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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:suramin
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Accession:CHEBI:45906 term browser browse the term
Definition:A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Synonyms:exact_synonym: 8,8'-{carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]}dinaphthalene-1,3,5-trisulfonic acid
 related_synonym: 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID;   Belganyl;   Formula=C51H40N6O23S6;   InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);   InChIKey=FIAFUQMPZJWCLV-UHFFFAOYSA-N;   Naganol;   Naphuride;   SMILES=C12=C(C=C(C=C1C(=CC=C2NC(C3=CC=C(C(NC(C=4C=CC=C(NC(NC5=CC=CC(C(NC=6C(=CC=C(C(NC=7C8=C(C=C(C=C8C(=CC7)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)=O)C6)C)=O)=C5)=O)C4)=O)=C3)C)=O)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O
 alt_id: CHEBI:45904;   CHEBI:9363
 xref: AGR:IND606744035;   Beilstein:3230873;   Beilstein:8185304;   CAS:145-63-1;   Chemspider:5168;   DrugBank:DB04786;   Drug_Central:2966;   HMDB:HMDB0015582;   KEGG:C07974;   LINCS:LSM-5775
 xref_mesh: MESH:D013498
 xref: PDBeChem:SVR;   PMID:11549724;   PMID:15733555;   PMID:15774519;   PMID:28457855;   PMID:29414872;   PMID:30172846;   PMID:30393012;   PMID:30449075;   PMID:30528604;   PMID:30543088;   PMID:30771091;   PMID:31346035;   PMID:31409229;   PMID:31667504;   PMID:31727005;   PMID:31803569;   PMID:31844000;   PMID:7947391;   PMID:8769855;   Wikipedia:Suramin
 cyclic_relationship: is_conjugate_acid_of CHEBI:180911


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  CHEBI ontology 0
    role 0
      biological role 0
        inhibitor 0
          apoptosis inhibitor 0
            suramin 0
Path 2
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  CHEBI ontology 0
    subatomic particle 0
      composite particle 0
        hadron 0
          baryon 0
            nucleon 0
              atomic nucleus 0
                atom 0
                  main group element atom 0
                    p-block element atom 0
                      carbon group element atom 0
                        carbon atom 0
                          organic molecular entity 0
                            heteroorganic entity 0
                              organochalcogen compound 0
                                organooxygen compound 0
                                  carbon oxoacid 0
                                    carboxylic acid 0
                                      carboacyl group 0
                                        univalent carboacyl group 0
                                          carbamoyl group 0
                                            carboxamide 0
                                              monocarboxylic acid amide 0
                                                urea 0
                                                  ureas 0
                                                    phenylureas 0
                                                      suramin 0
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