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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:disopyramide
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Accession:CHEBI:4657 term browser browse the term
Definition:A monocarboxylic acid amide that is butanamide substituted by a diisopropylamino group at position 4, a phenyl group at position 2 and a pyridin-2-yl group at position 2. It is used as a anti-arrhythmia drug.
Synonyms:exact_synonym: 4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide
 related_synonym: Formula=C21H29N3O;   InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25);   InChIKey=UVTNFZQICZKOEM-UHFFFAOYSA-N;   SMILES=CC(C)N(CCC(C(N)=O)(c1ccccc1)c1ccccn1)C(C)C;   alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide;   disopiramida;   disopyramidum;   gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide
 xref: Beilstein:492056;   CAS:3737-09-5;   DrugBank:DB00280;   Drug_Central:926;   KEGG:C06965;   KEGG:D00303;   LINCS:LSM-1439
 xref_mesh: MESH:D004206
 xref: PMID:16842817;   PMID:24502246;   Patent:BE617730;   Patent:US3225054;   Reaxys:492056;   Wikipedia:Disopyramide



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disopyramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 increases expression ISO Disopyramide results in increased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Disopyramide results in increased expression of ASAH1 mRNA CTD PMID:15342952 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing
ISO Clarithromycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Disopyramide] CTD PMID:10234723 PMID:10901704 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
ISO Disopyramide results in decreased activity of KCNH2 protein
Disopyramide binds to and results in decreased activity of KCNH2 protein
CTD PMID:15272206 PMID:18724381 PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO Disopyramide results in decreased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Disopyramide results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions EXP Disopyramide affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:12440152 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions EXP
ISO
Disopyramide affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
Disopyramide inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Disopyramide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD PMID:12440152 PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      application 19546
        pharmaceutical 19425
          drug 19425
            cardiovascular drug 8454
              anti-arrhythmia drug 1493
                disopyramide 8
                  disopyramide phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic acid 18518
                                        carboacyl group 17656
                                          univalent carboacyl group 17656
                                            carbamoyl group 17497
                                              carboxamide 17497
                                                monocarboxylic acid amide 15562
                                                  disopyramide 8
                                                    disopyramide phosphate 0
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