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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbapenems
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Accession:CHEBI:46633 term browser browse the term
Definition:The class of beta-lactam antibiotics that whose members have a carbapenem skeleton which is variously substituted at positions 3, 4, and 6.
Synonyms:related_synonym: Formula=C7H4NO3R3;   SMILES=[H][C@@]12C([*])C(=O)N1C(C(O)=O)=C([*])C2[*]
 xref_mesh: MESH:D015780
 xref: PMID:18076336;   PMID:19199922;   PMID:19610642;   PMID:19617229;   PMID:19929840;   PMID:21859938;   Wikipedia:Carbapenem


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carbapenems term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apeh acylaminoacyl-peptide hydrolase multiple interactions
decreases activity
ISO Carbapenems inhibits the reaction [APEH protein results in increased metabolism of valproic acid glucuronide]
Carbapenems results in decreased activity of APEH protein
CTD PMID:20551238 NCBI chr 8:116,862,664...116,871,776
Ensembl chr 8:116,862,625...116,872,215
JBrowse link
imipenem hydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of ABCB11 mRNA CTD PMID:24657338 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of ABCB1A mRNA CTD PMID:24657338 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Vancomycin co-treated with Imipenem] affects the expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of ABCC3 mRNA CTD PMID:24657338 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions ISO [Vancomycin co-treated with Imipenem] affects the expression of ABCG5 mRNA CTD PMID:24657338 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 multiple interactions ISO [Vancomycin co-treated with Imipenem] affects the expression of ABCG8 mRNA CTD PMID:24657338 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of BAAT mRNA CTD PMID:24657338 NCBI chr 5:64,768,397...64,777,368
Ensembl chr 5:64,768,401...64,777,368
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of CYP7A1 mRNA CTD PMID:24657338 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of CYP8B1 mRNA CTD PMID:24657338 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of NPC1L1 mRNA CTD PMID:24657338 NCBI chr14:86,345,946...86,560,694
Ensembl chr14:86,345,953...86,560,694
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of NR0B2 mRNA CTD PMID:24657338 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Imipenem results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of NR5A2 mRNA CTD PMID:24657338 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of SLC10A1 mRNA CTD PMID:24657338 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc27a5 solute carrier family 27 member 5 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of SLC27A5 mRNA CTD PMID:24657338 NCBI chr 1:65,576,599...65,587,192
Ensembl chr 1:65,576,535...65,587,186
JBrowse link
G Slc51a solute carrier family 51 subunit alpha multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of SLC51A mRNA CTD PMID:24657338 NCBI chr11:71,533,078...71,547,476
Ensembl chr11:71,533,078...71,547,476
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of SLCO1A4 mRNA CTD PMID:24657338 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of SLCO1B2 mRNA CTD PMID:24657338 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of SLCO2B1 mRNA CTD PMID:24657338 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
meropenem term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-DOb RT1 class II, locus DOb affects expression ISO meropenem affects the expression of HLA-DOB mRNA CTD PMID:25811541 NCBI chr20:4,020,273...4,026,398
Ensembl chr20:4,020,317...4,026,346
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          antibacterial agent 13019
            carbapenems 21
              (4R,5S,6R)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 0
              (5R,6R)-3-[2-(aminomethylideneamino)ethylthio]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 0
              1beta-methylcarbapenem 0
              2,3-Dihydrothienamycin 0
              Asparenomycin A 0
              BO 2727 0
              Deacetylepithienamycin F 0
              Doripenem hydrate 0
              Epithienamycin A 0
              Epithienamycin B 0
              Epithienamycin C 0
              Epithienamycin F 0
              MK826 0
              N-Acetylthienamycin 0
              NS-5 0
              Northienamycin 0
              OA-6129 A 0
              OA-6129 B1 0
              OA-6129 B2 0
              OA-6129 D 0
              OA-6129 E 0
              PS-5 0
              PS-6 0
              SM-17466 0
              Thienamycin 0
              biapenem 0
              carbapenem + 0
              carbapenemcarboxylic acid + 1
              doripenem 0
              epithienamycin E 0
              imipenem + 19
              imipenem hydrate 19
              tebipenem pivoxil 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                lactam 8026
                                                  beta-lactam 789
                                                    beta-lactam antibiotic 777
                                                      carbapenems 21
                                                        (4R,5S,6R)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 0
                                                        (5R,6R)-3-[2-(aminomethylideneamino)ethylthio]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 0
                                                        1beta-methylcarbapenem 0
                                                        2,3-Dihydrothienamycin 0
                                                        Asparenomycin A 0
                                                        BO 2727 0
                                                        Deacetylepithienamycin F 0
                                                        Doripenem hydrate 0
                                                        Epithienamycin A 0
                                                        Epithienamycin B 0
                                                        Epithienamycin C 0
                                                        Epithienamycin F 0
                                                        MK826 0
                                                        N-Acetylthienamycin 0
                                                        NS-5 0
                                                        Northienamycin 0
                                                        OA-6129 A 0
                                                        OA-6129 B1 0
                                                        OA-6129 B2 0
                                                        OA-6129 D 0
                                                        OA-6129 E 0
                                                        PS-5 0
                                                        PS-6 0
                                                        SM-17466 0
                                                        Thienamycin 0
                                                        biapenem 0
                                                        carbapenem + 0
                                                        carbapenemcarboxylic acid + 1
                                                        doripenem 0
                                                        epithienamycin E 0
                                                        imipenem + 19
                                                        imipenem hydrate 19
                                                        tebipenem pivoxil 0
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