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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrazinecarboxamide
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Accession:CHEBI:45285 term browser browse the term
Definition:A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Synonyms:related_synonym: 2-carbamylpyrazine;   2-pyrazinecarboxamide;   Formula=C5H5N3O;   InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9);   InChIKey=IPEHBUMCGVEMRF-UHFFFAOYSA-N;   PYRAZINE-2-CARBOXAMIDE;   Pyrazinoic acid amide;   SMILES=NC(=O)c1cnccn1;   pyrazinamida;   pyrazinamide;   pyrazinamidum;   pyrazine carboxamide;   pyrazineamide
 alt_id: CHEBI:45281;   CHEBI:8656
 xref: Beilstein:112306;   CAS:98-96-4;   DrugBank:DB00339;   Drug_Central:2328;   Gmelin:279021;   HMDB:HMDB0014483;   KEGG:C01956;   KEGG:D00144;   LINCS:LSM-5425
 xref_mesh: MESH:D011718
 xref: PDBeChem:PZA;   PMID:14977529;   PMID:18517115;   PMID:18604033;   Reaxys:112306;   Wikipedia:Pyrazinamide


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pyrazinecarboxamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression EXP Pyrazinamide results in increased expression of ABCA1 mRNA CTD PMID:22431067 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abca3 ATP binding cassette subfamily A member 3 decreases expression EXP Pyrazinamide results in decreased expression of ABCA3 mRNA CTD PMID:22431067 NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
multiple interactions
EXP Pyrazinamide results in decreased expression of ABCB11 mRNA; Pyrazinamide results in decreased expression of ABCB11 protein
obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCB11 mRNA]
CTD PMID:27255380 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCB4 mRNA]
Pyrazinamide results in decreased expression of ABCB4 mRNA; Pyrazinamide results in decreased expression of ABCB4 protein
CTD PMID:27255380 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 increases expression EXP Pyrazinamide results in increased expression of ABCB6 mRNA CTD PMID:22431067 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCC2 mRNA]
Pyrazinamide results in decreased expression of ABCC2 mRNA; Pyrazinamide results in decreased expression of ABCC2 protein
CTD PMID:27255380 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Pyrazinamide results in increased expression of ABCC3 mRNA; Pyrazinamide results in increased expression of ABCC3 protein CTD PMID:27255380 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcg3l1 ATP-binding cassette, subfamily G (WHITE), member 3-like 1 decreases expression EXP Pyrazinamide results in decreased expression of ABCG3L1 mRNA CTD PMID:22431067 NCBI chr14:5,124,541...5,177,265
Ensembl chr14:5,124,353...5,177,184
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases expression
multiple interactions
EXP Pyrazinamide results in increased expression of ACAA1 mRNA
Fenofibrate promotes the reaction [Pyrazinamide results in increased expression of ACAA1 mRNA]; Pyrazinamide promotes the reaction [Fenofibrate results in increased expression of ACAA1 mRNA]
CTD PMID:22431067 PMID:27071702 NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B increases expression EXP Pyrazinamide results in increased expression of ACAA1B mRNA CTD PMID:22431067 NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825
JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 increases expression EXP Pyrazinamide results in increased expression of ACSM2 mRNA CTD PMID:22431067 NCBI chr 1:173,916,368...173,955,116
Ensembl chr 1:173,916,368...173,955,116
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP Pyrazinamide results in increased expression of AKR7A3 mRNA CTD PMID:22431067 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Pyrazinamide results in increased expression of ALDH1A1 mRNA CTD PMID:22431067 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 increases expression EXP Pyrazinamide results in increased expression of ALDH1L1 mRNA CTD PMID:22431067 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
JBrowse link
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase decreases expression EXP Pyrazinamide results in decreased expression of ALKBH2 mRNA CTD PMID:22431067 NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
increases expression
EXP [Fenofibrate co-treated with Pyrazinamide] results in increased expression of APOA1 mRNA
Pyrazinamide results in increased expression of APOA1 mRNA
