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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:propofol
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Accession:CHEBI:44915 term browser browse the term
Definition:A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Synonyms:exact_synonym: 2,6-bis(propan-2-yl)phenol
 related_synonym: 2,6-Diisopropylphenol;   2,6-bis(1-methylethyl)phenol;   Diprivan;   Disoprivan;   Disoprofol;   Formula=C12H18O;   InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3;   InChIKey=OLBCVFGFOZPWHH-UHFFFAOYSA-N;   Rapinovet;   SMILES=CC(C)c1cccc(C(C)C)c1O;   propofolum
 alt_id: CHEBI:44914;   CHEBI:8495
 xref: Beilstein:1866484;   CAS:2078-54-8;   DrugBank:DB00818;   Drug_Central:2302;   KEGG:C07523;   KEGG:D00549;   LINCS:LSM-3847
 xref_mesh: MESH:D015742
 xref: PDBeChem:PFL;   VSDB:1846;   Wikipedia:Propofol


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propofol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin, alpha 1, skeletal muscle multiple interactions EXP HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]]; Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]] CTD PMID:24810525 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP Propofol promotes the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]
Propofol results in increased phosphorylation of AKT1 protein
CTD PMID:24810525 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression
multiple interactions
EXP Propofol results in decreased expression of APAF1 protein
Propofol inhibits the reaction [Doxorubicin results in increased expression of APAF1 protein]
CTD PMID:21468576 PMID:22015447 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein multiple interactions
decreases expression
EXP Bicuculline inhibits the reaction [Propofol results in decreased expression of ARC protein] CTD PMID:18946287 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Avp arginine vasopressin multiple interactions ISO [Propofol co-treated with desflurane] results in increased expression of AVP protein CTD PMID:8017643 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
EXP
ISO
[resveratrol co-treated with Propofol] results in decreased expression of BAX; Propofol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]
Acetylcysteine inhibits the reaction [Propofol results in increased expression of BAX protein]
Propofol results in decreased expression of BAX
CTD PMID:21786383 PMID:22015447 PMID:23353162 PMID:28804952 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
multiple interactions
EXP
ISO
Propofol results in increased expression of BCL2; Propofol results in increased expression of BCL2 mRNA; Propofol results in increased expression of BCL2 protein
Propofol results in decreased expression of BCL2 protein
Acetylcysteine inhibits the reaction [Propofol results in decreased expression of BCL2 protein]
[resveratrol co-treated with Propofol] results in increased expression of BCL2; Propofol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Propofol inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; wortmannin inhibits the reaction [Propofol results in increased expression of BCL2 protein]
CTD PMID:19703415 PMID:21786383 PMID:22015447 PMID:23353162 PMID:24810525 More... NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP Propofol results in decreased expression of BCL2L1 mRNA; Propofol results in decreased expression of BCL2L1 protein CTD PMID:26254736 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of BNIP3 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of BNIP3 protein] CTD PMID:21307008 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G C3 complement C3 multiple interactions ISO [Triglycerides co-treated with Propofol] results in increased expression of C3 protein modified form CTD PMID:15983144 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Propofol CTD PMID:15644869 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Propofol analog results in decreased activity of CA1 protein; Propofol results in decreased activity of CA1 protein CTD PMID:19231207 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Propofol analog results in decreased activity of CA2 protein; Propofol results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression
decreases expression
increases activity
EXP
ISO
[resveratrol co-treated with Propofol] results in decreased expression of CASP3; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; Propofol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]; Propofol inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Propofol inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]
Propofol results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]
Propofol results in increased expression of CASP3 protein modified form
Propofol results in decreased expression of CASP3
Propofol results in increased activity of CASP3 protein
CTD PMID:17640472 PMID:21786383 PMID:22015447 PMID:23353162 PMID:24810525 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 decreases cleavage
multiple interactions
increases cleavage
increases activity
EXP
ISO
Propofol results in decreased cleavage of CASP9 protein
Acetylcysteine inhibits the reaction [Propofol results in increased cleavage of CASP9 protein]
Propofol results in increased activity of CASP9 protein
CTD PMID:21468576 PMID:21786383 PMID:28804952 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases expression
decreases activity
multiple interactions
ISO
EXP
Propofol results in increased expression of CAT protein
Propofol results in decreased activity of CAT protein
Acetylcysteine inhibits the reaction [Propofol results in decreased activity of CAT protein]
