diallyl disulfide - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	diallyl disulfide	go back to main search page
Accession:	CHEBI:4488	browse the term
Definition:	An organic disulfide where the organic group specified is allyl. It has been isolated from garlic and other species of the genus Allium.
Synonyms:	exact_synonym:	3-(prop-2-en-1-yldisulfanyl)prop-1-ene
	related_synonym:	2-propenyl disulphide; 3,3'-disulfanediylbis(prop-1-ene); 3,3'-dithiobis(prop-1-ene); 3-(allyldisulfanyl)-1-propene; 4,5-dithia-1,7-octadiene; Formula=C6H10S2; InChI=1S/C6H10S2/c1-3-5-7-8-6-4-2/h3-4H,1-2,5-6H2; InChIKey=PFRGXCVKLLPLIP-UHFFFAOYSA-N; SMILES=C=CCSSCC=C; allyl disulfide; diallyl disulphide
	xref:	CAS:2179-57-9; Gmelin:217847; HMDB:HMDB0033966; KEGG:C08369; KNApSAcK:C00001243
	xref_mesh:	MESH:C028009
	xref:	PMID:11375895; PMID:16462049; PMID:17534841; Reaxys:1699241; Wikipedia:Diallyl_disulfide

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Genes (202)

diallyl disulfide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression

diallyl disulfide results in increased expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

decreases expression
increases expression

diallyl disulfide results in decreased expression of ABCC1 mRNA
diallyl disulfide results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 3

increases expression
affects expression

diallyl disulfide results in increased expression of ABCC3 mRNA
diallyl disulfide affects the expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

increases expression
decreases expression

diallyl disulfide results in increased expression of ABCC4 mRNA
diallyl disulfide results in decreased expression of ABCC4 mRNA

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily C member 6

decreases expression
increases expression

diallyl disulfide results in decreased expression of ABCC6 mRNA
diallyl disulfide results in increased expression of ABCC6 mRNA

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

ADAM metallopeptidase domain 32

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of ADAM32 mRNA]

NCBI chr16:67,102,384...67,212,163
Ensembl chr16:67,102,320...67,212,161

G

adhesion G protein-coupled receptor B3

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of ADGRB3 mRNA]

NCBI chr 9:27,421,168...28,148,979
Ensembl chr 9:27,421,168...28,148,855

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

multiple interactions

diallyl disulfide inhibits the reaction [Ethanol results in decreased expression of ADH1 protein]

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

adenosine A1 receptor

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of ADORA1 mRNA]

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

androgen-dependent TFPI-regulating protein

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of ADTRP mRNA]

NCBI chr17:22,907,758...22,993,834
Ensembl chr17:22,930,740...22,993,826

G

AKT serine/threonine kinase 1

increases phosphorylation

diallyl disulfide results in increased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 2 family member

multiple interactions

diallyl disulfide inhibits the reaction [Ethanol results in decreased expression of ALDH2 protein]

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

alkaline phosphatase, placental

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of ALPP mRNA]

NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606

G

angiogenin

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of ANG mRNA]

NCBI chr15:24,312,711...24,323,361

G

angiopoietin 4

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of ANGPT4 mRNA]

NCBI chr 3:140,420,389...140,454,213
Ensembl chr 3:140,420,389...140,453,583

G

Rho GDP dissociation inhibitor beta

multiple interactions
decreases expression

ARHGDIB protein affects the reaction [diallyl disulfide results in decreased expression of CD33 protein]; ARHGDIB protein affects the reaction [diallyl disulfide results in increased expression of ITGAM protein]; ARHGDIB protein inhibits the reaction [diallyl disulfide results in decreased expression of LIMK1 protein]; ARHGDIB protein inhibits the reaction [diallyl disulfide results in decreased expression of PAK1 protein]; ARHGDIB protein inhibits the reaction [diallyl disulfide results in decreased expression of RAC1 protein]
diallyl disulfide results in decreased expression of ARHGDIB mRNA; diallyl disulfide results in decreased expression of ARHGDIB protein

NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658

G

activating transcription factor 3

increases expression

diallyl disulfide results in increased expression of ATF3 protein

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

BCL2 associated X, apoptosis regulator

increases expression

diallyl disulfide results in increased expression of BAX mRNA; diallyl disulfide results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

diallyl disulfide results in decreased expression of BCL2 protein
diallyl disulfide results in decreased expression of BCL2 mRNA; diallyl disulfide results in decreased expression of BCL2 protein

PMID:14522920 PMID:16052692 PMID:17647244 PMID:30677442

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

brain-derived neurotrophic factor

decreases expression

diallyl disulfide results in decreased expression of BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

baculoviral IAP repeat-containing 3

decreases expression

diallyl disulfide results in decreased expression of BIRC3 protein

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

decreases expression

diallyl disulfide results in decreased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

similar to human chromosome 7 open reading frame 57

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of C7ORF57 mRNA]

NCBI chr14:83,748,478...83,768,293
Ensembl chr14:83,748,478...83,767,435

G

calcitonin-related polypeptide, beta

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of CALCB mRNA]

NCBI chr 1:168,965,383...168,970,259
Ensembl chr 1:168,966,465...168,970,125

G

cathelicidin antimicrobial peptide

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of CAMP mRNA]

NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543

G

caspase 1

multiple interactions

diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]; diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of CASP1 protein modified form]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of CASP1 protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased cleavage of CASP1 protein]

PMID:34896185 PMID:35526736

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

increases activity
multiple interactions
increases cleavage

diallyl disulfide results in increased activity of CASP3 protein
diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]
diallyl disulfide results in increased cleavage of CASP3 protein
diallyl disulfide inhibits the reaction [Ethanol results in increased expression of CASP3 protein]

PMID:14522920 PMID:17647244 PMID:24972622 PMID:30677442

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases activity

diallyl disulfide results in increased activity of CASP4 protein

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 8

multiple interactions
increases cleavage

diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]
diallyl disulfide results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity
multiple interactions
increases cleavage

diallyl disulfide results in increased activity of CASP9 protein
diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP9 protein]
diallyl disulfide results in increased cleavage of CASP9 protein

PMID:14522920 PMID:17647244 PMID:30677442

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

calpastatin

decreases expression

diallyl disulfide results in decreased expression of CAST mRNA; diallyl disulfide results in decreased expression of CAST protein

NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659

G

catalase

multiple interactions

diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; diallyl disulfide inhibits the reaction [Ethanol results in decreased activity of CAT protein]

PMID:24293383 PMID:24972622

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

multiple interactions

diallyl disulfide promotes the reaction [NOS3 protein binds to CAV1 protein]

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

coiled-coil domain containing 178

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of CCDC178 mRNA]

NCBI chr18:13,074,834...13,472,732
Ensembl chr18:13,075,468...13,472,160

G

C-C motif chemokine ligand 2

multiple interactions

diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin A1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of CCNA1 mRNA]

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin B1

decreases expression
increases expression

diallyl disulfide results in decreased expression of CCNB1 protein
diallyl disulfide results in increased expression of CCNB1 protein

PMID:16691315 PMID:19202565

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin C

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CCNC mRNA

NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584

G

CD1d1 molecule

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of CD1D mRNA]

NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089

G

CD33 molecule

decreases expression
multiple interactions

diallyl disulfide results in decreased expression of CD33 protein
ARHGDIB protein affects the reaction [diallyl disulfide results in decreased expression of CD33 protein]

NCBI chr 1:93,935,418...93,940,452
Ensembl chr 1:93,930,971...93,950,149

G

cadherin 1

decreases expression

diallyl disulfide results in decreased expression of CDH1 mRNA; diallyl disulfide results in decreased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin-related family member 1

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CDHR1 mRNA

NCBI chr16:12,843,436...12,863,321
Ensembl chr16:12,843,437...12,863,396

G

cyclin-dependent kinase 1

decreases expression

diallyl disulfide results in decreased expression of CDK1 protein

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

CDK5 regulatory subunit associated protein 1-like 1

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CDKAL1 mRNA

NCBI chr17:34,718,701...35,271,276
Ensembl chr17:34,718,687...35,407,524

G

cyclin-dependent kinase inhibitor 2B

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CDKN2B mRNA

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

CERK like autophagy regulator

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of CERKL mRNA]

