806...219,236,679
Ensembl chr 2:219,229,783...219,236,679

G

amine oxidase copper containing 1

multiple interactions

Curcumin inhibits the reaction [Methotrexate results in increased activity of AOC1 protein]
Curcumin inhibits the reaction [deoxynivalenol results in increased activity of AOC1 protein]

PMID:20885979 PMID:35817260

NCBI chr 7:150,852,120...150,861,504
Ensembl chr 7:150,824,627...150,861,504

G

apoptotic peptidase activating factor 1

increases expression
multiple interactions

Curcumin results in increased expression of APAF1 protein
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA]

PMID:17277231 PMID:20869986

NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,290...98,735,433

G

APC regulator of WNT signaling pathway

decreases expression

Curcumin results in decreased expression of APC mRNA

NCBI chr 5:112,707,498...112,846,239
Ensembl chr 5:112,707,518...112,846,239

G

apolipoprotein E

affects expression

Curcumin affects the expression of APOE mRNA

NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393

G

amyloid beta precursor protein

multiple interactions
increases expression

Curcumin affects the reaction [APP protein binds to APP protein]; Curcumin inhibits the reaction [Copper results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP protein]
Curcumin results in increased expression of APP mRNA
[Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]

PMID:18537544 PMID:18583042 PMID:27793699 PMID:30946834 PMID:31521693

NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128

G

aquaporin 3 (Gill blood group)

decreases expression
multiple interactions

Curcumin results in decreased expression of AQP3 protein
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]

NCBI chr 9:33,441,160...33,447,593
Ensembl chr 9:33,441,156...33,447,596

G

aquaporin 9

increases expression

Curcumin results in increased expression of AQP9 mRNA; Curcumin results in increased expression of AQP9 protein

NCBI chr15:58,138,169...58,185,911
Ensembl chr15:58,138,169...58,185,911

G

androgen receptor

multiple interactions
increases expression
decreases activity
decreases expression

[[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR mRNA; [[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR protein; [Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin promotes the reaction [Quercetin results in increased expression of AR mRNA]; Curcumin promotes the reaction [Quercetin results in increased expression of AR protein]; Quercetin promotes the reaction [Curcumin results in increased expression of AR mRNA]; Quercetin promotes the reaction [Curcumin results in increased expression of AR protein]
Curcumin results in increased expression of AR mRNA; Curcumin results in increased expression of AR protein
Curcumin results in decreased activity of AR protein
Curcumin results in decreased expression of AR mRNA; Curcumin results in decreased expression of AR protein

PMID:12497104 PMID:18676361 PMID:18719366 PMID:22258452 PMID:27132804

NCBI chr X:67,544,021...67,730,619
Ensembl chr X:67,544,021...67,730,619

G

Rho GTPase activating protein 24

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA]

NCBI chr 4:85,475,150...86,002,666
Ensembl chr 4:85,475,150...86,002,668

G

Rho GTPase activating protein 30

decreases expression

Curcumin results in decreased expression of ARHGAP30 mRNA

NCBI chr 1:161,046,946...161,069,891
Ensembl chr 1:161,046,946...161,069,970

G

Rho GDP dissociation inhibitor beta

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARHGDIB mRNA]

NCBI chr12:14,942,015...14,961,601
Ensembl chr12:14,942,031...14,961,728

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions
increases degradation
decreases expression

Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; Curcumin results in increased ubiquitination of and results in increased degradation of ARNT protein
Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
Curcumin results in decreased expression of ARNT protein

PMID:16880289 PMID:17880909 PMID:18682687 PMID:19018768

NCBI chr 1:150,809,713...150,876,599
Ensembl chr 1:150,809,713...150,876,708

G

activating transcription factor 1

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA]

NCBI chr12:50,763,459...50,821,162
Ensembl chr12:50,763,710...50,821,162

G

activating transcription factor 2

decreases expression

Curcumin analog results in decreased expression of ATF2 mRNA

NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382

G

activating transcription factor 3

increases expression

Curcumin results in increased expression of ATF3 mRNA; Curcumin results in increased expression of ATF3 protein

PMID:15713895 PMID:18555241 PMID:18719366

NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777

G

activating transcription factor 4

multiple interactions
decreases expression

ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]
ATF4 inhibits the reaction [Curcumin results in decreased expression of ATF4 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of LDHA protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of PKM protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of SLC2A1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to ATG4B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]

NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683

G

activating transcription factor 6

increases expression

Curcumin results in increased expression of ATF6 protein
Curcumin results in increased expression of ATF6 mRNA

PMID:21793155 PMID:29723631

NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574

G

autophagy related 4B cysteine peptidase

decreases expression
multiple interactions

Curcumin results in decreased expression of ATG4B protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of ATG4B protein]; Curcumin inhibits the reaction [ATF4 protein binds to ATG4B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATG4B protein]

NCBI chr 2:241,637,693...241,673,857
Ensembl chr 2:241,637,213...241,673,857

G

autophagy related 5

multiple interactions
decreases expression

Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATG5 protein]
Curcumin results in decreased expression of ATG5 protein

NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791

G

ATM serine/threonine kinase

multiple interactions
increases phosphorylation

[Isoflavones co-treated with Curcumin] results in increased phosphorylation of ATM protein
Curcumin results in increased phosphorylation of ATM protein

PMID:19401701 PMID:21134073

NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102

G

aurora kinase A

decreases expression

Curcumin analog results in decreased expression of AURKA mRNA

NCBI chr20:56,369,390...56,392,215
Ensembl chr20:56,369,389...56,392,337

G

aurora kinase B

decreases expression

Curcumin analog results in decreased expression of AURKB mRNA

NCBI chr17:8,204,731...8,210,575
Ensembl chr17:8,204,733...8,210,600

G

axin 1

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of AXIN1 mRNA]
Curcumin results in increased expression of AXIN1 mRNA

NCBI chr16:287,440...352,723
Ensembl chr16:287,440...352,723

G

beta-1,3-galactosyltransferase 6

increases expression

Curcumin results in increased expression of B3GALT6 mRNA

NCBI chr 1:1,232,237...1,235,041
Ensembl chr 1:1,232,237...1,235,041

G

beta-secretase 1

multiple interactions
increases expression

Curcumin inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of BACE1 mRNA]
Curcumin results in increased expression of BACE1 mRNA

PMID:18583042 PMID:31521693

NCBI chr11:117,285,698...117,316,256
Ensembl chr11:117,285,232...117,316,259

G

BCL2 associated agonist of cell death

increases expression
multiple interactions

Curcumin results in increased expression of BAD mRNA; Curcumin results in increased expression of BAD protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of BAD protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAD protein]

PMID:15569404 PMID:19235267 PMID:27430728

NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704

G

BCL2 antagonist/killer 1

multiple interactions
decreases expression
increases expression
increases response to substance

TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein]
Curcumin results in decreased expression of BAK1 mRNA
Curcumin results in increased expression of BAK1 mRNA; Curcumin results in increased expression of BAK1 protein
BAK1 protein results in increased susceptibility to Curcumin

PMID:17277231 PMID:17332930 PMID:18226269 PMID:33582110

NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293

G

BCL2 associated X, apoptosis regulator

multiple interactions
affects expression
decreases expression
increases expression
affects localization
increases response to substance

[Arsenic Trioxide co-treated with Curcumin] results in increased expression of BAX protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of BAX protein; [Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Sirolimus] results in increased expression of BAX; [Doxorubicin co-treated with Curcumin] results in increased expression of BAX mRNA; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; Arsenic Trioxide promotes the reaction [Curcumin affects the localization of BAX protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of BAX protein]; Curcumin promotes the reaction [Arsenic Trioxide affects the localization of BAX protein]; Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Curcumin promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of BAX protein]; piperine inhibits the reaction [Curcumin results in decreased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of BAX protein]
Curcumin affects the expression of BAX protein
Curcumin results in decreased expression of BAX mRNA; Curcumin results in decreased expression of BAX protein
Curcumin results in increased expression of BAX mRNA; Curcumin results in increased expression of BAX protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of BAX mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of BAX protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]
BAX protein results in increased susceptibility to Curcumin
[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin affects the localization of and results in increased expression of and results in increased activity of BAX protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX protein]

PMID:15569404 PMID:17096185 PMID:17277231 PMID:17332930 PMID:17531121 More...

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 binding component 3

increases expression
multiple interactions
decreases expression

Curcumin results in increased expression of BBC3 mRNA
Curcumin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein]
Curcumin results in decreased expression of BBC3 mRNA

PMID:17332930 PMID:22714040 PMID:34047412

NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766

G

BCL10 immune signaling adaptor

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL10 mRNA]

NCBI chr 1:85,265,776...85,276,632
Ensembl chr 1:85,265,776...85,276,632

G

BCL2 apoptosis regulator

multiple interactions
increases expression
decreases expression

[Arsenic Trioxide co-treated with Curcumin] affects the expression of BCL2 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in decreased expression of BCL2 protein; [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2 protein; [Curcumin co-treated with Sirolimus] results in decreased expression of BCL2; [Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein; [Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of BCL2 protein; [Doxorubicin co-treated with Curcumin] results in decreased expression of BCL2 mRNA; [piperine co-treated with Curcumin] results in decreased expression of BCL2 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of BCL2 protein; Curcumin inhibits the reaction [Docetaxel results in increased phosphorylation of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin promotes the reaction [Calcitriol promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein]
Curcumin results in increased expression of BCL2 mRNA; Curcumin results in increased expression of BCL2 protein
Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein
Curcumin analog results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in increased expression of BCL2 protein]; Curcumin affects the reaction [Ketamine results in decreased expression of BCL2 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BCL2 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]

PMID:12497104 PMID:14724571 PMID:15569404 PMID:16023083 PMID:16219905 More...

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 related protein A1

multiple interactions
decreases expression

Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]
Curcumin results in decreased expression of BCL2A1 mRNA

PMID:16219905 PMID:17596214

NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196

G

BCL2 like 1

multiple interactions
decreases expression
increases expression

[Curcumin co-treated with Doxorubicin] affects the expression of BCL2L1 mRNA; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2L1 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein]
Curcumin analog results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein]
[Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2L1 protein
Curcumin results in increased expression of BCL2L1 mRNA

PMID:12497104 PMID:15569404 PMID:15911101 PMID:16023083 PMID:16173963 More...

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

BCL2 like 11

increases expression
multiple interactions

Curcumin results in increased expression of BCL2L11 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of BCL2L11 protein

PMID:17332930 PMID:27430728

NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444

G

BCL2 like 2

increases expression
multiple interactions

Curcumin results in increased expression of BCL2L2 mRNA
[arsenic trioxide co-treated with Curcumin] affects the expression of BCL2L2 protein

PMID:16101141 PMID:27430728

NCBI chr14:23,306,833...23,311,751
Ensembl chr14:23,298,790...23,311,751

G

BCL3 transcription coactivator

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BCL3 mRNA]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL3 mRNA]

PMID:18200517 PMID:23452621

NCBI chr19:44,747,705...44,760,044
Ensembl chr19:44,747,705...44,760,044

G

BCL6 corepressor

increases expression

Curcumin results in increased expression of BCOR mRNA

NCBI chr X:40,051,246...40,177,329
Ensembl chr X:40,049,815...40,177,329

G

brain derived neurotrophic factor

multiple interactions
increases expression
affects expression

[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BDNF protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BDNF protein]
Curcumin results in increased expression of BDNF protein
Curcumin affects the expression of BDNF protein
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of BDNF mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BDNF protein]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]

PMID:17022948 PMID:17617388 PMID:17827730 PMID:19033880 PMID:22911773 More...

NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058

G

beclin 1

increases expression
decreases expression

Curcumin results in increased expression of BECN1 protein
Curcumin results in decreased expression of BECN1 protein

PMID:34634291 PMID:36640941

NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350

G

biglycan

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BGN mRNA]

NCBI chr X:153,494,980...153,509,546
Ensembl chr X:153,494,980...153,509,546

G

BH3 interacting domain death agonist

multiple interactions

[arsenic trioxide co-treated with Curcumin] results in decreased expression of BID protein; [arsenic trioxide co-treated with Curcumin] results in increased expression of BID protein; Curcumin promotes the reaction [arsenic trioxide results in increased activity of BID protein]

PMID:20605902 PMID:27430728

NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770

G

baculoviral IAP repeat containing 2

decreases expression
multiple interactions

Curcumin analog results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 protein
Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]

PMID:16023083 PMID:16219905 PMID:16243823 PMID:17596214 PMID:17640567 More...

NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670

G

baculoviral IAP repeat containing 3

multiple interactions
increases expression
decreases expression

[arsenic trioxide co-treated with Curcumin] results in decreased expression of BIRC3 protein; [Curcumin co-treated with Doxorubicin] affects the expression of BIRC3 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC3 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]
[Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC3 protein
Curcumin results in increased expression of BIRC3 mRNA
Curcumin results in decreased expression of BIRC3 mRNA; Curcumin results in decreased expression of BIRC3 protein

PMID:15911101 PMID:16101141 PMID:16219905 PMID:16243823 PMID:17440100 More...

NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403

G

baculoviral IAP repeat containing 5

multiple interactions
decreases expression

[Arsenic Trioxide co-treated with Curcumin] results in decreased expression of BIRC5 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BIRC5 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of BIRC5 protein]
Curcumin inhibits the reaction [Doxorubicin results in decreased expression of BIRC5 protein]
Curcumin analog results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC5 protein

PMID:16023083 PMID:17440100 PMID:17596214 PMID:17671737 PMID:18593936 More...

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

baculoviral IAP repeat containing 7

increases expression
multiple interactions

Curcumin results in increased expression of BIRC7 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of BIRC7 protein

PMID:15911101 PMID:27430728

NCBI chr20:63,235,905...63,240,495
Ensembl chr20:63,235,883...63,240,495

G

bone morphogenetic protein 2

decreases expression

Curcumin results in decreased expression of BMP2 mRNA

NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246

G

BRCA1 DNA repair associated

multiple interactions

Curcumin inhibits the reaction [Furazolidone results in increased expression of BRCA1 protein]

NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245

G

basigin (Ok blood group)

decreases response to substance

BSG protein results in decreased susceptibility to Curcumin

NCBI chr19:571,283...583,493
Ensembl chr19:571,277...583,494

G

complement C1q A chain

decreases expression

Curcumin results in decreased expression of C1QA mRNA

NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,635,077...22,639,678

G

complement C1q B chain

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA]

NCBI chr 1:22,653,236...22,661,637
Ensembl chr 1:22,652,762...22,661,637

G

complement C3

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C3 mRNA]

NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562

G

complement C4B (Chido/Rodgers blood group)

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA]

NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418

G

carbonic anhydrase 9

decreases expression

Curcumin results in decreased expression of CAR9 mRNA

NCBI chr 9:35,673,928...35,681,159
Ensembl chr 9:35,673,928...35,681,159

G

calcium/calmodulin dependent protein kinase II alpha

multiple interactions

[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CAMK2A mRNA
Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CAMK2A protein]

PMID:22911773 PMID:29723552

NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093

G

capping actin protein, gelsolin like

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CAPG mRNA]

NCBI chr 2:85,391,602...85,419,540
Ensembl chr 2:85,394,753...85,418,432

G

caspase 1

increases expression
multiple interactions

Curcumin results in increased expression of CASP1 mRNA
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of CASP1 protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP1 mRNA]

PMID:16101141 PMID:23452621 PMID:34998855 PMID:35063475

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 12 (gene/pseudogene)

increases expression
multiple interactions

Curcumin results in increased expression of CASP12 protein
Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein]

PMID:21793155 PMID:25541178

NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670

G

caspase 2

increases expression

Curcumin results in increased expression of CASP2 mRNA

NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696

G

caspase 3

multiple interactions
decreases expression
increases cleavage
increases activity
decreases activity
increases expression

[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP3 protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased cleavage of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of and results in increased cleavage of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP3 protein; [Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]]
Curcumin results in decreased expression of CASP3 protein modified form
Curcumin results in increased cleavage of CASP3 protein
Curcumin results in decreased activity of CASP3 protein
[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Curcumin results in decreased cleavage of and results in decreased activity of CASP3 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of CASP3 protein; [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP3 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP3 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form]
Curcumin results in increased expression of CASP3 mRNA; Curcumin results in increased expression of CASP3 protein; Curcumin results in increased expression of CASP3 protein modified form
Curcumin analog results in increased activity of CASP3 protein; Curcumin results in increased activity of CASP3; Curcumin results in increased activity of CASP3 protein
Curcumin results in decreased expression of CASP3 mRNA; Curcumin results in decreased expression of CASP3 protein

PMID:15095415 PMID:15569404 PMID:16023083 PMID:16101141 PMID:17041101 More...

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 4

increases expression

Curcumin results in increased expression of CASP4 mRNA

NCBI chr11:104,942,866...104,968,574
Ensembl chr11:104,942,866...104,969,366

G

caspase 7

multiple interactions
increases expression
decreases expression

[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in increased expression of CASP7 protein]; [Curcumin co-treated with Sirolimus] results in increased activity of CASP7 protein; Calcitriol inhibits the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP7 protein
Curcumin results in increased expression of CASP7 protein
Curcumin results in decreased expression of CASP7 mRNA

PMID:16023083 PMID:16101141 PMID:19373661 PMID:31628941

NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907

G

caspase 8

increases activity
multiple interactions
increases cleavage
decreases expression

Curcumin results in increased activity of CASP8 protein
Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]
Curcumin results in increased cleavage of CASP8 protein
Curcumin results in decreased expression of CASP8 mRNA; Curcumin results in decreased expression of CASP8 protein
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP8 protein; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]; Curcumin results in increased cleavage of and results in increased activity of CASP8 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Curcumin results in increased cleavage of CASP8 protein]

PMID:14555224 PMID:16173963 PMID:17096185 PMID:17148446 PMID:22523229 More...

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

decreases expression
multiple interactions
increases activity
increases expression
increases cleavage

Curcumin results in decreased expression of CASP9 mRNA; Curcumin results in decreased expression of CASP9 protein
Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP9 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP9 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP9 mRNA]
Curcumin results in increased activity of CASP9 protein
Curcumin results in increased expression of CASP9 mRNA; Curcumin results in increased expression of CASP9 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of CASP9 protein; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP9 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP9 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein
Curcumin results in increased cleavage of CASP9 protein
[Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in increased expression of CASP9 protein]; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP9 protein; [Doxorubicin co-treated with Curcumin] results in increased expression of CASP9 mRNA; [Paclitaxel co-treated with Calcitriol] promotes the reaction [Curcumin results in increased expression of CASP9 protein]; [Paclitaxel co-treated with Curcumin] promotes the reaction [Calcitriol results in increased expression of CASP9 protein]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]; Curcumin promotes the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein; Paclitaxel promotes the reaction [Curcumin results in increased expression of CASP9 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]]

PMID:14555224 PMID:16023083 PMID:16101141 PMID:17148446 PMID:17277231 More...

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

catalase

multiple interactions
increases expression
increases activity

[arsenite co-treated with Curcumin] results in increased expression of CAT protein; Curcumin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of CAT protein]; Curcumin inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Vehicle Emissions promotes the reaction [Cisplatin results in decreased activity of CAT protein]]; Curcumin inhibits the reaction [Vehicle Emissions results in decreased activity of CAT protein]
Curcumin results in increased expression of CAT protein
Curcumin results in increased activity of CAT protein
Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Chloranil results in decreased activity of CAT protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT]; Curcumin metabolite inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; sodium arsenite inhibits the reaction [Curcumin results in increased activity of CAT protein]
Curcumin results in increased expression of CAT mRNA
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of CAT protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acrylonitrile results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Fenitrothion results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Oxygen deficiency results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT protein]

PMID:16770732 PMID:17076682 PMID:17351913 PMID:17461496 PMID:18299980 More...

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

carbonyl reductase 1

multiple interactions

[[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; Curcumin binds to and results in decreased activity of CBR1 protein; Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; Curcumin inhibits the reaction [NADP metabolite binds to and results in increased activity of CBR1 protein]

NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166

G

cell division cycle and apoptosis regulator 1

increases expression

Curcumin results in increased expression of CCAR1 protein

NCBI chr10:68,721,239...68,792,377
Ensembl chr10:68,721,012...68,792,377

G

coiled-coil domain containing 116

increases expression

Curcumin results in increased expression of CCDC116 mRNA

NCBI chr22:21,632,760...21,637,329
Ensembl chr22:21,632,716...21,637,329

G

C-C motif chemokine ligand 2

multiple interactions
decreases expression
increases expression

Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]
Curcumin results in decreased expression of CCL2 mRNA
Curcumin results in decreased expression of CCL2 mRNA; Curcumin results in decreased expression of CCL2 protein
Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
Curcumin results in increased expression of CCL2 mRNA

PMID:10925121 PMID:11053056 PMID:17198877 PMID:17666914 PMID:18403477 More...

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

cellular communication network factor 2

decreases expression
multiple interactions

Curcumin results in decreased expression of CCN2 mRNA; Curcumin results in decreased expression of CCN2 protein
IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; Lipopolysaccharides inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA]

PMID:17965732 PMID:19764552

NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372

G

cyclin A2

multiple interactions
decreases expression

Curcumin inhibits the reaction [bisphenol A results in increased expression of CCNA2 protein]
Curcumin results in decreased expression of CCNA2 protein

NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883

G

cyclin B1

decreases expression

Curcumin results in decreased expression of CCNB1 mRNA; Curcumin results in decreased expression of CCNB1 protein

PMID:17148446 PMID:18719366 PMID:19401701

NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245

G

cyclin D1

multiple interactions
increases expression
decreases expression
increases degradation

[Curcumin co-treated with Isoflavones] results in decreased expression of CCND1 protein; calyculin A inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]
Curcumin results in increased expression of CCND1 mRNA
Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of CCND1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CCND1 mRNA]
Curcumin results in decreased expression of CCND1; Curcumin results in decreased expression of CCND1 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of CCND1 protein
Curcumin analog results in decreased expression of CCND1 protein; Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein

PMID:15486348 PMID:15489888 PMID:15738001 PMID:16023083 PMID:16219905 More...

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cyclin D3

multiple interactions
decreases expression

Curcumin inhibits the reaction [bisphenol A results in increased expression of CCND3 protein]
Curcumin results in decreased expression of CCND3 protein

NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357

G

cyclin E1

decreases expression
multiple interactions
increases degradation

Curcumin results in decreased expression of CCNE1 protein
Curcumin results in decreased expression of CCNE1 mRNA
Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of CCNE1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCNE1 protein]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein]

PMID:17148446 PMID:18156803 PMID:18299980 PMID:36640941

NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312

G

cell cycle progression 1

increases expression

Curcumin results in increased expression of CCPG1 mRNA

NCBI chr15:55,355,239...55,408,359
Ensembl chr15:55,340,032...55,408,510

G

C-C motif chemokine receptor 2

decreases expression

Curcumin results in decreased expression of CCR2 mRNA

NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940

G

CD14 molecule

multiple interactions

Curcumin inhibits the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased expression of CD14 protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]

NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700

G

CD36 molecule (CD36 blood group)

decreases expression
increases expression
multiple interactions

Curcumin results in decreased expression of CD36 mRNA
Curcumin results in increased expression of CD36 mRNA
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein]
Curcumin results in decreased expression of CD36 mRNA; Curcumin results in decreased expression of CD36 protein

PMID:16713233 PMID:23386263 PMID:23603106

NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277

G

CD40 molecule

decreases expression
multiple interactions

Curcumin results in decreased expression of CD40 mRNA
CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]
[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40 protein

PMID:16101141 PMID:27430728 PMID:35549587

NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863

G

CD40 ligand

multiple interactions

[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40LG protein

NCBI chr X:136,648,158...136,660,390
Ensembl chr X:136,648,158...136,660,390

G

CD44 molecule (IN blood group)

increases expression

Curcumin results in increased expression of CD44 mRNA

NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402

G

CD47 molecule

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA]

NCBI chr 3:108,043,091...108,091,031
Ensembl chr 3:108,043,091...108,091,862

G

CD55 molecule (Cromer blood group)

decreases expression

Curcumin results in decreased expression of CD55 mRNA

NCBI chr 1:207,321,678...207,360,966
Ensembl chr 1:207,321,519...207,386,804

G

cell division cycle 14B

increases expression

Curcumin results in increased expression of CDC14B mRNA

NCBI chr 9:96,490,939...96,619,843
Ensembl chr 9:96,490,241...96,619,843

G

cell division cycle 20

decreases expression

Curcumin results in decreased expression of CDC20 mRNA

NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203

G

cell division cycle 25C

increases phosphorylation

Curcumin results in increased phosphorylation of CDC25C protein

NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355

G

cadherin 1

increases expression
multiple interactions

Curcumin results in increased expression of CDH1 protein
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]
[Curcumin co-treated with Arsenic Trioxide] results in increased expression of CDH1 mRNA; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in decreased expression of CDH1 protein]

PMID:19573523 PMID:25656647 PMID:26191140 PMID:34233590 PMID:35487055 More...

NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537

G

cadherin 11

decreases expression

Curcumin results in decreased expression of CDH11 protein

NCBI chr16:64,943,753...65,123,744
Ensembl chr16:64,943,753...65,126,112

G

cadherin 17

decreases expression

Curcumin results in decreased expression of CDH17 mRNA

NCBI chr 8:94,127,162...94,217,278
Ensembl chr 8:94,127,162...94,217,303

G

cadherin 2

multiple interactions

Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]
Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CDH2 protein]
Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]]

PMID:26191140 PMID:34233590 PMID:35549587

NCBI chr18:27,932,879...28,177,130
Ensembl chr18:27,932,879...28,177,946

G

cyclin dependent kinase 1

decreases expression

Curcumin results in decreased expression of CDK1 mRNA
Curcumin results in decreased expression of CDK1 mRNA; Curcumin results in decreased expression of CDK1 protein

PMID:17148446 PMID:18299980 PMID:19401701 PMID:22258452

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

cyclin dependent kinase 2

multiple interactions
decreases expression

Curcumin inhibits the reaction [bisphenol A results in increased expression of CDK2 protein]
Curcumin results in decreased expression of CDK2 protein
Curcumin analog results in decreased expression of CDK2 mRNA; Curcumin results in decreased expression of CDK2 protein

PMID:19501152 PMID:23222814 PMID:26409325

NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789

G

cyclin dependent kinase 4

decreases expression

Curcumin analog results in decreased expression of CDK4 mRNA; Curcumin results in decreased expression of CDK4 protein

PMID:18156803 PMID:24211270 PMID:26409325

NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013

G

cyclin dependent kinase 5

decreases expression

Curcumin analog results in decreased expression of CDK5 mRNA

NCBI chr 7:151,053,815...151,057,897
Ensembl chr 7:151,053,815...151,057,897

G

cyclin dependent kinase 6

decreases expression

Curcumin results in decreased expression of CDK6 protein

NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573

G

cyclin dependent kinase 7

decreases expression

Curcumin analog results in decreased expression of CDK7 mRNA

NCBI chr 5:69,234,795...69,277,430
Ensembl chr 5:69,234,795...69,277,430

G

cyclin dependent kinase 9

decreases expression

Curcumin analog results in decreased expression of CDK9 mRNA

NCBI chr 9:127,786,034...127,790,792
Ensembl chr 9:127,785,679...127,790,792

G

cyclin dependent kinase inhibitor 1A

multiple interactions
increases expression
decreases expression

[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1A protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [piperine co-treated with Curcumin] results in decreased expression of CDKN1A protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CDKN1A protein]
[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein]
Curcumin results in increased expression of CDKN1A; Curcumin results in increased expression of CDKN1A mRNA; Curcumin results in increased expression of CDKN1A protein
[Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of CDKN1A protein
Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1A protein]

PMID:15713895 PMID:15738001 PMID:17148446 PMID:17332326 PMID:17602960 More...

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337

G

cyclin dependent kinase inhibitor 1B

increases expression
multiple interactions
decreases expression

Curcumin results in increased expression of CDKN1B mRNA; Curcumin results in increased expression of CDKN1B protein
Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein]
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1B protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of CDKN1B protein; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein]
Curcumin results in decreased expression of CDKN1B protein

PMID:15713895 PMID:17602960 PMID:18156803 PMID:18226269 PMID:18593936 More...

NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369

G

cyclin dependent kinase inhibitor 2A

decreases expression
increases expression

Curcumin results in decreased expression of CDKN2A protein
Curcumin results in increased expression of CDKN2A protein

PMID:17148446 PMID:18156803

NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301

G

cyclin dependent kinase inhibitor 2D

decreases expression

Curcumin results in decreased expression of CDKN2D mRNA

NCBI chr19:10,566,460...10,568,979
Ensembl chr19:10,566,460...10,569,059

G

caudal type homeobox 2

increases expression

Curcumin results in increased expression of CDX2 mRNA

PMID:18299980 PMID:27237783

NCBI chr13:27,960,918...27,969,315
Ensembl chr13:27,960,918...27,969,315

G

CCAAT enhancer binding protein alpha

multiple interactions

Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of CEBPA mRNA]

PMID:19297423 PMID:28595985

NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534

G

CCAAT enhancer binding protein beta

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CEBPB mRNA]

NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668

G

carboxylesterase 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA]

NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337

G

carboxylesterase 3

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES3 mRNA]

NCBI chr16:66,961,266...66,975,149
Ensembl chr16:66,961,245...66,975,149

G

CASP8 and FADD like apoptosis regulator

multiple interactions
decreases expression

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]
Curcumin results in decreased expression of CFLAR protein

PMID:16173963 PMID:16219905 PMID:23452621

NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687

G

CF transmembrane conductance regulator

multiple interactions
increases activity
affects localization

[PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Curcumin analog inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid]
Curcumin results in increased activity of CFTR protein; Curcumin results in increased activity of CFTR protein mutant form
Curcumin affects the localization of CFTR protein mutant form
Curcumin affects the folding of and affects the localization of CFTR protein mutant form

PMID:15105504 PMID:15280357 PMID:15582996 PMID:17178710 PMID:23978416

NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971

G

choline O-acetyltransferase

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHAT protein]

NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942

G

checkpoint kinase 1

decreases response to substance
multiple interactions
increases activity
increases phosphorylation

CHEK1 protein results in decreased susceptibility to Curcumin
Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein]
Curcumin results in increased activity of CHEK1 protein
Curcumin results in increased phosphorylation of CHEK1 protein

PMID:18602917 PMID:19401701 PMID:27996348

NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255

G

checkpoint kinase 2

multiple interactions
increases phosphorylation

[Curcumin co-treated with Dihydrotestosterone] results in increased phosphorylation of CHEK2 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of CHEK2 protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein; Flutamide inhibits the reaction [[Dihydrotestosterone co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein]
Curcumin results in increased phosphorylation of CHEK2 protein

NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422

G

cholinergic receptor muscarinic 2

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHRM2 mRNA]

NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions
decreases activity

Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]
Curcumin results in decreased activity of CHUK protein

PMID:15129424 PMID:15489888 PMID:16023083 PMID:16219905

NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596

G

creatine kinase B

multiple interactions

Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]]

PMID:21378372 PMID:29315967

NCBI chr14:103,519,667...103,522,830
Ensembl chr14:103,519,667...103,522,833

G

creatine kinase, M-type

multiple interactions

Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]]

PMID:21378372 PMID:29315967

NCBI chr19:45,306,413...45,322,875
Ensembl chr19:45,306,413...45,322,875

G

chloride channel accessory 4

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CLCA4A mRNA]

NCBI chr 1:86,547,078...86,580,754
Ensembl chr 1:86,547,078...86,580,754

G

chloride voltage-gated channel 6

decreases expression

Curcumin results in decreased expression of CLCN6 mRNA

NCBI chr 1:11,806,191...11,843,130
Ensembl chr 1:11,806,096...11,848,079

G

claudin 1

multiple interactions

Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]

NCBI chr 3:190,305,707...190,322,446
Ensembl chr 3:190,305,707...190,322,446

G

claudin 2

multiple interactions

Curcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2]

NCBI chr X:106,900,164...106,930,861
Ensembl chr X:106,900,164...106,930,861

G

collagen type I alpha 1 chain

multiple interactions
decreases expression

Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]]
Curcumin analog inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]
Curcumin results in decreased expression of COL1A1 mRNA; Curcumin results in decreased expression of COL1A1 protein

PMID:17355460 PMID:17434272 PMID:17531121 PMID:17602960 PMID:17965732 More...

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

G

collagen type I alpha 2 chain

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A2 mRNA]

NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227

G

collagen type XXVII alpha 1 chain

increases expression

Curcumin results in increased expression of COL27A1 mRNA

NCBI chr 9:114,154,098...114,312,511
Ensembl chr 9:114,155,537...114,312,511

G

collagen type II alpha 1 chain

increases expression
multiple interactions

Curcumin results in increased expression of COL2A1 mRNA; Curcumin results in increased expression of COL2A1 protein
[resveratrol co-treated with Curcumin] results in increased expression of COL2A1 protein

PMID:18321735 PMID:19889203

NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554

G

collagen type III alpha 1 chain

multiple interactions

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA]

NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746

G

collagen type IV alpha 1 chain

increases expression
multiple interactions

Curcumin results in increased expression of COL4A1 mRNA
Curcumin analog inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A1 mRNA]

PMID:18200517 PMID:21594647 PMID:28700904

NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,157

G

collagen type IV alpha 2 chain

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A2 mRNA]

NCBI chr13:110,307,284...110,513,209
Ensembl chr13:110,305,812...110,513,209

G

collagen type IV alpha 5 chain

decreases expression

Curcumin results in decreased expression of COL4A5 mRNA

NCBI chr X:108,439,838...108,697,545
Ensembl chr X:108,439,838...108,697,545

G

collagen type V alpha 1 chain

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A1 mRNA]

NCBI chr 9:134,641,803...134,844,843
Ensembl chr 9:134,641,803...134,844,843

G

collagen type V alpha 2 chain

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A2 mRNA]

NCBI chr 2:189,031,898...189,441,111
Ensembl chr 2:189,031,898...189,225,312

G

carnitine palmitoyltransferase 1A

increases expression

Curcumin results in increased expression of CPT1A mRNA

NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410

G

cAMP responsive element binding protein 1

increases expression
multiple interactions
increases phosphorylation

Curcumin results in increased expression of CREB1 mRNA
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CREB1 mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CREB1 protein]
Curcumin results in increased phosphorylation of CREB1 protein

PMID:17022948 PMID:18299980 PMID:22911773 PMID:27966075 PMID:29723552 More...

NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988

G

cAMP responsive element binding protein 3

increases expression

Curcumin results in increased expression of CREB3 mRNA

NCBI chr 9:35,732,666...35,736,999
Ensembl chr 9:35,732,598...35,736,999

G

CREB binding protein

multiple interactions

Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]]

NCBI chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713

G

C-reactive protein

multiple interactions

Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Curcumin inhibits the reaction [lead acetate results in increased secretion of CRP protein]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of CRP protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of CRP protein]

PMID:21378372 PMID:26713546 PMID:30431687 PMID:31820278

NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589

G

crystallin alpha B

multiple interactions

Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein]
[Curcumin co-treated with arsenite] results in increased expression of CRYAB mRNA; [Curcumin co-treated with Cadmium Chloride] results in increased expression of CRYAB protein; Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein]

NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722

G

citrate synthase

affects expression

Curcumin affects the expression of CS mRNA

NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391

G

colony stimulating factor 1

multiple interactions

Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein]

NCBI chr 1:109,910,506...109,930,992
Ensembl chr 1:109,910,242...109,930,992

G

colony stimulating factor 1 receptor

multiple interactions
increases expression

Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein]
Curcumin results in increased expression of CSF1R mRNA

PMID:15129424 PMID:22714040

NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372

G

colony stimulating factor 2 receptor subunit alpha

increases expression

Curcumin results in increased expression of CSF2RA mRNA

NCBI chr  X:1,268,814...1,325,218
NCBI chr  Y:1,268,814...1,325,218
Ensembl chr  Y:1,268,800...1,310,381
Ensembl chr  X:1,268,800...1,310,381

G

colony stimulating factor 2 receptor subunit beta

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CSF2RB mRNA]

NCBI chr22:36,913,628...36,940,439
Ensembl chr22:36,913,628...36,940,439

G

catenin beta 1

decreases expression
increases expression
multiple interactions
decreases phosphorylation
increases degradation

Curcumin analog results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 protein
Curcumin results in increased expression of CTNNB1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of CTNNB1 mRNA]; Curcumin results in decreased phosphorylation of and affects the localization of CTNNB1 protein
Curcumin results in decreased phosphorylation of CTNNB1 protein
[piperine co-treated with Curcumin] results in decreased expression of CTNNB1 protein; Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CTNNB1 protein]
Curcumin analog results in increased degradation of CTNNB1 protein; Curcumin results in increased degradation of CTNNB1 protein

PMID:10783313 PMID:17041101 PMID:19294764 PMID:19573523 PMID:25963729 More...

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

G

cathepsin B

multiple interactions
decreases expression

Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]
Curcumin analog results in decreased expression of CTSB mRNA

PMID:8534267 PMID:26409325

NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533

G

cathepsin D

multiple interactions
decreases expression

Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]
Curcumin analog results in decreased expression of CTSD mRNA

PMID:8534267 PMID:26409325

NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573

G

cathepsin L

decreases expression

Curcumin results in decreased expression of CTSL protein

NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,724,051...87,731,469

G

cathepsin S

decreases expression

Curcumin results in decreased expression of CTSS mRNA

NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,079...150,765,957

G

C-X-C motif chemokine ligand 1

decreases expression
multiple interactions

Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein
Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 mRNA]; Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 protein]
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]

PMID:17999991 PMID:27194111

NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308

G

C-X-C motif chemokine ligand 12

multiple interactions

Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]

NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493

G

C-X-C motif chemokine ligand 14

decreases expression

Curcumin results in decreased expression of CXCL14 mRNA

NCBI chr 5:135,570,679...135,578,991
Ensembl chr 5:135,570,679...135,579,279

G

C-X-C motif chemokine ligand 2

decreases expression
multiple interactions

Curcumin results in decreased expression of CXCL2 mRNA; Curcumin results in decreased expression of CXCL2 protein
Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CXCL2 mRNA]
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA]

PMID:17999991 PMID:18001810 PMID:18200517 PMID:27194111

NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196

G

C-X-C motif chemokine ligand 8

decreases expression
multiple interactions

Curcumin results in decreased expression of CXCL8 protein
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased expression of and results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [Acids results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Acids results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [lauric acid results in increased expression of and results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [Neurotensin results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Neurotensin results in increased expression of CXCL8 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Shiga Toxin results in increased expression of CXCL8 protein]; Curcumin inhibits the reaction [Sodium Fluoride results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Curcumin results in decreased expression of and results in decreased secretion of CXCL8 protein; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CXCL8 protein]

PMID:12216086 PMID:16819191 PMID:17000667 PMID:17151092 PMID:17273796 More...

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

C-X-C motif chemokine receptor 1

increases expression

Curcumin results in increased expression of CXCR1 protein

NCBI chr 2:218,162,841...218,166,962
Ensembl chr 2:218,162,841...218,166,962

G

C-X-C motif chemokine receptor 2

increases expression

Curcumin results in increased expression of CXCR2 protein

NCBI chr 2:218,125,294...218,137,251
Ensembl chr 2:218,125,289...218,137,251

G

C-X-C motif chemokine receptor 4

decreases expression
multiple interactions

Curcumin results in decreased expression of CXCR4 mRNA
Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]

PMID:17198877 PMID:18660423

NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177

G

cytochrome c, somatic

affects localization
multiple interactions

Curcumin affects the localization of CYCS protein
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CYCS protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased expression of CYCS protein

PMID:19235267 PMID:27430728 PMID:33617879

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

cytochrome P450 family 1 subfamily A member 1

multiple interactions
increases activity
increases expression
decreases activity
decreases expression

Acetylcysteine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Curcumin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Decitabine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; trichostatin A affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA]
Curcumin results in increased activity of CYP1A1 protein
Curcumin results in increased expression of CYP1A1 mRNA
Curcumin results in decreased activity of CYP1A1 protein
Curcumin results in decreased expression of CYP1A1 mRNA
Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]

PMID:11454723 PMID:12628514 PMID:15841493 PMID:16288784 PMID:17012224 More...

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

decreases activity
multiple interactions

Curcumin results in decreased activity of CYP1A2 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A2 mRNA]
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]

PMID:15841493 PMID:16288784 PMID:18321868 PMID:34802538 PMID:35063475

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 1 subfamily B member 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]
Curcumin results in decreased expression of CYP1B1 mRNA

PMID:17637178 PMID:19018768

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 24 subfamily A member 1

multiple interactions
increases expression

[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA
Curcumin results in increased expression of CYP24A1 protein

NCBI chr20:54,143,538...54,173,986
Ensembl chr20:54,153,446...54,173,986

G

cytochrome P450 family 2 subfamily D member 6

decreases expression

Curcumin results in decreased expression of CYP2D6 mRNA

NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865

G

cytochrome P450 family 2 subfamily E member 1

affects expression
multiple interactions
increases expression

Curcumin affects the expression of CYP2E1 protein
Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]
Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite promotes the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]
Curcumin inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein]
Curcumin results in increased expression of CYP2E1 mRNA

PMID:16805852 PMID:18539377 PMID:24508477 PMID:30423402 PMID:33350580

NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220

G

cytochrome P450 family 3 subfamily A member 4

multiple interactions
decreases expression
increases expression

[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; Curcumin inhibits the reaction [Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein]; Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Curcumin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]
Curcumin results in decreased expression of CYP3A4 mRNA
Curcumin results in increased expression of CYP3A4 mRNA

PMID:17210444 PMID:17270371 PMID:17965521 PMID:18385293 PMID:20153625 More...

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

cytohesin 4

increases expression

Curcumin results in increased expression of CYTH4 mRNA

NCBI chr22:37,282,508...37,315,341
Ensembl chr22:37,282,027...37,315,341

G

death domain associated protein

increases expression

Curcumin results in increased expression of DAXX mRNA

NCBI chr 6:33,318,558...33,322,959
Ensembl chr 6:33,318,558...33,323,016

G

drebrin 1

multiple interactions

Curcumin inhibits the reaction [Glucose results in decreased expression of DBN1 mRNA]

NCBI chr 5:177,456,610...177,473,634
Ensembl chr 5:177,456,608...177,474,401

G

decorin

increases expression

Curcumin results in increased expression of DCN mRNA

NCBI chr12:91,140,484...91,182,817
Ensembl chr12:91,140,484...91,183,217

G

doublecortin

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of DCX mRNA]
Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of DCX protein]
Curcumin results in increased expression of DCX mRNA

PMID:25963729 PMID:32735850

NCBI chr X:111,293,779...111,412,192
Ensembl chr X:111,293,779...111,412,429

G

DNA damage inducible transcript 3

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]
Curcumin results in increased expression of DDIT3 mRNA; Curcumin results in increased expression of DDIT3 protein

PMID:16613838 PMID:17171638 PMID:18200517 PMID:18719366 PMID:21793155 More...

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

DNA damage inducible transcript 4 like

decreases expression
increases expression

Curcumin results in decreased expression of DDIT4L mRNA
Curcumin results in increased expression of DDIT4L mRNA

PMID:17999991 PMID:18299980

NCBI chr 4:100,185,870...100,190,468
Ensembl chr 4:100,185,870...100,190,782

G

DNA fragmentation factor subunit beta

increases expression
decreases expression

Curcumin results in increased expression of DFFB mRNA; Curcumin results in increased expression of DFFB protein
Curcumin results in decreased expression of DFFB protein

PMID:21397623 PMID:22714040

NCBI chr 1:3,857,476...3,885,429
Ensembl chr 1:3,857,267...3,885,429

G

24-dehydrocholesterol reductase

decreases expression
affects expression

Curcumin results in decreased expression of DHCR24 mRNA
Curcumin affects the expression of DHCR24 mRNA

NCBI chr 1:54,849,627...54,887,195
Ensembl chr 1:54,849,627...54,887,195

G

7-dehydrocholesterol reductase

affects expression
decreases expression

Curcumin affects the expression of DHCR7 mRNA
Curcumin results in decreased expression of DHCR7 mRNA

NCBI chr11:71,434,411...71,448,393
Ensembl chr11:71,428,193...71,452,868

G

dehydrogenase/reductase 1

decreases expression

Curcumin results in decreased expression of DHRS1 mRNA

NCBI chr14:24,290,598...24,299,780
Ensembl chr14:24,290,598...24,299,780

G

diablo IAP-binding mitochondrial protein

affects localization
multiple interactions
increases expression
increases response to substance

Curcumin affects the localization of DIABLO protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of DIABLO protein
Curcumin results in increased expression of DIABLO mRNA
DIABLO protein results in increased susceptibility to Curcumin

PMID:17277231 PMID:23555722 PMID:27430728

NCBI chr12:122,207,662...122,227,456
Ensembl chr12:122,207,668...122,226,062

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression
multiple interactions

Curcumin results in decreased expression of DKK1 mRNA; Curcumin results in decreased expression of DKK1 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 protein]

NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042

G

discs large MAGUK scaffold protein 4

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DLG4 protein]

NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,841

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

Curcumin results in increased expression of DNAJB9 mRNA

NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850

G

dynamin 1 like

multiple interactions

Curcumin inhibits the reaction [Potassium Dichromate results in increased expression of DNM1L protein]

NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650

G

DNA methyltransferase 1

decreases expression
affects expression
increases activity
multiple interactions

Curcumin results in decreased expression of DNMT1 mRNA; Curcumin results in decreased expression of DNMT1 protein
Curcumin analog affects the expression of DNMT1 protein
Curcumin results in increased activity of DNMT1 protein
Curcumin promotes the reaction [Quercetin results in increased activity of DNMT1 protein]; Quercetin promotes the reaction [Curcumin results in increased activity of DNMT1 protein]
Curcumin analog results in decreased expression of DNMT1 protein

PMID:23593078 PMID:26991801 PMID:27132804 PMID:29228771

NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286

G

DNA methyltransferase 3 alpha

decreases expression

Curcumin results in decreased expression of DNMT3A mRNA
Curcumin analog results in decreased expression of DNMT3A protein

PMID:23593078 PMID:26991801 PMID:29228771

NCBI chr 2:25,227,874...25,342,590
Ensembl chr 2:25,227,855...25,342,590

G

DNA methyltransferase 3 beta

decreases expression

Curcumin results in decreased expression of DNMT3B mRNA
Curcumin analog results in decreased expression of DNMT3B protein

PMID:23593078 PMID:26991801 PMID:29228771

NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359

G

DNA damage regulated autophagy modulator 1

increases expression

Curcumin results in increased expression of DRAM1 mRNA

NCBI chr12:101,877,580...101,923,612
Ensembl chr12:101,877,580...102,012,130

G

dopamine receptor D2

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DRD2 protein]

NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691

G

dual specificity phosphatase 1

increases expression
multiple interactions

Curcumin results in increased expression of DUSP1 mRNA
Curcumin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of DUSP1 protein]

PMID:15713895 PMID:20885979

NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195

G

dual specificity phosphatase 10

increases expression

Curcumin results in increased expression of DUSP10 mRNA

PMID:15713895 PMID:17151092

NCBI chr 1:221,701,424...221,742,089
Ensembl chr 1:221,701,424...221,742,089

G

dual specificity phosphatase 5

increases expression

Curcumin results in increased expression of DUSP5 mRNA

NCBI chr10:110,497,907...110,511,533
Ensembl chr10:110,497,907...110,511,533

G

dishevelled segment polarity protein 1

decreases expression
increases expression
multiple interactions

Curcumin results in decreased expression of DVL1 protein
Curcumin results in increased expression of DVL1 mRNA; Curcumin results in increased expression of DVL1 protein
Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 protein]

PMID:19573523 PMID:25963729

NCBI chr 1:1,335,278...1,349,418
Ensembl chr 1:1,335,276...1,349,418

G

dynein light chain LC8-type 1

increases expression

Curcumin results in increased expression of DYNLL1 mRNA

NCBI chr12:120,469,842...120,498,493
Ensembl chr12:120,469,850...120,498,493

G

dual specificity tyrosine phosphorylation regulated kinase 2

multiple interactions
decreases activity

[Curcumin binds to 4-nitrobenzaldehyde] which results in decreased activity of DYRK2 protein
Curcumin results in decreased activity of DYRK2 protein

NCBI chr12:67,648,745...67,665,406
Ensembl chr12:67,648,338...67,665,406

G

E2F transcription factor 1

decreases expression

Curcumin results in decreased expression of E2F1 mRNA

NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385

G

E2F transcription factor 5

decreases expression

Curcumin results in decreased expression of E2F5 mRNA

NCBI chr 8:85,177,154...85,214,518
Ensembl chr 8:85,177,154...85,217,158

G

enoyl-CoA hydratase 1

increases expression

Curcumin results in increased expression of ECH1 mRNA

NCBI chr19:38,815,422...38,831,794
Ensembl chr19:38,815,422...38,831,841

G

EDAR associated via death domain

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA]

NCBI chr 1:236,348,259...236,484,930
Ensembl chr 1:236,348,257...236,502,915

G

EGF like repeats and discoidin domains 3

decreases expression

Curcumin results in decreased expression of EDIL3 mRNA

NCBI chr 5:83,940,554...84,384,880
Ensembl chr 5:83,940,554...84,384,880

G

epidermal growth factor

decreases activity
multiple interactions

Curcumin results in decreased activity of EGF protein
Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein]

PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:18214481

NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766

G

epidermal growth factor receptor

multiple interactions
decreases phosphorylation
decreases expression

Curcumin inhibits the reaction [Acrylamide results in increased expression of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of EGFR protein]; Curcumin results in decreased expression of and results in decreased activity of EGFR protein; Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of EGFR protein]; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein]
Curcumin results in decreased phosphorylation of EGFR protein
Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]
Curcumin analog results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein

PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:17918158 More...

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

early growth response 1

multiple interactions
increases expression
decreases expression

EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of EGR1 protein]; U 0126 inhibits the reaction [Curcumin results in increased expression of EGR1 protein]
Curcumin results in increased expression of EGR1 mRNA; Curcumin results in increased expression of EGR1 protein
Curcumin results in decreased expression of EGR1 mRNA

PMID:17198877 PMID:17999991 PMID:18316600

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

G

eukaryotic translation initiation factor 1

decreases expression

Curcumin results in decreased expression of EIF1 mRNA

NCBI chr17:41,688,885...41,692,668
Ensembl chr17:41,688,885...41,692,668

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
decreases expression
decreases phosphorylation

calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of EIF4EBP1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of EIF4EBP1 protein]
Curcumin results in decreased expression of EIF4EBP1 protein

PMID:18790744 PMID:23222814 PMID:34634291

NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365

G

eukaryotic translation initiation factor 4 gamma 1

decreases phosphorylation

Curcumin results in decreased phosphorylation of EIF4G1 protein

NCBI chr 3:184,314,606...184,335,358
Ensembl chr 3:184,314,495...184,335,358

G

E74 like ETS transcription factor 2

decreases expression

Curcumin results in decreased expression of ELF2 mRNA

NCBI chr 4:139,057,220...139,177,915
Ensembl chr 4:139,028,112...139,177,218

G

ETS transcription factor ELK1

multiple interactions
increases phosphorylation

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ELK1 mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]

PMID:18316600 PMID:23452621

NCBI chr X:47,635,520...47,650,604
Ensembl chr X:47,635,521...47,650,604

G

embigin

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of EMB mRNA]

NCBI chr 5:50,396,192...50,443,345
Ensembl chr 5:50,396,192...50,443,248

G

enolase 1

decreases expression

Curcumin results in decreased expression of ENO1 mRNA

NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190

G

ectonucleoside triphosphate diphosphohydrolase 5 (inactive)

increases expression

Curcumin results in increased expression of ENTPD5 mRNA

NCBI chr14:73,955,329...74,019,288
Ensembl chr14:73,958,010...74,019,399

G

E1A binding protein p300

multiple interactions
decreases activity
decreases expression
affects localization

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]]
Curcumin results in decreased activity of EP300 protein
Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein]
Curcumin results in decreased expression of EP300 mRNA; Curcumin results in decreased expression of EP300 protein

PMID:17927689 PMID:22228707 PMID:22258452 PMID:26612707

NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077

G

endothelial PAS domain protein 1

multiple interactions

Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]

NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697

G

epithelial cell adhesion molecule

multiple interactions
decreases expression

WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM protein]
Curcumin results in decreased expression of EPCAM mRNA; Curcumin results in decreased expression of EPCAM protein

NCBI chr 2:47,369,311...47,387,020
Ensembl chr 2:47,345,158...47,387,601

G

erythropoietin

decreases expression

Curcumin results in decreased expression of EPO mRNA

NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700

G

eosinophil peroxidase

multiple interactions

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of EPX protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of EPX protein]

NCBI chr17:58,192,726...58,205,174
Ensembl chr17:58,192,726...58,205,174

G

erb-b2 receptor tyrosine kinase 2

multiple interactions
increases response to substance
increases degradation
decreases expression

[ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Doxorubicin]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Etoposide]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog promotes the reaction [Cycloheximide results in increased degradation of ERBB2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased expression of and results in decreased activity of ERBB2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein
ERBB2 protein results in increased susceptibility to Curcumin; ERBB2 protein results in increased susceptibility to Curcumin analog
Curcumin analog results in increased degradation of ERBB2 protein
Curcumin analog results in decreased expression of ERBB2 mRNA; Curcumin analog results in decreased expression of ERBB2 protein; Curcumin results in decreased expression of ERBB2 mRNA; Curcumin results in decreased expression of ERBB2 protein

PMID:17041101 PMID:17918158 PMID:18719366 PMID:25866362 PMID:26409325 More...

NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426

G

erb-b2 receptor tyrosine kinase 3

multiple interactions
decreases expression

Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]
Curcumin analog results in decreased expression of ERBB3 mRNA; Curcumin results in decreased expression of ERBB3 mRNA

PMID:15713895 PMID:17918158 PMID:26409325

NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505

G

ERCC excision repair 1, endonuclease non-catalytic subunit

multiple interactions
decreases expression

[Curcumin results in decreased expression of ERCC1 protein] which results in increased susceptibility to Cisplatin; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 protein]
Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA]
Curcumin results in decreased expression of ERCC1 mRNA; Curcumin results in decreased expression of ERCC1 protein

PMID:17596214 PMID:21493726 PMID:22228707

NCBI chr19:45,407,334...45,451,547
Ensembl chr19:45,407,334...45,478,828

G

ERCC excision repair 4, endonuclease catalytic subunit

multiple interactions
decreases expression

Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC4 mRNA]
Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 protein]
Curcumin results in decreased expression of ERCC4 mRNA; Curcumin results in decreased expression of ERCC4 protein

NCBI chr16:13,920,154...13,952,348
Ensembl chr16:13,920,138...13,952,348

G

endoplasmic reticulum to nucleus signaling 1

decreases expression
increases expression

Curcumin results in decreased expression of ERN1 mRNA
Curcumin results in increased expression of ERN1 mRNA

PMID:17999991 PMID:29723631

NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819

G

estrogen receptor 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased degradation of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; Curcumin inhibits the reaction [fulvestrant results in increased degradation of ESR1 protein]
Curcumin results in decreased expression of ESR1 protein

PMID:15899841 PMID:18347134 PMID:23222814 PMID:24211270

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

ETS proto-oncogene 2, transcription factor

decreases expression

Curcumin results in decreased expression of ETS2 protein

NCBI chr21:38,805,183...38,824,955
Ensembl chr21:38,805,183...38,824,955

G

coagulation factor II, thrombin

multiple interactions

Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein]

NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506

G

coagulation factor II thrombin receptor

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA]

NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770

G

coagulation factor III, tissue factor

multiple interactions

Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]

NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759

G

Fas associated via death domain

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA]

NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390

G

fatty acid desaturase 1

affects expression
decreases expression

Curcumin affects the expression of FADS1 mRNA
Curcumin results in decreased expression of FADS1 mRNA

NCBI chr11:61,799,627...61,817,003
Ensembl chr11:61,799,627...61,829,318

G

fatty acid desaturase 2

decreases expression
affects expression

Curcumin results in decreased expression of FADS2 mRNA
Curcumin affects the expression of FADS2 mRNA

NCBI chr11:61,816,203...61,867,354
Ensembl chr11:61,792,980...61,867,354

G

family with sequence similarity 120 member B

decreases expression

Curcumin results in decreased expression of FAM120B mRNA

NCBI chr 6:170,290,703...170,407,067
Ensembl chr 6:170,290,703...170,407,067

G

FA complementation group D2

multiple interactions
decreases expression

Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]
Curcumin results in decreased expression of FANCD2 mRNA

NCBI chr 3:10,026,437...10,101,932
Ensembl chr 3:10,026,370...10,101,932

G

FA complementation group I

multiple interactions
decreases expression

Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]
Curcumin results in decreased expression of FANCI mRNA

NCBI chr15:89,243,979...89,317,259
Ensembl chr15:89,243,945...89,317,261

G

Fas cell surface death receptor

multiple interactions

[arsenic trioxide co-treated with Curcumin] results in increased expression of FAS protein

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fas ligand

multiple interactions
decreases expression

[arsenic trioxide co-treated with Curcumin] results in increased expression of FASLG protein; Curcumin inhibits the reaction [[vorinostat co-treated with Bortezomib] results in increased expression of FASLG protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FASLG mRNA]
Curcumin results in decreased expression of FASLG mRNA

PMID:10925121 PMID:16101141 PMID:17351739 PMID:23452621 PMID:27430728

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

fatty acid synthase

affects expression
decreases expression

Curcumin affects the expression of FASN mRNA; Curcumin affects the expression of FASN protein
Curcumin results in decreased expression of FASN mRNA

NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294

G

fibulin 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FBLN2 mRNA]

NCBI chr 3:13,549,125...13,638,404
Ensembl chr 3:13,549,125...13,638,422

G

Fc gamma receptor IIIa

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FCGR3A mRNA]

NCBI chr 1:161,541,759...161,550,737
Ensembl chr 1:161,541,759...161,550,968

G

farnesyl-diphosphate farnesyltransferase 1

decreases expression

Curcumin results in decreased expression of FDFT1 mRNA

NCBI chr 8:11,795,582...11,839,309
Ensembl chr 8:11,795,573...11,839,395

G

farnesyl diphosphate synthase

increases expression
decreases expression
affects expression

Curcumin results in increased expression of FDPS mRNA
Curcumin results in decreased expression of FDPS mRNA
Curcumin affects the expression of FDPS mRNA

PMID:16713233 PMID:27208389

NCBI chr 1:155,308,866...155,320,665
Ensembl chr 1:155,308,748...155,320,666

G

fibroblast growth factor 2

decreases expression
increases expression

Curcumin results in decreased expression of FGF2 protein
Curcumin results in increased expression of FGF2 protein

NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236

G

fibroblast growth factor 5

decreases expression

Curcumin results in decreased expression of FGF5 mRNA

NCBI chr 4:80,266,588...80,291,017
Ensembl chr 4:80,266,639...80,336,680

G

fibroblast growth factor receptor 2

decreases expression

Curcumin results in decreased expression of FGFR2 mRNA

NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458

G

filamin A interacting protein 1 like

increases expression

Curcumin results in increased expression of FILIP1L mRNA

NCBI chr 3:99,828,811...100,114,501
Ensembl chr 3:99,828,811...100,114,513

G

fission, mitochondrial 1

multiple interactions

Curcumin inhibits the reaction [Cisplatin results in increased expression of FIS1 protein]

NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316

G

fms related receptor tyrosine kinase 1

decreases expression
multiple interactions

Curcumin results in decreased expression of FLT1 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of FLT1 protein]

PMID:18593936 PMID:23845850

NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145

G

fibronectin 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of FN1 protein]
Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]
Curcumin results in decreased expression of FN1 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FN1 mRNA]

PMID:12388107 PMID:18200517 PMID:18555241 PMID:21998146 PMID:22228707

NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073

G

farnesyltransferase, CAAX box, subunit beta

increases expression

Curcumin results in increased expression of FNTB mRNA

NCBI chr14:64,986,895...65,062,650
Ensembl chr14:64,986,895...65,062,652

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions
increases expression

Curcumin results in decreased expression of FOS mRNA
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of FOS protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FOS mRNA]
Curcumin results in increased expression of FOS mRNA
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]

PMID:15713895 PMID:17827730 PMID:17999991 PMID:23452621 PMID:26191140

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

G

FOS like 1, AP-1 transcription factor subunit

multiple interactions
increases ubiquitination

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]
Curcumin results in increased ubiquitination of FOSL1 protein

NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573

G

FOS like 2, AP-1 transcription factor subunit

decreases expression
multiple interactions

Curcumin results in decreased expression of FOSL2 mRNA
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL2 protein]

PMID:17148446 PMID:17999991

NCBI chr 2:28,392,858...28,417,317
Ensembl chr 2:28,392,448...28,417,317

G

forkhead box A1

multiple interactions

Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]]

NCBI chr14:37,589,552...37,595,249
Ensembl chr14:37,589,552...37,596,059

G

forkhead box A2

decreases expression

Curcumin results in decreased expression of FOXA2 mRNA

NCBI chr20:22,580,998...22,585,490
Ensembl chr20:22,580,998...22,585,455

G

forkhead box F2

decreases expression

Curcumin results in decreased expression of FOXF2 mRNA

NCBI chr 6:1,389,576...1,395,603
Ensembl chr 6:1,389,576...1,395,603

G

forkhead box O1

increases expression
decreases phosphorylation

Curcumin results in increased expression of FOXO1 mRNA
Curcumin results in decreased phosphorylation of FOXO1 protein

PMID:18403477 PMID:18790744

NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641

G

formyl peptide receptor 3

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FPR3 mRNA]

NCBI chr19:51,795,157...51,826,190
Ensembl chr19:51,795,157...51,826,190

G

follicle stimulating hormone subunit beta

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein]

NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261

G

follistatin like 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNA]

NCBI chr 3:120,392,293...120,450,992
Ensembl chr 3:120,392,293...120,451,016

G

ferritin light chain

decreases expression

Curcumin results in decreased expression of FTL1 mRNA

NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,966,879

G

FUS RNA binding protein

increases expression
decreases expression

Curcumin results in increased expression of FUS mRNA
Curcumin results in decreased expression of FUS mRNA

PMID:17198877 PMID:17999991

NCBI chr16:31,180,110...31,194,871
Ensembl chr16:31,180,138...31,191,605

G

frizzled class receptor 1

decreases expression

Curcumin results in decreased expression of FZD1 mRNA

NCBI chr 7:91,264,433...91,271,326
Ensembl chr 7:91,264,433...91,271,326

G

glucose-6-phosphatase catalytic subunit 1

affects expression

Curcumin affects the expression of G6PC1 mRNA

NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438

G

glucose-6-phosphate dehydrogenase

increases expression
multiple interactions

Curcumin results in increased expression of G6PD mRNA; Curcumin results in increased expression of G6PDX mRNA
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of G6PD protein]

PMID:18299980 PMID:36924976

NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572

G

gamma-aminobutyric acid type A receptor subunit alpha1

decreases expression

Curcumin results in decreased expression of GABRA1 mRNA

NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981

G

glutamate decarboxylase 1

multiple interactions

Curcumin inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA]

NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151

G

growth arrest and DNA damage inducible alpha

increases expression

Curcumin results in increased expression of GADD45A mRNA

PMID:16101141 PMID:18299980 PMID:18719366

NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334

G

growth arrest specific 6

increases expression

Curcumin results in increased expression of GAS6 mRNA

NCBI chr13:113,820,549...113,864,076
Ensembl chr13:113,820,549...113,864,076

G

GATA binding protein 2

multiple interactions

Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA]

NCBI chr 3:128,479,422...128,493,201
Ensembl chr 3:128,479,427...128,493,201

G

GATA binding protein 4

decreases expression

Curcumin results in decreased expression of GATA4 mRNA; Curcumin results in decreased expression of GATA4 protein

NCBI chr 8:11,676,935...11,760,002
Ensembl chr 8:11,676,959...11,760,002

G

glutamate-cysteine ligase catalytic subunit

increases activity
multiple interactions
increases expression

Curcumin results in increased activity of GCLC protein
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of GCLC mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of GCLC protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]
Curcumin analog results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC mRNA
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]
Curcumin results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC protein
Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC protein]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein]; Curcumin results in increased activity of [GCLC protein binds to GCLM protein]

PMID:10514034 PMID:17602960 PMID:18299980 PMID:18332871 PMID:19168576 More...

NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970

G

glutamate-cysteine ligase modifier subunit

multiple interactions
increases expression

Curcumin results in increased activity of [GCLC protein binds to GCLM protein]
Curcumin promotes the reaction [sodium arsenite results in increased expression of GCLM mRNA]
Curcumin analog results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM protein
NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLM mRNA]

PMID:17198877 PMID:17535857 PMID:17602960 PMID:17999991 PMID:18332871 More...

NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456

G

guanine deaminase

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GDA mRNA]

NCBI chr 9:72,114,608...72,259,869
Ensembl chr 9:72,114,595...72,257,193

G

glial fibrillary acidic protein

decreases expression
multiple interactions

Curcumin results in decreased expression of GFAP mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of GFAP mRNA]

PMID:19555370 PMID:25963729

NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937

G

gamma-glutamyltransferase 1

increases expression
multiple interactions

Curcumin results in increased expression of GGT1 mRNA
Curcumin inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]

PMID:18299980 PMID:24704557

NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005

G

glycoprotein alpha-galactosyltransferase 1 (inactive)

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GGTA1 mRNA]

NCBI chr 9:121,444,990...121,499,844
Ensembl chr 9:121,444,991...121,499,844

G

gap junction protein alpha 1

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]

NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727

G

GLI family zinc finger 1

decreases expression
multiple interactions

Curcumin results in decreased expression of GLI1 mRNA; Curcumin results in decreased expression of GLI1 protein
[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of GLI1 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of GLI1 protein]

PMID:20395211 PMID:31612257

NCBI chr12:57,459,785...57,472,268
Ensembl chr12:57,459,785...57,472,268

G

GLI family zinc finger 2

multiple interactions

Curcumin inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]]

NCBI chr 2:120,735,868...120,992,653
Ensembl chr 2:120,735,623...120,992,653

G

glyoxalase I

decreases activity

Curcumin results in decreased activity of GLO1 protein

NCBI chr 6:38,675,925...38,703,145
Ensembl chr 6:38,675,925...38,703,145

G

glutamic-oxaloacetic transaminase 1

multiple interactions

Curcumin inhibits the reaction [aristolochic acid I results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [Iron results in increased activity of GOT1 protein]

PMID:16956363 PMID:36037877

NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624

G

glutamic-oxaloacetic transaminase 1 like 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GOT1L1 mRNA]

NCBI chr 8:37,934,281...37,940,124
Ensembl chr 8:37,934,281...37,940,124

G

glycerol-3-phosphate acyltransferase, mitochondrial

decreases expression
affects expression
multiple interactions

Curcumin results in decreased expression of GPAM mRNA
Curcumin affects the expression of GPAM mRNA
Curcumin inhibits the reaction [Dietary Fats results in increased expression of GPAM mRNA]

PMID:19297423 PMID:27208389

NCBI chr10:112,149,865...112,227,677
Ensembl chr10:112,149,865...112,215,377

G

G protein-coupled estrogen receptor 1

decreases expression

Curcumin results in decreased expression of GPER1 mRNA

NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815

G

gephyrin

affects expression

Curcumin affects the expression of GPHN mRNA

NCBI chr14:66,508,147...67,735,355
Ensembl chr14:66,507,407...67,181,803

G

glutamic--pyruvic transaminase

multiple interactions

[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Curcumin inhibits the reaction [Acetaminophen affects the activity of GPT protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased activity of GPT protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased activity of GPT protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of GPT protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GPT protein]; Curcumin inhibits the reaction [Iron results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of GPT protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Curcumin inhibits the reaction [bisphenol A results in increased activity of GPT protein]; Curcumin inhibits the reaction [Chloranil results in increased activity of GPT protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of GPT protein]

PMID:16956363 PMID:20804811 PMID:24704557 PMID:25123790 PMID:27288928 More...

