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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:propofol
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Accession:CHEBI:44915 term browser browse the term
Definition:A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Synonyms:exact_synonym: 2,6-bis(propan-2-yl)phenol
 related_synonym: 2,6-Diisopropylphenol;   2,6-bis(1-methylethyl)phenol;   Diprivan;   Disoprivan;   Disoprofol;   Formula=C12H18O;   InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3;   InChIKey=OLBCVFGFOZPWHH-UHFFFAOYSA-N;   Rapinovet;   SMILES=CC(C)c1cccc(C(C)C)c1O;   propofolum
 alt_id: CHEBI:44914;   CHEBI:8495
 xref: Beilstein:1866484;   CAS:2078-54-8;   DrugBank:DB00818;   Drug_Central:2302;   KEGG:C07523;   KEGG:D00549;   LINCS:LSM-3847
 xref_mesh: MESH:D015742
 xref: PDBeChem:PFL;   VSDB:1846;   Wikipedia:Propofol


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propofol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin, alpha 1, skeletal muscle multiple interactions EXP HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]]; Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]] CTD PMID:24810525 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP Propofol promotes the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]
Propofol results in increased phosphorylation of AKT1 protein
CTD PMID:24810525 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression
multiple interactions
EXP Propofol results in decreased expression of APAF1 protein
Propofol inhibits the reaction [Doxorubicin results in increased expression of APAF1 protein]
CTD PMID:21468576 PMID:22015447 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein multiple interactions
decreases expression
EXP Bicuculline inhibits the reaction [Propofol results in decreased expression of ARC protein] CTD PMID:18946287 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Avp arginine vasopressin multiple interactions ISO [Propofol co-treated with desflurane] results in increased expression of AVP protein CTD PMID:8017643 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
EXP
ISO
[resveratrol co-treated with Propofol] results in decreased expression of BAX; Propofol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]
Acetylcysteine inhibits the reaction [Propofol results in increased expression of BAX protein]
Propofol results in decreased expression of BAX
CTD PMID:21786383 PMID:22015447 PMID:23353162 PMID:28804952 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
multiple interactions
EXP
ISO
Propofol results in increased expression of BCL2; Propofol results in increased expression of BCL2 mRNA; Propofol results in increased expression of BCL2 protein
Propofol results in decreased expression of BCL2 protein
Acetylcysteine inhibits the reaction [Propofol results in decreased expression of BCL2 protein]
[resveratrol co-treated with Propofol] results in increased expression of BCL2; Propofol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Propofol inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; wortmannin inhibits the reaction [Propofol results in increased expression of BCL2 protein]
CTD PMID:19703415 PMID:21786383 PMID:22015447 PMID:23353162 PMID:24810525 PMID:28804952 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP Propofol results in decreased expression of BCL2L1 mRNA; Propofol results in decreased expression of BCL2L1 protein CTD PMID:26254736 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of BNIP3 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of BNIP3 protein] CTD PMID:21307008 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G C3 complement C3 multiple interactions ISO [Triglycerides co-treated with Propofol] results in increased expression of C3 protein modified form CTD PMID:15983144 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Propofol CTD PMID:15644869 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Propofol analog results in decreased activity of CA1 protein; Propofol results in decreased activity of CA1 protein CTD PMID:19231207 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Propofol analog results in decreased activity of CA2 protein; Propofol results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression
decreases expression
increases activity
EXP
ISO
[resveratrol co-treated with Propofol] results in decreased expression of CASP3; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; Propofol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]; Propofol inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Propofol inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]
Propofol results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]
Propofol results in increased expression of CASP3 protein modified form
Propofol results in decreased expression of CASP3
Propofol results in increased activity of CASP3 protein
CTD PMID:17640472 PMID:21786383 PMID:22015447 PMID:23353162 PMID:24810525 PMID:26254736 PMID:28804952 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 decreases cleavage
multiple interactions
increases cleavage
increases activity
EXP
ISO
Propofol results in decreased cleavage of CASP9 protein
Acetylcysteine inhibits the reaction [Propofol results in increased cleavage of CASP9 protein]
Propofol results in increased activity of CASP9 protein
CTD PMID:21468576 PMID:21786383 PMID:28804952 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases expression
decreases activity
multiple interactions
ISO
EXP
Propofol results in increased expression of CAT protein
Propofol results in decreased activity of CAT protein
Acetylcysteine inhibits the reaction [Propofol results in decreased activity of CAT protein]