CTD PMID:22431067 PMID:27071702 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Pyrazinamide results in increased expression of ASNS mRNA CTD PMID:22431067 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Atf3 activating transcription factor 3 increases expression EXP Pyrazinamide results in increased expression of ATF3 mRNA CTD PMID:22431067 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]
Pyrazinamide results in increased expression of ATF4 mRNA; Pyrazinamide results in increased expression of ATF4 protein
CTD PMID:28063906 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Pyrazinamide results in increased expression of ATF6 mRNA CTD PMID:28063906 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Bcl2l10 BCL2 like 10 decreases expression EXP Pyrazinamide results in decreased expression of BCL2L10 mRNA CTD PMID:22431067 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367
JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression EXP Pyrazinamide results in decreased expression of BCL2L2 mRNA CTD PMID:22431067 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
JBrowse link
G Bcl7c BAF chromatin remodeling complex subunit BCL7C increases expression EXP Pyrazinamide results in increased expression of BCL7C mRNA CTD PMID:22431067 NCBI chr 1:182,277,163...182,324,274
Ensembl chr 1:182,260,164...182,324,163
JBrowse link
G Bmf Bcl2 modifying factor decreases expression EXP Pyrazinamide results in decreased expression of BMF mRNA CTD PMID:22431067 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Pyrazinamide results in increased cleavage of CASP3 protein CTD PMID:28063906 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 decreases expression EXP Pyrazinamide results in decreased expression of CCAR1 mRNA CTD PMID:22431067 NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
JBrowse link
G Ccne2 cyclin E2 decreases expression EXP Pyrazinamide results in decreased expression of CCNE2 mRNA CTD PMID:22431067 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Cdk20 cyclin-dependent kinase 20 decreases expression EXP Pyrazinamide results in decreased expression of CDK20 mRNA CTD PMID:22431067 NCBI chr17:701,122...707,869
Ensembl chr17:701,124...707,826
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Pyrazinamide results in increased expression of CDK4 mRNA CTD PMID:22431067 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D increases expression EXP Pyrazinamide results in increased expression of CDKN2D mRNA CTD PMID:22431067 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression EXP Pyrazinamide results in increased expression of CEBPB mRNA CTD PMID:22431067 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP Pyrazinamide results in increased expression of CEBPD mRNA CTD PMID:22431067 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression EXP Pyrazinamide results in increased expression of COL1A1 mRNA CTD PMID:22431067 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression
multiple interactions
EXP Pyrazinamide results in decreased expression of CPT1B mRNA
Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of CPT1B mRNA]
CTD PMID:22431067 PMID:27071702 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP Pyrazinamide results in increased expression of CYP1A2 mRNA CTD PMID:22431067 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Pyrazinamide results in increased expression of CYP2B1 mRNA CTD PMID:22431067 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Pyrazinamide results in increased expression of CYP2B2 mRNA CTD PMID:22431067 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 increases expression EXP Pyrazinamide results in increased expression of CYP2B21 mRNA CTD PMID:22431067 NCBI chr 1:81,886,097...81,915,066
Ensembl chr 1:81,886,098...81,915,066
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases expression EXP Pyrazinamide results in increased expression of CYP2D4 mRNA CTD PMID:22431067 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2d5 cytochrome P450, family 2, subfamily d, polypeptide 5 increases expression EXP Pyrazinamide results in increased expression of CYP2D5 mRNA CTD PMID:22431067 NCBI chr 7:113,899,905...113,904,458
Ensembl chr 7:113,899,890...113,904,495
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA] CTD PMID:27919644 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2j3 cytochrome P450, family 2, subfamily j, polypeptide 3 decreases expression EXP Pyrazinamide results in decreased expression of CYP2J3 mRNA CTD PMID:22431067 NCBI chr 5:111,219,921...111,244,987 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] CTD PMID:27919644 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Pyrazinamide results in increased expression of CYP3A23-3A1 mRNA CTD PMID:22431067 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases expression EXP Pyrazinamide results in decreased expression of CYP3A9 mRNA CTD PMID:22431067 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP Pyrazinamide results in increased expression of CYP51 mRNA CTD PMID:22431067 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP Pyrazinamide results in increased expression of CYP7A1 mRNA; Pyrazinamide results in increased expression of CYP7A1 protein CTD PMID:27255380 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression
