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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pentamidine
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Accession:CHEBI:45081 term browser browse the term
Definition:A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Synonyms:exact_synonym: 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide
 related_synonym: 1,5-bis(4-amidinophenoxy)pentane;   4,4'-(1,5-pentanediylbis(oxy))bis-benzenecarboximidamide;   4,4'-(pentamethylenedioxy)dibenzamidine;   4,4'-Diamidinodiphenoxypentane;   Formula=C19H24N4O2;   InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);   InChIKey=XDRYMKDFEDOLFX-UHFFFAOYSA-N;   SMILES=C(CCCOC1=CC=C(C=C1)C(N)=N)COC2=CC=C(C=C2)C(N)=N;   p,p'-(pentamethylenedioxy)dibenzamidine;   pentamidin
 alt_id: CHEBI:45077;   CHEBI:7976
 xref: Beilstein:3159790;   CAS:100-33-4;   DrugBank:DB00738;   Drug_Central:2090;   HMDB:HMDB0014876;   KEGG:C07420;   KEGG:D08333;   LINCS:LSM-4540
 xref_mesh: MESH:D010419
 xref: PDBeChem:PNT;   PMID:10415905;   PMID:10917591;   PMID:11438428;   PMID:11584934;   PMID:14603035;   PMID:15711592;   PMID:18346045;   PMID:18971316;   PMID:19966562;   PMID:20144237;   PMID:20599360;   PMID:22046004;   PMID:22093811;   PMID:22200378;   PMID:22327112;   PMID:26052915;   PMID:26117647;   PMID:26295040;   PMID:26344166;   PMID:26418240;   PMID:26431253;   PMID:26515653;   PMID:26606757;   PMID:26648589;   PMID:26734860;   PMID:26824946;   PMID:26828608;   PMID:26882015;   PMID:26903605;   PMID:26938448;   PMID:27011917;   PMID:27135970;   PMID:27164533;   PMID:27214074;   PMID:27297108;   PMID:27353022;   PMID:27357655;   PMID:27600039;   PMID:27729250;   PMID:28074607;   PMID:28167598;   PMID:28263303;   PMID:7542607;   PMID:7690919;   PMID:8841838;   Patent:EP975608;   Patent:GB507565;   Patent:US2006235001;   Patent:US2008167296;   Patent:US2008214569;   Patent:US2394003;   Patent:US7115665;   Reaxys:3159790;   Wikipedia:Pentamidine
 cyclic_relationship: is_conjugate_base_of CHEBI:64383

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pentamidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Pentamidine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Asic5 acid sensing ion channel subunit family member 5 decreases activity ISO Pentamidine results in decreased activity of ASIC5 protein CTD PMID:21828194 NCBI chr 2:180,935,392...180,964,365
Ensembl chr 2:180,936,688...180,964,365 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Pentamidine results in increased expression of ASNS mRNA CTD PMID:15342952 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163 		JBrowse link
G Atm ATM serine/threonine kinase affects localization
decreases activity		 ISO Pentamidine affects the localization of ATM protein modified form
Pentamidine results in decreased activity of ATM protein		 CTD PMID:20144237 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Pentamidine results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Pentamidine results in decreased activity of CYP2D6 protein CTD PMID:11124226 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO Pentamidine results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Pentamidine results in increased expression of DEPP1 mRNA CTD PMID:15342952 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562 		JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Pentamidine results in decreased expression of FABP1 mRNA CTD PMID:15342952 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Pentamidine results in increased expression of FNDC4 mRNA CTD PMID:15342952 NCBI chr 6:26,387,284...26,389,524 JBrowse link
G H2ax H2A.X variant histone affects localization ISO Pentamidine affects the localization of H2AX protein modified form CTD PMID:20144237 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hpn hepsin increases expression ISO Pentamidine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA		 CTD PMID:15588918 PMID:29594315 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO Pentamidine results in increased expression of IFNGR1 mRNA; Pentamidine results in increased expression of IFNGR1 protein CTD PMID:12803856 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907 		JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression		 ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL10 protein
Pentamidine results in decreased expression of IL10 protein		 CTD PMID:15588918 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Pentamidine results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA		 CTD PMID:15588918 PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein CTD PMID:15588918 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Pentamidine results in increased expression of INHBE mRNA CTD PMID:15342952 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169 		JBrowse link
G Kat5 lysine acetyltransferase 5 multiple interactions
decreases activity		 ISO Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein]
Pentamidine results in decreased activity of KAT5 protein		 CTD PMID:20144237 NCBI chr 1:220,967,795...220,974,596
Ensembl chr 1:220,967,796...220,974,597 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity		 ISO Pentamidine affects the localization of and affects the activity of KCNH2 protein; Pentamidine affects the localization of and results in decreased activity of KCNH2 protein; Pentamidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Pentamidine results in decreased activity of KCNH2 protein		 CTD PMID:15340016 PMID:15711590 PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G LOC299277 similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B increases expression ISO Pentamidine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 NCBI chr 6:127,871,895...127,888,287
Ensembl chr 6:127,872,666...127,886,540 		JBrowse link
G Lss lanosterol synthase decreases expression ISO Pentamidine results in decreased expression of LSS mRNA CTD PMID:15342952 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases activity ISO Pentamidine results in decreased activity of MRE11 protein CTD PMID:20144237 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489 		JBrowse link
G Nbn nibrin affects localization ISO Pentamidine affects the localization of NBN protein CTD PMID:20144237 NCBI chr 5:29,622,347...29,656,877
Ensembl chr 5:29,622,281...29,656,864 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Pentamidine results in increased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Pentamidine results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Pentamidine results in increased expression of NUPR1 mRNA CTD PMID:15342952 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524 		JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Pentamidine affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Pentamidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Pentamidine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein] CTD PMID:20144237 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Pentamidine results in increased expression of WIPI1 mRNA CTD PMID:15342952 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525 		JBrowse link
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  CHEBI ontology 19875
    role 19825
      biological role 19825
        xenobiotic 18454
          pentamidine 33
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  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            heteroorganic entity 19248
                              organochalcogen compound 18956
                                organooxygen compound 18879
                                  ether 16108
                                    polyether 247
                                      diether 108
                                        pentamidine 33
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