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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diketone
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Accession:CHEBI:46640 term browser browse the term
Definition:A compound that contains two ketone functionalities.
Synonyms:exact_synonym: diketones
 xref: Wikipedia:Diketone



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1-phenyl-1,2-propanedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of 1-phenyl-1,2-propanedione CTD PMID:18845131 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO 1-phenyl-1,2-propanedione results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 1-phenyl-1,2-propanedione results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of 1-phenyl-1,2-propanedione CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
JBrowse link
G Dhrs2 dehydrogenase/reductase 2 multiple interactions ISO [NADP co-treated with DHRS2 protein] affects the metabolism of 1-phenyl-1,2-propanedione CTD PMID:16685466 NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 1-phenyl-1,2-propanedione results in increased expression of HMOX1 mRNA CTD PMID:20491607 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO 1-phenyl-1,2-propanedione results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
JBrowse link
2,5-hexanedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 increases expression EXP 2,5-hexanedione results in increased expression of ABI2 mRNA CTD PMID:22952946 PMID:27466211 NCBI chr 9:61,856,379...61,904,029
Ensembl chr 9:61,827,139...61,905,699
JBrowse link
G Aco2 aconitase 2 increases expression EXP 2,5-hexanedione results in increased expression of ACO2 protein CTD PMID:19033394 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression
multiple interactions
EXP 2,5-hexanedione results in increased expression of AIF1 protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of AIF1 protein]
CTD PMID:32522579 PMID:32860822 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
increases expression
ISO 2,5-hexanedione results in decreased phosphorylation of AKT1 protein
2,5-hexanedione results in increased expression of AKT1 mRNA
CTD PMID:33197454 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B decreases expression EXP 2,5-hexanedione results in decreased expression of ALOX15B mRNA CTD PMID:22952946 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812
JBrowse link
G Angptl4 angiopoietin-like 4 affects expression EXP 2,5-hexanedione affects the expression of ANGPTL4 mRNA CTD PMID:20616210 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Arg1 arginase 1 decreases expression
multiple interactions
EXP 2,5-hexanedione results in decreased expression of ARG1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of ARG1 mRNA]
CTD PMID:32522579 PMID:32860822 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO
EXP
2,5-hexanedione results in increased expression of BAX mRNA; 2,5-hexanedione results in increased expression of BAX protein CTD PMID:17492505 PMID:21901545 PMID:22337490 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
EXP
ISO
2,5-hexanedione results in increased expression of BCL2 protein
2,5-hexanedione results in decreased expression of BCL2 mRNA
2,5-hexanedione results in decreased expression of BCL2 mRNA; 2,5-hexanedione results in decreased expression of BCL2 protein
CTD PMID:17492505 PMID:21901545 PMID:22337490 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l14 BCL2 like 14 increases expression EXP 2,5-hexanedione results in increased expression of BCL2L14 mRNA CTD PMID:22952946 NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression EXP 2,5-hexanedione results in decreased expression of BDNF protein CTD PMID:31760062 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bfar bifunctional apoptosis regulator increases expression EXP 2,5-hexanedione results in increased expression of BFAR mRNA CTD PMID:22952946 NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038
JBrowse link
G Casp1 caspase 1 increases cleavage
increases expression
multiple interactions
EXP 2,5-hexanedione results in increased cleavage of CASP1 protein
2,5-hexanedione results in increased expression of CASP1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of CASP1 protein]
CTD PMID:32522579 PMID:32860822 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 increases expression ISO
EXP
2,5-hexanedione results in increased expression of CASP3 mRNA; 2,5-hexanedione results in increased expression of CASP3 protein alternative form CTD PMID:17492505 PMID:21901545 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 decreases expression ISO 2,5-hexanedione results in decreased expression of CASP8 protein CTD PMID:33197454 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccdc171 coiled-coil domain containing 171 increases expression EXP 2,5-hexanedione results in increased expression of CCDC171 mRNA CTD PMID:22952946 NCBI chr 5:97,919,965...98,403,853 JBrowse link
G Ccdc191 coiled-coil domain containing 191 increases expression EXP 2,5-hexanedione results in increased expression of CCDC191 mRNA CTD PMID:22952946 NCBI chr11:56,735,655...56,806,372
Ensembl chr11:56,735,652...56,806,375
JBrowse link
G Cdin1 CDAN1 interacting nuclease 1 increases expression EXP 2,5-hexanedione results in increased expression of CDIN1 mRNA CTD PMID:22952946 NCBI chr 3:102,441,553...102,646,935
Ensembl chr 3:102,441,704...102,646,682
JBrowse link
G Cep112 centrosomal protein 112 increases expression EXP 2,5-hexanedione results in increased expression of CEP112 mRNA CTD PMID:22952946 NCBI chr10:93,366,059...93,833,133
Ensembl chr10:93,366,136...93,833,131
JBrowse link
G Cfap221 cilia and flagella associated protein 221 increases expression EXP 2,5-hexanedione results in increased expression of CFAP221 mRNA CTD PMID:22952946 NCBI chr13:31,046,550...31,118,141
Ensembl chr13:31,046,535...31,116,899
JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 increases expression EXP 2,5-hexanedione results in increased expression of CKMT1B protein CTD PMID:19033394 NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758
JBrowse link
G Clca2 chloride channel accessory 2 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of CLCA2 mRNA CTD PMID:22382377 NCBI chr 2:233,993,619...234,022,691
Ensembl chr 2:233,995,078...234,022,199
JBrowse link
G Clu clusterin decreases expression
increases expression
EXP 2,5-hexanedione results in decreased expression of CLU mRNA
2,5-hexanedione results in increased expression of CLU mRNA
CTD PMID:22952946 PMID:27466211 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Ctxn1 cortexin 1 increases expression EXP 2,5-hexanedione results in increased expression of CTXN1 mRNA CTD PMID:22952946 NCBI chr12:2,610,465...2,612,076 JBrowse link
G Dcn decorin increases expression EXP 2,5-hexanedione results in increased expression of DCN mRNA CTD PMID:22952946 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Dennd1a DENN domain containing 1A increases expression EXP 2,5-hexanedione results in increased expression of DENND1A mRNA CTD PMID:22952946 NCBI chr 3:21,564,749...22,052,057
Ensembl chr 3:21,564,749...22,052,062
JBrowse link
G Dicer1 dicer 1 ribonuclease III increases expression ISO 2,5-hexanedione results in increased expression of DICER1 mRNA CTD PMID:33197454 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
JBrowse link
G Dnaaf11 dynein axonemal assembly factor 11 increases expression EXP 2,5-hexanedione results in increased expression of DNAAF11 mRNA CTD PMID:22952946 NCBI chr 7:98,141,525...98,245,906
Ensembl chr 7:98,144,763...98,245,837
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression EXP 2,5-hexanedione results in increased expression of DNAJB4 mRNA CTD PMID:22952946 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
JBrowse link
G Dpp7 dipeptidylpeptidase 7 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of DPP7 mRNA CTD PMID:22382377 NCBI chr 3:8,165,091...8,169,343
Ensembl chr 3:8,165,091...8,169,355
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 decreases expression EXP 2,5-hexanedione results in decreased expression of DPYSL2 protein CTD PMID:19033394 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
JBrowse link
G Egfr epidermal growth factor receptor increases expression EXP 2,5-hexanedione results in increased expression of EGFR mRNA CTD PMID:16141653 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 increases expression EXP 2,5-hexanedione results in increased expression of ERC1 mRNA CTD PMID:22952946 NCBI chr 4:152,763,664...153,055,706
Ensembl chr 4:152,767,419...153,055,639
JBrowse link
G Faslg Fas ligand increases expression EXP 2,5-hexanedione results in increased expression of FASLG mRNA CTD PMID:22337490 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase decreases expression EXP 2,5-hexanedione results in decreased expression of FASN protein CTD PMID:19033394 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fcer1g Fc epsilon receptor Ig increases expression EXP 2,5-hexanedione results in increased expression of FCER1G mRNA CTD PMID:22952946 NCBI chr13:83,649,447...83,654,215
Ensembl chr13:83,649,449...83,671,443
JBrowse link
G Foxo3 forkhead box O3 increases phosphorylation
decreases expression
ISO 2,5-hexanedione results in increased phosphorylation of FOXO3 protein
2,5-hexanedione results in decreased expression of FOXO3 mRNA
CTD PMID:33197454 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP 2,5-hexanedione results in increased expression of GADD45 mRNA CTD PMID:16141653 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gas2 growth arrest-specific 2 increases expression EXP 2,5-hexanedione results in increased expression of GAS2 mRNA CTD PMID:22952946 NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression
EXP 2,5-hexanedione results in decreased expression of GFAP protein
2,5-hexanedione results in increased expression of GFAP protein
CTD PMID:19033394 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ghsr growth hormone secretagogue receptor affects expression EXP 2,5-hexanedione affects the expression of GHSR mRNA CTD PMID:20616210 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
JBrowse link
G Glud1 glutamate dehydrogenase 1 increases expression EXP 2,5-hexanedione results in increased expression of GLUD1 protein CTD PMID:19033394 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
JBrowse link
G Gsdmd gasdermin D multiple interactions
increases cleavage
EXP Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of GSDMD protein] CTD PMID:32522579 PMID:32860822 NCBI chr 7:107,542,242...107,547,052
Ensembl chr 7:107,542,083...107,547,055
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression EXP 2,5-hexanedione results in decreased expression of GSK3B protein CTD PMID:31760062 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsn gelsolin decreases expression EXP 2,5-hexanedione results in decreased expression of GSN protein CTD PMID:19033394 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Gstm3 glutathione S-transferase mu 3 decreases expression EXP 2,5-hexanedione results in decreased expression of GSTM5 protein CTD PMID:19033394 NCBI chr 2:195,590,450...195,612,578
Ensembl chr 2:195,607,289...195,612,475
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression EXP 2,5-hexanedione results in decreased expression of GSTP1 mRNA CTD PMID:16141653 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hdgfl1 HDGF like 1 decreases expression EXP 2,5-hexanedione results in decreased expression of HDGFL1 mRNA CTD PMID:22952946 NCBI chr17:38,207,906...38,209,902 JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression EXP 2,5-hexanedione results in increased expression of HSPA1B mRNA CTD PMID:16141653 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Ier3 immediate early response 3 affects expression EXP 2,5-hexanedione affects the expression of IER3 mRNA CTD PMID:20616210 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Ift81 intraflagellar transport 81 increases expression EXP 2,5-hexanedione results in increased expression of IFT81 mRNA CTD PMID:22952946 NCBI chr12:33,957,744...34,037,164
Ensembl chr12:33,957,806...34,037,057
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases expression EXP 2,5-hexanedione results in decreased expression of IGFBP3 mRNA CTD PMID:16141653 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP 2,5-hexanedione results in increased expression of IL1B mRNA; 2,5-hexanedione results in increased expression of IL1B protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of IL1B protein]
CTD PMID:16141653 PMID:32522579 PMID:32860822 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha decreases expression EXP 2,5-hexanedione results in decreased expression of INA protein CTD PMID:19033394 NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330
JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions
ISO
EXP
2,5-hexanedione results in increased expression of ITGAM protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of ITGAM protein]
CTD PMID:19464574 PMID:32522579 PMID:32860822 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression EXP 2,5-hexanedione results in decreased expression of ITGB1 mRNA CTD PMID:16141653 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Kif6 kinesin family member 6 increases expression EXP 2,5-hexanedione results in increased expression of KIF6 mRNA CTD PMID:22952946 NCBI chr 9:11,076,203...11,373,205
Ensembl chr 9:11,072,824...11,373,006
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression
multiple interactions
EXP 2,5-hexanedione results in decreased expression of KIT protein
resveratrol inhibits the reaction [2,5-hexanedione results in decreased expression of KIT protein]
CTD PMID:17725299 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Loxl1 lysyl oxidase-like 1 increases expression
multiple interactions
EXP 2,5-hexanedione results in increased expression of LOXL1 protein
2,5-hexanedione promotes the reaction [carbendazim results in increased expression of LOXL1 protein]; [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of LOXL1 mRNA
CTD PMID:22382377 NCBI chr 8:58,692,592...58,716,356
Ensembl chr 8:58,692,593...58,716,356
JBrowse link
G Lrrc69 leucine rich repeat containing 69 increases expression EXP 2,5-hexanedione results in increased expression of LRRC69 mRNA CTD PMID:22952946 NCBI chr 5:28,023,591...28,181,963
Ensembl chr 5:28,023,593...28,214,384
JBrowse link
G Lyz2 lysozyme 2 decreases expression
increases expression
EXP 2,5-hexanedione results in decreased expression of LYZ2 mRNA
2,5-hexanedione results in increased expression of LYZ2 mRNA
CTD PMID:22952946 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Macrod1 mono-ADP ribosylhydrolase 1 increases expression
multiple interactions
EXP 2,5-hexanedione results in increased expression of MACROD1 mRNA
[carbendazim co-treated with 2,5-hexanedione] results in decreased expression of MACROD1 mRNA
CTD PMID:22382377 NCBI chr 1:204,246,238...204,387,027
Ensembl chr 1:204,246,166...204,389,716
JBrowse link
G Map1a microtubule-associated protein 1A decreases expression EXP 2,5-hexanedione results in decreased expression of MAP1A protein CTD PMID:20554699 NCBI chr 3:108,263,217...108,283,936
Ensembl chr 3:108,263,151...108,282,899
JBrowse link
G Map1b microtubule-associated protein 1B decreases expression EXP 2,5-hexanedione results in decreased expression of MAP1B protein; 2,5-hexanedione results in decreased expression of MAP1B protein modified form CTD PMID:20554699 PMID:31760062 NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
JBrowse link
G Map2 microtubule-associated protein 2 decreases expression EXP 2,5-hexanedione results in decreased expression of MAP2 protein modified form CTD PMID:20554699 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression EXP 2,5-hexanedione results in increased expression of MAP3K1 protein CTD PMID:31760062 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Mapt microtubule-associated protein tau decreases expression EXP 2,5-hexanedione results in decreased expression of MAPT protein modified form CTD PMID:20554699 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mbp myelin basic protein multiple interactions
decreases expression
EXP Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MBP protein] CTD PMID:32522579 PMID:32860822 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression EXP 2,5-hexanedione results in increased expression of MDH1 protein CTD PMID:19033394 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Mfap3l microfibril associated protein 3 like increases expression EXP 2,5-hexanedione results in increased expression of MFAP3L mRNA CTD PMID:22952946 NCBI chr16:29,411,643...29,454,665
Ensembl chr16:29,415,849...29,430,863
JBrowse link
G Mir10b microRNA 10b increases expression EXP 2,5-hexanedione results in increased expression of MIR10B mRNA CTD PMID:31760062 NCBI chr 3:59,628,438...59,628,546
Ensembl chr 3:59,628,438...59,628,546
JBrowse link
G Mir1224 microRNA 1224 increases expression EXP 2,5-hexanedione results in increased expression of MIR1224 mRNA CTD PMID:31760062 NCBI chr11:80,306,902...80,306,986
Ensembl chr11:80,306,902...80,306,986
JBrowse link
G Mir125a microRNA 125a increases expression
decreases expression
EXP 2,5-hexanedione results in increased expression of MIR125A mRNA
2,5-hexanedione results in decreased expression of MIR125A mRNA
CTD PMID:31760062 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710
JBrowse link
G Mir130b microRNA 130b decreases expression EXP 2,5-hexanedione results in decreased expression of MIR130B mRNA CTD PMID:31760062 NCBI chr11:83,880,163...83,880,244
Ensembl chr11:83,880,163...83,880,244
JBrowse link
G Mir134 microRNA 134 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR134 mRNA CTD PMID:31760062 NCBI chr 6:128,748,908...128,748,980 JBrowse link
G Mir155 microRNA 155 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR155 mRNA CTD PMID:31760062 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir183 microRNA 183 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR183 mRNA CTD PMID:31760062 NCBI chr 4:58,788,614...58,788,723
Ensembl chr 4:58,788,614...58,788,723
JBrowse link
G Mir193 microRNA 193 increases expression EXP 2,5-hexanedione results in increased expression of MIR193 mRNA CTD PMID:31760062 NCBI chr10:64,672,354...64,672,439 JBrowse link
G Mir193a microRNA 193a decreases expression EXP 2,5-hexanedione results in decreased expression of MIR193A mRNA CTD PMID:31760062 NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454
