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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:propofol
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Accession:CHEBI:44915 term browser browse the term
Definition:A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Synonyms:related_synonym: 2,6-BIS(1-METHYLETHYL)PHENOL;   2,6-Diisopropylphenol;   2,6-bis(propan-2-yl)phenol;   Diprivan;   Disoprivan;   Disoprofol;   Rapinovet;   propofolum
 alt_id: CHEBI:44914;   CHEBI:8495
 xref: Beilstein:1866484;   CAS:2078-54-8;   DrugBank:DB00818
 xref_mesh: MESH:D015742
 xref: VSDB:1846;   drugcentral:2302;   kegg.compound:C07523;   kegg.drug:D00549;   lincs.smallmolecule:LSM-3847;   pdb-ccd:PFL;   wikipedia.en:Propofol
 chemrof_formula: C12H18O
 chemrof_smiles: CC(C)c1cccc(C(C)C)c1O
 chemrof_inchi: InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
 chemrof_inchikey: OLBCVFGFOZPWHH-UHFFFAOYSA-N


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propofol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd11-as1 ABHD11 antisense RNA 1 increases expression ISO Propofol results in increased expression of BICDL3P mRNA CTD PMID:35238236 NCBI chr12:27,317,656...27,318,643 JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions EXP HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]]; Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]] CTD PMID:24810525 NCBI chr19:68,781,168...68,784,194
Ensembl chr19:68,781,168...68,786,178 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation 		EXP
ISO 		Propofol promotes the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]
Propofol results in increased phosphorylation of AKT1 protein
Propofol results in decreased phosphorylation of AKT1 protein
CASC9 protein inhibits the reaction [Propofol results in decreased phosphorylation of AKT1 protein] 		CTD PMID:24810525 PMID:35238236 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression
multiple interactions 		EXP Propofol results in decreased expression of APAF1 protein
Propofol inhibits the reaction [Doxorubicin results in increased expression of APAF1 protein] 		CTD PMID:21468576 PMID:22015447 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein multiple interactions
decreases expression 		EXP Bicuculline inhibits the reaction [Propofol results in decreased expression of ARC protein] CTD PMID:18946287 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220 		JBrowse link
G Avp arginine vasopressin multiple interactions ISO [Propofol co-treated with desflurane] results in increased expression of AVP protein CTD PMID:8017643 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression 		EXP
ISO 		[Resveratrol co-treated with Propofol] results in decreased expression of BAX; NUFIP1 protein affects the reaction [Propofol results in increased expression of BAX protein]; PEA15 protein inhibits the reaction [Propofol results in increased expression of BAX protein]; Propofol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]
Propofol results in decreased expression of BAX
[NUFIP1 affects the susceptibility to Propofol] which affects the expression of BAX protein; Acetylcysteine inhibits the reaction [Propofol results in increased expression of BAX protein] 		CTD PMID:21786383 PMID:22015447 PMID:23353162 PMID:28804952 PMID:31257496 More... NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
decreases expression 		EXP
ISO 		Propofol results in increased expression of BCL2; Propofol results in increased expression of BCL2 mRNA; Propofol results in increased expression of BCL2 protein
[Resveratrol co-treated with Propofol] results in increased expression of BCL2; NUFIP1 protein affects the reaction [Propofol results in decreased expression of BCL2 protein]; PEA15 protein inhibits the reaction [Propofol results in decreased expression of BCL2 protein]; Propofol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Propofol inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; Wortmannin inhibits the reaction [Propofol results in increased expression of BCL2 protein]
[NUFIP1 affects the susceptibility to Propofol] which affects the expression of BCL2 protein; Acetylcysteine inhibits the reaction [Propofol results in decreased expression of BCL2 protein] 		CTD PMID:19703415 PMID:21786383 PMID:22015447 PMID:23353162 PMID:24810525 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP Propofol results in decreased expression of BCL2L1 mRNA; Propofol results in decreased expression of BCL2L1 protein CTD PMID:26254736 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions 		ISO Propofol results in increased expression of BECN1 protein
MIR138 promotes the reaction [Propofol results in increased expression of BECN1 protein] 		CTD PMID:39441175 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Blacat1 BLACAT1 overlapping LEMD1 locus increases expression ISO Propofol results in increased expression of BLACAT1 mRNA CTD PMID:35238236 NCBI chr13:46,189,091...46,202,506
Ensembl chr13:46,197,208...46,197,306 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of BNIP3 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of BNIP3 protein] CTD PMID:21307008 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962 		JBrowse link
G C17h10orf67 similar to human chromosome 10 open reading frame 67 increases expression ISO Propofol results in increased expression of C10ORF67 mRNA CTD PMID:35238236 NCBI chr17:86,970,801...87,082,723
Ensembl chr17:86,980,186...87,082,700 		JBrowse link
G C1h10orf143 similar to human chromosome 10 open reading frame 143 decreases expression ISO Propofol results in decreased expression of C10ORF143 mRNA CTD PMID:35238236 NCBI chr 1:201,614,151...201,654,142
Ensembl chr 1:201,561,396...201,652,127 		JBrowse link
