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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trimethoprim
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Accession:CHEBI:45924 term browser browse the term
Definition:An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Synonyms:exact_synonym: 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine
 related_synonym: 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine;   5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine;   Formula=C14H18N4O3;   InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18);   InChIKey=IEDVJHCEMCRBQM-UHFFFAOYSA-N;   Proloprim;   SMILES=C=1(CC=2C(=NC(N)=NC2)N)C=C(C(OC)=C(C1)OC)OC;   Trimpex
 alt_id: CHEBI:45921;   CHEBI:9731
 xref: Beilstein:625127;   CAS:738-70-5;   DrugBank:DB00440;   Drug_Central:2755;   Gmelin:808843;   HMDB:HMDB0014583;   KEGG:C01965;   KEGG:D00145;   LINCS:LSM-5246
 xref_mesh: MESH:D014295
 xref: PDBeChem:TOP;   PMID:10423629;   PMID:10969053;   PMID:11051625;   PMID:14629008;   PMID:15203044;   PMID:16311012;   PMID:18816075;   PMID:25111783;   PMID:25361939;   PMID:26546758;   PMID:26566149;   PMID:26942256;   PMID:26987772;   PMID:28166217;   PMID:7602118;   PMID:8911701;   Reaxys:625127;   VSDB:1745;   Wikipedia:Trimethoprim


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trimethoprim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule affects expression ISO Trimethoprim affects the expression of CD74 mRNA CTD PMID:25811541 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO [Trimethoprim results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine CTD PMID:26599973 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
decreases activity
ISO CYP2C8 protein results in increased metabolism of Trimethoprim
Trimethoprim results in decreased activity of CYP2C8 protein
CTD PMID:12464242 PMID:15570183 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Dhfr dihydrofolate reductase multiple interactions ISO [Trimethoprim results in decreased activity of DHFR protein] which results in increased susceptibility to Valproic Acid CTD PMID:8318756 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein CTD PMID:10888991 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G RT1-DOb RT1 class II, locus DOb affects expression ISO Trimethoprim affects the expression of HLA-DOB mRNA CTD PMID:25811541 NCBI chr20:4,020,273...4,026,398
Ensembl chr20:4,020,317...4,026,346
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Trimethoprim inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin] CTD PMID:24947867 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases transport ISO SLC22A3 protein results in increased transport of Trimethoprim CTD PMID:18253050 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Trimethoprim inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Trimethoprim inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
co-trimoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins2 insulin 2 increases secretion ISO Trimethoprim, Sulfamethoxazole Drug Combination results in increased secretion of INS protein modified form CTD PMID:14714756 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        xenobiotic 18392
          trimethoprim 11
            5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl group 0
            6-chlorotrimethoprim 0
            6-hydroxytrimethoprim 0
            co-trimoxazole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    main group molecular entity 19658
                      s-block molecular entity 19423
                        hydrogen molecular entity 19416
                          hydrides 18755
                            inorganic hydride 17460
                              pnictogen hydride 17435
                                nitrogen hydride 17281
                                  azane 17017
                                    ammonia 17016
                                      organic amino compound 17015
                                        aromatic amine 13682
                                          aminopyrimidine 1296
                                            trimethoprim 11
                                              5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl group 0
                                              6-chlorotrimethoprim 0
                                              6-hydroxytrimethoprim 0
                                              co-trimoxazole 1
paths to the root