CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: N-phenylthiourea
Accession: CHEBI:46261
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Definition: A member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by a phenyl group. Depending on their genetic makeup, humans find it either very bitter-tasting or tasteless. This unusual property resulted in N-phenylthiourea being used in paternity testing prior to the advent of DNA testing.
Synonyms: exact_synonym: 1-phenylthiourea
related_synonym: 1-phenyl-2-thiourea; Formula=C7H8N2S; InChI=1S/C7H8N2S/c8-7(10)9-6-4-2-1-3-5-6/h1-5H,(H3,8,9,10); InChIKey=FULZLIGZKMKICU-UHFFFAOYSA-N; PTC; PTU; PhNHC(S)NH2; PhNHCSNH2; SMILES=NC(=S)Nc1ccccc1; alpha-phenylthiourea; monophenyl thiourea; phenyl-2-thiourea; phenylthiocarbamide; phenylthiourea
xref: CAS:103-85-5; DrugBank:DB03694
xref_mesh: MESH:D010670
xref: MetaCyc:CPD-7084; PDBeChem:URS; PMID:13914407; PMID:20484932; PMID:21534859; PMID:22656649; PMID:22690050; PMID:22761952; PMID:23598058; PMID:25962731; PMID:26005654; PMID:26226450; PMID:27402661; PMID:4113332; PMID:834304; Reaxys:907309; Wikipedia:Phenylthiocarbamide
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Car1
carbonic anhydrase 1
decreases activity
ISO
Phenylthiourea analog results in decreased activity of CA1 protein
CTD
PMID:30291660
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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Car2
carbonic anhydrase 2
decreases activity
ISO
Phenylthiourea analog results in decreased activity of CA2 protein
CTD
PMID:30291660
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Casp9
caspase 9
increases expression
ISO
Phenylthiourea results in increased expression of CASP9 protein
CTD
PMID:16447258
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Fmo3
flavin containing dimethylaniline monoxygenase 3
increases response to substance
ISO
FMO3 protein results in increased susceptibility to Phenylthiourea
CTD
PMID:12093470
NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
Phenylthiourea results in decreased expression of FOS protein
CTD
PMID:18003792
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
Phenylthiourea results in increased phosphorylation of MAPK1 protein
CTD
PMID:26051519
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
Phenylthiourea results in increased phosphorylation of MAPK3 protein
CTD
PMID:26051519
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mitf
melanocyte inducing transcription factor
increases expression
ISO
Phenylthiourea results in increased expression of MITF protein
CTD
PMID:26051519
NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
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Ppara
peroxisome proliferator activated receptor alpha
increases expression
ISO
Phenylthiourea results in increased expression of PPARA protein
CTD
PMID:16447258
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Rela
RELA proto-oncogene, NF-kB subunit
increases expression
ISO
Phenylthiourea results in increased expression of RELA protein
CTD
PMID:16447258
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Tas2r138
taste receptor, type 2, member 138
affects response to substance multiple interactions increases activity affects activity
ISO
TAS2R38 gene polymorphism affects the susceptibility to Phenylthiourea 4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]; Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein] Phenylthiourea affects the activity of TAS2R38
CTD
PMID:17684414 PMID:21629661 PMID:22384968
NCBI chr 4:69,428,344...69,429,339
Ensembl chr 4:69,428,344...69,429,339
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