CTD PMID:16938161 PMID:21468576 PMID:28804952 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Propofol results in decreased expression of CCNB1 protein CTD PMID:28804952 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Propofol results in increased expression of CCND1 protein CTD PMID:28804952 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions
ISO Propofol results in decreased expression of CDK1 protein
[Propofol results in increased susceptibility to STA 9090] which results in decreased expression of CDK1 protein
CTD PMID:24784839 PMID:28804952 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions
increases expression
EXP Dexmedetomidine inhibits the reaction [Propofol results in increased expression of CDK5R1 protein] CTD PMID:31187143 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions EXP Propofol inhibits the reaction [Acetylcholine results in increased activity of CHRM1 protein]; Propofol inhibits the reaction [Scopolamine Derivatives results in increased activity of CHRM1 protein] CTD PMID:14534362 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA] CTD PMID:21307008 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Propofol results in increased expression of CYCS protein CTD PMID:21786383 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Propofol CTD PMID:15769884 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases phosphorylation
multiple interactions
EXP Propofol results in increased phosphorylation of DPYSL2 protein
Dexmedetomidine inhibits the reaction [Propofol results in increased phosphorylation of DPYSL2 protein]
CTD PMID:31187143 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions
EXP
ISO
Propofol results in decreased expression of EDN1 protein
Propofol inhibits the reaction [EDN1 protein affects the transport of Calcium]
CTD PMID:9138053 PMID:17470888 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [Propofol results in increased susceptibility to STA 9090] which results in decreased expression of EGFR protein CTD PMID:24784839 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Propofol results in increased expression of FAS protein CTD PMID:21786383 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP Lidocaine inhibits the reaction [Propofol results in increased expression of FOS protein]
Propofol results in increased expression of FOS mRNA; Propofol results in increased expression of FOS protein
CTD PMID:10781476 PMID:17136530 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO
EXP
[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Propofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]
CTD PMID:9316872 PMID:10049148 PMID:11399263 PMID:12939268 PMID:22029276 PMID:29038840 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Propofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3] CTD PMID:29038840 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression ISO Propofol results in increased expression of GABRA4 mRNA CTD PMID:16733821 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO Propofol results in increased activity of [GABRA6 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form] CTD PMID:29038840 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form] CTD PMID:10049148 PMID:29038840 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance
multiple interactions
EXP
ISO
GABRB2 protein affects the susceptibility to Propofol
Propofol results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB2 binds to GABRG2 protein alternative form]
Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Propofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]
CTD PMID:11399263 PMID:12939268 PMID:29038840 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO [Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3]; Propofol results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form] CTD PMID:9316872 PMID:22029276 PMID:29038840 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon multiple interactions
decreases response to substance
ISO
EXP
Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]
GABRE protein results in decreased susceptibility to Propofol
CTD PMID:9039914 PMID:10049148 NCBI chr  X:152,220,180...152,237,347
Ensembl chr  X:152,218,707...152,237,361
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO
EXP
[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Propofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]
CTD PMID:9316872 PMID:10049148 PMID:11399263 PMID:12939268 PMID:22029276 PMID:29038840 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression
multiple interactions
EXP Propofol results in increased expression of GRIA2 protein
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Propofol results in increased expression of GRIA2 protein]
CTD PMID:28663055 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects response to substance ISO GRIN2A protein affects the susceptibility to Propofol CTD PMID:15731593 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Dexmedetomidine inhibits the reaction [Propofol results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Propofol results in decreased phosphorylation of and results in increased activity of GSK3B protein CTD PMID:31187143 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G H3f3c H3 histone family member 3C decreases expression ISO Propofol results in decreased expression of H3C15 mRNA CTD PMID:21786383 NCBI chr 7:94,777,659...94,778,656
Ensembl chr 7:94,777,702...94,778,696
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A protein] CTD PMID:21307008 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP Propofol results in increased expression of HMOX1 protein
HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]; Propofol inhibits the reaction [Streptozocin results in decreased activity of HMOX1 protein]; Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]]
