CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: tert-butanol
Accession: CHEBI:45895
Definition: A tertiary alcohol alcohol that is isobutane substituted by a hydroxy group at position 2.
Synonyms: related_synonym: (CH3)3C-OH; 1,1-dimethylethanol; 2-methylpropan-2-ol; Formula=C4H10O; InChI=1S/C4H10O/c1-4(2,3)5/h5H,1-3H3; InChIKey=DKGAVHZHDRPRBM-UHFFFAOYSA-N; SMILES=CC(C)(C)O; TERTIARY-BUTYL ALCOHOL; t-Butylalkohol; t-butanol; t-butyl alchohol; tert-butyl alcohol; trimethylcarbinol; trimethylmethanol alt_id: CHEBI:26877; CHEBI:45893 xref: Beilstein:906698; CAS:75-65-0; Gmelin:1833; HMDB:HMDB0031456 xref_mesh: MESH:D020002 xref: PDBeChem:TBU; PMID:11409007; PMID:11452135; Reaxys:906698; UM-BBD_compID:c0516; Wikipedia:Tert-Butyl_alcohol
G
Alox5 arachidonate 5-lipoxygenase
multiple interactions
ISO tert-Butyl Alcohol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]
CTD PMID:18218859
NCBI chr 4:149,531,329...149,578,696
G
Chrna2 cholinergic receptor nicotinic alpha 2 subunit
multiple interactions
ISO tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]
CTD PMID:11821649
NCBI chr15:40,342,317...40,358,601
G
Chrnb4 cholinergic receptor nicotinic beta 4 subunit
multiple interactions
ISO tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]
CTD PMID:11821649
NCBI chr 8:55,417,583...55,437,027
G
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression
ISO tert-Butyl Alcohol results in increased expression of CYP2B10 mRNA
CTD PMID:19760798
NCBI chr 1:81,652,762...81,732,153
G
Gabbr1 gamma-aminobutyric acid type B receptor subunit 1
multiple interactions
ISO tert-Butyl Alcohol inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]
CTD PMID:10683198
NCBI chr20:1,464,534...1,494,114
G
Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2
multiple interactions
ISO tert-Butyl Alcohol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]
CTD PMID:10683198
NCBI chr14:37,097,251...37,230,030
G
Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1
multiple interactions
ISO tert-Butyl Alcohol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]
CTD PMID:10683198
NCBI chr14:36,068,725...36,548,946
G
Gh1 growth hormone 1
affects folding
ISO tert-Butyl Alcohol affects the folding of GH1 protein
CTD PMID:11064379
NCBI chr10:91,228,102...91,230,079
G
Glra1 glycine receptor, alpha 1
multiple interactions
ISO tert-Butyl Alcohol promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]
CTD PMID:10683198
NCBI chr10:39,625,853...39,727,897
G
Il2 interleukin 2
multiple interactions
ISO tert-Butyl Alcohol inhibits the reaction [[4-O-methyl-12-O-tetradecanoylphorbol 13-acetate co-treated with Ionomycin] results in increased expression of IL2 protein]
CTD PMID:18423386
NCBI chr 2:120,004,862...120,009,566
G
Nos2 nitric oxide synthase 2
multiple interactions
EXP tert-Butyl Alcohol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; tert-Butyl Alcohol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:10231168
NCBI chr10:63,815,308...63,851,208
G
Sirt1 sirtuin 1
increases expression
ISO tert-Butyl Alcohol results in increased expression of SIRT1 mRNA; tert-Butyl Alcohol results in increased expression of SIRT1 protein
CTD PMID:29134718
NCBI chr20:25,307,225...25,329,273
G
Slc12a2 solute carrier family 12 member 2
multiple interactions
EXP tert-Butyl Alcohol results in increased oxidation of and results in increased expression of SLC12A2 protein; tert-Butyl Alcohol results in increased phosphorylation of and results in increased activity of SLC12A2 protein
CTD PMID:25817889
NCBI chr18:51,348,282...51,416,448
G
Tnf tumor necrosis factor
multiple interactions
EXP tert-Butyl Alcohol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:10231168
NCBI chr20:3,622,011...3,624,629
G
Acta2 actin alpha 2, smooth muscle
multiple interactions
ISO 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one promotes the reaction [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased expression of ACTA2 protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased expression of ACTA2 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [polyhexamethyleneguanidine results in increased expression of ACTA2 protein]]
CTD PMID:31348943
NCBI chr 1:231,746,527...231,759,307
G
Akt1 AKT serine/threonine kinase 1
multiple interactions
ISO 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one promotes the reaction [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of AKT1 protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of AKT1 protein]
CTD PMID:31348943
NCBI chr 6:131,713,716...131,735,319
G
App amyloid beta precursor protein
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Tunicamycin results in increased secretion of APP protein modified form]
CTD PMID:22115781
NCBI chr11:24,019,774...24,236,584
G
Bax BCL2 associated X, apoptosis regulator
increases expression
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of BAX protein
CTD PMID:21209419 PMID:34897970
NCBI chr 1:95,940,001...95,945,407
G
Bcl2 BCL2, apoptosis regulator
decreases expression
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of BCL2 protein
CTD PMID:21209419 PMID:34897970
NCBI chr13:22,689,783...22,853,920
G
Bmp6 bone morphogenetic protein 6
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT10 mRNA]
CTD PMID:23566955
NCBI chr17:26,318,121...26,469,691
G
Casp3 caspase 3
multiple interactions
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP3 protein modified form]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of and results in increased activity of CASP3 protein
CTD PMID:21209419 PMID:34897970
NCBI chr16:45,662,910...45,681,171
G
Casp9 caspase 9
multiple interactions
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP9 protein modified form]]
CTD PMID:34897970
NCBI chr 5:154,108,872...154,126,628
G
Ccnd1 cyclin D1
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of CCND1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of CCND1 mRNA]
CTD PMID:19160421
NCBI chr 1:200,089,002...200,098,524
G
Cdh1 cadherin 1
multiple interactions
ISO [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester co-treated with 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one] inhibits the reaction [polyhexamethyleneguanidine results in decreased expression of CDH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased secretion of CDH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium results in increased cleavage of CDH1 protein]
CTD PMID:18791180 PMID:31348943
NCBI chr19:34,492,371...34,561,775
G
Cdh2 cadherin 2
multiple interactions
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]
CTD PMID:23876460
NCBI chr18:7,776,704...7,990,934
G
Csf1 colony stimulating factor 1
multiple interactions
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of CSF1 mRNA]
CTD PMID:24223152
NCBI chr 2:195,377,215...195,396,608
G
Eno2 enolase 2
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of ENO2 mRNA]
CTD PMID:24929042
NCBI chr 4:157,572,085...157,580,971
G
Flt1 Fms related receptor tyrosine kinase 1
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of FLT1 protein]
CTD PMID:21843347
NCBI chr12:7,296,899...7,468,626
G
Foxo3 forkhead box O3
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [Hydrogen Peroxide results in increased expression of FOXO3 protein]
CTD PMID:25108166
NCBI chr20:45,669,708...45,764,606
G
Hes1 hes family bHLH transcription factor 1
multiple interactions
ISO EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HES1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HES1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Hydrogen Peroxide results in increased expression of HES1 protein]
CTD
PMID:19160421 PMID:24223152 PMID:25005833 PMID:25108166 PMID:32041402 PMID:36988346 More...
NCBI chr11:70,705,763...70,708,176
G
Hey1 hes-related family bHLH transcription factor with YRPW motif 1
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA]
CTD PMID:19160421
NCBI chr 2:93,096,605...93,100,316
G
Hey2 hes-related family bHLH transcription factor with YRPW motif 2
multiple interactions
ISO EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY2 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA]
CTD PMID:19160421 PMID:32041402
NCBI chr 1:26,822,131...26,832,218
G
Hif1a hypoxia inducible factor 1 subunit alpha
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein]
CTD PMID:25108166
NCBI chr 6:92,624,059...92,669,262
G
Hmgb1 high mobility group box 1
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of HMGB1 protein]
CTD PMID:21843347
NCBI chr12:5,972,950...5,979,658
G
Il10 interleukin 10
multiple interactions
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL10 mRNA]
CTD PMID:24223152
NCBI chr13:42,472,625...42,477,308
G
Il1b interleukin 1 beta
multiple interactions
ISO EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL1B protein]
CTD PMID:21843347 PMID:24223152 PMID:36988346
NCBI chr 3:116,577,005...116,583,386
G
Il6 interleukin 6
multiple interactions
EXP ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL6 mRNA]
CTD PMID:21843347 PMID:24223152
NCBI chr 4:5,214,602...5,219,178
G
Itgam integrin subunit alpha M
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of ITGAM protein]
CTD PMID:28130038
NCBI chr 1:182,659,047...182,709,501
G
Ivl involucrin
decreases expression
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of IVL mRNA; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of IVL protein
CTD PMID:18633435
NCBI chr 2:178,146,694...178,160,807
G
Jag1 jagged canonical Notch ligand 1
decreases expression
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of JAG1 mRNA; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of JAG1 protein
CTD PMID:18633435
NCBI chr 3:124,406,783...124,442,220
G
Krt1 keratin 1
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [U 0126 results in increased expression of KRT1 mRNA]
CTD PMID:18633435 PMID:23566955
NCBI chr 7:132,976,618...132,981,844
G
Krt10 keratin 10
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT10 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [U 0126 results in increased expression of KRT10 mRNA]
CTD PMID:18633435 PMID:23566955
NCBI chr10:84,338,695...84,343,279
G
Lgr5 leucine rich repeat containing G protein coupled receptor 5
multiple interactions
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [tetrabromobisphenol A results in increased expression of LGR5 mRNA]
CTD PMID:32041402
NCBI chr 7:51,087,059...51,221,882
G
Map2 microtubule-associated protein 2
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of MAP2 mRNA]
CTD PMID:24929042
NCBI chr 9:67,723,422...67,981,886
G
Mdm2 MDM2 proto-oncogene
multiple interactions
ISO Hydrogen Peroxide inhibits the reaction [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of MDM2 protein]
CTD PMID:25005833
NCBI chr 7:53,290,660...53,315,205
G
Mir141 microRNA 141
multiple interactions
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in decreased expression of BCL2 protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP3 protein modified form]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP9 protein modified form]]
CTD PMID:34897970
NCBI chr 4:157,523,239...157,523,332
G
Myd88 MYD88, innate immune signal transduction adaptor
multiple interactions
ISO EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 protein]
CTD PMID:24223152
NCBI chr 8:119,074,439...119,078,508
G
Nos2 nitric oxide synthase 2
multiple interactions
ISO EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of NOS2 protein]
CTD PMID:24223152
NCBI chr10:63,815,308...63,851,208
G
Notch1 notch receptor 1
multiple interactions
ISO EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Hydrogen Peroxide results in increased cleavage of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [phenethyl isothiocyanate results in increased cleavage of and results in increased activity of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased cleavage of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [polyhexamethyleneguanidine results in increased cleavage of NOTCH1 protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased cleavage of and results in decreased activity of NOTCH1 protein
CTD
PMID:18633435 PMID:22039516 PMID:22115781 PMID:24223152 PMID:25108166 PMID:25118938 PMID:28130038 PMID:31348943 PMID:36988346 More...