G C3 complement C3 multiple interactions ISO [Triglycerides co-treated with Propofol] results in increased expression of C3 protein modified form CTD PMID:15983144 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G Ca1 carbonic anhydrase 1 decreases activity ISO Propofol analog results in decreased activity of CA1 protein; Propofol results in decreased activity of CA1 protein CTD PMID:19231207 NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454 		JBrowse link
G Ca5a carbonic anhydrase 5A decreases expression ISO Propofol results in decreased expression of CA5A mRNA CTD PMID:35238236 NCBI chr19:66,881,678...66,911,486
Ensembl chr19:66,881,693...66,911,486 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Propofol CTD PMID:15644869 NCBI chr 7:113,716,266...113,827,670
Ensembl chr 7:113,716,266...113,827,670 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Propofol analog results in decreased activity of CA2 protein; Propofol results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
decreases expression
increases expression
increases cleavage 		EXP
ISO 		1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole promotes the reaction [Propofol results in increased cleavage of CASP3 protein]; [Resveratrol co-treated with Propofol] results in decreased expression of CASP3; calpeptin inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; hyperforin inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]; NUFIP1 protein inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]; PEA15 protein inhibits the reaction [Propofol results in decreased expression of CASP3 protein]; PEA15 protein inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]; Propofol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]; Propofol inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Propofol inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]
Propofol results in increased activity of CASP3 protein
Propofol results in decreased expression of CASP3; Propofol results in decreased expression of CASP3 protein
Propofol results in increased expression of CASP3 protein modified form
Acetylcysteine inhibits the reaction [Propofol results in increased cleavage of CASP3 protein] 		CTD PMID:17640472 PMID:21786383 PMID:22015447 PMID:23353162 PMID:24810525 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 decreases cleavage
increases activity
increases cleavage
multiple interactions 		EXP
ISO 		Propofol results in decreased cleavage of CASP9 protein
Propofol results in increased activity of CASP9 protein
Propofol results in increased cleavage of CASP9 protein
Acetylcysteine inhibits the reaction [Propofol results in increased cleavage of CASP9 protein] 		CTD PMID:21468576 PMID:21786383 PMID:28804952 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase increases expression
multiple interactions
decreases activity 		ISO
EXP 		Propofol results in increased expression of CAT protein
Acetylcysteine inhibits the reaction [Propofol results in decreased activity of CAT protein] 		CTD PMID:16938161 PMID:21468576 PMID:28804952 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccdc196 coiled-coil domain containing 196 affects expression ISO Propofol affects the expression of CCDC196 mRNA CTD PMID:35238236 NCBI chr 6:102,646,156...102,672,145
Ensembl chr 6:102,648,953...102,664,225 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Propofol results in decreased expression of CCNB1 protein CTD PMID:28804952 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Propofol results in increased expression of CCND1 protein CTD PMID:28804952 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cd68 Cd68 molecule increases expression
multiple interactions 		ISO Propofol results in increased expression of CD68 mRNA
Lipopolysaccharides inhibits the reaction [Propofol results in increased expression of CD68 mRNA] 		CTD PMID:35953652 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Propofol affects the reaction [LINC01133 affects the expression of CDH1 protein] CTD PMID:38146619 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdh11 cadherin 11 multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in decreased expression of CDH11 mRNA] CTD PMID:35953652 NCBI chr19:2,152,961...2,312,140
Ensembl chr19:2,154,840...2,312,140 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO Propofol affects the reaction [LINC01133 affects the expression of CDH2 protein] CTD PMID:38146619 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions 		ISO Propofol results in decreased expression of CDK1 protein
[Propofol results in increased susceptibility to STA 9090] which results in decreased expression of CDK1 protein 		CTD PMID:24784839 PMID:28804952 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions
increases expression 		EXP Dexmedetomidine inhibits the reaction [Propofol results in increased expression of CDK5R1 protein] CTD PMID:31187143 NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions EXP Propofol inhibits the reaction [Acetylcholine results in increased activity of CHRM1 protein]; Propofol inhibits the reaction [Scopolamine Derivatives results in increased activity of CHRM1 protein] CTD PMID:14534362 NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions 		EXP Propofol results in decreased phosphorylation of CREB1 protein