CTD PMID:21468576 PMID:24810525 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il10 interleukin 10 increases expression ISO Propofol results in increased expression of IL10 protein CTD PMID:17032661 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases secretion ISO Propofol results in decreased secretion of IL2RA protein CTD PMID:16119599 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO Propofol results in decreased expression of IL6 protein
Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:17032661 PMID:21307008 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Propofol results in increased expression of JUN mRNA CTD PMID:10781476 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO [Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form; [Triglycerides co-treated with Propofol] results in increased expression of KNG1 protein modified form; Lidocaine inhibits the reaction [[Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form]; nafamostat inhibits the reaction [[Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form] CTD PMID:10655909 PMID:15983144 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lce1c late cornified envelope 1C increases expression ISO Propofol results in increased expression of LCE1C mRNA CTD PMID:21786383
G LOC102546572 zinc finger protein 709-like decreases expression ISO Propofol results in decreased expression of ZFP617 mRNA CTD PMID:21786383 NCBI chr 7:15,015,985...15,038,622 JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 increases expression ISO Propofol results in increased expression of LRG1 mRNA CTD PMID:21786383 NCBI chr 9:10,952,424...10,954,664
Ensembl chr 9:10,952,374...10,954,681
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein] CTD PMID:19573522 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K2 protein] CTD PMID:19573522 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein] CTD PMID:19573522 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein] CTD PMID:19573522 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mir1224 microRNA 1224 increases expression EXP Propofol results in increased expression of MIR1224 mRNA CTD PMID:26254736 NCBI chr11:83,992,628...83,992,712
Ensembl chr11:83,992,628...83,992,712
JBrowse link
G Mir146a microRNA 146a decreases expression EXP Propofol results in decreased expression of MIR146A mRNA CTD PMID:26254736 NCBI chr10:28,962,476...28,962,570
Ensembl chr10:28,962,476...28,962,570
JBrowse link
G Mir146b microRNA 146b decreases expression EXP Propofol results in decreased expression of MIR146B mRNA CTD PMID:26254736 NCBI chr 1:266,089,488...266,089,575
Ensembl chr 1:266,089,488...266,089,575
JBrowse link
G Mir155 microRNA 155 decreases expression EXP Propofol results in decreased expression of MIR155 mRNA CTD PMID:26254736 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Mir221 microRNA 221 decreases expression EXP Propofol results in decreased expression of MIR221 mRNA CTD PMID:26254736 NCBI chr  X:3,684,480...3,684,588
Ensembl chr  X:3,684,480...3,684,588
JBrowse link
G Mir222 microRNA 222 decreases expression EXP Propofol results in decreased expression of MIR222 mRNA CTD PMID:26254736 NCBI chr  X:3,683,919...3,684,021
Ensembl chr  X:3,683,919...3,684,021
JBrowse link
G Mir27b microRNA 27b increases expression EXP Propofol results in increased expression of MIR27B mRNA CTD PMID:26254736 NCBI chr17:823,461...823,557
Ensembl chr17:823,461...823,557
JBrowse link
G Mir3473 microRNA 3473 increases expression EXP Propofol results in increased expression of MIR3473 mRNA CTD PMID:26254736 NCBI chr13:44,719,335...44,719,401
Ensembl chr13:44,719,335...44,719,401
JBrowse link
G Mir378 microRNA 378 increases expression EXP Propofol results in increased expression of MIR378 mRNA CTD PMID:26254736 NCBI chr18:56,726,150...56,726,214 JBrowse link
G Mir6215 microRNA 6215 increases expression EXP Propofol results in increased expression of MIR6215 mRNA CTD PMID:26254736 NCBI chr 5:158,060,994...158,061,060
Ensembl chr 5:158,060,994...158,061,060
JBrowse link
G Mir665 microRNA 665 increases expression EXP Propofol results in increased expression of MIR665 mRNA CTD PMID:26254736 NCBI chr 6:133,706,457...133,706,550
Ensembl chr 6:133,706,457...133,706,550
JBrowse link
G Mir99a microRNA 99a increases expression EXP Propofol results in increased expression of MIR99A mRNA CTD PMID:26254736 NCBI chr11:16,052,153...16,052,233
Ensembl chr11:16,052,153...16,052,233
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Propofol inhibits the reaction [Halothane results in increased phosphorylation of NFKBIA protein] CTD PMID:16965849 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Bicuculline inhibits the reaction [Propofol inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]]; Propofol inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein] CTD PMID:11991087 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
Propofol inhibits the reaction [Halothane results in increased expression of NOS2 protein]
Propofol inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; Propofol inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]
CTD PMID:16965849 PMID:19573522 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]] CTD PMID:24810525 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Npy neuropeptide Y multiple interactions EXP Propofol inhibits the reaction [Potassium results in increased secretion of NPY protein] CTD PMID:29320738 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Olr1539 olfactory receptor 1539 decreases expression ISO Propofol results in decreased expression of OLFR198 mRNA CTD PMID:21786383 Ensembl chr11:43,309,759...43,310,679 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Propofol results in increased susceptibility to STA 9090] which results in increased cleavage of PARP1 protein CTD PMID:24784839 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pln phospholamban decreases phosphorylation EXP Propofol results in decreased phosphorylation of PLN protein CTD PMID:27495954 NCBI chr20:34,633,157...34,642,904