NCBI chr 3:9,277,955...9,323,531
G
Notch2 notch receptor 2
multiple interactions
ISO EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased cleavage of and results in decreased activity of NOTCH2 protein
CTD PMID:22039516 PMID:36988346
NCBI chr 2:185,610,594...185,744,088
G
Notch3 notch receptor 3
decreases expression
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of NOTCH3 protein
CTD PMID:36988346
NCBI chr 7:11,132,984...11,184,025
G
Notch4 notch receptor 4
decreases expression
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of NOTCH4 protein
CTD PMID:36988346
NCBI chr20:4,160,362...4,184,466
G
Numb NUMB, endocytic adaptor protein
increases expression
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of NUMB protein
CTD PMID:25005833
NCBI chr 6:103,431,400...103,553,422
G
Pml PML nuclear body scaffold
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]
CTD PMID:28130038
NCBI chr 8:58,627,347...58,661,927
G
Ppara peroxisome proliferator activated receptor alpha
increases expression
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of PPARA protein
CTD PMID:36988346
NCBI chr 7:116,832,405...116,900,878
G
Ptgs2 prostaglandin-endoperoxide synthase 2
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium results in increased expression of PTGS2 mRNA]
CTD PMID:18791180
NCBI chr13:62,163,936...62,172,193
G
Rara retinoic acid receptor, alpha
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]
CTD PMID:28130038
NCBI chr10:83,883,490...83,928,932
G
Rbpj recombination signal binding protein for immunoglobulin kappa J region
multiple interactions
EXP ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of RBPJ mRNA]
CTD PMID:22302987 PMID:24223152
NCBI chr14:57,338,493...57,523,330
G
Rela RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency affects the localization of RELA protein modified form]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of RELA protein]
CTD PMID:24223152
NCBI chr 1:202,925,001...202,935,484
G
Tgfb1 transforming growth factor, beta 1
multiple interactions
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TGFB1 mRNA]
CTD PMID:24223152
NCBI chr 1:81,196,532...81,212,848
G
Tlr4 toll-like receptor 4
multiple interactions
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TLR4 mRNA]
CTD PMID:24223152
NCBI chr 5:80,145,867...80,159,501
G
Tnf tumor necrosis factor
multiple interactions
ISO EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TNF protein]
CTD PMID:24223152
NCBI chr20:3,622,011...3,624,629
G
Tp53 tumor protein p53
decreases expression
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of TP53 protein
CTD PMID:25005833
NCBI chr10:54,300,070...54,311,525
G
Traf6 TNF receptor associated factor 6
multiple interactions
ISO EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TRAF6 protein]
CTD PMID:24223152
NCBI chr 3:87,963,517...87,988,316
G
Tubb3 tubulin, beta 3 class III
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of TUBB3 mRNA]
CTD PMID:24929042
NCBI chr19:51,457,187...51,466,243
G
Vegfa vascular endothelial growth factor A
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of VEGFA protein]
CTD PMID:21843347
NCBI chr 9:14,955,300...14,970,641
G
Vil1 villin 1
multiple interactions
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [tetrabromobisphenol A results in increased expression of VIL1 mRNA]
CTD PMID:32041402
NCBI chr 9:75,991,141...76,018,860
G
Abca1 ATP binding cassette subfamily A member 1
increases expression
ISO fenpyroximate results in increased expression of ABCA1 mRNA
CTD PMID:33512557
NCBI chr 5:67,678,267...67,801,162
G
Ache acetylcholinesterase
decreases activity
EXP fenpyroximate results in decreased activity of ACHE protein
CTD PMID:35580743
NCBI chr12:19,406,133...19,413,713
G
Akr1b1 aldo-keto reductase family 1 member B1
decreases expression
ISO fenpyroximate results in decreased expression of AKR1B1 mRNA
CTD PMID:33512557
NCBI chr 4:62,932,033...62,946,126
G
Akr7a2 aldo-keto reductase family 7, member A2
decreases expression
ISO fenpyroximate results in decreased expression of AKR7A2 mRNA
CTD PMID:33512557
NCBI chr 5:151,552,375...151,560,914
G
Akt1 AKT serine/threonine kinase 1
decreases expression
ISO fenpyroximate results in decreased expression of AKT1 mRNA
CTD PMID:33512557
NCBI chr 6:131,713,716...131,735,319
G
Aldh9a1 aldehyde dehydrogenase 9 family, member A1
decreases expression
ISO fenpyroximate results in decreased expression of ALDH9A1 mRNA
CTD PMID:33512557
NCBI chr13:79,505,738...79,522,539
G
Amer1 APC membrane recruitment protein 1
decreases expression
ISO fenpyroximate results in decreased expression of AMER1 mRNA
CTD PMID:33512557
NCBI chr X:60,300,595...60,316,480
G
Ano10 anoctamin 10
decreases expression
ISO fenpyroximate results in decreased expression of ANO10 mRNA
CTD PMID:33512557
NCBI chr 8:121,841,664...121,960,739
G
Ap3m1 adaptor related protein complex 3 subunit mu 1
decreases expression
ISO fenpyroximate results in decreased expression of AP3M1 mRNA
CTD PMID:33512557
NCBI chr15:3,246,616...3,264,846
G
Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1
increases expression
ISO fenpyroximate results in increased expression of APEX1 mRNA
CTD PMID:33512557
NCBI chr15:24,144,595...24,146,785
G
Arg1 arginase 1
decreases expression
ISO fenpyroximate results in decreased expression of ARG1 mRNA
CTD PMID:32194361
NCBI chr 1:20,475,878...20,488,422
G
Arhgap9 Rho GTPase activating protein 9
increases expression
ISO fenpyroximate results in increased expression of ARHGAP9 mRNA
CTD PMID:33512557
NCBI chr 7:63,148,573...63,157,025
G
Arrdc4 arrestin domain containing 4
decreases expression
ISO fenpyroximate results in decreased expression of ARRDC4 mRNA
CTD PMID:33512557
NCBI chr 1:122,369,355...122,383,351
G
Asns asparagine synthetase (glutamine-hydrolyzing)
increases expression
ISO fenpyroximate results in increased expression of ASNS mRNA
CTD PMID:33512557
NCBI chr 4:35,784,995...35,803,474
G
Ass1 argininosuccinate synthase 1
increases expression
ISO fenpyroximate results in increased expression of ASS1 mRNA
CTD PMID:33512557
NCBI chr 3:14,747,355...14,796,909
G
Atf4 activating transcription factor 4
increases expression
ISO fenpyroximate results in increased expression of ATF4 mRNA
CTD PMID:33512557
NCBI chr 7:111,804,135...111,806,457
G
Atf5 activating transcription factor 5
increases expression
ISO fenpyroximate results in increased expression of ATF5 mRNA
CTD PMID:33512557
NCBI chr 1:95,295,602...95,299,755
G
Atmin ATM interactor
decreases expression
ISO fenpyroximate results in decreased expression of ATMIN mRNA
CTD PMID:33512557
NCBI chr19:44,996,506...45,013,606
G
Atp5f1b ATP synthase F1 subunit beta
decreases expression
ISO fenpyroximate results in decreased expression of ATP5F1B mRNA
CTD PMID:33512557
NCBI chr 7:515,454...521,858
G
Atp5f1c ATP synthase F1 subunit gamma
decreases expression
ISO fenpyroximate results in decreased expression of ATP5F1C mRNA
CTD PMID:33512557
NCBI chr17:68,423,927...68,446,169
G
Atp6v1b2 ATPase H+ transporting V1 subunit B2
decreases expression
ISO fenpyroximate results in decreased expression of ATP6V1B2 mRNA
CTD PMID:33512557
NCBI chr16:20,617,515...20,641,651
G
Aurka aurora kinase A
increases expression
ISO fenpyroximate results in increased expression of AURKA mRNA
CTD PMID:33512557
NCBI chr 3:161,128,309...161,144,524
G
B2m beta-2 microglobulin
increases expression
ISO fenpyroximate results in increased expression of B2M mRNA
CTD PMID:33512557
NCBI chr 3:109,095,740...109,101,764
G
B3galt6 Beta-1,3-galactosyltransferase 6
decreases expression
ISO fenpyroximate results in decreased expression of B3GALT6 mRNA
CTD PMID:33512557
NCBI chr 5:166,584,202...166,586,338
G
Bax BCL2 associated X, apoptosis regulator
increases expression
ISO fenpyroximate results in increased expression of BAX mRNA
CTD PMID:36933581
NCBI chr 1:95,940,001...95,945,407
G
Bcl2 BCL2, apoptosis regulator
decreases expression
ISO fenpyroximate results in decreased expression of BCL2 mRNA
CTD PMID:36933581
NCBI chr13:22,689,783...22,853,920
G
Bcl2l13 Bcl2-like 13
decreases expression
ISO fenpyroximate results in decreased expression of BCL2L13 mRNA
CTD PMID:33512557
NCBI chr 4:154,056,116...154,112,890
G
Birc5 baculoviral IAP repeat-containing 5
increases expression
ISO fenpyroximate results in increased expression of BIRC5 mRNA
CTD PMID:33512557
NCBI chr10:103,072,530...103,081,382
G
Bmf Bcl2 modifying factor
decreases expression
ISO fenpyroximate results in decreased expression of BMF mRNA
CTD PMID:33512557
NCBI chr 3:105,499,534...105,520,159
G
Bphl biphenyl hydrolase like
decreases expression
