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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:succinylcholine
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Accession:CHEBI:45652 term browser browse the term
Definition:A quaternary ammonium ion that is the bis-choline ester of succinic acid.
Synonyms:related_synonym: 2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM);   Dicholine succinate;   Formula=C14H30N2O4;   InChI=1S/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2;   InChIKey=AXOIZCJOOAYSMI-UHFFFAOYSA-N;   SMILES=C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C;   Succinocholine;   Succinoylcholine;   Succinylbischoline;   Succinyldicholine;   suxamethonium
 alt_id: CHEBI:133060;   CHEBI:45650;   CHEBI:9311
 xref: Beilstein:1805311;   CAS:306-40-1;   DrugBank:DB00202;   Drug_Central:2489;   HMDB:HMDB0014347;   KEGG:C07546
 xref_mesh: MESH:D013390
 xref: PDBeChem:SCK;   PMID:11123992;   PMID:13063382;   PMID:17667569;   PMID:23223104;   PMID:23838346;   PMID:24018151;   PMID:29368335;   PMID:4032432;   PMID:6196640;   PMID:7526642;   PMID:9435889;   Reaxys:1805311


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succinylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase increases response to substance
increases metabolic processing
increases hydrolysis
affects hydrolysis
affects response to substance
decreases hydrolysis
decreases abundance
multiple interactions
ISO BCHE gene mutant form results in increased susceptibility to Succinylcholine; BCHE gene polymorphism results in increased susceptibility to Succinylcholine; BCHE protein mutant form results in increased susceptibility to Succinylcholine
BCHE protein results in increased metabolism of Succinylcholine
BCHE protein results in increased hydrolysis of Succinylcholine
BCHE protein mutant form affects the hydrolysis of Succinylcholine
BCHE affects the susceptibility to Succinylcholine; BCHE gene mutant form affects the susceptibility to Succinylcholine; BCHE gene polymorphism affects the susceptibility to Succinylcholine; BCHE protein affects the susceptibility to Succinylcholine
BCHE protein mutant form results in decreased hydrolysis of Succinylcholine
BCHE protein results in decreased abundance of Succinylcholine
[Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine; Insecticides inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Organophosphorus Compounds inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]
CTD PMID:726855 PMID:900467 PMID:987736 PMID:1058931 PMID:1147298 PMID:1218148 PMID:1218179 PMID:1734774 PMID:1781528 PMID:2249680 PMID:2432808 PMID:4319258 PMID:4698763 PMID:4728581 PMID:4746059 PMID:4850696 PMID:4985882 PMID:4998912 PMID:5365519 PMID:5412891 PMID:5488351 PMID:5673118 PMID:6465587 PMID:6859614 PMID:6928942 PMID:7069741 PMID:7294376 PMID:7378868 PMID:7793179 PMID:8179139 PMID:9110359 PMID:12190811 PMID:12881446 PMID:15688329 PMID:15826794 PMID:16788378 PMID:16884476 PMID:18075469 PMID:18399847 PMID:18555211 PMID:21029050 PMID:21228368 PMID:25054547 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:14645658 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:14645658 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Mb myoglobin increases secretion ISO Succinylcholine results in increased secretion of MB protein CTD PMID:8217179 NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      application 19401
        pharmaceutical 19289
          drug 19289
            neuromuscular agent 1301
              succinylcholine 4
                succinylcholine chloride (anhydrous) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      dicarboxylic acids and O-substituted derivatives 10287
                                        dicarboxylic acid 10279
                                          alpha,omega-dicarboxylic acid 2786
                                            succinic acid 222
                                              succinate ester 113
                                                succinylcholine 4
                                                  succinylcholine chloride (anhydrous) + 0
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