JBrowse link
G Mir194-2 microRNA 194-2 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR194-2 mRNA CTD PMID:31760062 NCBI chr 1:203,564,761...203,564,845
Ensembl chr 1:203,564,761...203,564,845
JBrowse link
G Mir196a microRNA 196a increases expression EXP 2,5-hexanedione results in increased expression of MIR196A mRNA CTD PMID:31760062 NCBI chr 7:134,110,400...134,110,509
Ensembl chr 7:134,110,400...134,110,509
JBrowse link
G Mir196c microRNA 196c increases expression EXP 2,5-hexanedione results in increased expression of MIR196C mRNA CTD PMID:31760062 NCBI chr10:81,231,006...81,231,085
Ensembl chr10:81,231,006...81,231,085
JBrowse link
G Mir199a2 microRNA 199a-2 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR199A-2 mRNA; 2,5-hexanedione results in decreased expression of MIR199A2 mRNA CTD PMID:31760062 NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063
JBrowse link
G Mir200c microRNA 200c decreases expression EXP 2,5-hexanedione results in decreased expression of MIR200C mRNA CTD PMID:31760062 NCBI chr 4:157,523,679...157,523,747 JBrowse link
G Mir202 microRNA 202 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR202 mRNA CTD PMID:31760062 NCBI chr 1:194,754,730...194,754,801
Ensembl chr 1:194,754,730...194,754,801
JBrowse link
G Mir206 microRNA 206 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR206 mRNA CTD PMID:31760062 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
JBrowse link
G Mir208a microRNA 208a increases expression EXP 2,5-hexanedione results in increased expression of MIR208A mRNA CTD PMID:31760062 NCBI chr15:28,425,570...28,425,652 JBrowse link
G Mir20a microRNA 20a decreases expression EXP 2,5-hexanedione results in decreased expression of MIR20A mRNA CTD PMID:31760062 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168
JBrowse link
G Mir21 microRNA 21 increases expression
decreases expression
EXP 2,5-hexanedione results in increased expression of MIR21 mRNA
2,5-hexanedione results in decreased expression of MIR21 mRNA
CTD PMID:31760062 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir212 microRNA 212 increases expression EXP 2,5-hexanedione results in increased expression of MIR212 mRNA CTD PMID:31760062 NCBI chr10:60,023,403...60,023,513
Ensembl chr10:60,023,403...60,023,513
JBrowse link
G Mir22 microRNA 22 increases expression EXP 2,5-hexanedione results in increased expression of MIR22 mRNA CTD PMID:31760062 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
JBrowse link
G Mir223 microRNA 223 increases expression EXP 2,5-hexanedione results in increased expression of MIR223 mRNA CTD PMID:31760062 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996
JBrowse link
G Mir224 microRNA 224 increases expression EXP 2,5-hexanedione results in increased expression of MIR224 mRNA CTD PMID:31760062 NCBI chr  X:150,065,088...150,065,169
Ensembl chr  X:150,065,088...150,065,169
JBrowse link
G Mir27a microRNA 27a decreases expression EXP 2,5-hexanedione results in decreased expression of MIR27A mRNA CTD PMID:31760062 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917
JBrowse link
G Mir27b microRNA 27b increases expression EXP 2,5-hexanedione results in increased expression of MIR27B mRNA CTD PMID:31760062 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529
JBrowse link
G Mir300 microRNA 300 increases expression EXP 2,5-hexanedione results in increased expression of MIR300 mRNA CTD PMID:31760062 NCBI chr 6:128,738,513...128,738,591
Ensembl chr 6:128,738,505...128,738,594
JBrowse link
G Mir30a microRNA 30a increases expression EXP 2,5-hexanedione results in increased expression of MIR30A mRNA CTD PMID:31760062 NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670
JBrowse link
G Mir32 microRNA 32 increases expression EXP 2,5-hexanedione results in increased expression of MIR32 mRNA CTD PMID:31760062 NCBI chr 5:71,596,083...71,596,152
Ensembl chr 5:71,596,083...71,596,152
JBrowse link
G Mir320a microRNA 320a increases expression EXP 2,5-hexanedione results in increased expression of MIR320A mRNA CTD PMID:31760062 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473
JBrowse link
G Mir323 microRNA 323 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR323 mRNA CTD PMID:31760062 NCBI chr 6:128,725,539...128,725,624
Ensembl chr 6:128,725,539...128,725,624
JBrowse link
G Mir326 microRNA 326 increases expression EXP 2,5-hexanedione results in increased expression of MIR326 mRNA CTD PMID:31760062 NCBI chr 1:153,854,029...153,854,123
Ensembl chr 1:153,854,029...153,854,123
JBrowse link
G Mir33 microRNA 33 increases expression EXP 2,5-hexanedione results in increased expression of MIR33 mRNA CTD PMID:31760062 NCBI chr 7:113,713,855...113,713,923
Ensembl chr 7:113,713,855...113,713,923
JBrowse link
G Mir330 microRNA 330 increases expression EXP 2,5-hexanedione results in increased expression of MIR330 mRNA CTD PMID:31760062 NCBI chr 1:78,833,178...78,833,274
Ensembl chr 1:78,833,178...78,833,274
JBrowse link
G Mir331 microRNA 331 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR331 mRNA CTD PMID:31760062 NCBI chr 7:28,527,390...28,527,485
Ensembl chr 7:28,527,390...28,527,485
JBrowse link
G Mir339 microRNA 339 increases expression EXP 2,5-hexanedione results in increased expression of MIR339 mRNA CTD PMID:31760062 NCBI chr12:15,277,546...15,277,641
Ensembl chr12:15,277,546...15,277,641
JBrowse link
G Mir344-1 microRNA 344-1 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR344-1 mRNA CTD PMID:31760062 NCBI chr 1:115,306,861...115,306,958 JBrowse link
G Mir345 microRNA 345 increases expression EXP 2,5-hexanedione results in increased expression of MIR345 mRNA CTD PMID:31760062 NCBI chr 6:127,754,027...127,754,122
Ensembl chr 6:127,754,027...127,754,122
JBrowse link
G Mir3556a microRNA 3556a decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3556A mRNA CTD PMID:31760062 NCBI chr 4:59,650,596...59,650,713
Ensembl chr 4:59,650,596...59,650,713
JBrowse link
G Mir3558 microRNA 3558 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3558 mRNA CTD PMID:31760062 NCBI chr 6:7,181,751...7,181,864
Ensembl chr 6:7,181,751...7,181,864
JBrowse link
G Mir3560 microRNA 3560 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3560 mRNA CTD PMID:31760062 NCBI chr  X:15,255,308...15,255,419
Ensembl chr  X:15,255,308...15,255,419
JBrowse link
G Mir3573 microRNA 3573 increases expression EXP 2,5-hexanedione results in increased expression of MIR3573 mRNA CTD PMID:31760062 NCBI chr  X:64,259,096...64,259,167
Ensembl chr  X:64,259,096...64,259,167
JBrowse link
G Mir3580 microRNA 3580 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3580 mRNA CTD PMID:31760062 NCBI chr  X:145,445,018...145,445,098
Ensembl chr  X:145,445,018...145,445,098
JBrowse link
G Mir3593 microRNA 3593 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3593 mRNA CTD PMID:31760062 NCBI chr 6:73,252,647...73,252,737
Ensembl chr 6:73,252,647...73,252,737
JBrowse link
G Mir370 microRNA 370 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR370 mRNA CTD PMID:31760062 NCBI chr 6:128,572,257...128,572,335
Ensembl chr 6:128,572,257...128,572,335
JBrowse link
G Mir375 microRNA 375 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR375 mRNA CTD PMID:31760062 NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985
JBrowse link
G Mir412 microRNA 412 increases expression EXP 2,5-hexanedione results in increased expression of MIR412 mRNA CTD PMID:31760062 NCBI chr 6:128,757,932...128,758,001
Ensembl chr 6:128,757,926...128,758,005
JBrowse link
G Mir423 microRNA 423 increases expression EXP 2,5-hexanedione results in increased expression of MIR423 mRNA CTD PMID:31760062 NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226
JBrowse link
G Mir433 microRNA 433 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR433 mRNA CTD PMID:31760062 NCBI chr 6:128,545,119...128,545,211
Ensembl chr 6:128,545,112...128,545,217
JBrowse link
G Mir450a1 microRNA 450a-1 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR450A1 mRNA CTD PMID:31760062 NCBI chr  X:132,801,380...132,801,470 JBrowse link
G Mir487b microRNA 487b increases expression EXP 2,5-hexanedione results in increased expression of MIR487B mRNA CTD PMID:31760062 NCBI chr 6:128,741,485...128,741,566
Ensembl chr 6:128,741,485...128,741,566
JBrowse link
G Mir488 microRNA 488 increases expression EXP 2,5-hexanedione results in increased expression of MIR488 mRNA CTD PMID:31760062 NCBI chr13:70,683,064...70,683,142
Ensembl chr13:70,683,064...70,683,142
JBrowse link
G Mir497 microRNA 497 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR497 mRNA CTD PMID:31760062 NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584
JBrowse link
G Mir503 microRNA 503 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR503 mRNA CTD PMID:31760062 NCBI chr  X:132,806,303...132,806,373 JBrowse link
G Mir541 microRNA 541 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR541 mRNA CTD PMID:31760062 NCBI chr 6:128,757,016...128,757,105
Ensembl chr 6:128,757,016...128,757,105
JBrowse link
G Mir542 microRNA 542 increases expression EXP 2,5-hexanedione results in increased expression of MIR542 mRNA CTD PMID:31760062 NCBI chr  X:132,802,623...132,802,701 JBrowse link
G Mir551b microRNA 551b decreases expression EXP 2,5-hexanedione results in decreased expression of MIR551B mRNA CTD PMID:31760062 NCBI chr 2:113,989,203...113,989,300
Ensembl chr 2:113,989,203...113,989,300
JBrowse link
G Mir582 microRNA 582 increases expression EXP 2,5-hexanedione results in increased expression of MIR582 mRNA CTD PMID:31760062 NCBI chr 2:40,928,571...40,928,651
Ensembl chr 2:40,928,571...40,928,651
JBrowse link
G Mir652 microRNA 652 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR652 mRNA CTD PMID:31760062 NCBI chr  X:106,343,293...106,343,373
Ensembl chr  X:106,343,293...106,343,373
JBrowse link
G Mir653 microRNA 653 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR653 mRNA CTD PMID:31760062 NCBI chr 4:31,692,714...31,692,810
Ensembl chr 4:31,692,714...31,692,810
JBrowse link
G Mir665 microRNA 665 increases expression EXP 2,5-hexanedione results in increased expression of MIR665 mRNA CTD PMID:31760062 NCBI chr 6:128,539,440...128,539,533
Ensembl chr 6:128,539,440...128,539,533
JBrowse link
G Mir675 microRNA 675 increases expression EXP 2,5-hexanedione results in increased expression of MIR675 mRNA CTD PMID:31760062 NCBI chr 1:197,732,275...197,732,358
Ensembl chr 1:197,732,275...197,732,358
JBrowse link
G Mir743a microRNA 743a increases expression EXP 2,5-hexanedione results in increased expression of MIR743A mRNA CTD PMID:31760062 NCBI chr  X:145,402,692...145,402,767
Ensembl chr  X:145,402,692...145,402,767
JBrowse link
G Mir760 microRNA 760 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR760 mRNA CTD PMID:31760062 NCBI chr 2:210,392,616...210,392,695
Ensembl chr 2:210,392,616...210,392,695
JBrowse link
G Mir770 microRNA 770 increases expression EXP 2,5-hexanedione results in increased expression of MIR770 mRNA CTD PMID:31760062 NCBI chr 6:128,515,843...128,515,918
Ensembl chr 6:128,515,835...128,515,928
JBrowse link
G Mir7a2 microRNA 7a-2 increases expression EXP 2,5-hexanedione results in increased expression of MIR7A2 mRNA CTD PMID:31760062 NCBI chr 1:132,806,420...132,806,514
Ensembl chr 1:132,806,420...132,806,514
JBrowse link
G Mir873 microRNA 873 increases expression EXP 2,5-hexanedione results in increased expression of MIR873 mRNA CTD PMID:31760062 NCBI chr 5:51,356,919...51,356,995
Ensembl chr 5:51,356,919...51,356,995
JBrowse link
G Mir877 microRNA 877 increases expression EXP 2,5-hexanedione results in increased expression of MIR877 mRNA CTD PMID:31760062 NCBI chr20:2,811,476...2,811,560
Ensembl chr20:2,811,476...2,811,560
JBrowse link
G Mir883 microRNA 883 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR883 mRNA CTD PMID:31760062 NCBI chr  X:145,410,566...145,410,642
Ensembl chr  X:145,410,566...145,410,642
JBrowse link
G Mirlet7b microRNA let-7b increases expression EXP 2,5-hexanedione results in increased expression of MIRLET7B mRNA CTD PMID:31760062 NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270
JBrowse link
G Mirlet7i microRNA let-7i increases expression EXP 2,5-hexanedione results in increased expression of MIRLET7I mRNA CTD PMID:31760062 NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571
JBrowse link
G Mrc1 mannose receptor, C type 1 decreases expression
multiple interactions
EXP 2,5-hexanedione results in decreased expression of MRC1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MRC1 mRNA]
CTD PMID:32522579 PMID:32860822 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Mtm1 myotubularin 1 increases expression EXP 2,5-hexanedione results in increased expression of MTM1 mRNA CTD PMID:22952946 NCBI chr 6:488,691...506,964
Ensembl chr 6:488,969...506,860
JBrowse link
G Napa NSF attachment protein alpha decreases expression EXP 2,5-hexanedione results in decreased expression of NAPA protein CTD PMID:19033394 NCBI chr 1:76,787,036...76,805,869
Ensembl chr 1:76,786,932...76,805,869
JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 increases expression
decreases expression
EXP 2,5-hexanedione results in increased expression of NDUFA10 protein
2,5-hexanedione results in decreased expression of NDUFA10 protein
CTD PMID:19033394 NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560
JBrowse link
G Nefh neurofilament heavy chain decreases expression EXP 2,5-hexanedione results in decreased expression of NEFH protein CTD PMID:19033394 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nefl neurofilament light chain decreases expression
multiple interactions
EXP 2,5-hexanedione results in decreased expression of NEFL protein
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of NEFL protein]
CTD PMID:19033394 PMID:32522579 PMID:32860822 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Nefm neurofilament medium chain decreases expression EXP 2,5-hexanedione results in decreased expression of NEFM protein CTD PMID:19033394 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression
EXP Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NLRP3 protein]
2,5-hexanedione results in increased expression of NLRP3 mRNA; 2,5-hexanedione results in increased expression of NLRP3 protein
CTD PMID:32522579 PMID:32860822 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP 2,5-hexanedione results in increased expression of NOS2 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NOS2 mRNA]
CTD PMID:32522579 PMID:32860822 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase decreases expression EXP 2,5-hexanedione results in decreased expression of NSF protein CTD PMID:19033394 NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
JBrowse link
G Nupr2 nuclear protein 2, transcriptional regulator increases expression EXP 2,5-hexanedione results in increased expression of NUPR1L mRNA CTD PMID:22952946 NCBI chr12:26,800,123...26,803,228
Ensembl chr12:26,799,800...26,803,304
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression EXP 2,5-hexanedione results in decreased expression of PDIA3 protein CTD PMID:19033394 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pdlim3 PDZ and LIM domain 3 decreases expression EXP 2,5-hexanedione results in decreased expression of PDLIM3 protein CTD PMID:19033394 NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657
JBrowse link
G Pgam1 phosphoglycerate mutase 1 increases expression EXP 2,5-hexanedione results in increased expression of PGAM1 protein CTD PMID:19033394 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452
JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 increases expression EXP 2,5-hexanedione results in increased expression of PHOSPHO1 mRNA CTD PMID:22952946 NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases expression ISO 2,5-hexanedione results in decreased expression of PIK3CA mRNA CTD PMID:33197454 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression ISO 2,5-hexanedione results in decreased expression of PIK3R1 protein CTD PMID:33197454 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression EXP 2,5-hexanedione results in increased expression of PIM1 mRNA CTD PMID:22952946 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
JBrowse link
G Pkm pyruvate kinase M1/2 increases expression EXP 2,5-hexanedione results in increased expression of PKM protein CTD PMID:19033394 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Pou2f1 POU class 2 homeobox 1 increases expression EXP 2,5-hexanedione results in increased expression of POU2F1 mRNA CTD PMID:22952946 NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
JBrowse link
G Prkcsh protein kinase C substrate 80K-H decreases expression EXP 2,5-hexanedione results in decreased expression of PRKCSH protein CTD PMID:19033394 NCBI chr 8:20,534,787...20,546,493
Ensembl chr 8:20,534,880...20,546,492
JBrowse link
G Ptgds prostaglandin D2 synthase increases expression EXP 2,5-hexanedione results in increased expression of PTGDS mRNA CTD PMID:22952946 PMID:27466211 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
JBrowse link
G Pycard PYD and CARD domain containing increases expression EXP 2,5-hexanedione results in increased expression of PYCARD mRNA; 2,5-hexanedione results in increased expression of PYCARD protein CTD PMID:32860822 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Pygb glycogen phosphorylase B decreases expression EXP 2,5-hexanedione results in decreased expression of PYGB protein CTD PMID:19033394 NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553
JBrowse link
G Pygm glycogen phosphorylase, muscle associated decreases expression EXP 2,5-hexanedione results in decreased expression of PYGM protein CTD PMID:19033394 NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368
JBrowse link
G Ralgapa2 Ral GTPase activating protein catalytic subunit alpha 2 increases expression EXP 2,5-hexanedione results in increased expression of RALGAPA2 mRNA CTD PMID:22952946 NCBI chr 3:133,661,955...133,938,821
Ensembl chr 3:133,659,761...133,938,916
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 2,5-hexanedione results in decreased expression of and affects the localization of RELA protein CTD PMID:22337490 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G RGD1304694 similar to CG9646-PA increases expression EXP 2,5-hexanedione results in increased expression of RGD1304694 mRNA CTD PMID:22952946 NCBI chr 7:116,068,047...116,107,713
Ensembl chr 7:116,071,447...116,107,727
JBrowse link
