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ONTOLOGY REPORT - ANNOTATIONS


Term:diazoxide
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Accession:CHEBI:4495 term browser browse the term
Definition:A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Synonyms:exact_synonym: 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
 related_synonym: Diazossido;   Eudemine;   Formula=C8H7ClN2O2S;   InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11);   InChIKey=GDLBFKVLRPITMI-UHFFFAOYSA-N;   SMILES=CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1;   diazoxido;   diazoxidum
 alt_id: CHEBI:6046
 xref: Beilstein:523907 "Beilstein";   CAS:364-98-7 "ChemIDplus";   DrugBank:DB01119;   Drug_Central:854 "DrugCentral";   HMDB:HMDB0015251;   KEGG:C06949;   KEGG:D00294;   LINCS:LSM-3639
 xref_mesh: MESH:D003981
 xref: PMID:11014217 "Europe PMC";   PMID:12039709 "Europe PMC";   PMID:15319354 "Europe PMC";   PMID:16740260 "Europe PMC";   PMID:16777075 "Europe PMC";   PMID:18191077 "Europe PMC";   PMID:20828743 "Europe PMC";   PMID:20950601 "Europe PMC";   PMID:21538163 "Europe PMC";   PMID:21693179 "Europe PMC";   PMID:22047130 "Europe PMC";   PMID:29438107 "Europe PMC";   Patent:DE723278;   Patent:US2986573;   Patent:US3345365;   Reaxys:523907 "Reaxys";   Wikipedia:Diazoxide


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diazoxide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aifm1 apoptosis inducing factor, mitochondria associated 1 JBrowse link X 135,304,063 135,343,062 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:6480464
G Gcg glucagon JBrowse link 3 48,442,635 48,451,650 RGD:6480464
G Gpd2 glycerol-3-phosphate dehydrogenase 2 JBrowse link 3 43,223,892 43,359,069 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Iapp islet amyloid polypeptide JBrowse link 4 176,509,863 176,517,903 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 JBrowse link 1 102,103,093 102,107,134 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464
G Nampt nicotinamide phosphoribosyltransferase JBrowse link 6 52,122,085 52,156,473 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Pdx1 pancreatic and duodenal homeobox 1 JBrowse link 12 9,496,044 9,501,211 RGD:6480464
G Slc2a2 solute carrier family 2 member 2 JBrowse link 2 114,413,427 114,445,418 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            diuretic 967
              diazoxide 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organonitrogen heterocyclic compound 16961
                                    thiazide 74
                                      benzothiadiazine 74
                                        diazoxide 25
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.