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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:45658 term browser browse the term
Definition:A cysteine derivative that is L-cysteine in which the hydrogen attached to the sulfur is replaced by a methyl group.
Synonyms:related_synonym: (2R)-2-amino-3-(methylsulfanyl)propanoic acid;   (R)-2-amino-3-(methylthio)propanoic acid;   3-(Methylthio)-L-alanine;   Formula=C4H9NO2S;   InChI=1S/C4H9NO2S/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1;   InChIKey=IDIDJDIHTAOVLG-VKHMYHEASA-N;   L-Methylcysteine;   S-methyl-L-cysteine;   SMILES=[C@H](CSC)(C(O)=O)N
 alt_id: CHEBI:22056;   CHEBI:45655;   CHEBI:90363
 xref: CAS:1187-84-4;   DrugBank:DB02216;   HMDB:HMDB0002108
 xref_mesh: MESH:C008425
 xref: MetaCyc:S-METHYL-L-CYSTEINE;   PDBeChem:SMC;   PMID:15161248;   PMID:19367645;   PMID:21110385;   PMID:23417484;   PMID:25650289;   PMID:26887651;   PMID:26928722;   PMID:508804;   PMID:7451605;   PMID:993852;   Reaxys:1721675
 cyclic_relationship: is_tautomer_of CHEBI:133545

show annotations for term's descendants           Sort by:
S-methylcysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Msra methionine sulfoxide reductase A multiple interactions ISO S-methylcysteine promotes the reaction [MSRA protein results in decreased susceptibility to chloramine-T] CTD PMID:19085252 NCBI chr15:38,363,459...38,677,406
Ensembl chr15:38,351,445...38,676,585
JBrowse link
G Pah phenylalanine hydroxylase increases oxidation ISO PAH protein results in increased oxidation of S-methylcysteine CTD PMID:19367645 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        biochemical role 19429
          metabolite 19416
            eukaryotic metabolite 19212
              plant metabolite 17812
                S-methylcysteine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic acid 18518
                                        amino acid 15507
                                          alpha-amino acid 13645
                                            L-alpha-amino acid 12573
                                              serine family amino acid 4831
                                                L-cysteine 3375
                                                  L-cysteine derivative 3366
                                                    S-substituted L-cysteine 2577
                                                      L-cysteine thioether 2510
                                                        S-organyl-L-cysteine 48
                                                          S-hydrocarbyl-L-cysteine 48
                                                            S-alkyl-L-cysteine 2
                                                              S-methylcysteine 2
paths to the root