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

glutathione peroxidase 1

decreases expression
multiple interactions

Curcumin results in decreased expression of GPX1 mRNA
Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of GPX1 protein]
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA]
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased expression of GPX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]

PMID:18299980 PMID:19914224 PMID:23267840 PMID:30934151 PMID:36924976

NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605

G

growth factor receptor bound protein 10

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GRB10 mRNA]

NCBI chr 7:50,590,068...50,793,453
Ensembl chr 7:50,590,063...50,793,462

G

growth factor receptor bound protein 2

decreases expression

Curcumin analog results in decreased expression of GRB2 mRNA

NCBI chr17:75,318,076...75,405,678
Ensembl chr17:75,318,076...75,405,709

G

gremlin 1, DAN family BMP antagonist

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GREM1 mRNA]

NCBI chr15:32,718,004...32,745,106
Ensembl chr15:32,718,004...32,745,106

G

glutamate ionotropic receptor AMPA type subunit 4

multiple interactions

Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIA4 protein]

NCBI chr11:105,609,616...105,982,090
Ensembl chr11:105,609,535...105,982,090

G

glutamate ionotropic receptor NMDA type subunit 1

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 protein]

PMID:23267840 PMID:29723552

NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756

G

glutamate ionotropic receptor NMDA type subunit 2A

multiple interactions

Curcumin inhibits the reaction [aluminum acetate results in decreased expression of GRIN2A protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A protein]

PMID:25496357 PMID:29723552

NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions

Curcumin inhibits the reaction [aluminum acetate results in decreased expression of GRIN2B protein]

NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002

G

glutamate metabotropic receptor 2

decreases expression

Curcumin results in decreased expression of GRM2 protein

NCBI chr 3:51,707,068...51,718,613
Ensembl chr 3:51,707,068...51,718,613

G

gasdermin D

multiple interactions

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of GSDMD protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of GSDMD mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of GSDMD protein]

PMID:34998855 PMID:35063475

NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062

G

glycogen synthase kinase 3 beta

decreases phosphorylation
decreases expression
multiple interactions
increases phosphorylation
increases expression

Curcumin results in decreased phosphorylation of GSK3B protein
Curcumin results in decreased expression of GSK3B mRNA
Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; Curcumin results in increased expression of and results in increased phosphorylation of GSK3B protein
Curcumin results in increased phosphorylation of GSK3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of GSK3B mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and affects the localization of GSK3B protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein]
Curcumin results in increased expression of GSK3B protein

PMID:18006147 PMID:18790744 PMID:19573523 PMID:25541178 PMID:25963729 More...

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

gelsolin

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GSN mRNA]

NCBI chr 9:121,201,483...121,332,842
Ensembl chr 9:121,207,794...121,332,843

G

glutathione-disulfide reductase

increases expression
multiple interactions

Curcumin results in increased expression of GSR mRNA
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of GSR protein]
[Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GSR]
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of GSR protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Fenitrothion results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]

PMID:19168576 PMID:19914224 PMID:20593964 PMID:21976817 PMID:24347089 More...

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

glutathione synthetase

increases expression
multiple interactions

Curcumin results in increased expression of GSS mRNA
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GSS mRNA]

PMID:19183254 PMID:35063475

NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027

G

glutathione S-transferase alpha 4

increases activity

Curcumin results in increased activity of GSTA4 protein

NCBI chr 6:52,977,953...52,995,284
Ensembl chr 6:52,977,948...52,995,304

G

glutathione S-transferase alpha 5

increases expression

Curcumin results in increased expression of GSTA5 mRNA

NCBI chr 6:52,831,692...52,846,245
Ensembl chr 6:52,831,655...52,840,843

G

glutathione S-transferase kappa 1

multiple interactions

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GSTK1 mRNA]

NCBI chr 7:143,263,441...143,269,115
Ensembl chr 7:143,244,093...143,270,854

G

glutathione S-transferase omega 1

increases expression
multiple interactions

Curcumin results in increased expression of GSTO1 mRNA
Curcumin promotes the reaction [sodium arsenite results in increased expression of GSTO1 mRNA]

NCBI chr10:104,254,173...104,267,455
Ensembl chr10:104,235,356...104,267,459

G

glutathione S-transferase pi 1

multiple interactions
affects expression
increases expression
decreases expression

[sulfinosine co-treated with Curcumin] results in decreased expression of GSTP1 mRNA; Curcumin binds to and results in decreased activity of GSTP1 protein; Curcumin inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; Curcumin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to GSTP1 promoter]; Curcumin promotes the reaction [NFE2L2 protein results in increased expression of GSTP1 mRNA]
Curcumin affects the expression of GSTP1 protein
Curcumin results in increased expression of GSTP1 mRNA
Curcumin results in decreased expression of GSTP1 mRNA; Curcumin results in decreased expression of GSTP1 protein
Curcumin results in increased expression of GSTP1 mRNA; Curcumin results in increased expression of GSTP1 protein

PMID:9463521 PMID:14555224 PMID:14742295 PMID:15999103 PMID:16101141 More...

NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656

G

glucuronidase beta

multiple interactions

Curcumin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215

G

H1.10 linker histone

decreases expression

Curcumin results in decreased expression of H1-10 mRNA

NCBI chr 3:129,314,771...129,316,286
Ensembl chr 3:129,314,771...129,316,286

G

H19 imprinted maternally expressed transcript

decreases expression
multiple interactions

Curcumin results in decreased expression of H19 mRNA
curcumin inhibits the reaction [platelet- derived growth factor increases expression of H19 RNA in aortic vascular smooth muscle cells]
curcumin inhibits the reaction [carotid balloon injury increases expression of H19 RNA in carotid artery segment]

CTD
RGD

PMID:18348204 PMID:34487706 PMID:34487706

RGD:156430326, RGD:156430326

NCBI chr11:1,995,176...2,001,466
Ensembl chr11:1,995,166...2,004,552

G

H2A.X variant histone

multiple interactions
increases phosphorylation

[Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AX protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of H2AX protein
Curcumin results in increased phosphorylation of H2AX protein

PMID:19401701 PMID:21134073

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

H2B clustered histone 26

increases expression

Curcumin results in increased expression of H2BC26 mRNA

NCBI chr 1:228,458,103...228,458,558
Ensembl chr 1:228,458,103...228,463,104

G

H2B clustered histone 5

increases expression

Curcumin results in increased expression of H2BC5 mRNA

NCBI chr 6:26,158,121...26,171,349
Ensembl chr 6:26,158,122...26,171,349

G

H2B clustered histone 7

increases expression

Curcumin results in increased expression of HIST1H2BQ mRNA

NCBI chr 6:26,199,516...26,199,988
Ensembl chr 6:26,199,516...26,199,988

G

H3.4 histone, cluster member

increases phosphorylation
increases acetylation

Curcumin results in increased phosphorylation of H3F4 protein
Curcumin results in increased acetylation of H3F4 protein

NCBI chr 1:228,424,845...228,425,360
Ensembl chr 1:228,424,845...228,425,360

G

H4 clustered histone 11

increases expression

Curcumin results in increased expression of H4C11 mRNA

NCBI chr 6:27,824,092...27,824,480
Ensembl chr 6:27,824,092...27,824,480

G

H4 clustered histone 15

increases expression

Curcumin results in increased expression of H4C15 mRNA

NCBI chr 1:149,844,488...149,861,240
Ensembl chr 1:149,854,045...149,861,159

G

hepcidin antimicrobial peptide

decreases expression

Curcumin results in decreased expression of HAMP mRNA

NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143

G

heart and neural crest derivatives expressed 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [Alcohols results in increased expression of HAND1 mRNA]
Curcumin results in decreased expression of HAND1 mRNA

NCBI chr 5:154,474,972...154,478,227
Ensembl chr 5:154,474,972...154,478,227

G

heart and neural crest derivatives expressed 2

multiple interactions
decreases expression

Curcumin inhibits the reaction [Alcohols results in increased expression of HAND2 mRNA]
Curcumin results in decreased expression of HAND2 mRNA

NCBI chr 4:173,526,091...173,530,229
Ensembl chr 4:173,524,969...173,530,229

G

hepatitis A virus cellular receptor 1

multiple interactions

Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased export of HAVCR1 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [maleic acid results in increased expression of HAVCR1 protein]

PMID:25119790 PMID:29421648 PMID:30431687

NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396

G

HBS1 like translational GTPase

decreases expression

Curcumin results in decreased expression of HBS1L mRNA

NCBI chr 6:134,960,378...135,054,822
Ensembl chr 6:134,960,378...135,103,056

G

HCK proto-oncogene, Src family tyrosine kinase

multiple interactions
decreases activity

[Curcumin binds to 3,4,5-trimethoxybenzaldehyde] which results in decreased activity of HCK protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [HCK protein binds to Adenosine Triphosphate]; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which binds to and results in decreased phosphorylation of and results in decreased activity of HCK protein
Curcumin analog results in decreased activity of HCK protein

NCBI chr20:32,052,242...32,101,856
Ensembl chr20:32,052,197...32,101,856

G

histone deacetylase 1

multiple interactions
decreases expression
affects localization

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 protein]
Curcumin analog results in decreased expression of HDAC1 protein
Curcumin analog results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 protein

PMID:17927689 PMID:18161303 PMID:23593078 PMID:26409325 PMID:29228771

NCBI chr 1:32,292,083...32,333,626
Ensembl chr 1:32,292,083...32,333,635

G

histone deacetylase 11

decreases expression

Curcumin analog results in decreased expression of HDAC11 mRNA

NCBI chr 3:13,480,306...13,506,416
Ensembl chr 3:13,479,724...13,506,424

G

histone deacetylase 2

multiple interactions
decreases expression

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in increased degradation of and results in decreased expression of HDAC2 protein]
Curcumin analog results in decreased expression of HDAC2 mRNA

PMID:18421014 PMID:26409325

NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308

G

histone deacetylase 3

decreases expression

Curcumin results in decreased expression of HDAC3 protein

NCBI chr 5:141,620,881...141,636,849
Ensembl chr 5:141,620,876...141,636,849

G

histone deacetylase 4

decreases expression

Curcumin analog results in decreased expression of HDAC4 mRNA
Curcumin analog results in decreased expression of HDAC4 protein

PMID:26409325 PMID:26991801 PMID:29228771

NCBI chr 2:239,048,168...239,401,649
Ensembl chr 2:239,048,168...239,401,654

G

histone deacetylase 6

decreases expression

Curcumin analog results in decreased expression of HDAC6 mRNA

NCBI chr X:48,801,398...48,824,982
Ensembl chr X:48,801,377...48,824,982

G

histone deacetylase 7

decreases expression

Curcumin analog results in decreased expression of HDAC7 protein

NCBI chr12:47,782,722...47,821,344
Ensembl chr12:47,782,722...47,833,132

G

histone deacetylase 8

decreases expression

Curcumin analog results in decreased expression of HDAC8 mRNA

NCBI chr X:72,329,516...72,572,843
Ensembl chr X:72,329,516...72,573,101

G

heme binding protein 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HEBP2 mRNA]

NCBI chr 6:138,403,531...138,422,197
Ensembl chr 6:138,403,531...138,422,197

G

hes family bHLH transcription factor 1

multiple interactions

[1,2-Dimethylhydrazine co-treated with Curcumin] results in increased expression of HES1 mRNA

NCBI chr 3:194,136,148...194,138,732
Ensembl chr 3:194,136,148...194,138,732

G

hepatocyte growth factor

increases expression
decreases expression

Curcumin results in increased expression of HGF protein
Curcumin results in decreased expression of HGF protein

NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
decreases expression
decreases activity

[Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Curcumin analog co-treated with terpestacin] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Curcumin analog co-treated with Vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein modified form]; Curcumin analog inhibits the reaction [Ionomycin promotes the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; Curcumin analog inhibits the reaction [Ionomycin results in increased activity of HIF1A protein]; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of HIF1A protein]; Curcumin results in decreased expression of and results in decreased activity of HIF1A protein; VHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein]
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HIF1A mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HIF1A protein]
Curcumin results in decreased expression of HIF1A mRNA
Curcumin analog results in decreased expression of HIF1A mRNA; Curcumin results in decreased expression of HIF1A mRNA
Curcumin results in decreased activity of HIF1A protein

PMID:16880289 PMID:18682687 PMID:20554536 PMID:21397623 PMID:23845850 More...

NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259

G

hexokinase 1

multiple interactions

Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of HK1 protein]

NCBI chr10:69,270,000...69,401,882
Ensembl chr10:69,269,984...69,401,884

G

hexokinase 2

multiple interactions
decreases expression

4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; Curcumin promotes the reaction [Sirolimus results in decreased expression of HK2 protein]

NCBI chr 2:74,834,127...74,893,359
Ensembl chr 2:74,834,127...74,893,359

G

major histocompatibility complex, class II, DP beta 2 (pseudogene)

decreases expression

Curcumin results in decreased expression of HLA-DPB2 mRNA

NCBI chr 6:33,112,516...33,129,113
Ensembl chr 6:33,112,516...33,129,084

G

high mobility group box 1

multiple interactions

2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]]; Curcumin inhibits the reaction [Carbon Tetrachloride affects the localization of and affects the secretion of HMGB1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]

PMID:22683883 PMID:29480285

NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression
multiple interactions
decreases expression
affects expression

Curcumin results in increased expression of HMGCR mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of HMGCR protein]
Curcumin results in decreased expression of HMGCR mRNA
Curcumin affects the expression of HMGCR mRNA; Curcumin affects the expression of HMGCR protein

PMID:16713233 PMID:27208389 PMID:37701206

NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

Curcumin results in decreased expression of HMGCS1 mRNA

NCBI chr 5:43,287,470...43,313,412
Ensembl chr 5:43,287,470...43,313,512

G

heme oxygenase 1

multiple interactions
decreases expression
increases expression
decreases response to substance
increases activity

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [quinocetone results in increased activity of HMOX1 protein]; Curcumin promotes the reaction [quinocetone results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; Cycloheximide inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Egtazic Acid inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Go 6976 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; MAPK14 protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]]; PRKCA protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; PRKCD protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Curcumin results in increased activity of HMOX1 protein]
Curcumin results in decreased expression of HMOX1 mRNA
Curcumin analog results in increased expression of HMOX1 mRNA; Curcumin analog results in increased expression of HMOX1 protein; Curcumin results in increased expression of HMOX1 mRNA; Curcumin results in increased expression of HMOX1 protein
[chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]] which results in increased expression of HMOX1 protein; [Curcumin co-treated with Chloranil] results in increased expression of HMOX1 protein; [Curcumin co-treated with piperine] results in increased expression of HMOX1 mRNA; [Curcumin co-treated with piperine] results in increased expression of HMOX1 protein; [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [[Curcumin co-treated with piperine] results in increased expression of HMOX1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of HMOX1 mRNA]; Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; KEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form affects the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]
Curcumin analog results in increased expression of HMOX1 mRNA; Curcumin analog results in increased expression of HMOX1 protein; Curcumin results in increased expression of HMOX1; Curcumin results in increased expression of HMOX1 mRNA; Curcumin results in increased expression of HMOX1 protein
HMOX1 protein results in decreased susceptibility to Curcumin
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]]; [Curcumin co-treated with Fructose] results in increased expression of HMOX1 protein; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Atrazine results in increased activity of HMOX1 protein]; Curcumin inhibits the reaction [decamethrin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Ethanol results in decreased activity of HMOX1 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Paraquat results in increased activity of HMOX1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]]; Quartz promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; tin protoporphyrin IX inhibits the reaction [Curcumin results in increased activity of HMOX1 protein]

PMID:10925121 PMID:14742295 PMID:17464175 PMID:17535857 PMID:17627722 More...

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

heterogeneous nuclear ribonucleoprotein A1

decreases expression

Curcumin results in decreased expression of HNRNPA1 mRNA

NCBI chr12:54,280,726...54,287,087
Ensembl chr12:54,280,193...54,287,088

G

heterogeneous nuclear ribonucleoprotein D

decreases expression

Curcumin results in decreased expression of HNRNPD mRNA

NCBI chr 4:82,352,498...82,373,991
Ensembl chr 4:82,352,498...82,374,503

G

HOP homeobox

increases expression

Curcumin results in increased expression of HOPX mRNA

NCBI chr 4:56,647,998...56,681,706
Ensembl chr 4:56,647,989...56,681,877

G

homeobox B5

increases expression

Curcumin results in increased expression of HOXB5 mRNA

NCBI chr17:48,591,257...48,593,779
Ensembl chr17:48,591,257...48,593,779

G

hypoxanthine phosphoribosyltransferase 1

increases expression

Curcumin results in increased expression of HPRT1 mRNA

NCBI chr X:134,460,165...134,500,668
Ensembl chr X:134,460,165...134,520,513

G

heat shock transcription factor 1

multiple interactions

Curcumin promotes the reaction [HSF1 protein binds to HSF1 protein]
[arsenite co-treated with Curcumin] results in increased phosphorylation of HSF1 protein

PMID:9764755 PMID:11322385

NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720

G

heat shock protein 90 alpha family class A member 1

decreases expression

Curcumin analog results in decreased expression of HSP90AA1 mRNA

NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699

G

heat shock protein 90 alpha family class B member 1

multiple interactions

Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSP90AB1 mRNA]

NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888

G

heat shock protein 90 beta family member 1

decreases expression

Curcumin analog results in decreased expression of HSP90B1 mRNA

NCBI chr12:103,930,410...103,947,926
Ensembl chr12:103,930,107...103,953,931

G

heat shock protein family A (Hsp70) member 1A

increases expression
multiple interactions
decreases expression

Curcumin results in increased expression of HSPA1A mRNA; Curcumin results in increased expression of HSPA1A protein
Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPA1A mRNA]
Curcumin results in decreased expression of HSPA1A protein

PMID:23555722 PMID:26361869

NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946

G

heat shock protein family A (Hsp70) member 4

increases expression

Curcumin results in increased expression of HSPA4 mRNA; Curcumin results in increased expression of HSPA4 protein

NCBI chr 5:133,052,013...133,106,449
Ensembl chr 5:133,052,013...133,106,449

G

heat shock protein family A (Hsp70) member 5

increases expression
decreases expression
multiple interactions

Curcumin results in increased expression of HSPA5 mRNA
Curcumin results in decreased expression of HSPA5 protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of HSPA5 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of HSPA5 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]

PMID:18200517 PMID:27996348 PMID:29723631 PMID:36640941

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

heat shock protein family B (small) member 1

multiple interactions

Curcumin inhibits the reaction [Streptozocin results in increased expression of HSPB1 protein]; Curcumin promotes the reaction [Isoproterenol results in increased expression of HSPB1 protein]

PMID:18204486 PMID:20125031

NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295

G

heat shock protein family B (small) member 7

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HSPB7 mRNA]

NCBI chr 1:16,014,029...16,019,594
Ensembl chr 1:16,014,028...16,019,594

G

heat shock protein family D (Hsp60) member 1

multiple interactions

Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPD1 mRNA]
[arsenic trioxide co-treated with Curcumin] results in increased expression of HSPD1 protein

PMID:26361869 PMID:27430728

NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737

G

5-hydroxytryptamine receptor 1A

affects expression

Curcumin affects the expression of HTR1A mRNA

NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507

G

intercellular adhesion molecule 1

multiple interactions
decreases expression
affects expression

[Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
Curcumin analog inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Methotrexate results in increased expression of ICAM1 mRNA]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]
[chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]] which results in increased expression of HMOX1 protein; [Curcumin co-treated with Gemcitabine] results in decreased expression of ICAM1 protein; [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 mRNA]
Curcumin results in decreased expression of ICAM1 protein
Curcumin affects the expression of ICAM1 mRNA

PMID:16219905 PMID:16243823 PMID:17440100 PMID:17666914 PMID:17973899 More...

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

inhibitor of DNA binding 1

decreases expression

Curcumin results in decreased expression of ID1 mRNA

NCBI chr20:31,605,289...31,606,510
Ensembl chr20:31,605,283...31,606,515

G

inhibitor of DNA binding 2

decreases expression

Curcumin results in decreased expression of ID2 mRNA

NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461

G

inhibitor of DNA binding 3

decreases expression

Curcumin results in decreased expression of ID3 mRNA

NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501

G

indoleamine 2,3-dioxygenase 1

decreases expression

Curcumin results in decreased expression of IDO1 mRNA

NCBI chr 8:39,913,891...39,928,790
Ensembl chr 8:39,902,275...39,928,790

G

interferon alpha 1

multiple interactions

Curcumin inhibits the reaction [IFNA1 protein results in increased expression of IFNAR2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IFNA1 mRNA]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IL10 protein]

PMID:17979888 PMID:23452621

NCBI chr 9:21,440,439...21,441,316
Ensembl chr 9:21,440,439...21,441,316

G

interferon alpha and beta receptor subunit 1

multiple interactions

Curcumin promotes the reaction [IFNA1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR1 protein]

NCBI chr21:33,324,395...33,359,864
Ensembl chr21:33,324,387...33,359,864

G

interferon alpha and beta receptor subunit 2

multiple interactions

Curcumin inhibits the reaction [IFNA1 protein results in increased expression of IFNAR2 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR2 protein]

NCBI chr21:33,229,938...33,265,664
Ensembl chr21:33,205,282...33,265,675

G

interferon beta 1

multiple interactions

Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR2 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IL10 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased phosphorylation of STAT4 protein]

NCBI chr 9:21,077,104...21,077,942
Ensembl chr 9:21,077,104...21,077,942

G

interferon gamma

multiple interactions
increases secretion

Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT1 protein]; Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IFNG mRNA]
[Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; Curcumin inhibits the reaction [sodium arsenite affects the expression of IFNG mRNA]; tin protoporphyrin IX inhibits the reaction [[Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]
Curcumin results in increased secretion of IFNG protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of IFNG protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IFNG protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein]

PMID:16782535 PMID:16867261 PMID:16959222 PMID:18006644 PMID:22714040 More...

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

interferon kappa

decreases expression

Curcumin results in decreased expression of IFNK mRNA

NCBI chr 9:27,524,290...27,526,498
Ensembl chr 9:27,524,290...27,526,498

G

insulin like growth factor 1

decreases activity
multiple interactions
decreases expression
decreases secretion

Curcumin results in decreased activity of IGF1 protein
Curcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Curcumin inhibits the reaction [IGF1 protein results in increased activity of IGF1R protein]
Curcumin analog results in decreased expression of IGF1 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGF1 mRNA]
Curcumin results in decreased secretion of IGF1 protein

PMID:17458902 PMID:17499312 PMID:18200517 PMID:26409325

NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744

G

insulin like growth factor 1 receptor

multiple interactions
decreases expression

Curcumin inhibits the reaction [IGF1 protein results in increased activity of IGF1R protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of IGF1R protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein]
Curcumin analog results in decreased expression of IGF1R mRNA; Curcumin results in decreased expression of IGF1R mRNA

PMID:17499312 PMID:17918158 PMID:26409325

NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530

G

insulin like growth factor 2

decreases expression
multiple interactions

Curcumin analog results in decreased expression of IGF2 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGF2 protein

PMID:26409325 PMID:27430728

NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391

G

insulin like growth factor binding protein 1

multiple interactions

[arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP1 protein

NCBI chr 7:45,888,488...45,893,660
Ensembl chr 7:45,888,360...45,893,660

G

insulin like growth factor binding protein 2

multiple interactions

[arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP2 protein

NCBI chr 2:216,632,828...216,664,436
Ensembl chr 2:216,632,828...216,664,436

G

insulin like growth factor binding protein 3

decreases expression
multiple interactions
increases secretion
increases expression

Curcumin results in decreased expression of IGFBP3 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP3 protein
Curcumin results in increased secretion of IGFBP3 protein
Curcumin results in increased expression of IGFBP3 mRNA

PMID:16101141 PMID:17499312 PMID:18299980 PMID:21594647 PMID:27430728

NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874

G

insulin like growth factor binding protein 4

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP4 mRNA]
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP4 protein

PMID:18200517 PMID:27430728

NCBI chr17:40,443,450...40,457,725
Ensembl chr17:40,443,450...40,457,725

G

insulin like growth factor binding protein 5

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP5 mRNA]
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP5 protein

PMID:18200517 PMID:27430728

NCBI chr 2:216,672,105...216,695,549
Ensembl chr 2:216,672,105...216,695,549

G

insulin like growth factor binding protein 7

increases expression

Curcumin results in increased expression of IGFBP7 mRNA

NCBI chr 4:57,030,773...57,110,385
Ensembl chr 4:57,030,773...57,110,385

G

immunoglobulin lambda like polypeptide 1

decreases expression

Curcumin results in decreased expression of IGLL1 mRNA

NCBI chr22:23,573,125...23,580,290
Ensembl chr22:23,573,125...23,580,302

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions
decreases activity

Curcumin inhibits the reaction [bisphenol A results in increased expression of IKBKB protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]; Curcumin inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]
Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]
Curcumin results in decreased activity of IKBKB protein

PMID:16023083 PMID:16219905 PMID:16678799 PMID:17965732 PMID:20054000 More...

NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKG mRNA]

NCBI chr X:154,541,238...154,565,046
Ensembl chr X:154,541,199...154,565,046

G

interleukin 10

multiple interactions
decreases expression

Curcumin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL10 mRNA]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IL10 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IL10 protein]
Curcumin results in decreased expression of IL10 protein
CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Methotrexate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]

PMID:15604057 PMID:16867261 PMID:17979888 PMID:20885979 PMID:21397623 More...

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 12A

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA]

NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019

G

interleukin 12B

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL12B mRNA]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL12B mRNA]

PMID:16867261 PMID:23452621

NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863

G

interleukin 17A

multiple interactions

Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL17A protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL17A mRNA]

PMID:34998855 PMID:35716765

NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638

G

interleukin 18

multiple interactions
decreases expression

Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of IL18 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased secretion of IL18 protein]
Curcumin results in decreased expression of IL18 mRNA
Curcumin results in decreased expression of IL18 mRNA; Curcumin results in decreased expression of IL18 protein

PMID:16368150 PMID:16751071 PMID:17399992 PMID:35063475

NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096

G

interleukin 1 alpha

multiple interactions

Curcumin inhibits the reaction [IL1A protein results in increased expression of TNFSF11 protein]
Curcumin inhibits the reaction [Soot results in increased secretion of IL1A protein]

PMID:18719352 PMID:19782127

NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493

G

interleukin 1 beta

affects expression
multiple interactions
decreases expression

Curcumin affects the expression of IL1B mRNA
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]; Curcumin inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGES protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of and results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL1B mRNA]
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [Chloranil results in increased expression of IL1B protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of IL1B protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL1B mRNA]
[Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of IL1B protein]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Soot results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IL1B protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]]

PMID:15604057 PMID:15793857 PMID:16751071 PMID:16782535 PMID:16819191 More...

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 2

multiple interactions

Curcumin results in decreased expression of and results in decreased secretion of IL2 protein

NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725

G

interleukin 2 receptor subunit alpha

multiple interactions

Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL2RA protein]

NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370

G

interleukin 4

multiple interactions
decreases expression

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 protein]
Curcumin results in decreased expression of IL4 protein

PMID:16782535 PMID:16867261 PMID:21397623

NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678

G

interleukin 5

multiple interactions

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL5 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL5 protein]

NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838

G

interleukin 6

multiple interactions
decreases expression
increases expression
affects expression

Curcumin inhibits the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Acids results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Acids results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL6 mRNA]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Chloranil results in increased expression of IL6 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin inhibits the reaction [sodium arsenite affects the expression of IL6 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL6 mRNA]
Curcumin results in increased expression of IL6 protein
Curcumin results in increased expression of IL6 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of IL6 protein]; [Zinc binds to Curcumin] inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of IL6 protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Soot results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]
Curcumin affects the expression of IL6 mRNA; Curcumin affects the expression of IL6 protein

PMID:16751071 PMID:17151092 PMID:17273796 PMID:17383825 PMID:17999991 More...

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

interleukin 6 receptor

multiple interactions

Curcumin inhibits the reaction [Trichloroethylene results in increased expression of IL6R protein]

NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450

G

interleukin 6 cytokine family signal transducer

multiple interactions

Curcumin inhibits the reaction [Trichloroethylene results in increased expression of IL6ST protein]

NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022

G

insulin

multiple interactions

Curcumin inhibits the reaction [Fructose results in increased expression of INS protein]
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]]

PMID:25268984 PMID:26713546 PMID:28595985

NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221

G

INS-IGF2 readthrough

multiple interactions

Curcumin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
Curcumin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]

PMID:23267840 PMID:25541178 PMID:27208389

NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209

G

insulin induced gene 2

multiple interactions

Curcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA]

NCBI chr 2:118,088,471...118,110,997
Ensembl chr 2:118,088,452...118,110,997

G

insulin receptor

multiple interactions

Curcumin inhibits the reaction [bisphenol A results in decreased expression of INSR protein modified form]

NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414

G

inositol 1,4,5-triphosphate receptor associated 2

decreases expression

Curcumin results in decreased expression of IRAG2 mRNA

NCBI chr12:24,997,575...25,108,335
Ensembl chr12:25,004,342...25,108,335

G

interleukin 1 receptor associated kinase 1

multiple interactions

Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA]

PMID:16678799 PMID:23452621

NCBI chr X:154,010,507...154,019,902
Ensembl chr X:154,010,506...154,019,902

G

interleukin 1 receptor associated kinase 2

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IRAK2 mRNA]

NCBI chr 3:10,164,919...10,243,745
Ensembl chr 3:10,164,919...10,243,745

G

interferon regulatory factor 3

multiple interactions

Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]

NCBI chr19:49,659,572...49,665,857
Ensembl chr19:49,659,569...49,665,875

G

interferon regulatory factor 5

increases expression

Curcumin analog results in increased expression of IRF5 mRNA

NCBI chr 7:128,937,032...128,950,038
Ensembl chr 7:128,937,457...128,950,038

G

insulin receptor substrate 1

multiple interactions
affects phosphorylation

Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein]
Curcumin inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form]
Curcumin affects the phosphorylation of IRS1 protein

PMID:26713546 PMID:27208389 PMID:29793316

NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820

G

insulin receptor substrate 2

affects phosphorylation

Curcumin affects the phosphorylation of IRS2 protein

NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583

G

integrin subunit alpha 2b

multiple interactions

Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]

NCBI chr17:44,372,181...44,389,649
Ensembl chr17:44,372,180...44,389,649

G

integrin subunit alpha M

multiple interactions
increases expression

Calcitriol promotes the reaction [Curcumin results in increased expression of ITGAM]; Tretinoin promotes the reaction [Curcumin results in increased expression of ITGAM]

NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892

G

integrin subunit beta 1

multiple interactions
increases expression

Curcumin inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]
Curcumin results in increased expression of ITGB1 protein

NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792

G

integrin subunit beta 3

multiple interactions

Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]

NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,827...47,313,743

G

integral membrane protein 2A

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ITM2A mRNA]

NCBI chr X:79,360,384...79,367,334
Ensembl chr X:79,360,384...79,367,667

G

involucrin

multiple interactions

Curcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCD protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IVL mRNA]

NCBI chr 1:152,908,546...152,911,886
Ensembl chr 1:152,908,546...152,911,886

G

Janus kinase 2

decreases expression
multiple interactions

Curcumin results in decreased expression of JAK2 protein
Arsenic Trioxide promotes the reaction [Curcumin results in decreased expression of JAK2 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased phosphorylation of JAK2 protein]

PMID:16959222 PMID:34233590 PMID:36352148

NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948

G

Janus kinase 3

decreases activity

Curcumin results in decreased activity of JAK3 protein

NCBI chr19:17,824,782...17,847,982
Ensembl chr19:17,824,780...17,848,071

G

junctional sarcoplasmic reticulum protein 1

decreases expression

Curcumin results in decreased expression of JSRP1 mRNA

NCBI chr19:2,252,252...2,256,417
Ensembl chr19:2,252,252...2,269,759

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases phosphorylation
multiple interactions
increases expression
decreases activity

Curcumin results in decreased phosphorylation of JUN protein
Curcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Curcumin inhibits the reaction [benzyl isothiocyanate results in increased expression of and results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of JUN mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of JUN protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN protein]
Curcumin inhibits the reaction [Bleomycin results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of JUN protein]
Curcumin results in increased expression of JUN mRNA
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Curcumin analog inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]
Curcumin results in decreased activity of JUN protein

PMID:11035063 PMID:15713895 PMID:17148446 PMID:17458902 PMID:17596214 More...

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases ubiquitination

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUNB protein]
Curcumin results in increased ubiquitination of JUNB protein

NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUND protein]

NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Curcumin results in decreased activity of KCNH2 protein

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

G

potassium calcium-activated channel subfamily M regulatory beta subunit 2

decreases expression

Curcumin results in decreased expression of KCNMB2 mRNA

NCBI chr 3:178,536,436...178,844,429
Ensembl chr 3:178,272,932...178,844,429

G

kinase insert domain receptor

affects expression
multiple interactions

Curcumin affects the expression of KDR mRNA
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR protein]
Curcumin inhibits the reaction [Dietary Fats results in increased expression of KDR mRNA]

PMID:17960570 PMID:19297423 PMID:23845850 PMID:35752269

NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595

G

kelch like ECH associated protein 1

multiple interactions
decreases expression
increases expression

Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 protein]; KEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]
Curcumin results in decreased expression of KEAP1 mRNA
Curcumin analog results in decreased expression of KEAP1 protein; Curcumin results in decreased expression of KEAP1 protein
Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 protein]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]
Curcumin results in increased expression of KEAP1 mRNA

PMID:17535857 PMID:23710286 PMID:26991801 PMID:30946834 PMID:31521693 More...

NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558

G

KIT proto-oncogene, receptor tyrosine kinase

multiple interactions

[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of KIT protein

NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783

G

KLF transcription factor 10

decreases expression

Curcumin results in decreased expression of KLF10 mRNA

NCBI chr 8:102,648,784...102,655,725
Ensembl chr 8:102,648,784...102,655,725

G

KLF transcription factor 6

increases expression

Curcumin results in increased expression of KLF6 mRNA

NCBI chr10:3,775,996...3,785,209
Ensembl chr10:3,775,996...3,785,281

G

kelch like family member 21

increases expression

Curcumin results in increased expression of KLHL21 mRNA

NCBI chr 1:6,590,724...6,602,869
Ensembl chr 1:6,590,724...6,614,607

G

kelch like family member 24

decreases expression

Curcumin results in decreased expression of KLHL24 mRNA

NCBI chr 3:183,635,623...183,684,519
Ensembl chr 3:183,635,610...183,684,519

G

kallikrein related peptidase 2

decreases expression
multiple interactions

Curcumin results in decreased expression of KLK2 mRNA
[Curcumin co-treated with Arsenic Trioxide] results in decreased expression of KLK2 mRNA

PMID:18719366 PMID:35487055

NCBI chr19:50,873,439...50,880,567
Ensembl chr19:50,861,568...50,880,567

G

kallikrein related peptidase 3

multiple interactions
decreases expression

Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 protein]; Curcumin inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Metribolone results in increased expression of KLK3 protein]; Curcumin results in decreased expression of and results in decreased secretion of KLK3 protein; trichostatin A inhibits the reaction [Curcumin results in decreased expression of KLK3 mRNA]
Curcumin results in decreased expression of KLK3 mRNA; Curcumin results in decreased expression of KLK3 protein

PMID:12497104 PMID:18676361 PMID:18719366 PMID:21134073 PMID:22258452

NCBI chr19:50,854,915...50,860,764
Ensembl chr19:50,854,915...50,860,764

G

lysine methyltransferase 5A

decreases expression

Curcumin results in decreased expression of KMT5A mRNA; Curcumin results in decreased expression of KMT5A protein

NCBI chr12:123,384,132...123,409,353
Ensembl chr12:123,384,132...123,409,353

G

KRAS proto-oncogene, GTPase

decreases expression
multiple interactions

Curcumin analog results in decreased expression of KRAS mRNA; Curcumin results in decreased expression of KRAS mRNA
Curcumin affects the reaction [KRAS protein affects the localization of TRP53 protein]; Curcumin inhibits the reaction [KRAS protein results in decreased expression of XPO1 protein]

PMID:17041101 PMID:21519798

NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936

G

keratin associated protein 2-1

decreases expression

Curcumin results in decreased expression of KRTAP2-1 mRNA

NCBI chr17:41,046,541...41,047,316
Ensembl chr17:41,046,541...41,047,316

G

kynureninase

increases expression

Curcumin results in increased expression of KYNU mRNA

NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833

G

lysosomal associated membrane protein 1

affects expression
multiple interactions

Curcumin affects the expression of LAMP1 mRNA
Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]]

PMID:18539377 PMID:34758851

NCBI chr13:113,297,239...113,323,672
Ensembl chr13:113,297,239...113,323,672

G

lipopolysaccharide binding protein

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LBP mRNA]

NCBI chr20:38,346,482...38,377,013
Ensembl chr20:38,346,482...38,377,013

G

lipocalin 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCN2 mRNA]
Curcumin inhibits the reaction [Cadmium Chloride results in increased export of LCN2 protein]; Curcumin inhibits the reaction [maleic acid results in increased secretion of LCN2 protein]

PMID:18200517 PMID:25119790 PMID:29421648

NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453

G

lymphocyte cytosolic protein 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCP1 mRNA]

NCBI chr13:46,125,923...46,182,177
Ensembl chr13:46,125,920...46,211,871

G

lymphocyte cytosolic protein 2

increases expression

Curcumin results in increased expression of LCP2 mRNA

NCBI chr 5:170,246,233...170,297,777
Ensembl chr 5:170,246,233...170,297,815

G

lactate dehydrogenase A

multiple interactions
decreases expression

ATF4 inhibits the reaction [Curcumin results in decreased expression of LDHA protein]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of LDHA protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of LDHA protein]

PMID:36640941 PMID:36924976

NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425

G

low density lipoprotein receptor

multiple interactions
affects expression
increases expression

Curcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA]; Curcumin results in increased expression of and results in increased activity of LDLR protein
Curcumin affects the expression of LDLR mRNA
Curcumin results in increased expression of LDLR mRNA; Curcumin results in increased expression of LDLR protein

PMID:16713233 PMID:16963807 PMID:18704882 PMID:27208389

NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820

G

lymphoid enhancer binding factor 1

increases expression
multiple interactions

Curcumin results in increased expression of LEF1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of LEF1 mRNA]

NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956

G

legumain

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LGMN mRNA]

NCBI chr14:92,703,809...92,748,627
Ensembl chr14:92,703,807...92,748,679

G

luteinizing hormone subunit beta

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of LHB protein]

NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091

G

LIM homeobox 5

affects expression

Curcumin affects the expression of LHX5 mRNA

NCBI chr12:113,462,033...113,471,871
Ensembl chr12:113,462,033...113,472,280

G

DNA ligase 3

multiple interactions

Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 protein]

NCBI chr17:34,980,512...35,010,872
Ensembl chr17:34,980,512...35,009,743

G

DNA ligase 4

multiple interactions

Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG4 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG4 protein]

NCBI chr13:108,207,442...108,218,349
Ensembl chr13:108,207,439...108,218,368

G

leukocyte immunoglobulin like receptor B3

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LILRB3 mRNA]

NCBI chr19:54,216,278...54,223,007
Ensembl chr19:54,216,278...54,223,506

G

lipase C, hepatic type

affects expression

Curcumin affects the expression of LIPC mRNA

NCBI chr15:58,431,991...58,569,844
Ensembl chr15:58,410,569...58,569,844

G

lysyl oxidase

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LOX mRNA]

NCBI chr 5:122,063,195...122,078,259
Ensembl chr 5:122,063,195...122,078,413

G

lysophosphatidic acid receptor 1

decreases expression

Curcumin results in decreased expression of LPAR1 mRNA

NCBI chr 9:110,873,263...111,038,998
Ensembl chr 9:110,873,263...111,038,470

G

lipoprotein lipase

affects expression

Curcumin affects the expression of LPL mRNA

NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259

G

LDL receptor related protein 5

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of LRP5 mRNA]
Curcumin results in increased expression of LRP5 mRNA

NCBI chr11:68,298,412...68,449,275
Ensembl chr11:68,312,591...68,449,275

G

LDL receptor related protein 6

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of LRP6 mRNA]
Curcumin results in increased expression of LRP6 mRNA

NCBI chr12:12,116,025...12,267,044
Ensembl chr12:12,116,025...12,267,044

G

leucine rich repeat neuronal 3

increases expression

Curcumin results in increased expression of LRRN3 mRNA

NCBI chr 7:111,091,127...111,125,454
Ensembl chr 7:111,091,006...111,125,454

G

lanosterol synthase

affects expression
decreases expression

Curcumin affects the expression of LSS mRNA
Curcumin results in decreased expression of LSS mRNA

NCBI chr21:46,188,446...46,228,774
Ensembl chr21:46,188,141...46,228,824

G

lymphotoxin alpha

decreases expression
multiple interactions
increases expression

Curcumin results in decreased expression of LTA mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of LTA protein
Curcumin results in increased expression of LTA mRNA

PMID:16101141 PMID:17198877 PMID:27430728

NCBI chr 6:31,560,610...31,574,324
Ensembl chr 6:31,572,054...31,574,324

G

lymphotoxin beta

increases expression
decreases expression

Curcumin results in increased expression of LTB mRNA
Curcumin results in decreased expression of LTB mRNA

PMID:16751071 PMID:17198877

NCBI chr 6:31,580,558...31,582,425
Ensembl chr 6:31,580,525...31,582,522

G

lymphotoxin beta receptor

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of LTBR mRNA]

NCBI chr12:6,375,160...6,391,566
Ensembl chr12:6,375,045...6,391,571

G

lysozyme

multiple interactions
affects expression

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LYZ mRNA]
Curcumin affects the expression of LYZ2 mRNA

PMID:18200517 PMID:18539377

NCBI chr12:69,348,381...69,354,234
Ensembl chr12:69,348,381...69,354,234

G

mucosal vascular addressin cell adhesion molecule 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MADCAM1 mRNA]

NCBI chr19:496,486...505,343
Ensembl chr19:489,176...505,343

G

monoamine oxidase A

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of MAOA mRNA]

NCBI chr X:43,655,006...43,746,817
Ensembl chr X:43,654,907...43,746,817

G

microtubule associated protein 1 light chain 3 beta

multiple interactions
decreases expression
increases expression
increases lipidation

3-methyladenine inhibits the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; Curcumin inhibits the reaction [4-phenylbutyric acid results in decreased expression of MAP1LC3B protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MAP1LC3B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of MAP1LC3B protein]; Sirolimus promotes the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; U 0126 inhibits the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]
Curcumin results in increased expression of MAP1LC3B mRNA

PMID:34634291 PMID:36640941

NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779

G

mitogen-activated protein kinase kinase 1

multiple interactions

MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K1 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]

NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656

G

mitogen-activated protein kinase kinase 2

multiple interactions

MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K2 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]

NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122

G

mitogen-activated protein kinase kinase 3

increases expression

Curcumin results in increased expression of MAP2K3 mRNA

NCBI chr17:21,284,711...21,315,240
Ensembl chr17:21,284,672...21,315,232

G

mitogen-activated protein kinase kinase 4

decreases expression
increases phosphorylation

Curcumin results in decreased expression of MAP2K4 mRNA
Curcumin increases phosphorylation of MAP2K4 protein in uterine cervix

CTD
RGD

PMID:15713895 PMID:25198898

NCBI chr17:12,020,877...12,143,828
Ensembl chr17:12,020,829...12,143,830

G

mitogen-activated protein kinase kinase kinase 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA]
Curcumin results in decreased expression of MAP3K1 mRNA

PMID:15713895 PMID:17148446 PMID:23452621

NCBI chr 5:56,815,549...56,896,152
Ensembl chr 5:56,815,549...56,896,152

G

mitogen-activated protein kinase kinase kinase 5

increases phosphorylation

Curcumin increases phosphorylation of MAP3K5 protein in uterine cervix

RGD

NCBI chr 6:136,557,046...136,793,091
Ensembl chr 6:136,557,046...136,793,097

G

mitogen-activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation
decreases expression
decreases activity

[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [Curcumin results in decreased activity of MAPK1 protein] which results in increased susceptibility to Cisplatin; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Acids results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Furazolidone results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin results in increased phosphorylation of and results in increased activity of MAPK1 protein; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]
Curcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; [piperlongumine co-treated with Curcumin] results in decreased activity of MAPK1 protein; Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein]
Curcumin results in decreased expression of MAPK1 protein

PMID:11035063 PMID:11981161 PMID:16934299 PMID:17372590 PMID:17535857 More...

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 10

multiple interactions

Curcumin analog inhibits the reaction [Rotenone results in increased phosphorylation of MAPK10 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK10 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK10 protein]

PMID:24952339 PMID:27535828 PMID:27966075

NCBI chr 4:86,010,405...86,594,074
Ensembl chr 4:85,990,007...86,594,625

G

mitogen-activated protein kinase 12

increases activity

Curcumin results in increased activity of MAPK12 protein

NCBI chr22:50,252,901...50,261,683
Ensembl chr22:50,245,450...50,261,716

G

mitogen-activated protein kinase 14

multiple interactions

Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK14 mRNA]; MAPK14 protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]

PMID:17151092 PMID:18357586 PMID:31521693

NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236

G

mitogen-activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation
decreases expression
decreases activity

[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; [Curcumin results in decreased activity of MAPK3 protein] which results in increased susceptibility to Cisplatin; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Acids results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin results in increased phosphorylation of and results in increased activity of MAPK3 protein; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK3 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of MAPK3 protein]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]
Curcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; [piperlongumine co-treated with Curcumin] results in decreased activity of MAPK3 protein; Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein]
Curcumin results in decreased expression of MAPK3 protein

PMID:11035063 PMID:11981161 PMID:16934299 PMID:17372590 PMID:17535857 More...

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation
decreases phosphorylation
increases expression

Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK8 mRNA]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]
Curcumin increases phosphorylation of MAPK8 protein in uterine cervix
Curcumin results in decreased phosphorylation of MAPK8 protein
Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK8 protein
Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Bleomycin results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]
Curcumin results in increased expression of MAPK8 mRNA
Curcumin results in increased phosphorylation of MAPK8 protein

CTD
RGD

PMID:11981161 PMID:16101141 PMID:16678799 PMID:16934299 PMID:17372590 More...

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 9

multiple interactions
decreases phosphorylation
increases phosphorylation

Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein]
Curcumin results in decreased phosphorylation of MAPK9 protein
Curcumin results in increased phosphorylation of MAPK9 protein
Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK9 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK9 protein

PMID:11981161 PMID:17372590 PMID:18316600 PMID:18321868 PMID:18332871 More...

NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099

G

microtubule associated protein tau

multiple interactions

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of MAPT mRNA]

NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression
multiple interactions

Curcumin results in decreased expression of MCL1 protein alternative form
[Curcumin co-treated with Arsenic Trioxide] results in decreased expression of MCL1 protein

PMID:18829502 PMID:34675983

NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738

G

minichromosome maintenance complex component 2

decreases expression

Curcumin results in decreased expression of MCM2 mRNA

NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,410...127,622,436

G

minichromosome maintenance complex component 7

decreases expression

Curcumin results in decreased expression of MCM7 mRNA

NCBI chr 7:100,092,728...100,101,397
Ensembl chr 7:100,092,233...100,101,940

G

MDM2 proto-oncogene

decreases expression
increases expression
multiple interactions

[Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of MDM2 mRNA; Curcumin results in decreased expression of MDM2 protein
Curcumin analog results in increased expression of MDM2 mRNA
Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of MDM2 protein]

PMID:17332326 PMID:24831732 PMID:26409325

NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544

G

methyl-CpG binding protein 2

decreases expression

Curcumin results in decreased expression of MECP2 protein

NCBI chr X:154,021,573...154,097,717
Ensembl chr X:154,021,573...154,137,103

G

myocyte enhancer factor 2C

decreases expression

Curcumin results in decreased expression of MEF2C mRNA

NCBI chr 5:88,717,117...88,904,105
Ensembl chr 5:88,717,117...88,904,257

G

melanotransferrin

decreases expression

Curcumin results in decreased expression of MELTF mRNA

NCBI chr 3:197,001,740...197,029,817
Ensembl chr 3:196,980,590...197,029,835

G

mitofusin 1

increases expression

Curcumin results in increased expression of MFN1 protein

NCBI chr 3:179,347,709...179,394,936
Ensembl chr 3:179,347,709...179,394,936

G

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

increases expression

Curcumin results in increased expression of MFNG mRNA

NCBI chr22:37,469,063...37,486,384
Ensembl chr22:37,469,063...37,486,393

G

O-6-methylguanine-DNA methyltransferase

decreases expression
increases expression
decreases activity
multiple interactions

Curcumin results in decreased expression of MGMT mRNA
Curcumin results in increased expression of MGMT mRNA
Curcumin results in decreased activity of MGMT protein
Curcumin results in increased expression of and results in increased activity of MGMT protein

PMID:16950796 PMID:17596214

NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983

G

microsomal glutathione S-transferase 1

increases expression

Curcumin results in increased expression of MGST1 mRNA

NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259

G

microRNA 125a

decreases expression
multiple interactions

Curcumin results in decreased expression of MIR125A mRNA
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of MIR125A mRNA]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]

PMID:29723631 PMID:33952798

NCBI chr19:51,693,254...51,693,339
Ensembl chr19:51,693,254...51,693,339

G

microRNA 1290

increases expression

Curcumin results in increased expression of MIR1290 mRNA

NCBI chr 1:18,897,071...18,897,148
Ensembl chr 1:18,897,071...18,897,148

G

microRNA 146a

multiple interactions

Curcumin inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA]

NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450

G

microRNA 19a

multiple interactions

Curcumin inhibits the reaction [bisphenol A results in increased expression of MIR19A mRNA]

NCBI chr13:91,350,891...91,350,972
Ensembl chr13:91,350,891...91,350,972

G

microRNA 21

decreases expression

Curcumin results in decreased expression of MIR21 mRNA

NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337

G

microRNA 22

increases expression

Curcumin results in increased expression of MIR22

NCBI chr17:1,713,903...1,713,987
Ensembl chr17:1,713,903...1,713,987

G

microRNA 222

decreases expression

Curcumin results in decreased expression of MIR222 mRNA

NCBI chr X:45,747,015...45,747,124
Ensembl chr X:45,747,015...45,747,124

G

microRNA 223

increases expression

Curcumin results in increased expression of MIR223 mRNA

NCBI chr X:66,018,870...66,018,979
Ensembl chr X:66,018,870...66,018,979

G

MIR22 host gene

increases expression

Curcumin results in increased expression of MIR22HG mRNA

NCBI chr17:1,711,504...1,716,272
Ensembl chr17:1,711,447...1,717,174

G

microRNA 27a

decreases expression

Curcumin results in decreased expression of MIR27A mRNA

NCBI chr19:13,836,440...13,836,517
Ensembl chr19:13,836,440...13,836,517

G

microRNA 27b

decreases expression

Curcumin results in decreased expression of MIR27B mRNA

NCBI chr 9:95,085,445...95,085,541
Ensembl chr 9:95,085,445...95,085,541

G

microRNA 30a

increases expression

Curcumin results in increased expression of MIR30A mRNA

NCBI chr 6:71,403,551...71,403,621
Ensembl chr 6:71,403,551...71,403,621

G

microRNA 34a

multiple interactions

Curcumin inhibits the reaction [Cyclosporine results in increased expression of MIR34A mRNA]

NCBI chr 1:9,151,668...9,151,777
Ensembl chr 1:9,151,668...9,151,777

G

microRNA 532

multiple interactions
increases expression

MIR532 affects the reaction [Curcumin results in decreased expression of AKT3 protein]; MIR532 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; NRIP1 mRNA alternative form inhibits the reaction [Curcumin results in increased expression of MIR532 mRNA]

NCBI chr X:50,003,148...50,003,238
Ensembl chr X:50,003,148...50,003,238

G

microRNA 802

multiple interactions

Curcumin inhibits the reaction [Acetaminophen results in increased expression of MIR802 mRNA]

NCBI chr21:35,720,715...35,720,808
Ensembl chr21:35,720,715...35,720,808

G

microRNA 99a

multiple interactions

Curcumin inhibits the reaction [benzyl isothiocyanate results in increased expression of MIR99A mRNA]

NCBI chr21:16,539,089...16,539,169
Ensembl chr21:16,539,089...16,539,169

G

marker of proliferation Ki-67

multiple interactions
decreases expression

[Curcumin co-treated with Gemcitabine] results in decreased expression of MKI67 protein
Curcumin results in decreased expression of MKI67 protein

PMID:17440100 PMID:18226269 PMID:19372569

NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423

G

membrane metalloendopeptidase

decreases expression

Curcumin results in decreased expression of MME mRNA

NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704

G

matrix metallopeptidase 1

multiple interactions

Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]

NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160

G

matrix metallopeptidase 10

increases expression

Curcumin results in increased expression of MMP10 mRNA

NCBI chr11:102,770,502...102,780,628
Ensembl chr11:102,770,502...102,780,628

G

matrix metallopeptidase 13

multiple interactions

Curcumin inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]

NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732

G

matrix metallopeptidase 14

decreases expression
multiple interactions

Curcumin results in decreased expression of MMP14 protein
Curcumin inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP14 mRNA]

PMID:16934674 PMID:18200517 PMID:18495463

NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,041

G

matrix metallopeptidase 2

multiple interactions
decreases expression
decreases activity
increases activity

Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of MMP2 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MMP2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP2 protein]; Curcumin results in decreased secretion of and results in decreased activity of MMP2 protein modified form; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP2 protein]
Curcumin results in decreased activity of MMP2 protein
Curcumin results in increased activity of MMP2 protein
Curcumin inhibits the reaction [Bleomycin results in increased expression of and results in increased secretion of MMP2 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of MMP2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP2 mRNA]
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]

PMID:16934674 PMID:17531121 PMID:17996675 PMID:18200517 PMID:18226269 More...

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 3

increases expression

Curcumin results in increased expression of MMP3 mRNA

PMID:15713895 PMID:18321735

NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609

G

matrix metallopeptidase 7

multiple interactions

Curcumin inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]; Curcumin inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA]

PMID:17928719 PMID:23452621

NCBI chr11:102,520,508...102,530,747
Ensembl chr11:102,520,508...102,530,750

G

matrix metallopeptidase 9

multiple interactions
decreases activity
decreases expression
increases activity
affects expression

3-caffeoyl-4-dihydrocaffeoylquinic acid promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Cadmium results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP9 protein]; Curcumin promotes the reaction [3-caffeoyl-4-dihydrocaffeoylquinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; Curcumin promotes the reaction [4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; Curcumin promotes the reaction [4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]]; Curcumin results in decreased secretion of and results in decreased activity of MMP9 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP9 protein]
Curcumin results in decreased activity of MMP9 protein
Curcumin results in increased activity of MMP9 protein
Curcumin affects the expression of MMP9 mRNA; Curcumin affects the expression of MMP9 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased activity of MMP9 protein]; [Zinc binds to Curcumin] inhibits the reaction [Acetic Acid results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [Ethanol results in increased expression of MMP9 mRNA]
[Curcumin co-treated with Gemcitabine] results in decreased expression of MMP9 protein; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of and results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of and results in increased secretion of MMP9 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of MMP9 mRNA]

PMID:16219905 PMID:16243823 PMID:17291458 PMID:17440100 PMID:17531121 More...

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

M-phase phosphoprotein 6

decreases expression

Curcumin results in decreased expression of MPHOSPH6 mRNA

NCBI chr16:82,148,162...82,170,224
Ensembl chr16:82,147,798...82,170,224

G

myeloperoxidase

multiple interactions
decreases activity

Curcumin inhibits the reaction [Dinitrochlorobenzene results in decreased activity of MPO protein]; Curcumin inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Curcumin inhibits the reaction [Methotrexate results in increased expression of MPO protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of MPO protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of MPO protein]]
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MPO protein]; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MPO protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of MPO protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MPO protein]
Curcumin analog results in decreased activity of MPO protein
Curcumin results in decreased activity of MPO protein

PMID:16804969 PMID:16867261 PMID:17276891 PMID:17351913 PMID:17373747 More...

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

G

mitochondrial ribosomal protein L1

increases expression

Curcumin results in increased expression of MRPL1 mRNA

NCBI chr 4:77,862,830...77,952,785
Ensembl chr 4:77,862,830...77,952,785

G

mitochondrial ribosomal protein L47

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of MRPL47 mRNA]

NCBI chr 3:179,588,285...179,604,646
Ensembl chr 3:179,588,285...179,604,649

G

membrane spanning 4-domains A1

decreases expression
increases expression

Curcumin results in decreased expression of MS4A1 mRNA
Curcumin results in increased expression of MS4A1 mRNA

PMID:17198877 PMID:18421014

NCBI chr11:60,455,847...60,470,752
Ensembl chr11:60,455,846...60,470,752

G

methylsterol monooxygenase 1

affects expression
decreases expression

Curcumin affects the expression of MSMO1 mRNA
Curcumin results in decreased expression of MSMO1 mRNA

NCBI chr 4:165,327,669...165,343,164
Ensembl chr 4:165,327,667...165,343,164

G

moesin

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MSN mRNA]

NCBI chr X:65,588,377...65,741,931
Ensembl chr X:65,588,377...65,741,931

G

macrophage scavenger receptor 1

multiple interactions

Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of MSR1 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]

NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490

G

macrophage stimulating 1 receptor

multiple interactions
decreases expression

Curcumin inhibits the reaction [RELA protein binds to MST1R promoter]; Curcumin inhibits the reaction [RELA protein results in increased expression of MST1R mRNA]
Curcumin results in decreased expression of MST1R mRNA; Curcumin results in decreased expression of MST1R protein

NCBI chr 3:49,887,002...49,903,873
Ensembl chr 3:49,887,002...49,903,873

G

metallothionein 1A

multiple interactions
increases expression

Curcumin affects the reaction [Mercuric Chloride results in increased expression of MT1A mRNA]
Curcumin results in increased expression of MT1A mRNA

NCBI chr16:56,638,666...56,640,087
Ensembl chr16:56,638,666...56,640,087

G

metallothionein 2A

multiple interactions
increases expression

Curcumin affects the reaction [Mercuric Chloride results in increased expression of MT2A mRNA]
Curcumin results in increased expression of MT2A mRNA

NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497

G

mechanistic target of rapamycin kinase

decreases phosphorylation
multiple interactions
decreases expression

Curcumin results in decreased phosphorylation of MTOR protein
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of MTOR protein]
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of and results in increased phosphorylation of MTOR protein]; Curcumin promotes the reaction [Sirolimus results in decreased phosphorylation of MTOR protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of MTOR protein
Curcumin analog results in decreased expression of MTOR mRNA; Curcumin results in decreased expression of MTOR mRNA

PMID:20554536 PMID:21450334 PMID:26409325 PMID:27363783 PMID:33582110 More...

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

Curcumin inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]

NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138

G

mevalonate diphosphate decarboxylase

decreases expression

Curcumin results in decreased expression of MVD mRNA

NCBI chr16:88,651,940...88,663,091
Ensembl chr16:88,651,935...88,663,161

G

mevalonate kinase

affects expression
decreases expression

Curcumin affects the expression of MVK mRNA
Curcumin results in decreased expression of MVK mRNA

NCBI chr12:109,573,272...109,598,125
Ensembl chr12:109,573,255...109,598,125

G

MAX dimerization protein 1

increases expression

Curcumin results in increased expression of MXD1 mRNA

NCBI chr 2:69,915,109...69,942,945
Ensembl chr 2:69,897,688...69,942,945

G

MAX dimerization protein 3

decreases expression

Curcumin results in decreased expression of MXD3 mRNA

PMID:15713895 PMID:17198877

NCBI chr 5:177,305,499...177,312,752
Ensembl chr 5:177,301,461...177,312,757

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
increases expression
decreases expression

[Curcumin co-treated with Doxorubicin] affects the expression of MYC mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of MYC protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MYC mRNA]
[Curcumin co-treated with Gemcitabine] results in decreased expression of MYC protein
Curcumin results in increased expression of MYC mRNA
Curcumin analog results in decreased expression of MYC protein; Curcumin results in decreased expression of MYC mRNA; Curcumin results in decreased expression of MYC protein

PMID:15713895 PMID:15911101 PMID:16219905 PMID:16243823 PMID:17041101 More...

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

MYD88 innate immune signal transduction adaptor

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]
Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of MYD88 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein]

PMID:19002562 PMID:23452621 PMID:34719837

NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024

G

myosin heavy chain 1

decreases expression

Curcumin results in decreased expression of MYH1 mRNA

NCBI chr17:10,492,307...10,518,542
Ensembl chr17:10,492,307...10,518,542

G

myosin heavy chain 6

decreases expression

Curcumin results in decreased expression of MYH6 mRNA

NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273

G

myosin heavy chain 7

multiple interactions
decreases expression

carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of MYH7 mRNA]; Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]

PMID:25093688 PMID:26612707

NCBI chr14:23,412,740...23,435,660
Ensembl chr14:23,412,740...23,435,660

G

myosin light chain 12A

increases expression

Curcumin results in increased expression of MYL12A mRNA

NCBI chr18:3,247,482...3,256,237
Ensembl chr18:3,247,481...3,256,236

G

myosin light chain 4

decreases expression

Curcumin results in decreased expression of MYL4 mRNA

NCBI chr17:47,189,433...47,227,650
Ensembl chr17:47,200,446...47,223,679

G

myosin light chain 9

multiple interactions

Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYL9 protein modified form]

NCBI chr20:36,541,519...36,551,447
Ensembl chr20:36,541,497...36,551,447

G

myosin light chain kinase

increases expression
multiple interactions

Curcumin results in increased expression of MYLK mRNA
Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYLK mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYLK protein]

PMID:21594647 PMID:35817260

NCBI chr 3:123,610,049...123,884,332
Ensembl chr 3:123,610,049...123,884,332

G

myosin XVIIIA

increases expression

Curcumin results in increased expression of MYO18A mRNA

NCBI chr17:29,071,122...29,180,398
Ensembl chr17:29,071,122...29,180,398

G

NLR family apoptosis inhibitory protein

multiple interactions
decreases expression

[Curcumin co-treated with Doxorubicin] affects the expression of NAIP mRNA; [Curcumin co-treated with Oxygen deficiency] results in decreased expression of NAIP protein
Curcumin analog results in decreased expression of NAIP mRNA; Curcumin results in decreased expression of NAIP mRNA

PMID:15911101 PMID:17671737 PMID:19250217 PMID:23452621

NCBI chr 5:70,968,166...71,025,339
Ensembl chr 5:70,968,166...71,025,339

G

Nanog homeobox

multiple interactions
increases expression

2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of NANOG mRNA]
Curcumin results in increased expression of NANOG mRNA; Curcumin results in increased expression of NANOG protein

PMID:25822711 PMID:27237783

NCBI chr12:7,789,402...7,799,146
Ensembl chr12:7,787,794...7,799,146

G

nanos C2HC-type zinc finger 1

decreases expression

Curcumin results in decreased expression of NANOS1 mRNA

NCBI chr10:119,029,714...119,033,730
Ensembl chr10:119,029,714...119,033,730

G

neural cell adhesion molecule 1

increases expression

Curcumin results in increased expression of NCAM1 protein modified form

NCBI chr11:112,961,420...113,278,436
Ensembl chr11:112,961,275...113,278,436

G

nuclear receptor coactivator 1

multiple interactions

Curcumin promotes the reaction [VDR protein binds to NCOA1 protein]

NCBI chr 2:24,491,254...24,770,702
Ensembl chr 2:24,491,254...24,770,702

G

neurofilament medium chain

increases expression

Curcumin results in increased expression of NEFM mRNA

NCBI chr 8:24,913,761...24,919,093
Ensembl chr 8:24,913,758...24,919,098

G

nei like DNA glycosylase 1

multiple interactions

Curcumin inhibits the reaction [Copper binds to and results in decreased activity of NEIL1 protein]; Curcumin inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein]

NCBI chr15:75,347,039...75,357,115
Ensembl chr15:75,346,955...75,357,115

G

nestin

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of NES mRNA]
Curcumin results in increased expression of NES mRNA

NCBI chr 1:156,668,763...156,677,407
Ensembl chr 1:156,668,763...156,677,407

G

neuronal differentiation 1

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of NEUROD1 mRNA]
Curcumin results in increased expression of NEUROD1 mRNA

NCBI chr 2:181,668,295...181,680,517
Ensembl chr 2:181,668,295...181,680,827

G

neurogenin 1

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of NEUROG1 mRNA]
Curcumin results in increased expression of NEUROG1 mRNA

NCBI chr 5:135,534,282...135,535,964
Ensembl chr 5:135,534,282...135,535,964

G

NFE2 like bZIP transcription factor 1

increases expression

Curcumin results in increased expression of NFE2L1 protein

NCBI chr17:48,048,359...48,061,545
Ensembl chr17:48,048,329...48,061,545

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression
increases activity
decreases response to substance
decreases methylation
affects localization
increases localization

[Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; Curcumin inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 protein]]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]; Curcumin promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [NFE2L2 protein binds to GSTP1 promoter]; Curcumin promotes the reaction [NFE2L2 protein results in increased expression of GSTP1 mRNA]; Curcumin promotes the reaction [quinocetone results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; Curcumin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [[Curcumin co-treated with sodium arsenite] promotes the reaction TFEB protein]; NFE2L2 protein affects the reaction [Curcumin analog results in decreased susceptibility to Acrolein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]]; NFE2L2 protein affects the reaction [Curcumin results in decreased susceptibility to Acrolein]
Curcumin results in increased expression of NFE2L2 mRNA; Curcumin results in increased expression of NFE2L2 protein
Curcumin analog results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 mRNA; Curcumin results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 protein modified form
Curcumin results in increased activity of NFE2L2 protein
NFE2L2 gene mutant form results in decreased susceptibility to Curcumin
Curcumin analog results in decreased methylation of NFE2L2 promoter
Curcumin affects the localization of NFE2L2 protein; Curcumin analog affects the localization of NFE2L2 protein
Curcumin results in increased localization of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; [Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [decamethrin results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 protein modified form]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [maleic acid affects the expression of NFE2L2 protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of NFE2L2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Streptozocin affects the localization of NFE2L2 protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]; Curcumin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [Curcumin results in increased activity of RELA protein]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 mRNA]]; pyrazolanthrone inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]
Curcumin analog results in increased expression of NFE2L2 mRNA; Curcumin analog results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 mRNA; Curcumin results in increased expression of NFE2L2 protein
[Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; [Curcumin co-treated with Benzo(a)pyrene] affects the localization of NFE2L2 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NFE2L2 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form affects the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL1B mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL6 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of TNF mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]

PMID:17449203 PMID:17535857 PMID:17640564 PMID:18006204 PMID:18321868 More...

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nuclear factor kappa B subunit 1

multiple interactions
decreases activity
decreases expression
decreases localization

Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]; Curcumin inhibits the reaction [Oxygen deficiency affects the localization of NFKB1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased activity of NFKB1 protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Curcumin results in decreased activity of [NFKB1 protein binds to RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]
Curcumin analog results in decreased activity of NFKB1 protein; Curcumin results in decreased activity of NFKB1 protein
[Zinc binds to Curcumin] which affects the expression of NFKB1 mRNA; Curcumin inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]]
Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Curcumin inhibits the reaction [NFKB1 protein binds to RELA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of NFKB1 mRNA]
Curcumin results in decreased expression of NFKB1 protein
Curcumin results in decreased localization of NFKB1 protein

PMID:15489888 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 More...

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

nuclear factor kappa B subunit 2

decreases activity

Curcumin results in decreased activity of NFKB2 protein

NCBI chr10:102,394,110...102,402,529
Ensembl chr10:102,394,110...102,402,524

G

NFKB inhibitor alpha

multiple interactions
decreases phosphorylation
increases expression
decreases expression

Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of NFKBIA protein modified form]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [NFKBIA protein results in increased degradation of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Paclitaxel results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Sodium Fluoride results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]; NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]
Curcumin inhibits the reaction [Fluorouracil results in decreased expression of NFKBIA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of NFKBIA protein]
Curcumin results in decreased phosphorylation of NFKBIA protein
Curcumin results in increased expression of NFKBIA protein
CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Fructose results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased degradation of NFKBIA protein]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
Curcumin results in decreased expression of NFKBIA protein

PMID:12216086 PMID:15489888 PMID:15793857 PMID:16023083 PMID:16219905 More...

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

NFKB inhibitor beta

multiple interactions

Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]

NCBI chr19:38,899,666...38,908,889
Ensembl chr19:38,899,700...38,908,893

G

nuclear transcription factor Y subunit alpha

decreases expression

Curcumin results in decreased expression of NFYA mRNA

NCBI chr 6:41,072,974...41,102,403
Ensembl chr 6:41,072,974...41,102,403

G

nerve growth factor receptor

decreases expression

Curcumin results in decreased expression of NGFR mRNA

NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008

G

NHL repeat containing 2

decreases expression

Curcumin results in decreased expression of NHLRC2 mRNA

NCBI chr10:113,854,661...113,917,194
Ensembl chr10:113,854,661...113,917,194

G

NK2 homeobox 5

decreases expression

Curcumin results in decreased expression of NKX2-5 mRNA

NCBI chr 5:173,232,109...173,235,206
Ensembl chr 5:173,232,109...173,235,311

G

NK3 homeobox 1

decreases expression

Curcumin results in decreased expression of NKX3-1 mRNA; Curcumin results in decreased expression of NKX3-1 protein

PMID:17303007 PMID:18719366

NCBI chr 8:23,678,693...23,682,938
Ensembl chr 8:23,678,697...23,682,938

G

NLR family pyrin domain containing 12

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA]

NCBI chr19:53,793,584...53,824,403
Ensembl chr19:53,793,741...53,824,403

G

NLR family pyrin domain containing 3

multiple interactions

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of NLRP3 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of NLRP3 protein]

PMID:34998855 PMID:35063475

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108

G

NME/NM23 nucleoside diphosphate kinase 1

increases expression

Curcumin results in increased expression of NME1 mRNA

NCBI chr17:51,153,559...51,162,168
Ensembl chr17:51,153,559...51,162,428

G

N-myristoyltransferase 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NMT2 mRNA]

NCBI chr10:15,105,700...15,168,693
Ensembl chr10:15,102,584...15,168,693

G

nucleotide binding oligomerization domain containing 1

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]

NCBI chr 7:30,424,527...30,478,784
Ensembl chr 7:30,424,527...30,478,784

G

nucleotide binding oligomerization domain containing 2

multiple interactions

Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine promotes the reaction [NOD2 protein binds to NOD2 protein]]; Curcumin inhibits the reaction [lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein]]

NCBI chr16:50,693,606...50,733,075
Ensembl chr16:50,693,588...50,733,077

G

nitric oxide synthase 1

multiple interactions

Curcumin inhibits the reaction [Cadmium Chloride results in decreased expression of NOS1 protein]
Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of NOS1 mRNA]

PMID:17627722 PMID:24662163

NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170

G

nitric oxide synthase 2

multiple interactions
decreases activity
affects expression
affects activity

Curcumin inhibits the reaction [Paraquat results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [quinocetone results in increased activity of NOS2 protein]; Curcumin inhibits the reaction [quinocetone results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]
Curcumin results in decreased activity of NOS2 protein
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Dinitrochlorobenzene results in decreased expression of NOS2 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Sodium Selenite results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Sodium Selenite results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]]
Curcumin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Chloranil results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]]
Curcumin affects the expression of NOS2 mRNA
Curcumin affects the activity of NOS2 protein

PMID:7530002 PMID:12628514 PMID:16934299 PMID:17373747 PMID:17434272 More...