ISO fenpyroximate results in decreased expression of BPHL mRNA
CTD PMID:33512557
NCBI chr17:30,800,939...30,837,277
G
Bzw1 basic leucine zipper and W2 domains 1
decreases expression
ISO fenpyroximate results in decreased expression of BZW1 mRNA
CTD PMID:33512557
NCBI chr 9:59,930,672...59,944,468
G
C2cd5 C2 calcium-dependent domain containing 5
decreases expression
ISO fenpyroximate results in decreased expression of C2CD5 mRNA
CTD PMID:33512557
NCBI chr 4:175,969,544...176,055,597
G
Canx calnexin
increases expression
ISO fenpyroximate results in increased expression of CANX mRNA
CTD PMID:33512557
NCBI chr10:34,623,865...34,656,866
G
Cars1 cysteinyl-tRNA synthetase 1
increases expression
ISO fenpyroximate results in increased expression of CARS1 mRNA
CTD PMID:33512557
NCBI chr 1:198,753,689...198,796,016
G
Casp3 caspase 3
increases activity
ISO fenpyroximate results in increased activity of CASP3 protein
CTD PMID:35580743 PMID:36933581
NCBI chr16:45,662,910...45,681,171
G
Casp9 caspase 9
increases activity
ISO fenpyroximate results in increased activity of CASP9 protein
CTD PMID:36933581
NCBI chr 5:154,108,872...154,126,628
G
Cat catalase
increases activity
ISO EXP fenpyroximate results in increased activity of CAT protein
CTD PMID:35580743 PMID:36933581
NCBI chr 3:89,842,393...89,874,577
G
Cbr1 carbonyl reductase 1
decreases expression
ISO fenpyroximate results in decreased expression of CBR1 mRNA
CTD PMID:33512557
NCBI chr11:32,860,571...32,862,981
G
Cbx4 chromobox 4
increases expression
ISO fenpyroximate results in increased expression of CBX4 mRNA
CTD PMID:33512557
NCBI chr10:104,337,140...104,343,210
G
Ccnb1 cyclin B1
increases expression
ISO fenpyroximate results in increased expression of CCNB1 mRNA
CTD PMID:33512557
NCBI chr 2:31,912,190...31,921,163
G
Ccnb2 cyclin B2
increases expression
ISO fenpyroximate results in increased expression of CCNB2 mRNA
CTD PMID:33512557
NCBI chr 8:71,087,594...71,100,794
G
Cd24 CD24 molecule
decreases expression
ISO fenpyroximate results in decreased expression of CD24 mRNA
CTD PMID:33512557
NCBI chr20:47,074,353...47,079,662
G
Cdh10 cadherin 10
decreases expression
ISO fenpyroximate results in decreased expression of CDH10 mRNA
CTD PMID:33512557
NCBI chr 2:68,628,623...68,850,995
G
Cdh2 cadherin 2
decreases expression
ISO fenpyroximate results in decreased expression of CDH2 mRNA
CTD PMID:33512557
NCBI chr18:7,776,704...7,990,934
G
Cdk1 cyclin-dependent kinase 1
increases expression
ISO fenpyroximate results in increased expression of CDK1 mRNA
CTD PMID:33512557
NCBI chr20:19,266,226...19,281,417
G
Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1
decreases expression
ISO fenpyroximate results in decreased expression of CDK5R1 mRNA
CTD PMID:33512557
NCBI chr10:65,484,266...65,485,467
G
Cdk6 cyclin-dependent kinase 6
increases expression
ISO fenpyroximate results in increased expression of CDK6 mRNA
CTD PMID:33512557
NCBI chr 4:30,637,650...30,829,688
G
Cdkn3 cyclin-dependent kinase inhibitor 3
increases expression
ISO fenpyroximate results in increased expression of CDKN3 mRNA
CTD PMID:33512557
NCBI chr15:20,022,522...20,033,948
G
Cebpb CCAAT/enhancer binding protein beta
increases expression
ISO fenpyroximate results in increased expression of CEBPB mRNA
CTD PMID:33512557
NCBI chr 3:156,398,035...156,399,466
G
Cel carboxyl ester lipase
decreases expression
ISO fenpyroximate results in decreased expression of CEL mRNA
CTD PMID:33512557
NCBI chr 3:11,883,532...11,891,035
G
Cfl2 cofilin 2
decreases expression
ISO fenpyroximate results in decreased expression of CFL2 mRNA
CTD PMID:33512557
NCBI chr 6:72,355,664...72,359,709
G
Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
increases expression
ISO fenpyroximate results in increased expression of CHAC1 mRNA
CTD PMID:33512557
NCBI chr 3:106,342,302...106,345,526
G
Chek1 checkpoint kinase 1
increases expression
ISO fenpyroximate results in increased expression of CHEK1 mRNA
CTD PMID:33512557
NCBI chr 8:36,420,565...36,443,477
G
Chka choline kinase alpha
increases expression
ISO fenpyroximate results in increased expression of CHKA mRNA
CTD PMID:33512557
NCBI chr 1:201,076,804...201,125,517
G
Cks1b CDC28 protein kinase regulatory subunit 1B
increases expression
ISO fenpyroximate results in increased expression of CKS1B mRNA
CTD PMID:33512557
NCBI chr 2:174,833,025...174,837,614
G
Cks2 CDC28 protein kinase regulatory subunit 2
increases expression
ISO fenpyroximate results in increased expression of CKS2 mRNA
CTD PMID:33512557
NCBI chr17:13,570,611...13,575,770
G
Clic4 chloride intracellular channel 4
increases expression
ISO fenpyroximate results in increased expression of CLIC4 mRNA
CTD PMID:33512557
NCBI chr 5:147,453,702...147,513,455
G
Cnpy3 canopy FGF signaling regulator 3
increases expression
ISO fenpyroximate results in increased expression of CNPY3 mRNA
CTD PMID:33512557
NCBI chr 9:14,233,478...14,247,847
G
Cntn1 contactin 1
increases expression
ISO fenpyroximate results in increased expression of CNTN1 mRNA
CTD PMID:33512557
NCBI chr 7:123,263,146...123,560,896
G
Coa6 cytochrome c oxidase assembly factor 6
increases expression
ISO fenpyroximate results in increased expression of COA6 mRNA
CTD PMID:33512557
NCBI chr19:54,395,746...54,398,348
G
Col16a1 collagen type XVI alpha 1 chain
increases expression
ISO fenpyroximate results in increased expression of COL16A1 mRNA
CTD PMID:33512557
NCBI chr 5:142,388,376...142,442,825
G
Cops5 COP9 signalosome subunit 5
decreases expression
ISO fenpyroximate results in decreased expression of COPS5 mRNA
CTD PMID:33512557
NCBI chr 5:9,192,233...9,210,498
G
Crebrf CREB3 regulatory factor
increases expression
ISO fenpyroximate results in increased expression of CREBRF mRNA
CTD PMID:33512557
NCBI chr10:16,399,170...16,479,650
G
Creg1 cellular repressor of E1A-stimulated genes 1
increases expression
ISO fenpyroximate results in increased expression of CREG1 mRNA
CTD PMID:33512557
NCBI chr13:78,019,814...78,032,310
G
Creld2 cysteine-rich with EGF-like domains 2
increases expression
ISO fenpyroximate results in increased expression of CRELD2 mRNA
CTD PMID:33512557
NCBI chr 7:119,909,626...119,916,556
G
Crtap cartilage associated protein
increases expression
ISO fenpyroximate results in increased expression of CRTAP mRNA
CTD PMID:33512557
NCBI chr 8:114,047,929...114,067,636
G
Ctnnal1 catenin alpha-like 1
increases expression
ISO fenpyroximate results in increased expression of CTNNAL1 mRNA
CTD PMID:33512557
NCBI chr 5:71,514,340...71,569,431
G
Ctnnd1 catenin delta 1
decreases expression
ISO fenpyroximate results in decreased expression of CTNND1 mRNA
CTD PMID:33512557
NCBI chr 3:69,683,328...69,734,550
G
Ctps1 CTP synthase 1
decreases expression
ISO fenpyroximate results in decreased expression of CTPS1 mRNA
CTD PMID:33512557
NCBI chr 5:134,125,022...134,154,155
G
Cttn cortactin
decreases expression
ISO fenpyroximate results in decreased expression of CTTN mRNA
CTD PMID:33512557
NCBI chr 1:199,599,710...199,635,254
G
Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO fenpyroximate results in increased expression of CYP1A1 mRNA
CTD PMID:32194361
NCBI chr 8:58,096,021...58,102,130
G
Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6
decreases expression
ISO fenpyroximate results in decreased expression of CYP2C19 protein
CTD PMID:32194361
NCBI chr 1:237,938,521...237,976,238
G
Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9
increases expression
ISO fenpyroximate results in increased expression of CYP3A5 mRNA
CTD PMID:34642769
NCBI chr12:16,806,222...16,846,428
G
Cyp7a1 cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO fenpyroximate results in decreased expression of CYP7A1 mRNA; fenpyroximate results in decreased expression of CYP7A1 protein
CTD PMID:32194361
NCBI chr 5:19,376,979...19,386,676
G
Daam1 dishevelled associated activator of morphogenesis 1
decreases expression
ISO fenpyroximate results in decreased expression of DAAM1 mRNA
CTD PMID:33512557
NCBI chr 6:90,389,544...90,550,114
G
Daxx death-domain associated protein
decreases expression
ISO fenpyroximate results in decreased expression of DAXX mRNA
CTD PMID:33512557
NCBI chr20:4,970,090...4,976,145
G
Dck deoxycytidine kinase
decreases expression
ISO fenpyroximate results in decreased expression of DCK mRNA
CTD PMID:33512557
NCBI chr14:19,305,218...19,326,247
G
Ddc dopa decarboxylase
decreases expression
ISO fenpyroximate results in decreased expression of DDC mRNA
CTD PMID:34642769
NCBI chr14:86,378,685...86,469,189
G
Ddit3 DNA-damage inducible transcript 3
increases expression
ISO fenpyroximate results in increased expression of DDIT3 mRNA
CTD PMID:33512557