increases expression
EXP Pyrazinamide results in decreased expression of CYP8B1 mRNA; Pyrazinamide results in decreased expression of CYP8B1 protein
Pyrazinamide results in increased expression of CYP8B1 mRNA
CTD PMID:22431067 PMID:27255380 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
EXP
ISO
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of DDIT3 protein]
Pyrazinamide results in increased expression of DDIT3 mRNA; Pyrazinamide results in increased expression of DDIT3 protein
CTD PMID:28063906 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 decreases expression EXP Pyrazinamide results in decreased expression of DYRK2 mRNA CTD PMID:22431067 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein] CTD PMID:28063906 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions
ISO
EXP
Pyrazinamide results in increased phosphorylation of EIF2S1 protein
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]
CTD PMID:28063906 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Ep300 E1A binding protein p300 decreases expression EXP Pyrazinamide results in decreased expression of EP300 mRNA CTD PMID:22431067 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP Pyrazinamide results in increased expression of EPHX1 mRNA CTD PMID:22431067 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression EXP Pyrazinamide results in increased expression of ERCC1 mRNA CTD PMID:22431067 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO Pyrazinamide results in increased expression of ERN1 mRNA CTD PMID:28063906 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions
decreases expression
EXP Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of FABP1 mRNA] CTD PMID:27071702 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fabp7 fatty acid binding protein 7 decreases expression EXP Pyrazinamide results in decreased expression of FABP7 mRNA CTD PMID:22431067 NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880
JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 decreases expression EXP Pyrazinamide results in decreased expression of FBXW11 mRNA CTD PMID:22431067 NCBI chr10:17,232,735...17,330,584
Ensembl chr10:17,227,181...17,330,571
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression EXP Pyrazinamide results in increased expression of FMO1 mRNA CTD PMID:22431067 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Pyrazinamide results in increased expression of GADD45A mRNA CTD PMID:22431067 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gas2 growth arrest-specific 2 increases expression EXP Pyrazinamide results in increased expression of GAS2 mRNA CTD PMID:22431067 NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions
EXP Pyrazinamide results in increased expression of GPT protein
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of GPT protein]; Fenofibrate inhibits the reaction [Pyrazinamide results in increased expression of GPT protein]
CTD PMID:27071702 PMID:28063906 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression EXP Pyrazinamide results in increased expression of GSTA4 mRNA CTD PMID:22431067 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Pyrazinamide results in increased expression of GSTA5 mRNA CTD PMID:22431067 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP Pyrazinamide results in increased expression of GSTM1 mRNA CTD PMID:22431067 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Pyrazinamide results in increased expression of GSTM2 mRNA CTD PMID:22431067 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Pyrazinamide results in increased expression of GSTP1 mRNA CTD PMID:22431067 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO GSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide] CTD PMID:18397238 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP Pyrazinamide results in increased expression of HMGCS1 mRNA CTD PMID:22431067 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression EXP Pyrazinamide results in increased expression of HMGCS2 mRNA CTD PMID:22431067 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Pyrazinamide results in increased expression of HMOX1 mRNA CTD PMID:22431067 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases expression EXP Pyrazinamide results in increased expression of HSD11B1 mRNA CTD PMID:22431067 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