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

nitric oxide synthase 3

multiple interactions

Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein]

PMID:18660423 PMID:23452621

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

G

notch receptor 1

decreases expression
multiple interactions

Curcumin results in decreased expression of NOTCH1 mRNA; Curcumin results in decreased expression of NOTCH1 protein
[Curcumin co-treated with Isoflavones] results in decreased expression of NOTCH1 protein

PMID:17927689 PMID:18640131

NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048

G

NADPH oxidase 4

multiple interactions

Curcumin inhibits the reaction [Cyclosporine results in increased expression of NOX4 protein]

NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187

G

NPC1 like intracellular cholesterol transporter 1

multiple interactions

Curcumin inhibits the reaction [bisphenol A results in increased expression of NPC1L1 protein]

NCBI chr 7:44,512,535...44,541,330
Ensembl chr 7:44,512,535...44,541,330

G

NPC intracellular cholesterol transporter 2

decreases expression

Curcumin results in decreased expression of NPC2 mRNA

NCBI chr14:74,479,935...74,493,512
Ensembl chr14:74,476,192...74,494,177

G

natriuretic peptide A

multiple interactions
decreases expression

carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of NPPA mRNA]

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

G

NAD(P)H quinone dehydrogenase 1

increases expression
increases activity
multiple interactions

Curcumin results in increased expression of NQO1 mRNA; Curcumin results in increased expression of NQO1 protein
Curcumin results in increased activity of NQO1 protein
Curcumin analog results in increased expression of NQO1 mRNA; Curcumin analog results in increased expression of NQO1 protein; Curcumin results in increased expression of NQO1 mRNA; Curcumin results in increased expression of NQO1 protein
Curcumin analog inhibits the reaction [Rotenone results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NQO1 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NQO1 protein]; Curcumin inhibits the reaction [Paraquat results in increased activity of NQO1 protein]
[Curcumin co-treated with Chloranil] results in increased expression of NQO1 protein; Curcumin affects the expression of and results in increased activity of NQO1 protein; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NQO1 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]

PMID:12628514 PMID:17198877 PMID:17535857 PMID:18299980 PMID:18321868 More...

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

nuclear receptor subfamily 1 group H member 3

increases expression
multiple interactions

Curcumin results in increased expression of NR1H3 mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of NR1H3 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of NR1H3 protein]
[Curcumin cotreated with oxidized LDL] increases expression of Nr1h3 protein in macrophages

CTD
RGD

PMID:16713233 PMID:37701206 PMID:25064633

NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033

G

nuclear receptor subfamily 1 group I member 2

increases activity
affects expression

Curcumin results in increased activity of NR1I2 protein
Curcumin affects the expression of NR1I2 mRNA

PMID:17210444 PMID:29933105

NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487

G

nuclear receptor subfamily 3 group C member 1

increases expression
multiple interactions

Curcumin results in increased expression of NR3C1 mRNA
Curcumin inhibits the reaction [Dexamethasone results in increased phosphorylation of NR3C1 protein]

PMID:17022948 PMID:18483179

NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512

G

nuclear receptor subfamily 4 group A member 2

decreases expression

Curcumin results in decreased expression of NR4A2 mRNA

NCBI chr 2:156,324,437...156,332,721
Ensembl chr 2:156,324,437...156,342,348

G

nuclear receptor interacting protein 1

decreases expression
multiple interactions

Curcumin results in decreased expression of NRIP1 mRNA alternative form
NRIP1 mRNA alternative form inhibits the reaction [Curcumin results in increased expression of MIR532 mRNA]

NCBI chr21:14,961,235...15,065,936
Ensembl chr21:14,961,235...15,065,936

G

netrin 1

multiple interactions

Curcumin inhibits the reaction [Cadmium Chloride results in increased export of NTN1 protein]

NCBI chr17:9,003,087...9,244,000
Ensembl chr17:9,021,510...9,244,000

G

neurotrophic receptor tyrosine kinase 2

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of NTRK2 protein]

NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751

G

nucleoporin 98 and 96 precursor

increases expression

Curcumin results in increased expression of NUP98 mRNA

NCBI chr11:3,675,010...3,797,554
Ensembl chr11:3,671,083...3,797,792

G

ornithine aminotransferase

affects expression

Curcumin affects the expression of OAT mRNA

NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976

G

occludin

multiple interactions

Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of OCLN mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of OCLN protein]

NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104

G

ornithine decarboxylase 1

increases expression
multiple interactions

Curcumin results in increased expression of ODC1 mRNA
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]

PMID:12628514 PMID:17198877

NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327

G

8-oxoguanine DNA glycosylase

multiple interactions

Curcumin inhibits the reaction [Arsenic results in increased expression of OGG1 mRNA]; Curcumin inhibits the reaction [Arsenic results in increased expression of OGG1 protein]

NCBI chr 3:9,749,952...9,783,108
Ensembl chr 3:9,749,944...9,788,219

G

oxidized low density lipoprotein receptor 1

multiple interactions

Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OLR1 mRNA]

NCBI chr12:10,158,301...10,176,266
Ensembl chr12:10,158,301...10,172,138

G

OPA1 mitochondrial dynamin like GTPase

multiple interactions

Curcumin inhibits the reaction [Cisplatin results in decreased expression of OPA1 protein]

NCBI chr 3:193,593,208...193,697,811
Ensembl chr 3:193,593,144...193,697,811

G

oncostatin M receptor

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OSMR mRNA]

NCBI chr 5:38,846,012...38,945,579
Ensembl chr 5:38,845,858...38,945,596

G

OTU deubiquitinase 7B

decreases expression

Curcumin results in decreased expression of OTUD7B mRNA

NCBI chr 1:149,937,812...150,067,653
Ensembl chr 1:149,937,812...150,010,726

G

phenylalanine hydroxylase

decreases expression

Curcumin results in decreased expression of PAH mRNA

NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410

G

p21 (RAC1) activated kinase 2

decreases cleavage

Curcumin results in decreased cleavage of PAK2 protein

NCBI chr 3:196,739,857...196,832,647
Ensembl chr 3:196,739,857...196,832,647

G

poly(ADP-ribose) polymerase 1

multiple interactions
increases expression
decreases cleavage
decreases expression
increases cleavage
increases degradation

[Curcumin co-treated with Bortezomib] results in increased cleavage of PARP1 protein; [Curcumin co-treated with Thalidomide] results in increased cleavage of PARP1 protein; arsenic trioxide promotes the reaction [Curcumin results in increased expression of PARP1 protein modified form]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PARP1 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PARP1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of PARP1 protein]; Curcumin inhibits the reaction [docetaxel results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]; Curcumin promotes the reaction [arsenic trioxide results in increased expression of PARP1 protein modified form]; Curcumin promotes the reaction [arsenite results in increased expression of PARP1 protein]; Curcumin results in increased cleavage of and results in increased activity of PARP1 protein
Curcumin results in decreased cleavage of PARP1 protein
Curcumin analog results in decreased expression of PARP1 mRNA
Curcumin results in increased cleavage of PARP1 protein
carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]
[Doxorubicin co-treated with Curcumin] results in increased cleavage of PARP1 protein; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
Curcumin results in increased degradation of PARP1

PMID:11035063 PMID:14555224 PMID:14724571 PMID:15569404 PMID:16023083 More...

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

paired box 6

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of PAX6 mRNA]
Curcumin results in increased expression of PAX6 mRNA

NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961

G

phosphoenolpyruvate carboxykinase 1

decreases expression
affects expression

Curcumin results in decreased expression of PCK1 mRNA
Curcumin affects the expression of PCK1 mRNA

PMID:17198877 PMID:27208389

NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121

G

proliferating cell nuclear antigen

decreases expression
multiple interactions
increases expression

Curcumin results in decreased expression of PCNA protein
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of PCNA protein
[Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of PCNA protein; Curcumin inhibits the reaction [bisphenol A results in increased expression of PCNA protein]
Curcumin results in increased expression of PCNA mRNA

PMID:16101141 PMID:18226269 PMID:23222814 PMID:24831732 PMID:26612707 More...

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

G

proprotein convertase subtilisin/kexin type 9

affects expression

Curcumin affects the expression of PCSK9 mRNA

NCBI chr 1:55,039,548...55,064,852
Ensembl chr 1:55,039,447...55,064,852

G

platelet derived growth factor subunit B

multiple interactions

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]

PMID:18006644 PMID:18784349

NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982

G

platelet derived growth factor receptor beta

increases expression
decreases phosphorylation
multiple interactions
decreases expression

Curcumin results in increased expression of PDGFRB mRNA
Curcumin results in decreased phosphorylation of PDGFRB protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]
Curcumin results in decreased expression of PDGFRB mRNA; Curcumin results in decreased expression of PDGFRB protein

PMID:17372590 PMID:18006644 PMID:18332871 PMID:21594647

NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872

G

protein disulfide isomerase family A member 3

increases expression

Curcumin results in increased expression of PDIA3 mRNA

NCBI chr15:43,746,438...43,773,278
Ensembl chr15:43,746,394...43,773,279

G

pyruvate dehydrogenase kinase 1

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PDK1 protein]; Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein]

NCBI chr 2:172,555,373...172,724,312
Ensembl chr 2:172,555,373...172,608,669

G

3-phosphoinositide dependent protein kinase 1

decreases phosphorylation

Curcumin results in decreased phosphorylation of PDPK1 protein

NCBI chr16:2,538,021...2,603,188
Ensembl chr16:2,537,979...2,603,188

G

podoplanin

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PDPN mRNA]

NCBI chr 1:13,583,757...13,617,957
Ensembl chr 1:13,583,465...13,617,957

G

platelet and endothelial cell adhesion molecule 1

affects expression
multiple interactions
increases expression
decreases expression

Curcumin affects the expression of PECAM1 protein
Curcumin inhibits the reaction [Particulate Matter results in increased expression of PECAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of PECAM1 protein]
Curcumin results in increased expression of PECAM1 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 protein]
Gemcitabine promotes the reaction [Curcumin results in decreased expression of PECAM1 protein]

PMID:17440100 PMID:17960570 PMID:23845850 PMID:29244817

NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776

G

period circadian regulator 2

increases expression

Curcumin results in increased expression of PER2 mRNA

NCBI chr 2:238,244,044...238,300,065
Ensembl chr 2:238,244,044...238,290,102

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

decreases expression

Curcumin results in decreased expression of PFKFB4 mRNA

NCBI chr 3:48,517,684...48,563,136
Ensembl chr 3:48,517,684...48,562,015

G

phosphogluconate dehydrogenase

increases expression

Curcumin results in increased expression of PGD mRNA

NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511

G

placental growth factor

multiple interactions

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PGF mRNA]

NCBI chr14:74,941,830...74,955,764
Ensembl chr14:74,941,834...74,955,626

G

phosphatidylglycerophosphate synthase 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PGS1 mRNA]

NCBI chr17:78,378,649...78,424,659
Ensembl chr17:78,378,649...78,425,114

G

prohibitin 1

decreases expression

Curcumin results in decreased expression of PHB1 protein

NCBI chr17:49,404,052...49,414,882
Ensembl chr17:49,404,049...49,414,905

G

phytanoyl-CoA 2-hydroxylase

decreases expression

Curcumin results in decreased expression of PHYH mRNA

NCBI chr10:13,277,799...13,300,064
Ensembl chr10:13,277,796...13,302,412

G

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

decreases expression

Curcumin analog results in decreased expression of PIK3C2A mRNA

NCBI chr11:17,086,575...17,207,986
Ensembl chr11:17,077,730...17,207,986

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

decreases expression

Curcumin analog results in decreased expression of PIK3CA mRNA

NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093

G

PTEN induced kinase 1

multiple interactions

Curcumin inhibits the reaction [Cisplatin results in increased expression of PINK1 protein]

NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511

G

pirin

increases expression

Curcumin results in increased expression of PIR mRNA

NCBI chr X:15,384,799...15,493,333
Ensembl chr X:15,384,799...15,493,564

G

pyruvate kinase M1/2

multiple interactions

ATF4 inhibits the reaction [Curcumin results in decreased expression of PKM protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of PKM protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of PKM protein]

NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819

G

phospholipase A2 group IIA

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PLA2G2A mRNA]

NCBI chr 1:19,975,431...19,980,434
Ensembl chr 1:19,975,431...19,980,416

G

plasminogen activator, urokinase

decreases secretion
multiple interactions
increases expression
decreases expression

Curcumin results in decreased secretion of PLAU protein
Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAU mRNA]; Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAU protein]
Curcumin results in increased expression of PLAU mRNA
TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PLAU protein]

PMID:18025290 PMID:18226269 PMID:18495463 PMID:35716765

NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496

G

plasminogen activator, urokinase receptor

increases expression
multiple interactions

Curcumin results in increased expression of PLAUR mRNA
Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAUR mRNA]; Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAUR protein]

PMID:15713895 PMID:35716765

NCBI chr19:43,646,095...43,670,169
Ensembl chr19:43,646,095...43,670,547

G

phospholipase C gamma 1

multiple interactions

curcumin inhibits the reaction [azoxymethane increases activity of Plcg1 protein in colonic mucosa]

RGD

NCBI chr20:41,137,543...41,177,626
Ensembl chr20:41,136,960...41,196,801

G

pleckstrin homology, MyTH4 and FERM domain containing H2

increases expression

Curcumin results in increased expression of PLEKHH2 mRNA

NCBI chr 2:43,637,260...43,767,987
Ensembl chr 2:43,637,260...43,767,987

G

polo like kinase 1

decreases expression

Curcumin analog results in decreased expression of PLK1 mRNA

NCBI chr16:23,678,889...23,690,367
Ensembl chr16:23,677,656...23,690,367

G

polo like kinase 2

increases expression

Curcumin analog results in increased expression of PLK2 mRNA

NCBI chr 5:58,453,982...58,460,086
Ensembl chr 5:58,453,982...58,460,139

G

polo like kinase 3

increases expression

Curcumin analog results in increased expression of PLK3 mRNA

NCBI chr 1:44,800,377...44,805,990
Ensembl chr 1:44,800,377...44,805,990

G

polo like kinase 4

increases expression

Curcumin analog results in increased expression of PLK4 mRNA

NCBI chr 4:127,880,893...127,899,224
Ensembl chr 4:127,880,893...127,899,224

G

procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PLOD2 mRNA]

NCBI chr 3:146,069,440...146,161,184
Ensembl chr 3:146,035,139...146,163,725

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

Curcumin results in increased expression of PMAIP1 mRNA

NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,996...59,904,305

G

prostate transmembrane protein, androgen induced 1

decreases expression

Curcumin results in decreased expression of PMEPA1 mRNA

NCBI chr20:57,648,396...57,711,472
Ensembl chr20:57,648,392...57,711,536

G

DNA polymerase alpha 2, accessory subunit

decreases expression

Curcumin results in decreased expression of POLA2 mRNA

NCBI chr11:65,261,962...65,305,985
Ensembl chr11:65,261,913...65,305,959

G

DNA polymerase beta

multiple interactions
decreases expression

Curcumin inhibits the reaction [Arsenic results in decreased expression of POLB mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of POLB protein]
Curcumin results in decreased expression of POLB protein

PMID:19401701 PMID:21332098

NCBI chr 8:42,338,494...42,371,808
Ensembl chr 8:42,338,454...42,371,808

G

DNA polymerase epsilon, catalytic subunit

decreases expression

Curcumin results in decreased expression of POLE mRNA

NCBI chr12:132,623,762...132,687,342
Ensembl chr12:132,623,753...132,687,376

G

porcupine O-acyltransferase

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of PORCN mRNA]
Curcumin results in increased expression of PORCN mRNA

NCBI chr X:48,508,992...48,520,814
Ensembl chr X:48,508,959...48,520,814

G

periostin

increases expression

Curcumin results in increased expression of POSTN mRNA

NCBI chr13:37,562,585...37,598,768
Ensembl chr13:37,562,583...37,598,844

G

POU class 5 homeobox 1

multiple interactions
decreases expression
increases expression

2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of POU5F1 mRNA]
WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 protein]
Curcumin results in decreased expression of POU5F1 mRNA; Curcumin results in decreased expression of POU5F1 protein
Curcumin results in increased expression of POU5F1 mRNA; Curcumin results in increased expression of POU5F1 protein

PMID:25822711 PMID:27237783 PMID:33539684

NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731

G

peroxisome proliferator activated receptor delta

decreases expression

Curcumin results in decreased expression of PPARD mRNA; Curcumin results in decreased expression of PPARD protein

NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191

G

peroxisome proliferator activated receptor gamma

affects binding
decreases expression
increases expression
increases activity
affects localization
multiple interactions

Curcumin binds to PPARG protein
Curcumin results in decreased expression of PPARG mRNA
Curcumin results in increased expression of PPARG mRNA; Curcumin results in increased expression of PPARG protein
Curcumin results in increased activity of PPARG protein
Curcumin results in decreased expression of PPARG protein
Curcumin affects the localization of PPARG protein
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]; Curcumin results in decreased expression of and results in decreased activity of PPARG protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in decreased activity of PPARG protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of PPARG mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of PPARG protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG protein]; Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in decreased activity of PPARG protein]; Curcumin inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG protein]
PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA]
Curcumin results in decreased expression of PPARG protein modified form

PMID:15486348 PMID:15713005 PMID:16782535 PMID:16959952 PMID:17372590 More...

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

PPARG coactivator 1 alpha

multiple interactions
increases expression

Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A protein]; Curcumin inhibits the reaction [Potassium Dichromate results in decreased expression of PPARGC1A protein]
Curcumin results in increased expression of PPARGC1A protein

PMID:28951138 PMID:32980475

NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089

G

pancreatic progenitor cell differentiation and proliferation factor

increases expression

Curcumin results in increased expression of PPDPF mRNA

NCBI chr20:63,520,741...63,522,206
Ensembl chr20:63,520,765...63,522,206

G

peptidylprolyl isomerase F

increases expression

Curcumin results in increased expression of PPIF mRNA

NCBI chr10:79,347,469...79,355,334
Ensembl chr10:79,347,469...79,355,334

G

protein phosphatase 1 catalytic subunit alpha

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of PPP1CA protein]

NCBI chr11:67,398,183...67,401,858
Ensembl chr11:67,398,181...67,421,183

G

protein phosphatase 1 regulatory inhibitor subunit 1B

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of PPP1R1B protein]

NCBI chr17:39,626,707...39,636,624
Ensembl chr17:39,626,740...39,636,626

G

protein phosphatase 2 catalytic subunit alpha

multiple interactions

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPP2CA mRNA]

NCBI chr 5:134,194,332...134,226,073
Ensembl chr 5:134,194,035...134,226,073

G

protein phosphatase 3 catalytic subunit gamma

decreases expression

Curcumin results in decreased expression of PPP3CC mRNA

NCBI chr 8:22,441,078...22,541,125
Ensembl chr 8:22,440,819...22,541,142

G

protein phosphatase 5 catalytic subunit

multiple interactions

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPP5C mRNA]

NCBI chr19:46,347,087...46,390,975
Ensembl chr19:46,347,087...46,392,981

G

peroxiredoxin 5

multiple interactions

Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of PRDX5 protein]

NCBI chr11:64,318,121...64,321,811
Ensembl chr11:64,318,121...64,321,811

G

protein kinase AMP-activated catalytic subunit alpha 1

increases phosphorylation

Curcumin results in increased phosphorylation of PRKAA1 protein

NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374

G

protein kinase C alpha

multiple interactions
decreases expression

[PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; PRKCA protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]
Curcumin analog results in decreased expression of PRKCA mRNA

PMID:17178710 PMID:18357586 PMID:26409325

NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743

G

protein kinase C delta

multiple interactions
affects binding
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Curcumin inhibits the reaction [PRKCD protein results in increased expression of IVL mRNA]; Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; PRKCD protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Staurosporine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Wortmannin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]
Curcumin results in increased phosphorylation of and results in increased degradation of PRKCD protein
Curcumin binds to PRKCD protein

PMID:17148446 PMID:17171638 PMID:18357586 PMID:19161989

NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717

G

protein kinase C epsilon

multiple interactions
decreases expression
decreases response to substance

Curcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA]
Curcumin analog results in decreased expression of PRKCE mRNA
PRKCE protein results in decreased susceptibility to Curcumin

PMID:14742295 PMID:17148446 PMID:26409325

NCBI chr 2:45,651,279...46,187,990
Ensembl chr 2:45,651,345...46,187,990

G

protein kinase C eta

multiple interactions

Curcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA]

NCBI chr14:61,187,468...61,550,976
Ensembl chr14:61,187,559...61,550,976

G

protein kinase C theta

multiple interactions

Curcumin inhibits the reaction [Fructose results in increased phosphorylation of PRKCQ protein]

NCBI chr10:6,394,097...6,580,646
Ensembl chr10:6,427,143...6,580,301

G

protein kinase, DNA-activated, catalytic subunit

multiple interactions
decreases expression

Curcumin inhibits the reaction [Arsenic results in decreased expression of PRKDC mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PRKDC protein]
Curcumin results in decreased expression of PRKDC mRNA

PMID:17596214 PMID:21332098

NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

Curcumin inhibits the reaction [Cisplatin results in increased expression of PRKN protein]

NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775

G

prolactin receptor

increases expression

Curcumin results in increased expression of PRLR mRNA

NCBI chr 5:35,048,756...35,230,487
Ensembl chr 5:35,048,756...35,230,487

G

prominin 1

multiple interactions
decreases expression

WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 protein]
Curcumin results in decreased expression of PROM1 mRNA; Curcumin results in decreased expression of PROM1 protein

NCBI chr 4:15,968,228...16,084,023
Ensembl chr 4:15,963,076...16,084,378

G

patched 1

multiple interactions

[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of PTCH1 mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of PTCH1 mRNA]

NCBI chr 9:95,442,980...95,516,971
Ensembl chr 9:95,442,980...95,517,057

G

phosphatase and tensin homolog

multiple interactions

Curcumin inhibits the reaction [bisphenol A results in increased expression of PTEN protein]

NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930

G

prostaglandin E synthase

multiple interactions

Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGES protein]

NCBI chr 9:129,738,349...129,753,042
Ensembl chr 9:129,738,331...129,753,042

G

prostaglandin E synthase 2

multiple interactions

Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGES2 protein]

NCBI chr 9:128,120,693...128,128,440
Ensembl chr 9:128,120,693...128,128,462

G

prostaglandin-endoperoxide synthase 1

decreases expression

Curcumin results in decreased expression of PTGS1 mRNA

NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703

G

prostaglandin-endoperoxide synthase 2

decreases expression
increases expression
multiple interactions
affects expression

Curcumin analog results in decreased expression of PTGS2 mRNA; Curcumin results in decreased expression of PTGS2 mRNA; Curcumin results in decreased expression of PTGS2 protein
Curcumin analog results in increased expression of PTGS2 mRNA
[Curcumin co-treated with Gemcitabine] results in decreased expression of PTGS2 protein; Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Chloranil results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]]
Curcumin results in increased expression of PTGS2 mRNA
[Curcumin co-treated with Azoxymethane] results in increased expression of PTGS2 mRNA; [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Quartz results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of PTGS2 protein]
Curcumin affects the expression of PTGS2 mRNA
[Fluorouracil co-treated with Curcumin] results in decreased expression of PTGS2 protein; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased activity of PTGS2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of PTGS2 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of PTGS2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PTGS2 protein]

PMID:15129424 PMID:15489888 PMID:15841493 PMID:15911101 PMID:16023083 More...

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

parathyroid hormone like hormone

multiple interactions

Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein]

NCBI chr12:27,958,084...27,972,733
Ensembl chr12:27,958,084...27,972,733

G

protein tyrosine phosphatase non-receptor type 13

decreases expression

Curcumin results in decreased expression of PTPN13 mRNA

NCBI chr 4:86,594,315...86,815,161
Ensembl chr 4:86,594,315...86,815,171

G

protein tyrosine phosphatase non-receptor type 6

increases expression

Curcumin results in increased expression of PTPN6 mRNA

NCBI chr12:6,946,577...6,961,316
Ensembl chr12:6,946,468...6,961,316

G

protein tyrosine phosphatase non-receptor type 7

increases expression

Curcumin results in increased expression of PTPN7 mRNA

NCBI chr 1:202,147,013...202,161,588
Ensembl chr 1:202,147,013...202,161,588

G

protein tyrosine phosphatase receptor type O

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTPRO mRNA]

NCBI chr12:15,322,508...15,598,331
Ensembl chr12:15,322,257...15,602,175

G

protein tyrosine phosphatase receptor type R

decreases expression

Curcumin results in decreased expression of PTPRR mRNA

NCBI chr12:70,638,073...70,920,738
Ensembl chr12:70,638,073...70,920,738

G

pentraxin 3

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTX3 mRNA]

NCBI chr 3:157,436,850...157,443,633
Ensembl chr 3:157,436,850...157,443,633

G

PYD and CARD domain containing

multiple interactions

Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of PYCARD mRNA]

NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450

G

RAB8A, member RAS oncogene family

decreases expression

Curcumin results in decreased expression of RAB8A mRNA

NCBI chr19:16,111,889...16,134,234
Ensembl chr19:16,111,889...16,134,234

G

Rac family small GTPase 1

multiple interactions

Curcumin inhibits the reaction [Doxorubicin results in increased expression of RAC1 mRNA]

NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967

G

RAD51 recombinase

multiple interactions

[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA; acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; RAD51 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]; U 0126 promotes the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]

NCBI chr15:40,694,733...40,732,340
Ensembl chr15:40,694,774...40,732,340

G

Raf-1 proto-oncogene, serine/threonine kinase

increases activity
multiple interactions

Curcumin results in increased activity of RAF1 protein
piperlongumine inhibits the reaction [Curcumin results in increased activity of RAF1 protein]

NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201

G

receptor activity modifying protein 1

decreases expression

Curcumin results in decreased expression of RAMP1 mRNA

NCBI chr 2:237,858,880...237,912,106
Ensembl chr 2:237,858,893...237,912,106

G

retinoic acid receptor alpha

multiple interactions

Curcumin inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA]

NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643

G

Ras association domain family member 2

increases expression

Curcumin results in increased expression of RASSF2 mRNA

NCBI chr20:4,780,023...4,823,608
Ensembl chr20:4,780,023...4,823,608

G

RB transcriptional corepressor 1

decreases phosphorylation
multiple interactions

Curcumin results in decreased phosphorylation of RB1 protein
Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of RB1 protein]

PMID:15738001 PMID:18156803 PMID:23222814

NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436

G

RNA binding motif protein 39

increases expression

Curcumin results in increased expression of RBM39 mRNA

NCBI chr20:35,701,347...35,742,260
Ensembl chr20:35,701,347...35,742,312

G

retinol binding protein 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RBP1 mRNA]

NCBI chr 3:139,517,438...139,539,742
Ensembl chr 3:139,517,434...139,539,829

G

regenerating family member 3 alpha

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of REG3A mRNA]

NCBI chr 2:79,157,006...79,159,753
Ensembl chr 2:79,157,003...79,159,753

G

regenerating family member 3 gamma

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of REG3G mRNA]

NCBI chr 2:79,025,702...79,028,501
Ensembl chr 2:79,025,686...79,028,505

G

REL proto-oncogene, NF-kB subunit

multiple interactions
increases expression

Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of REL mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]; Curcumin promotes the reaction [Hydrogen Peroxide results in increased expression of REL protein]
Curcumin results in increased expression of REL protein

PMID:23452621 PMID:31521693

NCBI chr 2:60,881,574...60,931,612
Ensembl chr 2:60,881,491...60,931,612

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases expression
increases activity
affects activity
increases expression
decreases localization
decreases activity

[Curcumin co-treated with Isoflavones] results in decreased activity of RELA protein; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [Acids results in increased activity of RELA protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of RELA protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of RELA protein modified form]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of RELA]; Curcumin inhibits the reaction [Formaldehyde results in increased expression of RELA protein]; Curcumin inhibits the reaction [Glucose results in increased activity of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of and results in increased localization of RELA protein]; Curcumin inhibits the reaction [lauric acid results in increased activity of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]]; Curcumin inhibits the reaction [NFKBIA protein results in increased degradation of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency affects the localization of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RELA mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased activity of RELA protein]; Curcumin inhibits the reaction [quinocetone results in increased expression of RELA mRNA]; Curcumin inhibits the reaction [RELA protein binds to MST1R promoter]; Curcumin inhibits the reaction [RELA protein results in increased expression of MST1R mRNA]; Curcumin inhibits the reaction [Sodium Fluoride results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin results in decreased activity of [NFKB1 protein binds to RELA protein]; Curcumin results in decreased expression of and results in decreased activity of RELA protein; Curcumin results in decreased phosphorylation of and affects the localization of RELA protein; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased activity of RELA protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased expression of RELA mRNA]]
[Curcumin co-treated with Gemcitabine] results in decreased expression of RELA protein; Curcumin analog inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of RELA protein]; Curcumin inhibits the reaction [Chloranil affects the localization of RELA protein modified form]; Curcumin inhibits the reaction [Chloranil results in increased expression of RELA protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [NFKB1 protein binds to RELA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
Curcumin results in decreased expression of RELA protein
Curcumin results in increased activity of RELA protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of and results in decreased phosphorylation of RELA protein; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of RELA protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of RELA protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Curcumin inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]]; Curcumin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [Streptozocin affects the localization of RELA protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of RELA protein]; Curcumin results in increased expression of and results in increased activity of RELA protein; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; NFE2L2 protein promotes the reaction [Curcumin results in increased activity of RELA protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of RELA protein]]
Curcumin affects the activity of RELA protein
Curcumin results in increased expression of RELA
Curcumin results in decreased localization of RELA protein
Curcumin results in decreased expression of RELA; Curcumin results in decreased expression of RELA mRNA; Curcumin results in decreased expression of RELA protein

PMID:12216086 PMID:12388107 PMID:15489888 PMID:15911101 PMID:16023083 More...

