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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diallyl disulfide
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Accession:CHEBI:4488 term browser browse the term
Definition:An organic disulfide where the organic group specified is allyl. It has been isolated from garlic and other species of the genus Allium.
Synonyms:exact_synonym: 3-(prop-2-en-1-yldisulfanyl)prop-1-ene
 related_synonym: 2-propenyl disulphide;   3,3'-disulfanediylbis(prop-1-ene);   3,3'-dithiobis(prop-1-ene);   3-(allyldisulfanyl)-1-propene;   4,5-dithia-1,7-octadiene;   Formula=C6H10S2;   InChI=1S/C6H10S2/c1-3-5-7-8-6-4-2/h3-4H,1-2,5-6H2;   InChIKey=PFRGXCVKLLPLIP-UHFFFAOYSA-N;   SMILES=C=CCSSCC=C;   allyl disulfide;   diallyl disulphide
 xref: Beilstein:1699241;   CAS:2179-57-9;   Gmelin:217847;   HMDB:HMDB0033966;   KEGG:C08369;   KNApSAcK:C00001243
 xref_mesh: MESH:C028009
 xref: PMID:11375895;   PMID:16462049;   PMID:17534841;   Reaxys:1699241;   Wikipedia:Diallyl_disulfide



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diallyl disulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO diallyl disulfide results in increased expression of ABCB1 mRNA CTD PMID:22397993 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases expression
increases expression
ISO diallyl disulfide results in decreased expression of ABCC1 mRNA
diallyl disulfide results in increased expression of ABCC1 mRNA
CTD PMID:22397993 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
affects expression
ISO diallyl disulfide results in increased expression of ABCC3 mRNA
diallyl disulfide affects the expression of ABCC3 mRNA
CTD PMID:22397993 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression
decreases expression
ISO diallyl disulfide results in increased expression of ABCC4 mRNA
diallyl disulfide results in decreased expression of ABCC4 mRNA
CTD PMID:22397993 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 decreases expression
increases expression
ISO diallyl disulfide results in decreased expression of ABCC6 mRNA
diallyl disulfide results in increased expression of ABCC6 mRNA
CTD PMID:22397993 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO diallyl disulfide results in increased phosphorylation of AKT1 protein CTD PMID:23663050 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO diallyl disulfide results in increased expression of ATF3 protein CTD PMID:15897233 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO diallyl disulfide results in increased expression of BAX mRNA; diallyl disulfide results in increased expression of BAX protein CTD PMID:17647244 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP
ISO
diallyl disulfide results in decreased expression of BCL2 protein
diallyl disulfide results in decreased expression of BCL2 mRNA; diallyl disulfide results in decreased expression of BCL2 protein
CTD PMID:14522920 PMID:16052692 PMID:17647244 PMID:30677442 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression ISO diallyl disulfide results in decreased expression of BDNF protein CTD PMID:23732363 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO diallyl disulfide results in decreased expression of BIRC3 protein CTD PMID:17647244 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO diallyl disulfide results in decreased expression of BIRC5 protein CTD PMID:17647244 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
ISO diallyl disulfide results in increased activity of CASP3 protein
diallyl disulfide results in increased cleavage of CASP3 protein
diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]
CTD PMID:14522920 PMID:17647244 PMID:30677442 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 increases activity ISO diallyl disulfide results in increased activity of CASP4 protein CTD PMID:17647244 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
ISO diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]
diallyl disulfide results in increased cleavage of CASP8 protein
CTD PMID:30677442 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage
multiple interactions
ISO diallyl disulfide results in increased activity of CASP9 protein
diallyl disulfide results in increased cleavage of CASP9 protein
diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP9 protein]
CTD PMID:14522920 PMID:17647244 PMID:30677442 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cast calpastatin decreases expression ISO diallyl disulfide results in decreased expression of CAST mRNA; diallyl disulfide results in decreased expression of CAST protein CTD PMID:17647244 NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659
JBrowse link
G Cat catalase multiple interactions EXP diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:24293383 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO diallyl disulfide promotes the reaction [NOS3 protein binds to CAV1 protein] CTD PMID:20229525 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
ISO diallyl disulfide results in decreased expression of CCNB1 protein
diallyl disulfide results in increased expression of CCNB1 protein
