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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dipyridamole
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Accession:CHEBI:4653 term browser browse the term
Definition:A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Synonyms:exact_synonym: 2,2',2'',2'''-[(4,8-dipiperidin-1-ylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol
 related_synonym: Cardoxin;   Cleridium 150;   Curantyl;   Dipyridamine;   Dipyudamine;   Dypyridamol;   Formula=C24H40N8O4;   InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2;   InChIKey=IZEKFCXSFNUWAM-UHFFFAOYSA-N;   Persantin;   SMILES=OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO;   dipiridamol;   dipyridamolum
 xref: Beilstein:0068373;   CAS:58-32-2;   DrugBank:DB00975;   Drug_Central:924;   KEGG:D00302;   LINCS:LSM-3927
 xref_mesh: MESH:D004176
 xref: PMID:11098344;   PMID:11709364;   Patent:GB807826;   Patent:US3031450;   Reaxys:68373;   Wikipedia:Dipyridamole


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dipyridamole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Dipyridamole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Dipyridamole results in decreased activity of ABCB11 protein
CTD PMID:23956101, PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases activity
multiple interactions
ISO Dipyridamole results in decreased activity of ABCC4 protein
Dipyridamole inhibits the reaction [ABCC4 protein results in increased transport of Cyclic GMP]
CTD PMID:11856762, PMID:15827327 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Adora3 adenosine A3 receptor increases expression EXP Dipyridamole results in increased expression of ADORA3 protein CTD PMID:17101059 NCBI chr 2:208,336,909...208,379,217
Ensembl chr 2:208,373,154...208,376,803
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein CTD PMID:19603250 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 protein] CTD PMID:20063052 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp1 caspase 1 increases activity EXP Dipyridamole results in increased activity of CASP1 protein CTD PMID:21832250 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Dipyridamole results in increased activity of CASP3 protein] CTD PMID:17303086, PMID:22700542 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Dipyridamole results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Dipyridamole results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein] CTD PMID:17303086 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP
ISO
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; tin protoporphyrin IX inhibits the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
CTD PMID:16765938, PMID:20940016 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd40lg CD40 ligand decreases secretion ISO Dipyridamole results in decreased secretion of CD40LG protein CTD PMID:16046616 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA alternative form]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR protein] CTD PMID:17303086 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cldn5 claudin 5 increases expression ISO Dipyridamole results in increased expression of CLDN5 mRNA CTD PMID:20711499 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
ISO
EXP
Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]
Dipyridamole results in decreased expression of COL1A1 mRNA
CTD PMID:7617123, PMID:11576339, PMID:12271277 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]] CTD PMID:11576339 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Dipyridamole results in decreased expression of CXCL12 mRNA CTD PMID:20711499 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO mRNA]; Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO protein] CTD PMID:20063052 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases phosphorylation
multiple interactions
ISO
EXP
Dipyridamole results in increased phosphorylation of DUSP1 protein
DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]]; HMOX1 mRNA affects the reaction [Dipyridamole results in increased phosphorylation of DUSP1 protein]
DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
CTD PMID:16765938, PMID:19356721 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression EXP Dipyridamole results in decreased expression of ENPP1 protein CTD PMID:21414308 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Fadd Fas associated via death domain increases expression
multiple interactions
ISO Dipyridamole results in increased expression of FADD mRNA
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of FADD mRNA]
CTD PMID:17303086 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Dipyridamole results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP Dipyridamole results in increased expression of HMOX1 protein
HMOX1 mRNA affects the reaction [Dipyridamole results in increased phosphorylation of DUSP1 protein]
CTD PMID:19356721 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Dipyridamole results in decreased expression of ICAM1 mRNA CTD PMID:20711499 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein] CTD PMID:16765938 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dipyridamole promotes the reaction [8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Dipyridamole promotes the reaction [Bucladesine promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]; KT 5720 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]]; KT 5823 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] CTD PMID:8904084 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 decreases expression ISO Dipyridamole results in decreased expression of IL2 mRNA CTD PMID:20711499 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:16765938 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insr insulin receptor multiple interactions ISO Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein] CTD PMID:15694368 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Dipyridamole results in decreased activity of KCNH2 protein CTD PMID:17146843 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lep leptin multiple interactions
increases expression
EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO Dipyridamole results in increased activity of MAPK8 protein CTD PMID:11051267 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:16765938 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP
ISO
Dipyridamole results in increased expression of NOS2 mRNA; Dipyridamole results in increased expression of NOS2 protein
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:8904084, PMID:12271277, PMID:16765938 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppb natriuretic peptide B increases expression ISO Dipyridamole results in increased expression of NPPB protein CTD PMID:18037770 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Dipyridamole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Orm1 orosomucoid 1 multiple interactions