Ensembl chr20:34,633,157...34,642,904
JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP Propofol inhibits the reaction [Doxorubicin results in increased cleavage of PRKCD protein] CTD PMID:22015447 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prl prolactin increases secretion ISO Propofol results in increased secretion of PRL protein CTD PMID:18482853 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein] CTD PMID:19573522 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Ren renin multiple interactions ISO [Propofol co-treated with desflurane] results in increased expression of REN protein CTD PMID:8017643 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Ryr2 ryanodine receptor 2 decreases phosphorylation EXP Propofol results in decreased phosphorylation of RYR2 protein CTD PMID:27495954 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions EXP [Tetradecanoylphorbol Acetate co-treated with Propofol] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of SLC1A1 protein] CTD PMID:17382927 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression ISO Propofol results in decreased expression of SLC6A3 protein CTD PMID:32612007 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression
multiple interactions
EXP Propofol results in decreased expression of SLC7A11 protein
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Propofol results in decreased expression of SLC7A11 protein]
CTD PMID:28663055 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions EXP SNAP25 protein affects the reaction [Propofol affects the localization of STX1A protein] CTD PMID:29320738 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Propofol inhibits the reaction [Doxorubicin results in decreased expression of SOD1 protein] CTD PMID:22015447 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
EXP Propofol results in increased expression of SOD2 protein
Propofol inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]
CTD PMID:21468576 PMID:22015447 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
EXP HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]; Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]; Propofol promotes the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]
Propofol results in increased phosphorylation of STAT3 protein
CTD PMID:24810525 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stx1a syntaxin 1A multiple interactions
affects localization
EXP Propofol inhibits the reaction [barium chloride affects the localization of STX1A protein]; SNAP25 protein affects the reaction [Propofol affects the localization of STX1A protein]; STX1A protein modified form inhibits the reaction [Propofol affects the localization of STX1A protein]; STX1A protein modified form inhibits the reaction [Propofol inhibits the reaction [barium chloride affects the localization of STX1A protein]] CTD PMID:29320738 NCBI chr12:24,682,050...24,710,002
Ensembl chr12:24,682,041...24,710,019
JBrowse link
G Tdh L-threonine dehydrogenase decreases expression ISO Propofol results in decreased expression of TDH mRNA CTD PMID:21786383 NCBI chr15:46,667,926...46,682,752
Ensembl chr15:46,667,926...46,681,467
JBrowse link
G Th tyrosine hydroxylase decreases expression ISO Propofol results in decreased expression of TH protein CTD PMID:32612007 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] CTD PMID:19433076 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; TLR4 protein affects the reaction [Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] CTD PMID:19433076 PMID:21307008 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
EXP
ISO
Propofol inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]
Propofol results in increased expression of TP53 protein
CTD PMID:22015447 PMID:28804952 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Propofol CTD PMID:15502008 NCBI chr 9:95,233,957...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 decreases activity
multiple interactions
ISO Propofol results in decreased activity of UGT1A8 protein
Propofol promotes the reaction [UGT1A8 protein results in increased glucuronidation of Hymecromone]
CTD PMID:15378558 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 decreases activity
multiple interactions
increases glucuronidation
affects metabolic processing
ISO Propofol results in decreased activity of UGT1A9 protein
[Warfarin binds to and affects the activity of UGT1A9 protein] which affects the glucuronidation of Propofol; licochalcone A inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; shikonin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; Warfarin affects the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]
UGT1A9 protein affects the metabolism of Propofol
CTD PMID:12756209 PMID:14570768 PMID:15286053 PMID:15378558 PMID:15769885 PMID:15988124 PMID:18816295 PMID:25393417 PMID:26875642 PMID:31128210 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      chemical role 19283
        antioxidant 14226
          radical scavenger 5207
            propofol 97
              4-hydroxypropofol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic aromatic compound 19146
                                  phenols 18144
                                    propofol 97
                                      4-hydroxypropofol 0
paths to the root