G RGD1562608 similar to KIAA1328 protein increases expression EXP 2,5-hexanedione results in increased expression of RGD1562608 mRNA CTD PMID:22952946 NCBI chr18:16,488,569...16,776,373
Ensembl chr18:16,489,408...16,775,548
JBrowse link
G Rtkn2 rhotekin 2 increases expression EXP 2,5-hexanedione results in increased expression of RTKN2 mRNA CTD PMID:22952946 NCBI chr20:20,525,256...20,609,951
Ensembl chr20:20,525,256...20,609,951
JBrowse link
G S100z S100 calcium binding protein Z increases expression EXP 2,5-hexanedione results in increased expression of S100Z mRNA CTD PMID:22952946 NCBI chr 2:26,738,780...26,753,611
Ensembl chr 2:26,738,776...26,752,390
JBrowse link
G Sclt1 sodium channel and clathrin linker 1 increases expression EXP 2,5-hexanedione results in increased expression of SCLT1 mRNA CTD PMID:22952946 NCBI chr 2:124,605,445...124,763,964
Ensembl chr 2:124,605,658...124,764,065
JBrowse link
G Septin8 septin 8 decreases expression EXP 2,5-hexanedione results in decreased expression of SEPTIN8 protein CTD PMID:19033394 NCBI chr10:37,684,639...37,713,704
Ensembl chr10:37,684,639...37,713,174
JBrowse link
G Sh2d4a SH2 domain containing 4A decreases expression EXP 2,5-hexanedione results in decreased expression of SH2D4A mRNA CTD PMID:22952946 NCBI chr16:21,339,010...21,409,360
Ensembl chr16:21,340,015...21,409,260
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] affects the expression of SHANK3 mRNA CTD PMID:22382377 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374
JBrowse link
G Sil1 SIL1 nucleotide exchange factor increases expression EXP 2,5-hexanedione results in increased expression of SIL1 mRNA CTD PMID:22952946 NCBI chr18:26,872,423...27,104,365
Ensembl chr18:26,872,429...27,104,332
JBrowse link
G Slc10a7 solute carrier family 10, member 7 increases expression EXP 2,5-hexanedione results in increased expression of SLC10A7 mRNA CTD PMID:22952946 NCBI chr19:29,183,143...29,407,470
Ensembl chr19:29,183,155...29,407,464
JBrowse link
G Sltm SAFB-like, transcription modulator increases expression EXP 2,5-hexanedione results in increased expression of SLTM mRNA CTD PMID:22952946 NCBI chr 8:71,215,995...71,261,821
Ensembl chr 8:71,216,612...71,261,825
JBrowse link
G Sod3 superoxide dismutase 3 increases expression EXP 2,5-hexanedione results in increased expression of SOD3 mRNA CTD PMID:22952946 PMID:27466211 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Sppl3 signal peptide peptidase like 3 increases expression EXP 2,5-hexanedione results in increased expression of SPPL3 mRNA CTD PMID:22952946 NCBI chr12:41,515,635...41,600,079
Ensembl chr12:41,515,640...41,600,126
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 decreases expression EXP 2,5-hexanedione results in decreased expression of SPTAN1 protein CTD PMID:19033394 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
JBrowse link
G Stmn1 stathmin 1 decreases expression EXP 2,5-hexanedione results in decreased expression of STMN1 mRNA CTD PMID:22952946 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Strbp spermatid perinuclear RNA binding protein increases expression EXP 2,5-hexanedione results in increased expression of STRBP mRNA CTD PMID:22952946 NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949
JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 increases expression EXP 2,5-hexanedione results in increased expression of STYXL1 mRNA CTD PMID:22952946 NCBI chr12:20,907,410...20,940,232
Ensembl chr12:20,907,435...20,939,752
JBrowse link
G Tax1bp1 Tax1 binding protein 1 increases expression EXP 2,5-hexanedione results in increased expression of TAX1BP1 mRNA CTD PMID:22952946 NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100
JBrowse link
G Tbc1d5 TBC1 domain family, member 5 increases expression EXP 2,5-hexanedione results in increased expression of TBC1D5 mRNA CTD PMID:22952946 NCBI chr 9:3,503,328...4,017,131
Ensembl chr 9:3,513,623...4,016,913
JBrowse link
G Tmem192 transmembrane protein 192 increases expression EXP 2,5-hexanedione results in increased expression of TMEM192 mRNA CTD PMID:22952946 NCBI chr16:24,740,166...24,760,994
Ensembl chr16:24,740,124...24,761,021
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of TNF mRNA] CTD PMID:32522579 PMID:32860822 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP 2,5-hexanedione results in increased expression of TPI1 mRNA; 2,5-hexanedione results in increased expression of TPI1 protein CTD PMID:19033394 PMID:22952946 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 increases expression EXP 2,5-hexanedione results in increased expression of UBA1 protein CTD PMID:19033394 NCBI chr  X:1,508,700...1,530,677
Ensembl chr  X:1,508,666...1,530,636
JBrowse link
G Ubn2 ubinuclein 2 increases expression EXP 2,5-hexanedione results in increased expression of UBN2 mRNA CTD PMID:22952946 NCBI chr 4:67,165,278...67,251,562
Ensembl chr 4:67,166,346...67,230,491
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 decreases expression EXP 2,5-hexanedione results in decreased expression of UQCRC2 mRNA CTD PMID:22952946 NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
JBrowse link
G Vim vimentin multiple interactions ISO 2,5-hexanedione promotes the reaction [VIM protein binds to VIM protein] CTD PMID:6361548 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression EXP 2,5-hexanedione results in decreased expression of XIAP mRNA CTD PMID:22337490 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Zfp169 zinc finger protein 169 decreases expression EXP 2,5-hexanedione results in decreased expression of ZFP169 protein CTD PMID:19033394 NCBI chr17:16,139,204...16,167,242
Ensembl chr17:16,139,253...16,169,914
JBrowse link
G Zfp407 zinc finger protein 407 increases expression EXP 2,5-hexanedione results in increased expression of ZFP407 mRNA CTD PMID:22952946 NCBI chr18:77,571,140...77,970,282
Ensembl chr18:77,571,204...77,974,129
JBrowse link
4,6-dioxoheptanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas1 5'-aminolevulinate synthase 1 multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [succinylacetone results in increased expression of ALAS1 mRNA]
succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]
CTD PMID:21659532 PMID:22859313 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression
multiple interactions
ISO succinylacetone results in increased expression of CYP2A5 mRNA
NFE2L2 gene mutant form affects the reaction [succinylacetone results in increased expression of CYP2A5 mRNA]
CTD PMID:22859313 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO succinylacetone results in increased expression of HMOX1 mRNA CTD PMID:22859313 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 gene mutant form affects the reaction [succinylacetone results in increased expression of CYP2A5 mRNA]; NFE2L2 gene mutant form inhibits the reaction [succinylacetone results in increased expression of ALAS1 mRNA] CTD PMID:22859313 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO succinylacetone results in increased expression of PPARGC1A mRNA CTD PMID:22859313 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
acetylacetonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mt1 metallothionein 1 increases expression ISO acetyl acetonate analog results in increased expression of MT1 mRNA CTD PMID:23085594 NCBI chr19:10,826,032...10,827,048 JBrowse link
benzil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhrs3 dehydrogenase/reductase 3 increases metabolic processing ISO DHRS3 protein results in increased metabolism of benzil CTD PMID:25451588 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of benzil CTD PMID:24246760 NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases activity ISO benzil results in decreased activity of EPHX2 protein CTD PMID:3621371 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
bisdemethoxycurcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO bis(4-hydroxycinnamoyl)methane results in decreased activity of ABCC1 protein; curcumin III results in decreased activity of ABCC1 protein CTD PMID:15885658 PMID:16021489 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO bis(4-hydroxycinnamoyl)methane results in decreased activity of ABCC2 protein CTD PMID:15885658 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO bis(4-hydroxycinnamoyl)methane results in increased phosphorylation of AKT1 protein
AKT1 protein affects the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA]
CTD PMID:17535857 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of MGAT3 mRNA; [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of TLR2 mRNA; [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of TLR3 mRNA; [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of TLR4 mRNA; [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of VDR mRNA; [bis(4-hydroxycinnamoyl)methane co-treated with APP protein] results in increased expression of MGAT3 mRNA; [bis(4-hydroxycinnamoyl)methane co-treated with APP protein] results in increased expression of TLR2 mRNA; [bis(4-hydroxycinnamoyl)methane co-treated with APP protein] results in increased expression of TLR3 mRNA; [bis(4-hydroxycinnamoyl)methane co-treated with APP protein] results in increased expression of TLR4 mRNA; bis(4-hydroxycinnamoyl)methane inhibits the reaction [APP protein binds to APP protein] CTD PMID:19715544 PMID:22029407 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions
ISO bis(4-hydroxycinnamoyl)methane results in increased expression of CD36 mRNA
bis(4-hydroxycinnamoyl)methane inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]
CTD PMID:23386263 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO bis(4-hydroxycinnamoyl)methane results in increased expression of GCLM mRNA; bis(4-hydroxycinnamoyl)methane results in increased expression of GCLM protein CTD PMID:17535857 PMID:19188863 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA; bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 protein
[demethoxycurcumin co-treated with bis(4-hydroxycinnamoyl)methane] results in increased expression of HMOX1 mRNA; AKT1 protein affects the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA]; KEAP1 protein inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA]; PRKCD protein affects the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 protein]
CTD PMID:17535857 PMID:19188863 PMID:23386263 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO KEAP1 protein inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA] CTD PMID:17535857 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO bis(4-hydroxycinnamoyl)methane results in increased phosphorylation of MAPK1 protein CTD PMID:17535857 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO bis(4-hydroxycinnamoyl)methane results in increased phosphorylation of MAPK3 protein CTD PMID:17535857 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mgat3 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase multiple interactions
increases expression
ISO [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of MGAT3 mRNA; [bis(4-hydroxycinnamoyl)methane co-treated with APP protein] results in increased expression of MGAT3 mRNA
bis(4-hydroxycinnamoyl)methane results in increased expression of MGAT3 mRNA
CTD PMID:19090986 PMID:22029407 NCBI chr 7:111,708,353...111,761,825
Ensembl chr 7:111,675,730...111,762,026
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression ISO bis(4-hydroxycinnamoyl)methane results in decreased expression of MMP14 protein CTD PMID:18495463 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO bis(4-hydroxycinnamoyl)methane results in decreased secretion of and results in decreased activity of MMP2 protein modified form CTD PMID:18495463 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO bis(4-hydroxycinnamoyl)methane results in decreased secretion of and results in decreased activity of MMP9 protein CTD PMID:18495463 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO bis(4-hydroxycinnamoyl)methane inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:23386263 NCBI chr16:52,717,775...52,802,890
Ensembl chr16:52,717,732...52,799,676
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions
ISO bis(4-hydroxycinnamoyl)methane affects the localization of NFE2L2 protein
[demethoxycurcumin co-treated with bis(4-hydroxycinnamoyl)methane] affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA]
CTD PMID:17535857 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO bis(4-hydroxycinnamoyl)methane inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:18449507 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
bis(4-hydroxycinnamoyl)methane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; bis(4-hydroxycinnamoyl)methane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:18449507 PMID:18481332 PMID:18838107 PMID:19188055 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO bis(4-hydroxycinnamoyl)methane results in increased expression of NQO1 mRNA; bis(4-hydroxycinnamoyl)methane results in increased expression of NQO1 protein CTD PMID:17535857 PMID:19188863 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Plau plasminogen activator, urokinase decreases secretion ISO bis(4-hydroxycinnamoyl)methane results in decreased secretion of PLAU protein CTD PMID:18495463 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding ISO bis(4-hydroxycinnamoyl)methane binds to PPARG protein CTD PMID:15713005 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO PRKCD protein affects the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA] CTD PMID:17535857 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO bis(4-hydroxycinnamoyl)methane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; bis(4-hydroxycinnamoyl)methane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:18449507 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression ISO bis(4-hydroxycinnamoyl)methane results in decreased expression of TIMP2 protein CTD PMID:18495463 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of TLR2 mRNA; [bis(4-hydroxycinnamoyl)methane co-treated with APP protein] results in increased expression of TLR2 mRNA CTD PMID:22029407 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of TLR3 mRNA; [bis(4-hydroxycinnamoyl)methane co-treated with APP protein] results in increased expression of TLR3 mRNA CTD PMID:22029407 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of TLR4 mRNA; [bis(4-hydroxycinnamoyl)methane co-treated with APP protein] results in increased expression of TLR4 mRNA CTD PMID:22029407 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP bis(4-hydroxycinnamoyl)methane inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; bis(4-hydroxycinnamoyl)methane inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:18838107 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of VDR mRNA CTD PMID:22029407 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Wt1 WT1 transcription factor decreases expression ISO bis(4-hydroxycinnamoyl)methane results in decreased expression of WT1 mRNA; bis(4-hydroxycinnamoyl)methane results in decreased expression of WT1 protein CTD PMID:18034345 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
JBrowse link
butane-2,3-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B increases reduction
multiple interactions
ISO AKR1B1 protein results in increased reduction of Diacetyl
[AKR1B1 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin
CTD PMID:23295224 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases reduction
multiple interactions
ISO AKR1B10 protein results in increased reduction of Diacetyl
[AKR1B10 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin
CTD PMID:23295224 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of Diacetyl CTD PMID:18845131 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Alb albumin affects binding ISO
EXP
Diacetyl binds to ALB protein CTD PMID:25559854 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO Diacetyl results in increased expression of ALDH1A3 mRNA CTD PMID:30710127 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 decreases expression ISO Diacetyl results in decreased expression of ALDH7A1 protein CTD PMID:34031698 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
JBrowse link
G Areg amphiregulin increases secretion ISO Diacetyl results in increased secretion of AREG protein CTD PMID:30851105 PMID:31381966 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G B3gat3 beta-1,3-glucuronyltransferase 3 decreases activity
multiple interactions
ISO Diacetyl results in decreased activity of B3GAT3 protein
Uridine Diphosphate Glucuronic Acid inhibits the reaction [Diacetyl results in decreased activity of B3GAT3 protein]
CTD PMID:11986319 NCBI chr 1:205,817,374...205,823,928 JBrowse link
G Cc2d2a coiled-coil and C2 domain containing 2A decreases expression ISO Diacetyl results in decreased expression of CC2D2A mRNA CTD PMID:30710127 NCBI chr14:67,349,004...67,435,883
Ensembl chr14:67,351,353...67,435,949
JBrowse link
G Cdc20b cell division cycle 20B decreases expression ISO Diacetyl results in decreased expression of CDC20B mRNA CTD PMID:30710127 NCBI chr 2:44,688,349...44,738,056 JBrowse link
G Cfap221 cilia and flagella associated protein 221 decreases expression ISO Diacetyl results in decreased expression of CFAP221 mRNA CTD PMID:30710127 NCBI chr13:31,046,550...31,118,141
Ensembl chr13:31,046,535...31,116,899
JBrowse link
G Cfap70 cilia and flagella associated protein 70 decreases expression ISO Diacetyl results in decreased expression of CFAP70 mRNA CTD PMID:30710127 NCBI chr15:3,852,381...3,918,036
Ensembl chr15:3,852,509...3,918,014
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression
multiple interactions
EXP Diacetyl results in increased expression of CXCL1 mRNA
Diacetyl results in increased expression of and results in increased secretion of CXCL1 protein
CTD PMID:25145656 PMID:30851105 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions ISO 1,2-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; 1,4-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; 9,10-phenanthrenequinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; [[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin; [DCXR protein co-treated with NAD] results in increased reduction of Diacetyl; [DCXR protein co-treated with NADP] results in increased reduction of Diacetyl; Butyric Acid inhibits the reaction [[DCXR protein co-treated with NADP] results in increased reduction of Diacetyl]; Diacetyl inhibits the reaction [[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides]; Heptanoic Acids inhibits the reaction [[DCXR protein co-treated with NADP] results in increased reduction of Diacetyl]; hexanoic acid inhibits the reaction [[DCXR protein co-treated with NADP] results in increased reduction of Diacetyl]; Pentanoic Acids inhibits the reaction [[DCXR protein co-treated with NADP] results in increased reduction of Diacetyl]; Vitamin K 3 inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin] CTD PMID:28595002 NCBI chr10:106,006,404...106,008,294 JBrowse link