CTD PMID:16938161 PMID:21468576 PMID:28804952 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Propofol results in decreased expression of CCNB1 protein CTD PMID:28804952 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Propofol results in increased expression of CCND1 protein CTD PMID:28804952 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions
ISO Propofol results in decreased expression of CDK1 protein
[Propofol results in increased susceptibility to STA 9090] which results in decreased expression of CDK1 protein
CTD PMID:24784839 PMID:28804952 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions
increases expression
EXP Dexmedetomidine inhibits the reaction [Propofol results in increased expression of CDK5R1 protein] CTD PMID:31187143 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions EXP Propofol inhibits the reaction [Acetylcholine results in increased activity of CHRM1 protein]; Propofol inhibits the reaction [Scopolamine Derivatives results in increased activity of CHRM1 protein] CTD PMID:14534362 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA] CTD PMID:21307008 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Propofol results in increased expression of CYCS protein CTD PMID:21786383 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Propofol CTD PMID:15769884 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases phosphorylation
multiple interactions
EXP Propofol results in increased phosphorylation of DPYSL2 protein
Dexmedetomidine inhibits the reaction [Propofol results in increased phosphorylation of DPYSL2 protein]
CTD PMID:31187143 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions
EXP
ISO
Propofol results in decreased expression of EDN1 protein
Propofol inhibits the reaction [EDN1 protein affects the transport of Calcium]
CTD PMID:9138053 PMID:17470888 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [Propofol results in increased susceptibility to STA 9090] which results in decreased expression of EGFR protein CTD PMID:24784839 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Propofol results in increased expression of FAS protein CTD PMID:21786383 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP Lidocaine inhibits the reaction [Propofol results in increased expression of FOS protein]
Propofol results in increased expression of FOS mRNA; Propofol results in increased expression of FOS protein
CTD PMID:10781476 PMID:17136530 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO
EXP
[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Propofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]
CTD PMID:9316872 PMID:10049148 PMID:11399263 PMID:12939268 PMID:22029276 More... NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Propofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3] CTD PMID:29038840 NCBI chr14:37,096,995...37,230,030
Ensembl chr14:37,097,279...37,228,944
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression ISO Propofol results in increased expression of GABRA4 mRNA CTD PMID:16733821 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO Propofol results in increased activity of [GABRA6 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form] CTD PMID:29038840 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form] CTD PMID:10049148 PMID:29038840 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance
multiple interactions
EXP
ISO
GABRB2 protein affects the susceptibility to Propofol
Propofol results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB2 binds to GABRG2 protein alternative form]
Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Propofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]
CTD PMID:11399263 PMID:12939268 PMID:29038840 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO [Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3]; Propofol results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form] CTD PMID:9316872 PMID:22029276 PMID:29038840 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon multiple interactions
decreases response to substance
ISO
EXP
Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]
GABRE protein results in decreased susceptibility to Propofol
CTD PMID:9039914 PMID:10049148 NCBI chr  X:150,060,035...150,078,773
Ensembl chr  X:150,060,040...150,078,693
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO
EXP
[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Propofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]
CTD PMID:9316872 PMID:10049148 PMID:11399263 PMID:12939268 PMID:22029276 More... NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression
multiple interactions
EXP Propofol results in increased expression of GRIA2 protein
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Propofol results in increased expression of GRIA2 protein]
CTD PMID:28663055 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects response to substance ISO GRIN2A protein affects the susceptibility to Propofol CTD PMID:15731593 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Dexmedetomidine inhibits the reaction [Propofol results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Propofol results in decreased phosphorylation of and results in increased activity of GSK3B protein CTD PMID:31187143 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G H3f3c H3 histone family member 3C decreases expression ISO Propofol results in decreased expression of H3C15 mRNA CTD PMID:21786383 NCBI chr 7:86,501,094...86,502,133
Ensembl chr 7:86,501,071...86,502,140
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A protein] CTD PMID:21307008 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP Propofol results in increased expression of HMOX1 protein
HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]; Propofol inhibits the reaction [Streptozocin results in decreased activity of HMOX1 protein]; Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]]
CTD PMID:21468576 PMID:24810525 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il10 interleukin 10 increases expression ISO Propofol results in increased expression of IL10 protein CTD PMID:17032661 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases secretion ISO Propofol results in decreased secretion of IL2RA protein CTD PMID:16119599 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO Propofol results in decreased expression of IL6 protein
Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:17032661 PMID:21307008 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO Propofol decreases phosphorylation of JAK2 protein in colon epithelium RGD PMID:32386021 RGD:125097524 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Propofol results in increased expression of JUN mRNA CTD PMID:10781476 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO [Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form; [Triglycerides co-treated with Propofol] results in increased expression of KNG1 protein modified form; Lidocaine inhibits the reaction [[Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form]; nafamostat inhibits the reaction [[Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form] CTD PMID:10655909 PMID:15983144 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Ldha lactate dehydrogenase A increases activity ISO Propofol increases activity of LDHA protein in colon epithelium RGD PMID:32386021 RGD:125097524 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G LOC102546572 zinc finger protein 709-like decreases expression ISO Propofol results in decreased expression of ZFP617 mRNA CTD PMID:21786383 NCBI chr 7:11,846,077...11,868,732 JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 increases expression ISO Propofol results in increased expression of LRG1 mRNA CTD PMID:21786383 NCBI chr 9:947,516...949,773
Ensembl chr 9:947,516...949,813
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein] CTD PMID:19573522 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K2 protein] CTD PMID:19573522 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein] CTD PMID:19573522 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein] CTD PMID:19573522 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mir1224 microRNA 1224 increases expression EXP Propofol results in increased expression of MIR1224 mRNA CTD PMID:26254736 NCBI chr11:80,306,902...80,306,986
Ensembl chr11:80,306,902...80,306,986
JBrowse link
G Mir146a microRNA 146a decreases expression EXP Propofol results in decreased expression of MIR146A mRNA CTD PMID:26254736 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
JBrowse link
G Mir146b microRNA 146b decreases expression EXP Propofol results in decreased expression of MIR146B mRNA CTD PMID:26254736 NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525
JBrowse link
G Mir155 microRNA 155 decreases expression EXP Propofol results in decreased expression of MIR155 mRNA CTD PMID:26254736 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir221 microRNA 221 decreases expression EXP Propofol results in decreased expression of MIR221 mRNA CTD PMID:26254736 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573
JBrowse link
G Mir222 microRNA 222 decreases expression EXP Propofol results in decreased expression of MIR222 mRNA CTD PMID:26254736 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006
JBrowse link
G Mir27b microRNA 27b increases expression EXP Propofol results in increased expression of MIR27B mRNA CTD PMID:26254736 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529
JBrowse link
G Mir3473 microRNA 3473 increases expression EXP Propofol results in increased expression of MIR3473 mRNA CTD PMID:26254736 NCBI chr13:39,499,246...39,499,312
Ensembl chr13:39,499,246...39,499,312
JBrowse link
G Mir378 microRNA 378 increases expression EXP Propofol results in increased expression of MIR378 mRNA CTD PMID:26254736 NCBI chr18:54,858,559...54,858,623 JBrowse link
G Mir6215 microRNA 6215 increases expression EXP Propofol results in increased expression of MIR6215 mRNA CTD PMID:26254736 NCBI chr 5:151,850,759...151,850,825
Ensembl chr 5:151,850,759...151,850,825
JBrowse link
G Mir665 microRNA 665 increases expression EXP Propofol results in increased expression of MIR665 mRNA CTD PMID:26254736 NCBI chr 6:128,539,440...128,539,533
Ensembl chr 6:128,539,440...128,539,533
JBrowse link
G Mir99a microRNA 99a increases expression EXP Propofol results in increased expression of MIR99A mRNA CTD PMID:26254736 NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Propofol inhibits the reaction [Halothane results in increased phosphorylation of NFKBIA protein] CTD PMID:16965849 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Bicuculline inhibits the reaction [Propofol inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]]; Propofol inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein] CTD PMID:11991087 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
Propofol inhibits the reaction [Halothane results in increased expression of NOS2 protein]
Propofol inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; Propofol inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]