NCBI chr 7:63,115,645...63,121,203
G
Depdc1b DEP domain containing 1B
increases expression
ISO fenpyroximate results in increased expression of DEPDC1B mRNA
CTD PMID:33512557
NCBI chr 2:39,891,163...39,963,779
G
Dffb DNA fragmentation factor subunit beta
decreases expression
ISO fenpyroximate results in decreased expression of DFFB mRNA
CTD PMID:33512557
NCBI chr 5:164,522,446...164,534,733
G
Dlgap5 DLG associated protein 5
increases expression
ISO fenpyroximate results in increased expression of DLGAP5 mRNA
CTD PMID:33512557
NCBI chr15:20,633,964...20,664,569
G
Dnajb14 DnaJ heat shock protein family (Hsp40) member B14
increases expression
ISO fenpyroximate results in increased expression of DNAJB14 mRNA
CTD PMID:33512557
NCBI chr 2:226,358,988...226,409,461
G
Dnttip2 deoxynucleotidyltransferase, terminal, interacting protein 2
decreases expression
ISO fenpyroximate results in decreased expression of DNTTIP2 mRNA
CTD PMID:33512557
NCBI chr 2:210,374,321...210,386,366
G
Drd2 dopamine receptor D2
decreases expression
ISO fenpyroximate results in decreased expression of DRD2 mRNA
CTD PMID:33512557
NCBI chr 8:49,708,927...49,772,876
G
Dusp4 dual specificity phosphatase 4
increases expression
ISO fenpyroximate results in increased expression of DUSP4 mRNA
CTD PMID:33512557
NCBI chr16:57,376,659...57,398,161
G
Eef1g eukaryotic translation elongation factor 1 gamma
decreases expression
ISO fenpyroximate results in decreased expression of EEF1G mRNA
CTD PMID:33512557
NCBI chr 1:205,860,713...205,871,319
G
Egr1 early growth response 1
increases expression
ISO fenpyroximate results in increased expression of EGR1 mRNA
CTD PMID:33512557
NCBI chr18:26,462,967...26,466,766
G
Eif2s2 eukaryotic translation initiation factor 2 subunit beta
increases expression
ISO fenpyroximate results in increased expression of EIF2S2 mRNA
CTD PMID:33512557
NCBI chr 3:143,374,652...143,395,460
G
Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1
increases expression
ISO fenpyroximate results in increased expression of EIF4EBP1 mRNA
CTD PMID:33512557
NCBI chr16:64,792,595...64,805,984
G
Elmod1 ELMO domain containing 1
decreases expression
ISO fenpyroximate results in decreased expression of ELMOD1 mRNA
CTD PMID:33512557
NCBI chr 8:54,298,363...54,355,348
G
Ep300 E1A binding protein p300
decreases expression
ISO fenpyroximate results in decreased expression of EP300 mRNA
CTD PMID:33512557
NCBI chr 7:113,108,476...113,178,529
G
Ephb2 Eph receptor B2
decreases expression
ISO fenpyroximate results in decreased expression of EPHB2 mRNA
CTD PMID:33512557
NCBI chr 5:148,889,574...149,077,027
G
Ero1a endoplasmic reticulum oxidoreductase 1 alpha
increases expression
ISO fenpyroximate results in increased expression of ERO1A mRNA
CTD PMID:33512557
NCBI chr15:18,495,037...18,530,440
G
Ero1b endoplasmic reticulum oxidoreductase 1 beta
increases expression
ISO fenpyroximate results in increased expression of ERO1B mRNA
CTD PMID:33512557
NCBI chr17:85,861,086...86,003,244
G
Esr2 estrogen receptor 2
multiple interactions
ISO fenpyroximate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]
CTD PMID:30818834
NCBI chr 6:94,858,438...94,909,630
G
Esrra estrogen related receptor, alpha
multiple interactions
ISO fenpyroximate inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; fenpyroximate inhibits the reaction [XCT790 results in decreased activity of ESRRA protein]
CTD PMID:30818834
NCBI chr 1:204,104,100...204,114,182
G
Exosc4 exosome component 4
decreases expression
ISO fenpyroximate results in decreased expression of EXOSC4 mRNA
CTD PMID:33512557
NCBI chr 7:108,047,831...108,050,573
G
Exosc8 exosome component 8
increases expression
ISO fenpyroximate results in increased expression of EXOSC8 mRNA
CTD PMID:33512557
NCBI chr 2:138,930,405...138,937,009
G
Fam72a family with sequence similarity 72, member A
increases expression
ISO fenpyroximate results in increased expression of FAM72A mRNA
CTD PMID:33512557
NCBI chr13:42,967,701...42,979,083
G
Fbl fibrillarin
increases expression
ISO fenpyroximate results in increased expression of FBL mRNA
CTD PMID:33512557
NCBI chr 1:83,469,832...83,478,932
G
Fbxo7 F-box protein 7
decreases expression
ISO fenpyroximate results in decreased expression of FBXO7 mRNA
CTD PMID:33512557
NCBI chr 7:17,809,224...17,837,549
G
Fgf2 fibroblast growth factor 2
increases expression
ISO fenpyroximate results in increased expression of FGF2 mRNA
CTD PMID:33512557
NCBI chr 2:120,236,328...120,290,673
G
Fth1 ferritin heavy chain 1
increases expression
ISO fenpyroximate results in increased expression of FTH1 mRNA
CTD PMID:33512557
NCBI chr 1:206,627,142...206,629,430
G
Ftl1 ferritin light chain 1
increases expression
ISO fenpyroximate results in increased expression of FTL mRNA
CTD PMID:33512557
NCBI chr 1:95,936,387...95,938,234
G
G6pc1 glucose-6-phosphatase catalytic subunit 1
decreases expression
ISO fenpyroximate results in decreased expression of G6PC1 mRNA
CTD PMID:32194361
NCBI chr10:86,307,400...86,318,766
G
G6pd glucose-6-phosphate dehydrogenase
decreases expression
ISO fenpyroximate results in decreased expression of G6PD mRNA
CTD PMID:33512557
NCBI chr X:152,201,081...152,220,863
G
Gadd45b growth arrest and DNA-damage-inducible, beta
increases expression
ISO fenpyroximate results in increased expression of GADD45B mRNA
CTD PMID:33512557
NCBI chr 7:8,778,004...8,780,306
G
Gadd45g growth arrest and DNA-damage-inducible, gamma
increases expression
ISO fenpyroximate results in increased expression of GADD45G mRNA
CTD PMID:33512557
NCBI chr17:13,376,842...13,378,587
G
Gap43 growth associated protein 43
decreases expression
ISO fenpyroximate results in decreased expression of GAP43 mRNA
CTD PMID:33512557
NCBI chr11:58,376,371...58,470,047
G
Gclm glutamate cysteine ligase, modifier subunit
increases expression
ISO fenpyroximate results in increased expression of GCLM mRNA
CTD PMID:33512557
NCBI chr 2:210,347,482...210,367,537
G
Gdf15 growth differentiation factor 15
increases expression
ISO fenpyroximate results in increased expression of GDF15 mRNA
CTD PMID:33512557
NCBI chr16:18,804,457...18,808,043
G
Gfus GDP-L-fucose synthase
increases expression
ISO fenpyroximate results in increased expression of GFUS mRNA
CTD PMID:33512557
NCBI chr 7:107,612,087...107,617,005
G
Gldc glycine decarboxylase
decreases expression
ISO fenpyroximate results in decreased expression of GLDC mRNA
CTD PMID:33512557
NCBI chr 1:227,883,249...227,962,119
G
Gli3 GLI family zinc finger 3
decreases expression
ISO fenpyroximate results in decreased expression of GLI3 mRNA
CTD PMID:33512557
NCBI chr17:49,438,567...49,709,712
G
Glrx glutaredoxin
decreases expression
ISO fenpyroximate results in decreased expression of GLRX mRNA
CTD PMID:33512557
NCBI chr 2:5,341,873...5,351,686
G
Gnai2 G protein subunit alpha i2
decreases expression
ISO fenpyroximate results in decreased expression of GNAI2 mRNA
CTD PMID:33512557
NCBI chr 8:108,288,401...108,309,009
G
Grb10 growth factor receptor bound protein 10
increases expression
ISO fenpyroximate results in increased expression of GRB10 mRNA
CTD PMID:33512557
NCBI chr14:86,495,051...86,602,800
G
Grm4 glutamate metabotropic receptor 4
decreases expression
ISO fenpyroximate results in decreased expression of GRM4 mRNA
CTD PMID:33512557
NCBI chr20:5,484,172...5,572,821
G
Gstm2 glutathione S-transferase mu 2
decreases expression
ISO fenpyroximate results in decreased expression of GSTM2 mRNA
CTD PMID:33512557
NCBI chr 2:195,624,015...195,628,774
G
H1f2 H1.2 linker histone, cluster member
increases expression
ISO fenpyroximate results in increased expression of H1-2 mRNA
CTD PMID:33512557
NCBI chr17:41,391,106...41,392,597
G
H2bc3 H2B clustered histone 3
increases expression
ISO fenpyroximate results in increased expression of H2BC3 mRNA
CTD PMID:33512557
NCBI chr17:41,380,056...41,380,686
G
H2bc9 H2B clustered histone 9
increases expression
ISO fenpyroximate results in increased expression of H2BC9 mRNA
CTD PMID:33512557
NCBI chr17:42,470,593...42,478,590
G
Hapstr1 HUWE1 associated protein modifying stress responses
increases expression
ISO fenpyroximate results in increased expression of HAPSTR1 mRNA
CTD PMID:33512557
NCBI chr10:6,746,037...6,774,992
G
Hcst hematopoietic cell signal transducer
increases expression
ISO fenpyroximate results in increased expression of HCST mRNA
CTD PMID:33512557
NCBI chr 1:85,676,976...85,679,083
G
Hdac2 histone deacetylase 2
decreases expression
ISO fenpyroximate results in decreased expression of HDAC2 mRNA
CTD PMID:33512557
NCBI chr20:40,548,244...40,571,609
G
Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1