G Dhrs9 dehydrogenase/reductase 9 increases expression ISO Diacetyl results in increased expression of DHRS9 mRNA CTD PMID:30710127 NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241
JBrowse link
G Dnaaf1 dynein, axonemal, assembly factor 1 decreases expression ISO Diacetyl results in decreased expression of DNAAF1 mRNA CTD PMID:30710127 NCBI chr19:47,624,534...47,652,314
Ensembl chr19:47,624,181...47,652,313
JBrowse link
G Dnah12 dynein, axonemal, heavy chain 12 decreases expression ISO Diacetyl results in decreased expression of DNAH12 mRNA CTD PMID:30710127 NCBI chr16:1,936,354...2,092,663
Ensembl chr16:1,937,817...2,092,664
JBrowse link
G Dnah3 dynein, axonemal, heavy chain 3 decreases expression ISO Diacetyl results in decreased expression of DNAH3 mRNA CTD PMID:30710127 NCBI chr 1:174,305,929...174,479,490 JBrowse link
G Dnah6 dynein, axonemal, heavy chain 6 decreases expression ISO Diacetyl results in decreased expression of DNAH6 mRNA CTD PMID:30710127 NCBI chr 4:105,064,123...105,284,361
Ensembl chr 4:105,064,125...105,284,376
JBrowse link
G Dnai1 dynein, axonemal, intermediate chain 1 decreases expression ISO Diacetyl results in decreased expression of DNAI1 mRNA CTD PMID:30710127 NCBI chr 5:56,730,179...56,800,926
Ensembl chr 5:56,730,179...56,800,925
JBrowse link
G Dsp desmoplakin decreases expression ISO Diacetyl results in decreased expression of DSP protein CTD PMID:34031698 NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [Diacetyl results in increased phosphorylation of EGFR protein] CTD PMID:30851105 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP Diacetyl results in increased expression of GCLC mRNA CTD PMID:25145656 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression ISO Diacetyl results in increased expression of GSTA1 mRNA CTD PMID:31381966 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases secretion ISO Diacetyl results in increased secretion of HBEGF protein CTD PMID:30851105 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Diacetyl results in increased expression of HMOX1 mRNA CTD PMID:25145656 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il6 interleukin 6 affects expression
decreases expression
increases expression
ISO
EXP
Diacetyl analog affects the expression of IL6 mRNA
Diacetyl results in decreased expression of IL6 mRNA
Diacetyl results in increased expression of IL6 mRNA
CTD PMID:20200221 PMID:25145656 PMID:31381966 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression ISO Diacetyl results in decreased expression of ITGA6 protein CTD PMID:34031698 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428
JBrowse link
G Itgav integrin subunit alpha V decreases expression ISO Diacetyl results in decreased expression of ITGAV protein CTD PMID:34031698 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO Diacetyl results in decreased expression of ITGB4 protein CTD PMID:34031698 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
JBrowse link
G Krt19 keratin 19 decreases expression ISO Diacetyl results in decreased expression of KRT19 protein CTD PMID:34031698 NCBI chr10:85,075,835...85,080,552 JBrowse link
G Krt5 keratin 5 multiple interactions ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [Diacetyl affects the expression of and affects the ubiquitination of KRT5 protein]; Diacetyl affects the expression of and affects the ubiquitination of KRT5 protein CTD PMID:32112875 NCBI chr 7:132,846,355...132,851,986
Ensembl chr 7:132,846,136...132,851,850
JBrowse link
G Macrod2 mono-ADP ribosylhydrolase 2 decreases expression ISO Diacetyl results in decreased expression of MACROD2 mRNA CTD PMID:30710127 NCBI chr 3:127,720,066...129,737,511 JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Diacetyl results in increased phosphorylation of MAPK1 protein
RTKI cpd inhibits the reaction [Diacetyl results in increased phosphorylation of MAPK1 protein]
CTD PMID:30851105 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Diacetyl results in increased phosphorylation of MAPK3 protein
RTKI cpd inhibits the reaction [Diacetyl results in increased phosphorylation of MAPK3 protein]
CTD PMID:30851105 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases secretion
increases expression
ISO Diacetyl results in increased secretion of MMP9 protein
Diacetyl results in increased expression of MMP9 mRNA
CTD PMID:31381966 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization EXP Diacetyl affects the localization of NFE2L2 protein CTD PMID:25145656 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO Diacetyl results in increased expression of NFKB1 mRNA CTD PMID:31381966 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression ISO Diacetyl results in decreased expression of NNT protein CTD PMID:34031698 NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 decreases expression ISO Diacetyl results in decreased expression of PAPSS2 mRNA CTD PMID:30710127 NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331
JBrowse link
G Pkp1 plakophilin 1 decreases expression ISO Diacetyl results in decreased expression of PKP1 protein CTD PMID:34031698 NCBI chr13:47,309,603...47,357,551
Ensembl chr13:47,309,614...47,357,465
JBrowse link
G Prom1 prominin 1 decreases expression ISO Diacetyl results in decreased expression of PROM1 mRNA CTD PMID:30710127 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G Psmb5 proteasome 20S subunit beta 5 increases expression ISO Diacetyl results in increased expression of PSMB5 protein CTD PMID:34031698 NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
JBrowse link
G Psmc1 proteasome 26S subunit, ATPase 1 increases expression ISO Diacetyl results in increased expression of PSMC1 protein CTD PMID:34031698 NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123
JBrowse link
G Ptges2 prostaglandin E synthase 2 increases expression ISO Diacetyl results in increased expression of PTGES2 mRNA CTD PMID:31381966 NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Diacetyl results in decreased expression of PTGS2 mRNA CTD PMID:30710127 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pthlh parathyroid hormone-like hormone decreases expression ISO Diacetyl results in decreased expression of PTHLH mRNA CTD PMID:30710127 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 decreases expression EXP Diacetyl results in decreased expression of SCGB1A1 protein CTD PMID:21464978 NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases secretion
affects expression
ISO Diacetyl results in increased secretion of SLPI protein
Diacetyl affects the expression of SLPI mRNA
CTD PMID:31381966 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Sorcs2 sortilin-related VPS10 domain containing receptor 2 decreases expression ISO Diacetyl results in decreased expression of SORCS2 mRNA CTD PMID:30710127 NCBI chr14:74,371,089...74,735,943
Ensembl chr14:74,371,415...74,735,943
JBrowse link
G Spag17 sperm associated antigen 17 decreases expression ISO Diacetyl results in decreased expression of SPAG17 mRNA CTD PMID:30710127 NCBI chr 2:187,264,004...187,511,061
Ensembl chr 2:187,264,009...187,510,501
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Diacetyl results in increased expression of SQSTM1 protein CTD PMID:34031698 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tax1bp3 Tax1 binding protein 3 increases expression ISO Diacetyl results in increased expression of TAX1BP3 mRNA CTD PMID:30710127 NCBI chr10:57,795,785...57,800,363
Ensembl chr10:57,795,382...57,800,363
JBrowse link
G Tekt1 tektin 1 decreases expression ISO Diacetyl results in decreased expression of TEKT1 mRNA CTD PMID:30710127 NCBI chr10:56,952,164...56,980,572
Ensembl chr10:56,952,167...56,980,572
JBrowse link
G Tgfa transforming growth factor alpha increases secretion ISO Diacetyl results in increased secretion of TGFA protein CTD PMID:30851105 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tnc tenascin C increases expression EXP Diacetyl results in increased expression of TNC protein CTD PMID:21464978 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Diacetyl results in increased expression of TNF mRNA CTD PMID:31381966 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp63 tumor protein p63 affects expression ISO Diacetyl affects the expression of TP63 protein alternative form CTD PMID:32112875 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link
G Trip12 thyroid hormone receptor interactor 12 increases expression ISO Diacetyl results in increased expression of TRIP12 protein CTD PMID:34031698 NCBI chr 9:85,916,691...86,043,312
Ensembl chr 9:85,916,691...86,051,403
JBrowse link
G Ubc ubiquitin C increases expression EXP Diacetyl results in increased expression of UBC protein CTD PMID:34031698 NCBI chr12:31,238,889...31,243,924
Ensembl chr12:31,239,152...31,243,925
JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression ISO Diacetyl results in increased expression of UBE2L3 protein CTD PMID:34031698 NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862
JBrowse link
G Uchl5 ubiquitin C-terminal hydrolase L5 increases expression ISO Diacetyl results in increased expression of UCHL5 protein CTD PMID:34031698 NCBI chr13:55,520,722...55,556,503
Ensembl chr13:55,520,729...55,556,502
JBrowse link
G Usp14 ubiquitin specific peptidase 14 increases expression ISO Diacetyl results in increased expression of USP14 protein CTD PMID:34031698 NCBI chr18:1,018,111...1,057,727
Ensembl chr18:1,019,400...1,057,519
JBrowse link
curcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A4galt alpha 1,4-galactosyltransferase (P blood group) multiple interactions ISO Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA] CTD PMID:16819191 NCBI chr 7:114,368,525...114,392,872
Ensembl chr 7:114,368,276...114,396,071
JBrowse link
G Aars1 alanyl-tRNA synthetase 1 decreases expression ISO Curcumin results in decreased expression of AARS1 mRNA CTD PMID:17198877 NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
decreases response to substance
decreases expression
multiple interactions
ISO ABCB1 affects the susceptibility to Curcumin
ABCB1 protein results in decreased susceptibility to Curcumin
Curcumin analog results in decreased expression of ABCB1 protein; Curcumin results in decreased expression of ABCB1 mRNA; Curcumin results in decreased expression of ABCB1B mRNA
[Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Calcitriol promotes the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ABCB1 mRNA]
[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; [Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein; [sulfinosine co-treated with Curcumin] results in decreased expression of ABCB1 mRNA; Calcitriol inhibits the reaction [[Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin results in decreased expression of and results in decreased activity of ABCB1 protein
CTD PMID:15476675 PMID:17121181 PMID:18200517 PMID:18385293 PMID:18414057 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Curcumin results in decreased expression of ABCB1B protein]; [Curcumin results in decreased expression of ABCB1B protein] which results in increased susceptibility to Doxorubicin; Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]
Curcumin results in decreased expression of ABCB1B mRNA; Curcumin results in decreased expression of ABCB1B protein
CTD PMID:18006147 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
decreases expression
ISO Curcumin results in decreased activity of ABCC1 protein
Curcumin analog results in decreased expression of ABCC1 mRNA
CTD PMID:15885658 PMID:16021489 PMID:26409325 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO Curcumin results in decreased activity of ABCC2 protein CTD PMID:15885658 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO [Curcumin analog binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; [Curcumin binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; Curcumin analog binds to and results in decreased activity of ABCC5 protein; Curcumin analog inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]; Curcumin binds to and results in decreased activity of ABCC5 protein; Curcumin inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid] CTD PMID:23978416 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Curcumin results in increased expression of ABCG1 mRNA CTD PMID:16713233 PMID:21594647 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases expression
increases expression
ISO AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein]
Curcumin results in decreased expression of ABCG2 mRNA
CTD PMID:17077187 PMID:33539684 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation
decreases expression
affects expression
multiple interactions
ISO
EXP
Curcumin results in increased phosphorylation of ACACA protein
Curcumin results in decreased expression of ACACA mRNA
Curcumin affects the expression of ACACA mRNA
Curcumin inhibits the reaction [Dietary Fats results in decreased phosphorylation of ACACA protein]
CTD PMID:18790744 PMID:19297423 PMID:27208389 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein] CTD PMID:10666014 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions EXP Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein] CTD PMID:26648693 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
Curcumin results in decreased activity of ACHE protein
Curcumin inhibits the reaction [Acrylamide results in increased activity of ACHE protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
CTD PMID:18809455 PMID:20369229 PMID:21839772 PMID:22783142 PMID:25199698 More... NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ackr3 atypical chemokine receptor 3 increases expression ISO Curcumin results in increased expression of ACKR3 mRNA CTD PMID:21594647 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
JBrowse link
G Acly ATP citrate lyase affects expression
decreases expression
ISO
EXP
Curcumin affects the expression of ACLY mRNA
Curcumin results in decreased expression of ACLY mRNA
CTD PMID:27208389 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Aco2 aconitase 2 multiple interactions EXP Curcumin inhibits the reaction [Potassium Dichromate results in decreased activity of ACO2 protein] CTD PMID:25130536 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
EXP
ISO
Curcumin results in decreased expression of ACTA2 mRNA; Curcumin results in decreased expression of ACTA2 protein
Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Arsenic Trioxide promotes the reaction [Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]
CTD PMID:17355460 PMID:17531121 PMID:18006644 PMID:22683883 PMID:27363783 More... NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA] CTD PMID:17666914 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 increases expression ISO Curcumin results in increased expression of ADAMTS4 mRNA CTD PMID:18321735 NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065
JBrowse link
G Adcy9 adenylate cyclase 9 decreases expression ISO Curcumin results in decreased expression of ADCY9 mRNA CTD PMID:15713895 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 decreases expression ISO Curcumin results in decreased expression of ADGRE1 mRNA CTD PMID:18403477 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
multiple interactions
affects expression
ISO
EXP
Curcumin results in increased expression of ADIPOQ mRNA; Curcumin results in increased expression of ADIPOQ protein
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]]
Curcumin affects the expression of ADIPOQ mRNA
Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]
CTD PMID:18403477 PMID:26713546 PMID:27208389 PMID:28595985 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adora2a adenosine A2a receptor multiple interactions ISO [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]; Curcumin inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA] CTD PMID:31820278 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein] CTD PMID:29480285 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member decreases expression ISO Curcumin results in decreased expression of AGR2 mRNA CTD PMID:17198877 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
JBrowse link
G Agt angiotensinogen multiple interactions EXP
ISO
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD2 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD3 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of AGT protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of AGT protein]
CTD PMID:26612707 PMID:26648693 PMID:31820278 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein] CTD PMID:26648693 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects binding
increases degradation
ISO AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein]
Curcumin binds to AHR protein
Curcumin results in increased degradation of AHR protein
[Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene affects the localization of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of AHR protein]; Curcumin inhibits the reaction [Methylcholanthrene binds to AHR protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]; Curcumin promotes the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
CTD PMID:17077187 PMID:17880909 PMID:18321868 PMID:19018768 PMID:25632966 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ak1 adenylate kinase 1 multiple interactions ISO [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein CTD PMID:25866362 NCBI chr 3:15,912,431...15,923,045 JBrowse link
G Akap6 A-kinase anchoring protein 6 increases expression
multiple interactions
ISO Curcumin results in increased expression of AKAP6 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA]
CTD PMID:18200517 PMID:18421014 NCBI chr 6:70,184,101...70,624,369
Ensembl chr 6:70,184,175...70,619,738
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression
multiple interactions
increases activity
ISO
EXP
Curcumin results in increased expression of AKR1B1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]
Curcumin results in increased expression of AKR1B1 mRNA; Curcumin results in increased expression of AKR1B1 protein
