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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbapenems
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Accession:CHEBI:46633 term browser browse the term
Definition:The class of beta-lactam antibiotics that whose members have a carbapenem skeleton which is variously substituted at positions 3, 4, and 6.
Synonyms:related_synonym: Formula=C7H4NO3R3;   SMILES=[H][C@@]12C([*])C(=O)N1C(C(O)=O)=C([*])C2[*]
 xref_mesh: MESH:D015780
 xref: PMID:18076336;   PMID:19199922;   PMID:19610642;   PMID:19617229;   PMID:19929840;   PMID:21859938;   Wikipedia:Carbapenem



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carbapenems term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apeh acylaminoacyl-peptide hydrolase multiple interactions
decreases activity
ISO Carbapenems inhibits the reaction [APEH protein results in increased metabolism of valproic acid glucuronide]
Carbapenems results in decreased activity of APEH protein
CTD PMID:20551238 NCBI chr 8:108,773,791...108,782,903
Ensembl chr 8:108,773,794...108,782,933
JBrowse link
imipenem hydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of ABCB11 mRNA CTD PMID:24657338 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of ABCB1A mRNA CTD PMID:24657338 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Vancomycin co-treated with Imipenem] affects the expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of ABCC3 mRNA CTD PMID:24657338 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions ISO [Vancomycin co-treated with Imipenem] affects the expression of ABCG5 mRNA CTD PMID:24657338 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 multiple interactions ISO [Vancomycin co-treated with Imipenem] affects the expression of ABCG8 mRNA CTD PMID:24657338 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of BAAT mRNA CTD PMID:24657338 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of CYP7A1 mRNA CTD PMID:24657338 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of CYP8B1 mRNA CTD PMID:24657338 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of NPC1L1 mRNA CTD PMID:24657338 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of NR0B2 mRNA CTD PMID:24657338 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Imipenem results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of NR5A2 mRNA CTD PMID:24657338 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of SLC10A1 mRNA CTD PMID:24657338 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc27a5 solute carrier family 27 member 5 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of SLC27A5 mRNA CTD PMID:24657338 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172
JBrowse link
G Slc51a solute carrier family 51 subunit alpha multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of SLC51A mRNA CTD PMID:24657338 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of SLCO1A4 mRNA CTD PMID:24657338 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of SLCO1B2 mRNA CTD PMID:24657338 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of SLCO2B1 mRNA CTD PMID:24657338 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
meropenem term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-DOb RT1 class II, locus DOb affects expression ISO meropenem affects the expression of HLA-DOB mRNA CTD PMID:25811541 NCBI chr20:4,619,599...4,625,627
Ensembl chr20:4,619,816...4,625,667
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        antimicrobial agent 17482
          antibacterial agent 13982
            carbapenems 21
              (4R,5S,6R)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 0
              (5R,6R)-3-[2-(aminomethylideneamino)ethylthio]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 0
              1beta-methylcarbapenem 0
              2,3-Dihydrothienamycin 0
              Asparenomycin A 0
              BO 2727 0
              Carbapenem biosynthesis intermediate 6 0
              Deacetylepithienamycin F 0
              Doripenem hydrate 0
              Epithienamycin A 0
              Epithienamycin B 0
              Epithienamycin C 0
              Epithienamycin F 0
              MK826 0
              N-Acetylthienamycin 0
              NS-5 0
              Northienamycin 0
              OA-6129 A 0
              OA-6129 B1 0
              OA-6129 B2 0
              OA-6129 C 0
              OA-6129 D 0
              OA-6129 E 0
              PS-5 0
              PS-6 0
              SM-17466 0
              Thienamycin 0
              biapenem 0
              carbapenem + 0
              carbapenemcarboxylic acid + 1
              doripenem 0
              epithienamycin E 0
              imipenem + 19
              imipenem hydrate 19
              tebipenem pivoxil 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        carboacyl group 17490
                                          univalent carboacyl group 17490
                                            carbamoyl group 17304
                                              carboxamide 17304
                                                lactam 8311
                                                  beta-lactam 796
                                                    beta-lactam antibiotic 781
                                                      carbapenems 21
                                                        (4R,5S,6R)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 0
                                                        (5R,6R)-3-[2-(aminomethylideneamino)ethylthio]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 0
                                                        1beta-methylcarbapenem 0
                                                        2,3-Dihydrothienamycin 0
                                                        Asparenomycin A 0
                                                        BO 2727 0
                                                        Carbapenem biosynthesis intermediate 6 0
                                                        Deacetylepithienamycin F 0
                                                        Doripenem hydrate 0
                                                        Epithienamycin A 0
                                                        Epithienamycin B 0
                                                        Epithienamycin C 0
                                                        Epithienamycin F 0
                                                        MK826 0
                                                        N-Acetylthienamycin 0
                                                        NS-5 0
                                                        Northienamycin 0
                                                        OA-6129 A 0
                                                        OA-6129 B1 0
                                                        OA-6129 B2 0
                                                        OA-6129 C 0
                                                        OA-6129 D 0
                                                        OA-6129 E 0
                                                        PS-5 0
                                                        PS-6 0
                                                        SM-17466 0
                                                        Thienamycin 0
                                                        biapenem 0
                                                        carbapenem + 0
                                                        carbapenemcarboxylic acid + 1
                                                        doripenem 0
                                                        epithienamycin E 0
                                                        imipenem + 19
                                                        imipenem hydrate 19
                                                        tebipenem pivoxil 0
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