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ONTOLOGY REPORT - ANNOTATIONS


Term:trimethoprim
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Accession:CHEBI:45924 term browser browse the term
Definition:An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Synonyms:exact_synonym: 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine
 related_synonym: 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine;   5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine;   Formula=C14H18N4O3;   InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18);   InChIKey=IEDVJHCEMCRBQM-UHFFFAOYSA-N;   Proloprim;   SMILES=C=1(CC=2C(=NC(N)=NC2)N)C=C(C(OC)=C(C1)OC)OC;   Trimpex
 alt_id: CHEBI:45921;   CHEBI:9731
 xref: Beilstein:625127;   CAS:738-70-5;   DrugBank:DB00440;   Drug_Central:2755;   Gmelin:808843;   HMDB:HMDB0014583;   KEGG:C01965;   KEGG:D00145;   LINCS:LSM-5246
 xref_mesh: MESH:D014295
 xref: PDBeChem:TOP;   PMID:10423629;   PMID:10969053;   PMID:11051625;   PMID:14629008;   PMID:15203044;   PMID:16311012;   PMID:18816075;   PMID:25111783;   PMID:25361939;   PMID:26546758;   PMID:26566149;   PMID:26942256;   PMID:26987772;   PMID:28166217;   PMID:7602118;   PMID:8911701;   Reaxys:625127;   VSDB:1745;   Wikipedia:Trimethoprim


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trimethoprim term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:6480464
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G RT1-DOb RT1 class II, locus DOb JBrowse link 20 4,020,273 4,026,398 RGD:6480464
G Slc22a1 solute carrier family 22 member 1 JBrowse link 1 48,273,639 48,300,645 RGD:6480464
G Slc22a3 solute carrier family 22 member 3 JBrowse link 1 48,433,079 48,521,261 RGD:6480464
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:6480464
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:6480464
co-trimoxazole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19789
    role 19735
      biological role 19734
        xenobiotic 18411
          trimethoprim 11
            5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl group 0
            6-chlorotrimethoprim 0
            6-hydroxytrimethoprim 0
            co-trimoxazole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19789
    subatomic particle 19787
      composite particle 19787
        hadron 19787
          baryon 19787
            nucleon 19787
              atomic nucleus 19787
                atom 19787
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19415
                        hydrogen molecular entity 19405
                          hydrides 18376
                            inorganic hydride 17224
                              pnictogen hydride 17187
                                nitrogen hydride 17021
                                  azane 16716
                                    ammonia 16715
                                      organic amino compound 16714
                                        aromatic amine 13627
                                          aminopyrimidine 1101
                                            trimethoprim 11
                                              5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl group 0
                                              6-chlorotrimethoprim 0
                                              6-hydroxytrimethoprim 0
                                              co-trimoxazole 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.