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ONTOLOGY REPORT - ANNOTATIONS
Term:pentamidine
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Accession:CHEBI:45081 term browser browse the term
Definition:A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Synonyms:exact_synonym: 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide
 related_synonym: 1,5-bis(4-amidinophenoxy)pentane;   4,4'-(1,5-pentanediylbis(oxy))bis-benzenecarboximidamide;   4,4'-(pentamethylenedioxy)dibenzamidine;   4,4'-Diamidinodiphenoxypentane;   Formula=C19H24N4O2;   InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);   InChIKey=XDRYMKDFEDOLFX-UHFFFAOYSA-N;   SMILES=C(CCCOC1=CC=C(C=C1)C(N)=N)COC2=CC=C(C=C2)C(N)=N;   p,p'-(pentamethylenedioxy)dibenzamidine;   pentamidin
 alt_id: CHEBI:45077;   CHEBI:7976
 xref: Beilstein:3159790 "ChemIDplus";   CAS:100-33-4 "ChemIDplus";   CAS:100-33-4 "KEGG COMPOUND";   DrugBank:DB00738;   Drug_Central:2090 "DrugCentral";   HMDB:HMDB0014876;   KEGG:C07420;   KEGG:D08333;   LINCS:LSM-4540
 xref_mesh: MESH:D010419
 xref: PDBeChem:PNT;   PMID:10415905 "Europe PMC";   PMID:10917591 "Europe PMC";   PMID:11438428 "Europe PMC";   PMID:11584934 "Europe PMC";   PMID:14603035 "Europe PMC";   PMID:15711592 "Europe PMC";   PMID:18346045 "Europe PMC";   PMID:18971316 "Europe PMC";   PMID:19966562 "Europe PMC";   PMID:20144237 "Europe PMC";   PMID:20599360 "Europe PMC";   PMID:22046004 "Europe PMC";   PMID:22093811 "Europe PMC";   PMID:22200378 "Europe PMC";   PMID:22327112 "Europe PMC";   PMID:26052915 "Europe PMC";   PMID:26117647 "Europe PMC";   PMID:26295040 "Europe PMC";   PMID:26344166 "Europe PMC";   PMID:26418240 "Europe PMC";   PMID:26431253 "Europe PMC";   PMID:26515653 "Europe PMC";   PMID:26606757 "Europe PMC";   PMID:26648589 "Europe PMC";   PMID:26734860 "Europe PMC";   PMID:26824946 "Europe PMC";   PMID:26828608 "Europe PMC";   PMID:26882015 "Europe PMC";   PMID:26903605 "Europe PMC";   PMID:26938448 "Europe PMC";   PMID:27011917 "Europe PMC";   PMID:27135970 "Europe PMC";   PMID:27164533 "Europe PMC";   PMID:27214074 "Europe PMC";   PMID:27297108 "Europe PMC";   PMID:27353022 "Europe PMC";   PMID:27357655 "Europe PMC";   PMID:27600039 "Europe PMC";   PMID:27729250 "Europe PMC";   PMID:28074607 "Europe PMC";   PMID:28167598 "Europe PMC";   PMID:28263303 "Europe PMC";   PMID:7542607 "Europe PMC";   PMID:7690919 "Europe PMC";   PMID:8841838 "Europe PMC";   Patent:EP975608;   Patent:GB507565;   Patent:US2006235001;   Patent:US2008167296;   Patent:US2008214569;   Patent:US2394003;   Patent:US7115665;   Reaxys:3159790 "Reaxys";   Wikipedia:Pentamidine
 cyclic_relationship: is_conjugate_base_of CHEBI:64383

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pentamidine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Asic5 acid sensing ion channel subunit family member 5 JBrowse link 2 180,935,392 180,964,365 RGD:6480464
G Asns asparagine synthetase (glutamine-hydrolyzing) JBrowse link 4 33,742,876 33,761,106 RGD:6480464
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Depp1 DEPP1, autophagy regulator JBrowse link 4 148,780,330 148,784,566 RGD:6480464
G Fabp1 fatty acid binding protein 1 JBrowse link 4 99,063,181 99,066,957 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Hpn hepsin JBrowse link 1 89,534,112 89,549,575 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Ifngr1 interferon gamma receptor 1 JBrowse link 1 15,062,380 15,080,815 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Inhbe inhibin subunit beta E JBrowse link 7 70,641,423 70,642,848 RGD:6480464
G Kat5 lysine acetyltransferase 5 JBrowse link 1 220,967,795 220,974,596 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Lss lanosterol synthase JBrowse link 20 12,844,522 12,870,474 RGD:6480464
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:6480464
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:6480464
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 JBrowse link 5 151,776,004 151,779,319 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:6480464
G Nupr1 nuclear protein 1, transcriptional regulator JBrowse link 1 194,767,484 194,769,519 RGD:6480464
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:6480464
G Serpina3m serine (or cysteine) proteinase inhibitor, clade A, member 3M JBrowse link 6 127,808,785 127,816,067 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc2a3 solute carrier family 2 member 3 JBrowse link 4 155,549,991 155,626,018 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Wipi1 WD repeat domain, phosphoinositide interacting 1 JBrowse link 10 97,859,730 97,896,949 RGD:6480464
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        xenobiotic 18178
          pentamidine 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            heteroorganic entity 19003
                              organochalcogen compound 18718
                                organooxygen compound 18629
                                  ether 15762
                                    polyether 233
                                      diether 101
                                        pentamidine 31
paths to the root

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