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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:45658 term browser browse the term
Definition:A cysteine derivative that is L-cysteine in which the hydrogen attached to the sulfur is replaced by a methyl group.
Synonyms:related_synonym: (2R)-2-amino-3-(methylsulfanyl)propanoic acid;   (R)-2-amino-3-(methylthio)propanoic acid;   Formula=C4H9NO2S;   InChI=1S/C4H9NO2S/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1;   InChIKey=IDIDJDIHTAOVLG-VKHMYHEASA-N;   L-3-(methylthio)alanine;   L-Methylcysteine;   S-methyl-L-cysteine;   SMILES=CSC[C@H](N)C(O)=O
 alt_id: CHEBI:22056;   CHEBI:45655;   CHEBI:90363
 xref: CAS:1187-84-4;   DrugBank:DB02216;   HMDB:HMDB0002108
 xref_mesh: MESH:C008425
 xref: MetaCyc:S-METHYL-L-CYSTEINE;   PDBeChem:SMC;   PMID:15161248;   PMID:19367645;   PMID:21110385;   PMID:23417484;   PMID:25650289;   PMID:26887651;   PMID:26928722;   PMID:508804;   PMID:7451605;   PMID:993852;   Reaxys:1721675
 cyclic_relationship: is_tautomer_of CHEBI:133545

show annotations for term's descendants           Sort by:
S-methylcysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Msra methionine sulfoxide reductase A multiple interactions ISO S-methylcysteine promotes the reaction [MSRA protein results in decreased susceptibility to chloramine-T] CTD PMID:19085252 NCBI chr15:38,363,459...38,677,406
Ensembl chr15:38,351,445...38,676,585
JBrowse link
G Pah phenylalanine hydroxylase increases oxidation ISO PAH protein results in increased oxidation of S-methylcysteine CTD PMID:19367645 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            eukaryotic metabolite 19044
              plant metabolite 17455
                S-methylcysteine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        amino acid 14873
                                          alpha-amino acid 12852
                                            L-alpha-amino acid 11559
                                              serine family amino acid 2498
                                                L-cysteine 1325
                                                  L-cysteine derivative 1315
                                                    S-substituted L-cysteine 353
                                                      L-cysteine thioether 276
                                                        S-organyl-L-cysteine 43
                                                          S-hydrocarbyl-L-cysteine 43
                                                            S-alkyl-L-cysteine 2
                                                              S-methylcysteine 2
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