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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thiabendazole
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Accession:CHEBI:45979 term browser browse the term
Definition:A member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium.
Synonyms:related_synonym: 2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE;   2-(1,3-thiazol-4-yl)benzimidazole;   2-(4-thiazolyl)-1H-benzimidazole;   2-(thiazol-4-yl)benzimidazole;   4-(2-benzimidazolyl)thiazole;   Equizole;   Formula=C10H7N3S;   InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13);   InChIKey=WJCNZQLZVWNLKY-UHFFFAOYSA-N;   MK 360;   Mintezol;   SMILES=c1nc(cs1)-c1nc2ccccc2[nH]1;   TBZ;   Thibenzole;   Tiabendazole
 alt_id: CHEBI:45977;   CHEBI:9526
 xref: Beilstein:611403;   CAS:148-79-8;   DrugBank:DB00730;   Drug_Central:2621;   HMDB:HMDB0014868;   KEGG:D00372;   LINCS:LSM-3741
 xref_mesh: MESH:D013827
 xref: MetaCyc:THIABENDAZOLE;   PDBeChem:TMG;   PMID:11226373;   PMID:13900465;   PMID:23790859;   PMID:9009055;   PPDB:629;   Patent:US3017415;   Pesticides:thiabendazole;   Reaxys:611403;   VSDB:629;   Wikipedia:Thiabendazole

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thiabendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin decreases expression EXP Thiabendazole results in decreased expression of ALB mRNA CTD PMID:18539377 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Casp3 caspase 3 increases activity EXP Thiabendazole results in increased activity of CASP3 protein CTD PMID:26748015 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases activity EXP Thiabendazole results in increased activity of CASP8 protein CTD PMID:26748015 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases activity EXP Thiabendazole results in increased activity of CASP9 protein CTD PMID:26748015 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Chmp5 charged multivesicular body protein 5 affects expression EXP Thiabendazole affects the expression of CHMP5 mRNA CTD PMID:18539377 NCBI chr 5:57,267,312...57,284,455
Ensembl chr 5:57,267,312...57,284,448 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity		 EXP
ISO		 herbimycin inhibits the reaction [Thiabendazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 protein]
Thiabendazole results in increased expression of CYP1A1 mRNA; Thiabendazole results in increased expression of CYP1A1 protein		 CTD PMID:8900397 PMID:10103034 PMID:11226373 PMID:14987951 PMID:15110098 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
affects metabolic processing
decreases activity		 ISO
EXP		 beta-Naphthoflavone promotes the reaction [CYP1A2 protein affects the metabolism of Thiabendazole]
Thiabendazole results in increased expression of CYP1A2 mRNA; Thiabendazole results in increased expression of CYP1A2 protein
Thiabendazole results in decreased activity of CYP1A2 protein		 CTD PMID:10936227 PMID:11124226 PMID:12920490 PMID:15110098 PMID:16261361 PMID:18539377 PMID:18570159 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Thiabendazole results in increased expression of CYP2B1 mRNA; Thiabendazole results in increased expression of CYP2B1 protein CTD PMID:15110098 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Thiabendazole results in increased expression of CYP2B2 mRNA; Thiabendazole results in increased expression of CYP2B2 protein CTD PMID:15110098 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Thiabendazole results in increased expression of CYP2B6 mRNA CTD PMID:18570159 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression ISO Thiabendazole results in increased expression of CYP3A4 mRNA CTD PMID:18570159 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Thiabendazole results in increased expression of GADD45A mRNA CTD PMID:18539377 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
multiple interactions		 ISO Thiabendazole results in increased activity of GCLC protein
[Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein		 CTD PMID:11019651 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Thiabendazole results in increased expression of GSTP1 mRNA CTD PMID:15110098 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP Thiabendazole results in increased expression of GSTT1 mRNA CTD PMID:15110098 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526 		JBrowse link
G Mpo myeloperoxidase increases metabolic processing ISO MPO protein results in increased metabolism of Thiabendazole metabolite CTD PMID:21513789 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Nppb natriuretic peptide B increases expression EXP Thiabendazole results in increased expression of NPPB mRNA CTD PMID:18539377 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Thiabendazole results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 affects expression EXP Thiabendazole affects the expression of OXCT1 mRNA CTD PMID:18539377 NCBI chr 2:53,859,738...54,007,733
Ensembl chr 2:53,859,737...54,007,756 		JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 increases expression EXP Thiabendazole results in increased expression of PFKFB1 mRNA CTD PMID:18539377 NCBI chr  X:23,092,143...23,145,923
Ensembl chr  X:23,092,159...23,144,324 		JBrowse link
G Prkcb protein kinase C, beta increases expression EXP Thiabendazole results in increased expression of PRKCB mRNA CTD PMID:18539377 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831 		JBrowse link
G Taf9b TATA-box binding protein associated factor 9b affects expression EXP Thiabendazole affects the expression of TAF9B mRNA CTD PMID:18539377 NCBI chr  X:77,281,234...77,295,238
Ensembl chr  X:77,281,210...77,295,426 		JBrowse link
G Tp53 tumor protein p53 increases expression EXP Thiabendazole results in increased expression of TP53 mRNA CTD PMID:18539377 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trim3 tripartite motif-containing 3 increases expression EXP Thiabendazole results in increased expression of TRIM3 mRNA CTD PMID:18539377 NCBI chr 1:170,441,662...170,464,341
Ensembl chr 1:170,441,639...170,464,341 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression EXP Thiabendazole results in increased expression of UGDH mRNA CTD PMID:18539377 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845 		JBrowse link
G Utrn utrophin increases expression ISO Thiabendazole results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,451,809...6,970,040
Ensembl chr 1:6,451,810...6,970,040 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      application 19494
        pesticide 16613
          antifungal agrochemical 8078
            thiabendazole 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic heterocyclic compound 18511
                                  heteroarene 16562
                                    monocyclic heteroarene 13374
                                      azole 12544
                                        thiazoles 1251
                                          1,3-thiazoles 644
                                            thiabendazole 26
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