CTD PMID:16965849 PMID:19573522 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]] CTD PMID:24810525 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Npy neuropeptide Y multiple interactions EXP Propofol inhibits the reaction [Potassium results in increased secretion of NPY protein] CTD PMID:29320738 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Olr1539 olfactory receptor 1539 decreases expression ISO Propofol results in decreased expression of OLFR198 mRNA CTD PMID:21786383
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Propofol results in increased susceptibility to STA 9090] which results in increased cleavage of PARP1 protein CTD PMID:24784839 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pln phospholamban decreases phosphorylation EXP Propofol results in decreased phosphorylation of PLN protein CTD PMID:27495954 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP Propofol inhibits the reaction [Doxorubicin results in increased cleavage of PRKCD protein] CTD PMID:22015447 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prl prolactin increases secretion ISO Propofol results in increased secretion of PRL protein CTD PMID:18482853 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein] CTD PMID:19573522 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Ren renin multiple interactions ISO [Propofol co-treated with desflurane] results in increased expression of REN protein CTD PMID:8017643 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Ryr2 ryanodine receptor 2 decreases phosphorylation EXP Propofol results in decreased phosphorylation of RYR2 protein CTD PMID:27495954 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions EXP [Tetradecanoylphorbol Acetate co-treated with Propofol] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of SLC1A1 protein] CTD PMID:17382927 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression ISO Propofol results in decreased expression of SLC6A3 protein CTD PMID:32612007 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression
multiple interactions
EXP Propofol results in decreased expression of SLC7A11 protein
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Propofol results in decreased expression of SLC7A11 protein]
CTD PMID:28663055 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions EXP SNAP25 protein affects the reaction [Propofol affects the localization of STX1A protein] CTD PMID:29320738 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Propofol inhibits the reaction [Doxorubicin results in decreased expression of SOD1 protein] CTD PMID:22015447 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
EXP Propofol results in increased expression of SOD2 protein
Propofol inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]
CTD PMID:21468576 PMID:22015447 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]; Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]; Propofol promotes the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]
Propofol decreases phosphorylation of STAT3 protein in colon epithelium
Propofol results in increased phosphorylation of STAT3 protein
CTD PMID:24810525 PMID:32386021 RGD:125097524 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stx1a syntaxin 1A multiple interactions
affects localization
EXP Propofol inhibits the reaction [barium chloride affects the localization of STX1A protein]; SNAP25 protein affects the reaction [Propofol affects the localization of STX1A protein]; STX1A protein modified form inhibits the reaction [Propofol affects the localization of STX1A protein]; STX1A protein modified form inhibits the reaction [Propofol inhibits the reaction [barium chloride affects the localization of STX1A protein]] CTD PMID:29320738 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
JBrowse link
G Tdh L-threonine dehydrogenase decreases expression ISO Propofol results in decreased expression of TDH mRNA CTD PMID:21786383 NCBI chr15:37,739,823...37,753,365
Ensembl chr15:37,739,823...37,753,365
JBrowse link
G Th tyrosine hydroxylase decreases expression ISO Propofol results in decreased expression of TH protein CTD PMID:32612007 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] CTD PMID:19433076 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; TLR4 protein affects the reaction [Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] CTD PMID:19433076 PMID:21307008 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
EXP
ISO
Propofol inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]
Propofol results in increased expression of TP53 protein
CTD PMID:22015447 PMID:28804952 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Propofol CTD PMID:15502008 NCBI chr 9:88,739,577...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 decreases activity
multiple interactions
increases glucuronidation
affects metabolic processing
ISO Propofol results in decreased activity of UGT1A9 protein
[Warfarin binds to and affects the activity of UGT1A9 protein] which affects the glucuronidation of Propofol; licochalcone A inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; shikonin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; Warfarin affects the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]
UGT1A9 protein affects the metabolism of Propofol
CTD PMID:12756209 PMID:14570768 PMID:15286053 PMID:15378558 PMID:15769885 More... NCBI chr 9:88,696,981...88,808,465 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      chemical role 19345
        antioxidant 14443
          radical scavenger 6231
            propofol 97
              4-hydroxypropofol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic aromatic compound 19184
                                  phenols 18147
                                    propofol 97
                                      4-hydroxypropofol 0
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