NCBI chr 3:64,238,714...64,344,695
Ensembl chr 3:64,237,522...64,340,675

G

complement factor D

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of CFD mRNA]

NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053

G

claudin 2

decreases expression

diallyl disulfide results in decreased expression of CLDN2 mRNA; diallyl disulfide results in decreased expression of CLDN2 protein

NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838

G

claudin 3

decreases expression

diallyl disulfide results in decreased expression of CLDN3 mRNA; diallyl disulfide results in decreased expression of CLDN3 protein

NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001

G

claudin 4

decreases expression

diallyl disulfide results in decreased expression of CLDN4 mRNA; diallyl disulfide results in decreased expression of CLDN4 protein

NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436

G

claudin 5

decreases expression

diallyl disulfide results in decreased expression of CLDN5 mRNA; diallyl disulfide results in decreased expression of CLDN5 protein

NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992

G

coronin 6

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of CORO6 mRNA]

NCBI chr10:62,311,552...62,319,659
Ensembl chr10:62,311,660...62,319,659

G

carnitine palmitoyltransferase 1A

multiple interactions

diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in decreased expression of CPT1A protein]; diallyl disulfide inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

cAMP responsive element binding protein 1

decreases expression

diallyl disulfide results in decreased expression of CREB1 protein modified form

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

catenin beta 1

increases expression
decreases phosphorylation

diallyl disulfide results in increased expression of CTNNB1 mRNA; diallyl disulfide results in increased expression of CTNNB1 protein
diallyl disulfide results in decreased phosphorylation of CTNNB1 protein

PMID:20600798 PMID:23663050

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 14

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of CXCL14 mRNA]

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases activity

diallyl disulfide results in increased expression of CYP1A1 protein
diallyl disulfide results in decreased activity of CYP1A1 protein

PMID:16000231 PMID:18339364

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

diallyl disulfide results in increased expression of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

diallyl disulfide results in increased expression of CYP2B1 mRNA; diallyl disulfide results in increased expression of CYP2B2 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression
multiple interactions
decreases activity

diallyl disulfide results in decreased expression of CYP2E1 protein
[diallyl disulfide results in decreased expression of CYP2E1 protein] which results in decreased metabolism of and results in decreased susceptibility to Trichloroethylene; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]
diallyl disulfide results in decreased activity of CYP2E1 protein
diallyl disulfide inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]

PMID:10774820 PMID:16000231 PMID:18339364 PMID:19325051 PMID:24293383 More...

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

diallyl disulfide results in increased expression of CYP3A2 protein

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

debranching RNA lariats 1

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of DBR1 mRNA

NCBI chr 8:100,139,039...100,150,768
Ensembl chr 8:100,139,034...100,151,030

G

DC-STAMP domain containing 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of DCST1 mRNA]

NCBI chr 2:174,765,203...174,784,023
Ensembl chr 2:174,765,350...174,781,806

G

diablo, IAP-binding mitochondrial protein

decreases localization

diallyl disulfide results in decreased localization of DIABLO protein

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

G

dorsal inhibitory axon guidance protein

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of DRAXIN mRNA]

NCBI chr 5:158,530,149...158,563,457
Ensembl chr 5:158,530,342...158,564,483

G

dihydrouridine synthase 2

decreases expression
multiple interactions

diallyl disulfide results in decreased expression of DUS2 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of DUS2 mRNA

NCBI chr19:33,906,517...33,954,922
Ensembl chr19:33,911,750...33,954,709

G

endothelin 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of EDN1 mRNA]

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

extracellular leucine-rich repeat and fibronectin type III domain containing 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of ELFN1 mRNA]

NCBI chr12:14,660,049...14,725,709
Ensembl chr12:14,660,083...14,724,580

G

exonuclease 1

increases expression
multiple interactions

diallyl disulfide results in increased expression of EXO1 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of EXO1 mRNA

NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654

G

EYA transcriptional coactivator and phosphatase 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of EYA1 mRNA]

NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483

G

fatty acid synthase

multiple interactions

diallyl disulfide inhibits the reaction [Ethanol results in decreased expression of FASN protein]

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibroblast growth factor receptor 3

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of FGFR3 mRNA]

NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341

G

FOS like 1, AP-1 transcription factor subunit

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box C2

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of FOXC2 mRNA]

NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737

G

growth arrest-specific 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of GAS1 mRNA]

NCBI chr17:4,482,168...4,485,153

G

guanylate binding protein 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of GBP1 mRNA]

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]
[diallyl disulfide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of GCLC protein; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of GCLC mRNA]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of GCLC protein]; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of GCLC mRNA]]
diallyl disulfide results in increased expression of GCLC mRNA; diallyl disulfide results in increased expression of GCLC protein

PMID:24293383 PMID:34887701 PMID:34896185 PMID:35526736

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

multiple interactions
increases expression

diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GCLM mRNA]]
diallyl disulfide results in increased expression of GCLM mRNA

PMID:34887701 PMID:34896185

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

growth differentiation factor 15

increases expression
multiple interactions

diallyl disulfide results in increased expression of GDF15 protein
TP53 protein affects the reaction [diallyl disulfide results in increased expression of GDF15 protein]

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

growth factor independent 1 transcriptional repressor

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of GFI1 mRNA]

NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814

G

gap junction protein, alpha 5

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of GJA5 mRNA]

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

G

golgi transport 1A

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of GOLT1A mRNA]

NCBI chr13:44,760,356...44,773,123
Ensembl chr13:44,760,380...44,773,122

G

glutamic--pyruvic transaminase

multiple interactions

diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of GPT protein]

PMID:24293383 PMID:34896185

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

growth factor receptor bound protein 2

affects expression
decreases expression

diallyl disulfide affects the expression of GRB2 protein
diallyl disulfide results in decreased expression of GRB2 protein

NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309

G

grainyhead-like transcription factor 1

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of GRHL1 mRNA

NCBI chr 6:41,207,325...41,257,516
Ensembl chr 6:41,207,348...41,254,301

G

glycogen synthase kinase 3 beta

increases phosphorylation

diallyl disulfide results in increased phosphorylation of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

multiple interactions

diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein]; diallyl disulfide inhibits the reaction [Ethanol results in decreased activity of GSR protein]

PMID:24293383 PMID:24972622

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

heparin-binding EGF-like growth factor

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of HBEGF mRNA]

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

hes family bHLH transcription factor 1

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of HES1 mRNA

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

heme oxygenase 1

multiple interactions
increases expression

[Carbon Tetrachloride co-treated with diallyl disulfide] results in increased expression of HMOX1 protein; diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]
[diallyl disulfide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of HMOX1 protein; diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]
diallyl disulfide results in increased expression of HMOX1 mRNA; diallyl disulfide results in increased expression of HMOX1 protein

PMID:24293383 PMID:34887701 PMID:34896185

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

homeo box B9

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of HOXB9 mRNA]

NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818

G

heat shock protein family A (Hsp70) member 1A

increases expression
multiple interactions

diallyl disulfide results in increased expression of HSPA1A mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family H (Hsp110) member 1

decreases expression
multiple interactions

diallyl disulfide results in decreased expression of HSPH1 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of HSPH1 mRNA

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

inhibitor of DNA binding 1

increases expression
multiple interactions

diallyl disulfide results in increased expression of ID1 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

inhibitor of DNA binding 2

multiple interactions
increases expression

[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of ID2 mRNA
diallyl disulfide results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

inhibitor of DNA binding 3

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

intermediate filament family orphan 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of IFFO1 mRNA]

NCBI chr 4:157,945,075...157,962,302
Ensembl chr 4:157,945,107...157,962,302

G

interleukin 11

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of IL11 mRNA]

NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129

G

interleukin 1 beta

multiple interactions

diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; diallyl disulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of IL1B protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]

PMID:34896185 PMID:35526736 PMID:36796188

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of IL1RL1 mRNA]

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 1 receptor antagonist

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of IL1RN mRNA]

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 6

multiple interactions

diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]
diallyl disulfide inhibits the reaction [Ethanol results in increased expression of IL6 protein]

PMID:24972622 PMID:34896185

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibitory synaptic factor 2A

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of INSYN2A mRNA]

NCBI chr 1:189,697,856...189,753,194
Ensembl chr 1:189,697,878...189,752,922

G

integrin subunit alpha M

increases expression
multiple interactions

diallyl disulfide results in increased expression of ITGAM protein
ARHGDIB protein affects the reaction [diallyl disulfide results in increased expression of ITGAM protein]

