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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrazinecarboxamide
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Accession:CHEBI:45285 term browser browse the term
Definition:A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Synonyms:related_synonym: 2-carbamylpyrazine;   2-pyrazinecarboxamide;   Formula=C5H5N3O;   InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9);   InChIKey=IPEHBUMCGVEMRF-UHFFFAOYSA-N;   PYRAZINE-2-CARBOXAMIDE;   Pyrazinoic acid amide;   SMILES=NC(=O)c1cnccn1;   pyrazinamida;   pyrazinamide;   pyrazinamidum;   pyrazine carboxamide;   pyrazineamide
 alt_id: CHEBI:45281;   CHEBI:8656
 xref: Beilstein:112306;   CAS:98-96-4;   DrugBank:DB00339;   Drug_Central:2328;   Gmelin:279021;   HMDB:HMDB0014483;   KEGG:C01956;   KEGG:D00144;   LINCS:LSM-5425
 xref_mesh: MESH:D011718
 xref: PDBeChem:PZA;   PMID:14977529;   PMID:18517115;   PMID:18604033;   Reaxys:112306;   Wikipedia:Pyrazinamide


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pyrazinecarboxamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression EXP Pyrazinamide results in increased expression of ABCA1 mRNA CTD PMID:22431067 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abca3 ATP binding cassette subfamily A member 3 decreases expression EXP Pyrazinamide results in decreased expression of ABCA3 mRNA CTD PMID:22431067 NCBI chr10:13,723,365...13,780,558
Ensembl chr10:13,723,405...13,779,963
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
multiple interactions
EXP Pyrazinamide results in decreased expression of ABCB11 mRNA; Pyrazinamide results in decreased expression of ABCB11 protein
obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCB11 mRNA]
CTD PMID:27255380 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCB4 mRNA]
Pyrazinamide results in decreased expression of ABCB4 mRNA; Pyrazinamide results in decreased expression of ABCB4 protein
CTD PMID:27255380 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 increases expression EXP Pyrazinamide results in increased expression of ABCB6 mRNA CTD PMID:22431067 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCC2 mRNA]
Pyrazinamide results in decreased expression of ABCC2 mRNA; Pyrazinamide results in decreased expression of ABCC2 protein
CTD PMID:27255380 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Pyrazinamide results in increased expression of ABCC3 mRNA; Pyrazinamide results in increased expression of ABCC3 protein CTD PMID:27255380 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg3l1 ATP-binding cassette, subfamily G (WHITE), member 3-like 1 decreases expression EXP Pyrazinamide results in decreased expression of ABCG3L1 mRNA CTD PMID:22431067 NCBI chr14:6,488,655...6,541,220
Ensembl chr14:6,435,167...6,541,191
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases expression
multiple interactions
EXP Pyrazinamide results in increased expression of ACAA1 mRNA
Fenofibrate promotes the reaction [Pyrazinamide results in increased expression of ACAA1 mRNA]; Pyrazinamide promotes the reaction [Fenofibrate results in increased expression of ACAA1 mRNA]
CTD PMID:22431067, PMID:27071702 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B increases expression EXP Pyrazinamide results in increased expression of ACAA1B mRNA CTD PMID:22431067 NCBI chr 8:127,836,235...127,845,296 JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 increases expression EXP Pyrazinamide results in increased expression of ACSM2 mRNA CTD PMID:22431067 NCBI chr 1:189,289,957...189,329,007
Ensembl chr 1:189,289,957...189,395,276
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP Pyrazinamide results in increased expression of AKR7A3 mRNA CTD PMID:22431067 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Pyrazinamide results in increased expression of ALDH1A1 mRNA CTD PMID:22431067 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 increases expression EXP Pyrazinamide results in increased expression of ALDH1L1 mRNA CTD PMID:22431067 NCBI chr 4:123,516,553...123,564,067
Ensembl chr 4:123,516,788...123,557,501
JBrowse link
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase decreases expression EXP Pyrazinamide results in decreased expression of ALKBH2 mRNA CTD PMID:22431067 NCBI chr12:48,257,575...48,262,244
Ensembl chr12:48,257,609...48,262,243
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
increases expression
EXP [Fenofibrate co-treated with Pyrazinamide] results in increased expression of APOA1 mRNA
Pyrazinamide results in increased expression of APOA1 mRNA
