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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trimethoprim
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Accession:CHEBI:45924 term browser browse the term
Definition:An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Synonyms:exact_synonym: 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine
 related_synonym: 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine;   5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine;   Formula=C14H18N4O3;   InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18);   InChIKey=IEDVJHCEMCRBQM-UHFFFAOYSA-N;   Proloprim;   SMILES=C=1(CC=2C(=NC(N)=NC2)N)C=C(C(OC)=C(C1)OC)OC;   Trimpex
 alt_id: CHEBI:45921;   CHEBI:9731
 xref: Beilstein:625127;   CAS:738-70-5;   DrugBank:DB00440;   Drug_Central:2755;   Gmelin:808843;   HMDB:HMDB0014583;   KEGG:C01965;   KEGG:D00145;   LINCS:LSM-5246
 xref_mesh: MESH:D014295
 xref: PDBeChem:TOP;   PMID:10423629;   PMID:10969053;   PMID:11051625;   PMID:14629008;   PMID:15203044;   PMID:16311012;   PMID:18816075;   PMID:25111783;   PMID:25361939;   PMID:26546758;   PMID:26566149;   PMID:26942256;   PMID:26987772;   PMID:28166217;   PMID:7602118;   PMID:8911701;   Reaxys:625127;   VSDB:1745;   Wikipedia:Trimethoprim



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trimethoprim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule affects expression ISO Trimethoprim affects the expression of CD74 mRNA CTD PMID:25811541 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO [Trimethoprim results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine CTD PMID:26599973 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
decreases activity
ISO CYP2C8 protein results in increased metabolism of Trimethoprim
Trimethoprim results in decreased activity of CYP2C8 protein
CTD PMID:12464242 PMID:15570183
G Dhfr dihydrofolate reductase multiple interactions ISO [Trimethoprim results in decreased activity of DHFR protein] which results in increased susceptibility to Valproic Acid CTD PMID:8318756 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein CTD PMID:10888991 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G RT1-DOb RT1 class II, locus DOb affects expression ISO Trimethoprim affects the expression of HLA-DOB mRNA CTD PMID:25811541 NCBI chr20:4,619,599...4,625,627
Ensembl chr20:4,619,816...4,625,667
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Trimethoprim inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin] CTD PMID:24947867 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases transport ISO SLC22A3 protein results in increased transport of Trimethoprim CTD PMID:18253050 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Trimethoprim inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Trimethoprim inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
co-trimoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins2 insulin 2 increases secretion ISO Trimethoprim, Sulfamethoxazole Drug Combination results in increased secretion of INS protein modified form CTD PMID:14714756 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        xenobiotic 18633
          trimethoprim 11
            5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl group 0
            6-chlorotrimethoprim 0
            6-hydroxytrimethoprim 0
            co-trimoxazole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19744
                        hydrogen molecular entity 19736
                          hydrides 19102
                            inorganic hydride 17893
                              pnictogen hydride 17876
                                nitrogen hydride 17766
                                  azane 17518
                                    ammonia 17517
                                      organic amino compound 17517
                                        aromatic amine 14924
                                          aminopyrimidine 1601
                                            trimethoprim 11
                                              5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl group 0
                                              6-chlorotrimethoprim 0
                                              6-hydroxytrimethoprim 0
                                              co-trimoxazole 1
paths to the root