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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pentan-1-ol
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Accession:CHEBI:44884 term browser browse the term
Definition:An alkyl alcohol that is pentane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It has been isolated from Melicope ptelefolia.
Synonyms:related_synonym: 1-pentol;   1-pentyl alcohol;   Amyl alcohol normal;   Amylalkohol;   Formula=C5H12O;   InChI=1S/C5H12O/c1-2-3-4-5-6/h6H,2-5H2,1H3;   InChIKey=AMQJEAYHLZJPGS-UHFFFAOYSA-N;   Pentylalkohol;   SMILES=CCCCCO;   alcool amylique;   amylol;   butylcarbinol;   n-Amylalkohol;   n-C5H11OH;   n-amyl alcohol;   n-butylcarbinol;   n-pentan-1-ol;   n-pentyl alcohol;   pentanol-1;   pentyl alcohol;   primary amyl alcohol
 xref: Beilstein:1730975;   CAS:71-41-0;   Gmelin:25922;   HMDB:HMDB0013036;   KEGG:C16834
 xref_mesh: MESH:C024999
 xref: MetaCyc:PENTANOL;   PDBeChem:PE9;   PMID:16348804;   PMID:21485271;   PMID:8033286;   Reaxys:1730975;   Wikipedia:1-Pentanol


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pentan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions ISO n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]] CTD PMID:11821649 NCBI chr15:42,808,897...42,825,179
Ensembl chr15:42,808,897...42,825,179
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]] CTD PMID:11821649 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
dipentyl phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions EXP [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of ACAA2 mRNA CTD PMID:25055962 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP di-n-pentyl phthalate results in increased expression of AKR1B8 mRNA CTD PMID:19560483 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
ISO di-n-pentyl phthalate binds to AR protein
di-n-pentyl phthalate inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; di-n-pentyl phthalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
CTD PMID:14751673, PMID:15840436, PMID:28571686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP di-n-pentyl phthalate results in increased expression of ATP1A1 mRNA CTD PMID:19560483 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression EXP di-n-pentyl phthalate results in decreased expression of BMP6 mRNA CTD PMID:19560483 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
increases expression
decreases expression
EXP [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11A1 mRNA
di-n-pentyl phthalate results in increased expression of CYP11A1 mRNA
di-n-pentyl phthalate results in decreased expression of CYP11A1 mRNA
CTD PMID:21177253, PMID:21633115, PMID:22112501, PMID:25055962, PMID:26472102 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression
multiple interactions
EXP di-n-pentyl phthalate results in decreased expression of CYP11B1 mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11B1 mRNA
CTD PMID:22112501, PMID:25055962 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression
multiple interactions
EXP di-n-pentyl phthalate results in decreased expression of CYP11B2 mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11B2 mRNA
CTD PMID:22112501, PMID:25055962 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity
decreases expression
multiple interactions
EXP di-n-pentyl phthalate results in decreased activity of CYP17A1 protein
di-n-pentyl phthalate results in decreased expression of CYP17A1 mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP17A1 mRNA
CTD PMID:6829050, PMID:22112501, PMID:25055962, PMID:26472102 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP di-n-pentyl phthalate results in increased expression of CYP19A1 mRNA CTD PMID:19560483 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression EXP di-n-pentyl phthalate results in increased expression of CYP27A1 mRNA CTD PMID:26472102 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression EXP di-n-pentyl phthalate results in decreased expression of CYP51 mRNA CTD PMID:26472102 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase multiple interactions
decreases expression
EXP [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of DHCR7 mRNA
di-n-pentyl phthalate results in decreased expression of DHCR7 mRNA
CTD PMID:22112501, PMID:25055962 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Ebp EBP, cholestenol delta-isomerase decreases expression EXP di-n-pentyl phthalate results in decreased expression of EBP mRNA CTD PMID:26472102 NCBI chr  X:15,049,394...15,055,782
Ensembl chr  X:15,049,462...15,055,781
JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
ISO di-n-pentyl phthalate analog binds to ESR1 protein; di-n-pentyl phthalate binds to ESR1 protein