PEA15 protein inhibits the reaction [Propofol results in decreased phosphorylation of CREB1 protein] 		CTD PMID:31257496 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Propofol results in decreased expression of CXCL12 protein CTD PMID:36207479 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA] CTD PMID:21307008 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Propofol results in decreased expression of CXCR4 protein CTD PMID:36207479 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Propofol results in increased expression of CYCS protein CTD PMID:21786383 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Propofol CTD PMID:15769884 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Dio3os DIO3 opposite strand upstream RNA decreases expression ISO Propofol results in decreased expression of DIO3OS mRNA CTD PMID:35238236
G Dlg4 discs large MAGUK scaffold protein 4 increases expression
multiple interactions 		EXP Propofol results in increased expression of DLG4 protein
NUFIP1 protein affects the reaction [Propofol results in increased expression of DLG4 protein] 		CTD PMID:38599287 NCBI chr10:55,239,397...55,267,780
Ensembl chr10:55,236,869...55,265,839 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases phosphorylation
multiple interactions 		EXP Propofol results in increased phosphorylation of DPYSL2 protein
Dexmedetomidine inhibits the reaction [Propofol results in increased phosphorylation of DPYSL2 protein] 		CTD PMID:31187143 NCBI chr15:45,181,041...45,287,065
Ensembl chr15:45,181,041...45,287,065 		JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions 		EXP
ISO 		Propofol results in decreased expression of EDN1 protein
Propofol inhibits the reaction [EDN1 protein affects the transport of Calcium] 		CTD PMID:9138053 PMID:17470888 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [Propofol results in increased susceptibility to STA 9090] which results in decreased expression of EGFR protein CTD PMID:24784839 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Ephb2 Eph receptor B2 increases expression ISO Propofol results in increased expression of EPHB2 mRNA CTD PMID:35953652 NCBI chr 5:154,179,065...154,360,459
Ensembl chr 5:154,179,065...154,360,615 		JBrowse link
G Ewsr1 EWS RNA-binding protein 1 increases expression ISO Propofol results in increased expression of EWSR1 mRNA CTD PMID:35953652 NCBI chr14:84,179,413...84,208,149
Ensembl chr14:84,179,618...84,208,095 		JBrowse link
G Fam95c family with sequence similarity 95 member C decreases expression ISO Propofol results in decreased expression of FAM95C mRNA CTD PMID:35238236 NCBI chr17:59,376,110...59,416,150
Ensembl chr17:59,376,114...59,415,809 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Propofol results in increased expression of FAS protein CTD PMID:21786383 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Fendrr FOXF1 adjacent non-coding developmental regulatory RNA decreases expression ISO Propofol results in decreased expression of FENDRR mRNA CTD PMID:35238236 NCBI chr19:66,035,910...66,061,466
Ensembl chr19:66,036,856...66,044,268 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Propofol results in increased expression of FN1 mRNA CTD PMID:35953652 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression 		EXP Lidocaine inhibits the reaction [Propofol results in increased expression of FOS protein]
Propofol results in increased expression of FOS mRNA; Propofol results in increased expression of FOS protein 		CTD PMID:10781476 PMID:17136530 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions
increases expression 		ISO FOXO1 protein affects the reaction [Propofol results in increased expression of LINC01133 mRNA]
Propofol results in increased expression of FOXO1 mRNA; Propofol results in increased expression of FOXO1 protein 		CTD PMID:38146619 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO
EXP 		[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Propofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] 		CTD PMID:9316872 PMID:10049148 PMID:11399263 PMID:12939268 PMID:22029276 More... NCBI chr10:27,096,731...27,152,563
Ensembl chr10:27,096,740...27,152,442 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Propofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3] CTD PMID:29038840 NCBI chr14:37,451,218...37,587,458
Ensembl chr14:37,450,683...37,587,457 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression ISO Propofol results in increased expression of GABRA4 mRNA CTD PMID:16733821 NCBI chr14:36,944,747...37,021,652
Ensembl chr14:36,944,388...37,021,648 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO Propofol results in increased activity of [GABRA6 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form] CTD PMID:29038840 NCBI chr10:27,311,965...27,327,337
Ensembl chr10:27,311,979...27,327,234 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form] CTD PMID:10049148 PMID:29038840 NCBI chr14:36,434,339...36,917,920
Ensembl chr14:36,434,352...36,902,893 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance
multiple interactions 		EXP
ISO 		GABRB2 protein affects the susceptibility to Propofol
Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Propofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]
Propofol results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB2 binds to GABRG2 protein alternative form] 		CTD PMID:11399263 PMID:12939268 PMID:29038840 NCBI chr10:27,438,127...27,657,680
Ensembl chr10:27,438,238...27,655,171 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO [Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3]; Propofol results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form] CTD PMID:9316872 PMID:22029276 PMID:29038840 NCBI chr 1:117,602,772...117,838,230
Ensembl chr 1:117,431,842...117,836,725 		JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon multiple interactions
decreases response to substance 		ISO
EXP 		Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]
GABRE protein results in decreased susceptibility to Propofol 		CTD PMID:9039914 PMID:10049148 NCBI chr  X:155,102,078...155,120,821