affects binding
ISO Dipyridamole inhibits the reaction [Warfarin binds to ORM1 protein alternative form]
Dipyridamole binds to ORM1 protein alternative form
CTD PMID:8946472 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Pde10a phosphodiesterase 10A multiple interactions ISO Dipyridamole inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic AMP]; Dipyridamole inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic GMP] CTD PMID:10373451 NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450
JBrowse link
G Pde11a phosphodiesterase 11A multiple interactions ISO Dipyridamole inhibits the reaction [PDE11A protein results in increased hydrolysis of Cyclic GMP] CTD PMID:10725373 NCBI chr 3:62,818,502...63,211,843
Ensembl chr 3:62,818,502...63,211,845
JBrowse link
G Pde4b phosphodiesterase 4B increases expression ISO Dipyridamole results in increased expression of PDE4B mRNA CTD PMID:20711499 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pde5a phosphodiesterase 5A decreases activity ISO Dipyridamole results in decreased activity of PDE5A protein CTD PMID:11051267 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Pde7a phosphodiesterase 7A multiple interactions ISO Dipyridamole inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 NCBI chr 2:104,042,124...104,134,101
Ensembl chr 2:104,045,811...104,134,101
JBrowse link
G Pde7b phosphodiesterase 7B multiple interactions ISO Dipyridamole inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442, PMID:10814504, PMID:10872825 NCBI chr 1:15,889,845...16,203,909
Ensembl chr 1:15,893,533...16,203,909
JBrowse link
G Pde8a phosphodiesterase 8A multiple interactions ISO Dipyridamole inhibits the reaction [PDE8A protein results in increased metabolism of Cyclic AMP]
Dipyridamole inhibits the reaction [PDE8A protein results in increased hydrolysis of Cyclic AMP]
CTD PMID:9671792, PMID:12681444 NCBI chr 1:143,036,083...143,160,395
Ensembl chr 1:143,036,218...143,159,433
JBrowse link
G Pde8b phosphodiesterase 8B multiple interactions ISO Dipyridamole inhibits the reaction [PDE8B protein results in increased hydrolysis of Cyclic AMP]; Dipyridamole inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP] CTD PMID:9784418, PMID:12681444 NCBI chr 2:24,718,548...24,955,533
Ensembl chr 2:24,719,976...24,923,128
JBrowse link
G Plat plasminogen activator, tissue type increases secretion
multiple interactions
ISO Dipyridamole results in increased secretion of PLAT protein
KT 5823 inhibits the reaction [Dipyridamole results in increased secretion of PLAT protein]
CTD PMID:15733978 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; triptolide inhibits the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; tin protoporphyrin IX inhibits the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
CTD PMID:16765938, PMID:20940016 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rcan1 regulator of calcineurin 1 affects binding ISO Dipyridamole binds to RCAN1 protein alternative form CTD PMID:19189965 NCBI chr11:32,539,689...32,620,274
Ensembl chr11:32,539,683...32,550,539
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dipyridamole inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Dipyridamole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions
decreases activity
ISO Dipyridamole inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]]
Dipyridamole inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dipyridamole promotes the reaction [[SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine]
Dipyridamole results in decreased activity of SLC29A1 protein
CTD PMID:9353301, PMID:9396714, PMID:10366666, PMID:11085929, PMID:11179696, PMID:21678404, PMID:21872611, PMID:28041785 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Dipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]]
Dipyridamole inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]
CTD PMID:10366666, PMID:11085929 NCBI chr 1:220,306,622...220,314,631
Ensembl chr 1:220,400,855...220,407,189
Ensembl chr 1:220,400,855...220,407,189
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Dipyridamole inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) multiple interactions ISO Dipyridamole inhibits the reaction [SLC4A1 protein results in increased transport of Chlorides] CTD PMID:2511191 NCBI chr10:90,296,144...90,312,401
Ensembl chr10:90,296,141...90,312,386
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Dinitrochlorobenzene inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]; Dipyridamole inhibits the reaction [Glucose results in increased expression of SPP1 mRNA]; Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]; DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]]; KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; tin protoporphyrin IX inhibits the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]] CTD PMID:19356721, PMID:20453393 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]] CTD PMID:11576339 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase decreases expression EXP Dipyridamole results in decreased expression of TH protein CTD PMID:17568153 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Dipyridamole results in decreased expression of TNF mRNA CTD PMID:20711499 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]; KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]] CTD PMID:20453393 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO Dipyridamole inhibits the reaction [UGT1A1 protein results in increased glucuronidation of anhydroicaritin] CTD PMID:30237061 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO Dipyridamole results in decreased expression of VCAM1 mRNA CTD PMID:20711499 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion
multiple interactions
ISO Dipyridamole results in increased secretion of VEGFA protein
Adenosine promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Heparitin Sulfate promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Hyaluronic Acid promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Lipopolysaccharides promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]
CTD PMID:20067761 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

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  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            cardiovascular drug 7613
              vasodilator agent 5729
                dipyridamole 60
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        tertiary amino compound 8629
                                          dipyridamole 60
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.