increases expression
ISO fenpyroximate results in increased expression of HERPUD1 mRNA
CTD PMID:33512557
NCBI chr19:10,598,411...10,609,002
G
Hes1 hes family bHLH transcription factor 1
increases expression
ISO fenpyroximate results in increased expression of HES1 mRNA
CTD PMID:33512557
NCBI chr11:70,705,763...70,708,176
G
Hist1h2af histone cluster 1 H2A family member F
increases expression
ISO fenpyroximate results in increased expression of H2AC8 mRNA
CTD PMID:33512557
NCBI chr17:41,379,404...41,379,796
G
Hist1h2ah histone cluster 1 H2A family member H
increases expression
ISO fenpyroximate results in increased expression of H2AC11 mRNA
CTD PMID:33512557
NCBI chr17:41,384,521...41,385,018
G
Hist1h2al1 histone cluster 1 H2A family like 1
increases expression
ISO fenpyroximate results in increased expression of H2AC6 mRNA
CTD PMID:33512557
NCBI chr17:42,707,954...42,708,420
G
Hist1h2bd histone cluster 1 H2B family member D
increases expression
ISO fenpyroximate results in increased expression of H2BC5 mRNA
CTD PMID:33512557
NCBI chr17:42,792,887...42,793,268
G
Hmox1 heme oxygenase 1
increases expression
ISO fenpyroximate results in increased expression of HMOX1 mRNA
CTD PMID:33512557
NCBI chr19:13,466,287...13,474,082
G
Hnrnpm heterogeneous nuclear ribonucleoprotein M
decreases expression
ISO fenpyroximate results in decreased expression of HNRNPM mRNA
CTD PMID:33512557
NCBI chr 7:14,438,703...14,476,781
G
Hsp90b1 heat shock protein 90 beta family member 1
increases expression
ISO fenpyroximate results in increased expression of HSP90B1 mRNA
CTD PMID:33512557
NCBI chr 7:21,110,431...21,124,762
G
Hspa1b heat shock protein family A (Hsp70) member 1B
increases expression
ISO fenpyroximate results in increased expression of HSPA1B mRNA
CTD PMID:33512557
NCBI chr20:3,855,104...3,859,148
G
Hspe1 heat shock protein family E (Hsp10) member 1
increases expression
ISO fenpyroximate results in increased expression of HSPE1 mRNA
CTD PMID:33512557
NCBI chr 9:56,589,912...56,593,000
G
Htatsf1 HIV-1 Tat specific factor 1
decreases expression
ISO fenpyroximate results in decreased expression of HTATSF1 mRNA
CTD PMID:33512557
NCBI chr X:134,935,426...134,949,607
G
Id1 inhibitor of DNA binding 1
decreases expression
ISO fenpyroximate results in decreased expression of ID1 mRNA
CTD PMID:33512557
NCBI chr 3:141,210,666...141,212,420
G
Id2 inhibitor of DNA binding 2
increases expression
ISO fenpyroximate results in increased expression of ID2 mRNA
CTD PMID:33512557
NCBI chr 6:41,740,556...41,742,393
G
Ifrd1 interferon-related developmental regulator 1
increases expression
ISO fenpyroximate results in increased expression of IFRD1 mRNA
CTD PMID:33512557
NCBI chr 6:57,269,395...57,317,833
G
Igf1r insulin-like growth factor 1 receptor
decreases expression
ISO fenpyroximate results in decreased expression of IGF1R mRNA
CTD PMID:33512557
NCBI chr 1:121,549,831...121,838,548
G
Igfbp2 insulin-like growth factor binding protein 2
decreases expression
ISO fenpyroximate results in decreased expression of IGFBP2 mRNA
CTD PMID:33512557
NCBI chr 9:74,415,574...74,442,945
G
Ina internexin neuronal intermediate filament protein, alpha
decreases expression
ISO fenpyroximate results in decreased expression of INA mRNA
CTD PMID:33512557
NCBI chr 1:245,896,775...245,908,330
G
Ipo5 importin 5
increases expression
ISO fenpyroximate results in increased expression of IPO5 mRNA
CTD PMID:33512557
NCBI chr15:97,990,755...98,041,074
G
Itpr2 inositol 1,4,5-trisphosphate receptor, type 2
decreases expression
ISO fenpyroximate results in decreased expression of ITPR2 mRNA
CTD PMID:33512557
NCBI chr 4:179,028,594...179,434,657
G
Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase
increases expression
ISO fenpyroximate results in increased expression of JMJD6 mRNA
CTD PMID:33512557
NCBI chr10:102,041,131...102,047,182
G
Kdm3a lysine demethylase 3A
decreases expression
ISO fenpyroximate results in decreased expression of KDM3A mRNA
CTD PMID:33512557
NCBI chr 4:103,630,907...103,675,073
G
Kdm5b lysine demethylase 5B
decreases expression
ISO fenpyroximate results in decreased expression of KDM5B mRNA
CTD PMID:33512557
NCBI chr13:46,001,589...46,073,868
G
Kif15 kinesin family member 15
increases expression
ISO fenpyroximate results in increased expression of KIF15 mRNA
CTD PMID:33512557
NCBI chr 8:122,601,888...122,672,750
G
Kif20a kinesin family member 20A
increases expression
ISO fenpyroximate results in increased expression of KIF20A mRNA
CTD PMID:33512557
NCBI chr18:26,230,294...26,238,780
G
Kif5c kinesin family member 5C
decreases expression
ISO fenpyroximate results in decreased expression of KIF5C mRNA
CTD PMID:33512557
NCBI chr 3:34,032,082...34,185,597
G
Klhl24 kelch-like family member 24
increases expression
ISO fenpyroximate results in increased expression of KLHL24 mRNA
CTD PMID:34642769
NCBI chr11:80,843,621...80,877,649
G
Knl1 kinetochore scaffold 1
increases expression
ISO fenpyroximate results in increased expression of KNL1 mRNA
CTD PMID:33512557
NCBI chr 3:106,029,627...106,091,915
G
Kyat3 kynurenine aminotransferase 3
decreases expression
ISO fenpyroximate results in decreased expression of KYAT3 mRNA
CTD PMID:33512557
NCBI chr 2:231,701,881...231,747,462
G
Loxl1 lysyl oxidase-like 1
decreases expression
ISO fenpyroximate results in decreased expression of LOXL1 mRNA
CTD PMID:33512557
NCBI chr 8:58,691,763...58,716,365
G
Lrrc41 leucine rich repeat containing 41
decreases expression
ISO fenpyroximate results in decreased expression of LRRC41 mRNA
CTD PMID:33512557
NCBI chr 5:129,554,547...129,575,450
G
Manf mesencephalic astrocyte-derived neurotrophic factor
increases expression
ISO fenpyroximate results in increased expression of MANF mRNA
CTD PMID:33512557
NCBI chr 8:107,500,856...107,551,595
G
Map1b microtubule-associated protein 1B
decreases expression
ISO fenpyroximate results in decreased expression of MAP1B mRNA
CTD PMID:33512557
NCBI chr 2:30,817,261...30,910,458
G
Map6 microtubule-associated protein 6
decreases expression
ISO fenpyroximate results in decreased expression of MAP6 mRNA
CTD PMID:33512557
NCBI chr 1:153,568,020...153,634,415
G
Mcm7 minichromosome maintenance complex component 7
increases expression
ISO fenpyroximate results in increased expression of MCM7 mRNA
CTD PMID:33512557
NCBI chr12:17,042,207...17,049,470
G
Mdk midkine
increases expression
ISO fenpyroximate results in increased expression of MDK mRNA
CTD PMID:33512557
NCBI chr 3:77,901,134...77,903,997
G
Me1 malic enzyme 1
increases expression
ISO fenpyroximate results in increased expression of ME1 mRNA
CTD PMID:33512557
NCBI chr 8:87,549,043...87,660,251
G
Mki67 marker of proliferation Ki-67
increases expression
ISO fenpyroximate results in increased expression of MKI67 mRNA
CTD PMID:33512557
NCBI chr 1:190,496,319...190,522,983
G
Mllt11 MLLT11, transcription factor 7 cofactor
decreases expression
ISO fenpyroximate results in decreased expression of MLLT11 mRNA
CTD PMID:33512557
NCBI chr 2:182,795,790...182,804,960
G
Mnat1 MNAT1 component of CDK activating kinase
decreases expression
ISO fenpyroximate results in decreased expression of MNAT1 mRNA
CTD PMID:33512557
NCBI chr 6:91,814,703...91,971,945
G
Morn2 MORN repeat containing 2
decreases expression
ISO fenpyroximate results in decreased expression of MORN2 mRNA
CTD PMID:33512557
NCBI chr 6:14,718,799...14,725,281
G
Msi2 musashi RNA-binding protein 2
decreases expression
ISO fenpyroximate results in decreased expression of MSI2 mRNA
CTD PMID:33512557
NCBI chr10:73,143,760...73,510,566
G
Mta1 metastasis associated 1
decreases expression
ISO fenpyroximate results in decreased expression of MTA1 mRNA
CTD PMID:33512557
NCBI chr 6:132,178,608...132,217,641
G
Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
increases expression
ISO fenpyroximate results in increased expression of MTHFD2 mRNA
CTD PMID:33512557
NCBI chr 4:115,811,135...115,822,663
G
Nav1 neuron navigator 1
decreases expression
ISO fenpyroximate results in decreased expression of NAV1 mRNA
CTD PMID:33512557
NCBI chr13:46,866,972...47,119,368
G
Ncan neurocan
decreases expression
ISO fenpyroximate results in decreased expression of NCAN mRNA
CTD PMID:33512557
NCBI chr16:19,301,969...19,328,436
G
Ndufa1 NADH:ubiquinone oxidoreductase subunit A1
increases expression
ISO fenpyroximate results in increased expression of NDUFA1 mRNA
CTD PMID:33512557
NCBI chr X:116,424,223...116,427,875
G
Nek2 NIMA-related kinase 2
increases expression
ISO fenpyroximate results in increased expression of NEK2 mRNA
CTD PMID:33512557
NCBI chr13:103,405,818...103,419,063
G
Nfatc3 nuclear factor of activated T-cells 3
