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Term:okadaic acid
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Accession:CHEBI:44658 term browser browse the term
Definition:A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
Synonyms:exact_synonym: (2R)-2-hydroxy-3-{(2S,5R,6R,8S)-5-hydroxy-8-[(2R,3E)-4-((2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl}-7'-methylideneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl)but-3-en-2-yl]-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl}-2-methylpropanoic acid
 related_synonym: 9,10-Deepithio-9,10-didehydroacanthifolicin;   Formula=C44H68O13;   InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1;   InChIKey=QNDVLZJODHBUFM-WFXQOWMNSA-N;   SMILES=[H][C@]1(CC[C@@H](O)[C@]2(O1)O[C@@]([H])(CC(C)=C2)[C@H](C)\\C=C\\[C@@]1([H])CC[C@@]2(CC[C@@]3([H])O[C@]([H])([C@@H](O)C[C@H](C)[C@@]4([H])O[C@@]5(CCCCO5)CC[C@H]4C)C(=C)[C@@H](O)[C@]3([H])O2)O1)C[C@@](C)(O)C(O)=O
 alt_id: CHEBI:44655;   CHEBI:7733
 xref: Beilstein:4640246 "Beilstein";   Beilstein:4900372 "Beilstein";   Beilstein:5471989 "Beilstein";   CAS:78111-17-8 "ChemIDplus";   CAS:78111-17-8 "KEGG COMPOUND";   DrugBank:DB02169;   KEGG:C01945
 xref_mesh: MESH:D019319
 xref: PDBeChem:OKA;   PMID:28429183 "Europe PMC";   PMID:28476539 "Europe PMC";   PMID:28648727 "Europe PMC";   PMID:28755633 "Europe PMC";   PMID:28817087 "Europe PMC";   Reaxys:4640246 "Reaxys"

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okadaic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB1 ATP binding cassette subfamily B member 1 JBrowse link 14 13,644,891 13,852,829 RGD:6480464

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 225
    role 225
      biological role 225
        biochemical role 187
          metabolite 179
            marine metabolite 38
              okadaic acid 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 225
    subatomic particle 225
      composite particle 225
        hadron 225
          baryon 225
            nucleon 225
              atomic nucleus 225
                atom 225
                  main group element atom 218
                    p-block element atom 218
                      carbon group element atom 206
                        carbon atom 205
                          organic molecular entity 205
                            heteroorganic entity 199
                              organochalcogen compound 167
                                organooxygen compound 166
                                  ether 58
                                    cyclic ether 5
                                      polycyclic ether 1
                                        okadaic acid 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.