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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methylcarbamic acid
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Accession:CHEBI:45379 term browser browse the term
Definition:An amino acid consisting of carbamic acid having an N-methyl substituent.
Synonyms:related_synonym: Formula=C2H5NO2;   InChI=1S/C2H5NO2/c1-3-2(4)5/h3H,1H3,(H,4,5);   InChIKey=UFEJKYYYVXYMMS-UHFFFAOYSA-N;   Methylcarbamidsaeure;   Monomethyl carbamate;   N-Methylcarbamate;   N-methylcarbamic acid;   SMILES=CNC(O)=O
 alt_id: CHEBI:38464;   CHEBI:45374
 xref: Beilstein:1738994;   CAS:6414-57-9;   PDBeChem:RGI;   Reaxys:1738994


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aminocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO aminocarb results in decreased activity of ACHE protein CTD PMID:2086312 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
bendiocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP
bendiocarb results in decreased activity of ACHE protein CTD PMID:14644616, PMID:21251949 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP bendiocarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP bendiocarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO bendiocarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO bendiocarb results in increased activity of NFE2L2 protein CTD PMID:20143881 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Pgr progesterone receptor multiple interactions ISO bendiocarb inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
carbaryl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Carbaryl co-treated with Dichlorvos] results in decreased activity of ACHE protein; Obidoxime Chloride promotes the reaction [Carbaryl results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Carbaryl results in decreased activity of ACHE protein]
[Carbaryl co-treated with Chlorpyrifos] results in decreased activity of ACHE protein
CTD PMID:4859365, PMID:7713347, PMID:14644616, PMID:16256972, PMID:19934164, PMID:21251949, PMID:23418109, PMID:23962483, PMID:25707986 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase decreases activity EXP Carbaryl results in decreased activity of AGXT protein CTD PMID:2119399 NCBI chr 9:100,281,339...100,291,292
Ensembl chr 9:100,281,339...100,291,291
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO
EXP
AHR protein affects the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; Carbaryl binds to and results in increased activity of AHR protein; Carbaryl inhibits the reaction [beta-Naphthoflavone binds to and results in increased activity of AHR protein] CTD PMID:9169082, PMID:9853009, PMID:17553063 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Alb albumin increases hydrolysis
multiple interactions
EXP
ISO
ALB protein results in increased hydrolysis of Carbaryl
bis(4-nitrophenyl)phosphate inhibits the reaction [ALB protein results in increased hydrolysis of Carbaryl]
CTD PMID:27665777 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ar androgen receptor affects binding EXP Carbaryl binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
EXP Carbaryl results in decreased activity of BCHE protein
[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein
CTD PMID:20708061, PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2l11 BCL2 like 11 decreases expression ISO Carbaryl results in decreased expression of BCL2L11 mRNA CTD PMID:27829164 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Casp3 caspase 3 increases expression EXP Carbaryl results in increased expression of CASP3 CTD PMID:27296064 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Carbaryl results in decreased expression of CEBPA mRNA CTD PMID:27829164 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14644616 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
increases expression
multiple interactions
ISO
EXP
Carbaryl results in increased activity of CYP1A1 protein
Carbaryl results in increased expression of CYP1A1 mRNA; Carbaryl results in increased expression of CYP1A1 protein
AHR protein affects the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; Methoxsalen inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]
CTD PMID:9169082, PMID:9858662, PMID:11226373 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
decreases activity
ISO
EXP
Carbaryl inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Carbaryl inhibits the reaction [CYP1A2 protein results in increased metabolism of Estradiol]
Carbaryl results in increased expression of CYP1A2 protein
Carbaryl results in decreased activity of CYP1A2 protein
CTD PMID:9858662, PMID:16790556 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression
ISO Carbaryl results in increased activity of CYP2B6 protein
Carbaryl results in increased expression of CYP2B6 mRNA
CTD PMID:22310298 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO Carbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Carbaryl results in decreased activity of CYP2E1 protein
CTD PMID:22634058 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Carbaryl results in increased expression of DDIT3 mRNA CTD PMID:11226373 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Carbaryl results in increased expression of DNAJB4 mRNA CTD PMID:27829164 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Carbaryl results in increased expression of DNAJB9 mRNA CTD PMID:27829164 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Carbaryl results in increased expression of DNAJC3 mRNA CTD PMID:27829164 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G E2f5 E2F transcription factor 5 decreases expression ISO Carbaryl results in decreased expression of E2F5 mRNA CTD PMID:27829164 NCBI chr 2:88,350,764...88,366,913