di-n-pentyl phthalate binds to and results in increased activity of ESR1 protein; di-n-pentyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [di-n-pentyl phthalate binds to and results in increased activity of ESR1 protein]
CTD PMID:15464722, PMID:15840436, PMID:20822795, PMID:28571686 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
ISO di-n-pentyl phthalate binds to and results in decreased activity of ESR2 protein; di-n-pentyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]
di-n-pentyl phthalate analog binds to ESR2 protein
CTD PMID:15464722, PMID:15840436, PMID:28571686 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression EXP di-n-pentyl phthalate results in decreased expression of FGFR2 mRNA CTD PMID:26472102 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fsd2 fibronectin type III and SPRY domain containing 2 decreases expression EXP di-n-pentyl phthalate results in decreased expression of FSD2 mRNA CTD PMID:26472102 NCBI chr 1:143,364,867...143,398,123
Ensembl chr 1:143,364,867...143,398,093
JBrowse link
G Gata4 GATA binding protein 4 increases expression EXP di-n-pentyl phthalate results in increased expression of GATA4 mRNA CTD PMID:22112501 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Grb14 growth factor receptor bound protein 14 increases expression EXP di-n-pentyl phthalate results in increased expression of GRB14 mRNA CTD PMID:15728792 NCBI chr 3:50,937,403...51,054,447
Ensembl chr 3:50,937,669...51,054,378
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 decreases expression EXP di-n-pentyl phthalate results in decreased expression of HEY1 mRNA CTD PMID:26472102 NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
JBrowse link
G Hnf1a HNF1 homeobox A decreases expression EXP di-n-pentyl phthalate results in decreased expression of HNF1A mRNA CTD PMID:15728792 NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342
JBrowse link
G Hoxa1 homeobox A1 multiple interactions ISO di-n-pentyl phthalate inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA] CTD PMID:23696197 NCBI chr 4:82,124,358...82,127,182
Ensembl chr 4:82,125,406...82,127,066
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression EXP di-n-pentyl phthalate results in decreased expression of HSD11B2 mRNA CTD PMID:19560483 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 increases expression EXP di-n-pentyl phthalate results in increased expression of HSD17B11 mRNA CTD PMID:26472102 NCBI chr14:7,054,724...7,104,567
Ensembl chr14:7,073,445...7,104,566
JBrowse link
G Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 increases expression EXP di-n-pentyl phthalate results in increased expression of HSD17B8 mRNA CTD PMID:19560483, PMID:26472102 NCBI chr20:3,817,212...3,819,316
Ensembl chr20:3,817,179...3,819,235
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression EXP di-n-pentyl phthalate results in decreased expression of ID1 mRNA CTD PMID:26472102 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP di-n-pentyl phthalate results in decreased expression of IGF1 mRNA CTD PMID:26472102 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 decreases expression EXP di-n-pentyl phthalate results in decreased expression of IGFBP7 mRNA CTD PMID:19560483 NCBI chr14:33,010,300...33,070,193
Ensembl chr14:33,010,300...33,070,190
JBrowse link
G Inha inhibin subunit alpha multiple interactions
decreases expression
EXP [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of INHA mRNA
di-n-pentyl phthalate results in decreased expression of INHA mRNA
CTD PMID:25055962, PMID:26472102 NCBI chr 9:82,700,482...82,703,383
Ensembl chr 9:82,700,468...82,703,400
JBrowse link
G Insig1 insulin induced gene 1 decreases expression EXP di-n-pentyl phthalate results in decreased expression of INSIG1 mRNA CTD PMID:15728792 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Insl3 insulin-like 3 multiple interactions
decreases expression
EXP [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of INSL3 mRNA
di-n-pentyl phthalate results in decreased expression of INSL3 mRNA
CTD PMID:21177253, PMID:21633115, PMID:22112501, PMID:25055962, PMID:26454885 NCBI chr16:20,120,753...20,122,702
Ensembl chr16:20,121,352...20,122,696
JBrowse link
G Ldlr low density lipoprotein receptor decreases expression EXP di-n-pentyl phthalate results in decreased expression of LDLR mRNA CTD PMID:15728792 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP di-n-pentyl phthalate results in decreased expression of LHCGR mRNA CTD PMID:15728792 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
JBrowse link
G Msh2 mutS homolog 2 decreases expression
increases expression
EXP di-n-pentyl phthalate results in decreased expression of MSH2 mRNA
di-n-pentyl phthalate results in increased expression of MSH2 mRNA
CTD PMID:26472102 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Myocd myocardin decreases expression EXP di-n-pentyl phthalate results in decreased expression of MYOCD mRNA CTD PMID:26472102 NCBI chr10:51,682,053...51,781,458
