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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dicloxacillin
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Accession:CHEBI:4511 term browser browse the term
Definition:A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]formyl group.
Synonyms:exact_synonym: 6beta-{[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carboxamido}-2,2-dimethylpenam-3alpha-carboxylic acid
 related_synonym: (2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;   Formula=C19H17Cl2N3O5S;   InChI=1S/C19H17Cl2N3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/t13-,14+,17-/m1/s1;   InChIKey=YFAGHNZHGGCZAX-JKIFEVAISA-N;   SMILES=[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c1c(C)onc1-c1c(Cl)cccc1Cl)C(O)=O;   dicloxacilina;   dicloxacilline;   dicloxacillinum
 xref: Beilstein:1233662;   CAS:3116-76-5;   DrugBank:DB00485;   Drug_Central:866;   KEGG:C06950;   KEGG:D02348;   LINCS:LSM-5234
 xref_mesh: MESH:D004009
 xref: PMID:26962156;   PMID:28721014;   PMID:29017833;   PMID:29105855;   PMID:29253094;   PMID:29504695;   Patent:GB978299;   Patent:US3239507;   Reaxys:1233662;   Wikipedia:Dicloxacillin
 cyclic_relationship: is_conjugate_acid_of CHEBI:52017


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dicloxacillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Dicloxacillin results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions
increases expression
ISO AGER protein affects the reaction [Dicloxacillin results in increased expression of GPT protein]
Dicloxacillin results in increased expression of AGER mRNA
CTD PMID:24747151 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression
ISO [Progesterone co-treated with Dicloxacillin] results in increased expression of CXCL2 mRNA
Dicloxacillin results in increased expression of CXCL2 mRNA
CTD PMID:22157104 PMID:24747151 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions
ISO Dicloxacillin results in increased expression of CXCL1 mRNA
Progesterone promotes the reaction [Dicloxacillin results in increased expression of CXCL1 mRNA]
CTD PMID:22157104 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO Dicloxacillin results in increased expression of and results in increased activity of CYP3A4 protein
Dicloxacillin results in increased expression of CYP3A4 mRNA
CTD PMID:18505790 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
ISO AGER protein affects the reaction [Dicloxacillin results in increased expression of GPT protein]; eritoran inhibits the reaction [Dicloxacillin results in increased expression of GPT protein] CTD PMID:24747151 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hmgb1 high mobility group box 1 increases expression ISO Dicloxacillin results in increased expression of HMGB1 protein CTD PMID:24747151 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Dicloxacillin results in increased expression of ICAM1 protein CTD PMID:14729754 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Dicloxacillin results in increased expression of IL1B mRNA CTD PMID:24747151 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 increases response to substance
increases expression
ISO IL4 results in increased susceptibility to Dicloxacillin
Dicloxacillin results in increased expression of IL4 protein
CTD PMID:21094227 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Dicloxacillin results in increased expression of NLRP3 mRNA CTD PMID:24747151 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Dicloxacillin results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Dicloxacillin results in increased expression of S100A8 mRNA CTD PMID:24747151 PMID:28138970 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Dicloxacillin results in increased expression of S100A9 mRNA CTD PMID:24747151 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        aetiopathogenetic role 19044
          allergen 17271
            penicillin 263
              dicloxacillin 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                lactam 8307
                                                  beta-lactam 795
                                                    beta-lactam antibiotic 780
                                                      penams 263
                                                        penicillanic acids 263
                                                          penicillanic acid 263
                                                            6-aminopenicillanic acid 263
                                                              penicillin 263
                                                                dicloxacillin 14
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