Ensembl chr 2:88,351,361...88,366,115
JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Carbaryl results in decreased expression of ENC1 mRNA CTD PMID:27829164 NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Carbaryl binds to and results in decreased activity of ESR1 protein; Carbaryl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867, PMID:16626760 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression
ISO Carbaryl binds to and results in decreased activity of ESR2 protein
Carbaryl results in decreased expression of ESR2 mRNA
CTD PMID:16626760, PMID:27829164 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression
ISO Carbaryl results in increased expression of FOS mRNA
Carbaryl results in decreased expression of FOS mRNA
CTD PMID:11226373, PMID:27829164 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo1 forkhead box O1 decreases expression ISO Carbaryl results in decreased expression of FOXO1 mRNA CTD PMID:27829164 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Carbaryl inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]; Carbaryl inhibits the reaction [FSHB protein results in increased secretion of Progesterone] CTD PMID:16413094 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions
EXP Carbaryl results in increased activity of G6PD protein
[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein; Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein]
CTD PMID:27214522 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression ISO Carbaryl results in decreased expression of GADD45B mRNA CTD PMID:27829164 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Carbaryl results in increased expression of GCLM mRNA CTD PMID:27829164 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpx5 glutathione peroxidase 5 increases expression ISO Carbaryl results in increased expression of GPX5 mRNA CTD PMID:27829164 NCBI chr17:45,508,657...45,518,686
Ensembl chr17:45,467,015...45,518,686
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Carbaryl results in increased expression of HERPUD1 mRNA CTD PMID:27829164 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Carbaryl results in increased expression of HMOX1 mRNA CTD PMID:27829164 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Carbaryl results in increased expression of HSPA5 mRNA CTD PMID:11226373, PMID:27829164 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein] CTD PMID:15907790, PMID:18177342 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Carbaryl analog results in decreased susceptibility to IL2 protein; Carbaryl results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity EXP Carbaryl results in decreased activity of KYAT1 protein CTD PMID:2119399 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO Carbaryl results in decreased expression of MITF mRNA CTD PMID:27829164 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Mtnr1a melatonin receptor 1A affects binding
multiple interactions
ISO Carbaryl binds to MTNR1A protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1A protein]
CTD PMID:28027439 NCBI chr16:50,339,358...50,358,809
Ensembl chr16:50,339,358...50,358,809
JBrowse link
G Mtnr1b melatonin receptor 1B affects binding
multiple interactions
ISO Carbaryl binds to MTNR1B protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]; Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]
CTD PMID:28027439 NCBI chr 8:14,359,270...14,373,894
Ensembl chr 8:14,359,270...14,373,894
JBrowse link
G Nefh neurofilament heavy increases phosphorylation ISO Carbaryl results in increased phosphorylation of NEFH protein CTD PMID:16256972 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:15907790, PMID:17015962 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Mercaptoethanol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:15907790 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
increases activity
ISO
EXP
Carbaryl results in increased expression of NR1I2 mRNA
Carbaryl results in increased activity of NR1I2 protein
CTD PMID:22310298, PMID:27665777 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity EXP Carbaryl results in increased activity of NR1I3 protein CTD PMID:27665777 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pdxk pyridoxal kinase decreases activity ISO Carbaryl results in decreased activity of PDXK protein CTD PMID:2547861 NCBI chr20:10,930,651...10,952,194
Ensembl chr20:10,930,518...10,952,391
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Carbaryl inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity EXP Carbaryl results in decreased activity of PNPLA6 protein CTD PMID:7713347 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity EXP Carbaryl results in increased activity of PPARA protein CTD PMID:27665777 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:15907790 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression
ISO Carbaryl inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]
Carbaryl results in decreased expression of STAR mRNA
CTD PMID:16413094 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity ISO
EXP
Carbaryl results in decreased activity of TDO2 protein CTD PMID:2119399, PMID:2547861 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO Carbaryl results in increased expression of TGFB2 mRNA CTD PMID:27829164 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