decreases expression
ISO fenpyroximate results in decreased expression of NFATC3 mRNA
CTD PMID:33512557
NCBI chr19:33,960,643...34,035,150
G
Nfe2l2 NFE2 like bZIP transcription factor 2
increases activity
ISO fenpyroximate results in increased activity of NFE2L2 protein
CTD PMID:30818834
NCBI chr 3:60,594,239...60,621,712
G
Nfil3 nuclear factor, interleukin 3 regulated
decreases expression
ISO fenpyroximate results in decreased expression of NFIL3 mRNA
CTD PMID:33512557
NCBI chr17:12,280,499...12,295,728
G
Nfkbib NFKB inhibitor beta
decreases expression
ISO fenpyroximate results in decreased expression of NFKBIB mRNA
CTD PMID:33512557
NCBI chr 1:84,046,292...84,053,862
G
Nit1 nitrilase 1
decreases expression
ISO fenpyroximate results in decreased expression of NIT1 mRNA
CTD PMID:33512557
NCBI chr13:83,769,888...83,773,324
G
Nmnat3 nicotinamide nucleotide adenylyltransferase 3
decreases response to substance
ISO NMNAT3 protein results in decreased susceptibility to fenpyroximate
CTD PMID:18463239
NCBI chr 8:98,892,168...99,003,912
G
Nos3 nitric oxide synthase 3
increases expression
ISO fenpyroximate results in increased expression of NOS3 mRNA
CTD PMID:34642769
NCBI chr 4:10,793,834...10,814,170
G
Notch3 notch receptor 3
decreases expression
ISO fenpyroximate results in decreased expression of NOTCH3 mRNA
CTD PMID:33512557
NCBI chr 7:11,132,984...11,184,025
G
Nqo1 NAD(P)H quinone dehydrogenase 1
increases expression
ISO fenpyroximate results in increased expression of NQO1 mRNA
CTD PMID:33512557
NCBI chr19:35,295,633...35,310,528
G
Nr2f1 nuclear receptor subfamily 2, group F, member 1
decreases expression
ISO fenpyroximate results in decreased expression of NR2F1 mRNA
CTD PMID:33512557
NCBI chr 2:8,040,375...8,050,123
G
Nr3c1 nuclear receptor subfamily 3, group C, member 1
increases expression
ISO fenpyroximate results in increased expression of NR3C1 mRNA
CTD PMID:33512557
NCBI chr18:31,271,681...31,393,320
G
Nr5a1 nuclear receptor subfamily 5, group A, member 1
decreases expression
ISO fenpyroximate results in decreased expression of NR5A1 mRNA
CTD PMID:33512557
NCBI chr 3:22,464,786...22,486,328
G
Nrcam neuronal cell adhesion molecule
decreases expression
ISO fenpyroximate results in decreased expression of NRCAM mRNA
CTD PMID:33512557
NCBI chr 6:61,402,813...61,698,536
G
Nrxn1 neurexin 1
decreases expression
ISO fenpyroximate results in decreased expression of NRXN1 mRNA
CTD PMID:33512557
NCBI chr 6:3,177,788...4,323,848
G
Ntrk1 neurotrophic receptor tyrosine kinase 1
decreases expression
ISO fenpyroximate results in decreased expression of NTRK1 mRNA
CTD PMID:33512557
NCBI chr 2:173,236,961...173,253,806
G
Oaz1 ornithine decarboxylase antizyme 1
increases expression
ISO fenpyroximate results in increased expression of OAZ1 mRNA
CTD PMID:33512557
NCBI chr 7:8,883,855...8,886,315
G
Olfml2b olfactomedin-like 2B
decreases expression
ISO fenpyroximate results in decreased expression of OLFML2B mRNA
CTD PMID:33512557
NCBI chr13:82,869,414...82,906,607
G
Ostc oligosaccharyltransferase complex non-catalytic subunit
increases expression
ISO fenpyroximate results in increased expression of OSTC mRNA
CTD PMID:33512557
NCBI chr 2:219,250,549...219,266,076
G
Pafah1b3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3
decreases expression
ISO fenpyroximate results in decreased expression of PAFAH1B3 mRNA
CTD PMID:33512557
NCBI chr 1:80,881,263...80,883,789
G
Park7 Parkinsonism associated deglycase
decreases response to substance
ISO PARK7 protein results in decreased susceptibility to fenpyroximate
CTD PMID:21219333
NCBI chr 5:161,353,718...161,376,993
G
Parp2 poly (ADP-ribose) polymerase 2
increases expression
ISO fenpyroximate results in increased expression of PARP2 mRNA
CTD PMID:33512557
NCBI chr15:24,034,069...24,044,340
G
Pdia6 protein disulfide isomerase family A, member 6
increases expression
ISO fenpyroximate results in increased expression of PDIA6 mRNA
CTD PMID:33512557
NCBI chr 6:40,062,980...40,080,223
G
Pebp1 phosphatidylethanolamine binding protein 1
decreases expression
ISO fenpyroximate results in decreased expression of PEBP1 mRNA
CTD PMID:33512557
NCBI chr12:39,302,864...39,307,064
G
Peg10 paternally expressed 10
decreases expression
ISO fenpyroximate results in decreased expression of PEG10 mRNA
CTD PMID:33512557
NCBI chr 4:32,842,441...32,855,639
G
Pfkp phosphofructokinase, platelet
increases expression
ISO fenpyroximate results in increased expression of PFKP mRNA
CTD PMID:34642769
NCBI chr17:63,729,743...63,794,026
G
Pgm3 phosphoglucomutase 3
increases expression
ISO fenpyroximate results in increased expression of PGM3 mRNA
CTD PMID:33512557
NCBI chr 8:87,518,317...87,536,021
G
Pgr progesterone receptor
multiple interactions
ISO fenpyroximate inhibits the reaction [Promegestone results in increased activity of PGR protein]
CTD PMID:30818834
NCBI chr 8:6,072,673...6,131,552
G
Phgdh phosphoglycerate dehydrogenase
increases expression
ISO fenpyroximate results in increased expression of PHGDH mRNA
CTD PMID:33512557
NCBI chr 2:185,906,962...185,936,054
G
Phlda1 pleckstrin homology-like domain, family A, member 1
decreases expression
ISO fenpyroximate results in decreased expression of PHLDA1 mRNA
CTD PMID:33512557
NCBI chr 7:46,967,433...46,969,637
G
Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
decreases expression
ISO fenpyroximate results in decreased expression of PIK3C2B mRNA
CTD PMID:33512557
NCBI chr13:44,494,673...44,555,663
G
Pink1 PTEN induced kinase 1
decreases expression
ISO fenpyroximate results in decreased expression of PINK1 mRNA
CTD PMID:33512557
NCBI chr 5:150,530,523...150,542,635
G
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta
decreases expression
ISO fenpyroximate results in decreased expression of PIP4K2B mRNA
CTD PMID:33512557
NCBI chr10:82,706,016...82,734,938
G
Pitpna phosphatidylinositol transfer protein, alpha
decreases expression
ISO fenpyroximate results in decreased expression of PITPNA mRNA
CTD PMID:33512557
NCBI chr10:60,430,712...60,473,564
G
Plin2 perilipin 2
increases expression
ISO fenpyroximate results in increased expression of PLIN2 mRNA
CTD PMID:33512557
NCBI chr 5:101,156,648...101,211,738
G
Pole3 DNA polymerase epsilon 3, accessory subunit
increases expression
ISO fenpyroximate results in increased expression of POLE3 mRNA
CTD PMID:33512557
NCBI chr 5:75,973,941...75,977,175
G
Ppargc1a PPARG coactivator 1 alpha
multiple interactions
ISO fenpyroximate inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]
CTD PMID:30818834
NCBI chr14:58,860,752...59,516,525
G
Ppp2r1a protein phosphatase 2 scaffold subunit A alpha
decreases expression
ISO fenpyroximate results in decreased expression of PPP2R1A mRNA
CTD PMID:33512557
NCBI chr 1:60,540,223...60,559,467
G
Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1
decreases expression
ISO fenpyroximate results in decreased expression of PRKAG1 mRNA
CTD PMID:33512557
NCBI chr 7:129,963,105...129,980,532
G
Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha
decreases expression
ISO fenpyroximate results in decreased expression of PRKAR1A mRNA
CTD PMID:33512557
NCBI chr10:94,621,042...94,639,534
G
Prkn parkin RBR E3 ubiquitin protein ligase
decreases expression
ISO fenpyroximate results in decreased expression of PRKN mRNA
CTD PMID:33512557
NCBI chr 1:48,688,651...49,882,520
G
Prr11 proline rich 11
increases expression
ISO fenpyroximate results in increased expression of PRR11 mRNA
CTD PMID:33512557
NCBI chr10:71,898,858...71,943,325
G
Psat1 phosphoserine aminotransferase 1
increases expression
ISO fenpyroximate results in increased expression of PSAT1 mRNA
CTD PMID:33512557
NCBI chr 1:213,196,709...213,218,564
G
Psma1 proteasome 20S subunit alpha 1
increases expression
ISO fenpyroximate results in increased expression of PSMA1 mRNA
CTD PMID:33512557
NCBI chr 1:168,442,421...168,453,440
G
Ptk2b protein tyrosine kinase 2 beta
decreases expression
ISO fenpyroximate results in decreased expression of PTK2B mRNA
CTD PMID:33512557
NCBI chr15:40,360,722...40,481,235
G
Ripk1 receptor interacting serine/threonine kinase 1
decreases expression
ISO fenpyroximate results in decreased expression of RIPK1 mRNA
CTD PMID:33512557
NCBI chr17:30,839,639...30,871,824
G
Rnf4 ring finger protein 4
increases expression
ISO fenpyroximate results in increased expression of RNF4 mRNA
CTD PMID:33512557
NCBI chr14:76,401,292...76,423,270
G
Rnps1 RNA binding protein with serine rich domain 1
decreases expression
ISO fenpyroximate results in decreased expression of RNPS1 mRNA
CTD PMID:33512557
NCBI chr10:13,445,516...13,455,858
G
Rpa3 replication protein A3