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

RELB proto-oncogene, NF-kB subunit

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RELB mRNA]

NCBI chr19:45,001,464...45,038,192
Ensembl chr19:45,001,461...45,038,192

G

reelin

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of RELN mRNA]
Curcumin results in increased expression of RELN mRNA

NCBI chr 7:103,471,789...103,989,658
Ensembl chr 7:103,471,381...103,989,658

G

resistin like beta

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RETNLB mRNA]

NCBI chr 3:108,755,638...108,757,410
Ensembl chr 3:108,743,424...108,757,410

G

REV3 like, DNA directed polymerase zeta catalytic subunit

increases expression

Curcumin results in increased expression of REV3L protein

NCBI chr 6:111,299,033...111,483,711
Ensembl chr 6:111,299,028...111,483,715

G

regulatory factor X associated protein

decreases expression

Curcumin results in decreased expression of RFXAP mRNA

NCBI chr13:36,819,222...36,829,104
Ensembl chr13:36,819,222...36,829,104

G

regulator of G protein signaling 16

increases expression

Curcumin results in increased expression of RGS16 mRNA

NCBI chr 1:182,598,623...182,604,389
Ensembl chr 1:182,598,623...182,604,389

G

regulator of G protein signaling 4

decreases expression

Curcumin results in decreased expression of RGS4 mRNA

NCBI chr 1:163,068,871...163,076,802
Ensembl chr 1:163,068,775...163,076,802

G

regulator of G protein signaling 7

decreases expression

Curcumin results in decreased expression of RGS7 mRNA

NCBI chr 1:240,774,742...241,357,230
Ensembl chr 1:240,767,636...241,357,374

G

ras homolog family member A

decreases expression

Curcumin analog results in decreased expression of RHOA mRNA

NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998

G

ras homolog family member B

decreases expression

Curcumin analog results in decreased expression of RHOB mRNA

NCBI chr 2:20,447,074...20,449,440
Ensembl chr 2:20,447,074...20,449,440

G

regulating synaptic membrane exocytosis 2

decreases expression

Curcumin results in decreased expression of RIMS2 mRNA

NCBI chr 8:103,500,610...104,256,094
Ensembl chr 8:103,500,610...104,254,430

G

receptor interacting serine/threonine kinase 1

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA]

NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,824...3,115,187

G

ribosomal protein L31

increases expression

Curcumin results in increased expression of RPL31 mRNA

NCBI chr 2:101,002,289...101,019,724
Ensembl chr 2:101,002,229...101,024,032

G

ribosomal protein S6

multiple interactions
decreases phosphorylation

calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of RPS6 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased expression of RPS6 protein]; Curcumin results in decreased phosphorylation of and results in decreased expression of RPS6 protein

PMID:18790744 PMID:21450334 PMID:23222814 PMID:34634291

NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236

G

ribosomal protein S6 kinase B1

decreases phosphorylation
multiple interactions

Curcumin results in decreased phosphorylation of RPS6KB1 protein
Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of RPS6KB1 protein]
Curcumin analog inhibits the reaction [Oxygen deficiency results in increased phosphorylation of RPS6KB1 protein]

PMID:18790744 PMID:20554536 PMID:27363783 PMID:34634291

NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574

G

ras responsive element binding protein 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of RREB1 mRNA]

NCBI chr 6:7,107,743...7,251,980
Ensembl chr 6:7,107,597...7,251,980

G

rhotekin

multiple interactions

Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Butyrates]; Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Fluorouracil]; Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Paclitaxel]

NCBI chr 2:74,425,835...74,441,937
Ensembl chr 2:74,425,835...74,442,422

G

RUNX family transcription factor 2

decreases expression

Curcumin results in decreased expression of RUNX2 protein

NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349

G

retinoid X receptor alpha

multiple interactions

Curcumin promotes the reaction [VDR protein binds to RXRA protein]

NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585

G

S100 calcium binding protein A8

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of S100A8 mRNA]

NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073

G

S100 calcium binding protein A9

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of S100A9 mRNA]

NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023

G

S100 calcium binding protein G

affects expression

Curcumin affects the expression of S100G mRNA

NCBI chr X:16,650,158...16,654,670
Ensembl chr X:16,650,158...16,654,670

G

scavenger receptor class B member 1

affects expression

Curcumin affects the expression of SCARB1 mRNA

NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668

G

stearoyl-CoA desaturase

decreases expression

Curcumin results in decreased expression of SCD mRNA

PMID:20816778 PMID:27208389

NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826

G

secernin 2

decreases expression

Curcumin results in decreased expression of SCRN2 mRNA

NCBI chr17:47,837,692...47,841,273
Ensembl chr17:47,837,692...47,841,289

G

succinate dehydrogenase complex flavoprotein subunit A

decreases expression

Curcumin results in decreased expression of SDHA mRNA

NCBI chr 5:218,320...268,746
Ensembl chr 5:218,303...257,082

G

selectin E

multiple interactions
affects expression

Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELE protein]
Curcumin inhibits the reaction [Particulate Matter results in increased expression of SELE protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of SELE protein]
Curcumin affects the expression of SELE protein

PMID:17960570 PMID:18565277 PMID:29244817

NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705

G

selectin L

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA]

NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702

G

selectin P

multiple interactions

Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELP protein]
Curcumin inhibits the reaction [Particulate Matter results in increased expression of SELP protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of SELP protein]

PMID:18565277 PMID:29244817

NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193

G

septin 7

increases expression

Curcumin results in increased expression of SEPTIN7 mRNA

NCBI chr 7:35,800,986...35,915,763
Ensembl chr 7:35,800,932...35,907,110

G

serpin family A member 3

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINA3 mRNA]

NCBI chr14:94,612,391...94,624,053
Ensembl chr14:94,612,384...94,624,055

G

serpin family B member 2

increases expression

Curcumin results in increased expression of SERPINB2 mRNA

NCBI chr18:63,887,705...63,903,888
Ensembl chr18:63,871,692...63,903,888

G

serpin family B member 5

increases expression
multiple interactions

[Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein; Curcumin results in increased expression of SERPINB5 mRNA; Curcumin results in increased expression of SERPINB5 protein
[Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein

PMID:17290611 PMID:19944674

NCBI chr18:63,476,958...63,505,085
Ensembl chr18:63,476,958...63,505,085

G

serpin family E member 1

increases expression
multiple interactions

Curcumin results in increased expression of SERPINE1 mRNA
Curcumin inhibits the reaction [Bleomycin results in increased expression of SERPINE1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of SERPINE1 protein]

PMID:15713895 PMID:35716765

NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247

G

serpin family E member 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINE2 mRNA]

NCBI chr 2:223,975,045...224,039,286
Ensembl chr 2:223,975,045...224,039,318

G

serpin family H member 1

multiple interactions

Curcumin inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA]

NCBI chr11:75,562,253...75,572,783
Ensembl chr11:75,562,056...75,572,783

G

splicing factor proline and glutamine rich

increases expression

Curcumin results in increased expression of SFPQ mRNA

NCBI chr 1:35,176,380...35,193,145
Ensembl chr 1:35,176,378...35,193,446

G

secreted frizzled related protein 2

decreases expression
multiple interactions

Curcumin results in decreased expression of SFRP2 mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of SFRP2 mRNA]

NCBI chr 4:153,780,591...153,789,083
Ensembl chr 4:153,780,591...153,789,083

G

secreted frizzled related protein 5

decreases expression

Curcumin results in decreased expression of SFRP5 mRNA

NCBI chr10:97,766,751...97,771,999
Ensembl chr10:97,766,751...97,771,999

G

sideroflexin 1

decreases expression

Curcumin results in decreased expression of SFXN1 mRNA

NCBI chr 5:175,478,560...175,529,742
Ensembl chr 5:175,477,062...175,529,742

G

sonic hedgehog signaling molecule

multiple interactions

[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SHH mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of SHH mRNA]

NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463

G

SIM bHLH transcription factor 2

multiple interactions

Curcumin inhibits the reaction [Glucose results in increased expression of SIM2 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of SIM2 protein]

NCBI chr21:36,699,115...36,749,917
Ensembl chr21:36,699,115...36,749,917

G

sirtuin 1

increases expression
multiple interactions

Curcumin results in increased expression of SIRT1 mRNA
Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of SIRT1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of SIRT1 protein]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of SIRT1 protein]

PMID:18403477 PMID:32569592 PMID:36037877

NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390

G

sirtuin 3

multiple interactions

Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 protein]; Curcumin inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of SIRT3 protein]
Curcumin inhibits the reaction [[GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA]]

PMID:26422756 PMID:28698153 PMID:28951138

NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931

G

sirtuin 6

multiple interactions

Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT6 mRNA]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT6 protein]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]

NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566

G

sirtuin 7

decreases expression

Curcumin results in decreased expression of SIRT7

NCBI chr17:81,911,939...81,918,176
Ensembl chr17:81,911,939...81,921,323

G

src kinase associated phosphoprotein 2

decreases expression

Curcumin results in decreased expression of SKAP2 mRNA

NCBI chr 7:26,654,770...26,864,590
Ensembl chr 7:26,667,068...26,995,239

G

solute carrier family 11 member 2

increases expression

Curcumin results in increased expression of SLC11A2 mRNA

NCBI chr12:50,952,263...51,028,886
Ensembl chr12:50,979,401...51,028,566

G

solute carrier family 16 member 1

decreases expression

Curcumin results in decreased expression of SLC16A1 protein

NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593

G

solute carrier family 18 member A2

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of SLC18A2 protein]

NCBI chr10:117,241,114...117,279,430
Ensembl chr10:117,241,093...117,279,430

G

solute carrier family 1 member 3

multiple interactions

Curcumin inhibits the reaction [Streptozocin results in decreased expression of SLC1A3 mRNA]

NCBI chr 5:36,606,606...36,688,334
Ensembl chr 5:36,596,588...36,688,334

G

solute carrier family 20 member 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SLC20A1 mRNA]

NCBI chr 2:112,645,939...112,663,825
Ensembl chr 2:112,645,939...112,663,825

G

solute carrier family 2 member 1

decreases expression
multiple interactions

Curcumin results in decreased expression of SLC2A1 mRNA
ATF4 inhibits the reaction [Curcumin results in decreased expression of SLC2A1 protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of SLC2A1 protein]

PMID:21397623 PMID:36640941

NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893

G

solute carrier family 2 member 2

decreases expression
multiple interactions

Curcumin results in decreased expression of SLC2A2 mRNA
Curcumin inhibits the reaction [Streptozocin results in decreased expression of SLC2A2 protein]

PMID:21397623 PMID:25541178

NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743

G

solute carrier family 2 member 3

decreases expression

Curcumin results in decreased expression of SLC2A3 mRNA

NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...8,019,007

G

solute carrier family 2 member 5

decreases expression

Curcumin results in decreased expression of SLC2A5 mRNA

NCBI chr 1:9,035,106...9,094,195
Ensembl chr 1:9,035,106...9,088,478

G

solute carrier family 30 member 1

increases expression

Curcumin results in increased expression of SLC30A1 mRNA

NCBI chr 1:211,571,568...211,579,161
Ensembl chr 1:211,571,568...211,579,161

G

solute carrier family 30 member 10

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SLC30A10 mRNA]

NCBI chr 1:219,910,445...219,959,098
Ensembl chr 1:219,685,427...219,959,018

G

solute carrier family 37 member 4

decreases expression

Curcumin results in decreased expression of SLC37A4 mRNA

NCBI chr11:119,024,112...119,030,877
Ensembl chr11:119,023,751...119,030,906

G

solute carrier family 3 member 2

increases expression

Curcumin results in increased expression of SLC3A2 mRNA

PMID:17198877 PMID:19183254

NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,004...62,888,880

G

solute carrier family 48 member 1

increases expression

Curcumin results in increased expression of SLC48A1 mRNA

NCBI chr12:47,753,934...47,782,751
Ensembl chr12:47,753,916...47,782,751

G

solute carrier family 6 member 3

multiple interactions

Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC6A3 protein]

NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440

G

solute carrier family 7 member 11

increases expression

Curcumin results in increased expression of SLC7A11 mRNA

PMID:17999991 PMID:19183254

NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349

G

solute carrier organic anion transporter family member 1A2

increases expression

Curcumin results in increased expression of SLCO1A2 mRNA

NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594

G

secretory leukocyte peptidase inhibitor

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SLPI mRNA]

NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564

G

SMAD family member 2

multiple interactions

Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD2 protein]

NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146

G

SMAD family member 3

multiple interactions

Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD3 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein]]

PMID:16959952 PMID:26648693 PMID:32718261

NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173

G

SMAD family member 4

multiple interactions
decreases expression

Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]
Curcumin results in decreased expression of SMAD4 mRNA

PMID:16959952 PMID:27237783

NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045

G

survival of motor neuron 2, centromeric

increases expression
multiple interactions

Curcumin results in increased expression of SMN2 protein
Curcumin affects the splicing of and results in increased expression of SMN2 mRNA alternative form

NCBI chr 5:70,049,523...70,090,528
Ensembl chr 5:70,049,638...70,078,522
Ensembl chr 5:70,049,638...70,078,522

G

smoothened, frizzled class receptor

multiple interactions

[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SMO mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of SMO mRNA]

NCBI chr 7:129,188,633...129,213,545
Ensembl chr 7:129,188,633...129,213,545

G

small muscle protein X-linked

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SMPX mRNA]

NCBI chr X:21,705,978...21,758,116
Ensembl chr X:21,705,978...21,758,116

G

snail family transcriptional repressor 1

multiple interactions

Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of SNAI1 protein]

PMID:25656647 PMID:34233590

NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886

G

snail family transcriptional repressor 2

decreases expression

Curcumin results in decreased expression of SNAI2 protein

NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740

G

synuclein alpha

multiple interactions

[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of SNCA protein]

PMID:31187328 PMID:31820278

NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315

G

small nucleolar RNA host gene 12

decreases expression

Curcumin results in decreased expression of SNHG12 mRNA

NCBI chr 1:28,578,538...28,582,983
Ensembl chr 1:28,578,538...28,583,132

G

suppressor of cytokine signaling 3

decreases expression

Curcumin results in decreased expression of SOCS3 mRNA

PMID:18403477 PMID:25822711

NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077

G

suppressor of cytokine signaling 5

decreases expression

Curcumin results in decreased expression of SOCS5 protein

NCBI chr 2:46,698,937...46,763,129
Ensembl chr 2:46,698,952...46,780,245

G

superoxide dismutase 1

multiple interactions
increases expression

[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; [Curcumin co-treated with Vitamin E] promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased activity of SOD1 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; Curcumin promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of SOD1 protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of SOD1 protein]
Curcumin results in increased expression of SOD1 protein
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of SOD1 mRNA]

PMID:19914224 PMID:25996037 PMID:30934151 PMID:31521693 PMID:35063475 More...

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

superoxide dismutase 2

affects expression
increases expression
multiple interactions

Curcumin affects the expression of SOD2 mRNA; Curcumin affects the expression of SOD2 protein
Curcumin results in increased expression of SOD2 protein
Curcumin results in increased expression of SOD2 mRNA; Curcumin results in increased expression of SOD2 protein
2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of SOD2 mRNA]
Curcumin analog inhibits the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in decreased expression of and results in decreased activity of SOD2 protein]; Curcumin analog inhibits the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in increased expression of and results in decreased activity of SOD2 protein]; Curcumin analog promotes the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in increased expression of SOD2 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD2 mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of SOD2 protein]; Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]]
[Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased expression of SOD2 mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of SOD2 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased activity of SOD2 protein]; Curcumin promotes the reaction [Thyroxine results in increased expression of SOD2 protein]

PMID:11543823 PMID:18299980 PMID:19914224 PMID:22316666 PMID:23452621 More...

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

SRY-box transcription factor 2

increases expression

Curcumin results in increased expression of SOX2 mRNA; Curcumin results in increased expression of SOX2 protein

NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436

G

SRY-box transcription factor 9

multiple interactions
increases expression

[Curcumin co-treated with resveratrol] results in increased expression of SOX9 protein
Curcumin results in increased expression of SOX9 protein

NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416

G

Sp1 transcription factor

decreases expression

Curcumin results in decreased expression of SP1 protein

PMID:18347134 PMID:18593936

NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446

G

Sp3 transcription factor

decreases expression

Curcumin results in decreased expression of SP3 protein

NCBI chr 2:173,900,775...173,965,702
Ensembl chr 2:173,880,850...173,965,373

G

Sp4 transcription factor

decreases expression

Curcumin results in decreased expression of SP4 protein

NCBI chr 7:21,428,083...21,514,822
Ensembl chr 7:21,428,043...21,514,822

G

secreted protein acidic and cysteine rich

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA]

NCBI chr 5:151,661,096...151,686,915
Ensembl chr 5:151,661,096...151,686,975

G

Spi-B transcription factor

increases expression

Curcumin results in increased expression of SPIB mRNA

NCBI chr19:50,418,938...50,431,314
Ensembl chr19:50,418,938...50,431,314

G

SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1

increases expression

Curcumin results in increased expression of SPOCK1 mRNA

NCBI chr 5:136,975,298...137,499,326
Ensembl chr 5:136,975,298...137,598,379

G

secreted phosphoprotein 1

multiple interactions

Curcumin inhibits the reaction [Cadmium Chloride results in increased export of SPP1 protein]

NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532

G

squalene epoxidase

decreases expression
affects expression

Curcumin results in decreased expression of SQLE mRNA
Curcumin affects the expression of SQLE mRNA

NCBI chr 8:124,998,505...125,022,283
Ensembl chr 8:124,998,497...125,022,283

G

sequestosome 1

decreases expression
multiple interactions
increases expression

Curcumin results in decreased expression of SQSTM1 protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of SQSTM1 protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of SQSTM1 protein]; Curcumin inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; Curcumin inhibits the reaction [Tunicamycin results in decreased expression of SQSTM1 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]]
Curcumin results in increased expression of SQSTM1 protein

PMID:34634291 PMID:34758851 PMID:36640941

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

SRC proto-oncogene, non-receptor tyrosine kinase

decreases expression
multiple interactions
decreases activity

Curcumin results in decreased expression of SRC protein
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in decreased activity of SRC protein
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of SRC protein]
Curcumin analog results in decreased activity of SRC protein; Curcumin results in decreased activity of SRC protein

PMID:16959222 PMID:33617879

NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050

G

sterol regulatory element binding transcription factor 1

affects expression
multiple interactions
decreases expression

Curcumin affects the expression of SREBF1 mRNA; Curcumin affects the expression of SREBF1 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF1 protein]
Curcumin results in decreased expression of SREBF1 mRNA

PMID:27208389 PMID:37701206

NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002

G

sterol regulatory element binding transcription factor 2

affects expression
multiple interactions
decreases expression

Curcumin affects the expression of SREBF2 mRNA; Curcumin affects the expression of SREBF2 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF2 protein]
Curcumin results in decreased expression of SREBF2 mRNA

PMID:27208389 PMID:37701206

NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,105...41,907,306

G

spermidine synthase

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SRM mRNA]

NCBI chr 1:11,054,589...11,060,018
Ensembl chr 1:11,054,584...11,060,020

G

serine and arginine rich splicing factor 1

increases expression

Curcumin results in increased expression of SRSF1 mRNA

NCBI chr17:57,989,038...58,007,246
Ensembl chr17:58,000,919...58,007,346

G

serine and arginine rich splicing factor 2

increases expression

Curcumin results in increased expression of SRSF2 mRNA

NCBI chr17:76,734,115...76,737,411
Ensembl chr17:76,734,115...76,737,333

G

serine and arginine rich splicing factor 3

increases expression

Curcumin results in increased expression of SRSF3 mRNA

NCBI chr 6:36,594,362...36,605,600
Ensembl chr 6:36,594,353...36,605,600

G

serine and arginine rich splicing factor 5

decreases expression

Curcumin results in decreased expression of SRSF5 mRNA

NCBI chr14:69,767,142...69,772,005
Ensembl chr14:69,726,900...69,772,005

G

serine and arginine rich splicing factor 6

increases expression

Curcumin results in increased expression of SRSF6 mRNA

NCBI chr20:43,457,896...43,464,243
Ensembl chr20:43,457,893...43,466,046

G

signal transducer and activator of transcription 1

multiple interactions

Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT1 protein]
Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]

PMID:16959222 PMID:21811692

NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960

G

signal transducer and activator of transcription 3

multiple interactions
decreases expression
increases phosphorylation
decreases phosphorylation

Arsenic Trioxide promotes the reaction [Curcumin results in decreased expression of STAT3 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased phosphorylation of STAT3 protein]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of STAT3 protein]
Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of STAT3 mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]
Curcumin results in decreased expression of STAT3 mRNA
Curcumin results in increased phosphorylation of STAT3 protein
Curcumin results in decreased expression of STAT3 mRNA; Curcumin results in decreased expression of STAT3 protein

PMID:16959222 PMID:17666914 PMID:19383353 PMID:20816778 PMID:25822711 More...

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

signal transducer and activator of transcription 4

multiple interactions

Curcumin promotes the reaction [IFNB1 protein results in increased phosphorylation of STAT4 protein]

NCBI chr 2:191,029,576...191,151,596
Ensembl chr 2:191,029,576...191,151,596

G

signal transducer and activator of transcription 5A

increases cleavage
decreases expression

Curcumin results in increased cleavage of STAT5A protein
Curcumin results in decreased expression of STAT5A protein

NCBI chr17:42,287,439...42,311,943
Ensembl chr17:42,287,547...42,311,943

G

signal transducer and activator of transcription 5B

increases cleavage
decreases expression

Curcumin results in increased cleavage of STAT5B protein
Curcumin results in decreased expression of STAT5B protein

NCBI chr17:42,199,177...42,288,370
Ensembl chr17:42,199,176...42,288,633

G

steroid sulfatase

decreases expression

Curcumin results in decreased expression of STS mRNA

NCBI chr X:7,147,290...7,354,641
Ensembl chr X:7,147,237...7,804,358

G

syntaxin 3

multiple interactions

[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of STX3 mRNA

NCBI chr11:59,754,188...59,805,878
Ensembl chr11:59,713,456...59,805,882

G

sulfatase 1

increases expression

Curcumin results in increased expression of SULF1 mRNA; Curcumin results in increased expression of SULF1 protein

NCBI chr 8:69,466,781...69,660,912
Ensembl chr 8:69,466,624...69,660,915

G

sulfatase 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SULF2 mRNA]

NCBI chr20:47,657,406...47,786,627
Ensembl chr20:47,656,197...47,786,616

G

SUZ12 polycomb repressive complex 2 subunit

decreases expression

Curcumin results in decreased expression of SUZ12 mRNA

NCBI chr17:31,937,007...32,001,038
Ensembl chr17:31,937,007...32,001,038

G

synaptonemal complex protein 2

increases expression

Curcumin results in increased expression of SYCP2 mRNA

NCBI chr20:59,863,571...59,933,637
Ensembl chr20:59,863,564...59,933,655

G

synapsin II

multiple interactions

Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SYN2 protein]

NCBI chr 3:12,004,388...12,192,032
Ensembl chr 3:12,004,388...12,192,032

G

synaptic Ras GTPase activating protein 1

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in increased expression of SYNGAP1 protein]

NCBI chr 6:33,418,167...33,453,689
Ensembl chr 6:33,419,661...33,453,689

G

transcriptional adaptor 3

affects expression

Curcumin affects the expression of TADA3 mRNA

NCBI chr 3:9,779,967...9,793,011
Ensembl chr 3:9,779,967...9,793,011

G

transaldolase 1

increases expression

Curcumin results in increased expression of TALDO1 mRNA

NCBI chr11:747,464...765,012
Ensembl chr11:747,415...765,012

G

TBC1 domain family member 1

decreases expression

Curcumin results in decreased expression of TBC1D1 mRNA

NCBI chr 4:37,891,084...38,139,173
Ensembl chr 4:37,891,084...38,139,175

G

TBC1 domain family member 8

increases expression

Curcumin results in increased expression of TBC1D8 mRNA

NCBI chr 2:101,007,228...101,151,382
Ensembl chr 2:101,007,228...101,252,866

G

TANK binding kinase 1

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA]

NCBI chr12:64,452,120...64,502,114
Ensembl chr12:64,452,090...64,502,114

G

T-box transcription factor T

decreases expression

Curcumin results in decreased expression of T mRNA

NCBI chr 6:166,157,656...166,168,655
Ensembl chr 6:166,157,656...166,168,700

G

transcription factor 7 like 2

multiple interactions

Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]

NCBI chr10:112,950,247...113,167,678
Ensembl chr10:112,950,247...113,167,678

G

telomerase reverse transcriptase

decreases activity

Curcumin results in decreased activity of TERT protein

NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068

G

tet methylcytosine dioxygenase 2

increases expression

curcumin increases expression of TET2 mRNA and protein in stomach

RGD

NCBI chr 4:105,145,875...105,279,803
Ensembl chr 4:105,145,875...105,279,816

G

transferrin

increases expression

Curcumin results in increased expression of TF mRNA

NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641

G

transcription factor A, mitochondrial

multiple interactions

[Curcumin co-treated with Potassium Dichromate] results in increased expression of TFAM protein

NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220

G

transcription factor EB

multiple interactions

[Curcumin co-treated with sodium arsenite] promotes the reaction TFEB protein; NFE2L2 protein affects the reaction [[Curcumin co-treated with sodium arsenite] promotes the reaction TFEB protein]

NCBI chr 6:41,683,978...41,736,223
Ensembl chr 6:41,683,978...41,736,259

G

transferrin receptor

increases expression
multiple interactions

Curcumin results in increased expression of TFRC mRNA
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TFRC protein]

PMID:17198877 PMID:18340409 PMID:24634837

NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153

G

transforming growth factor beta 1

multiple interactions
decreases expression
decreases activity

Curcumin inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA]
[1,2-Dimethylhydrazine co-treated with Curcumin] results in increased expression of TGFB1 mRNA; Curcumin affects the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]
Curcumin results in decreased expression of TGFB1 mRNA; Curcumin results in decreased expression of TGFB1 protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]]; [Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of TGFB1 mRNA]; [Zinc binds to Curcumin] which affects the expression of TGFB1 mRNA; Curcumin analog inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]]
Curcumin results in decreased activity of TGFB1 protein

PMID:8940178 PMID:16751071 PMID:16959952 PMID:17434272 PMID:18006644 More...

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

transforming growth factor beta receptor 1

multiple interactions
decreases expression

2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein]
Curcumin results in decreased expression of TGFBR1 mRNA; Curcumin results in decreased expression of TGFBR1 protein

PMID:16959952 PMID:17531121 PMID:17602960

NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192

G

transforming growth factor beta receptor 2

multiple interactions
decreases expression

Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 protein]
Curcumin results in decreased expression of TGFBR2 mRNA; Curcumin results in decreased expression of TGFBR2 protein

PMID:16959952 PMID:17602960

NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,601...30,694,142

G

transglutaminase 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TGM2 mRNA]

NCBI chr20:38,127,385...38,168,475
Ensembl chr20:38,127,385...38,166,578

G

tyrosine hydroxylase

multiple interactions

[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of TH protein]
Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]

PMID:19631675 PMID:22704994 PMID:27966075 PMID:30463061 PMID:31187328

NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815

G

thrombospondin 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THBS1 mRNA]

NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466

G

Thy-1 cell surface antigen

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THY1 mRNA]

NCBI chr11:119,415,476...119,424,985
Ensembl chr11:119,415,476...119,424,985

G

TIR domain containing adaptor molecule 1

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TICAM1 mRNA]

NCBI chr19:4,815,932...4,831,712
Ensembl chr19:4,815,932...4,831,712

G

TIR domain containing adaptor molecule 2

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TICAM2 mRNA]

NCBI chr 5:115,578,496...115,602,479
Ensembl chr 5:115,578,496...115,602,479

G

TIMP metallopeptidase inhibitor 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 mRNA]
Curcumin inhibits the reaction [Cadmium Chloride results in increased export of TIMP1 protein]
Curcumin results in decreased expression of TIMP1 protein

PMID:17996675 PMID:18200517 PMID:27363783 PMID:29421648

NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789

G

TIMP metallopeptidase inhibitor 2

multiple interactions
decreases expression

Curcumin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]
Curcumin results in decreased expression of TIMP2 protein

PMID:16934674 PMID:17996675

NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387

G

tight junction protein 1

multiple interactions

Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of and affects the localization of TJP1 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of TJP1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TJP1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TJP1 protein]

PMID:26191140 PMID:35817260

NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,915

G

toll like receptor 1

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA]

NCBI chr 4:38,787,569...38,805,644
Ensembl chr 4:38,790,677...38,856,817

G

toll like receptor 2

multiple interactions

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]

PMID:22683883 PMID:23452621

NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,070...153,706,260

G

toll like receptor 4

multiple interactions
decreases expression

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]
Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein]
Curcumin results in decreased expression of TLR4 mRNA; Curcumin results in decreased expression of TLR4 protein

PMID:16678799 PMID:17965732 PMID:19002562 PMID:22683883 PMID:34719837 More...

NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735

G

transmembrane serine protease 2

decreases expression
multiple interactions

Curcumin results in decreased expression of TMPRSS2 mRNA
Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]

PMID:18719366 PMID:22258452

NCBI chr21:41,464,305...41,508,158
Ensembl chr21:41,464,300...41,531,116

G

thiol methyltransferase 1A

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of METTL7A mRNA]

NCBI chr12:50,925,015...50,932,508
Ensembl chr12:50,923,472...50,932,510

G

tenascin C

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNC mRNA]

NCBI chr 9:115,019,575...115,118,157
Ensembl chr 9:115,019,575...115,118,207

G

tumor necrosis factor

multiple interactions
decreases expression
affects expression
increases expression

[Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Curcumin inhibits the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNF protein]; Curcumin inhibits the reaction [TNF protein affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; Curcumin inhibits the reaction [TNF protein results in decreased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of TNF mRNA]; Curcumin inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MYC mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; Curcumin inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]
Curcumin results in decreased expression of TNF mRNA; Curcumin results in decreased expression of TNF protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of TNF protein]; [Zinc binds to Curcumin] inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of TNF protein]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TNF protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in increased expression of TNF protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Curcumin inhibits the reaction [Colistin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Fructose results in increased expression of TNF protein]; Curcumin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of TNF protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELP protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]]
Curcumin affects the expression of TNF mRNA; Curcumin affects the expression of TNF protein
Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of TNF protein]; Curcumin inhibits the reaction [sodium arsenite affects the expression of TNF mRNA]; Curcumin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of TNF mRNA]
Curcumin results in increased expression of TNF mRNA

PMID:14555224 PMID:15489888 PMID:16023083 PMID:16219905 PMID:16584726 More...

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF receptor superfamily member 10a

multiple interactions
increases expression

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10A protein]

PMID:18226269 PMID:23452621

NCBI chr 8:23,190,452...23,225,102
Ensembl chr 8:23,190,452...23,225,102

G

TNF receptor superfamily member 10b

decreases expression
increases expression
multiple interactions
increases response to substance

Curcumin results in decreased expression of TNFRSF10B mRNA
Curcumin results in increased expression of TNFRSF10B protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of TNFRSF10B protein; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10B mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10B protein]
TNFRSF10B protein results in increased susceptibility to Curcumin

PMID:16101141 PMID:16613838 PMID:18226269 PMID:23452621 PMID:27430728

NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031

G

TNF receptor superfamily member 10c

multiple interactions

[arsenic trioxide co-treated with Curcumin] results in increased expression of TNFRSF10C protein

NCBI chr 8:23,102,921...23,117,445
Ensembl chr 8:23,102,921...23,117,445

G

TNF receptor superfamily member 10d

multiple interactions

[arsenic trioxide co-treated with Curcumin] results in increased expression of TNFRSF10D protein

NCBI chr 8:23,135,588...23,164,027
Ensembl chr 8:23,135,588...23,164,027

G

TNF receptor superfamily member 12A

multiple interactions

Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNFRSF12A mRNA]

NCBI chr16:3,020,368...3,022,383
Ensembl chr16:3,018,445...3,022,383

G

TNF receptor superfamily member 1A

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]

PMID:17666914 PMID:23452621

NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114

G

TNF receptor superfamily member 1B

multiple interactions

Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B protein]

NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228

G

TNF receptor superfamily member 21

multiple interactions

[arsenic trioxide co-treated with Curcumin] results in increased expression of TNFRSF21 protein

NCBI chr 6:47,231,532...47,309,905
Ensembl chr 6:47,231,532...47,309,905

G

TNF superfamily member 10

multiple interactions
decreases expression

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFSF10 mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in decreased activity of RELA protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CXCL8 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP9 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PLAU protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PTGS2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of VEGFA protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10A protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10B protein]
Curcumin results in decreased expression of TNFSF10 mRNA

PMID:15713895 PMID:16101141 PMID:18226269 PMID:23452621

NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475

G

TNF superfamily member 11

multiple interactions

Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased expression of PTGS2 protein]
Curcumin inhibits the reaction [IL1A protein results in increased expression of TNFSF11 protein]

PMID:15129424 PMID:18719352

NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013

G

TNF superfamily member 12

multiple interactions

Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNFSF12 protein]

NCBI chr17:7,549,058...7,557,881
Ensembl chr17:7,548,508...7,557,890

G

TNF superfamily member 14

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFSF14 mRNA]

NCBI chr19:6,661,253...6,670,588
Ensembl chr19:6,661,253...6,670,588

G

tankyrase

decreases expression

Curcumin analog results in decreased expression of TNKS mRNA

NCBI chr 8:9,555,912...9,782,346
Ensembl chr 8:9,555,912...9,782,346

G

troponin I3, cardiac type

multiple interactions

Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein]

NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773

G

DNA topoisomerase II alpha

multiple interactions
decreases expression

[Curcumin co-treated with Azacitidine] results in decreased expression of TOP2A mRNA; [sulfinosine co-treated with Curcumin] results in decreased expression of TOP2A mRNA
Curcumin analog results in decreased expression of TOP2A mRNA; Curcumin results in decreased expression of TOP2A mRNA

PMID:18348204 PMID:18414057 PMID:26409325

NCBI chr17:40,388,525...40,417,896
Ensembl chr17:40,388,525...40,417,896

G

DNA topoisomerase II beta

multiple interactions
decreases expression

Curcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B protein]
Curcumin analog results in decreased expression of TOP2B mRNA

PMID:21332098 PMID:26409325

NCBI chr 3:25,597,905...25,664,907
Ensembl chr 3:25,597,978...25,664,909

G

tumor protein p53

multiple interactions
decreases expression
increases expression
increases phosphorylation
increases acetylation
affects expression
affects localization

[Arsenic Trioxide co-treated with Curcumin] results in increased expression of TP53 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of TP53 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of TP53 protein; [piperine co-treated with Curcumin] results in decreased expression of TP53 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of TP53 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; dorsomorphin inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein]; SB 203580 inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein]
Curcumin analog results in decreased expression of TP53 mRNA; Curcumin results in decreased expression of TP53 mRNA; Curcumin results in decreased expression of TP53 protein
Curcumin results in increased expression of TRP53 mRNA
[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TRP53 protein]; Curcumin affects the reaction [KRAS protein affects the localization of TRP53 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of TRP53 protein]
[Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein; Curcumin results in increased expression of TP53; Curcumin results in increased expression of TP53 protein
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TP53 mRNA]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased mutagenesis of TP53 exon]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein]; Curcumin results in decreased expression of and results in decreased acetylation of TP53 protein
Curcumin results in increased acetylation of TP53 protein
Curcumin affects the expression of TP53 protein; Curcumin analog affects the expression of TP53 mRNA; Curcumin analog affects the expression of TP53 protein
Curcumin affects the localization of TP53 protein

PMID:17041101 PMID:17332930 PMID:19020741 PMID:19227835 PMID:19944674 More...