CTD PMID:22431067, PMID:27071702 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Pyrazinamide results in increased expression of ASNS mRNA CTD PMID:22431067 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atf3 activating transcription factor 3 increases expression EXP Pyrazinamide results in increased expression of ATF3 mRNA CTD PMID:22431067 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]
Pyrazinamide results in increased expression of ATF4 mRNA; Pyrazinamide results in increased expression of ATF4 protein
CTD PMID:28063906 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Pyrazinamide results in increased expression of ATF6 mRNA CTD PMID:28063906 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Bcl2l10 BCL2 like 10 decreases expression EXP Pyrazinamide results in decreased expression of BCL2L10 mRNA CTD PMID:22431067 NCBI chr 8:82,288,705...82,294,750
Ensembl chr 8:82,288,705...82,294,744
JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression EXP Pyrazinamide results in decreased expression of BCL2L2 mRNA CTD PMID:22431067 NCBI chr15:33,543,774...33,549,165
Ensembl chr15:33,544,312...33,549,164
JBrowse link
G Bcl7c BAF chromatin remodeling complex subunit BCL7C increases expression EXP Pyrazinamide results in increased expression of BCL7C mRNA CTD PMID:22431067 NCBI chr 1:199,112,192...199,159,125
Ensembl chr 1:199,155,296...199,159,125
JBrowse link
G Bmf Bcl2 modifying factor decreases expression EXP Pyrazinamide results in decreased expression of BMF mRNA CTD PMID:22431067 NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Pyrazinamide results in increased cleavage of CASP3 protein CTD PMID:28063906 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 decreases expression EXP Pyrazinamide results in decreased expression of CCAR1 mRNA CTD PMID:22431067 NCBI chr20:32,373,443...32,416,044
Ensembl chr20:32,373,443...32,416,044
JBrowse link
G Ccne2 cyclin E2 decreases expression EXP Pyrazinamide results in decreased expression of CCNE2 mRNA CTD PMID:22431067 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cdk20 cyclin-dependent kinase 20 decreases expression EXP Pyrazinamide results in decreased expression of CDK20 mRNA CTD PMID:22431067 NCBI chr17:1,935,900...1,942,867
Ensembl chr17:1,936,163...1,942,865
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Pyrazinamide results in increased expression of CDK4 mRNA CTD PMID:22431067 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression EXP Pyrazinamide results in increased expression of CEBPB mRNA CTD PMID:22431067 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP Pyrazinamide results in increased expression of CEBPD mRNA CTD PMID:22431067 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression EXP Pyrazinamide results in increased expression of COL1A1 mRNA CTD PMID:22431067 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression
multiple interactions
EXP Pyrazinamide results in decreased expression of CPT1B mRNA
Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of CPT1B mRNA]
CTD PMID:22431067, PMID:27071702 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP Pyrazinamide results in increased expression of CYP1A2 mRNA CTD PMID:22431067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Pyrazinamide results in increased expression of CYP2B1 mRNA CTD PMID:22431067 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Pyrazinamide results in increased expression of CYP2B2 mRNA CTD PMID:22431067 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 increases expression EXP Pyrazinamide results in increased expression of CYP2B21 mRNA CTD PMID:22431067 NCBI chr 1:83,389,783...83,418,613
Ensembl chr 1:83,389,788...83,418,777
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases expression EXP Pyrazinamide results in increased expression of CYP2D4 mRNA CTD PMID:22431067 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2d5 cytochrome P450, family 2, subfamily d, polypeptide 5 increases expression EXP Pyrazinamide results in increased expression of CYP2D5 mRNA CTD PMID:22431067 NCBI chr 7:123,616,596...123,621,102
Ensembl chr 7:123,616,596...123,621,102
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA] CTD PMID:27919644 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp2j3 cytochrome P450, family 2, subfamily j, polypeptide 3 decreases expression EXP Pyrazinamide results in decreased expression of CYP2J3 mRNA CTD PMID:22431067 NCBI chr 5:115,196,982...115,222,084 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] CTD PMID:27919644 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Pyrazinamide results in increased expression of CYP3A23-3A1 mRNA CTD PMID:22431067 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases expression EXP Pyrazinamide results in decreased expression of CYP3A9 mRNA CTD PMID:22431067 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP Pyrazinamide results in increased expression of CYP51 mRNA CTD PMID:22431067 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP Pyrazinamide results in increased expression of CYP7A1 mRNA; Pyrazinamide results in increased expression of CYP7A1 protein CTD PMID:27255380 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression
increases expression
EXP Pyrazinamide results in decreased expression of CYP8B1 mRNA; Pyrazinamide results in decreased expression of CYP8B1 protein
Pyrazinamide results in increased expression of CYP8B1 mRNA
CTD PMID:22431067, PMID:27255380 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
EXP
ISO
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of DDIT3 protein]
Pyrazinamide results in increased expression of DDIT3 mRNA; Pyrazinamide results in increased expression of DDIT3 protein
CTD PMID:28063906 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 decreases expression EXP Pyrazinamide results in decreased expression of DYRK2 mRNA CTD PMID:22431067 NCBI chr 7:61,785,423...61,816,775
Ensembl chr 7:61,786,309...61,798,729
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein] CTD PMID:28063906 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions
ISO
EXP
Pyrazinamide results in increased phosphorylation of EIF2S1 protein
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]
CTD PMID:28063906 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Ep300 E1A binding protein p300 decreases expression EXP Pyrazinamide results in decreased expression of EP300 mRNA CTD PMID:22431067 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP Pyrazinamide results in increased expression of EPHX1 mRNA CTD PMID:22431067 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression EXP Pyrazinamide results in increased expression of ERCC1 mRNA CTD PMID:22431067 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO Pyrazinamide results in increased expression of ERN1 mRNA CTD PMID:28063906 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions
decreases expression
EXP Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of FABP1 mRNA] CTD PMID:27071702 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fabp7 fatty acid binding protein 7 decreases expression EXP Pyrazinamide results in decreased expression of FABP7 mRNA CTD PMID:22431067 NCBI chr20:40,769,624...40,773,156
Ensembl chr20:40,769,586...40,773,349
JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 decreases expression EXP Pyrazinamide results in decreased expression of FBXW11 mRNA CTD PMID:22431067 NCBI chr10:17,542,374...17,640,718
Ensembl chr10:17,542,374...17,640,718
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression EXP Pyrazinamide results in increased expression of FMO1 mRNA CTD PMID:22431067 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Pyrazinamide results in increased expression of GADD45A mRNA CTD PMID:22431067 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gas2 growth arrest-specific 2 increases expression EXP Pyrazinamide results in increased expression of GAS2 mRNA CTD PMID:22431067 NCBI chr 1:107,234,389...107,363,624
Ensembl chr 1:107,262,659...107,363,788
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions
EXP Pyrazinamide results in increased expression of GPT protein
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of GPT protein]; Fenofibrate inhibits the reaction [Pyrazinamide results in increased expression of GPT protein]
CTD PMID:27071702, PMID:28063906 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression EXP Pyrazinamide results in increased expression of GSTA4 mRNA CTD PMID:22431067 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Pyrazinamide results in increased expression of GSTA5 mRNA CTD PMID:22431067 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP Pyrazinamide results in increased expression of GSTM1 mRNA CTD PMID:22431067 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Pyrazinamide results in increased expression of GSTM2 mRNA CTD PMID:22431067 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Pyrazinamide results in increased expression of GSTP1 mRNA CTD PMID:22431067 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO GSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide] CTD PMID:18397238 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP Pyrazinamide results in increased expression of HMGCS1 mRNA CTD PMID:22431067 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression EXP Pyrazinamide results in increased expression of HMGCS2 mRNA CTD PMID:22431067 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Pyrazinamide results in increased expression of HMOX1 mRNA CTD PMID:22431067 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases expression EXP Pyrazinamide results in increased expression of HSD11B1 mRNA CTD PMID:22431067 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