Curcumin results in increased activity of AKR1B1 protein
CTD PMID:17640564 PMID:18200517 PMID:18299980 PMID:18588981 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP Curcumin results in increased expression of AKR1B8 mRNA CTD PMID:18299980 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
affects phosphorylation
decreases expression
decreases phosphorylation
increases expression
increases phosphorylation
decreases activity
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Curcumin inhibits the reaction [stearic acid results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]
Curcumin affects the phosphorylation of AKT1 protein
Curcumin analog results in decreased expression of AKT1 mRNA; Curcumin results in decreased expression of AKT1 protein
Curcumin results in increased expression of AKT1 protein
AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of AKT1 protein
AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]
Curcumin results in decreased activity of AKT1 protein
CTD PMID:16023083 PMID:16219905 PMID:17289836 PMID:17291458 PMID:17332930 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]
Curcumin analog results in decreased expression of AKT2 mRNA
CTD PMID:23452621 PMID:26409325 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions EXP
ISO
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of ALAD protein]
Curcumin inhibits the reaction [lead acetate results in decreased activity of ALAD protein]
CTD PMID:22704994 PMID:23292317 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression EXP Curcumin results in increased expression of ALAS1 mRNA CTD PMID:18299980 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Alb albumin multiple interactions EXP [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of ALB protein]; [Curcumin analog co-treated with Hydrogels] results in increased expression of ALB protein; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ALB protein] CTD PMID:18204486 PMID:18809455 PMID:20804811 PMID:24704557 PMID:27288928 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Alcam activated leukocyte cell adhesion molecule decreases expression ISO Curcumin results in decreased expression of ALCAM mRNA CTD PMID:33539684 NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
decreases expression
ISO [Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 mRNA]; [Calcitriol co-treated with Paclitaxel] promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; [Curcumin co-treated with Paclitaxel] promotes the reaction [Calcitriol results in decreased expression of ALDH1A1 mRNA]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; Paclitaxel promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]
[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]
Curcumin results in decreased expression of ALDH1A1 mRNA; Curcumin results in decreased expression of ALDH1A1 protein
CTD PMID:31628941 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A decreases expression ISO Curcumin results in decreased expression of ALDOA mRNA CTD PMID:16880289 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO Curcumin results in decreased expression of ALDOC mRNA CTD PMID:17198877 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
decreases activity
EXP [Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 protein
Curcumin results in decreased activity of ALOX5 protein
CTD PMID:16956363 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression EXP Curcumin results in increased expression of AMPD3 mRNA CTD PMID:18299980 NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression ISO Curcumin results in decreased expression of ANKRD37 mRNA CTD PMID:17198877 NCBI chr16:46,269,025...46,271,971
Ensembl chr16:46,268,443...46,271,963
JBrowse link
G Ankrd50 ankyrin repeat domain 50 decreases expression ISO Curcumin results in decreased expression of ANKRD50 mRNA CTD PMID:17999991 NCBI chr 2:121,466,275...121,500,758
Ensembl chr 2:121,468,573...121,500,752
JBrowse link
G Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 decreases expression ISO Curcumin results in decreased expression of ANKZF1 mRNA CTD PMID:17198877 NCBI chr 9:76,688,223...76,695,141
Ensembl chr 9:76,688,194...76,696,469
JBrowse link
G Aoc1 amine oxidase, copper containing 1 multiple interactions EXP Curcumin inhibits the reaction [Methotrexate results in increased activity of AOC1 protein] CTD PMID:20885979 NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of APAF1 protein
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA]
CTD PMID:17277231 PMID:20869986 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Apc APC regulator of WNT signaling pathway decreases expression ISO Curcumin results in decreased expression of APC mRNA CTD PMID:15713895 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Apoe apolipoprotein E affects expression ISO Curcumin affects the expression of APOE mRNA CTD PMID:27208389 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases expression
ISO
EXP
Curcumin affects the reaction [APP protein binds to APP protein]; Curcumin inhibits the reaction [Copper results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP protein]
Curcumin results in increased expression of APP mRNA
[Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]
CTD PMID:18537544 PMID:18583042 PMID:27793699 PMID:30946834 PMID:31521693 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) decreases expression
multiple interactions
ISO Curcumin results in decreased expression of AQP3 protein
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]
CTD PMID:18214481 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
decreases activity
decreases expression
ISO [[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR mRNA; [[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR protein; [Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin promotes the reaction [Quercetin results in increased expression of AR mRNA]; Curcumin promotes the reaction [Quercetin results in increased expression of AR protein]; Quercetin promotes the reaction [Curcumin results in increased expression of AR mRNA]; Quercetin promotes the reaction [Curcumin results in increased expression of AR protein]
Curcumin results in increased expression of AR mRNA; Curcumin results in increased expression of AR protein
Curcumin results in decreased activity of AR protein
Curcumin results in decreased expression of AR mRNA; Curcumin results in decreased expression of AR protein
CTD PMID:12497104 PMID:18676361 PMID:18719366 PMID:22258452 PMID:27132804 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arhgap24 Rho GTPase activating protein 24 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA] CTD PMID:18200517 NCBI chr14:6,800,631...7,184,001
Ensembl chr14:6,800,631...7,183,823
JBrowse link
G Arhgap30 Rho GTPase activating protein 30 decreases expression ISO Curcumin results in decreased expression of ARHGAP30 mRNA CTD PMID:18421014 NCBI chr13:83,822,290...83,843,634
Ensembl chr13:83,822,283...83,854,885
JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARHGDIB mRNA] CTD PMID:18200517 NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions
increases degradation
decreases expression
ISO Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; Curcumin results in increased ubiquitination of and results in increased degradation of ARNT protein
Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
Curcumin results in decreased expression of ARNT protein
CTD PMID:16880289 PMID:17880909 PMID:18682687 PMID:19018768 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA] CTD PMID:23452621 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
JBrowse link
G Atf2 activating transcription factor 2 decreases expression ISO Curcumin analog results in decreased expression of ATF2 mRNA CTD PMID:26409325 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Curcumin results in increased expression of ATF3 mRNA; Curcumin results in increased expression of ATF3 protein CTD PMID:15713895 PMID:18555241 PMID:18719366 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Curcumin results in increased expression of ATF6 protein
Curcumin results in increased expression of ATF6 mRNA
CTD PMID:21793155 PMID:29723631 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
increases phosphorylation
ISO [Isoflavones co-treated with Curcumin] results in increased phosphorylation of ATM protein
Curcumin results in increased phosphorylation of ATM protein
CTD PMID:19401701 PMID:21134073 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Aurka aurora kinase A decreases expression ISO Curcumin analog results in decreased expression of AURKA mRNA CTD PMID:26409325 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Curcumin analog results in decreased expression of AURKB mRNA CTD PMID:26409325 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Axin1 axin 1 multiple interactions
increases expression
EXP Curcumin inhibits the reaction [bisphenol A results in decreased expression of AXIN1 mRNA]
Curcumin results in increased expression of AXIN1 mRNA
CTD PMID:25963729 NCBI chr10:15,163,684...15,215,615
Ensembl chr10:15,163,684...15,215,615
JBrowse link
G B3galt6 Beta-1,3-galactosyltransferase 6 increases expression ISO Curcumin results in increased expression of B3GALT6 mRNA CTD PMID:17198877 NCBI chr 5:166,584,202...166,586,338
Ensembl chr 5:166,584,202...166,586,338
JBrowse link
G Bace1 beta-secretase 1 multiple interactions
increases expression
ISO Curcumin inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of BACE1 mRNA]
Curcumin results in increased expression of BACE1 mRNA
CTD PMID:18583042 PMID:31521693 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of BAD mRNA; Curcumin results in increased expression of BAD protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of BAD protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAD protein]
CTD PMID:15569404 PMID:19235267 PMID:27430728 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
decreases expression
increases expression
increases response to substance
ISO TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein]
Curcumin results in decreased expression of BAK1 mRNA
Curcumin results in increased expression of BAK1 mRNA; Curcumin results in increased expression of BAK1 protein
BAK1 protein results in increased susceptibility to Curcumin
CTD PMID:17277231 PMID:17332930 PMID:18226269 PMID:33582110 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
increases expression
affects localization
increases response to substance
ISO
EXP
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of BAX protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Sirolimus] results in increased expression of BAX; [Doxorubicin co-treated with Curcumin] results in increased expression of BAX mRNA; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; Arsenic Trioxide promotes the reaction [Curcumin affects the localization of BAX protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of BAX protein]; Curcumin promotes the reaction [Arsenic Trioxide affects the localization of BAX protein]; Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Curcumin promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of BAX protein]; piperine inhibits the reaction [Curcumin results in decreased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of BAX protein]
Curcumin results in decreased expression of BAX mRNA; Curcumin results in decreased expression of BAX protein
Curcumin results in increased expression of BAX mRNA; Curcumin results in increased expression of BAX protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of BAX mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of BAX protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]
BAX protein results in increased susceptibility to Curcumin
Curcumin affects the localization of and results in increased expression of and results in increased activity of BAX protein
CTD PMID:15569404 PMID:17096185 PMID:17277231 PMID:17332930 PMID:17531121 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression
multiple interactions
decreases expression
ISO
EXP
Curcumin results in increased expression of BBC3 mRNA
Curcumin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein]
Curcumin results in decreased expression of BBC3 mRNA
CTD PMID:17332930 PMID:22714040 PMID:34047412 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl10 BCL10, immune signaling adaptor multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL10 mRNA] CTD PMID:23452621 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression
ISO
EXP
[Arsenic Trioxide co-treated with Curcumin] affects the expression of BCL2 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in decreased expression of BCL2 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2 protein; [Curcumin co-treated with Sirolimus] results in decreased expression of BCL2; [Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein; [Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of BCL2 protein; [Doxorubicin co-treated with Curcumin] results in decreased expression of BCL2 mRNA; [piperine co-treated with Curcumin] results in decreased expression of BCL2 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of BCL2 protein; Curcumin inhibits the reaction [Docetaxel results in increased phosphorylation of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin promotes the reaction [Calcitriol promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein]
Curcumin results in increased expression of BCL2 mRNA; Curcumin results in increased expression of BCL2 protein
Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein
Curcumin analog results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of BCL2 protein; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in increased expression of BCL2 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BCL2 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]
CTD PMID:12497104 PMID:14724571 PMID:15569404 PMID:16023083 PMID:16219905 More... NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]
Curcumin results in decreased expression of BCL2A1 mRNA
CTD PMID:16219905 PMID:17596214 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
increases expression
ISO
EXP
[Curcumin co-treated with Doxorubicin] affects the expression of BCL2L1 mRNA; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2L1 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein]
Curcumin analog results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BCL2L1 protein
Curcumin results in increased expression of BCL2L1 mRNA
CTD PMID:12497104 PMID:15569404 PMID:15911101 PMID:16023083 PMID:16173963 More... NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression
multiple interactions
ISO Curcumin results in increased expression of BCL2L11 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of BCL2L11 protein
CTD PMID:17332930 PMID:27430728 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression
multiple interactions
ISO Curcumin results in increased expression of BCL2L2 mRNA
[arsenic trioxide co-treated with Curcumin] affects the expression of BCL2L2 protein
CTD PMID:16101141 PMID:27430728 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
JBrowse link
G Bcl3 BCL3, transcription coactivator multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BCL3 mRNA]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL3 mRNA]
CTD PMID:18200517 PMID:23452621 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Bcor BCL6 co-repressor increases expression ISO Curcumin results in increased expression of BCOR mRNA CTD PMID:17198877 NCBI chr  X:10,609,756...10,729,613
Ensembl chr  X:10,687,732...10,729,613
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression
affects expression
EXP
ISO
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BDNF protein]
Curcumin results in increased expression of BDNF protein
Curcumin affects the expression of BDNF protein
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of BDNF mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BDNF protein]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]
CTD PMID:17022948 PMID:17617388 PMID:17827730 PMID:19033880 PMID:22911773 More... NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bgn biglycan multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BGN mRNA] CTD PMID:18200517 NCBI chr  X:151,197,296...151,209,458
Ensembl chr  X:151,197,273...151,209,461
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [arsenic trioxide co-treated with Curcumin] results in decreased expression of BID protein; [arsenic trioxide co-treated with Curcumin] results in increased expression of BID protein; Curcumin promotes the reaction [arsenic trioxide results in increased activity of BID protein] CTD PMID:20605902 PMID:27430728 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions
ISO Curcumin analog results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 protein
Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]
CTD PMID:16023083 PMID:16219905 PMID:16243823 PMID:17596214 PMID:17640567 More... NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
increases expression
decreases expression
ISO [arsenic trioxide co-treated with Curcumin] results in decreased expression of BIRC3 protein; [Curcumin co-treated with Doxorubicin] affects the expression of BIRC3 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC3 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]
[Curcumin co-treated with gemcitabine] results in decreased expression of BIRC3 protein
Curcumin results in increased expression of BIRC3 mRNA
Curcumin results in decreased expression of BIRC3 mRNA; Curcumin results in decreased expression of BIRC3 protein
CTD PMID:15911101 PMID:16101141 PMID:16219905 PMID:16243823 PMID:17440100 More... NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO
EXP
[arsenic trioxide co-treated with Curcumin] results in decreased expression of BIRC5 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BIRC5 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC5 protein]
Curcumin inhibits the reaction [Doxorubicin results in decreased expression of BIRC5 protein]
Curcumin analog results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of BIRC5 protein
CTD PMID:16023083 PMID:17440100 PMID:17596214 PMID:17671737 PMID:18593936 More... NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 increases expression
multiple interactions
ISO Curcumin results in increased expression of BIRC7 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of BIRC7 protein