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit beta 1 binding protein 1

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of ITGB1BP1 mRNA

NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037

G

junctophilin 3

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of JPH3 mRNA]

NCBI chr19:49,793,967...49,855,338
Ensembl chr19:49,793,092...49,855,338

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases phosphorylation

diallyl disulfide results in increased phosphorylation of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium inwardly-rectifying channel, subfamily J, member 2

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of KCNJ2 mRNA]

NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445

G

Kelch-like ECH-associated protein 1

multiple interactions
decreases expression

diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of KEAP1 protein]
diallyl disulfide results in decreased expression of KEAP1 protein

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

KIT proto-oncogene receptor tyrosine kinase

increases expression

diallyl disulfide results in increased expression of KIT protein

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

KLF transcription factor 2

increases expression
multiple interactions

diallyl disulfide results in increased expression of KLF2 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of KLF2 mRNA

NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944

G

kelch-like family member 10

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of KLHL10 mRNA]

NCBI chr10:85,376,442...85,392,720
Ensembl chr10:85,376,442...85,392,720

G

kallikrein related-peptidase 10

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of KLK10 mRNA]

NCBI chr 1:94,234,536...94,239,369
Ensembl chr 1:94,235,096...94,239,376

G

kynurenine 3-monooxygenase

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of KMO mRNA]

NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881

G

late cornified envelope 1E

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of LCE1E mRNA]

NCBI chr 2:178,462,100...178,463,433
Ensembl chr 2:178,462,100...178,463,433

G

lymphoid enhancer binding factor 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of LEF1 mRNA]

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

LIM domain kinase 1

multiple interactions
decreases expression

ARHGDIB protein inhibits the reaction [diallyl disulfide results in decreased expression of LIMK1 protein]

NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606

G

MAM and LDL receptor class A domain containing 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of MALRD1 mRNA]

NCBI chr17:78,418,819...79,131,015
Ensembl chr17:78,418,819...79,131,016

G

mitochondrial assembly of ribosomal large subunit 1

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of MALSU1 mRNA

NCBI chr 4:78,051,090...78,059,913
Ensembl chr 4:78,051,059...78,059,905

G

mitogen activated protein kinase kinase 7

affects expression

diallyl disulfide affects the expression of MAP2K7 protein

NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222

G

mitogen activated protein kinase kinase kinase 3

affects expression

diallyl disulfide affects the expression of MAP3K3 protein

NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions
decreases expression

diallyl disulfide results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diallyl disulfide results in increased phosphorylation of MAPK1 protein]
diallyl disulfide results in decreased expression of MAPK1 protein
diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]

PMID:17263507 PMID:21695758 PMID:34896185

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions
decreases expression

diallyl disulfide results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diallyl disulfide results in increased phosphorylation of MAPK3 protein]
diallyl disulfide results in decreased expression of MAPK3 protein
diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]

PMID:17263507 PMID:21695758 PMID:34896185

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

diallyl disulfide results in increased phosphorylation of MAPK8 protein
diallyl disulfide results in increased phosphorylation of and results in increased activity of MAPK8 protein
diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]

PMID:14522920 PMID:17647244 PMID:34896185

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MDM2 proto-oncogene

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

matrix metallopeptidase 2

multiple interactions
decreases expression

diallyl disulfide results in decreased expression of and results in decreased activity of MMP2 protein
diallyl disulfide results in decreased expression of MMP2 mRNA; diallyl disulfide results in decreased expression of MMP2 protein

PMID:20600798 PMID:21695758

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 7

decreases expression

diallyl disulfide results in decreased expression of MMP7 protein

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

matrix metallopeptidase 9

multiple interactions
decreases expression
affects expression

diallyl disulfide results in decreased expression of and results in decreased activity of MMP9 protein
diallyl disulfide results in decreased expression of MMP9 mRNA
diallyl disulfide affects the expression of MMP9 protein

PMID:20600798 PMID:21695758

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mannosyl-oligosaccharide glucosidase