Ensembl chr  X:155,102,083...155,120,735 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO
EXP 		[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Propofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] 		CTD PMID:9316872 PMID:10049148 PMID:11399263 PMID:12939268 PMID:22029276 More... NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,876,926...26,965,523 		JBrowse link
G Gas5 growth arrest specific 5 increases expression ISO Propofol results in increased expression of GAS5 mRNA CTD PMID:35238236 NCBI chr13:75,836,963...75,840,284 JBrowse link
G Gcnt4 glucosaminyl (N-acetyl) transferase 4 increases expression ISO Propofol results in increased expression of GCNT4 mRNA CTD PMID:35238236 NCBI chr 2:29,987,944...30,017,708
Ensembl chr 2:29,984,327...30,017,982 		JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression ISO Propofol results in decreased expression of GLUD1 protein CTD PMID:36207479 NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,646,509...9,680,210 		JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression ISO Propofol results in decreased expression of GNAI2 mRNA CTD PMID:35238236 NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 increases expression
multiple interactions 		ISO Propofol results in increased expression of GNRH1 mRNA
Lipopolysaccharides promotes the reaction [Propofol results in increased expression of GNRH1 mRNA] 		CTD PMID:35953652 NCBI chr15:46,147,878...46,152,086
Ensembl chr15:46,148,301...46,148,977
Ensembl chr15:46,148,301...46,148,977 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression
multiple interactions 		EXP Propofol results in increased expression of GRIA2 protein
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Propofol results in increased expression of GRIA2 protein] 		CTD PMID:28663055 NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:168,247,496...168,367,616 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects response to substance ISO GRIN2A protein affects the susceptibility to Propofol CTD PMID:15731593 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Dexmedetomidine inhibits the reaction [Propofol results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Propofol results in decreased phosphorylation of and results in increased activity of GSK3B protein CTD PMID:31187143 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G H19 H19 imprinted maternally expressed transcript decreases expression ISO Propofol results in decreased expression of H19 mRNA CTD PMID:35238236 NCBI chr 1:207,160,175...207,162,851 JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of HGF mRNA] CTD PMID:35953652 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression 		ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A protein]
Propofol results in decreased expression of HIF1A protein 		CTD PMID:21307008 PMID:36207479 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions 		EXP Propofol results in increased expression of HMOX1 protein
HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]; Propofol inhibits the reaction [Streptozocin results in decreased activity of HMOX1 protein]; Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]] 		CTD PMID:21468576 PMID:24810525 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hpse heparanase increases expression
multiple interactions 		ISO Propofol results in increased expression of HPSE mRNA
Lipopolysaccharides promotes the reaction [Propofol results in increased expression of HPSE mRNA] 		CTD PMID:35953652 NCBI chr14:9,200,971...9,241,377
Ensembl chr14:9,188,275...9,241,754 		JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 multiple interactions
increases expression 		ISO Lipopolysaccharides promotes the reaction [Propofol results in increased expression of HTATIP2 mRNA] CTD PMID:35953652 NCBI chr 1:108,609,424...108,624,810
Ensembl chr 1:108,605,811...108,624,815 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO Propofol results in increased expression of IGF1 mRNA CTD PMID:35953652 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764 		JBrowse link
G Igsf9b immunoglobulin superfamily, member 9B decreases expression ISO Propofol results in decreased expression of IGSF9B mRNA CTD PMID:35238236 NCBI chr 8:33,971,779...34,027,390
Ensembl chr 8:33,971,779...34,018,128 		JBrowse link
G Il10 interleukin 10 increases expression ISO Propofol results in increased expression of IL10 protein CTD PMID:17032661 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression 		ISO Lipopolysaccharides promotes the reaction [Propofol results in increased expression of IL18 mRNA] CTD PMID:35953652 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression 		ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Propofol results in decreased expression of IL1B mRNA 		CTD PMID:35953652 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases secretion ISO Propofol results in decreased secretion of IL2RA protein CTD PMID:16119599 NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions 		ISO Propofol results in decreased expression of IL6 protein
Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] 		CTD PMID:17032661 PMID:21307008 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO Propofol decreases phosphorylation of JAK2 protein in colon epithelium RGD PMID:32386021 RGD:125097524 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Propofol results in increased expression of JUN mRNA CTD PMID:10781476 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Kng1 kininogen 1 multiple interactions ISO [Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form; [Triglycerides co-treated with Propofol] results in increased expression of KNG1 protein modified form; Lidocaine inhibits the reaction [[Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form]; nafamostat inhibits the reaction [[Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form] CTD PMID:10655909 PMID:15983144 NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148 		JBrowse link