CTD PMID:15911101 PMID:27430728 NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606
JBrowse link
G Bmp2 bone morphogenetic protein 2 decreases expression ISO Curcumin results in decreased expression of BMP2 mRNA CTD PMID:27237783 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bsg basigin (Ok blood group) decreases response to substance ISO BSG protein results in decreased susceptibility to Curcumin CTD PMID:18379992 NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387
JBrowse link
G C1qa complement C1q A chain decreases expression ISO Curcumin results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C1qb complement C1q B chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA] CTD PMID:18200517 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
JBrowse link
G C3 complement C3 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C3 mRNA] CTD PMID:18200517 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C4b complement C4B (Chido blood group) multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA] CTD PMID:18200517 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G Ca9 carbonic anhydrase 9 decreases expression EXP Curcumin results in decreased expression of CAR9 mRNA CTD PMID:18299980 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions ISO
EXP
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CAMK2A mRNA
Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CAMK2A protein]
CTD PMID:22911773 PMID:29723552 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Capg capping actin protein, gelsolin like multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CAPG mRNA] CTD PMID:18200517 NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856
JBrowse link
G Casp1 caspase 1 increases expression
multiple interactions
ISO Curcumin results in increased expression of CASP1 mRNA
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP1 mRNA]
CTD PMID:16101141 PMID:23452621 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of CASP12 protein
Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein]
CTD PMID:21793155 PMID:25541178 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp2 caspase 2 increases expression ISO Curcumin results in increased expression of CASP2 mRNA CTD PMID:16101141 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
increases cleavage
increases activity
decreases activity
increases expression
ISO
EXP
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP3 protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased cleavage of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP3 protein; [Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]]
Curcumin results in decreased expression of CASP3 protein modified form
Curcumin results in increased cleavage of CASP3 protein
Curcumin results in decreased activity of CASP3 protein
[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Curcumin results in decreased cleavage of and results in decreased activity of CASP3 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of CASP3 protein; [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form]
Curcumin results in increased expression of CASP3 mRNA; Curcumin results in increased expression of CASP3 protein; Curcumin results in increased expression of CASP3 protein modified form
Curcumin analog results in increased activity of CASP3 protein; Curcumin results in increased activity of CASP3; Curcumin results in increased activity of CASP3 protein
Curcumin results in decreased expression of CASP3 mRNA; Curcumin results in decreased expression of CASP3 protein
CTD PMID:15095415 PMID:15569404 PMID:16023083 PMID:16101141 PMID:17041101 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 increases expression ISO Curcumin results in increased expression of CASP4 mRNA CTD PMID:16101141 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp7 caspase 7 multiple interactions
increases expression
decreases expression
ISO [Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in increased expression of CASP7 protein]; [Curcumin co-treated with Sirolimus] results in increased activity of CASP7 protein; Calcitriol inhibits the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP7 protein
Curcumin results in increased expression of CASP7 protein
Curcumin results in decreased expression of CASP7 mRNA
CTD PMID:16023083 PMID:16101141 PMID:19373661 PMID:31628941 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
increases cleavage
decreases expression
ISO
EXP
Curcumin results in increased activity of CASP8 protein
Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]
Curcumin results in increased cleavage of CASP8 protein
Curcumin results in decreased expression of CASP8 mRNA; Curcumin results in decreased expression of CASP8 protein
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP8 protein; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]; Curcumin results in increased cleavage of and results in increased activity of CASP8 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Curcumin results in increased cleavage of CASP8 protein]
CTD PMID:14555224 PMID:16173963 PMID:17096185 PMID:17148446 PMID:22523229 More... NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 decreases expression
multiple interactions
increases activity
increases expression
increases cleavage
ISO
EXP
Curcumin results in decreased expression of CASP9 mRNA; Curcumin results in decreased expression of CASP9 protein
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP9 mRNA]
Curcumin results in increased activity of CASP9 protein
Curcumin results in increased expression of CASP9 mRNA; Curcumin results in increased expression of CASP9 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of CASP9 protein; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein
Curcumin results in increased cleavage of CASP9 protein
[Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in increased expression of CASP9 protein]; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP9 protein; [Doxorubicin co-treated with Curcumin] results in increased expression of CASP9 mRNA; [Paclitaxel co-treated with Calcitriol] promotes the reaction [Curcumin results in increased expression of CASP9 protein]; [Paclitaxel co-treated with Curcumin] promotes the reaction [Calcitriol results in increased expression of CASP9 protein]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]; Curcumin promotes the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein; Paclitaxel promotes the reaction [Curcumin results in increased expression of CASP9 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]]
CTD PMID:14555224 PMID:16023083 PMID:16101141 PMID:17148446 PMID:17277231 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression
ISO
EXP
[arsenite co-treated with Curcumin] results in increased expression of CAT protein; Curcumin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Vehicle Emissions promotes the reaction [Cisplatin results in decreased activity of CAT protein]]; Curcumin inhibits the reaction [Vehicle Emissions results in decreased activity of CAT protein]
Curcumin results in increased activity of CAT protein
Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chloranil results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT]; Curcumin metabolite inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; sodium arsenite inhibits the reaction [Curcumin results in increased activity of CAT protein]
Curcumin results in increased expression of CAT mRNA
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of CAT protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acrylonitrile results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Oxygen deficiency results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT protein]
CTD PMID:16770732 PMID:17076682 PMID:17351913 PMID:17461496 PMID:18299980 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO [[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; Curcumin binds to and results in decreased activity of CBR1 protein; Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; Curcumin inhibits the reaction [NADP metabolite binds to and results in increased activity of CBR1 protein] CTD PMID:25541467 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 increases expression ISO Curcumin results in increased expression of CCAR1 protein CTD PMID:21594647 NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
JBrowse link
G Ccdc116 coiled-coil domain containing 116 increases expression ISO Curcumin results in increased expression of CCDC116 mRNA CTD PMID:18200517 NCBI chr11:83,842,707...83,850,607
Ensembl chr11:83,845,557...83,850,607
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
increases expression
ISO
EXP
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]
Curcumin results in decreased expression of CCL2 mRNA; Curcumin results in decreased expression of CCL2 protein
Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]
Curcumin results in increased expression of CCL2 mRNA
CTD PMID:10925121 PMID:11053056 PMID:17198877 PMID:17666914 PMID:18403477 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of CCN2 mRNA; Curcumin results in decreased expression of CCN2 protein
IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; Lipopolysaccharides inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA]
CTD PMID:17965732 PMID:19764552 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of CCNA2 protein]
Curcumin results in decreased expression of CCNA2 protein
CTD PMID:23222814 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Curcumin results in decreased expression of CCNB1 mRNA; Curcumin results in decreased expression of CCNB1 protein CTD PMID:17148446 PMID:18719366 PMID:19401701 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
decreases expression
increases degradation
ISO
EXP
[Curcumin co-treated with Isoflavones] results in decreased expression of CCND1 protein; calyculin A inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]
Curcumin results in increased expression of CCND1 mRNA
Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of CCND1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CCND1 mRNA]
Curcumin results in decreased expression of CCND1; Curcumin results in decreased expression of CCND1 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of CCND1 protein
Curcumin analog results in decreased expression of CCND1 protein; Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein
CTD PMID:15486348 PMID:15489888 PMID:15738001 PMID:16023083 PMID:16219905 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of CCND3 protein]
Curcumin results in decreased expression of CCND3 protein
CTD PMID:23222814 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 decreases expression
multiple interactions
increases degradation
ISO
EXP
Curcumin results in decreased expression of CCNE1 protein
Curcumin results in decreased expression of CCNE1 mRNA
lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein]
CTD PMID:17148446 PMID:18156803 PMID:18299980 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccpg1 cell cycle progression 1 increases expression ISO Curcumin results in increased expression of CCPG1 mRNA CTD PMID:17198877 NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression ISO Curcumin results in decreased expression of CCR2 mRNA CTD PMID:18403477 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO Curcumin inhibits the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased expression of CD14 protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein] CTD PMID:18180316 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd36 CD36 molecule decreases expression
increases expression
multiple interactions
ISO Curcumin results in decreased expression of CD36 mRNA
Curcumin results in increased expression of CD36 mRNA
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein]
Curcumin results in decreased expression of CD36 mRNA; Curcumin results in decreased expression of CD36 protein
CTD PMID:16713233 PMID:23386263 PMID:23603106 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd40 CD40 molecule decreases expression
multiple interactions
ISO Curcumin results in decreased expression of CD40 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40 protein
CTD PMID:16101141 PMID:27430728 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd40lg CD40 ligand multiple interactions ISO [arsenic trioxide co-treated with Curcumin] results in increased expression of CD40LG protein CTD PMID:27430728 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Curcumin results in increased expression of CD44 mRNA CTD PMID:15713895 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cd47 Cd47 molecule multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA] CTD PMID:18200517 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) decreases expression ISO Curcumin results in decreased expression of CD55 mRNA CTD PMID:17999991 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link
G Cdc14b cell division cycle 14B increases expression ISO Curcumin results in increased expression of CDC14B mRNA CTD PMID:17198877 NCBI chr17:844,731...934,787
Ensembl chr17:844,685...933,235
JBrowse link
G Cdc20 cell division cycle 20 decreases expression ISO Curcumin results in decreased expression of CDC20 mRNA CTD PMID:22258452 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc25c cell division cycle 25C increases phosphorylation ISO Curcumin results in increased phosphorylation of CDC25C protein CTD PMID:19401701 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
ISO Curcumin results in increased expression of CDH1 protein
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]
CTD PMID:19573523 PMID:25656647 PMID:26191140 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh11 cadherin 11 decreases expression ISO Curcumin results in decreased expression of CDH11 protein CTD PMID:18025290 NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
JBrowse link
G Cdh17 cadherin 17 decreases expression ISO Curcumin results in decreased expression of CDH17 mRNA CTD PMID:17198877 NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein] CTD PMID:26191140 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression EXP
ISO
Curcumin results in decreased expression of CDK1 mRNA
Curcumin results in decreased expression of CDK1 mRNA; Curcumin results in decreased expression of CDK1 protein
CTD PMID:17148446 PMID:18299980 PMID:19401701 PMID:22258452 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of CDK2 protein]
Curcumin results in decreased expression of CDK2 protein
Curcumin analog results in decreased expression of CDK2 mRNA; Curcumin results in decreased expression of CDK2 protein
CTD PMID:19501152 PMID:23222814 PMID:26409325 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Curcumin analog results in decreased expression of CDK4 mRNA; Curcumin results in decreased expression of CDK4 protein CTD PMID:18156803 PMID:24211270 PMID:26409325 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk5 cyclin-dependent kinase 5 decreases expression ISO Curcumin analog results in decreased expression of CDK5 mRNA CTD PMID:26409325 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Curcumin results in decreased expression of CDK6 protein CTD PMID:18156803 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdk7 cyclin-dependent kinase 7 decreases expression ISO Curcumin analog results in decreased expression of CDK7 mRNA CTD PMID:26409325 NCBI chr 2:31,840,545...31,865,447
Ensembl chr 2:31,840,558...31,865,383
JBrowse link
G Cdk9 cyclin-dependent kinase 9 decreases expression ISO Curcumin analog results in decreased expression of CDK9 mRNA CTD PMID:26409325 NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
decreases expression
ISO
EXP
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1A protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [piperine co-treated with Curcumin] results in decreased expression of CDKN1A protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CDKN1A protein]
Curcumin results in increased expression of CDKN1A; Curcumin results in increased expression of CDKN1A mRNA; Curcumin results in increased expression of CDKN1A protein
[Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of CDKN1A protein
Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1A protein]
CTD PMID:15713895 PMID:15738001 PMID:17148446 PMID:17332326 PMID:17602960 More... NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
decreases expression
ISO
EXP
Curcumin results in increased expression of CDKN1B mRNA; Curcumin results in increased expression of CDKN1B protein
Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein]
[arsenic trioxide co-treated with Curcumin] results in increased expression of CDKN1B protein; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein]
Curcumin results in decreased expression of CDKN1B protein
CTD PMID:15713895 PMID:17602960 PMID:18156803 PMID:18226269 PMID:18593936 More... NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression
increases expression
ISO Curcumin results in decreased expression of CDKN2A protein
Curcumin results in increased expression of CDKN2A protein
CTD PMID:17148446 PMID:18156803 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D decreases expression EXP Curcumin results in decreased expression of CDKN2D mRNA CTD PMID:18299980 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
JBrowse link
G Cdx2 caudal type homeo box 2 increases expression EXP
ISO
Curcumin results in increased expression of CDX2 mRNA CTD PMID:18299980 PMID:27237783 NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of CEBPA mRNA] CTD PMID:19297423 PMID:28595985 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CEBPB mRNA] CTD PMID:18200517 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA] CTD PMID:18200517 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Ces3a carboxylesterase 3a multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES3 mRNA] CTD PMID:18200517 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]
Curcumin results in decreased expression of CFLAR protein
CTD PMID:16173963 PMID:16219905 PMID:23452621 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
affects localization
ISO [PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Curcumin analog inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid]
Curcumin results in increased activity of CFTR protein; Curcumin results in increased activity of CFTR protein mutant form
Curcumin affects the localization of CFTR protein mutant form
