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ONTOLOGY REPORT - ANNOTATIONS


Term:dextromethorphan
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Accession:CHEBI:4470 term browser browse the term
Definition:An organic heterotetracyclic compound that is morphinan substituted by a methoxy group at position 3 and a methyl group at position 7. It is used as an antitussive drug for suppressing cough.
Synonyms:exact_synonym: 3-methoxy-17-methylmorphinan
 related_synonym: DXM;   Formula=C18H25NO;   InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m0/s1;   InChIKey=MKXZASYAUGDDCJ-CGTJXYLNSA-N;   SMILES=[H][C@@]12CCCC[C@@]11CCN(C)[C@@H]2Cc2ccc(OC)cc12;   d-Methorphan;   delta-Methorphan
 xref: CAS:125-71-3 "ChemIDplus";   CAS:125-71-3 "KEGG COMPOUND";   CAS:125-71-3 "NIST Chemistry WebBook";   DrugBank:DB00514;   HMDB:HMDB0001920;   KEGG:C06947;   KEGG:D03742
 xref_mesh: MESH:D003915
 xref: PMID:17461892 "Europe PMC";   PMID:18198471 "Europe PMC";   PMID:24269965 "Europe PMC";   Reaxys:88549 "Reaxys";   Wikipedia:Dextromethorphan


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dextromethorphan term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6480464
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 JBrowse link 1 258,796,624 258,877,023 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 JBrowse link 7 123,625,641 123,630,045 RGD:6480464
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 JBrowse link 7 123,651,827 123,655,896 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 JBrowse link 12 11,053,888 11,082,742 RGD:6480464
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 JBrowse link 6 132,242,328 132,273,788 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 3 2,507,745 2,534,664 RGD:6480464
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:6480464
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 4 169,541,620 170,000,216 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Nat2 N-acetyltransferase 2 JBrowse link 16 23,960,709 23,991,570 RGD:6480464
G Oprd1 opioid receptor, delta 1 JBrowse link 5 150,288,126 150,323,063 RGD:6480464
G Oprk1 opioid receptor, kappa 1 JBrowse link 5 13,742,655 13,760,460 RGD:6480464
G Oprm1 opioid receptor, mu 1 JBrowse link 1 43,454,803 43,704,948 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Sigmar1 sigma non-opioid intracellular receptor 1 JBrowse link 5 58,121,824 58,124,687 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Sord sorbitol dehydrogenase JBrowse link 3 114,176,127 114,207,368 RGD:6480464
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19614
    role 19557
      biological role 19550
        xenobiotic 18180
          dextromethorphan 38
            dextromethorphan hydrobromide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19614
    subatomic particle 19610
      composite particle 19610
        hadron 19610
          baryon 19610
            nucleon 19610
              atomic nucleus 19610
                atom 19610
                  main group element atom 19489
                    p-block element atom 19489
                      carbon group element atom 19362
                        carbon atom 19354
                          organic molecular entity 19354
                            heteroorganic entity 18925
                              organonitrogen compound 18082
                                alkaloid 5190
                                  isoquinoline alkaloid 1117
                                    morphinane alkaloid 655
                                      dextromethorphan 38
                                        dextromethorphan hydrobromide 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.