affects binding
ISO Carbaryl binds to and results in decreased activity of THRB protein
Carbaryl binds to THRB protein
CTD PMID:18584933, PMID:28973306 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tpo thyroid peroxidase increases activity ISO Carbaryl results in increased activity of TPO protein CTD PMID:21809831 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Wnt6 Wnt family member 6 decreases expression ISO Carbaryl results in decreased expression of WNT6 mRNA CTD PMID:27829164 NCBI chr 9:82,033,543...82,047,172
Ensembl chr 9:82,033,543...82,047,166
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Carbaryl results in increased expression of XBP1 mRNA CTD PMID:27829164 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
ethiofencarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO croneton inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] CTD PMID:26647222 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
fenobucarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thrb thyroid hormone receptor beta affects binding ISO BPMC binds to THRB protein CTD PMID:28973306 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
formetanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP formetanate results in decreased activity of ACHE protein CTD PMID:19934164, PMID:21251949 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO formetanate results in decreased expression of HSPA1A protein CTD PMID:16271832 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO formetanate results in increased expression of HSPA5 protein CTD PMID:16271832 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO formetanate results in decreased expression of HSPA8 protein CTD PMID:16271832 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO formetanate results in increased activity of NFE2L2 protein CTD PMID:20143881 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
methiocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP Methiocarb results in decreased activity of ACHE protein CTD PMID:19934164 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin increases hydrolysis
multiple interactions
ISO
EXP
ALB protein results in increased hydrolysis of Methiocarb
bis(4-nitrophenyl)phosphate inhibits the reaction [ALB protein results in increased hydrolysis of Methiocarb]
CTD PMID:27665777 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ar androgen receptor multiple interactions ISO
EXP
Dihydrotestosterone inhibits the reaction [Methiocarb results in increased activity of AR protein]; Methiocarb inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Methiocarb inhibits the reaction [Metribolone results in increased activity of AR protein]
Methiocarb inhibits the reaction [Metribolone results in increased expression of AR mRNA]
CTD PMID:15064155, PMID:15519604, PMID:18324785, PMID:21310686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases metabolic processing
ISO [CYP2B6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing
multiple interactions
ISO CYP2C19 protein results in increased metabolism of Methiocarb
[CYP2C19 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide
CTD PMID:27665777 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions
ISO CYP2D6 protein results in increased metabolism of Methiocarb
[CYP2D6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide
CTD PMID:27665777 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Esr1 estrogen receptor 1 increases activity
increases expression
ISO Methiocarb results in increased activity of ESR1 protein
Methiocarb results in increased expression of ESR1 protein
CTD PMID:15064155, PMID:19206145 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases activity
increases expression
ISO Methiocarb results in increased activity of ESR2 protein
Methiocarb results in increased expression of ESR2 mRNA
CTD PMID:15064155, PMID:15130599 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 multiple interactions
increases metabolic processing
ISO [FMO1 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Methiocarb results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Methiocarb results in decreased expression of LHB protein CTD PMID:15519604 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity EXP Methiocarb results in increased activity of NR1I2 protein CTD PMID:27665777 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression EXP Methiocarb results in decreased expression of ODC1 mRNA CTD PMID:15519604 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity EXP Methiocarb results in increased activity of PPARA protein CTD PMID:27665777 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Methiocarb binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Scgb2a2 secretoglobin, family 2A, member 2 decreases expression EXP Methiocarb results in decreased expression of SCGB2A2 mRNA CTD PMID:15519604 NCBI chr 1:225,825,419...225,830,374
Ensembl chr 1:225,825,356...225,830,355
Ensembl chr 1:225,825,356...225,830,355
JBrowse link
methomyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