EXP
ISO
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of HSPA5 protein]
Pyrazinamide results in increased expression of HSPA5 mRNA; Pyrazinamide results in increased expression of HSPA5 protein
CTD PMID:28063906 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression EXP Pyrazinamide results in decreased expression of ITPR1 mRNA CTD PMID:22431067 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Lpl lipoprotein lipase decreases expression
multiple interactions
EXP Pyrazinamide results in decreased expression of LPL mRNA
Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of LPL mRNA]
CTD PMID:27071702 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Me1 malic enzyme 1 increases expression EXP Pyrazinamide results in increased expression of ME1 mRNA CTD PMID:22431067, PMID:27071702 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 increases expression EXP Pyrazinamide results in increased expression of MGST3 mRNA CTD PMID:22431067 NCBI chr13:85,601,499...85,622,392
Ensembl chr13:85,601,499...85,622,314
JBrowse link
G Mixl1 Mix paired-like homeobox 1 decreases expression EXP Pyrazinamide results in decreased expression of MIXL1 mRNA CTD PMID:22431067 NCBI chr13:97,278,258...97,282,299
Ensembl chr13:98,973,041...98,975,426
Ensembl chr13:98,973,041...98,975,426
JBrowse link
G Mrps14 mitochondrial ribosomal protein S14 decreases expression EXP Pyrazinamide results in decreased expression of MRPS14 mRNA CTD PMID:22431067 NCBI chr13:77,940,454...77,946,201
Ensembl chr13:77,940,454...77,946,201
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR0B2 mRNA] CTD PMID:27255380 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR1H4 mRNA]
Pyrazinamide results in decreased expression of NR1H4 mRNA; Pyrazinamide results in decreased expression of NR1H4 protein
CTD PMID:27255380 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression EXP Pyrazinamide results in increased expression of NSDHL mRNA CTD PMID:22431067 NCBI chr  X:152,933,118...152,964,399
Ensembl chr  X:152,933,069...152,964,390
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 decreases expression EXP Pyrazinamide results in decreased expression of NTRK1 mRNA CTD PMID:22431067 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression EXP Pyrazinamide results in increased expression of PERP mRNA CTD PMID:22431067 NCBI chr 1:14,224,392...14,236,838
Ensembl chr 1:14,224,393...14,236,846
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Pyrazinamide results in increased expression of PHGDH mRNA CTD PMID:22431067 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression
ISO
EXP
[Pyrazinamide co-treated with Glucose] binds to PPARA protein; Pyrazinamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]
Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of PPARA mRNA]
Pyrazinamide results in decreased expression of PPARA mRNA; Pyrazinamide results in decreased expression of PPARA protein
CTD PMID:18812576, PMID:27071702 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression EXP Pyrazinamide results in increased expression of PPP2R1A mRNA CTD PMID:22431067 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609
JBrowse link
G Prom1 prominin 1 decreases expression EXP Pyrazinamide results in decreased expression of PROM1 mRNA CTD PMID:22431067 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
JBrowse link
G Slc10a1 solute carrier family 10 member 1 increases expression EXP Pyrazinamide results in increased expression of SLC10A1 mRNA; Pyrazinamide results in increased expression of SLC10A1 protein CTD PMID:27255380 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc16a11 solute carrier family 16, member 11 decreases expression EXP Pyrazinamide results in decreased expression of SLC16A11 mRNA CTD PMID:22431067 NCBI chr10:56,822,697...56,826,480
Ensembl chr10:56,822,756...56,826,479
JBrowse link
G Slc17a1 solute carrier family 17 member 1 increases expression EXP Pyrazinamide results in increased expression of SLC17A1 mRNA CTD PMID:22431067 NCBI chr17:43,473,048...43,504,645 JBrowse link
G Slc22a12 solute carrier family 22 member 12 affects activity ISO Pyrazinamide affects the activity of SLC22A12 protein CTD PMID:14694169 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a13 solute carrier family 22 member 13 decreases expression EXP Pyrazinamide results in decreased expression of SLC22A13 mRNA CTD PMID:22431067 NCBI chr 8:127,885,268...127,900,829
