Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-phenylthiourea
go back to main search page
Accession:CHEBI:46261 term browser browse the term
Definition:A member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by a phenyl group. Depending on their genetic makeup, humans find it either very bitter-tasting or tasteless. This unusual property resulted in N-phenylthiourea being used in paternity testing prior to the advent of DNA testing.
Synonyms:exact_synonym: 1-phenylthiourea
 related_synonym: 1-phenyl-2-thiourea;   Formula=C7H8N2S;   InChI=1S/C7H8N2S/c8-7(10)9-6-4-2-1-3-5-6/h1-5H,(H3,8,9,10);   InChIKey=FULZLIGZKMKICU-UHFFFAOYSA-N;   PTC;   PTU;   PhNHC(S)NH2;   PhNHCSNH2;   SMILES=NC(=S)Nc1ccccc1;   alpha-phenylthiourea;   monophenyl thiourea;   phenyl-2-thiourea;   phenylthiocarbamide;   phenylthiourea
 xref: CAS:103-85-5;   DrugBank:DB03694
 xref_mesh: MESH:D010670
 xref: MetaCyc:CPD-7084;   PDBeChem:URS;   PMID:13914407;   PMID:20484932;   PMID:21534859;   PMID:22656649;   PMID:22690050;   PMID:22761952;   PMID:23598058;   PMID:25962731;   PMID:26005654;   PMID:26226450;   PMID:27402661;   PMID:4113332;   PMID:834304;   Reaxys:907309;   Wikipedia:Phenylthiocarbamide


show annotations for term's descendants           Sort by:
N-phenylthiourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 decreases activity ISO Phenylthiourea analog results in decreased activity of CA1 protein CTD PMID:30291660 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Phenylthiourea analog results in decreased activity of CA2 protein CTD PMID:30291660 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp9 caspase 9 increases expression ISO Phenylthiourea results in increased expression of CASP9 protein CTD PMID:16447258 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases response to substance ISO FMO3 protein results in increased susceptibility to Phenylthiourea CTD PMID:12093470 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Phenylthiourea results in decreased expression of FOS protein CTD PMID:18003792 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Phenylthiourea results in increased phosphorylation of MAPK1 protein CTD PMID:26051519 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Phenylthiourea results in increased phosphorylation of MAPK3 protein CTD PMID:26051519 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mitf melanocyte inducing transcription factor increases expression ISO Phenylthiourea results in increased expression of MITF protein CTD PMID:26051519 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Phenylthiourea results in increased expression of PPARA protein CTD PMID:16447258 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Phenylthiourea results in increased expression of RELA protein CTD PMID:16447258 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tas2r138 taste receptor, type 2, member 138 affects response to substance
multiple interactions
increases activity
affects activity		 ISO TAS2R38 gene polymorphism affects the susceptibility to Phenylthiourea
4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]; Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]
Phenylthiourea affects the activity of TAS2R38		 CTD PMID:17684414 PMID:21629661 PMID:22384968 NCBI chr 4:69,428,344...69,429,339
Ensembl chr 4:69,428,344...69,429,339 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      chemical role 19442
        antioxidant 16141
          thiourea 34
            N-phenylthiourea 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          carbamoyl group 17549
                                            carboxamide 17549
                                              monocarboxylic acid amide 15680
                                                urea 5579
                                                  ureas 5577
                                                    thiourea 34
                                                      N-phenylthiourea 11
paths to the root