EXP
ISO
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of HSPA5 protein]
Pyrazinamide results in increased expression of HSPA5 mRNA; Pyrazinamide results in increased expression of HSPA5 protein
CTD PMID:28063906 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression EXP Pyrazinamide results in decreased expression of ITPR1 mRNA CTD PMID:22431067 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G LOC685081 similar to solute carrier family 22 (organic cation transporter), member 13 decreases expression EXP Pyrazinamide results in decreased expression of SLC22A13 mRNA CTD PMID:22431067 NCBI chr 8:118,958,209...118,972,614
Ensembl chr 8:118,961,000...118,966,046
JBrowse link
G Lpl lipoprotein lipase decreases expression
multiple interactions
EXP Pyrazinamide results in decreased expression of LPL mRNA
Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of LPL mRNA]
CTD PMID:27071702 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Me1 malic enzyme 1 increases expression EXP Pyrazinamide results in increased expression of ME1 mRNA CTD PMID:22431067 PMID:27071702 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 increases expression EXP Pyrazinamide results in increased expression of MGST3 mRNA CTD PMID:22431067 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
JBrowse link
G Mixl1 Mix paired-like homeobox 1 decreases expression EXP Pyrazinamide results in decreased expression of MIXL1 mRNA CTD PMID:22431067 NCBI chr13:92,422,031...92,426,065
Ensembl chr13:92,422,031...92,426,065
JBrowse link
G Mrps14 mitochondrial ribosomal protein S14 decreases expression EXP Pyrazinamide results in decreased expression of MRPS14 mRNA CTD PMID:22431067 NCBI chr13:72,429,168...72,434,915
Ensembl chr13:72,408,558...72,434,915
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR0B2 mRNA] CTD PMID:27255380 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR1H4 mRNA]
Pyrazinamide results in decreased expression of NR1H4 mRNA; Pyrazinamide results in decreased expression of NR1H4 protein
CTD PMID:27255380 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression EXP Pyrazinamide results in increased expression of NSDHL mRNA CTD PMID:22431067 NCBI chr  X:150,775,034...150,807,161
Ensembl chr  X:150,775,080...150,807,142
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 decreases expression EXP Pyrazinamide results in decreased expression of NTRK1 mRNA CTD PMID:22431067 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression EXP Pyrazinamide results in increased expression of PERP mRNA CTD PMID:22431067 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Pyrazinamide results in increased expression of PHGDH mRNA CTD PMID:22431067 NCBI chr 2:185,906,964...185,936,160
Ensembl chr 2:185,906,966...185,935,944
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression
ISO
EXP
[Pyrazinamide co-treated with Glucose] binds to PPARA protein; Pyrazinamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]
Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of PPARA mRNA]
Pyrazinamide results in decreased expression of PPARA mRNA; Pyrazinamide results in decreased expression of PPARA protein
CTD PMID:18812576 PMID:27071702 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression EXP Pyrazinamide results in increased expression of PPP2R1A mRNA CTD PMID:22431067 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
JBrowse link
G Prom1 prominin 1 decreases expression EXP Pyrazinamide results in decreased expression of PROM1 mRNA CTD PMID:22431067 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G Slc10a1 solute carrier family 10 member 1 increases expression EXP Pyrazinamide results in increased expression of SLC10A1 mRNA; Pyrazinamide results in increased expression of SLC10A1 protein CTD PMID:27255380 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc16a11 solute carrier family 16, member 11 decreases expression EXP Pyrazinamide results in decreased expression of SLC16A11 mRNA CTD PMID:22431067 NCBI chr10:54,929,129...54,933,021
Ensembl chr10:54,927,725...54,942,915
JBrowse link
G Slc17a1 solute carrier family 17 member 1 increases expression EXP Pyrazinamide results in increased expression of SLC17A1 mRNA CTD PMID:22431067 NCBI chr17:41,219,461...41,255,199 JBrowse link
