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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sinefungin
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Accession:CHEBI:45453 term browser browse the term
Definition:An adenosine that is the the delta-(5'-adenosyl) derivative of ornithine.
Synonyms:exact_synonym: (5S)-5-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-L-norleucine
 related_synonym: (2S,5S)-2,5-diamino-6-[(2R,3S,R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]hexanoic acid;   6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-beta-D-ribo-decofuranuronic acid;   6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxydecofuranuronic acid;   A 9145;   ADENOSYL-ORNITHINE;   Antibiotic A 9145;   Formula=C15H23N7O5;   InChI=1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1;   InChIKey=LMXOHSDXUQEUSF-YECHIGJVSA-N;   SMILES=N[C@@H](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12;   sinefungina;   sinefungine;   sinefunginum
 xref: CAS:58944-73-3;   KEGG:D05846
 xref_mesh: MESH:C006235
 xref: MetaCyc:SINEFUNGIN;   PDBeChem:SFG;   PMID:20347768;   PMID:20859291;   PMID:21738746;   PMID:21781040;   PMID:22342622;   PMID:22362751;   PMID:22965231;   Patent:US3758681;   Patent:US5872104;   Reaxys:3574678


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sinefungin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase 1 decreases activity ISO sinefungin results in decreased activity of DNMT1 protein CTD PMID:23671287 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases activity ISO sinefungin results in decreased activity of DNMT3A protein CTD PMID:23671287 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        antimicrobial agent 17329
          sinefungin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            heteroorganic entity 19175
                              organochalcogen compound 18886
                                organooxygen compound 18809
                                  carbohydrates and carbohydrate derivatives 12196
                                    carbohydrate 12196
                                      carbohydrate derivative 11819
                                        glycosyl compound 10861
                                          N-glycosyl compound 5341
                                            nucleoside 5200
                                              ribonucleoside 699
                                                purine ribonucleoside 591
                                                  adenosines 535
                                                    sinefungin 2
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