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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dimenhydrinate
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Accession:CHEBI:4604 term browser browse the term
Definition:The diphenhydramine salt of 8-chlorotheophylline. Its effects are similar to those of diphenhydramine, but it is less potent. It was thought that by combining the antiemetic effects of diphenhydramine with the mild stimulant effects of 8-chlorotheophyline, the extreme drowsiness induced by the former would be mitigated. However, the sedation caused by diphenhydramine is considerably stronger than the stimulation caused by 8-chlorotheophylline. Dimenhydrinate is used mainly as an antiemetic in the prevention and treatment of motion sickness.
Synonyms:exact_synonym: 2-(diphenylmethoxy)-N,N-dimethylethanaminium 8-chloro-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-ide
 related_synonym: (O-benzhydryl(dimethylamino)ethanol) 8-chlorotheophyllinate;   8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1);   Benzhydryl-beta-dimethylaminoethylether 8-chlorotheophylline;   Formula=C24H28ClN5O3;   InChI=1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10,13);   InChIKey=DKHVTDUUNTVKOW-UHFFFAOYSA-N;   N,N-dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinate;   O-benzhydryldimethylaminoethanol 8-chlorotheophyllinate;   SMILES=Cn1c2nc(Cl)[n-]c2c(=O)n(C)c1=O.C[NH+](C)CCOC(c1ccccc1)c1ccccc1;   beta-dimethylaminoethyl benzhydryl ether 1,3-dimethyl-8-chloroxanthine;   dimenhidrinato;   dimenhydrinatum;   diphenhydramine 8-chlorotheophyllinate;   diphenhydramine 8-chlorotheophylline;   diphenhydramine theoclate
 xref: CAS:523-87-5;   DrugBank:DB00985;   KEGG:D00520
 xref_mesh: MESH:D004111
 xref: Patent:US2499058;   Patent:US2534813


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dimenhydrinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO Dimenhydrinate results in decreased activity of BCHE protein CTD PMID:236606 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
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G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dimenhydrinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            antiemetic 5131
              dimenhydrinate 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17243
                                  azane 16960
                                    ammonia 16959
                                      organic amino compound 16958
                                        tertiary amino compound 8643
                                          diphenhydramine 15
                                            dimenhydrinate 2
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