G Ldha lactate dehydrogenase A increases activity ISO Propofol increases activity of LDHA protein in colon epithelium RGD PMID:32386021 RGD:125097524 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Lrcol1 leucine rich colipase-like 1 decreases expression ISO Propofol results in decreased expression of LRCOL1 mRNA CTD PMID:35238236 NCBI chr12:51,985,786...51,999,282
Ensembl chr12:51,985,814...51,997,688 		JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 increases expression ISO Propofol results in increased expression of LRG1 mRNA CTD PMID:21786383 NCBI chr 9:1,034,691...1,036,937
Ensembl chr 9:1,034,679...1,037,337 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO MIR138 promotes the reaction [Propofol results in increased lipidation of and results in increased localization of MAP1LC3B protein]; Propofol results in increased lipidation of and results in increased localization of MAP1LC3B protein CTD PMID:39441175 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein] CTD PMID:19573522 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K2 protein] CTD PMID:19573522 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation 		ISO
EXP 		Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]
Propofol results in decreased phosphorylation of MAPK1 protein
PEA15 protein inhibits the reaction [Propofol results in decreased phosphorylation of MAPK1 protein] 		CTD PMID:19573522 PMID:31257496 PMID:36207479 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation 		ISO
EXP 		Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]
Propofol results in decreased phosphorylation of MAPK3 protein
PEA15 protein inhibits the reaction [Propofol results in decreased phosphorylation of MAPK3 protein] 		CTD PMID:19573522 PMID:31257496 PMID:36207479 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions
increases expression 		ISO Lipopolysaccharides promotes the reaction [Propofol results in increased expression of MET mRNA] CTD PMID:35953652 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821 		JBrowse link
G Mgat5 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase multiple interactions
increases expression 		ISO Lipopolysaccharides promotes the reaction [Propofol results in increased expression of MGAT5 mRNA] CTD PMID:35953652 NCBI chr13:41,228,327...41,516,462
Ensembl chr13:41,228,360...41,516,461 		JBrowse link
G Mir1224 microRNA 1224 increases expression EXP Propofol results in increased expression of MIR1224 mRNA CTD PMID:26254736 NCBI chr11:93,811,291...93,811,375 JBrowse link
G Mir138-1 microRNA 138-1 increases expression
multiple interactions 		ISO Propofol results in increased expression of MIR138
MIR138 promotes the reaction [Propofol results in decreased expression of SIRT1 protein]; MIR138 promotes the reaction [Propofol results in decreased expression of SQSTM1 protein]; MIR138 promotes the reaction [Propofol results in increased expression of BECN1 protein]; MIR138 promotes the reaction [Propofol results in increased lipidation of and results in increased localization of MAP1LC3B protein] 		CTD PMID:39441175 NCBI chr 8:131,178,434...131,178,532
Ensembl chr 8:131,178,434...131,178,532 		JBrowse link
G Mir146a microRNA 146a decreases expression EXP Propofol results in decreased expression of MIR146A mRNA CTD PMID:26254736 NCBI chr10:28,349,996...28,350,090 JBrowse link
G Mir146b microRNA 146b decreases expression EXP Propofol results in decreased expression of MIR146B mRNA CTD PMID:26254736 NCBI chr 1:255,144,860...255,144,947
Ensembl chr 1:255,144,860...255,144,947 		JBrowse link
G Mir155 microRNA 155 decreases expression EXP Propofol results in decreased expression of MIR155 mRNA CTD PMID:26254736 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:37,261,114...37,261,178 		JBrowse link
G Mir186 microRNA 186 multiple interactions ISO Propofol affects the reaction [LINC01133 affects the expression of MIR186 mRNA]; Propofol inhibits the reaction [MIR186 results in decreased expression of NR3C2 protein] CTD PMID:38146619 NCBI chr 2:249,241,650...249,241,735
Ensembl chr 2:249,241,650...249,241,735 		JBrowse link
G Mir221 microRNA 221 decreases expression EXP Propofol results in decreased expression of MIR221 mRNA CTD PMID:26254736 NCBI chr  X:6,023,182...6,023,290
Ensembl chr  X:6,023,182...6,023,290 		JBrowse link
G Mir222 microRNA 222 decreases expression EXP Propofol results in decreased expression of MIR222 mRNA CTD PMID:26254736 NCBI chr  X:6,022,621...6,022,723
Ensembl chr  X:6,022,621...6,022,723 		JBrowse link
G Mir27b microRNA 27b increases expression EXP Propofol results in increased expression of MIR27B mRNA CTD PMID:26254736 NCBI chr17:1,819,147...1,819,243 JBrowse link
G Mir3473 microRNA 3473 increases expression EXP Propofol results in increased expression of MIR3473 mRNA CTD PMID:26254736 NCBI chr13:42,051,691...42,051,757
Ensembl chr13:42,051,691...42,051,757 		JBrowse link
G Mir378 microRNA 378 increases expression EXP Propofol results in increased expression of MIR378 mRNA CTD PMID:26254736 NCBI chr18:57,128,922...57,128,986 JBrowse link
G Mir6215 microRNA 6215 increases expression EXP Propofol results in increased expression of MIR6215 mRNA CTD PMID:26254736 NCBI chr 5:157,133,945...157,134,011 JBrowse link
G Mir665 microRNA 665 increases expression EXP Propofol results in increased expression of MIR665 mRNA CTD PMID:26254736 NCBI chr 6:134,321,679...134,321,772