increases expression
ISO fenpyroximate results in increased expression of RPA3 mRNA
CTD PMID:33512557
NCBI chr 4:36,304,649...36,307,755
G
Rpl11 ribosomal protein L11
increases expression
ISO fenpyroximate results in increased expression of RPL11 mRNA
CTD PMID:33512557
NCBI chr 5:148,274,060...148,277,708
G
Rpl17 ribosomal protein L17
increases expression
ISO fenpyroximate results in increased expression of RPL17 mRNA
CTD PMID:33512557
NCBI chr18:68,581,141...68,584,253
G
Rpl27 ribosomal protein L27
increases expression
ISO fenpyroximate results in increased expression of RPL27 mRNA
CTD PMID:33512557
NCBI chr10:86,375,511...86,379,210
G
Rpl28 ribosomal protein L28
increases expression
ISO fenpyroximate results in increased expression of RPL28 mRNA
CTD PMID:33512557
NCBI chr 1:69,052,148...69,054,735
G
Rpl32 ribosomal protein L32
increases expression
ISO fenpyroximate results in increased expression of RPL32 mRNA
CTD PMID:33512557
NCBI chr 4:148,864,048...148,867,612
G
Rpl36 ribosomal protein L36
increases expression
ISO fenpyroximate results in increased expression of RPL36 mRNA
CTD PMID:33512557
NCBI chr 9:1,441,986...1,447,397
G
Rpl36al1 ribosomal protein L36A like 1
increases expression
ISO fenpyroximate results in increased expression of RPL36AL mRNA
CTD PMID:33512557
NCBI chr 6:87,654,808...87,656,202
G
Rpl9 ribosomal protein L9
increases expression
ISO fenpyroximate results in increased expression of RPL9 mRNA
CTD PMID:33512557
NCBI chr14:42,893,945...42,897,140
G
Rps13 ribosomal protein S13
increases expression
ISO fenpyroximate results in increased expression of RPS13 mRNA
CTD PMID:33512557
NCBI chr 1:170,572,925...170,575,355
G
Rps18 ribosomal protein S18
increases expression
ISO fenpyroximate results in increased expression of RPS18 mRNA
CTD PMID:33512557
NCBI chr20:4,931,427...4,935,538
G
Rps2 ribosomal protein S2
increases expression
ISO fenpyroximate results in increased expression of RPS2 mRNA
CTD PMID:33512557
NCBI chr10:13,747,316...13,749,165
G
Rps25 ribosomal protein s25
increases expression
ISO fenpyroximate results in increased expression of RPS25 mRNA
CTD PMID:33512557
NCBI chr 8:44,733,623...44,735,999
G
Rps27a ribosomal protein S27a
increases expression
ISO fenpyroximate results in increased expression of RPS27A mRNA
CTD PMID:33512557
NCBI chr14:103,285,734...103,288,011
G
Rps3 ribosomal protein S3
increases expression
ISO fenpyroximate results in increased expression of RPS3 mRNA
CTD PMID:33512557
NCBI chr 1:153,778,363...153,783,663
G
Rps5 ribosomal protein S5
increases expression
ISO fenpyroximate results in increased expression of RPS5 mRNA
CTD PMID:33512557
NCBI chr 1:73,538,776...73,543,073
G
Rps7 ribosomal protein S7
increases expression
ISO fenpyroximate results in increased expression of RPS7 mRNA
CTD PMID:33512557
NCBI chr 6:45,266,200...45,271,064
G
Rsl24d1 ribosomal L24 domain containing 1
increases expression
ISO fenpyroximate results in increased expression of RSL24D1 mRNA
CTD PMID:33512557
NCBI chr 8:73,852,991...73,861,996
G
S100a13 S100 calcium binding protein A13
increases expression
ISO fenpyroximate results in increased expression of S100A13 mRNA
CTD PMID:33512557
NCBI chr 2:175,999,439...176,005,933
G
S100a4 S100 calcium-binding protein A4
increases expression
ISO fenpyroximate results in increased expression of S100A4 mRNA
CTD PMID:33512557
NCBI chr 2:176,090,951...176,093,258
G
Satb1 SATB homeobox 1
decreases expression
ISO fenpyroximate results in decreased expression of SATB1 mRNA
CTD PMID:33512557
NCBI chr 9:4,677,817...4,773,061
G
Selenos selenoprotein S
increases expression
ISO fenpyroximate results in increased expression of SELENOS mRNA
CTD PMID:33512557
NCBI chr 1:119,659,779...119,669,546
G
Sema4b semaphorin 4B
decreases expression
ISO fenpyroximate results in decreased expression of SEMA4B mRNA
CTD PMID:33512557
NCBI chr 1:134,136,646...134,177,777
G
Sema6d semaphorin 6D
decreases expression
ISO fenpyroximate results in decreased expression of SEMA6D mRNA
CTD PMID:33512557
NCBI chr 3:111,883,415...111,941,100
G
Septin10 septin 10
increases expression
ISO fenpyroximate results in increased expression of SEPTIN10 mRNA
CTD PMID:33512557
NCBI chr20:27,101,764...27,194,997
G
Sertad1 SERTA domain containing 1
increases expression
ISO fenpyroximate results in increased expression of SERTAD1 mRNA
CTD PMID:33512557
NCBI chr 1:82,775,692...82,778,961
G
Sesn2 sestrin 2
increases expression
ISO fenpyroximate results in increased expression of SESN2 mRNA
CTD PMID:33512557
NCBI chr 5:144,702,287...144,721,241
G
Shcbp1 SHC binding and spindle associated 1
increases expression
ISO fenpyroximate results in increased expression of SHCBP1 mRNA
CTD PMID:33512557
NCBI chr16:84,672,277...84,703,843
G
Slc17a6 solute carrier family 17 member 6
decreases expression
ISO fenpyroximate results in decreased expression of SLC17A6 mRNA
CTD PMID:33512557
NCBI chr 1:101,212,489...101,252,543
G
Slc35a5 solute carrier family 35, member A5
decreases expression
ISO fenpyroximate results in decreased expression of SLC35A5 mRNA
CTD PMID:33512557
NCBI chr11:55,653,376...55,674,476
G
Slc38a1 solute carrier family 38, member 1
increases expression
ISO fenpyroximate results in increased expression of SLC38A1 mRNA
CTD PMID:33512557
NCBI chr 7:127,733,230...127,802,541
G
Slc3a2 solute carrier family 3 member 2
increases expression
ISO fenpyroximate results in increased expression of SLC3A2 mRNA
CTD PMID:33512557
NCBI chr 1:205,604,468...205,618,931
G
Slc7a5 solute carrier family 7 member 5
increases expression
ISO fenpyroximate results in increased expression of SLC7A5 mRNA
CTD PMID:33512557
NCBI chr19:49,935,220...49,963,823
G
Smc3 structural maintenance of chromosomes 3
increases expression
ISO fenpyroximate results in increased expression of SMC3 mRNA
CTD PMID:33512557
NCBI chr 1:252,601,422...252,644,522
G
Smndc1 survival motor neuron domain containing 1
decreases expression
ISO fenpyroximate results in decreased expression of SMNDC1 mRNA
CTD PMID:33512557
NCBI chr 1:252,389,675...252,400,749
G
Snai2 snail family transcriptional repressor 2
increases expression
ISO fenpyroximate results in increased expression of SNAI2 mRNA
CTD PMID:33512557
NCBI chr11:86,182,788...86,186,203
G
Snca synuclein alpha
increases response to substance
ISO SNCA protein results in increased susceptibility to fenpyroximate
CTD PMID:16239214
NCBI chr 4:89,696,420...89,797,240
G
Snrpd3 small nuclear ribonucleoprotein D3 polypeptide
increases expression
ISO fenpyroximate results in increased expression of SNRPD3 mRNA
CTD PMID:33512557
NCBI chr20:13,130,112...13,145,947
G
Socs2 suppressor of cytokine signaling 2
decreases expression
ISO fenpyroximate results in decreased expression of SOCS2 mRNA
CTD PMID:33512557
NCBI chr 7:30,006,360...30,045,161
G
Spag5 sperm associated antigen 5
increases expression
ISO fenpyroximate results in increased expression of SPAG5 mRNA
CTD PMID:33512557
NCBI chr10:63,198,717...63,216,746
G
Spc25 SPC25 component of NDC80 kinetochore complex
increases expression
ISO fenpyroximate results in increased expression of SPC25 mRNA
CTD PMID:33512557
NCBI chr 3:53,930,013...53,988,940
G
Spdef SAM pointed domain containing ets transcription factor
decreases expression
ISO fenpyroximate results in decreased expression of SPDEF mRNA
CTD PMID:33512557
NCBI chr20:5,771,440...5,785,893
G
Srsf10 serine and arginine rich splicing factor 10
increases expression
ISO fenpyroximate results in increased expression of SRSF10 mRNA
CTD PMID:33512557
NCBI chr 5:148,088,759...148,102,964
G
Stk25 serine/threonine kinase 25
decreases expression
ISO fenpyroximate results in decreased expression of STK25 mRNA
CTD PMID:33512557
NCBI chr 9:94,161,834...94,174,095
G
Sytl1 synaptotagmin-like 1
increases expression
ISO fenpyroximate results in increased expression of SYTL1 mRNA
CTD PMID:33512557
NCBI chr 5:145,452,524...145,462,940
G
Tacc3 transforming, acidic coiled-coil containing protein 3
increases expression
ISO fenpyroximate results in increased expression of TACC3 mRNA
CTD PMID:33512557
NCBI chr14:77,051,209...77,065,343
G
Tcf4 transcription factor 4
decreases expression
ISO fenpyroximate results in decreased expression of TCF4 mRNA
CTD PMID:33512557
NCBI chr18:62,941,739...63,288,126
G
Tfdp1 transcription factor Dp-1
decreases expression
ISO fenpyroximate results in decreased expression of TFDP1 mRNA
CTD PMID:33512557
NCBI chr16:76,162,040...76,200,871
G
Tgfb3 transforming growth factor, beta 3
decreases expression
ISO fenpyroximate results in decreased expression of TGFB3 mRNA
CTD PMID:33512557
NCBI chr 6:105,704,058...105,726,661
G
Thra thyroid hormone receptor alpha
