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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dienestrol
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Accession:CHEBI:4518 term browser browse the term
Definition:An olefinic compound that is hexa-2,4-diene substituted by 4-hydroxyphenyl groups at positions 3 and 4 respectively.
Synonyms:exact_synonym: 4,4'-hexa-2,4-diene-3,4-diyldiphenol
 related_synonym: 4,4'-Hydroxy-gamma,delta-diphenyl-beta,delta-hexadiene;   Dehydrostilbestrol;   Di(p-oxyphenyl)-2,4-hexadiene;   Formula=C18H18O2;   InChI=1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3;   InChIKey=NFDFQCUYFHCNBW-UHFFFAOYSA-N;   SMILES=CC=C(c1ccc(O)cc1)C(=CC)c1ccc(O)cc1;   p,p'-(Diethylideneethylene)diphenol
 xref: CAS:84-17-3;   DrugBank:DB00890;   KEGG:C08090;   KEGG:D00898;   LINCS:LSM-4142
 xref_mesh: MESH:D004028
 xref: PMID:18275104;   PMID:25188907;   Patent:US2464203;   Patent:US2465505;   Reaxys:2053692;   Wikipedia:Dienestrol


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dienestrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP Dienestrol binds to AFP protein CTD PMID:23013281, PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP [Dienestrol co-treated with Flutamide] results in increased expression of CYP17A1 mRNA CTD PMID:32738380 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases activity
affects binding
ISO Dienestrol binds to and results in increased activity of ESR1 protein; Dienestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Dienestrol promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]
Dienestrol results in decreased activity of ESR1 protein
Dienestrol binds to ESR1 protein
CTD PMID:9048584, PMID:15026083, PMID:18976723, PMID:19233257, PMID:25012808 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions EXP Dienestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein] CTD PMID:9048584 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Dienestrol inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Dienestrol results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Dienestrol binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO Dienestrol results in decreased activity of SULT1E1 protein CTD PMID:16914110 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      atom 19784
        nonmetal atom 19659
          carbon atom 19563
            organic molecular entity 19563
              olefinic compound 14457
                dienestrol 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic aromatic compound 19119
                                  phenols 18112
                                    dienestrol 8
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