Curcumin affects the folding of and affects the localization of CFTR protein mutant form
CTD PMID:15105504 PMID:15280357 PMID:15582996 PMID:17178710 PMID:23978416 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Chat choline O-acetyltransferase multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHAT protein] CTD PMID:21839772 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Chek1 checkpoint kinase 1 decreases response to substance
increases activity
increases phosphorylation
ISO CHEK1 protein results in decreased susceptibility to Curcumin
Curcumin results in increased activity of CHEK1 protein
Curcumin results in increased phosphorylation of CHEK1 protein
CTD PMID:18602917 PMID:19401701 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation
ISO [Curcumin co-treated with Dihydrotestosterone] results in increased phosphorylation of CHEK2 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of CHEK2 protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein; Flutamide inhibits the reaction [[Dihydrotestosterone co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein]
Curcumin results in increased phosphorylation of CHEK2 protein
CTD PMID:21134073 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHRM2 mRNA] CTD PMID:24952339 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions
decreases activity
ISO Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]
Curcumin results in decreased activity of CHUK protein
CTD PMID:15129424 PMID:15489888 PMID:16023083 PMID:16219905 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Ckb creatine kinase B multiple interactions EXP Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:21378372 PMID:29315967 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:21378372 PMID:29315967 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Clcn6 chloride voltage-gated channel 6 decreases expression ISO Curcumin results in decreased expression of CLCN6 mRNA CTD PMID:17198877 NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059
JBrowse link
G Cldn2 claudin 2 multiple interactions EXP Curcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2] CTD PMID:25119790 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
EXP
ISO
Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]
Curcumin analog inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]
Curcumin results in decreased expression of COL1A1 mRNA; Curcumin results in decreased expression of COL1A1 protein
CTD PMID:17355460 PMID:17434272 PMID:17531121 PMID:17602960 PMID:17965732 More... NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A2 mRNA] CTD PMID:18200517 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col27a1 collagen type XXVII alpha 1 chain increases expression EXP Curcumin results in increased expression of COL27A1 mRNA CTD PMID:18299980 NCBI chr 5:76,647,302...76,765,987
Ensembl chr 5:76,647,429...76,765,174
JBrowse link
G Col2a1 collagen type II alpha 1 chain increases expression
multiple interactions
ISO Curcumin results in increased expression of COL2A1 mRNA; Curcumin results in increased expression of COL2A1 protein
[resveratrol co-treated with Curcumin] results in increased expression of COL2A1 protein
CTD PMID:18321735 PMID:19889203 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA] CTD PMID:22683883 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Col4a1 collagen type IV alpha 1 chain increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of COL4A1 mRNA
Curcumin analog inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A1 mRNA]
CTD PMID:18200517 PMID:21594647 PMID:28700904 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
JBrowse link
G Col4a2 collagen type IV alpha 2 chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A2 mRNA] CTD PMID:18200517 NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
JBrowse link
G Col4a5 collagen type IV alpha 5 chain decreases expression ISO Curcumin results in decreased expression of COL4A5 mRNA CTD PMID:15713895 NCBI chr  X:105,118,762...105,322,699
Ensembl chr  X:105,118,820...105,322,692
JBrowse link
G Col5a1 collagen type V alpha 1 chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A1 mRNA] CTD PMID:18200517 NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588
JBrowse link
G Col5a2 collagen type V alpha 2 chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A2 mRNA] CTD PMID:18200517 NCBI chr 9:47,448,736...47,598,396
Ensembl chr 9:47,448,736...47,598,154
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO Curcumin results in increased expression of CPT1A mRNA CTD PMID:19297423 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions
increases phosphorylation
EXP
ISO
Curcumin results in increased expression of CREB1 mRNA
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CREB1 mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CREB1 protein]
Curcumin results in increased phosphorylation of CREB1 protein
CTD PMID:17022948 PMID:18299980 PMID:22911773 PMID:27966075 PMID:29723552 More... NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Creb3 cAMP responsive element binding protein 3 increases expression EXP Curcumin results in increased expression of CREB3 mRNA CTD PMID:18299980 NCBI chr 5:57,817,835...57,823,171
Ensembl chr 5:57,817,832...57,824,390
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]] CTD PMID:22258452 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Crp C-reactive protein multiple interactions EXP
ISO
Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Curcumin inhibits the reaction [lead acetate results in increased secretion of CRP protein]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of CRP protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of CRP protein]
CTD PMID:21378372 PMID:26713546 PMID:30431687 PMID:31820278 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO
EXP
Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein]
[Curcumin co-treated with arsenite] results in increased expression of CRYAB mRNA; [Curcumin co-treated with Cadmium Chloride] results in increased expression of CRYAB protein; Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein]
CTD PMID:9764755 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Cs citrate synthase affects expression EXP Curcumin affects the expression of CS mRNA CTD PMID:18539377 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein] CTD PMID:15129424 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions
increases expression
ISO Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein]
Curcumin results in increased expression of CSF1R mRNA
CTD PMID:15129424 PMID:22714040 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Csf2ra colony stimulating factor 2 receptor subunit alpha increases expression ISO Curcumin results in increased expression of CSF2RA mRNA CTD PMID:22714040 NCBI chr14:98,089...103,261
Ensembl chr14:89,172...103,128
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CSF2RB mRNA] CTD PMID:18200517 NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
increases expression
multiple interactions
decreases phosphorylation
increases degradation
ISO
EXP
Curcumin analog results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 protein
Curcumin results in increased expression of CTNNB1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of CTNNB1 mRNA]; Curcumin results in decreased phosphorylation of and affects the localization of CTNNB1 protein
Curcumin results in decreased phosphorylation of CTNNB1 protein
[piperine co-treated with Curcumin] results in decreased expression of CTNNB1 protein; Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CTNNB1 protein]
Curcumin analog results in increased degradation of CTNNB1 protein; Curcumin results in increased degradation of CTNNB1 protein
CTD PMID:10783313 PMID:17041101 PMID:19294764 PMID:19573523 PMID:25963729 More... NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsb cathepsin B multiple interactions
decreases expression
EXP
ISO
Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]
Curcumin analog results in decreased expression of CTSB mRNA
CTD PMID:8534267 PMID:26409325 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsd cathepsin D multiple interactions
decreases expression
EXP
ISO
Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]
Curcumin analog results in decreased expression of CTSD mRNA
CTD PMID:8534267 PMID:26409325 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctss cathepsin S decreases expression ISO Curcumin results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
decreases expression
ISO NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]
Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein
CTD PMID:17999991 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein] CTD PMID:18660423 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO Curcumin results in decreased expression of CXCL14 mRNA CTD PMID:19555370 NCBI chr17:8,317,933...8,325,956
Ensembl chr17:8,317,933...8,324,839
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of CXCL2 mRNA; Curcumin results in decreased expression of CXCL2 protein
Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CXCL2 mRNA]
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA]
CTD PMID:17999991 PMID:18001810 PMID:18200517 PMID:27194111 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein
Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 mRNA]; Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 protein]
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]
CTD PMID:17999991 PMID:27194111 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression ISO Curcumin results in increased expression of CXCR1 protein CTD PMID:12216086 NCBI chr 9:75,768,124...75,771,122
Ensembl chr 9:75,766,770...75,771,084
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression ISO Curcumin results in increased expression of CXCR2 protein CTD PMID:12216086 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of CXCR4 mRNA
Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]
CTD PMID:17198877 PMID:18660423 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO Curcumin affects the localization of CYCS protein
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CYCS protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased expression of CYCS protein
CTD PMID:19235267 PMID:27430728 PMID:33617879 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression
decreases activity
decreases expression
ISO
EXP
Acetylcysteine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Curcumin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; decitabine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; trichostatin A affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A1 protein]
Curcumin results in increased activity of CYP1A1 protein
Curcumin results in increased expression of CYP1A1 mRNA
Curcumin results in decreased activity of CYP1A1 protein
Curcumin results in decreased expression of CYP1A1 mRNA
Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:11454723 PMID:12628514 PMID:15841493 PMID:16288784 PMID:17012224 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
multiple interactions
ISO
EXP
Curcumin results in decreased activity of CYP1A2 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A2 protein]
Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]
CTD PMID:15841493 PMID:16288784 PMID:18321868 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]
Curcumin results in decreased expression of CYP1B1 mRNA
CTD PMID:17637178 PMID:19018768 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA
Curcumin results in increased expression of CYP24A1 protein
CTD PMID:20153625 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression
multiple interactions
EXP Curcumin affects the expression of CYP2B1 protein
Curcumin inhibits the reaction [CYP2B1 protein results in increased metabolism of nitrosobenzylmethylamine]
CTD PMID:16805852 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 multiple interactions EXP Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2C9 protein] CTD PMID:16288784 NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases expression ISO Curcumin results in decreased expression of CYP2D6 mRNA CTD PMID:33582110 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects expression
multiple interactions
increases expression
EXP
ISO
Curcumin affects the expression of CYP2E1 protein
Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]
Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite promotes the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]
Curcumin inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein]
Curcumin results in increased expression of CYP2E1 mRNA
CTD PMID:16805852 PMID:18539377 PMID:24508477 PMID:30423402 PMID:33350580 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
multiple interactions
increases expression
ISO Curcumin results in decreased expression of CYP3A4 mRNA
[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; Curcumin inhibits the reaction [Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein]; Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Curcumin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]
Curcumin results in increased expression of CYP3A4 mRNA
CTD PMID:17210444 PMID:17270371 PMID:17965521 PMID:18385293 PMID:20153625 More... NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP Curcumin results in increased expression of CYP4A3 mRNA CTD PMID:18539377 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
JBrowse link
G Cyth4 cytohesin 4 increases expression ISO Curcumin results in increased expression of CYTH4 mRNA CTD PMID:17198877 NCBI chr 7:110,152,232...110,176,741
Ensembl chr 7:110,152,272...110,176,741
JBrowse link
G Daxx death-domain associated protein increases expression ISO Curcumin results in increased expression of DAXX mRNA CTD PMID:16101141 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
JBrowse link
G Dbn1 drebrin 1 multiple interactions EXP Curcumin inhibits the reaction [Glucose results in decreased expression of DBN1 mRNA] CTD PMID:23333261 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984
JBrowse link
G Dcn decorin increases expression ISO Curcumin results in increased expression of DCN mRNA CTD PMID:21594647 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Dcx doublecortin multiple interactions
increases expression
EXP
ISO
Curcumin inhibits the reaction [bisphenol A results in decreased expression of DCX mRNA]
Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of DCX protein]
Curcumin results in increased expression of DCX mRNA
CTD PMID:25963729 PMID:32735850 NCBI chr  X:107,430,767...107,573,612
Ensembl chr  X:107,430,767...107,507,476
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]
Curcumin results in increased expression of DDIT3 mRNA; Curcumin results in increased expression of DDIT3 protein
CTD PMID:16613838 PMID:17171638 PMID:18200517 PMID:18719366 PMID:21793155 More... NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like decreases expression
increases expression
ISO
EXP
Curcumin results in decreased expression of DDIT4L mRNA
Curcumin results in increased expression of DDIT4L mRNA
CTD PMID:17999991 PMID:18299980 NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
JBrowse link
G Dffb DNA fragmentation factor subunit beta increases expression
decreases expression
ISO Curcumin results in increased expression of DFFB mRNA; Curcumin results in increased expression of DFFB protein
Curcumin results in decreased expression of DFFB protein
CTD PMID:21397623 PMID:22714040 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression
affects expression
EXP
ISO
Curcumin results in decreased expression of DHCR24 mRNA
Curcumin affects the expression of DHCR24 mRNA
CTD PMID:27208389 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase affects expression
decreases expression
ISO
EXP
Curcumin affects the expression of DHCR7 mRNA
Curcumin results in decreased expression of DHCR7 mRNA
CTD PMID:27208389 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
JBrowse link
G Dhrs1 dehydrogenase/reductase 1 decreases expression ISO Curcumin results in decreased expression of DHRS1 mRNA CTD PMID:17198877 NCBI chr15:29,236,522...29,243,807
Ensembl chr15:29,236,522...29,243,838
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein affects localization
multiple interactions
increases expression
increases response to substance
ISO Curcumin affects the localization of DIABLO protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of DIABLO protein
Curcumin results in increased expression of DIABLO mRNA
DIABLO protein results in increased susceptibility to Curcumin
CTD PMID:17277231 PMID:23555722 PMID:27430728 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 decreases expression
multiple interactions
EXP Curcumin results in decreased expression of DKK1 mRNA; Curcumin results in decreased expression of DKK1 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 protein]
CTD PMID:25963729 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DLG4 protein] CTD PMID:29723552 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Curcumin results in increased expression of DNAJB9 mRNA CTD PMID:17999991 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP Curcumin inhibits the reaction [Potassium Dichromate results in increased expression of DNM1L protein] CTD PMID:32980475 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression
affects expression
multiple interactions
increases activity
ISO Curcumin results in decreased expression of DNMT1 mRNA; Curcumin results in decreased expression of DNMT1 protein
Curcumin analog affects the expression of DNMT1 protein
Curcumin promotes the reaction [Quercetin results in increased activity of DNMT1 protein]; Quercetin promotes the reaction [Curcumin results in increased activity of DNMT1 protein]
Curcumin analog results in decreased expression of DNMT1 protein
CTD PMID:23593078 PMID:26991801 PMID:27132804 PMID:29228771 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO Curcumin results in decreased expression of DNMT3A mRNA
Curcumin analog results in decreased expression of DNMT3A protein
CTD PMID:23593078 PMID:26991801 PMID:29228771 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO Curcumin results in decreased expression of DNMT3B mRNA
Curcumin analog results in decreased expression of DNMT3B protein
CTD PMID:23593078 PMID:26991801 PMID:29228771 NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Dram1 DNA-damage regulated autophagy modulator 1 increases expression ISO Curcumin results in increased expression of DRAM1 mRNA CTD PMID:21594647 NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DRD2 protein] CTD PMID:27966075 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of DUSP1 mRNA
