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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:45658 term browser browse the term
Definition:A cysteine derivative that is L-cysteine in which the hydrogen attached to the sulfur is replaced by a methyl group.
Synonyms:related_synonym: (2R)-2-amino-3-(methylsulfanyl)propanoic acid;   (R)-2-amino-3-(methylthio)propanoic acid;   Formula=C4H9NO2S;   InChI=1S/C4H9NO2S/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1;   InChIKey=IDIDJDIHTAOVLG-VKHMYHEASA-N;   L-3-(methylthio)alanine;   L-Methylcysteine;   S-methyl-L-cysteine;   SMILES=CSC[C@H](N)C(O)=O
 alt_id: CHEBI:22056;   CHEBI:45655;   CHEBI:90363
 xref: CAS:1187-84-4;   DrugBank:DB02216;   HMDB:HMDB0002108
 xref_mesh: MESH:C008425
 xref: MetaCyc:S-METHYL-L-CYSTEINE;   PDBeChem:SMC;   PMID:15161248;   PMID:19367645;   PMID:21110385;   PMID:23417484;   PMID:25650289;   PMID:26887651;   PMID:26928722;   PMID:508804;   PMID:7451605;   PMID:993852;   Reaxys:1721675
 cyclic_relationship: is_tautomer_of CHEBI:133545

show annotations for term's descendants           Sort by:
S-methylcysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Msra methionine sulfoxide reductase A multiple interactions ISO S-methylcysteine promotes the reaction [MSRA protein results in decreased susceptibility to chloramine-T] CTD PMID:19085252 NCBI chr15:47,488,333...47,800,662
Ensembl chr15:47,488,894...47,800,024
JBrowse link
G Pah phenylalanine hydroxylase increases oxidation ISO PAH protein results in increased oxidation of S-methylcysteine CTD PMID:19367645 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            eukaryotic metabolite 18908
              plant metabolite 17360
                S-methylcysteine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        amino acid 14072
                                          alpha-amino acid 11539
                                            L-alpha-amino acid 11374
                                              serine family amino acid 1851
                                                L-cysteine 1133
                                                  L-cysteine derivative 1122
                                                    S-substituted L-cysteine 146
                                                      L-cysteine thioether 66
                                                        S-organyl-L-cysteine 43
                                                          S-hydrocarbyl-L-cysteine 43
                                                            S-alkyl-L-cysteine 2
                                                              S-methylcysteine 2
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.