CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: thiabendazole
Accession: CHEBI:45979
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Definition: A member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium.
Synonyms: related_synonym: 2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE; 2-(1,3-thiazol-4-yl)benzimidazole; 2-(4-thiazolyl)-1H-benzimidazole; 2-(thiazol-4-yl)benzimidazole; 4-(2-benzimidazolyl)thiazole; Equizole; Formula=C10H7N3S; InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13); InChIKey=WJCNZQLZVWNLKY-UHFFFAOYSA-N; MK 360; Mintezol; SMILES=c1nc(cs1)-c1nc2ccccc2[nH]1; TBZ; Thibenzole; Tiabendazole
alt_id: CHEBI:45977; CHEBI:9526
xref: Beilstein:611403; CAS:148-79-8; DrugBank:DB00730; Drug_Central:2621; HMDB:HMDB0014868; KEGG:D00372; LINCS:LSM-3741
xref_mesh: MESH:D013827
xref: MetaCyc:THIABENDAZOLE; PDBeChem:TMG; PMID:11226373; PMID:13900465; PMID:23790859; PMID:9009055; PPDB:629; Patent:US3017415; Pesticides:thiabendazole; Reaxys:611403; VSDB:629; Wikipedia:Thiabendazole
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Alb
albumin
decreases expression
EXP
Thiabendazole results in decreased expression of ALB mRNA
CTD
PMID:18539377
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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Casp3
caspase 3
increases activity
EXP
Thiabendazole results in increased activity of CASP3 protein
CTD
PMID:26748015
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp8
caspase 8
increases activity
EXP
Thiabendazole results in increased activity of CASP8 protein
CTD
PMID:26748015
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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Casp9
caspase 9
increases activity
EXP
Thiabendazole results in increased activity of CASP9 protein
CTD
PMID:26748015
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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Chmp5
charged multivesicular body protein 5
affects expression
EXP
Thiabendazole affects the expression of CHMP5 mRNA
CTD
PMID:18539377
NCBI chr 5:57,267,312...57,284,455
Ensembl chr 5:57,267,312...57,284,448
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions increases expression increases activity
EXP ISO
herbimycin inhibits the reaction [Thiabendazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 protein] Thiabendazole results in increased expression of CYP1A1 mRNA; Thiabendazole results in increased expression of CYP1A1 protein
CTD
PMID:8900397 PMID:10103034 PMID:11226373 PMID:14987951 PMID:15110098
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions increases expression affects metabolic processing decreases activity
ISO EXP
beta-Naphthoflavone promotes the reaction [CYP1A2 protein affects the metabolism of Thiabendazole] Thiabendazole results in increased expression of CYP1A2 mRNA; Thiabendazole results in increased expression of CYP1A2 protein Thiabendazole results in decreased activity of CYP1A2 protein
CTD
PMID:10936227 PMID:11124226 PMID:12920490 PMID:15110098 PMID:16261361 PMID:18539377 PMID:18570159
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
EXP
Thiabendazole results in increased expression of CYP2B1 mRNA; Thiabendazole results in increased expression of CYP2B1 protein
CTD
PMID:15110098
NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
increases expression
EXP
Thiabendazole results in increased expression of CYP2B2 mRNA; Thiabendazole results in increased expression of CYP2B2 protein
CTD
PMID:15110098
NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression
ISO
Thiabendazole results in increased expression of CYP2B6 mRNA
CTD
PMID:18570159
NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
increases expression
ISO
Thiabendazole results in increased expression of CYP3A4 mRNA
CTD
PMID:18570159
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
EXP
Thiabendazole results in increased expression of GADD45A mRNA
CTD
PMID:18539377
NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases activity multiple interactions
ISO
Thiabendazole results in increased activity of GCLC protein [Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein
CTD
PMID:11019651
NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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Gstp1
glutathione S-transferase pi 1
increases expression
EXP
Thiabendazole results in increased expression of GSTP1 mRNA
CTD
PMID:15110098
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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Gstt1
glutathione S-transferase theta 1
increases expression
EXP
Thiabendazole results in increased expression of GSTT1 mRNA
CTD
PMID:15110098
NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
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Mpo
myeloperoxidase
increases metabolic processing
ISO
MPO protein results in increased metabolism of Thiabendazole metabolite
CTD
PMID:21513789
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
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Nppb
natriuretic peptide B
increases expression
EXP
Thiabendazole results in increased expression of NPPB mRNA
CTD
PMID:18539377
NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
Thiabendazole results in increased activity of NR1I2 protein
CTD
PMID:25455453
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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Oxct1
3-oxoacid CoA transferase 1
affects expression
EXP
Thiabendazole affects the expression of OXCT1 mRNA
CTD
PMID:18539377
NCBI chr 2:53,859,738...54,007,733
Ensembl chr 2:53,859,737...54,007,756
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Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
increases expression
EXP
Thiabendazole results in increased expression of PFKFB1 mRNA
CTD
PMID:18539377
NCBI chr X:23,092,143...23,145,923
Ensembl chr X:23,092,159...23,144,324
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Prkcb
protein kinase C, beta
increases expression
EXP
Thiabendazole results in increased expression of PRKCB mRNA
CTD
PMID:18539377
NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
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Taf9b
TATA-box binding protein associated factor 9b
affects expression
EXP
Thiabendazole affects the expression of TAF9B mRNA
CTD
PMID:18539377
NCBI chr X:77,281,234...77,295,238
Ensembl chr X:77,281,210...77,295,426
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Tp53
tumor protein p53
increases expression
EXP
Thiabendazole results in increased expression of TP53 mRNA
CTD
PMID:18539377
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Trim3
tripartite motif-containing 3
increases expression
EXP
Thiabendazole results in increased expression of TRIM3 mRNA
CTD
PMID:18539377
NCBI chr 1:170,441,662...170,464,341
Ensembl chr 1:170,441,639...170,464,341
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Ugdh
UDP-glucose 6-dehydrogenase
increases expression
EXP
Thiabendazole results in increased expression of UGDH mRNA
CTD
PMID:18539377
NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
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Utrn
utrophin
increases expression
ISO
Thiabendazole results in increased expression of UTRN mRNA
CTD
PMID:22028826
NCBI chr 1:6,451,809...6,970,040
Ensembl chr 1:6,451,810...6,970,040
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