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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:4518 term browser browse the term
Definition:An olefinic compound that is hexa-2,4-diene substituted by 4-hydroxyphenyl groups at positions 3 and 4 respectively.
Synonyms:exact_synonym: 4,4'-hexa-2,4-diene-3,4-diyldiphenol
 related_synonym: 4,4'-Hydroxy-gamma,delta-diphenyl-beta,delta-hexadiene;   Dehydrostilbestrol;   Di(p-oxyphenyl)-2,4-hexadiene;   Formula=C18H18O2;   InChI=1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3;   InChIKey=NFDFQCUYFHCNBW-UHFFFAOYSA-N;   SMILES=CC=C(c1ccc(O)cc1)C(=CC)c1ccc(O)cc1;   p,p'-(Diethylideneethylene)diphenol
 xref: CAS:84-17-3;   DrugBank:DB00890;   KEGG:C08090;   KEGG:D00898;   LINCS:LSM-4142
 xref_mesh: MESH:D004028
 xref: PMID:18275104;   PMID:25188907;   Patent:US2464203;   Patent:US2465505;   Reaxys:2053692;   Wikipedia:Dienestrol

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dienestrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP Dienestrol binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP [Dienestrol co-treated with Flutamide] results in increased expression of CYP17A1 mRNA CTD PMID:32738380 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases activity
affects binding
ISO Dienestrol binds to and results in increased activity of ESR1 protein; Dienestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Dienestrol promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]
Dienestrol results in decreased activity of ESR1 protein
Dienestrol binds to ESR1 protein
CTD PMID:9048584 PMID:15026083 PMID:18976723 PMID:19233257 PMID:25012808 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
EXP Dienestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]
Dienestrol binds to Esr2 protein
CTD PMID:9048584 PMID:9048584 RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Dienestrol inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Dienestrol results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Dienestrol binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO Dienestrol results in decreased activity of SULT1E1 protein CTD PMID:16914110 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link

Term paths to the root
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  CHEBI ontology 19808
    chemical entity 19808
      atom 19807
        nonmetal atom 19694
          carbon atom 19616
            organic molecular entity 19616
              olefinic compound 15500
                dienestrol 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic molecule 19556
                              organic cyclic compound 19347
                                organic aromatic compound 19172
                                  phenols 18144
                                    dienestrol 8
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