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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:465284 term browser browse the term
Definition:An oxopurine that is guanine substituted by a [(1,3-dihydroxypropan-2-yl)oxy]methyl group at position 9. Ganciclovir is an antiviral drug used to treat or prevent AIDS-related cytomegalovirus infections.
Synonyms:exact_synonym: 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
 related_synonym: 2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol;   2-Amino-9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one;   2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one;   2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one;   2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol;   2-amino-9-(2-hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone;   9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine;   9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE;   9-[(1,3-dihydroxy-2-propoxy)methyl]guanine;   Formula=C9H13N5O4;   GA2;   InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17);   InChIKey=IRSCQMHQWWYFCW-UHFFFAOYSA-N;   SMILES=Nc1nc2n(COC(CO)CO)cnc2c(=O)[nH]1;   ganciclovirum;   gancyclovir
 alt_id: CHEBI:42659;   CHEBI:5273
 xref: Beilstein:3654487;   CAS:82410-32-0;   DrugBank:DB01004;   Drug_Central:1277;   HMDB:HMDB0015139;   KEGG:D00333;   LINCS:LSM-5382
 xref_mesh: MESH:D015774
 xref: PDBeChem:GA2;   PMID:10197958;   PMID:10377226;   PMID:10411487;   PMID:10447945;   PMID:10560739;   PMID:10691698;   PMID:10882370;   PMID:10882372;   PMID:10882374;   PMID:10882375;   PMID:10888336;   PMID:10966740;   PMID:10966745;   PMID:10999475;   PMID:11229780;   PMID:11262090;   PMID:11412988;   PMID:11454465;   PMID:11472207;   PMID:11495586;   PMID:11585457;   PMID:11677126;   PMID:11708924;   PMID:11708929;   PMID:11754587;   PMID:11814776;   PMID:11858989;   PMID:11985471;   PMID:12408716;   PMID:12459010;   PMID:12723951;   PMID:1310744;   PMID:1319491;   PMID:1323678;   PMID:14521407;   PMID:14584954;   PMID:14643328;   PMID:14643358;   PMID:14736238;   PMID:15027877;   PMID:15081019;   PMID:15481985;   PMID:15509173;   PMID:15509174;   PMID:15509175;   PMID:15509176;   PMID:15615545;   PMID:15634003;   PMID:15658858;   PMID:15658861;   PMID:15658873;   PMID:15689173;   PMID:15745823;   PMID:15801851;   PMID:16134946;   PMID:16392791;   PMID:16392824;   PMID:16420056;   PMID:16480257;   PMID:1652016;   PMID:16759112;   PMID:16814545;   PMID:17004726;   PMID:17043128;   PMID:17092728;   PMID:17161946;   PMID:17181158;   PMID:17181162;   PMID:17188402;   PMID:17239594;   PMID:17298047;   PMID:17329103;   PMID:17402726;   PMID:17434304;   PMID:17438061;   PMID:17513108;   PMID:17518459;   PMID:17539622;   PMID:17622128;   PMID:17672445;   PMID:17869124;   PMID:17948980;   PMID:17960926;   PMID:18082410;   PMID:1849998;   PMID:2157013;   PMID:2160539;   PMID:2163453;   PMID:2163454;   PMID:2165163;   PMID:2175356;   PMID:2329551;   PMID:2329561;   PMID:2391689;   PMID:2500527;   PMID:2544723;   PMID:2822928;   PMID:2826784;   PMID:2840500;   PMID:2842505;   PMID:2846837;   PMID:2848125;   PMID:2913300;   PMID:2989523;   PMID:2993615;   PMID:3009811;   PMID:3016263;   PMID:3871860;   PMID:7562929;   PMID:7562946;   PMID:7562947;   PMID:7752205;   PMID:7877148;   PMID:7932543;   PMID:8071942;   PMID:8176714;   PMID:8254613;   PMID:8394933;   PMID:8632412;   PMID:8709116;   PMID:8765514;   PMID:8784444;   PMID:8784445;   PMID:8941388;   PMID:9046339;   PMID:9057866;   PMID:9057867;   PMID:9057868;   PMID:9216836;   PMID:9438017;   PMID:9548814;   PMID:9575044;   PMID:9836613;   PMID:9836626;   PMID:9871553;   PMID:9925738;   PMID:9934470;   PMID:9934471;   Patent:US4355032;   Reaxys:3654487;   Wikipedia:Ganciclovir

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ganciclovir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Ganciclovir results in decreased expression of BCL2 protein CTD PMID:15592511 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Ganciclovir results in increased expression of MDM2 protein CTD PMID:15592511 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
ISO Ganciclovir results in increased secretion of TNF protein
Sulfasalazine promotes the reaction [Ganciclovir results in increased secretion of TNF protein]
CTD PMID:17143539 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Ganciclovir results in increased expression of TP53 protein CTD PMID:15592511 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

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  CHEBI ontology 19767
    role 19714
      application 19403
        pharmaceutical 19303
          drug 19303
            antiinfective agent 13449
              ganciclovir 4
                valganciclovir 0
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  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    p-block element atom 19657
                      carbon group element atom 19573
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19496
                              organic cyclic compound 19322
                                organic heterocyclic compound 18510
                                  organic heteropolycyclic compound 17978
                                    organic heterobicyclic compound 16785
                                      imidazopyrimidine 5595
                                        purines 5593
                                          aminopurine 4424
                                            2-aminopurines 4032
                                              guanine 3996
                                                ganciclovir 4
                                                  valganciclovir 0
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