Curcumin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of DUSP1 protein]
CTD PMID:15713895 PMID:20885979 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO Curcumin results in increased expression of DUSP10 mRNA CTD PMID:15713895 PMID:17151092 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO Curcumin results in increased expression of DUSP5 mRNA CTD PMID:17198877 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Dvl1 dishevelled segment polarity protein 1 multiple interactions
decreases expression
increases expression
EXP
ISO
Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 protein]
Curcumin results in decreased expression of DVL1 protein
Curcumin results in increased expression of DVL1 mRNA; Curcumin results in increased expression of DVL1 protein
CTD PMID:19573523 PMID:25963729 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
JBrowse link
G Dynll1 dynein light chain LC8-type 1 increases expression ISO Curcumin results in increased expression of DYNLL1 mRNA CTD PMID:17198877 NCBI chr12:41,312,367...41,314,742
Ensembl chr12:41,312,367...41,314,741
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 decreases activity
multiple interactions
ISO Curcumin results in decreased activity of DYRK2 protein
[Curcumin binds to 4-nitrobenzaldehyde] which results in decreased activity of DYRK2 protein
CTD PMID:33617879 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression EXP Curcumin results in decreased expression of E2F1 mRNA CTD PMID:18299980 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G E2f5 E2F transcription factor 5 decreases expression ISO Curcumin results in decreased expression of E2F5 mRNA CTD PMID:15713895 NCBI chr 2:86,997,331...87,012,901
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP Curcumin results in increased expression of ECH1 mRNA CTD PMID:18539377 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Edaradd EDAR-associated death domain multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA] CTD PMID:23452621 NCBI chr17:85,866,629...85,910,612
Ensembl chr17:85,656,905...85,910,447
JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 decreases expression ISO Curcumin results in decreased expression of EDIL3 mRNA CTD PMID:18421014 NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
JBrowse link
G Egf epidermal growth factor multiple interactions
decreases activity
ISO
EXP
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein]
Curcumin results in decreased activity of EGF protein
Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]
CTD PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:18214481 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases phosphorylation
decreases expression
ISO
EXP
Curcumin inhibits the reaction [Acrylamide results in increased expression of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of EGFR protein]; Curcumin results in decreased expression of and results in decreased activity of EGFR protein; Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of EGFR protein]; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein]
Curcumin results in decreased phosphorylation of EGFR protein
Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]
Curcumin analog results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein
CTD PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:17918158 More... NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
decreases expression
ISO
EXP
EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of EGR1 protein]; U 0126 inhibits the reaction [Curcumin results in increased expression of EGR1 protein]
Curcumin results in increased expression of EGR1 mRNA; Curcumin results in increased expression of EGR1 protein
Curcumin results in decreased expression of EGR1 mRNA
CTD PMID:17198877 PMID:17999991 PMID:18316600 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 decreases expression ISO Curcumin results in decreased expression of EIF1 mRNA CTD PMID:17999991 NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases expression
decreases phosphorylation
ISO calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of EIF4EBP1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of EIF4EBP1 protein]
Curcumin results in decreased expression of EIF4EBP1 protein
CTD PMID:18790744 PMID:23222814 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma, 1 decreases phosphorylation ISO Curcumin results in decreased phosphorylation of EIF4G1 protein CTD PMID:18790744 NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941
JBrowse link
G Elf2 E74 like ETS transcription factor 2 decreases expression ISO Curcumin results in decreased expression of ELF2 mRNA CTD PMID:15713895 NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions
increases phosphorylation
ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ELK1 mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein] CTD PMID:18316600 PMID:23452621 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Emb embigin multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of EMB mRNA] CTD PMID:18200517 NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050
JBrowse link
G Eno1 enolase 1 decreases expression ISO Curcumin results in decreased expression of ENO1 mRNA CTD PMID:16880289 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 increases expression EXP Curcumin results in increased expression of ENTPD5 mRNA CTD PMID:18299980 NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions
decreases activity
decreases expression
affects localization
ISO
EXP
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]]
Curcumin results in decreased activity of EP300 protein
Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein]
Curcumin results in decreased expression of EP300 mRNA; Curcumin results in decreased expression of EP300 protein
CTD PMID:17927689 PMID:22228707 PMID:22258452 PMID:26612707 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions ISO Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:20554536 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions
decreases expression
ISO WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM protein]
Curcumin results in decreased expression of EPCAM mRNA; Curcumin results in decreased expression of EPCAM protein
CTD PMID:33539684 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Epo erythropoietin decreases expression ISO Curcumin results in decreased expression of EPO mRNA CTD PMID:16880289 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
increases response to substance
increases degradation
decreases expression
ISO [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Doxorubicin]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Etoposide]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog promotes the reaction [Cycloheximide results in increased degradation of ERBB2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased expression of and results in decreased activity of ERBB2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein
Curcumin analog results in increased degradation of ERBB2 protein
Curcumin analog results in decreased expression of ERBB2 mRNA; Curcumin analog results in decreased expression of ERBB2 protein; Curcumin results in decreased expression of ERBB2 mRNA; Curcumin results in decreased expression of ERBB2 protein
CTD PMID:17041101 PMID:17918158 PMID:18719366 PMID:25866362 PMID:26409325 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions
decreases expression
ISO Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]
Curcumin analog results in decreased expression of ERBB3 mRNA; Curcumin results in decreased expression of ERBB3 mRNA
CTD PMID:15713895 PMID:17918158 PMID:26409325 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions
decreases expression
ISO
EXP
[Curcumin results in decreased expression of ERCC1 protein] which results in increased susceptibility to Cisplatin; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 protein]
Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA]
Curcumin results in decreased expression of ERCC1 mRNA; Curcumin results in decreased expression of ERCC1 protein
CTD PMID:17596214 PMID:21493726 PMID:22228707 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit multiple interactions
decreases expression
EXP
ISO
Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC4 mRNA]
Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 protein]
Curcumin results in decreased expression of ERCC4 mRNA; Curcumin results in decreased expression of ERCC4 protein
CTD PMID:22228707 NCBI chr10:2,416,259...2,448,364 JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 decreases expression
increases expression
ISO Curcumin results in decreased expression of ERN1 mRNA
Curcumin results in increased expression of ERN1 mRNA
CTD PMID:17999991 PMID:29723631 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased degradation of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; Curcumin inhibits the reaction [fulvestrant results in increased degradation of ESR1 protein]
Curcumin results in decreased expression of ESR1 protein
CTD PMID:15899841 PMID:18347134 PMID:23222814 PMID:24211270 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor decreases expression ISO Curcumin results in decreased expression of ETS2 protein CTD PMID:17332326 NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
JBrowse link
G F2 coagulation factor II multiple interactions EXP Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein] CTD PMID:18565277 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA] CTD PMID:23452621 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA] CTD PMID:18983524 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA] CTD PMID:23452621 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fads1 fatty acid desaturase 1 affects expression
decreases expression
ISO
EXP
Curcumin affects the expression of FADS1 mRNA
Curcumin results in decreased expression of FADS1 mRNA
CTD PMID:27208389 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression
affects expression
EXP
ISO
Curcumin results in decreased expression of FADS2 mRNA
Curcumin affects the expression of FADS2 mRNA
CTD PMID:27208389 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
JBrowse link
G Fam120b family with sequence similarity 120B decreases expression ISO Curcumin results in decreased expression of FAM120B mRNA CTD PMID:17999991 NCBI chr 1:56,320,015...56,385,064
Ensembl chr 1:56,339,129...56,385,061
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]
Curcumin results in decreased expression of FANCD2 mRNA
CTD PMID:24124520 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Fanci FA complementation group I multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]
Curcumin results in decreased expression of FANCI mRNA
CTD PMID:24124520 NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [arsenic trioxide co-treated with Curcumin] results in increased expression of FAS protein CTD PMID:27430728 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions
decreases expression
ISO
EXP
[arsenic trioxide co-treated with Curcumin] results in increased expression of FASLG protein; Curcumin inhibits the reaction [[vorinostat co-treated with Bortezomib] results in increased expression of FASLG protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FASLG mRNA]
Curcumin results in decreased expression of FASLG mRNA
CTD PMID:10925121 PMID:16101141 PMID:17351739 PMID:23452621 PMID:27430728 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase affects expression
decreases expression
ISO
EXP
Curcumin affects the expression of FASN mRNA; Curcumin affects the expression of FASN protein
Curcumin results in decreased expression of FASN mRNA
CTD PMID:27208389 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fbln2 fibulin 2 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FBLN2 mRNA] CTD PMID:18200517 NCBI chr 4:123,704,289...123,763,857
Ensembl chr 4:123,704,373...123,763,948
JBrowse link
G Fcgr3a Fc gamma receptor IIIa multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FCGR3A mRNA] CTD PMID:18200517 NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression EXP Curcumin results in decreased expression of FDFT1 mRNA CTD PMID:27208389 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression
decreases expression
affects expression
ISO
EXP
Curcumin results in increased expression of FDPS mRNA
Curcumin results in decreased expression of FDPS mRNA
Curcumin affects the expression of FDPS mRNA
CTD PMID:16713233 PMID:27208389 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression
increases expression
ISO Curcumin results in decreased expression of FGF2 protein
Curcumin results in increased expression of FGF2 protein
CTD PMID:23555722 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgf5 fibroblast growth factor 5 decreases expression ISO Curcumin results in decreased expression of FGF5 mRNA CTD PMID:27237783 NCBI chr14:11,325,334...11,346,570
Ensembl chr14:11,325,334...11,345,997
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO Curcumin results in decreased expression of FGFR2 mRNA CTD PMID:15713895 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Filip1l filamin A interacting protein 1-like increases expression ISO Curcumin results in increased expression of FILIP1L mRNA CTD PMID:21594647 NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions EXP Curcumin inhibits the reaction [Cisplatin results in increased expression of FIS1 protein] CTD PMID:28698153 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions
decreases expression
EXP
ISO
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of FLT1 protein]
Curcumin results in decreased expression of FLT1 protein
CTD PMID:18593936 PMID:23845850 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
ISO
EXP
Curcumin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of FN1 protein]
Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]
Curcumin results in decreased expression of FN1 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FN1 mRNA]
CTD PMID:12388107 PMID:18200517 PMID:18555241 PMID:21998146 PMID:22228707 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fntb farnesyltransferase, CAAX box, beta increases expression ISO Curcumin results in increased expression of FNTB mRNA CTD PMID:17999991 NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
increases expression
ISO
EXP
Curcumin results in decreased expression of FOS mRNA
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of FOS protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FOS mRNA]
Curcumin results in increased expression of FOS mRNA
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
CTD PMID:15713895 PMID:17827730 PMID:17999991 PMID:23452621 PMID:26191140 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions
increases ubiquitination
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]
Curcumin results in increased ubiquitination of FOSL1 protein
CTD PMID:17148446 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO Curcumin results in decreased expression of FOSL2 mRNA
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL2 protein]
CTD PMID:17148446 PMID:17999991 NCBI chr 6:24,297,898...24,319,157
Ensembl chr 6:24,300,956...24,320,034
JBrowse link
G Foxa1 forkhead box A1 multiple interactions ISO Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]] CTD PMID:22258452 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
JBrowse link
G Foxa2 forkhead box A2 decreases expression ISO Curcumin results in decreased expression of FOXA2 mRNA CTD PMID:27237783 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
JBrowse link
G Foxf2 forkhead box F2 decreases expression ISO Curcumin results in decreased expression of FOXF2 mRNA CTD PMID:15713895 NCBI chr17:32,835,730...32,842,555 JBrowse link
G Foxo1 forkhead box O1 increases expression
decreases phosphorylation
ISO Curcumin results in increased expression of FOXO1 mRNA
Curcumin results in decreased phosphorylation of FOXO1 protein
CTD PMID:18403477 PMID:18790744 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Fpr3 formyl peptide receptor 3 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FPR3 mRNA] CTD PMID:18200517 NCBI chr 1:58,884,400...58,893,475
Ensembl chr 1:58,845,118...58,893,467
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein] CTD PMID:31199764 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Fstl1 follistatin-like 1 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNA] CTD PMID:18200517 NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
JBrowse link
G Ftl1 ferritin light chain 1 decreases expression ISO Curcumin results in decreased expression of FTL1 mRNA CTD PMID:24634837 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G Fus FUS RNA binding protein increases expression
decreases expression
ISO Curcumin results in increased expression of FUS mRNA
Curcumin results in decreased expression of FUS mRNA
CTD PMID:17198877 PMID:17999991 NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414
JBrowse link
G Fzd1 frizzled class receptor 1 decreases expression ISO Curcumin results in decreased expression of FZD1 mRNA CTD PMID:15713895 NCBI chr 4:29,310,303...29,314,701 JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 affects expression ISO Curcumin affects the expression of G6PC mRNA CTD PMID:27208389 NCBI chr10:86,307,400...86,318,766 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression EXP Curcumin results in increased expression of G6PD mRNA; Curcumin results in increased expression of G6PDX mRNA CTD PMID:18299980 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression EXP Curcumin results in decreased expression of GABRA1 mRNA CTD PMID:18299980 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP Curcumin inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA] CTD PMID:23267840 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP
ISO
Curcumin results in increased expression of GADD45A mRNA CTD PMID:16101141 PMID:18299980 PMID:18719366 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gas6 growth arrest specific 6 increases expression ISO Curcumin results in increased expression of GAS6 mRNA CTD PMID:21594647 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions ISO Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA] CTD PMID:22258452 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G