increases activity
ISO fenpyroximate results in increased activity of THRA protein
CTD PMID:20143881
NCBI chr10:83,701,885...83,729,408
G
Tlk2 tousled-like kinase 2
decreases expression
ISO fenpyroximate results in decreased expression of TLK2 mRNA
CTD PMID:33512557
NCBI chr10:90,154,449...90,248,562
G
Tm9sf3 transmembrane 9 superfamily member 3
decreases expression
ISO fenpyroximate results in decreased expression of TM9SF3 mRNA
CTD PMID:33512557
NCBI chr 1:240,032,060...240,085,125
G
Tmem185a transmembrane protein 185A
decreases expression
ISO fenpyroximate results in decreased expression of TMEM185A mRNA
CTD PMID:33512557
NCBI chr X:149,143,026...149,167,757
G
Tnc tenascin C
decreases expression
ISO fenpyroximate results in decreased expression of TNC mRNA
CTD PMID:33512557
NCBI chr 5:77,375,851...77,460,712
G
Top2a DNA topoisomerase II alpha
increases expression
ISO fenpyroximate results in increased expression of TOP2A mRNA
CTD PMID:33512557
NCBI chr10:83,945,731...83,976,874
G
Tp53 tumor protein p53
increases expression
ISO fenpyroximate results in increased expression of TP53 mRNA
CTD PMID:36933581
NCBI chr10:54,300,070...54,311,525
G
Tpx2 TPX2, microtubule nucleation factor
increases expression
ISO fenpyroximate results in increased expression of TPX2 mRNA
CTD PMID:33512557
NCBI chr 3:141,318,428...141,360,684
G
Trib3 tribbles pseudokinase 3
increases expression
ISO fenpyroximate results in increased expression of TRIB3 mRNA
CTD PMID:33512557
NCBI chr 3:140,809,634...140,815,230
G
Trim13 tripartite motif-containing 13
decreases expression
ISO fenpyroximate results in decreased expression of TRIM13 mRNA
CTD PMID:33512557
NCBI chr15:35,733,548...35,772,676
G
Trpv1 transient receptor potential cation channel, subfamily V, member 1
decreases expression
ISO fenpyroximate results in decreased expression of TRPV1 mRNA
CTD PMID:33512557
NCBI chr10:57,851,428...57,876,513
G
Tsc22d3 TSC22 domain family, member 3
increases expression
ISO fenpyroximate results in increased expression of TSC22D3 mRNA
CTD PMID:33512557
NCBI chr X:104,217,898...104,277,886
G
Tsg101 tumor susceptibility 101
decreases expression
ISO fenpyroximate results in decreased expression of TSG101 mRNA
CTD PMID:33512557
NCBI chr 1:97,412,689...97,442,589
G
Tspan3 tetraspanin 3
decreases expression
ISO fenpyroximate results in decreased expression of TSPAN3 mRNA
CTD PMID:33512557
NCBI chr 8:56,546,067...56,569,815
G
Tst thiosulfate sulfurtransferase
decreases expression
ISO fenpyroximate results in decreased expression of TST mRNA
CTD PMID:33512557
NCBI chr 7:109,948,061...109,955,378
G
Tubb2b tubulin, beta 2B class IIb
decreases expression
ISO fenpyroximate results in decreased expression of TUBB2B mRNA
CTD PMID:33512557
NCBI chr17:30,747,734...30,750,781
G
Txndc5 thioredoxin domain containing 5
increases expression
ISO fenpyroximate results in increased expression of TXNDC5 mRNA
CTD PMID:33512557
NCBI chr17:26,289,880...26,318,025
G
Txnip thioredoxin interacting protein
decreases expression
ISO fenpyroximate results in decreased expression of TXNIP mRNA
CTD PMID:33512557
NCBI chr 2:184,093,079...184,096,882
G
Txnrd1 thioredoxin reductase 1
increases expression
ISO fenpyroximate results in increased expression of TXNRD1 mRNA
CTD PMID:33512557
NCBI chr 7:20,830,042...20,914,990
G
Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1
increases expression
ISO fenpyroximate results in increased expression of UBA52 mRNA
CTD PMID:33512557
NCBI chr16:18,918,614...18,920,807
G
Ube2c ubiquitin-conjugating enzyme E2C
increases expression
ISO fenpyroximate results in increased expression of UBE2C mRNA
CTD PMID:33512557
NCBI chr 3:153,506,636...153,509,036
G
Ube2q2 ubiquitin conjugating enzyme E2 Q2
decreases expression
ISO fenpyroximate results in decreased expression of UBE2Q2 mRNA
CTD PMID:33512557
NCBI chr 8:55,518,402...55,578,342
G
Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII
increases expression
ISO fenpyroximate results in increased expression of UQCRQ mRNA
CTD PMID:33512557
NCBI chr10:37,585,864...37,589,328
G
Vapb VAMP associated protein B and C
decreases expression
ISO fenpyroximate results in decreased expression of VAPB mRNA
CTD PMID:34642769
NCBI chr 3:162,535,974...162,578,747
G
Vegfa vascular endothelial growth factor A
increases expression
ISO fenpyroximate results in increased expression of VEGFA mRNA
CTD PMID:33512557
NCBI chr 9:14,955,300...14,970,641
G
Vgll4 vestigial-like family member 4
decreases expression
ISO fenpyroximate results in decreased expression of VGLL4 mRNA
CTD PMID:33512557
NCBI chr 4:147,925,630...148,038,519
G
Vps72 vacuolar protein sorting 72 homolog
decreases expression
ISO fenpyroximate results in decreased expression of VPS72 mRNA
CTD PMID:33512557
NCBI chr 2:182,678,594...182,690,185
G
Wars1 tryptophanyl-tRNA synthetase 1
increases expression
ISO fenpyroximate results in increased expression of WARS1 mRNA
CTD PMID:33512557
NCBI chr 6:127,776,088...127,807,273
G
Xbp1 X-box binding protein 1
increases expression
ISO fenpyroximate results in increased expression of XBP1 mRNA
CTD PMID:33512557
NCBI chr14:80,390,629...80,395,713
G
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
decreases expression
ISO fenpyroximate results in decreased expression of YWHAB mRNA
CTD PMID:33512557
NCBI chr 3:152,659,663...152,682,105
G
Zbtb41 zinc finger and BTB domain containing 41
decreases expression
ISO fenpyroximate results in decreased expression of ZBTB41 mRNA
CTD PMID:33512557
NCBI chr13:51,042,948...51,065,768
G
Zfand2a zinc finger AN1-type containing 2A
increases expression
ISO fenpyroximate results in increased expression of ZFAND2A mRNA
CTD PMID:33512557
NCBI chr12:15,161,601...15,172,679
G
Zranb2 zinc finger RANBP2-type containing 2
increases expression
ISO fenpyroximate results in increased expression of ZRANB2 mRNA
CTD PMID:33512557
NCBI chr 2:246,573,110...246,586,942
G
Ar androgen receptor
increases activity
ISO lacidipine results in increased activity of AR protein
CTD PMID:25257666
NCBI chr X:63,104,771...63,273,934
G
Esr1 estrogen receptor 1
increases activity
ISO lacidipine results in increased activity of ESR1 protein
CTD PMID:25257666
NCBI chr 1:41,106,335...41,499,104
G
Ncoa2 nuclear receptor coactivator 2
multiple interactions
ISO lacidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]
CTD PMID:27773686
NCBI chr 5:5,835,642...6,069,693
G
Nr1h4 nuclear receptor subfamily 1, group H, member 4
multiple interactions
ISO lacidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; lacidipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; lacidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
CTD PMID:25257666 PMID:27773686
NCBI chr 7:23,846,122...23,942,085
G
Ppard peroxisome proliferator-activated receptor delta
increases activity
ISO lacidipine results in increased activity of PPARD protein
CTD PMID:25257666
NCBI chr20:6,298,785...6,363,970
G
Pparg peroxisome proliferator-activated receptor gamma
increases activity
ISO lacidipine results in increased activity of PPARG protein
CTD PMID:25257666
NCBI chr 4:148,423,102...148,548,471
G
Vdr vitamin D receptor
increases activity
ISO lacidipine results in increased activity of VDR protein
CTD PMID:25257666
NCBI chr 7:128,987,981...129,037,677
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19932
role
19904
application
19741
refrigerant
18307
isobutane
1060
tert-butanol
365
methyl 2-[(tert-butoxycarbonyl)amino]-3-(2-phenoxy-6-quinolyl)acrylate
0
methyl 4-amino-N-(tert-butoxycarbonyl)phenylalaninate
0
methyl N-(tert-butoxycarbonyl)-3-(2-phenoxy-6-quinolyl)alaninate
0
methyl N-(tert-butoxycarbonyl)-3-[2-(2,6-dichlorophenyl)-4-(phenylsulfanyl)-1,2,3,4,4a,8a-hexahydro-6-quinolyl]alaninate
0
methyl N-(tert-butoxycarbonyl)-4-nitrophenylalaninate
0
tert-butyl ester +
353
Path 2
CHEBI ontology
19932
subatomic particle
19930
composite particle
19930
hadron
19930
baryon
19930
nucleon
19930
atomic nucleus
19930
atom
19930
main group element atom
19876
main group molecular entity
19876
s-block molecular entity
19705
hydrogen molecular entity
19686
hydrides
19179
organic hydride
18717
organic fundamental parent
18717
hydrocarbon
18457
alkane
14621
isobutane
1060
tert-butanol
365
methyl 2-[(tert-butoxycarbonyl)amino]-3-(2-phenoxy-6-quinolyl)acrylate
0
methyl 4-amino-N-(tert-butoxycarbonyl)phenylalaninate
0
methyl N-(tert-butoxycarbonyl)-3-(2-phenoxy-6-quinolyl)alaninate
0
methyl N-(tert-butoxycarbonyl)-3-[2-(2,6-dichlorophenyl)-4-(phenylsulfanyl)-1,2,3,4,4a,8a-hexahydro-6-quinolyl]alaninate
0
methyl N-(tert-butoxycarbonyl)-4-nitrophenylalaninate
0
tert-butyl ester +
353
browse the term