CTD PMID:16691315 PMID:19202565 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnc cyclin C multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CCNC mRNA CTD PMID:31077537 NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO diallyl disulfide results in decreased expression of CDH1 mRNA; diallyl disulfide results in decreased expression of CDH1 protein CTD PMID:20600798 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdhr1 cadherin-related family member 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CDHR1 mRNA CTD PMID:31077537 NCBI chr16:12,843,436...12,863,321
Ensembl chr16:12,843,437...12,863,396
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO diallyl disulfide results in decreased expression of CDK1 protein CTD PMID:16691315 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdkal1 CDK5 regulatory subunit associated protein 1-like 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CDKAL1 mRNA CTD PMID:31077537 NCBI chr17:34,718,680...34,769,614
Ensembl chr17:34,718,687...35,407,524
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CDKN2B mRNA CTD PMID:31077537 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Cldn2 claudin 2 decreases expression ISO diallyl disulfide results in decreased expression of CLDN2 mRNA; diallyl disulfide results in decreased expression of CLDN2 protein CTD PMID:20600798 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838
JBrowse link
G Cldn3 claudin 3 decreases expression ISO diallyl disulfide results in decreased expression of CLDN3 mRNA; diallyl disulfide results in decreased expression of CLDN3 protein CTD PMID:20600798 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
JBrowse link
G Cldn4 claudin 4 decreases expression ISO diallyl disulfide results in decreased expression of CLDN4 mRNA; diallyl disulfide results in decreased expression of CLDN4 protein CTD PMID:20600798 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
JBrowse link
G Cldn5 claudin 5 decreases expression ISO diallyl disulfide results in decreased expression of CLDN5 mRNA; diallyl disulfide results in decreased expression of CLDN5 protein CTD PMID:20600798 NCBI chr11:82,212,822...82,214,248 JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression ISO diallyl disulfide results in decreased expression of CREB1 protein modified form CTD PMID:23732363 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
decreases phosphorylation
ISO diallyl disulfide results in increased expression of CTNNB1 mRNA; diallyl disulfide results in increased expression of CTNNB1 protein
diallyl disulfide results in decreased phosphorylation of CTNNB1 protein
CTD PMID:20600798 PMID:23663050 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity
EXP
ISO
diallyl disulfide results in increased expression of CYP1A1 protein
diallyl disulfide results in decreased activity of CYP1A1 protein
CTD PMID:16000231 PMID:18339364 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP diallyl disulfide results in increased expression of CYP1A2 protein CTD PMID:16000231 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO diallyl disulfide results in increased expression of CYP2B1 mRNA; diallyl disulfide results in increased expression of CYP2B2 mRNA CTD PMID:17353348 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions
decreases activity
ISO
EXP
diallyl disulfide results in decreased expression of CYP2E1 protein
diallyl disulfide inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]
diallyl disulfide results in decreased activity of CYP2E1 protein
[diallyl disulfide results in decreased expression of CYP2E1 protein] which results in decreased metabolism of and results in decreased susceptibility to Trichloroethylene
CTD PMID:10774820 PMID:16000231 PMID:18339364 PMID:19325051 PMID:24293383 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP diallyl disulfide results in increased expression of CYP3A2 protein CTD PMID:16000231 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dbr1 debranching RNA lariats 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of DBR1 mRNA CTD PMID:31077537 NCBI chr 8:100,139,039...100,150,768
Ensembl chr 8:100,139,034...100,151,030
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein decreases localization ISO diallyl disulfide results in decreased localization of DIABLO protein CTD PMID:17647244 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Dus2 dihydrouridine synthase 2 decreases expression
multiple interactions
EXP diallyl disulfide results in decreased expression of DUS2 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of DUS2 mRNA
CTD PMID:31077537 NCBI chr19:33,906,517...33,954,922
Ensembl chr19:33,911,750...33,954,709
JBrowse link
G Exo1 exonuclease 1 increases expression
multiple interactions
EXP diallyl disulfide results in increased expression of EXO1 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of EXO1 mRNA
CTD PMID:31077537 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of FOSL1 mRNA CTD PMID:31077537 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] CTD PMID:24293383 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions
ISO diallyl disulfide results in increased expression of GDF15 protein
TP53 protein affects the reaction [diallyl disulfide results in increased expression of GDF15 protein]
CTD PMID:11925476 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:24293383 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Grb2 growth factor receptor bound protein 2 affects expression
