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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Dimethyl phthalate
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Accession:CHEBI:4609 term browser browse the term
Definition:A phthalate ester that has formula C10H10O4.
Synonyms:related_synonym: Formula=C10H10O4;   InChI=1S/C10H10O4/c1-13-9(11)7-5-3-4-6-8(7)10(12)14-2/h3-6H,1-2H3;   InChIKey=NIQCNGHVCWTJSM-UHFFFAOYSA-N;   SMILES=COC(=O)c1ccccc1C(=O)OC
 xref: CAS:131-11-3;   Drug_Central:4771;   KEGG:C11233
 xref_mesh: MESH:C024629
 xref: PPDB:2989;   VSDB:2989



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Dimethyl phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions
ISO dimethyl phthalate results in increased expression of ABCC2 mRNA
[dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate] results in increased expression of ABCC2 mRNA
CTD PMID:35739735 NCBI chr 1:252,613,875...252,672,459 JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression
ISO [dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate] results in increased expression of ABCC3 mRNA
dimethyl phthalate results in increased expression of ABCC3 mRNA
CTD PMID:35739735 NCBI chr10:79,793,571...79,839,528 JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
increases expression
ISO [dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate] results in increased expression of ABCC4 mRNA
dimethyl phthalate results in increased expression of ABCC4 mRNA
CTD PMID:35739735 NCBI chr15:101,948,387...102,182,912 JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression
multiple interactions
ISO dimethyl phthalate results in increased expression of ABCG2 mRNA
[dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate] results in increased expression of ABCG2 mRNA
CTD PMID:35739735 NCBI chr 4:89,006,056...89,132,915 JBrowse link
G Afp alpha-fetoprotein affects binding EXP dimethyl phthalate binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476 JBrowse link
G Ar androgen receptor multiple interactions ISO dimethyl phthalate analog inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; dimethyl phthalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:20943248 PMID:28571686 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression EXP dimethyl phthalate results in increased expression of BAK1 mRNA CTD PMID:35598668 NCBI chr20:5,102,334...5,111,615 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP dimethyl phthalate results in increased expression of BAX mRNA CTD PMID:35598668 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP dimethyl phthalate results in increased expression of BCL2 mRNA CTD PMID:35598668 NCBI chr13:23,204,464...23,366,900 JBrowse link
G Bid BH3 interacting domain death agonist increases expression EXP dimethyl phthalate results in increased expression of BID mRNA CTD PMID:35598668 NCBI chr 4:155,785,366...155,808,775 JBrowse link
G Casp2 caspase 2 increases expression EXP dimethyl phthalate results in increased expression of CASP2 mRNA CTD PMID:35598668 NCBI chr 4:72,116,265...72,134,023 JBrowse link
G Casp3 caspase 3 increases expression EXP dimethyl phthalate results in increased expression of CASP3 mRNA CTD PMID:35598668 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp7 caspase 7 increases expression EXP dimethyl phthalate results in increased expression of CASP7 mRNA CTD PMID:35598668 NCBI chr 1:265,442,647...265,481,938 JBrowse link
G Casp8 caspase 8 increases expression EXP dimethyl phthalate results in increased expression of CASP8 mRNA CTD PMID:35598668 NCBI chr 9:67,747,109...67,806,699 JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression
multiple interactions
EXP
ISO
dimethyl phthalate results in increased expression of CYP11A1 mRNA
[dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate] results in decreased expression of CYP11A1 mRNA
CTD PMID:26472102 PMID:35739735 NCBI chr 8:67,318,665...67,330,196 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP dimethyl phthalate results in decreased activity of CYP1A2 protein CTD PMID:27432241 NCBI chr 8:66,971,261...66,978,149 JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP dimethyl phthalate results in decreased activity of CYP2B1 protein CTD PMID:27432241 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Fadd Fas associated via death domain increases expression EXP dimethyl phthalate results in increased expression of FADD mRNA CTD PMID:35598668 NCBI chr 1:209,169,245...209,175,423 JBrowse link
G Fas Fas cell surface death receptor increases expression EXP dimethyl phthalate results in increased expression of FAS mRNA CTD PMID:35598668 NCBI chr 1:241,212,155...241,245,774 JBrowse link
G Faslg Fas ligand increases expression EXP dimethyl phthalate results in increased expression of FASLG mRNA CTD PMID:35598668 NCBI chr13:76,680,885...76,706,042 JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO [dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate] results in increased expression of HSD3B1 mRNA CTD PMID:35739735 NCBI chr 2:186,169,864...186,175,984 JBrowse link
G Ifng interferon gamma decreases expression EXP dimethyl phthalate results in decreased expression of IFNG protein CTD PMID:35598668 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP dimethyl phthalate results in decreased expression of IGF1 mRNA CTD PMID:26472102 NCBI chr 7:24,169,608...24,249,446 JBrowse link
G Il4 interleukin 4 decreases expression EXP dimethyl phthalate results in decreased expression of IL4 protein CTD PMID:35598668 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Il6 interleukin 6 decreases expression EXP dimethyl phthalate results in decreased expression of IL6 protein CTD PMID:35598668 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Msh2 mutS homolog 2 decreases expression EXP dimethyl phthalate results in decreased expression of MSH2 mRNA CTD PMID:26472102 NCBI chr 6:12,567,368...12,626,534 JBrowse link
G Myocd myocardin decreases expression EXP dimethyl phthalate results in decreased expression of MYOCD mRNA CTD PMID:26472102 NCBI chr10:50,332,356...50,426,819 JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects binding ISO dimethyl phthalate binds to NR1I3 protein CTD PMID:25938866 NCBI chr13:86,165,327...86,170,362 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects binding ISO dimethyl phthalate binds to PPARA protein CTD PMID:23843199 NCBI chr 7:118,712,261...118,780,723 JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding ISO dimethyl phthalate binds to PPARB protein CTD PMID:23843199 NCBI chr20:6,300,527...6,365,707 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding ISO dimethyl phthalate binds to PPARG protein CTD PMID:23843199 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO dimethyl phthalate binds to RXRA protein CTD PMID:23843199 NCBI chr 3:31,387,892...31,474,415 JBrowse link
G Rxrb retinoid X receptor beta affects binding ISO dimethyl phthalate binds to RXRB protein CTD PMID:23843199 NCBI chr20:4,816,813...4,823,267 JBrowse link
G Rxrg retinoid X receptor gamma affects binding ISO dimethyl phthalate binds to RXRG protein CTD PMID:23843199 NCBI chr13:82,276,330...82,318,097 JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
multiple interactions
EXP
ISO
dimethyl phthalate results in decreased expression of SCARB1 mRNA
[dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate] results in increased expression of SCARB1 mRNA
CTD PMID:26472102 PMID:35739735 NCBI chr12:36,957,302...37,023,982 JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP dimethyl phthalate results in decreased expression of SOD1 protein CTD PMID:35598668 NCBI chr11:42,942,742...42,948,399 JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
multiple interactions
EXP
ISO
dimethyl phthalate results in decreased expression of STAR mRNA
[dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate] results in decreased expression of STAR mRNA
CTD PMID:26472102 PMID:35739735 NCBI chr16:72,969,824...72,974,447 JBrowse link

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  CHEBI ontology 19898
    role 19869
      application 19715
        fuel 11375
          methanol 3989
            methyl ester 3934
              Dimethyl phthalate 37
Path 2
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  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carboxylic acid 18679
                                      aromatic carboxylic acid 12748
                                        benzoic acids 12726
                                          benzenedicarboxylic acid 8802
                                            phthalic acid 8570
                                              phthalate ester 8570
                                                Dimethyl phthalate 37
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