CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: pentamidine
Accession: CHEBI:45081
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Definition: A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Synonyms: exact_synonym: 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide
related_synonym: 1,5-bis(4-amidinophenoxy)pentane; 4,4'-(1,5-pentanediylbis(oxy))bis-benzenecarboximidamide; 4,4'-(pentamethylenedioxy)dibenzamidine; 4,4'-Diamidinodiphenoxypentane; Formula=C19H24N4O2; InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23); InChIKey=XDRYMKDFEDOLFX-UHFFFAOYSA-N; SMILES=C(CCCOC1=CC=C(C=C1)C(N)=N)COC2=CC=C(C=C2)C(N)=N; p,p'-(pentamethylenedioxy)dibenzamidine; pentamidin
alt_id: CHEBI:45077; CHEBI:7976
xref: Beilstein:3159790; CAS:100-33-4; DrugBank:DB00738; Drug_Central:2090; HMDB:HMDB0014876; KEGG:C07420; KEGG:D08333; LINCS:LSM-4540
xref_mesh: MESH:D010419
xref: PDBeChem:PNT; PMID:10415905; PMID:10917591; PMID:11438428; PMID:11584934; PMID:14603035; PMID:15711592; PMID:18346045; PMID:18971316; PMID:19966562; PMID:20144237; PMID:20599360; PMID:22046004; PMID:22093811; PMID:22200378; PMID:22327112; PMID:26052915; PMID:26117647; PMID:26295040; PMID:26344166; PMID:26418240; PMID:26431253; PMID:26515653; PMID:26606757; PMID:26648589; PMID:26734860; PMID:26824946; PMID:26828608; PMID:26882015; PMID:26903605; PMID:26938448; PMID:27011917; PMID:27135970; PMID:27164533; PMID:27214074; PMID:27297108; PMID:27353022; PMID:27357655; PMID:27600039; PMID:27729250; PMID:28074607; PMID:28167598; PMID:28263303; PMID:7542607; PMID:7690919; PMID:8841838; Patent:EP975608; Patent:GB507565; Patent:US2006235001; Patent:US2008167296; Patent:US2008214569; Patent:US2394003; Patent:US7115665; Reaxys:3159790; Wikipedia:Pentamidine
cyclic_relationship: is_conjugate_base_of CHEBI:64383
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Ar
androgen receptor
multiple interactions
ISO
Pentamidine binds to and results in decreased activity of AR protein
CTD
PMID:25752796
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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Asic5
acid sensing ion channel subunit family member 5
decreases activity
ISO
Pentamidine results in decreased activity of ASIC5 protein
CTD
PMID:21828194
NCBI chr 2:180,935,392...180,964,365
Ensembl chr 2:180,936,688...180,964,365
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Asns
asparagine synthetase (glutamine-hydrolyzing)
increases expression
ISO
Pentamidine results in increased expression of ASNS mRNA
CTD
PMID:15342952
NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
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Atm
ATM serine/threonine kinase
affects localization decreases activity
ISO
Pentamidine affects the localization of ATM protein modified form Pentamidine results in decreased activity of ATM protein
CTD
PMID:20144237
NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
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Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
decreases activity
ISO
Pentamidine results in decreased activity of CYP2C19 protein
CTD
PMID:11124226
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity
ISO
Pentamidine results in decreased activity of CYP2D6 protein
CTD
PMID:11124226
NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
decreases activity
ISO
Pentamidine results in decreased activity of CYP3A4 protein
CTD
PMID:11124226
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Depp1
DEPP1, autophagy regulator
increases expression
ISO
Pentamidine results in increased expression of DEPP1 mRNA
CTD
PMID:15342952
NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
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Fabp1
fatty acid binding protein 1
decreases expression
ISO
Pentamidine results in decreased expression of FABP1 mRNA
CTD
PMID:15342952
NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
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Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Pentamidine results in increased expression of FNDC4 mRNA
CTD
PMID:15342952
NCBI chr 6:26,387,284...26,389,524
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H2ax
H2A.X variant histone
affects localization
ISO
Pentamidine affects the localization of H2AX protein modified form
CTD
PMID:20144237
NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
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Hpn
hepsin
increases expression
ISO
Pentamidine results in increased expression of HPN mRNA
CTD
PMID:15342952
NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
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Ifng
interferon gamma
multiple interactions
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD
PMID:15588918 PMID:29594315
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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Ifngr1
interferon gamma receptor 1
increases expression
ISO
Pentamidine results in increased expression of IFNGR1 mRNA; Pentamidine results in increased expression of IFNGR1 protein
CTD
PMID:12803856
NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
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Il10
interleukin 10
multiple interactions decreases expression
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL10 protein Pentamidine results in decreased expression of IL10 protein
CTD
PMID:15588918
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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Il1b
interleukin 1 beta
decreases expression
ISO
Pentamidine results in decreased expression of IL1B mRNA
CTD
PMID:29594315
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il2
interleukin 2
multiple interactions
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD
PMID:15588918 PMID:29594315
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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Il4
interleukin 4
multiple interactions
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein
CTD
PMID:15588918
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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Inhbe
inhibin subunit beta E
increases expression
ISO
Pentamidine results in increased expression of INHBE mRNA
CTD
PMID:15342952
NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
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Kat5
lysine acetyltransferase 5
multiple interactions decreases activity
ISO
Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein] Pentamidine results in decreased activity of KAT5 protein
CTD
PMID:20144237
NCBI chr 1:220,967,795...220,974,596
Ensembl chr 1:220,967,796...220,974,597
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions decreases activity
ISO
Pentamidine affects the localization of and affects the activity of KCNH2 protein; Pentamidine affects the localization of and results in decreased activity of KCNH2 protein; Pentamidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Pentamidine results in decreased activity of KCNH2 protein
CTD
PMID:15340016 PMID:15711590 PMID:21158687
NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
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LOC299277
similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B
increases expression
ISO
Pentamidine results in increased expression of SERPINA3 mRNA
CTD
PMID:15342952
NCBI chr 6:127,871,895...127,888,287
Ensembl chr 6:127,872,666...127,886,540
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Lss
lanosterol synthase
decreases expression
ISO
Pentamidine results in decreased expression of LSS mRNA
CTD
PMID:15342952
NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
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Mre11
MRE11 homolog, double strand break repair nuclease
decreases activity
ISO
Pentamidine results in decreased activity of MRE11 protein
CTD
PMID:20144237
NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
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Nbn
nibrin
affects localization
ISO
Pentamidine affects the localization of NBN protein
CTD
PMID:20144237
NCBI chr 5:29,622,347...29,656,877
Ensembl chr 5:29,622,281...29,656,864
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Pentamidine results in increased expression of NR0B2 mRNA
CTD
PMID:15342952
NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
increases activity
ISO
Pentamidine results in increased activity of NR1H4 protein
CTD
PMID:22414727
NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
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Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
Pentamidine results in increased expression of NUPR1 mRNA
CTD
PMID:15342952
NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
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RT1-Bb
RT1 class II, locus Bb
affects expression
ISO
Pentamidine affects the expression of HLA-DQB1 mRNA
CTD
PMID:25811541
NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Pentamidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
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Slc2a3
solute carrier family 2 member 3
decreases expression
ISO
Pentamidine results in decreased expression of SLC2A3 mRNA
CTD
PMID:15342952
NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
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Tp53
tumor protein p53
multiple interactions
ISO
Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein]
CTD
PMID:20144237
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Pentamidine results in increased expression of WIPI1 mRNA
CTD
PMID:15342952
NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
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