decreases expression
ISO diallyl disulfide affects the expression of GRB2 protein
diallyl disulfide results in decreased expression of GRB2 protein
CTD PMID:21695758 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Grhl1 grainyhead-like transcription factor 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of GRHL1 mRNA CTD PMID:31077537 NCBI chr 6:41,207,325...41,257,516
Ensembl chr 6:41,207,348...41,254,301
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO diallyl disulfide results in increased phosphorylation of GSK3B protein CTD PMID:23663050 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein] CTD PMID:24293383 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of HES1 mRNA CTD PMID:31077537 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [Carbon Tetrachloride co-treated with diallyl disulfide] results in increased expression of HMOX1 protein; diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA] CTD PMID:24293383 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
EXP diallyl disulfide results in increased expression of HSPA1A mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of HSPA1A mRNA
CTD PMID:31077537
G Hsph1 heat shock protein family H (Hsp110) member 1 decreases expression
multiple interactions
EXP diallyl disulfide results in decreased expression of HSPH1 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of HSPH1 mRNA
CTD PMID:31077537 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression
multiple interactions
EXP diallyl disulfide results in increased expression of ID1 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of ID1 mRNA
CTD PMID:31077537 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions
increases expression
EXP [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of ID2 mRNA
diallyl disulfide results in increased expression of ID2 mRNA
CTD PMID:31077537 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of ID3 mRNA CTD PMID:31077537 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of ITGB1BP1 mRNA CTD PMID:31077537 NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO diallyl disulfide results in increased phosphorylation of JUN protein CTD PMID:14522920 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase increases expression ISO diallyl disulfide results in increased expression of KIT protein CTD PMID:23663050 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Klf2 Kruppel-like factor 2 increases expression
multiple interactions
EXP diallyl disulfide results in increased expression of KLF2 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of KLF2 mRNA
CTD PMID:31077537 NCBI chr16:17,521,773...17,523,723
Ensembl chr16:17,514,552...17,523,944
JBrowse link
G Malsu1 mitochondrial assembly of ribosomal large subunit 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of MALSU1 mRNA CTD PMID:31077537 NCBI chr 4:78,051,090...78,059,913
Ensembl chr 4:78,051,059...78,059,905
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 affects expression ISO diallyl disulfide affects the expression of MAP2K7 protein CTD PMID:21695758 NCBI chr12:2,591,312...2,604,211
Ensembl chr12:2,591,219...2,604,222
JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 affects expression ISO diallyl disulfide affects the expression of MAP3K3 protein CTD PMID:21695758 NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
decreases expression
multiple interactions
EXP
ISO
diallyl disulfide results in increased phosphorylation of MAPK1 protein
diallyl disulfide results in decreased expression of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diallyl disulfide results in increased phosphorylation of MAPK1 protein]
CTD PMID:17263507 PMID:21695758 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
decreases expression
multiple interactions
EXP
ISO
diallyl disulfide results in increased phosphorylation of MAPK3 protein
diallyl disulfide results in decreased expression of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diallyl disulfide results in increased phosphorylation of MAPK3 protein]
CTD PMID:17263507 PMID:21695758 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO diallyl disulfide results in increased phosphorylation of MAPK8 protein
diallyl disulfide results in increased phosphorylation of and results in increased activity of MAPK8 protein
CTD PMID:14522920 PMID:17647244 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of MDM2 mRNA CTD PMID:31077537 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO diallyl disulfide results in decreased expression of and results in decreased activity of MMP2 protein
diallyl disulfide results in decreased expression of MMP2 mRNA; diallyl disulfide results in decreased expression of MMP2 protein
CTD PMID:20600798 PMID:21695758 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO diallyl disulfide results in decreased expression of MMP7 protein CTD PMID:21695758 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
affects expression
decreases expression
ISO diallyl disulfide results in decreased expression of and results in decreased activity of MMP9 protein
diallyl disulfide affects the expression of MMP9 protein
diallyl disulfide results in decreased expression of MMP9 mRNA