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of MOGS mRNA

NCBI chr 4:115,621,623...115,625,026
Ensembl chr 4:115,621,623...115,625,032

G

neutrophil cytosolic factor 2

increases expression

diallyl disulfide results in increased expression of NCF2 mRNA

NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277

G

neuralized E3 ubiquitin protein ligase 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of NEURL1 mRNA]

NCBI chr 1:246,066,830...246,152,890
Ensembl chr 1:246,067,100...246,152,903

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases degradation
decreases expression

diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of and affects the localization of NFE2L2 protein]
diallyl disulfide affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFE2L2 protein]; diallyl disulfide inhibits the reaction [Ethanol affects the expression of NFE2L2 protein]; diallyl disulfide results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of GCLC mRNA]]; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NQO1 mRNA]]; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]]; NFE2L2 protein affects the reaction [diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GCLM mRNA]]; NFE2L2 protein affects the reaction [diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]
diallyl disulfide results in decreased degradation of NFE2L2 protein
diallyl disulfide results in decreased expression of NFE2L2 mRNA

PMID:24293383 PMID:34896185 PMID:35526736

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

increases phosphorylation
multiple interactions
increases expression

diallyl disulfide results in increased phosphorylation of NFKBIA protein
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of NFKBIA mRNA
diallyl disulfide results in increased expression of NFKBIA mRNA
diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NFKBIA protein modified form]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of NFKBIA protein modified form]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein]

PMID:23663050 PMID:31077537 PMID:34896185 PMID:35526736

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NLR family, pyrin domain containing 10

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of NLRP10 mRNA]

NCBI chr 1:162,922,806...162,930,363
Ensembl chr 1:162,922,806...162,930,363

G

NLR family, pyrin domain containing 3

multiple interactions

diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of NLRP3 protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NLRP3 protein]

PMID:34896185 PMID:35526736

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

affects expression
multiple interactions

diallyl disulfide affects the expression of NOS2 protein
diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NOS2 protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]

PMID:21695758 PMID:24972622 PMID:34896185 PMID:35526736

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions
decreases degradation
increases phosphorylation
increases expression

diallyl disulfide promotes the reaction [NOS3 protein binds to CAV1 protein]; wortmannin inhibits the reaction [diallyl disulfide results in increased phosphorylation of NOS3 protein]
diallyl disulfide results in decreased degradation of NOS3 protein
diallyl disulfide results in increased expression of NOS3 protein

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NAD(P)H quinone dehydrogenase 1

increases activity
multiple interactions
increases expression

diallyl disulfide results in increased activity of NQO1 protein
diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA]; diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 protein]
diallyl disulfide results in increased expression of NQO1 mRNA; diallyl disulfide results in increased expression of NQO1 protein
diallyl disulfide inhibits the reaction [Ethanol results in increased expression of NQO1 protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NQO1 mRNA]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NQO1 protein]; diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NQO1 mRNA]]

PMID:8339252 PMID:24293383 PMID:34896185 PMID:35526736

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

neuronal regeneration related protein

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of NREP mRNA]

NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591

G

osteoclast associated Ig-like receptor

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of OSCAR mRNA]

NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758

G

p21 (RAC1) activated kinase 1

decreases expression
multiple interactions

diallyl disulfide results in decreased expression of PAK1 protein
ARHGDIB protein inhibits the reaction [diallyl disulfide results in decreased expression of PAK1 protein]

NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383

G

pappalysin 2

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of PAPPA2 mRNA]

NCBI chr13:70,873,918...71,147,874
Ensembl chr13:70,876,794...71,147,779

G

poly (ADP-ribose) polymerase 1

multiple interactions

benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

paternally expressed 10

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of PEG10 mRNA]

NCBI chr 4:32,842,441...32,855,639
Ensembl chr 4:32,848,493...32,852,621

G

phosphoglucomutase 5

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of PGM5 mRNA]

NCBI chr 1:222,325,638...222,513,434
Ensembl chr 1:222,325,643...222,513,437

G

paired immunoglobin-like type 2 receptor alpha

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of PILRA mRNA]

NCBI chr12:17,787,169...17,798,149
Ensembl chr12:17,787,127...17,798,094

G

phospholipid phosphatase 3

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of PPAP2B mRNA]

NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205

G

peripheral myelin protein 22

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of PMP22 mRNA
diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of PMP22 mRNA]

PMID:31077537 PMID:36758788

NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714

G

peroxisome proliferator activated receptor alpha

multiple interactions

diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in decreased expression of PPARA protein]; diallyl disulfide inhibits the reaction [Ethanol results in decreased expression of PPARA protein]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

protein phosphatase 3 catalytic subunit alpha

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of PPP3CA mRNA

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

prostaglandin-endoperoxide synthase 2

affects expression
multiple interactions

diallyl disulfide affects the expression of PTGS2 protein
diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]
diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of PTGS2 mRNA]

PMID:21695758 PMID:35526736 PMID:36758788

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

PYD and CARD domain containing

multiple interactions

diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of PYCARD protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of PYCARD protein]

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

peptide YY

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of PYY mRNA]

NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815

G

RAB3A, member RAS oncogene family

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of RAB3A mRNA]

NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336

G

Rac family small GTPase 1

multiple interactions
decreases expression

ARHGDIB protein inhibits the reaction [diallyl disulfide results in decreased expression of RAC1 protein]

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

reticulocalbin 3

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of RCN3 mRNA]

NCBI chr 1:95,564,503...95,573,762
Ensembl chr 1:95,564,380...95,573,725

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of RELA protein modified form]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of RELA protein modified form]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of RELA protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein]

PMID:34896185 PMID:35526736

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

regucalcin

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of RGN mRNA]

NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450

G

ras homolog family member V

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of RHOV mRNA]

NCBI chr 3:106,260,774...106,270,009
Ensembl chr 3:106,260,776...106,269,479

G

retinal pigment epithelium derived rhodopsin homolog

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of RRH mRNA]

NCBI chr 2:218,362,195...218,374,387
Ensembl chr 2:218,362,200...218,374,599

G

sphingosine-1-phosphate receptor 5

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of S1PR5 mRNA]

NCBI chr 8:19,786,676...19,791,862
Ensembl chr 8:19,786,663...19,791,795

G

sestrin 2

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of SESN2 mRNA

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

stratifin

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of SFN mRNA

NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314

G

SH2 domain containing 3C

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of SH2D3C mRNA]

NCBI chr 3:16,010,622...16,046,491
Ensembl chr 3:16,010,625...16,046,484

G

solute carrier family 1 member 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of SLC1A1 mRNA]

NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402

G

solute carrier family 6 member 6

increases expression

diallyl disulfide results in increased expression of SLC6A6 mRNA

NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875

G

snail family transcriptional repressor 1

decreases expression

diallyl disulfide results in decreased expression of SNAI1 mRNA; diallyl disulfide results in decreased expression of SNAI1 protein

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

superoxide dismutase 1

multiple interactions

diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD1 mRNA]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

sprouty-related, EVH1 domain containing 3

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of SPRED3 mRNA]

NCBI chr 1:84,458,779...84,470,425
Ensembl chr 1:84,459,314...84,470,249

G

serine palmitoyltransferase, small subunit B

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of SPTSSB mRNA]

NCBI chr 2:154,133,728...154,162,127
Ensembl chr 2:154,133,733...154,163,120

G

sequestosome 1

increases expression

diallyl disulfide results in increased expression of SQSTM1 mRNA

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 1

multiple interactions

diallyl disulfide inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

STAG1 cohesin complex component

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of STAG1 mRNA

NCBI chr 8:101,179,039...101,564,684
Ensembl chr 8:101,179,039...101,564,677

G

STEAP4 metalloreductase

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of STEAP4 mRNA]

NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859

G

small ubiquitin-like modifier 1

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of SUMO1 mRNA

NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761

G

synaptotagmin 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of SYT1 mRNA]

NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803

G

T-box transcription factor 2

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of TBX2 mRNA]

NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529

G

transcription factor Dp-2

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of TFDP2 mRNA

NCBI chr 8:96,760,459...96,901,466
Ensembl chr 8:96,760,504...96,896,682

G

Thy-1 cell surface antigen

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of THY1 mRNA]

NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659

G

TIMP metallopeptidase inhibitor 1

increases expression

diallyl disulfide results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

increases expression

diallyl disulfide results in increased expression of TIMP2 mRNA

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

transmembrane protein 200A

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of TMEM200A mRNA]