Ensembl chr10:51,683,540...51,778,986
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 decreases expression
multiple interactions
EXP di-n-pentyl phthalate results in decreased expression of NR0B1 mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of NR0B1 mRNA
CTD PMID:15728792, PMID:22112501, PMID:25055962 NCBI chr  X:54,734,385...54,738,513
Ensembl chr  X:54,734,385...54,738,513
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects binding
increases activity
ISO di-n-pentyl phthalate analog binds to NR1I3 protein; di-n-pentyl phthalate binds to NR1I3 protein
di-n-pentyl phthalate results in increased activity of NR1I3 protein
CTD PMID:25938866, PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression EXP di-n-pentyl phthalate results in increased expression of NR4A1 mRNA CTD PMID:15728792 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression EXP di-n-pentyl phthalate results in decreased expression of NR4A3 mRNA CTD PMID:19560483 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like decreases expression EXP di-n-pentyl phthalate results in decreased expression of NSDHL mRNA CTD PMID:19560483 NCBI chr  X:152,933,118...152,964,399
Ensembl chr  X:152,933,069...152,964,390
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects binding ISO di-n-pentyl phthalate binds to PPARA protein CTD PMID:23843199 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding ISO di-n-pentyl phthalate binds to PPARB protein CTD PMID:23843199 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding ISO di-n-pentyl phthalate binds to PPARG protein CTD PMID:23843199 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Rhox10 reproductive homeobox 10 decreases expression EXP di-n-pentyl phthalate results in decreased expression of RHOX10 mRNA CTD PMID:22112501 NCBI chr  X:124,207,017...124,211,455
Ensembl chr  X:124,207,017...124,211,455
JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO di-n-pentyl phthalate binds to RXRA protein CTD PMID:23843199 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Rxrb retinoid X receptor beta affects binding ISO di-n-pentyl phthalate binds to RXRB protein CTD PMID:23843199 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
JBrowse link
G Rxrg retinoid X receptor gamma affects binding ISO di-n-pentyl phthalate binds to RXRG protein CTD PMID:23843199 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
decreases expression
EXP [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of SCARB1 mRNA
di-n-pentyl phthalate results in decreased expression of SCARB1 mRNA
CTD PMID:19560483, PMID:22112501, PMID:25055962, PMID:26472102 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Snx17 sorting nexin 17 multiple interactions EXP [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of SNX17 mRNA CTD PMID:25055962 NCBI chr 6:26,541,137...26,546,650
Ensembl chr 6:26,541,138...26,546,545
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression EXP di-n-pentyl phthalate results in decreased expression of SOX9 mRNA CTD PMID:26472102 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression EXP di-n-pentyl phthalate results in decreased expression of SRD5A1 mRNA CTD PMID:19560483 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
increases expression
decreases expression
EXP [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of STAR mRNA
di-n-pentyl phthalate results in increased expression of STAR mRNA
di-n-pentyl phthalate results in decreased expression of STAR mRNA
CTD PMID:19560483, PMID:21177253, PMID:21633115, PMID:22112501, PMID:25055962, PMID:26472102 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tcf21 transcription factor 21 decreases expression EXP di-n-pentyl phthalate results in decreased expression of TCF21 mRNA CTD PMID:26472102 NCBI chr 1:23,906,717...23,909,576
Ensembl chr 1:23,906,717...23,909,566
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        refrigerant 17418
          pentane 212
            pentanol 56
              pentan-1-ol 56
                dipentyl phthalate 54
                monopentyl phthalate 0
                pentyl acetate 0
                pentyl butyrate 0
                pentyl propanoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  alkane 13683
                                    pentane 212
                                      pentanol 56
                                        pentan-1-ol 56
                                          dipentyl phthalate 54
                                          monopentyl phthalate 0
                                          pentyl acetate 0
                                          pentyl butyrate 0
                                          pentyl propanoate 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.