Ensembl chr 6:134,321,679...134,321,772 		JBrowse link
G Mir99a microRNA 99a increases expression EXP Propofol results in increased expression of MIR99A mRNA CTD PMID:26254736 NCBI chr11:29,687,392...29,687,472
Ensembl chr11:29,687,392...29,687,472 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Propofol results in decreased expression of MKI67 protein CTD PMID:36207479 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression 		ISO Lipopolysaccharides inhibits the reaction [Propofol results in decreased expression of MMP2 mRNA] CTD PMID:35953652 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp24os MMP24 opposite strand decreases expression ISO Propofol results in decreased expression of MMP24OS mRNA CTD PMID:35238236 NCBI chr 3:164,783,060...164,784,573
Ensembl chr 3:164,783,060...164,784,573 		JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions
increases expression 		ISO Lipopolysaccharides promotes the reaction [Propofol results in increased expression of MMP7 mRNA] CTD PMID:35953652 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755 		JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 decreases expression ISO Propofol results in decreased expression of MPC1 protein CTD PMID:36207479 NCBI chr 1:54,985,305...54,996,979
Ensembl chr 1:54,985,301...54,997,064 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions 		ISO Propofol results in decreased phosphorylation of MTOR protein
CASC9 protein inhibits the reaction [Propofol results in decreased phosphorylation of MTOR protein] 		CTD PMID:35238236 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Propofol inhibits the reaction [Halothane results in increased phosphorylation of NFKBIA protein] CTD PMID:16965849 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP Bicuculline inhibits the reaction [Propofol inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]]; Propofol inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein] CTD PMID:11991087 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO 		Propofol inhibits the reaction [Halothane results in increased expression of NOS2 protein]
Propofol inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; Propofol inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein] 		CTD PMID:16965849 PMID:19573522 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]] CTD PMID:24810525 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493 		JBrowse link
G Npy neuropeptide Y multiple interactions EXP Propofol inhibits the reaction [Potassium results in increased secretion of NPY protein] CTD PMID:29320738 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO Propofol inhibits the reaction [MIR186 results in decreased expression of NR3C2 protein] CTD PMID:38146619 NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078 		JBrowse link
G Nufip1 nuclear FMR1 interacting protein 1 multiple interactions
affects response to substance 		EXP
ISO 		NUFIP1 protein affects the reaction [Propofol results in decreased expression of BCL2 protein]; NUFIP1 protein affects the reaction [Propofol results in increased expression of BAX protein]; NUFIP1 protein affects the reaction [Propofol results in increased expression of DLG4 protein]; NUFIP1 protein inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]
[NUFIP1 affects the susceptibility to Propofol] which affects the cleavage of CASP protein; [NUFIP1 affects the susceptibility to Propofol] which affects the expression of BAX protein; [NUFIP1 affects the susceptibility to Propofol] which affects the expression of BCL2 protein 		CTD PMID:38599287 NCBI chr15:57,838,864...57,869,597
Ensembl chr15:57,837,608...57,869,594 		JBrowse link
G Or5ac16 olfactory receptor family 5 subfamily AC member 16 decreases expression ISO Propofol results in decreased expression of OR5AC16 mRNA CTD PMID:21786383
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Propofol results in increased susceptibility to STA 9090] which results in increased cleavage of PARP1 protein CTD PMID:24784839 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions 		ISO Propofol results in decreased expression of PCNA protein
CASC9 protein inhibits the reaction [Propofol results in decreased expression of PCNA protein] 		CTD PMID:35238236 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 decreases expression
multiple interactions 		EXP Propofol results in decreased expression of PEA15 mRNA; Propofol results in decreased expression of PEA15 protein
PEA15 protein inhibits the reaction [Propofol results in decreased expression of BCL2 protein]; PEA15 protein inhibits the reaction [Propofol results in decreased expression of CASP3 protein]; PEA15 protein inhibits the reaction [Propofol results in decreased expression of RPS6KA3 protein]; PEA15 protein inhibits the reaction [Propofol results in decreased phosphorylation of CREB1 protein]; PEA15 protein inhibits the reaction [Propofol results in decreased phosphorylation of MAPK1 protein]; PEA15 protein inhibits the reaction [Propofol results in decreased phosphorylation of MAPK3 protein]; PEA15 protein inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]; PEA15 protein inhibits the reaction [Propofol results in increased expression of BAX protein] 		CTD PMID:31257496 NCBI chr13:87,190,189...87,199,811
Ensembl chr13:87,187,295...87,199,859 		JBrowse link
G Pkd1l3 polycystin 1 like 3, transient receptor potential channel interacting decreases expression ISO Propofol results in decreased expression of PKD1L3 mRNA CTD PMID:35238236 NCBI chr19:54,494,529...54,559,596
Ensembl chr19:54,495,243...54,559,546 		JBrowse link
G Pla2g2c phospholipase A2, group IIC increases expression ISO Propofol results in increased expression of PLA2G2C mRNA CTD PMID:35238236 NCBI chr 5:156,241,142...156,262,368