NCBI chr 1:19,323,646...19,408,324
Ensembl chr 1:19,323,829...19,406,453

G

transmembrane protein 217

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of TMEM217 mRNA]

NCBI chr20:7,584,177...7,619,023
Ensembl chr20:7,592,627...7,619,111
Ensembl chr20:7,592,627...7,619,111

G

transmembrane protein 45b

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of TMEM45B mRNA]

NCBI chr 8:29,865,276...29,910,453
Ensembl chr 8:29,865,278...29,910,453

G

transmembrane protein 88

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of TMEM88 mRNA]

NCBI chr10:54,118,752...54,120,447
Ensembl chr10:54,118,752...54,120,447

G

transmembrane serine protease 15

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of TMPRSS15 mRNA]

NCBI chr11:17,677,741...17,802,255
Ensembl chr11:17,677,741...17,802,255

G

tumor necrosis factor

multiple interactions
decreases secretion

diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased secretion of TNF protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]]
diallyl disulfide results in decreased secretion of TNF protein
diallyl disulfide inhibits the reaction [Ethanol results in increased expression of TNF protein]

PMID:24972622 PMID:34896185 PMID:35526736

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 10

multiple interactions

benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP9 protein]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

tumor protein p53

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein]; Glutathione inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein]; TP53 protein affects the reaction [diallyl disulfide results in increased expression of GDF15 protein]
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of TP53 mRNA

PMID:11925476 PMID:19202565 PMID:31077537

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

triggering receptor expressed on myeloid cells 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of TREM1 mRNA]

NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203

G

tripartite motif containing 15

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of TRIM15 mRNA]

NCBI chr20:1,700,905...1,710,249
Ensembl chr20:1,700,905...1,710,249

G

tumor susceptibility 101

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of TSG101 mRNA

NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554

G

tubulin, beta 4A class IVa

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of TUBB4A mRNA]

NCBI chr 9:1,917,841...1,925,286
Ensembl chr 9:1,917,845...1,925,291

G

thioredoxin reductase 1

multiple interactions

diallyl disulfide inhibits the reaction [Ethanol results in decreased expression of TXNRD1 protein]

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

ubiquitin-conjugating enzyme E2H

multiple interactions

[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of UBE2H mRNA

NCBI chr 4:58,834,674...58,930,156
Ensembl chr 4:58,834,674...58,930,156

G

UDP glucuronosyltransferase family 1 member A1

increases activity

diallyl disulfide results in increased activity of UGT1A1 protein

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

unc-79 homolog, NALCN channel complex subunit

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of UNC79 mRNA]

NCBI chr 6:122,082,369...122,327,641
Ensembl chr 6:122,080,308...122,327,591

G

uridine phosphorylase 1

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in increased expression of UPP1 mRNA]

NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462

G

vasohibin 2

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of VASH2 mRNA]

NCBI chr13:102,529,718...102,561,204
Ensembl chr13:102,529,719...102,560,391

G

von Willebrand factor A domain containing 5A

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of VWA5A mRNA]

NCBI chr 8:38,815,176...38,848,674
Ensembl chr 8:38,815,210...38,839,112

G

X-linked inhibitor of apoptosis

decreases expression

diallyl disulfide results in decreased expression of XIAP protein

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

G

zinc finger protein 667

multiple interactions

diallyl disulfide inhibits the reaction [tobacco tar analog results in decreased expression of ZNF667 mRNA]

NCBI chr 1:67,601,803...67,622,041
Ensembl chr 1:67,601,807...67,622,041

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19901
role	19871
biological role	19869
antimicrobial agent	18272
antifungal agent	17184
diallyl disulfide	202
Path 2
Term	Annotations
CHEBI ontology	19901
subatomic particle	19899
composite particle	19899
hadron	19899
baryon	19899
nucleon	19899
atomic nucleus	19899
atom	19899
main group element atom	19838
p-block element atom	19838
carbon group element atom	19778
carbon atom	19775
organic molecular entity	19775
heteroorganic entity	19534
organochalcogen compound	19295
organosulfur compound	17471
organic disulfide	4849
diallyl disulfide	202

paths to the root