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

tryptophan hydroxylase 1

multiple interactions

[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TPH1 protein]

NCBI chr11:18,017,555...18,046,269
Ensembl chr11:18,017,555...18,046,269

G

TNFRSF1A associated via death domain

decreases expression

Curcumin results in decreased expression of TRADD mRNA

NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909

G

TNF receptor associated factor 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]
Curcumin results in decreased expression of TRAF1 protein

PMID:16023083 PMID:16219905 PMID:19372569

NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173

G

TNF receptor associated factor 2

increases expression

Curcumin results in increased expression of TRAF2 mRNA

NCBI chr 9:136,881,958...136,926,607
Ensembl chr 9:136,881,912...136,926,607

G

TNF receptor associated factor 3

increases expression

Curcumin results in increased expression of TRAF3 mRNA

NCBI chr14:102,777,449...102,911,500
Ensembl chr14:102,777,449...102,911,500

G

TNF receptor associated factor 6

increases expression
multiple interactions

Curcumin results in increased expression of TRAF6 mRNA
Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TRAF6 mRNA]

PMID:16101141 PMID:34719837

NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272

G

tRNA aspartic acid methyltransferase 1

increases expression

Curcumin results in increased expression of DNMT2

NCBI chr10:17,137,336...17,201,672
Ensembl chr10:17,137,336...17,202,054

G

triggering receptor expressed on myeloid cells 1

decreases expression

Curcumin results in decreased expression of TREM1 mRNA

NCBI chr 6:41,267,385...41,286,682
Ensembl chr 6:41,267,926...41,286,682

G

tribbles pseudokinase 3

increases expression

Curcumin results in increased expression of TRIB3 mRNA

NCBI chr20:380,760...397,559
Ensembl chr20:362,835...397,559

G

tripartite motif containing 15

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TRIM15 mRNA]

NCBI chr 6:30,163,546...30,172,693
Ensembl chr 6:30,163,206...30,172,693

G

tripartite motif containing 16

increases expression

Curcumin results in increased expression of TRIM16 mRNA

NCBI chr17:15,627,966...15,684,311
Ensembl chr17:15,627,960...15,684,311

G

transient receptor potential cation channel subfamily V member 6

multiple interactions

[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA

NCBI chr 7:142,871,208...142,885,745
Ensembl chr 7:142,871,208...142,885,745

G

TSC complex subunit 2

decreases phosphorylation

Curcumin results in decreased phosphorylation of TSC2 protein

NCBI chr16:2,047,985...2,089,491
Ensembl chr16:2,047,967...2,089,491

G

tubulin beta 3 class III

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of TUBB3 mRNA]
Curcumin results in increased expression of TUBB3 mRNA

NCBI chr16:89,921,925...89,936,097
Ensembl chr16:89,921,392...89,938,761

G

thioredoxin interacting protein

multiple interactions

Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of TXNIP mRNA]

NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579

G

thioredoxin reductase 1

increases expression
increases oxidation

Curcumin analog results in increased expression of TXNRD1 mRNA; Curcumin results in increased expression of TXNRD1 mRNA
Curcumin results in increased oxidation of TXNRD1 protein

PMID:17198877 PMID:18299980 PMID:21782934 PMID:26409325

NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307

G

thymidine phosphorylase

decreases expression
multiple interactions

Curcumin results in decreased expression of TYMP mRNA; Curcumin results in decreased expression of TYMP protein
[Curcumin results in decreased expression of TYMP protein] which results in increased susceptibility to Cisplatin

NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032

G

transmembrane immune signaling adaptor TYROBP

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TYROBP mRNA]

NCBI chr19:35,904,403...35,908,295
Ensembl chr19:35,904,401...35,908,295

G

ubiquitin like modifier activating enzyme 7

affects expression
multiple interactions

Curcumin affects the expression of UBA7 mRNA; Curcumin affects the expression of UBA7 protein
Curcumin affects the reaction [Acetylcysteine results in increased expression of UBA7 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of UBA7 protein]

NCBI chr 3:49,805,209...49,813,953
Ensembl chr 3:49,805,209...49,813,953

G

ubiquitin C

increases expression

Curcumin results in increased expression of UBC mRNA

NCBI chr12:124,911,646...124,914,650
Ensembl chr12:124,911,604...124,917,368

G

ubiquitin conjugating enzyme E2 C

decreases expression

Curcumin results in decreased expression of UBE2C mRNA

NCBI chr20:45,812,644...45,816,952
Ensembl chr20:45,812,576...45,816,957

G

uncoupling protein 1

affects expression

Curcumin affects the expression of UCP1 mRNA

NCBI chr 4:140,559,431...140,568,961
Ensembl chr 4:140,559,431...140,568,961

G

UDP glucuronosyltransferase family 1 member A complex locus

decreases activity
increases degradation

Curcumin results in decreased activity of UGT1A protein
Curcumin results in increased degradation of UGT1A protein

NCBI chr 2:233,585,439...233,773,299

G

UDP glucuronosyltransferase family 1 member A1

increases expression
multiple interactions
increases glucuronidation

Curcumin results in increased expression of UGT1A1 mRNA
Curcumin analog results in increased expression of UGT1A1 mRNA; Curcumin analog results in increased expression of UGT1A1 protein
Curcumin promotes the reaction [Aflatoxin B1 results in increased activity of UGT1A1 protein]
UGT1A1 protein results in increased glucuronidation of Curcumin

PMID:14557274 PMID:16819192 PMID:20015472 PMID:26991801 PMID:29228771

NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300

G

UDP glucuronosyltransferase family 1 member A10

increases glucuronidation

UGT1A10 protein results in increased glucuronidation of Curcumin

NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300

G

UDP glucuronosyltransferase family 1 member A6

increases expression

Curcumin results in increased expression of UGT1A6 mRNA

NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300

G

UDP glucuronosyltransferase family 1 member A7

increases glucuronidation

UGT1A7 protein results in increased glucuronidation of Curcumin

NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300

G

UDP glucuronosyltransferase family 1 member A8

increases glucuronidation

UGT1A8 protein results in increased glucuronidation of Curcumin

NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of Curcumin

NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300

G

UTP14A small subunit processome component

increases expression

Curcumin results in increased expression of UTP14A mRNA

NCBI chr X:129,906,164...129,929,752
Ensembl chr X:129,906,121...129,929,761

G

vasodilator stimulated phosphoprotein

increases expression

Curcumin results in increased expression of VASP mRNA

NCBI chr19:45,507,479...45,526,983
Ensembl chr19:45,506,579...45,526,989

G

vascular cell adhesion molecule 1

affects expression
multiple interactions

Curcumin affects the expression of VCAM1 mRNA
Curcumin inhibits the reaction [Particulate Matter results in increased expression of VCAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of VCAM1 protein]
Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]; Curcumin inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]
Curcumin analog inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]

PMID:18752423 PMID:28700904 PMID:29244817 PMID:30431687

NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045

G

versican

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VCAN mRNA]

NCBI chr 5:83,471,744...83,582,302
Ensembl chr 5:83,471,618...83,582,303

G

voltage dependent anion channel 1

multiple interactions

Curcumin promotes the reaction [VDAC1 protein binds to VDAC1 protein]

NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975

G

vitamin D receptor

multiple interactions

[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA; Curcumin binds to and results in increased activity of VDR protein; Curcumin inhibits the reaction [1,25-dihydroxy-26,27-dimethylcholecalciferol binds to VDR protein]; Curcumin promotes the reaction [VDR protein binds to NCOA1 protein]; Curcumin promotes the reaction [VDR protein binds to RXRA protein]

NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048

G

vascular endothelial growth factor A

affects expression
decreases expression
multiple interactions

Curcumin affects the expression of VEGFA mRNA
Curcumin results in decreased expression of VEGFA mRNA; Curcumin results in decreased expression of VEGFA protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]
[Curcumin co-treated with Gemcitabine] results in decreased expression of VEGFA protein; Curcumin inhibits the reaction [Dietary Fats results in increased expression of VEGFA mRNA]
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; [Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin analog co-treated with terpestacin] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin analog co-treated with Vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin co-treated with Bortezomib] results in decreased expression of VEGFA protein; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of VEGFA protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; Curcumin results in decreased expression of and results in decreased secretion of VEGFA protein; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of VEGFA protein]

PMID:16219905 PMID:16243823 PMID:16368150 PMID:17440100 PMID:17662242 More...

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

G

von Hippel-Lindau tumor suppressor

multiple interactions

VHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein]

NCBI chr 3:10,141,778...10,153,667
Ensembl chr 3:10,141,778...10,153,667

G

vimentin

multiple interactions

Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]

PMID:25656647 PMID:26191140

NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593

G

vasoactive intestinal peptide

multiple interactions

Curcumin inhibits the reaction [VIP protein results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]
Curcumin inhibits the reaction [VIP protein results in increased expression of PTGS2 protein]

PMID:17434257 PMID:19189304

NCBI chr 6:152,750,797...152,759,760
Ensembl chr 6:152,750,797...152,759,765

G

von Willebrand factor

multiple interactions

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein]

NCBI chr12:5,948,877...6,124,670
Ensembl chr12:5,948,877...6,124,770

G

WASP like actin nucleation promoting factor

increases expression

Curcumin results in increased expression of WASL mRNA

NCBI chr 7:123,681,943...123,749,003
Ensembl chr 7:123,681,943...123,749,003

G

WNT inhibitory factor 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [bisphenol A results in increased expression of WIF1 protein]
Curcumin results in decreased expression of WIF1 protein

NCBI chr12:65,050,626...65,121,305
Ensembl chr12:65,050,626...65,121,305

G

Wnt family member 1

increases expression
multiple interactions

Curcumin results in increased expression of WNT1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT1 mRNA]

NCBI chr12:48,978,322...48,982,620
Ensembl chr12:48,978,322...48,982,620

G

Wnt family member 3

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT3 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT3 protein]
Curcumin results in increased expression of WNT3 mRNA; Curcumin results in increased expression of WNT3 protein

NCBI chr17:46,762,506...46,818,692
Ensembl chr17:46,762,506...46,833,154

G

WT1 transcription factor

decreases expression

Curcumin results in decreased expression of WT1 mRNA; Curcumin results in decreased expression of WT1 protein

PMID:18034345 PMID:19196508

NCBI chr11:32,387,775...32,435,539
Ensembl chr11:32,387,775...32,435,564

G

WW domain containing transcription regulator 1

decreases stability
multiple interactions

Curcumin results in decreased stability of WWTR1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of WWTR1 protein]; Curcumin results in decreased expression of and affects the localization of WWTR1 protein; Curcumin results in increased phosphorylation of and results in decreased stability of WWTR1 protein; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM protein]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 protein]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 protein]; WWTR1 protein inhibits the reaction [Curcumin results in increased susceptibility to Cisplatin]

NCBI chr 3:149,517,235...149,724,788
Ensembl chr 3:149,517,235...149,736,714

G

XIAP associated factor 1

increases expression

Curcumin results in increased expression of XAF1 mRNA; Curcumin results in increased expression of XAF1 protein

NCBI chr17:6,755,447...6,775,647
Ensembl chr17:6,755,447...6,775,647

G

X-box binding protein 1

increases expression

Curcumin results in increased expression of XBP1 mRNA

NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597

G

xanthine dehydrogenase

multiple interactions

Curcumin inhibits the reaction [Indomethacin results in increased activity of XDH protein]

NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742

G

X-linked inhibitor of apoptosis

multiple interactions
decreases expression

[Arsenic Trioxide co-treated with Curcumin] results in decreased expression of XIAP protein; [Curcumin co-treated with Doxorubicin] affects the expression of XIAP mRNA; Arsenic Trioxide promotes the reaction [Curcumin results in decreased expression of XIAP protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of XIAP protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of XIAP protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; Curcumin promotes the reaction [lonidamine results in decreased expression of XIAP protein]; lonidamine promotes the reaction [Curcumin results in decreased expression of XIAP protein]
Curcumin analog results in decreased expression of XIAP mRNA; Curcumin results in decreased expression of XIAP mRNA; Curcumin results in decreased expression of XIAP protein

PMID:15911101 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 More...

NCBI chr X:123,859,708...123,913,972
Ensembl chr X:123,859,712...123,913,972

G

exportin 1

multiple interactions

Curcumin inhibits the reaction [KRAS protein results in decreased expression of XPO1 protein]

NCBI chr 2:61,477,849...61,538,612
Ensembl chr 2:61,476,032...61,538,741

G

X-ray repair cross complementing 1

multiple interactions

Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC1 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC1 protein]

NCBI chr19:43,543,311...43,575,527
Ensembl chr19:43,543,311...43,580,473

G

X-ray repair cross complementing 4

multiple interactions

Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 protein]

NCBI chr 5:83,077,547...83,374,473
Ensembl chr 5:83,077,498...83,353,787

G

X-ray repair cross complementing 5

decreases expression

Curcumin results in decreased expression of XRCC5 mRNA

NCBI chr 2:216,109,348...216,206,293
Ensembl chr 2:216,107,464...216,206,303

G

X-ray repair cross complementing 6

decreases expression

Curcumin results in decreased expression of XRCC6 mRNA

NCBI chr22:41,621,295...41,664,041
Ensembl chr22:41,621,163...41,664,048

G

yippee like 3

decreases expression

Curcumin results in decreased expression of YPEL3 mRNA

NCBI chr16:30,092,314...30,096,213
Ensembl chr16:30,092,314...30,096,915

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

decreases expression

Curcumin results in decreased expression of YWHAE mRNA; Curcumin results in decreased expression of YWHAE protein

NCBI chr17:1,344,275...1,400,222
Ensembl chr17:1,344,275...1,400,222

G

zinc finger homeobox 3

decreases expression

Curcumin results in decreased expression of ZFHX3 mRNA

NCBI chr16:72,782,885...73,891,930
Ensembl chr16:72,782,885...73,891,871

G

ZFP36 ring finger protein like 1

decreases expression

Curcumin results in decreased expression of ZFP36L1 mRNA

NCBI chr14:68,787,655...68,796,243
Ensembl chr14:68,787,660...68,796,253

G

zinc finger protein 287

increases expression

Curcumin results in increased expression of ZNF287 mRNA

NCBI chr17:16,546,954...16,569,212
Ensembl chr17:16,546,954...16,569,204

G

zinc finger protein 589

decreases expression

Curcumin results in decreased expression of ZNF589 mRNA

NCBI chr 3:48,241,104...48,270,990
Ensembl chr 3:48,241,100...48,299,253

G

zinc finger protein 823

increases expression

Curcumin results in increased expression of ZNF823 mRNA

NCBI chr19:11,721,265...11,738,946
Ensembl chr19:11,721,265...11,739,009

demethoxycurcumin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

decreases activity

demethoxycurcumin results in decreased activity of ABCC1 protein

PMID:15885658 PMID:16021489

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

G

ATP binding cassette subfamily C member 2

decreases activity

demethoxycurcumin results in decreased activity of ABCC2 protein

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

acetylcholinesterase (Yt blood group)

decreases activity

demethoxycurcumin results in decreased activity of ACHE protein

NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

demethoxycurcumin results in increased phosphorylation of AKT1 protein
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]
AKT1 protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]

PMID:17535857 PMID:35752269

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

amyloid beta precursor protein

multiple interactions
decreases secretion

demethoxycurcumin inhibits the reaction [APP protein binds to APP protein]
demethoxycurcumin results in decreased secretion of APP protein

NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128

G

activating transcription factor 6

multiple interactions

demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]

NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574

G

BCL2 antagonist/killer 1

decreases expression

demethoxycurcumin results in decreased expression of BAK1 mRNA

NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293

G

BCL2 associated X, apoptosis regulator

increases expression

demethoxycurcumin results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression

demethoxycurcumin results in decreased expression of BCL2 protein

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

decreases expression

demethoxycurcumin results in decreased expression of BCL2L1 mRNA; demethoxycurcumin results in decreased expression of BCL2L1 protein

PMID:33582110 PMID:34291863

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

baculoviral IAP repeat containing 5

decreases expression

demethoxycurcumin results in decreased expression of BIRC5 protein

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

caspase 12 (gene/pseudogene)

multiple interactions

demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of CASP12 protein modified form]

NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670

G

caspase 3

multiple interactions
increases cleavage
decreases expression

demethoxycurcumin inhibits the reaction [Peroxynitrous Acid results in increased activity of CASP3 protein]
demethoxycurcumin results in increased cleavage of CASP3 protein
demethoxycurcumin results in decreased expression of CASP3 mRNA

PMID:19188863 PMID:33582110 PMID:34291863

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

decreases expression

demethoxycurcumin results in decreased expression of CASP8 mRNA

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

increases activity
increases cleavage
decreases expression

demethoxycurcumin results in increased activity of CASP9 protein
demethoxycurcumin results in increased cleavage of CASP9 protein
demethoxycurcumin results in decreased expression of CASP9 mRNA

PMID:33582110 PMID:34291863

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

CD36 molecule (CD36 blood group)

multiple interactions

demethoxycurcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; demethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; demethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein]

NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277

G

cyclin dependent kinase 4

decreases expression

demethoxycurcumin results in decreased expression of CDK4 protein

NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013

G

cyclin dependent kinase inhibitor 1A

increases expression

demethoxycurcumin results in increased expression of CDKN1A mRNA

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337

G

DNA damage inducible transcript 3

multiple interactions

demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518

G

erb-b2 receptor tyrosine kinase 2

multiple interactions
increases response to substance

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [demethoxycurcumin results in increased degradation of ERBB2 protein]; demethoxycurcumin results in decreased expression of and results in increased degradation of ERBB2 protein
ERBB2 protein results in increased susceptibility to demethoxycurcumin

NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]

NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819

G

growth arrest and DNA damage inducible alpha

increases expression

demethoxycurcumin results in increased expression of GADD45A mRNA

NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334

G

glutamate-cysteine ligase modifier subunit

increases expression

demethoxycurcumin results in increased expression of GCLM mRNA
demethoxycurcumin results in increased expression of GCLM mRNA; demethoxycurcumin results in increased expression of GCLM protein

PMID:17535857 PMID:19188863 PMID:23386263

NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456

G

heme oxygenase 1

multiple interactions
increases expression

[demethoxycurcumin co-treated with bisdemethoxycurcumin] results in increased expression of HMOX1 mRNA; AKT1 protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; KEAP1 protein inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; PRKCD protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein]
demethoxycurcumin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of HMOX1 mRNA]
demethoxycurcumin results in increased expression of HMOX1 mRNA; demethoxycurcumin results in increased expression of HMOX1 protein

PMID:17535857 PMID:19188863 PMID:23386263

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

heat shock protein family A (Hsp70) member 5

multiple interactions

demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

insulin

increases secretion

demethoxycurcumin results in increased secretion of INS protein

NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221

G

kinase insert domain receptor

affects expression
multiple interactions

demethoxycurcumin affects the expression of KDR mRNA
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]

PMID:17960570 PMID:35752269

NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595

G

kelch like ECH associated protein 1

multiple interactions

KEAP1 protein inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]

NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558

G

mitogen-activated protein kinase 1

increases phosphorylation
multiple interactions

demethoxycurcumin results in increased phosphorylation of MAPK1 protein
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]

PMID:17535857 PMID:35752269

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

increases phosphorylation
multiple interactions

demethoxycurcumin results in increased phosphorylation of MAPK3 protein
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]

PMID:17535857 PMID:35752269

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

matrix metallopeptidase 14

decreases expression

demethoxycurcumin results in decreased expression of MMP14 protein

NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,041

G

matrix metallopeptidase 2

multiple interactions

demethoxycurcumin results in decreased secretion of and results in decreased activity of MMP2 protein modified form

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 9

multiple interactions

demethoxycurcumin results in decreased secretion of and results in decreased activity of MMP9 protein

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

macrophage scavenger receptor 1

multiple interactions

demethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]

NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490

G

NFE2 like bZIP transcription factor 2

affects localization
multiple interactions

demethoxycurcumin affects the localization of NFE2L2 protein
[demethoxycurcumin co-treated with bisdemethoxycurcumin] affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

NFKB inhibitor alpha

multiple interactions

demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

nitric oxide synthase 2

multiple interactions

demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:18449507 PMID:18838107

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

NAD(P)H quinone dehydrogenase 1

increases expression

demethoxycurcumin results in increased expression of NQO1 mRNA; demethoxycurcumin results in increased expression of NQO1 protein

PMID:17535857 PMID:19188863

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

oxidized low density lipoprotein receptor 1

multiple interactions

demethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OLR1 mRNA]

NCBI chr12:10,158,301...10,176,266
Ensembl chr12:10,158,301...10,172,138

G

poly(ADP-ribose) polymerase 1

increases cleavage
multiple interactions

demethoxycurcumin results in increased cleavage of PARP1 protein
Wortmannin promotes the reaction [demethoxycurcumin results in increased cleavage of PARP1 protein]

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

platelet and endothelial cell adhesion molecule 1

increases expression

demethoxycurcumin results in increased expression of PECAM1 protein

NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776

G

plasminogen activator, urokinase

decreases secretion

demethoxycurcumin results in decreased secretion of PLAU protein

NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496

G

peroxisome proliferator activated receptor gamma

affects binding

demethoxycurcumin binds to PPARG protein

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

protein kinase C delta

multiple interactions

PRKCD protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]

NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717

G

prostaglandin-endoperoxide synthase 2

multiple interactions

demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases expression

demethoxycurcumin results in decreased expression of RAF1 protein

NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201

G

TIMP metallopeptidase inhibitor 2

decreases expression

demethoxycurcumin results in decreased expression of TIMP2 protein

NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387

G

tumor necrosis factor

multiple interactions

demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

vascular endothelial growth factor A

affects expression
multiple interactions

demethoxycurcumin affects the expression of VEGFA mRNA
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]

PMID:17960570 PMID:35752269

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

G

WT1 transcription factor

decreases expression

demethoxycurcumin results in decreased expression of WT1 mRNA; demethoxycurcumin results in decreased expression of WT1 protein

NCBI chr11:32,387,775...32,435,539
Ensembl chr11:32,387,775...32,435,564

G

X-linked inhibitor of apoptosis

decreases expression

demethoxycurcumin results in decreased expression of XIAP protein

NCBI chr X:123,859,708...123,913,972
Ensembl chr X:123,859,712...123,913,972

dibenzoylmethane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2 (JR blood group)

increases expression

dibenzoylmethane results in increased expression of ABCG2 protein

NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

dibenzoylmethane results in decreased phosphorylation of AKT1 protein
[dibenzoylmethane co-treated with sulforaphane] results in decreased phosphorylation of AKT1 protein

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

BCL2 associated agonist of cell death

multiple interactions
increases expression

ODC1 protein inhibits the reaction [dibenzoylmethane results in increased expression of BAD protein]

NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704

G

BCL2 associated X, apoptosis regulator

increases expression

dibenzoylmethane results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

multiple interactions

dibenzoylmethane inhibits the reaction [ESR1 protein binds to BCL2 enhancer]; dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA]

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

caspase 9

multiple interactions

ODC1 protein inhibits the reaction [dibenzoylmethane results in increased activity of CASP9 protein]

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

carbonyl reductase 3

increases expression
multiple interactions

dibenzoylmethane results in increased expression of CBR3 mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of CBR3 mRNA

NCBI chr21:36,135,079...36,146,562
Ensembl chr21:36,135,079...36,146,562

G

cyclin D1

decreases expression

dibenzoylmethane results in decreased expression of CCND1 protein

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cyclin dependent kinase inhibitor 1A

decreases expression

dibenzoylmethane results in decreased expression of CDKN1A protein

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337

G

clusterin

decreases expression
multiple interactions

dibenzoylmethane results in decreased expression of CLU mRNA
[sulforaphane co-treated with dibenzoylmethane] results in decreased expression of CLU mRNA

NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700

G

epoxide hydrolase 1

increases activity
multiple interactions
increases expression

dibenzoylmethane results in increased activity of EPHX1 protein
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of EPHX1 mRNA
dibenzoylmethane results in increased expression of EPHX1 mRNA

PMID:3621371 PMID:17942926

NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563

G

estrogen receptor 1

multiple interactions

dibenzoylmethane inhibits the reaction [ESR1 protein binds to BCL2 enhancer]; dibenzoylmethane inhibits the reaction [ESR1 protein binds to MYC enhancer]; dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer]

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

glutamate-cysteine ligase catalytic subunit

increases expression
multiple interactions

dibenzoylmethane results in increased expression of GCLC mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of GCLC mRNA

NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970

G

glutathione S-transferase mu 1

increases expression
multiple interactions

dibenzoylmethane results in increased expression of GSTM1 mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of GSTM1 mRNA

NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039

G

glutathione S-transferase mu 3

multiple interactions
increases expression

[sulforaphane co-treated with dibenzoylmethane] results in increased expression of GSTM3 mRNA
dibenzoylmethane results in increased expression of GSTM3 mRNA

NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038

G

HRas proto-oncogene, GTPase

multiple interactions

dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of HRAS mRNA]

NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

dibenzoylmethane inhibits the reaction [ESR1 protein binds to MYC enhancer]

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

ornithine decarboxylase 1

multiple interactions
decreases response to substance

ODC1 protein inhibits the reaction [dibenzoylmethane results in increased abundance of Reactive Oxygen Species]; ODC1 protein inhibits the reaction [dibenzoylmethane results in increased activity of CASP9 protein]; ODC1 protein inhibits the reaction [dibenzoylmethane results in increased expression of BAD protein]
ODC1 protein results in decreased susceptibility to dibenzoylmethane

NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327

G

prostaglandin reductase 1

multiple interactions

[sulforaphane co-treated with dibenzoylmethane] results in increased expression of PTGR1 mRNA

NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893

G

prostaglandin-endoperoxide synthase 2

decreases expression

dibenzoylmethane results in decreased expression of PTGS2 protein

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

telomerase reverse transcriptase

multiple interactions

dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer]; dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of TERT mRNA]

NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068

hexane-2,3-dione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1 member A1

increases reduction

AKR1A1 protein results in increased reduction of 2,3-hexanedione

NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049

G

aldo-keto reductase family 1 member B

increases reduction
multiple interactions

AKR1B1 protein results in increased reduction of 2,3-hexanedione
[AKR1B1 protein results in increased reduction of 2,3-hexanedione] which results in increased chemical synthesis of Hexanones

PMID:10510318 PMID:23295224

NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284

G

aldo-keto reductase family 1 member B10

increases reduction
multiple interactions

AKR1B10 protein results in increased reduction of 2,3-hexanedione
[AKR1B10 protein results in increased reduction of 2,3-hexanedione] which results in increased chemical synthesis of Hexanones

NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412

G

carbonyl reductase 1

increases reduction
multiple interactions

CBR1 protein results in increased reduction of 2,3-hexanedione
8-prenylnaringenin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 2,3-hexanedione]; Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; isoxanthohumol inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; Quercetin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; xanthohumol inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]

PMID:23295225 PMID:25541467 PMID:30849340

NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166

ninhydrin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tumor protein p53

affects activity

Ninhydrin affects the activity of TP53 protein

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

oligomycin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase H+ transporting V1 subunit H

multiple interactions

[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA

NCBI chr 8:53,715,543...53,843,245
Ensembl chr 8:53,715,543...53,843,558

G

BCL2 apoptosis regulator

multiple interactions

oligomycin A inhibits the reaction [bisphenol A results in increased expression of BCL2 protein]

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

cyclin A2

multiple interactions

oligomycin A inhibits the reaction [bisphenol A results in increased expression of CCNA2 protein]

NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883

G

cyclin B1

multiple interactions

oligomycin A inhibits the reaction [bisphenol A results in increased expression of CCNB1 protein]

NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245

G

cyclin D1

multiple interactions

[bisphenol A co-treated with oligomycin A] results in decreased expression of CCND1 protein

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cyclin E1

multiple interactions

[bisphenol A co-treated with oligomycin A] results in decreased expression of CCNE1 protein

NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312

G

CD14 molecule

increases expression

oligomycin A results in increased expression of CD14 protein

NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700

G

fucosyltransferase 4

increases expression

oligomycin A results in increased expression of FUT4 protein

NCBI chr11:94,543,921...94,549,895
Ensembl chr11:94,543,921...94,549,895

G

lysosomal associated membrane protein 1

multiple interactions

[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA

NCBI chr13:113,297,239...113,323,672
Ensembl chr13:113,297,239...113,323,672

G

PTEN induced kinase 1

multiple interactions

[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein]; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA]; PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]]

NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

[oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein]

NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775

G

sequestosome 1

multiple interactions

[oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA]

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

transcription factor EB

multiple interactions

[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]]

NCBI chr 6:41,683,978...41,736,223
Ensembl chr 6:41,683,978...41,736,259

pentane-2,3-dione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ADAM metallopeptidase domain 10

increases expression

2,3-pentanedione results in increased expression of ADAM10 mRNA

NCBI chr15:58,588,809...58,749,707
Ensembl chr15:58,588,809...58,749,791

G

ADAM metallopeptidase domain 19

increases expression

2,3-pentanedione results in increased expression of ADAM19 mRNA

NCBI chr 5:157,477,304...157,575,775
Ensembl chr 5:157,395,534...157,575,775

G

ADAM metallopeptidase domain 8

decreases expression

2,3-pentanedione results in decreased expression of ADAM8 mRNA

NCBI chr10:133,262,423...133,276,868
Ensembl chr10:133,262,420...133,276,868

G

A-kinase anchoring protein 5

increases expression

2,3-pentanedione results in increased expression of AKAP5 mRNA

NCBI chr14:64,465,499...64,474,503
Ensembl chr14:64,465,499...64,474,503

G

aldo-keto reductase family 1 member B

increases reduction
multiple interactions

AKR1B1 protein results in increased reduction of 2,3-pentanedione
[AKR1B1 protein results in increased reduction of 2,3-pentanedione] which results in increased chemical synthesis of Pentanones

NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284

G

aldo-keto reductase family 1 member B10

increases reduction
multiple interactions

AKR1B10 protein results in increased reduction of 2,3-pentanedione
[AKR1B10 protein results in increased reduction of 2,3-pentanedione] which results in increased chemical synthesis of Pentanones

NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412

G

aldehyde dehydrogenase 1 family member A3

increases expression

2,3-pentanedione results in increased expression of ALDH1A3 mRNA

NCBI chr15:100,879,831...100,916,626
Ensembl chr15:100,877,714...100,916,626

G

angiopoietin like 4

increases expression

2,3-pentanedione results in increased expression of ANGPTL4 mRNA

NCBI chr19:8,364,155...8,374,370
Ensembl chr19:8,363,289...8,374,370

G

apelin

increases expression

2,3-pentanedione results in increased expression of APLN mRNA

NCBI chr X:129,645,259...129,654,956
Ensembl chr X:129,645,259...129,654,956

G

Rho GTPase activating protein 17

increases expression

2,3-pentanedione results in increased expression of ARHGAP17 mRNA

NCBI chr16:24,919,389...25,015,369
Ensembl chr16:24,919,389...25,015,666

G

branched chain amino acid transaminase 1

increases expression

2,3-pentanedione results in increased expression of BCAT1 mRNA

NCBI chr12:24,810,024...24,949,340
Ensembl chr12:24,810,024...24,949,101

G

bone morphogenetic protein 3

decreases expression

2,3-pentanedione results in decreased expression of BMP3 mRNA

NCBI chr 4:81,030,708...81,057,627
Ensembl chr 4:81,030,708...81,057,627

G

complement C9

decreases expression

2,3-pentanedione results in decreased expression of C9 mRNA

NCBI chr 5:39,284,140...39,364,495
Ensembl chr 5:39,284,140...39,371,324

G

coiled-coil and C2 domain containing 2A

decreases expression

2,3-pentanedione results in decreased expression of CC2D2A mRNA

NCBI chr 4:15,469,865...15,601,557
Ensembl chr 4:15,469,865...15,601,552

G

cellular communication network factor 2

increases expression

2,3-pentanedione results in increased expression of CCN2 mRNA

NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372

G

cellular communication network factor 4

increases expression

2,3-pentanedione results in increased expression of CCN4 mRNA

NCBI chr 8:133,191,039...133,231,690
Ensembl chr 8:133,191,039...133,231,690

G

CD36 molecule (CD36 blood group)

increases expression

2,3-pentanedione results in increased expression of CD36 mRNA

NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277

G

cell division cycle 20B

decreases expression

2,3-pentanedione results in decreased expression of CDC20B mRNA

NCBI chr 5:55,112,971...55,173,177
Ensembl chr 5:55,112,971...55,173,177

G

cadherin related family member 4

decreases expression

2,3-pentanedione results in decreased expression of CDHR4 mRNA

NCBI chr 3:49,790,732...49,802,914
Ensembl chr 3:49,790,732...49,799,873

G

carboxylesterase 1

decreases expression

2,3-pentanedione results in decreased expression of CES1D mRNA

NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337

G

cilia and flagella associated protein 221

decreases expression

2,3-pentanedione results in decreased expression of CFAP221 mRNA

NCBI chr 2:119,544,449...119,660,323
Ensembl chr 2:119,544,432...119,662,251

G

cilia and flagella associated protein 70

decreases expression

2,3-pentanedione results in decreased expression of CFAP70 mRNA

NCBI chr10:73,253,762...73,362,979
Ensembl chr10:73,253,762...73,358,864

G

claudin 18

increases expression

2,3-pentanedione results in increased expression of CLDN18 mRNA

NCBI chr 3:137,998,816...138,033,649
Ensembl chr 3:137,998,735...138,033,655

G

chloride intracellular channel 5

increases expression

2,3-pentanedione results in increased expression of CLIC5 mRNA

NCBI chr 6:45,880,827...46,129,819
Ensembl chr 6:45,880,827...46,080,348

G

chymase 1

increases expression

2,3-pentanedione results in increased expression of CMA1 mRNA

NCBI chr14:24,505,353...24,508,265
Ensembl chr14:24,505,353...24,508,265

G

collagen type XII alpha 1 chain

increases expression

2,3-pentanedione results in increased expression of COL12A1 mRNA

NCBI chr 6:75,084,326...75,206,053
Ensembl chr 6:75,084,326...75,206,267

G

collagen type XIII alpha 1 chain

decreases expression

2,3-pentanedione results in decreased expression of COL13A1 mRNA

NCBI chr10:69,801,906...69,959,144
Ensembl chr10:69,801,880...69,964,275

G

collagen type XIV alpha 1 chain

increases expression

2,3-pentanedione results in increased expression of COL14A1 mRNA

NCBI chr 8:120,124,454...120,373,573
Ensembl chr 8:120,059,780...120,373,573

G

collagen type XVIII alpha 1 chain

increases expression

2,3-pentanedione results in increased expression of COL18A1 mRNA

NCBI chr21:45,405,165...45,513,720
Ensembl chr21:45,405,165...45,513,720

G

collagen type I alpha 2 chain

increases expression

2,3-pentanedione results in increased expression of COL1A2 mRNA

NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227

G

collagen type IV alpha 1 chain

increases expression

2,3-pentanedione results in increased expression of COL4A1 mRNA

NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,157

G

collagen type V alpha 1 chain

increases expression

2,3-pentanedione results in increased expression of COL5A1 mRNA

NCBI chr 9:134,641,803...134,844,843
Ensembl chr 9:134,641,803...134,844,843

G

collagen type V alpha 2 chain

increases expression

2,3-pentanedione results in increased expression of COL5A2 mRNA

NCBI chr 2:189,031,898...189,441,111
Ensembl chr 2:189,031,898...189,225,312

G

collagen type V alpha 3 chain

increases expression

2,3-pentanedione results in increased expression of COL5A3 mRNA

NCBI chr19:9,959,561...10,010,504
Ensembl chr19:9,959,561...10,010,504

G

collagen type VI alpha 2 chain

increases expression

2,3-pentanedione results in increased expression of COL6A2 mRNA

NCBI chr21:46,098,112...46,132,848
Ensembl chr21:46,098,112...46,132,848

G

carboxypeptidase X, M14 family member 2

decreases expression

2,3-pentanedione results in decreased expression of CPXM2 mRNA

NCBI chr10:123,745,639...123,944,104
Ensembl chr10:123,706,207...123,940,267

G

cellular retinoic acid binding protein 2

increases expression

2,3-pentanedione results in increased expression of CRABP2 mRNA

NCBI chr 1:156,699,606...156,705,784
Ensembl chr 1:156,699,606...156,705,816

G

colony stimulating factor 3

decreases expression

2,3-pentanedione results in decreased expression of CSF3 mRNA

NCBI chr17:40,015,440...40,017,813
Ensembl chr17:40,015,361...40,017,813

G

collagen triple helix repeat containing 1

increases expression

2,3-pentanedione results in increased expression of CTHRC1 mRNA

NCBI chr 8:103,371,538...103,382,989
Ensembl chr 8:103,371,538...103,382,989

G

C-X3-C motif chemokine receptor 1

increases expression

2,3-pentanedione results in increased expression of CX3CR1 mRNA

NCBI chr 3:39,263,494...39,292,966
Ensembl chr 3:39,263,495...39,281,735

G

C-X-C motif chemokine ligand 1

decreases expression

2,3-pentanedione results in decreased expression of CXCL1 mRNA
2,3-pentanedione results in decreased expression of CXCL3 mRNA

NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308

G

C-X-C motif chemokine receptor 4

decreases expression
increases expression

2,3-pentanedione results in decreased expression of CXCR4 mRNA
2,3-pentanedione results in increased expression of CXCR4 mRNA

NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177

G

cytochrome P450 family 2 subfamily A member 7

decreases expression

2,3-pentanedione results in decreased expression of CYP2A3 mRNA

NCBI chr19:40,875,439...40,882,231
Ensembl chr19:40,875,439...40,882,752

G

cytochrome P450 family 2 subfamily F member 1

decreases expression

2,3-pentanedione results in decreased expression of CYP2F4 mRNA

NCBI chr19:41,114,432...41,128,381
Ensembl chr19:41,114,432...41,128,381

G

cytochrome P450 family 4 subfamily B member 1

decreases expression

2,3-pentanedione results in decreased expression of CYP4B1 mRNA

NCBI chr 1:46,799,046...46,819,413
Ensembl chr 1:46,757,838...46,819,413

G

dehydrogenase/reductase 9

increases expression

2,3-pentanedione results in increased expression of DHRS9 mRNA

NCBI chr 2:169,067,077...169,096,167
Ensembl chr 2:169,064,789...169,096,167

G

doublesex and mab-3 related transcription factor 2

decreases expression

2,3-pentanedione results in decreased expression of DMRT2 mRNA

NCBI chr 9:1,050,357...1,057,552
Ensembl chr 9:1,049,858...1,057,552

G

dynein axonemal assembly factor 1

decreases expression

2,3-pentanedione results in decreased expression of DNAAF1 mRNA

NCBI chr16:84,145,308...84,177,920
Ensembl chr16:84,145,287...84,178,767

G

dynein axonemal heavy chain 12

decreases expression

2,3-pentanedione results in decreased expression of DNAH12 mRNA

NCBI chr 3:57,293,700...57,556,034
Ensembl chr 3:57,293,699...57,544,344

G

dynein axonemal heavy chain 3

decreases expression

2,3-pentanedione results in decreased expression of DNAH3 mRNA

NCBI chr16:20,933,111...21,159,459
Ensembl chr16:20,933,111...21,159,441

G

dynein axonemal heavy chain 6

decreases expression

2,3-pentanedione results in decreased expression of DNAH6 mRNA

NCBI chr 2:84,459,572...84,819,589
Ensembl chr 2:84,516,455...84,819,589

G

dynein axonemal intermediate chain 1

decreases expression

2,3-pentanedione results in decreased expression of DNAI1 mRNA

NCBI chr 9:34,458,805...34,520,984
Ensembl chr 9:34,457,414...34,520,988

G

epidermal growth factor receptor

increases expression

2,3-pentanedione results in increased expression of EGFR mRNA

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

early growth response 2

increases expression

2,3-pentanedione results in increased expression of EGR2 mRNA

NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,819,167

G

fibulin 1

decreases expression

2,3-pentanedione results in decreased expression of FBLN1 mRNA

NCBI chr22:45,502,883...45,601,135
Ensembl chr22:45,502,238...45,601,135

G

fibrillin 1

increases expression

2,3-pentanedione results in increased expression of FBN1 mRNA

NCBI chr15:48,408,313...48,645,709
Ensembl chr15:48,408,313...48,645,721

G

fibroblast growth factor receptor 2

decreases expression

2,3-pentanedione results in decreased expression of FGFR2 mRNA

NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458

G

fibroblast growth factor receptor 3

decreases expression

2,3-pentanedione results in decreased expression of FGFR3 mRNA

NCBI chr 4:1,793,293...1,808,867
Ensembl chr 4:1,793,293...1,808,872

G

flavin containing dimethylaniline monoxygenase 2

decreases expression

2,3-pentanedione results in decreased expression of FMO2 mRNA

NCBI chr 1:171,185,208...171,212,686
Ensembl chr 1:171,185,249...171,212,686

G

fibronectin 1

increases expression

2,3-pentanedione results in increased expression of FN1 mRNA

NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073

G

fibronectin type III domain containing 3B

decreases expression

2,3-pentanedione results in decreased expression of FNDC3B mRNA

NCBI chr 3:172,039,578...172,401,669
Ensembl chr 3:172,039,578...172,401,669

G

glutamate decarboxylase 1

decreases expression

2,3-pentanedione results in decreased expression of GAD1 mRNA

NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151

G

growth arrest specific 6

increases expression

2,3-pentanedione results in increased expression of GAS6 mRNA

NCBI chr13:113,820,549...113,864,076
Ensembl chr13:113,820,549...113,864,076

G

growth hormone inducible transmembrane protein

decreases expression

2,3-pentanedione results in decreased expression of GHITM mRNA

NCBI chr10:84,139,509...84,153,568
Ensembl chr10:84,139,482...84,154,841

G

G protein-coupled receptor 155

decreases expression

2,3-pentanedione results in decreased expression of GPR155 mRNA

NCBI chr 2:174,431,571...174,487,029
Ensembl chr 2:174,431,571...174,487,094

G

glutathione peroxidase 2

increases expression

2,3-pentanedione results in increased expression of GPX2 mRNA

NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746

G

growth factor receptor bound protein 10

increases expression

2,3-pentanedione results in increased expression of GRB10 mRNA

NCBI chr 7:50,590,068...50,793,453
Ensembl chr 7:50,590,063...50,793,462

G

glutathione S-transferase alpha 5

decreases expression

2,3-pentanedione results in decreased expression of GSTA5 mRNA

NCBI chr 6:52,831,692...52,846,245
Ensembl chr 6:52,831,655...52,840,843

G

huntingtin associated protein 1

decreases expression

2,3-pentanedione results in decreased expression of HAP1 mRNA

NCBI chr17:41,717,739...41,734,646
Ensembl chr17:41,717,742...41,734,644

G

hyaluronan synthase 2

increases expression

2,3-pentanedione results in increased expression of HAS2 mRNA

NCBI chr 8:121,612,116...121,641,440
Ensembl chr 8:121,612,116...121,641,440

G

heparin binding EGF like growth factor

increases expression

2,3-pentanedione results in increased expression of HBEGF mRNA

NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603

G

histone deacetylase 10

increases expression

2,3-pentanedione results in increased expression of HDAC10 mRNA

NCBI chr22:50,245,183...50,251,265
Ensembl chr22:50,245,183...50,251,405

G

insulin like growth factor 1

increases expression

2,3-pentanedione results in increased expression of IGF1 mRNA

NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744

G

insulin like growth factor 2 mRNA binding protein 2

increases expression

2,3-pentanedione results in increased expression of IGF2BP2 mRNA

NCBI chr 3:185,643,130...185,825,042
Ensembl chr 3:185,643,130...185,825,042

G

insulin like growth factor binding protein 4

increases expression

2,3-pentanedione results in increased expression of IGFBP4 mRNA

NCBI chr17:40,443,450...40,457,725
Ensembl chr17:40,443,450...40,457,725

G

insulin like growth factor binding protein 5

decreases expression

2,3-pentanedione results in decreased expression of IGFBP5 mRNA

NCBI chr 2:216,672,105...216,695,549
Ensembl chr 2:216,672,105...216,695,549

G

interleukin 18

increases expression

2,3-pentanedione results in increased expression of IL18 mRNA

NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096

G

interleukin 1 alpha

increases expression

2,3-pentanedione results in increased expression of IL1A mRNA

NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493

G

interleukin 1 receptor antagonist

increases expression

2,3-pentanedione results in increased expression of IL1RN mRNA

NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016

G

interleukin 24

increases expression

2,3-pentanedione results in increased expression of IL24 mRNA

NCBI chr 1:206,897,443...206,904,139
Ensembl chr 1:206,897,443...206,904,139

G

interleukin 33

increases expression
decreases expression

2,3-pentanedione results in increased expression of IL33 mRNA
2,3-pentanedione results in decreased expression of IL33 mRNA

PMID:25710175 PMID:30710127

NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983

G

inhibin subunit beta A

increases expression

2,3-pentanedione results in increased expression of INHBA mRNA

NCBI chr 7:41,685,114...41,705,406
Ensembl chr 7:41,667,168...41,705,834

G

interleukin 1 receptor associated kinase 1 binding protein 1

decreases expression

2,3-pentanedione results in decreased expression of IRAK1BP1 mRNA

NCBI chr 6:78,867,551...78,979,411
Ensembl chr 6:78,867,551...78,946,440

G

integrin subunit alpha 5

increases expression

2,3-pentanedione results in increased expression of ITGA5 mRNA

NCBI chr12:54,395,261...54,419,266
Ensembl chr12:54,395,261...54,419,266

G

integrin subunit alpha 6

increases expression

2,3-pentanedione results in increased expression of ITGA6 mRNA

NCBI chr 2:172,427,336...172,506,459
Ensembl chr 2:172,427,354...172,506,459

G

integrin subunit beta 1

increases expression

2,3-pentanedione results in increased expression of ITGB1 mRNA

NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792

G

integrin subunit beta 3

increases expression

2,3-pentanedione results in increased expression of ITGB3 mRNA

NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,827...47,313,743

G

kelch like family member 38

decreases expression

2,3-pentanedione results in decreased expression of KLHL38 mRNA

NCBI chr 8:123,644,442...123,653,801
Ensembl chr 8:123,644,442...123,653,801

G

keratin 13

increases expression

2,3-pentanedione results in increased expression of KRT13 mRNA

NCBI chr17:41,500,981...41,505,612
Ensembl chr17:41,500,981...41,505,705

G

keratin 14

increases expression

2,3-pentanedione results in increased expression of KRT14 mRNA

NCBI chr17:41,582,279...41,586,895
Ensembl chr17:41,582,279...41,586,895

G

keratin 16

increases expression

2,3-pentanedione results in increased expression of KRT16 mRNA

NCBI chr17:41,609,778...41,612,767
Ensembl chr17:41,609,778...41,615,899

G

keratin 4

increases expression

2,3-pentanedione results in increased expression of KRT4 mRNA

NCBI chr12:52,806,549...52,814,116
Ensembl chr12:52,806,549...52,814,116

G

laminin subunit beta 3

increases expression

2,3-pentanedione results in increased expression of LAMB3 mRNA

NCBI chr 1:209,614,870...209,652,425
Ensembl chr 1:209,614,870...209,652,425

G

laminin subunit gamma 2

increases expression

2,3-pentanedione results in increased expression of LAMC2 mRNA

NCBI chr 1:183,186,264...183,258,968
Ensembl chr 1:183,186,238...183,245,127

G

laminin subunit gamma 3

decreases expression

2,3-pentanedione results in decreased expression of LAMC3 mRNA

NCBI chr 9:131,009,174...131,094,473
Ensembl chr 9:131,009,174...131,094,473

G

leucine rich glioma inactivated 1

decreases expression

2,3-pentanedione results in decreased expression of LGI1 mRNA

NCBI chr10:93,757,936...93,798,159
Ensembl chr10:93,757,840...93,806,272

G

lysyl oxidase

increases expression

2,3-pentanedione results in increased expression of LOX mRNA

NCBI chr 5:122,063,195...122,078,259
Ensembl chr 5:122,063,195...122,078,413

G

lysyl oxidase like 2

increases expression

2,3-pentanedione results in increased expression of LOXL2 mRNA

NCBI chr 8:23,296,897...23,404,120
Ensembl chr 8:23,296,897...23,425,328

G

LDL receptor related protein 10

increases expression

2,3-pentanedione results in increased expression of LRP10 mRNA

NCBI chr14:22,871,740...22,881,713
Ensembl chr14:22,871,740...22,881,713

G

MIR205 host gene

decreases expression

2,3-pentanedione results in decreased expression of MIR205HG mRNA

NCBI chr 1:209,428,820...209,432,549
Ensembl chr 1:209,428,817...209,432,848

G

matrix metallopeptidase 14

increases expression

2,3-pentanedione results in increased expression of MMP14 mRNA

NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,041

G

matrix metallopeptidase 2

increases expression

2,3-pentanedione results in increased expression of MMP2 mRNA

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 24

decreases expression

2,3-pentanedione results in decreased expression of MMP24 mRNA

NCBI chr20:35,226,690...35,276,998
Ensembl chr20:35,226,690...35,276,998

G

nerve growth factor

increases expression

2,3-pentanedione results in increased expression of NGF mRNA

NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770

G

sodium/potassium transporting ATPase interacting 1

increases expression

2,3-pentanedione results in increased expression of NKAIN1 mRNA

NCBI chr 1:31,179,745...31,239,887
Ensembl chr 1:31,179,745...31,239,887

G

noggin

increases expression

2,3-pentanedione results in increased expression of NOG mRNA

NCBI chr17:56,593,699...56,595,611
Ensembl chr17:56,593,699...56,595,611

G

neuregulin 1

increases expression

2,3-pentanedione results in increased expression of NRG1 mRNA

NCBI chr 8:31,639,245...32,774,046
Ensembl chr 8:31,639,222...32,855,666

G

3'-phosphoadenosine 5'-phosphosulfate synthase 2

decreases expression

2,3-pentanedione results in decreased expression of PAPSS2 mRNA

NCBI chr10:87,659,878...87,747,705
Ensembl chr10:87,659,613...87,747,705

G

platelet derived growth factor receptor beta

increases expression

2,3-pentanedione results in increased expression of PDGFRB mRNA

NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872

G

plasminogen activator, tissue type

increases expression

2,3-pentanedione results in increased expression of PLAT mRNA

NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709

G

plasminogen activator, urokinase

increases expression

2,3-pentanedione results in increased expression of PLAU mRNA

NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496

G

plasminogen activator, urokinase receptor

increases expression

2,3-pentanedione results in increased expression of PLAUR mRNA

NCBI chr19:43,646,095...43,670,169
Ensembl chr19:43,646,095...43,670,547

G

procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

increases expression

2,3-pentanedione results in increased expression of PLOD2 mRNA

NCBI chr 3:146,069,440...146,161,184
Ensembl chr 3:146,035,139...146,163,725

G

paraoxonase 1

decreases expression

2,3-pentanedione results in decreased expression of PON1 mRNA

NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532

G

peroxisome proliferator activated receptor alpha

decreases expression

2,3-pentanedione results in decreased expression of PPARA mRNA

NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755

G

prominin 1

decreases expression

2,3-pentanedione results in decreased expression of PROM1 mRNA

NCBI chr 4:15,968,228...16,084,023
Ensembl chr 4:15,963,076...16,084,378

G

serine protease 22

increases expression

2,3-pentanedione results in increased expression of PRSS22 mRNA

NCBI chr16:2,852,730...2,858,170
Ensembl chr16:2,852,730...2,858,170

G

prostaglandin-endoperoxide synthase 2

decreases expression

2,3-pentanedione results in decreased expression of PTGS2 mRNA

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

parathyroid hormone like hormone

decreases expression

2,3-pentanedione results in decreased expression of PTHLH mRNA

NCBI chr12:27,958,084...27,972,733
Ensembl chr12:27,958,084...27,972,733

G

RAS guanyl releasing protein 1

decreases expression

2,3-pentanedione results in decreased expression of RASGRP1 mRNA

NCBI chr15:38,488,103...38,564,814
Ensembl chr15:38,488,103...38,565,575

G

S100 calcium binding protein A1

decreases expression

2,3-pentanedione results in decreased expression of S100A1 mRNA

NCBI chr 1:153,628,434...153,632,039
Ensembl chr 1:153,627,926...153,632,039

G

sphingosine-1-phosphate receptor 1

decreases expression

2,3-pentanedione results in decreased expression of S1PR1 mRNA

NCBI chr 1:101,236,899...101,242,313
Ensembl chr 1:101,236,865...101,243,713

G

secretoglobin family 1A member 1

increases expression

2,3-pentanedione results in increased expression of SCGB1A1 mRNA

NCBI chr11:62,419,033...62,423,195
Ensembl chr11:62,405,103...62,423,195

G

SEC14 like lipid binding 3

decreases expression

2,3-pentanedione results in decreased expression of SEC14L3 mRNA

NCBI chr22:30,447,661...30,472,017
Ensembl chr22:30,447,959...30,472,017

G

serpin family B member 5

decreases expression

2,3-pentanedione results in decreased expression of SERPINB5 mRNA

NCBI chr18:63,476,958...63,505,085
Ensembl chr18:63,476,958...63,505,085

G

serpin family E member 1

increases expression

2,3-pentanedione results in increased expression of SERPINE1 mRNA

NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247

G

serpin family F member 1

increases expression

2,3-pentanedione results in increased expression of SERPINF1 mRNA

NCBI chr17:1,762,060...1,777,565
Ensembl chr17:1,762,029...1,777,565

G

serpin family G member 1

increases expression

2,3-pentanedione results in increased expression of SERPING1 mRNA

NCBI chr11:57,597,685...57,614,848
Ensembl chr11:57,597,387...57,619,171

G

serpin family H member 1

increases expression

2,3-pentanedione results in increased expression of SERPINH1 mRNA

NCBI chr11:75,562,253...75,572,783
Ensembl chr11:75,562,056...75,572,783

G

solute carrier family 15 member 1

increases expression

2,3-pentanedione results in increased expression of SLC15A1 mRNA

NCBI chr13:98,683,801...98,752,672
Ensembl chr13:98,683,801...98,752,672

G

solute carrier family 15 member 2

decreases expression

2,3-pentanedione results in decreased expression of SLC15A2 mRNA

NCBI chr 3:121,894,401...121,944,188
Ensembl chr 3:121,894,401...121,944,188

G

solute carrier family 23 member 1

decreases expression

2,3-pentanedione results in decreased expression of SLC23A1 mRNA

NCBI chr 5:139,367,196...139,385,676
Ensembl chr 5:139,367,196...139,384,553

G

sortilin related VPS10 domain containing receptor 2

decreases expression

2,3-pentanedione results in decreased expression of SORCS2 mRNA

NCBI chr 4:7,192,538...7,742,827
Ensembl chr 4:7,192,538...7,742,827

G

sortilin related receptor 1

decreases expression

2,3-pentanedione results in decreased expression of SORL1 mRNA

NCBI chr11:121,452,314...121,633,763
Ensembl chr11:121,452,314...121,633,763

G

sperm associated antigen 17

decreases expression

2,3-pentanedione results in decreased expression of SPAG17 mRNA

NCBI chr 1:117,953,590...118,185,228
Ensembl chr 1:117,953,590...118,185,228

G

spondin 1

increases expression

2,3-pentanedione results in increased expression of SPON1 mRNA

NCBI chr11:13,962,723...14,268,133
Ensembl chr11:13,962,723...14,268,133

G

secreted phosphoprotein 1

increases expression

2,3-pentanedione results in increased expression of SPP1 mRNA

NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532

G

sepiapterin reductase

decreases expression

2,3-pentanedione results in decreased expression of SPR mRNA

NCBI chr 2:72,887,408...72,892,158
Ensembl chr 2:72,887,382...72,892,158

G

signaling receptor and transporter of retinol STRA6

decreases expression

2,3-pentanedione results in decreased expression of STRA6 mRNA

NCBI chr15:74,179,466...74,212,259
Ensembl chr15:74,179,466...74,212,267

G

tektin 1

decreases expression

2,3-pentanedione results in decreased expression of TEKT1 mRNA

NCBI chr17:6,797,993...6,831,729
Ensembl chr17:6,789,133...6,831,761

G

transforming growth factor beta 2

increases expression

2,3-pentanedione results in increased expression of TGFB2 mRNA

NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619

G

transforming growth factor beta induced

increases expression

2,3-pentanedione results in increased expression of TGFBI mRNA

NCBI chr 5:136,028,988...136,063,818
Ensembl chr 5:136,028,988...136,063,818

G

transglutaminase 1

increases expression

2,3-pentanedione results in increased expression of TGM1 mRNA

NCBI chr14:24,249,114...24,263,177
Ensembl chr14:24,249,114...24,264,432

G

thrombospondin 2

increases expression

2,3-pentanedione results in increased expression of THBS2 mRNA

NCBI chr 6:169,215,785...169,253,846
Ensembl chr 6:169,215,780...169,254,050

G

thrombospondin 4

decreases expression

2,3-pentanedione results in decreased expression of THBS4 mRNA

NCBI chr 5:79,991,332...80,083,287
Ensembl chr 5:79,991,311...80,083,287

G

TIMP metallopeptidase inhibitor 1

increases expression

2,3-pentanedione results in increased expression of TIMP1 mRNA

NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789

G

TIMP metallopeptidase inhibitor 2

increases expression

2,3-pentanedione results in increased expression of TIMP2 mRNA

NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387

G

TIMP metallopeptidase inhibitor 4

decreases expression

2,3-pentanedione results in decreased expression of TIMP4 mRNA

NCBI chr 3:12,153,068...12,158,912
Ensembl chr 3:12,153,068...12,158,912

G

toll like receptor 2

decreases expression

2,3-pentanedione results in decreased expression of TLR2 mRNA

NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,070...153,706,260

G

transmembrane protein 178A

increases expression

2,3-pentanedione results in increased expression of TMEM178 mRNA

NCBI chr 2:39,665,483...39,735,960
Ensembl chr 2:39,664,982...39,717,963

G

tenascin C

increases expression

2,3-pentanedione results in increased expression of TNC mRNA

NCBI chr 9:115,019,575...115,118,157
Ensembl chr 9:115,019,575...115,118,207

G

TNF alpha induced protein 6

increases expression

2,3-pentanedione results in increased expression of TNFAIP6 mRNA

NCBI chr 2:151,357,592...151,381,340
Ensembl chr 2:151,357,592...151,380,046

G

TNF receptor superfamily member 12A

increases expression

2,3-pentanedione results in increased expression of TNFRSF12A mRNA

NCBI chr16:3,020,368...3,022,383
Ensembl chr16:3,018,445...3,022,383

G

tenascin N

increases expression

2,3-pentanedione results in increased expression of TNN mRNA

NCBI chr 1:175,067,833...175,148,075
Ensembl chr 1:175,067,833...175,148,075

G

ubiquitin protein ligase E3 component n-recognin 2

increases expression

2,3-pentanedione results in increased expression of UBR2 mRNA

NCBI chr 6:42,564,029...42,693,505
Ensembl chr 6:42,564,029...42,693,505

G

zinc finger protein 318

increases expression

2,3-pentanedione results in increased expression of ZFP318 mRNA

NCBI chr 6:43,336,070...43,369,647
Ensembl chr 6:43,307,134...43,369,647

G

zinc finger protein 853

decreases expression

2,3-pentanedione results in decreased expression of ZFP853 mRNA

NCBI chr 7:6,615,610...6,624,290
Ensembl chr 7:6,615,610...6,624,290

phenindione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[Phenindione results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I; [Phenindione results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I metabolite

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

tumor protein p53

increases degradation

Phenindione results in increased degradation of TP53 protein

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

vitamin K epoxide reductase complex subunit 1

multiple interactions
decreases activity

Phenindione inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
Phenindione results in decreased activity of VKORC1 protein

NCBI chr16:31,090,854...31,094,797
Ensembl chr16:31,090,842...31,095,980

G

vitamin K epoxide reductase complex subunit 1 like 1

multiple interactions
decreases activity

Phenindione inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
Phenindione results in decreased activity of VKORC1L1 protein

NCBI chr 7:65,865,772...65,959,558
Ensembl chr 7:65,873,074...65,959,563

quinoline yellow

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 1

decreases expression

quinoline yellow results in decreased expression of ESR1 protein

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

sporidesmin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catenin beta 1

affects localization

sporidesmin affects the localization of CTNNB1 protein

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

G

cytochrome P450 family 1 subfamily A member 2

affects expression

sporidesmin affects the expression of CYP1A2 mRNA

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 2 subfamily C member 18

increases expression
multiple interactions

sporidesmin results in increased expression of CYP2C18 mRNA; sporidesmin results in increased expression of CYP2C18 protein
MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]

NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190

G

cytochrome P450 family 2 subfamily C member 8

multiple interactions
affects expression

MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]

NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497

G

cytochrome P450 family 2 subfamily C member 9

increases expression

sporidesmin results in increased expression of CYP2C9 mRNA

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

dickkopf WNT signaling pathway inhibitor 3

decreases expression

sporidesmin results in decreased expression of DKK3 mRNA

NCBI chr11:11,963,036...12,009,745
Ensembl chr11:11,956,207...12,009,769

G

microRNA 1246

increases expression

sporidesmin results in increased expression of MIR1246 mRNA

NCBI chr 2:176,600,980...176,601,052
Ensembl chr 2:176,600,980...176,601,052

G

microRNA 132

increases expression

sporidesmin results in increased expression of MIR132 mRNA

NCBI chr17:2,049,908...2,050,008
Ensembl chr17:2,049,908...2,050,008

G

microRNA 138-2

increases expression

sporidesmin results in increased expression of MIR138-2 mRNA alternative form

NCBI chr16:56,858,518...56,858,601
Ensembl chr16:56,858,518...56,858,601

G

microRNA 139

increases expression

sporidesmin results in increased expression of MIR139 mRNA

NCBI chr11:72,615,063...72,615,130
Ensembl chr11:72,615,063...72,615,130

G

microRNA 149

increases expression

sporidesmin results in increased expression of MIR149 mRNA

NCBI chr 2:240,456,001...240,456,089
Ensembl chr 2:240,456,001...240,456,089

G

microRNA 150

increases expression

sporidesmin results in increased expression of MIR150 mRNA

NCBI chr19:49,500,785...49,500,868
Ensembl chr19:49,500,785...49,500,868

G

microRNA 184

increases expression

sporidesmin results in increased expression of MIR184 mRNA

NCBI chr15:79,209,788...79,209,871
Ensembl chr15:79,209,788...79,209,871

G

microRNA 1972-1

increases expression

sporidesmin results in increased expression of MIR1972-1 mRNA

NCBI chr16:15,010,321...15,010,397
Ensembl chr16:15,010,321...15,010,397

G

microRNA 21

multiple interactions
increases expression

MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]; MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
sporidesmin results in increased expression of MIR21 mRNA

NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337

G

microRNA 297

increases expression

sporidesmin results in increased expression of MIR297 mRNA

NCBI chr 4:110,860,582...110,860,647
Ensembl chr 4:110,860,582...110,860,647

G

microRNA 31

multiple interactions
increases expression

MIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
sporidesmin results in increased expression of MIR31 mRNA

NCBI chr 9:21,512,115...21,512,185
Ensembl chr 9:21,512,115...21,512,185

G

microRNA 371a

increases expression

sporidesmin results in increased expression of MIR371A mRNA

NCBI chr19:53,787,675...53,787,741
Ensembl chr19:53,787,675...53,787,741

G

microRNA 372

increases expression

sporidesmin results in increased expression of MIR372 mRNA

NCBI chr19:53,787,890...53,787,956
Ensembl chr19:53,787,890...53,787,956

G

microRNA 373

increases expression

sporidesmin results in increased expression of MIR373 mRNA

NCBI chr19:53,788,705...53,788,773
Ensembl chr19:53,788,705...53,788,773

G

microRNA 375

increases expression

sporidesmin results in increased expression of MIR375 mRNA

NCBI chr 2:219,001,645...219,001,708
Ensembl chr 2:219,001,645...219,001,708

G

microRNA 376c

increases expression

sporidesmin results in increased expression of MIR376C mRNA

NCBI chr14:101,039,690...101,039,755
Ensembl chr14:101,039,690...101,039,755

G

microRNA 379

increases expression

sporidesmin results in increased expression of MIR379 mRNA

NCBI chr14:101,022,066...101,022,132
Ensembl chr14:101,022,066...101,022,132

G

microRNA 382

increases expression

sporidesmin results in increased expression of MIR382 mRNA

NCBI chr14:101,054,306...101,054,381
Ensembl chr14:101,054,306...101,054,381

G

microRNA 409

increases expression

sporidesmin results in increased expression of MIR409 mRNA

NCBI chr14:101,065,300...101,065,378
Ensembl chr14:101,065,300...101,065,378

G

microRNA 432

increases expression

sporidesmin results in increased expression of MIR432 mRNA

NCBI chr14:100,884,483...100,884,576
Ensembl chr14:100,884,483...100,884,576

G

microRNA 4484

increases expression

sporidesmin results in increased expression of MIR4484 mRNA

NCBI chr10:125,819,740...125,819,822
Ensembl chr10:125,819,740...125,819,822

G

microRNA 4485

increases expression

sporidesmin results in increased expression of MIR4485 mRNA

NCBI chr11:10,508,270...10,508,326
Ensembl chr11:10,508,270...10,508,326

G

microRNA 487b

increases expression

sporidesmin results in increased expression of MIR487B mRNA

NCBI chr14:101,046,455...101,046,538
Ensembl chr14:101,046,455...101,046,538

G

microRNA 491

increases expression

sporidesmin results in increased expression of MIR491 mRNA

NCBI chr 9:20,716,105...20,716,188
Ensembl chr 9:20,716,105...20,716,188

G

microRNA 584

increases expression

sporidesmin results in increased expression of MIR584 mRNA

NCBI chr 5:149,062,313...149,062,409
Ensembl chr 5:149,062,313...149,062,409

G

secreted frizzled related protein 1

multiple interactions
decreases expression

MIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA]

NCBI chr 8:41,261,962...41,309,473
Ensembl chr 8:41,261,962...41,309,473

G

WNT inhibitory factor 1

affects expression
multiple interactions

sporidesmin affects the expression of WIF1 mRNA
MIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA]

NCBI chr12:65,050,626...65,121,305
Ensembl chr12:65,050,626...65,121,305

tetrahydrocurcumin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosylhomocysteinase

affects expression

Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice

RGD

NCBI chr20:34,231,981...34,311,836
Ensembl chr20:34,280,268...34,311,802

G

amyloid beta precursor protein

multiple interactions

tetrahydrocurcumin inhibits the reaction [APP protein binds to APP protein]

NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128

G

catalase

multiple interactions
affects expression

tetrahydrocurcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [Vincristine results in decreased expression of CAT protein]
Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice
tetrahydrocurcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]

CTD
RGD

PMID:17076682 PMID:25869292 PMID:26102012 PMID:30423402 PMID:22212488

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

cytochrome P450 family 1 subfamily A member 2

multiple interactions

tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA]

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 1 subfamily B member 1

multiple interactions

tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein]

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 2 subfamily B member 6

decreases expression

tetrahydrocurcumin results in decreased expression of CYP2B10 mRNA

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

G

cytochrome P450 family 2 subfamily C member 8

multiple interactions

tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein]

NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497

G

cytochrome P450 family 2 subfamily E member 1

multiple interactions

tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]

NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220

G

glutamic--pyruvic transaminase

multiple interactions

tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of GPT protein]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]

NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001

G

lecithin-cholesterol acyltransferase

multiple interactions

[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]

NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131

G

lipoprotein lipase

multiple interactions

[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]

NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259

G

matrix metallopeptidase 2

multiple interactions

tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of MMP2 protein]

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 9

multiple interactions
affects expression

tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of MMP9 protein]
Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice

CTD
RGD

PMID:25502771 PMID:22212488

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

methylenetetrahydrofolate reductase

affects expression

Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice

RGD

NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455

G

neutrophil cytosolic factor 1

affects expression

Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice

RGD

NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315

G

nitric oxide synthase 2

multiple interactions

tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein]

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

nitric oxide synthase 3

multiple interactions

tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in decreased expression of NOS3 protein]

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

tetrahydrocurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
tetrahydrocurcumin results in decreased expression of PTGS2 mRNA

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

tumor necrosis factor

multiple interactions

tetrahydrocurcumin inhibits the reaction [Vincristine results in increased expression of TNF protein]

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26034
chemical entity	26024
group	25876
inorganic group	24571
oxo group	23563
organic oxo compound	23563
carbonyl compound	23563
ketone	19347
diketone	1282
(+)-phytocassane A	0
(+)-phytocassane D	0
(+)-phytocassane E	0
(7Z)-14-hydroxy-10,13-dioxoheptadec-7-enoic acid +	0
2,2'-spirobi[3,6,7,8-tetrahydro-1H-cyclopenta[g]naphthalene]-5,5'-dione	0
2,3-epoxymenatetrenone	0
2,4-diacetylphloroglucinol	0
2,5-hexanedione	188
3,5-diacetyl-1,4-diphenyl-1,4-dihydropyridine	0
3-[(3aS,4S,7aS)-1,5-dioxo-octahydroinden-4-yl]propanoic acid	0
3-hydroxyhexane-2,5-dione	0
4,10-dihydroxyperylene-3,9-dione	0
5beta-dihydrocortisol	0
9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid +	0
acetylacetonate	1
alpha-diketone +	217
bassiatin	0
benthophoenin	0
beta-diketone +	966
bornane-2,6-dione	0
dihydrostemphyloxin I	0
ferroheme d1	0
ganoderone A	0
ganoderone C	0
humulone	0
komodoquinone A	0
komodoquinone B +	0
metribuzin-diketo	0
oligomycin A	13
oligomycin C	0
prostaglandin E2-UM	0
semi-beta-carotenone	0
sporidesmin A	33
steroid 1,3-dione +	0
terreic acid	0
Path 2
Term	Annotations
CHEBI ontology	26034
subatomic particle	26009
composite particle	26009
hadron	26020
baryon	26009
nucleon	26009
atomic nucleus	26009
atom	26009
main group element atom	25834
p-block element atom	25834
carbon group element atom	25434
carbon atom	25403
organic molecular entity	25392
heteroorganic entity	24766
organochalcogen compound	24378
organooxygen compound	24054
carbonyl compound	23563
ketone	19347
diketone	1282
(+)-phytocassane A	0
(+)-phytocassane D	0
(+)-phytocassane E	0
(7Z)-14-hydroxy-10,13-dioxoheptadec-7-enoic acid +	0
2,2'-spirobi[3,6,7,8-tetrahydro-1H-cyclopenta[g]naphthalene]-5,5'-dione	0
2,3-epoxymenatetrenone	0
2,4-diacetylphloroglucinol	0
2,5-hexanedione	188
3,5-diacetyl-1,4-diphenyl-1,4-dihydropyridine	0
3-[(3aS,4S,7aS)-1,5-dioxo-octahydroinden-4-yl]propanoic acid	0
3-hydroxyhexane-2,5-dione	0
4,10-dihydroxyperylene-3,9-dione	0
5beta-dihydrocortisol	0
9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid +	0
acetylacetonate	1
alpha-diketone +	217
bassiatin	0
benthophoenin	0
beta-diketone +	966
bornane-2,6-dione	0
dihydrostemphyloxin I	0
ferroheme d1	0
ganoderone A	0
ganoderone C	0
humulone	0
komodoquinone A	0
komodoquinone B +	0
metribuzin-diketo	0
oligomycin A	13
oligomycin C	0
prostaglandin E2-UM	0
semi-beta-carotenone	0
sporidesmin A	33
steroid 1,3-dione +	0
terreic acid	0

paths to the root