Ensembl chr 5:156,242,451...156,264,676 		JBrowse link
G Pln phospholamban decreases phosphorylation EXP Propofol results in decreased phosphorylation of PLN protein CTD PMID:27495954 NCBI chr20:33,166,512...33,182,241
Ensembl chr20:33,172,494...33,182,241 		JBrowse link
G Pnn pinin, desmosome associated protein multiple interactions
decreases expression 		ISO Lipopolysaccharides inhibits the reaction [Propofol results in decreased expression of PNN mRNA] CTD PMID:35953652 NCBI chr 6:82,493,032...82,501,345
Ensembl chr 6:82,492,978...82,501,933 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP Propofol inhibits the reaction [Doxorubicin results in increased cleavage of PRKCD protein] CTD PMID:22015447 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839 		JBrowse link
G Prl prolactin increases secretion ISO Propofol results in increased secretion of PRL protein CTD PMID:18482853 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217 		JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions 		ISO Propofol results in increased expression of PTEN protein
CASC9 protein inhibits the reaction [Propofol results in increased expression of PTEN protein] 		CTD PMID:35238236 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein] CTD PMID:19573522 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
G Ren renin multiple interactions ISO [Propofol co-treated with desflurane] results in increased expression of REN protein CTD PMID:8017643 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Rnu12 RNA, U12 small nuclear decreases expression ISO Propofol results in decreased expression of RNU12 mRNA CTD PMID:35238236 NCBI chr 7:116,183,590...116,183,740
Ensembl chr 7:116,183,590...116,183,740 		JBrowse link
G Rorb RAR-related orphan receptor B multiple interactions
decreases expression 		ISO Lipopolysaccharides inhibits the reaction [Propofol results in decreased expression of RORB mRNA] CTD PMID:35953652 NCBI chr 1:225,790,216...225,970,973
Ensembl chr 1:225,790,216...225,970,973 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 decreases expression
multiple interactions 		EXP Propofol results in decreased expression of RPS6KA3 protein
PEA15 protein inhibits the reaction [Propofol results in decreased expression of RPS6KA3 protein] 		CTD PMID:31257496 NCBI chr  X:39,325,926...39,432,017
Ensembl chr  X:39,325,926...39,433,678 		JBrowse link
G Rpsa ribosomal protein SA increases expression
multiple interactions 		ISO Propofol results in increased expression of RPSA mRNA
Lipopolysaccharides promotes the reaction [Propofol results in increased expression of RPSA mRNA] 		CTD PMID:35953652 NCBI chr 8:128,728,761...128,732,736
Ensembl chr 8:128,728,862...128,732,737 		JBrowse link
G Ryr2 ryanodine receptor 2 decreases phosphorylation EXP Propofol results in decreased phosphorylation of RYR2 protein CTD PMID:27495954 NCBI chr17:63,081,527...63,667,141
Ensembl chr17:63,081,527...63,666,705 		JBrowse link
G Serpinf1 serpin family F member 1 increases expression ISO Propofol results in increased expression of SERPINF1 protein CTD PMID:36207479 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,748,506...60,760,898 		JBrowse link
G Set Set nuclear proto-oncogene decreases expression
multiple interactions 		ISO Propofol results in decreased expression of SET mRNA
Lipopolysaccharides inhibits the reaction [Propofol results in decreased expression of SET mRNA] 		CTD PMID:35953652 NCBI chr 3:33,732,319...33,743,433 JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions 		ISO Propofol results in decreased expression of SIRT1 protein
MIR138 promotes the reaction [Propofol results in decreased expression of SIRT1 protein] 		CTD PMID:39441175 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions EXP [Tetradecanoylphorbol Acetate co-treated with Propofol] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of SLC1A1 protein] CTD PMID:17382927 NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:235,963,437...236,045,469 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO Propofol results in decreased expression of SLC2A1 protein CTD PMID:36207479 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742 		JBrowse link
G Slc38a3 solute carrier family 38, member 3 decreases expression ISO Propofol results in decreased expression of SLC38A3 mRNA CTD PMID:35238236 NCBI chr 8:117,202,534...117,220,310
Ensembl chr 8:117,202,536...117,218,630 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression ISO Propofol results in decreased expression of SLC6A3 protein CTD PMID:32612007 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression
multiple interactions 		EXP Propofol results in decreased expression of SLC7A11 protein
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Propofol results in decreased expression of SLC7A11 protein] 		CTD PMID:28663055 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions
decreases expression 		ISO Lipopolysaccharides inhibits the reaction [Propofol results in decreased expression of SMAD2 mRNA] CTD PMID:35953652 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions EXP SNAP25 protein affects the reaction [Propofol affects the localization of STX1A protein] CTD PMID:29320738 NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:144,494,595...144,576,448 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Propofol inhibits the reaction [Doxorubicin results in decreased expression of SOD1 protein] CTD PMID:22015447 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions 		EXP Propofol results in increased expression of SOD2 protein