methamidophos promotes the reaction [Methomyl results in decreased activity of ACHE protein]; Methomyl promotes the reaction [methamidophos results in decreased activity of ACHE protein] CTD PMID:8134223, PMID:19371631, PMID:19934164, PMID:21251949, PMID:23962483, PMID:25707986 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO Methomyl results in increased activity of CYP19A1 protein CTD PMID:11884232 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Methomyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Methomyl results in increased expression of FSHB protein CTD PMID:11516254 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression ISO Methomyl results in decreased expression of HSP90B1 protein CTD PMID:16271832 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO Methomyl results in decreased expression of HSPA1A protein CTD PMID:16271832 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Methomyl results in increased expression of HSPA5 protein CTD PMID:16271832 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO Methomyl results in decreased expression of HSPA8 protein CTD PMID:16271832 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity ISO Methomyl results in decreased activity of KYAT1 protein CTD PMID:7175100 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Kynu kynureninase decreases activity ISO Methomyl results in decreased activity of KYNU protein CTD PMID:7175100 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Methomyl results in increased expression of LHB protein CTD PMID:11516254 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Methomyl inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Prl prolactin increases expression EXP Methomyl results in increased expression of PRL protein CTD PMID:11516254 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
metolcarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thrb thyroid hormone receptor beta affects binding ISO metolcarb binds to THRB protein CTD PMID:28973306 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
oxamyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO
oxamyl results in decreased activity of ACHE protein CTD PMID:19934164, PMID:21251949, PMID:27132127 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO oxamyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Pgr progesterone receptor multiple interactions ISO oxamyl inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO
EXP
[Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to oxamyl
[Calcium results in increased activity of PON1 protein] which affects the susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which affects the susceptibility to oxamyl
CTD PMID:27132127 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
propoxur term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
Obidoxime Chloride promotes the reaction [Propoxur results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Propoxur results in decreased activity of ACHE protein] CTD PMID:14644616, PMID:19934164, PMID:21251949, PMID:23962483 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP [Propoxur co-treated with Permethrin] results in increased activity of CAT protein; Melatonin inhibits the reaction [Propoxur results in decreased activity of CAT protein] CTD PMID:24733834, PMID:28456543 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Propoxur results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Propoxur results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Propoxur inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Propoxur inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
thiodicarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP
thiodicarb results in decreased activity of ACHE protein CTD PMID:21251949 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      application 19363
        refrigerant 17409
          ammonia 16931
            organic amino compound 16930
              amino acid 14055
                methylcarbamic acid 74
                  XMC 0
                  aminocarb 1
                  bendiocarb 6
                  carbaryl 57
                  ethiofencarb 1
                  fenobucarb 1
                  formetanate 6
                  isoprocarb 0
                  methiocarb 17
                  methomyl + 14
                  metolcarb 1
                  oxamyl 5
                  propoxur 7
                  thiofanox 0
                  xylylcarb 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic group 18488
                              organic divalent group 18481
                                organodiyl group 18481
                                  carbonyl group 18384
                                    carbonyl compound 18384
                                      carboxylic acid 18054
                                        amino acid 14055
                                          methylcarbamic acid 74
                                            XMC 0
                                            aminocarb 1
                                            bendiocarb 6
                                            carbaryl 57
                                            ethiofencarb 1
                                            fenobucarb 1
                                            formetanate 6
                                            isoprocarb 0
                                            methiocarb 17
                                            methomyl + 14
                                            metolcarb 1
                                            oxamyl 5
                                            propoxur 7
                                            thiofanox 0
                                            xylylcarb 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.