Ensembl chr 8:127,885,268...127,900,463
JBrowse link
G Slc25a39 solute carrier family 25, member 39 increases expression EXP Pyrazinamide results in increased expression of SLC25A39 mRNA CTD PMID:22431067 NCBI chr10:90,351,899...90,356,905
Ensembl chr10:90,351,900...90,356,242
JBrowse link
G Slc25a4 solute carrier family 25 member 4 decreases expression EXP Pyrazinamide results in decreased expression of SLC25A4 mRNA CTD PMID:22431067 NCBI chr16:49,266,903...49,270,698
Ensembl chr16:49,266,903...49,270,698
JBrowse link
G Slc25a42 solute carrier family 25, member 42 decreases expression EXP Pyrazinamide results in decreased expression of SLC25A42 mRNA CTD PMID:22431067 NCBI chr16:20,962,144...21,000,191
Ensembl chr16:20,962,227...20,985,225
JBrowse link
G Slc29a1 solute carrier family 29 member 1 decreases expression EXP Pyrazinamide results in decreased expression of SLC29A1 mRNA CTD PMID:22431067 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
JBrowse link
G Slc51a solute carrier family 51 subunit alpha decreases expression EXP Pyrazinamide results in decreased expression of SLC51A mRNA; Pyrazinamide results in decreased expression of SLC51A protein CTD PMID:27255380 NCBI chr11:71,533,078...71,547,476
Ensembl chr11:71,533,078...71,547,476
JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of SLC51B mRNA]
Pyrazinamide results in decreased expression of SLC51B mRNA; Pyrazinamide results in decreased expression of SLC51B protein
CTD PMID:27255380 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression EXP Pyrazinamide results in decreased expression of SLC6A9 mRNA CTD PMID:22431067 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
G Slc7a10 solute carrier family 7 member 10 decreases expression EXP Pyrazinamide results in decreased expression of SLC7A10 mRNA CTD PMID:22431067 NCBI chr 1:91,432,952...91,448,566
Ensembl chr 1:91,433,030...91,448,564
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression EXP Pyrazinamide results in increased expression of SLCO1A4 mRNA; Pyrazinamide results in increased expression of SLCO1A4 protein CTD PMID:27255380 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
multiple interactions
EXP Pyrazinamide results in decreased expression of SLCO1B2 mRNA; Pyrazinamide results in decreased expression of SLCO1B2 protein
obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of SLCO1B2 mRNA]
CTD PMID:27255380 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 decreases expression EXP Pyrazinamide results in decreased expression of SLCO4A1 mRNA CTD PMID:22431067 NCBI chr 3:175,838,994...175,857,985
Ensembl chr 3:175,838,994...175,857,983
JBrowse link
G Srm spermidine synthase increases expression EXP Pyrazinamide results in increased expression of SRM mRNA CTD PMID:22431067 NCBI chr 5:165,405,168...165,408,325
Ensembl chr 5:165,405,168...165,408,320
JBrowse link
G Sult1c2a sulfotransferase family, cytosolic, 1C, member 2a decreases expression EXP Pyrazinamide results in decreased expression of SULT1C2A mRNA CTD PMID:22431067 NCBI chr 9:4,152,588...4,168,355
Ensembl chr 9:4,152,589...4,168,221
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP Pyrazinamide results in decreased expression of SULT2A1 mRNA CTD PMID:22431067 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator decreases expression EXP Pyrazinamide results in decreased expression of TICRR mRNA CTD PMID:22431067 NCBI chr 1:141,391,738...141,433,615
Ensembl chr 1:141,391,262...141,433,109
JBrowse link
G Tmem176a transmembrane protein 176A increases expression EXP Pyrazinamide results in increased expression of TMEM176A mRNA CTD PMID:22431067 NCBI chr 4:78,458,735...78,462,415
Ensembl chr 4:78,458,625...78,462,423
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression EXP Pyrazinamide results in increased expression of UGT1A2 mRNA CTD PMID:22431067 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression EXP Pyrazinamide results in increased expression of VDAC1 mRNA CTD PMID:22431067 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Pyrazinamide results in increased expression of XBP1 mRNA alternative form CTD PMID:28063906 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta increases expression EXP Pyrazinamide results in increased expression of YWHAH mRNA CTD PMID:22431067 NCBI chr14:83,053,041...83,062,424
Ensembl chr14:83,053,041...83,062,424
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pro-agent 8829
          prodrug 8609
            pyrazinecarboxamide 113
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                monocarboxylic acid amide 14551
                                                  pyrazinecarboxamide 113
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.