CTD PMID:20600798 PMID:21695758 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mogs mannosyl-oligosaccharide glucosidase multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of MOGS mRNA CTD PMID:31077537 NCBI chr 4:115,621,623...115,625,026
Ensembl chr 4:115,621,623...115,625,032
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of and affects the localization of NFE2L2 protein] CTD PMID:24293383 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
increases expression
multiple interactions
ISO
EXP
diallyl disulfide results in increased phosphorylation of NFKBIA protein
diallyl disulfide results in increased expression of NFKBIA mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of NFKBIA mRNA
CTD PMID:23663050 PMID:31077537 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 affects expression ISO diallyl disulfide affects the expression of NOS2 protein CTD PMID:21695758 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
increases phosphorylation
decreases degradation
ISO diallyl disulfide promotes the reaction [NOS3 protein binds to CAV1 protein]; wortmannin inhibits the reaction [diallyl disulfide results in increased phosphorylation of NOS3 protein]
diallyl disulfide results in increased expression of NOS3 protein
diallyl disulfide results in decreased degradation of NOS3 protein
CTD PMID:20229525 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
multiple interactions
EXP diallyl disulfide results in increased activity of NQO1 protein
diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA]; diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 protein]
CTD PMID:8339252 PMID:24293383 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:30677442 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of PMP22 mRNA CTD PMID:31077537 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of PPP3CA mRNA CTD PMID:31077537 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression ISO diallyl disulfide affects the expression of PTGS2 protein CTD PMID:21695758 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sesn2 sestrin 2 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of SESN2 mRNA CTD PMID:31077537 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Sfn stratifin multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of SFN mRNA CTD PMID:31077537 Ensembl chr 5:145,826,201...145,831,314 JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO diallyl disulfide results in decreased expression of SNAI1 mRNA; diallyl disulfide results in decreased expression of SNAI1 protein CTD PMID:20600798 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD1 mRNA] CTD PMID:24293383 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Stag1 stromal antigen 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of STAG1 mRNA CTD PMID:31077537 NCBI chr 8:101,179,039...101,564,684
Ensembl chr 8:101,179,039...101,564,677
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of SUMO1 mRNA CTD PMID:31077537 NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761
JBrowse link
G Tfdp2 transcription factor Dp-2 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of TFDP2 mRNA CTD PMID:31077537 NCBI chr 8:96,760,459...96,901,466
Ensembl chr 8:96,760,504...96,896,682
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO diallyl disulfide results in increased expression of TIMP1 mRNA CTD PMID:20600798 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO diallyl disulfide results in increased expression of TIMP2 mRNA CTD PMID:20600798 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP9 protein]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:30677442 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO
EXP
Acetylcysteine inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein]; Glutathione inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein]; TP53 protein affects the reaction [diallyl disulfide results in increased expression of GDF15 protein]
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of TP53 mRNA
CTD PMID:11925476 PMID:19202565 PMID:31077537 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tsg101 tumor susceptibility 101 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of TSG101 mRNA CTD PMID:31077537 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554
JBrowse link
G Ube2h ubiquitin-conjugating enzyme E2H multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of UBE2H mRNA CTD PMID:31077537 NCBI chr 4:58,834,674...58,930,156
Ensembl chr 4:58,834,674...58,930,156
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases activity EXP diallyl disulfide results in increased activity of UGT1A1 protein CTD PMID:8339252 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO diallyl disulfide results in decreased expression of XIAP protein CTD PMID:17647244 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      biological role 19757
        antimicrobial agent 17401
          antifungal agent 15099
            diallyl disulfide 95
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            heteroorganic entity 19280
                              organochalcogen compound 19051
                                organosulfur compound 15272
                                  organic disulfide 755
                                    diallyl disulfide 95
paths to the root