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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:46020 term browser browse the term
Definition:The simplest quaternary ammonium cation, comprising a central nitrogen linked to four methyl groups.
Synonyms:exact_synonym: N,N,N-trimethylmethanaminium
 related_synonym: (CH3)4N(+);   Formula=C4H12N;   InChI=1S/C4H12N/c1-5(2,3)4/h1-4H3/q+1;   InChIKey=QEMXHQIAXOOASZ-UHFFFAOYSA-N;   SMILES=C[N+](C)(C)C;   TETRAMETHYLAMMONIUM ION;   [NMe4](+);   tetramethylazanium;   trimethylaminomethane
 alt_id: CHEBI:35264;   CHEBI:46018
 xref: Beilstein:1733140;   CAS:51-92-3;   DrugBank:DB03095;   Gmelin:1858
 xref_mesh: MESH:C027917
 xref: PDBeChem:TMA;   PMID:10421447;   PMID:10788331;   Reaxys:1733140;   Wikipedia:Tetramethylammonium

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tetramethylammonium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO tetramethylammonium results in decreased activity of BCHE protein CTD PMID:31173753 NCBI chr 3:73,635,805...73,708,436
Ensembl chr 3:73,635,808...73,708,415
JBrowse link
G Slc22a27 solute carrier family 22, member 27 multiple interactions EXP tetramethylammonium inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine] CTD PMID:20332632 NCBI chr19:7,864,388...7,966,517
Ensembl chr19:7,864,388...7,966,027
JBrowse link
G Slc47a1 solute carrier family 47, member 1 multiple interactions ISO tetramethylammonium affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; tetramethylammonium inhibits the reaction [SLC47A1 protein affects the uptake of Paraquat] CTD PMID:17495125 PMID:22419765 NCBI chr11:61,343,400...61,378,842
Ensembl chr11:61,343,401...61,378,345
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21737
    chemical entity 21735
      molecular entity 21722
        ion 16633
          organic ion 8634
            organic cation 7456
              quaternary ammonium ion 5257
                tetramethylammonium 3
                  tetramethylammonium bromide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21737
    subatomic particle 21723
      composite particle 21723
        hadron 21723
          baryon 21723
            nucleon 21723
              atomic nucleus 21723
                atom 21723
                  main group element atom 21638
                    main group molecular entity 21638
                      s-block molecular entity 21174
                        hydrogen molecular entity 21111
                          hydrides 20360
                            inorganic hydride 18058
                              pnictogen hydride 18021
                                nitrogen hydride 17840
                                  ammonium 8105
                                    ammonium ion derivative 8101
                                      quaternary ammonium ion 5257
                                        tetramethylammonium 3
                                          tetramethylammonium bromide 0
paths to the root