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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Dictamnine
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Accession:CHEBI:4512 term browser browse the term
Definition:An alkaloid antibiotic that has formula C12H9NO2.
Synonyms:related_synonym: Formula=C12H9NO2;   InChI=1S/C12H9NO2/c1-14-11-8-4-2-3-5-10(8)13-12-9(11)6-7-15-12/h2-7H,1H3;   InChIKey=WIONIXOBNMDJFJ-UHFFFAOYSA-N;   SMILES=COc1c2ccoc2nc2ccccc12
 xref: CAS:484-29-7;   KEGG:C10660;   KNApSAcK:C00002151;   LINCS:LSM-2642
 xref_mesh: MESH:C026398



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Dictamnine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO [dictamnine co-treated with Oxygen deficiency] results in increased expression of CDH1 protein; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH1 mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH1 protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH1 mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH1 protein]
dictamnine results in increased expression of CDH1 protein
CTD PMID:30266538 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 decreases expression
multiple interactions
ISO dictamnine results in decreased expression of CDH2 protein
[dictamnine co-treated with Oxygen deficiency] results in decreased expression of CDH2 protein; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH2 mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH2 protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH2 mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH2 protein]
CTD PMID:30266538 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [dictamnine co-treated with Oxygen deficiency] results in decreased phosphorylation of EIF4E protein CTD PMID:30266538 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [dictamnine co-treated with Oxygen deficiency] results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:30266538 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO dictamnine inhibits the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein] CTD PMID:30266538 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
ISO dictamnine inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; dictamnine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH1 mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH1 protein]; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH2 mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH2 protein]; dictamnine promotes the reaction [HIF1A protein affects the expression of OCLN mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of OCLN protein]; dictamnine promotes the reaction [HIF1A protein affects the expression of VIM mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of VIM protein]
dictamnine results in decreased expression of HIF1A protein
CTD PMID:30266538 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO dictamnine inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein] CTD PMID:30266538 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO dictamnine inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK14 protein] CTD PMID:30266538 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO dictamnine inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein] CTD PMID:30266538 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO dictamnine inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK8 protein] CTD PMID:30266538 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [dictamnine co-treated with Oxygen deficiency] results in decreased phosphorylation of MTOR protein CTD PMID:30266538 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Ocln occludin multiple interactions ISO [dictamnine co-treated with Oxygen deficiency] results in increased expression of OCLN protein; dictamnine promotes the reaction [HIF1A protein affects the expression of OCLN mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of OCLN protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of OCLN mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of OCLN protein] CTD PMID:30266538 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [dictamnine co-treated with Oxygen deficiency] results in decreased phosphorylation of RPS6KB1 protein CTD PMID:30266538 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions
decreases expression
ISO dictamnine inhibits the reaction [Oxygen deficiency results in increased expression of SNAI2 protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH1 mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH1 protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH2 mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH2 protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of OCLN mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of OCLN protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of VIM mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of VIM protein]
dictamnine results in decreased expression of SNAI2 protein
CTD PMID:30266538 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Vim vimentin multiple interactions ISO [dictamnine co-treated with Oxygen deficiency] results in decreased expression of VIM protein; dictamnine promotes the reaction [HIF1A protein affects the expression of VIM mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of VIM protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of VIM mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of VIM protein] CTD PMID:30266538 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        antimicrobial agent 17469
          alkaloid antibiotic 275
            Dictamnine 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic molecule 19545
                              organic cyclic compound 19339
                                organic heterocyclic compound 18579
                                  organic heteropolycyclic compound 18039
                                    organic heterotricyclic compound 14640
                                      Dictamnine 15
paths to the root