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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diacetylmonoxime
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Accession:CHEBI:4480 term browser browse the term
Definition:A ketoxime obtained via formal condensation of butane-2,3-dione with hydroxylamine. It is a reversible myosin ATPase inhibitor.
Synonyms:exact_synonym: 3-(hydroxyimino)butan-2-one
 related_synonym: 2,3-Butanedione monoxime;   2,3-butadione monooxime;   2,3-butanedione 3-monoxime;   2,3-butanedione oxime;   2,3-butanedione-2-monoxime;   2-hydroxyimino-3-butanone;   2-oximino-3-butanone;   3-oxo-2-butanone oxime;   DAM;   DAM (oxime);   Formula=C4H7NO2;   InChI=1S/C4H7NO2/c1-3(5-7)4(2)6/h7H,1-2H3;   InChIKey=FSEUPUDHEBLWJY-UHFFFAOYSA-N;   SMILES=CC(=O)C(C)=NO;   biacetyl monooxime;   biacetyl monoxime;   diacetyl monooxime;   diacetyl monoxime;   isonitrosoethyl methyl ketone
 xref: AGR:IND43930971;   AGR:IND44021913;   CAS:57-71-6;   Chemspider:4911363;   HMDB:HMDB0245382;   KEGG:C07509
 xref_mesh: MESH:C004717
 xref: PMID:11120921;   PMID:11437739;   PMID:1145631;   PMID:12606257;   PMID:12630704;   PMID:12634934;   PMID:12958029;   PMID:15452414;   PMID:15490227;   PMID:15509860;   PMID:15868207;   PMID:16142696;   PMID:16405454;   PMID:19523992;   PMID:22037192;   PMID:22497862;   PMID:25382940;   PMID:25450568;   PMID:26116551;   PMID:26733241;   PMID:27041248;   PMID:27222176;   PMID:34056790;   PMID:34147606;   PMID:6243361;   Reaxys:605582;   Wikipedia:Diacetyl_monoxime


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diacetylmonoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO diacetylmonoxime inhibits the reaction [cyclohexyl methylphosphonofluoridate binds to and results in decreased activity of ACHE protein]; diacetylmonoxime inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; diacetylmonoxime inhibits the reaction [Sarin binds to and results in decreased activity of ACHE protein]; diacetylmonoxime inhibits the reaction [tabun results in decreased activity of ACHE protein]; diacetylmonoxime inhibits the reaction [VX binds to and results in decreased activity of ACHE protein] CTD PMID:22960624 PMID:22975155 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
affects localization		 EXP
ISO		 diacetylmonoxime results in decreased expression of ACTA2
diacetylmonoxime affects the localization of ACTA2 protein		 CTD PMID:11591817 PMID:11868461 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP diacetylmonoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]; diacetylmonoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein] CTD PMID:1276991 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO diacetylmonoxime inhibits the reaction [Demecolcine results in increased activity of CASP3 protein] CTD PMID:12530016 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO diacetylmonoxime results in decreased expression of CDKN1A protein CTD PMID:15252113 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO diacetylmonoxime results in increased expression of CDKN1B protein CTD PMID:15252113 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Myod1 myogenic differentiation 1 decreases expression ISO diacetylmonoxime results in decreased expression of MYOD1 protein CTD PMID:15252113 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554 		JBrowse link
G Myog myogenin decreases expression ISO diacetylmonoxime results in decreased expression of MYOG protein CTD PMID:15252113 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039 		JBrowse link
G Tf transferrin decreases uptake ISO diacetylmonoxime results in decreased uptake of TF protein CTD PMID:16563724 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          enzyme reactivator 13
            cholinesterase reactivator 13
              diacetylmonoxime 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            oxime 429
                              ketoxime 353
                                diacetylmonoxime 9
paths to the root