G Slc22a12 solute carrier family 22 member 12 affects activity ISO Pyrazinamide affects the activity of SLC22A12 protein CTD PMID:14694169 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc25a39 solute carrier family 25, member 39 increases expression EXP Pyrazinamide results in increased expression of SLC25A39 mRNA CTD PMID:22431067 NCBI chr10:87,362,494...87,367,358
Ensembl chr10:87,362,490...87,367,260
JBrowse link
G Slc25a4 solute carrier family 25 member 4 decreases expression EXP Pyrazinamide results in decreased expression of SLC25A4 mRNA CTD PMID:22431067 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
JBrowse link
G Slc25a42 solute carrier family 25, member 42 decreases expression EXP Pyrazinamide results in decreased expression of SLC25A42 mRNA CTD PMID:22431067 NCBI chr16:19,213,914...19,251,990
Ensembl chr16:19,213,950...19,237,025
JBrowse link
G Slc29a1 solute carrier family 29 member 1 decreases expression EXP Pyrazinamide results in decreased expression of SLC29A1 mRNA CTD PMID:22431067 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Slc51a solute carrier family 51 subunit alpha decreases expression EXP Pyrazinamide results in decreased expression of SLC51A mRNA; Pyrazinamide results in decreased expression of SLC51A protein CTD PMID:27255380 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of SLC51B mRNA]
Pyrazinamide results in decreased expression of SLC51B mRNA; Pyrazinamide results in decreased expression of SLC51B protein
CTD PMID:27255380 NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression EXP Pyrazinamide results in decreased expression of SLC6A9 mRNA CTD PMID:22431067 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
JBrowse link
G Slc7a10 solute carrier family 7 member 10 decreases expression EXP Pyrazinamide results in decreased expression of SLC7A10 mRNA CTD PMID:22431067 NCBI chr 1:87,829,084...87,845,073
Ensembl chr 1:87,829,175...87,845,071
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression EXP Pyrazinamide results in increased expression of SLCO1A4 mRNA; Pyrazinamide results in increased expression of SLCO1A4 protein CTD PMID:27255380 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
multiple interactions
EXP Pyrazinamide results in decreased expression of SLCO1B2 mRNA; Pyrazinamide results in decreased expression of SLCO1B2 protein
obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of SLCO1B2 mRNA]
CTD PMID:27255380 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 decreases expression EXP Pyrazinamide results in decreased expression of SLCO4A1 mRNA CTD PMID:22431067 NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305
JBrowse link
G Srm spermidine synthase increases expression EXP Pyrazinamide results in increased expression of SRM mRNA CTD PMID:22431067 NCBI chr 5:159,025,919...159,029,076
Ensembl chr 5:159,025,873...159,029,405
JBrowse link
G Sult1c2a sulfotransferase family, cytosolic, 1C, member 2a decreases expression EXP Pyrazinamide results in decreased expression of SULT1C2A mRNA CTD PMID:22431067 NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP Pyrazinamide results in decreased expression of SULT2A1 mRNA CTD PMID:22431067 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator decreases expression EXP Pyrazinamide results in decreased expression of TICRR mRNA CTD PMID:22431067 NCBI chr 1:133,597,618...133,639,513
Ensembl chr 1:133,597,716...133,639,523
JBrowse link
G Tmem176a transmembrane protein 176A increases expression EXP Pyrazinamide results in increased expression of TMEM176A mRNA CTD PMID:22431067 NCBI chr 4:77,774,940...77,778,620
Ensembl chr 4:77,774,843...77,778,620
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression EXP Pyrazinamide results in increased expression of UGT1A2 mRNA CTD PMID:22431067 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression EXP Pyrazinamide results in increased expression of VDAC1 mRNA CTD PMID:22431067 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Pyrazinamide results in increased expression of XBP1 mRNA alternative form CTD PMID:28063906 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta increases expression EXP Pyrazinamide results in increased expression of YWHAH mRNA CTD PMID:22431067 NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pro-agent 10095
          prodrug 9899
            pyrazinecarboxamide 114
              N-butyl-5-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrazine-2-carboxamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                monocarboxylic acid amide 15014
                                                  pyrazinecarboxamide 114
                                                    N-butyl-5-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrazine-2-carboxamide 0
paths to the root