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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sinefungin
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Accession:CHEBI:45453 term browser browse the term
Definition:An adenosine that is the the delta-(5'-adenosyl) derivative of ornithine.
Synonyms:exact_synonym: (5S)-5-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-L-norleucine
 related_synonym: (2S,5S)-2,5-diamino-6-[(2R,3S,R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]hexanoic acid;   6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-beta-D-ribo-decofuranuronic acid;   6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxydecofuranuronic acid;   A 9145;   ADENOSYL-ORNITHINE;   Antibiotic A 9145;   Formula=C15H23N7O5;   InChI=1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1;   InChIKey=LMXOHSDXUQEUSF-YECHIGJVSA-N;   SMILES=N[C@@H](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12;   sinefungina;   sinefungine;   sinefunginum
 xref: CAS:58944-73-3;   KEGG:D05846
 xref_mesh: MESH:C006235
 xref: MetaCyc:SINEFUNGIN;   PDBeChem:SFG;   PMID:20347768;   PMID:20859291;   PMID:21738746;   PMID:21781040;   PMID:22342622;   PMID:22362751;   PMID:22965231;   Patent:US3758681;   Patent:US5872104;   Reaxys:3574678

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sinefungin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP sinefungin results in decreased activity of COMT protein CTD PMID:26577531 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,133...51,403,998 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 879
    role 859
      biological role 859
        antimicrobial agent 231
          sinefungin 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 879
    subatomic particle 864
      composite particle 864
        hadron 864
          baryon 864
            nucleon 864
              atomic nucleus 864
                atom 864
                  main group element atom 854
                    p-block element atom 851
                      carbon group element atom 827
                        carbon atom 826
                          organic molecular entity 826
                            heteroorganic entity 582
                              organochalcogen compound 528
                                organooxygen compound 463
                                  carbohydrates and carbohydrate derivatives 110
                                    carbohydrate 110
                                      carbohydrate derivative 99
                                        glycosyl compound 40
                                          N-glycosyl compound 27
                                            nucleoside 27
                                              ribonucleoside 6
                                                purine ribonucleoside 6
                                                  adenosines 6
                                                    sinefungin 1
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