Propofol inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein] 		CTD PMID:21468576 PMID:22015447 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions 		ISO Propofol results in decreased expression of SQSTM1 protein
MIR138 promotes the reaction [Propofol results in decreased expression of SQSTM1 protein] 		CTD PMID:39441175 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases expression ISO Propofol results in increased expression of SRC mRNA CTD PMID:35953652 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO Propofol results in decreased expression of SRD5A2 mRNA CTD PMID:35238236 NCBI chr 6:27,178,089...27,217,588
Ensembl chr 6:27,178,079...27,217,588 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
decreases phosphorylation 		EXP
ISO 		HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]; Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]; Propofol promotes the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]
Propofol results in increased phosphorylation of STAT3 protein
Propofol decreases phosphorylation of STAT3 protein in colon epithelium 		CTD
RGD		 PMID:24810525 PMID:32386021 RGD:125097524 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stx1a syntaxin 1A multiple interactions
affects localization 		EXP Propofol inhibits the reaction [barium chloride affects the localization of STX1A protein]; SNAP25 protein affects the reaction [Propofol affects the localization of STX1A protein]; STX1A protein modified form inhibits the reaction [Propofol affects the localization of STX1A protein]; STX1A protein modified form inhibits the reaction [Propofol inhibits the reaction [barium chloride affects the localization of STX1A protein]] CTD PMID:29320738 NCBI chr12:27,278,517...27,306,547
Ensembl chr12:27,278,517...27,306,471 		JBrowse link
G Tdh L-threonine dehydrogenase decreases expression ISO Propofol results in decreased expression of TDH mRNA CTD PMID:21786383 NCBI chr15:41,915,766...41,929,307
Ensembl chr15:41,915,766...41,929,307 		JBrowse link
G Th tyrosine hydroxylase decreases expression ISO Propofol results in decreased expression of TH protein CTD PMID:32612007 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression
multiple interactions 		ISO Propofol results in increased expression of TIMP2 mRNA; Propofol results in increased expression of TIMP2 protein
Lipopolysaccharides promotes the reaction [Propofol results in increased expression of TIMP2 mRNA] 		CTD PMID:35953652 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214 		JBrowse link
G Tincr TINCR ubiquitin domain containing increases expression ISO Propofol results in increased expression of TINCR mRNA CTD PMID:35238236 NCBI chr 9:1,476,770...1,477,039
NCBI chr 9:1,474,238...1,476,470
Ensembl chr 9:1,476,147...1,477,238 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] CTD PMID:19433076 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tmc6 transmembrane channel like 6 increases expression ISO Propofol results in increased expression of TMC6 mRNA CTD PMID:35238236 NCBI chr10:103,480,762...103,498,207
Ensembl chr10:103,480,762...103,497,398 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; TLR4 protein affects the reaction [Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] CTD PMID:19433076 PMID:21307008 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression 		EXP
ISO 		Propofol inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]
Propofol results in increased expression of TP53 protein 		CTD PMID:22015447 PMID:28804952 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 decreases expression
multiple interactions 		EXP Propofol results in decreased expression of TRPC6 protein
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole promotes the reaction [Propofol results in decreased expression of TRPC6 protein]; hyperforin inhibits the reaction [Propofol results in decreased expression of TRPC6 protein] 		CTD PMID:36640868 NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:14,043,877...14,149,304 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Propofol CTD PMID:15502008 NCBI chr 9:96,187,382...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 decreases activity
affects metabolic processing
increases glucuronidation
multiple interactions 		ISO Propofol results in decreased activity of UGT1A9 protein
UGT1A9 protein affects the metabolism of Propofol
UGT1A9 protein results in increased glucuronidation of Propofol
[Warfarin binds to and affects the activity of UGT1A9 protein] which affects the glucuronidation of Propofol; licochalcone A inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; shikonin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; Warfarin affects the reaction [UGT1A9 protein results in increased glucuronidation of Propofol] 		CTD PMID:12756209 PMID:14570768 PMID:15286053 PMID:15378558 PMID:15769885 More... NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 increases expression ISO Propofol results in increased expression of UHRF1 mRNA CTD PMID:35238236 NCBI chr 9:1,220,162...1,241,792
Ensembl chr 9:1,222,063...1,241,792 		JBrowse link
G Vim vimentin multiple interactions ISO Propofol affects the reaction [LINC01133 affects the expression of VIM protein] CTD PMID:38146619 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
G Xist X inactive specific transcript increases expression ISO Propofol results in increased expression of XIST mRNA CTD PMID:35238236 NCBI chr  X:72,540,753...72,558,266 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      chemical role 20219
        antioxidant 16310
          radical scavenger 6141
            propofol 170
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic aromatic compound 20199
                                  phenols 19382
                                    propofol 170
paths to the root