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ONTOLOGY REPORT - ANNOTATIONS


Term:dexmedetomidine
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Accession:CHEBI:4466 term browser browse the term
Definition:A medetomidine that has formula C13H16N2.
Synonyms:exact_synonym: 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
 related_synonym: (+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole;   Formula=C13H16N2;   InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1;   InChIKey=CUHVIMMYOGQXCV-NSHDSACASA-N;   MPV 1440;   SMILES=C[C@H](c1c[nH]cn1)c1cccc(C)c1C;   dexmedetomidina;   dexmedetomidinum
 xref: Beilstein:5906875 "Beilstein";   CAS:113775-47-6 "ChemIDplus";   CAS:113775-47-6 "KEGG COMPOUND";   DrugBank:DB00633;   Drug_Central:835 "DrugCentral";   KEGG:C07450;   KEGG:D00514
 xref_mesh: MESH:D020927
 xref: Patent:GB2206880;   Patent:US4910214;   Wikipedia:Dexmedetomidine
 cyclic_relationship: is_enantiomer_of CHEBI:48555


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dexmedetomidine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra2a adrenoceptor alpha 2A JBrowse link 1 274,766,283 274,769,083 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mir381 microRNA 381 JBrowse link 6 133,876,615 133,876,675 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      biological role 19596
        pharmacological role 18671
          analgesic 13041
            dexmedetomidine 25
              dexmedetomidine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic molecule 19327
                              organic cyclic compound 19076
                                organic heterocyclic compound 18151
                                  heteroarene 15151
                                    monocyclic heteroarene 11614
                                      azole 10473
                                        diazole 8041
                                          imidazoles 7591
                                            medetomidine 26
                                              dexmedetomidine 25
                                                dexmedetomidine hydrochloride 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.