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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:afimoxifene
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Accession:CHEBI:44616 term browser browse the term
Definition:A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Synonyms:related_synonym: 4-HYDROXYTAMOXIFEN;   4-OHT;   4-monohydroxytamoxifen;   Formula=C26H29NO2;   InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-;   InChIKey=TXUZVZSFRXZGTL-QPLCGJKRSA-N;   SMILES=CC\\C(c1ccccc1)=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1
 xref: CAS:68047-06-3;   CAS:68392-35-8;   KEGG:C05011;   KEGG:D06551
 xref_mesh: MESH:C016601
 xref: PDBeChem:OHT;   PMID:15159443;   PMID:16120301;   PMID:17351746;   PMID:20006599;   PMID:22388692;   PMID:26354796;   PMID:27882656;   PMID:30937657;   PMID:31195002;   PMID:31278729;   PMID:31519767;   PMID:32103133;   PMID:32175001;   Reaxys:4910748;   Wikipedia:Afimoxifene


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afimoxifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase decreases expression ISO afimoxifene results in decreased expression of ABAT mRNA CTD PMID:16849584 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO afimoxifene results in increased expression of ABCC3 mRNA CTD PMID:15072547 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
increases expression
ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ABCC5 mRNA]
afimoxifene results in increased expression of ABCC5 mRNA
CTD PMID:15072547, PMID:21233418 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ABCG1 mRNA] CTD PMID:21233418 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Abhd17c abhydrolase domain containing 17C, depalmitoylase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ABHD17C mRNA] CTD PMID:21233418 NCBI chr 1:146,248,505...146,289,465
Ensembl chr 1:146,248,503...146,289,465
JBrowse link
G Ackr3 atypical chemokine receptor 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ACKR3 mRNA] CTD PMID:21233418 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445
JBrowse link
G Ada adenosine deaminase decreases expression ISO afimoxifene results in decreased expression of ADA mRNA CTD PMID:19901195 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Adcy9 adenylate cyclase 9 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of ADCY9 mRNA] CTD PMID:21233418 NCBI chr10:11,392,698...11,515,406
Ensembl chr10:11,392,625...11,512,600
JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 increases expression ISO afimoxifene results in increased expression of ADGRG1 mRNA CTD PMID:16849584 NCBI chr19:10,423,534...10,460,674
Ensembl chr19:10,423,501...10,460,674
JBrowse link
G Ahnak AHNAK nucleoprotein decreases expression ISO afimoxifene results in decreased expression of AHNAK mRNA CTD PMID:16514628 NCBI chr 1:225,184,883...225,429,638
Ensembl chr 1:225,184,939...225,215,015
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions
ISO afimoxifene results in increased activity of AHR protein
afimoxifene promotes the reaction [AHR protein binds to ARNT protein]; afimoxifene promotes the reaction [AHR protein binds to CYP1A1 promoter]
CTD PMID:19901195 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO afimoxifene results in increased expression of AHRR mRNA CTD PMID:19901195 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Ak2 adenylate kinase 2 decreases response to substance ISO AK2 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 5:147,185,474...147,204,050
Ensembl chr 5:147,185,474...147,204,050
JBrowse link
G Ak5 adenylate kinase 5 decreases response to substance ISO AK5 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 2:257,671,772...257,864,385
Ensembl chr 2:257,671,772...257,864,385
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
decreases response to substance
ISO afimoxifene results in increased phosphorylation of AKT1 protein
AKT1 protein results in decreased susceptibility to afimoxifene
CTD PMID:18351453, PMID:19549922 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases response to substance ISO AKT2 protein results in decreased susceptibility to afimoxifene CTD PMID:18351453 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ALAD mRNA] CTD PMID:21233418 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of ALOX5 mRNA CTD PMID:25833159 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of AMD1 mRNA] CTD PMID:21233418 NCBI chr20:45,384,000...45,399,694
Ensembl chr20:45,384,000...45,399,694
JBrowse link
G Ank3 ankyrin 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ANK3 mRNA] CTD PMID:21233418 NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623
JBrowse link
G Apod apolipoprotein D increases expression ISO afimoxifene results in increased expression of APOD mRNA CTD PMID:16514628 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G Ar androgen receptor decreases activity ISO afimoxifene results in decreased activity of AR protein CTD PMID:9846162 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Areg amphiregulin decreases expression
increases expression
ISO afimoxifene results in decreased expression of AREG mRNA
afimoxifene results in increased expression of AREG mRNA
CTD PMID:15072547, PMID:16514628 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arid5a AT-rich interaction domain 5A multiple interactions ISO ARID5A protein inhibits the reaction [afimoxifene results in increased activity of ESR1 protein] CTD PMID:15941852 NCBI chr 9:42,871,907...42,886,725
Ensembl chr 9:42,871,950...42,884,855
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO afimoxifene promotes the reaction [AHR protein binds to ARNT protein] CTD PMID:19901195 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 increases expression ISO afimoxifene results in increased expression of ARNT2 mRNA CTD PMID:16514628 NCBI chr 1:146,399,217...146,556,437
Ensembl chr 1:146,399,217...146,556,171
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression
increases expression
ISO afimoxifene results in decreased expression of ASCL1 mRNA
afimoxifene results in increased expression of ASCL1 mRNA
CTD PMID:16849584, PMID:19901195 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO afimoxifene results in decreased expression of ASNS mRNA CTD PMID:16514628 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atf3 activating transcription factor 3 increases expression
multiple interactions
ISO afimoxifene results in increased expression of ATF3 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of ATF3 mRNA]
CTD PMID:19153601 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atp8b2 ATPase phospholipid transporting 8B2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ATP8B2 mRNA] CTD PMID:21233418 NCBI chr 2:189,285,961...189,306,947
Ensembl chr 2:189,285,953...189,307,108
JBrowse link
G Atr ATR serine/threonine kinase decreases response to substance ISO ATR results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Aurka aurora kinase A decreases expression
decreases response to substance
ISO afimoxifene results in decreased expression of AURKA mRNA
AURKA results in decreased susceptibility to afimoxifene
CTD PMID:16514628, PMID:21233418 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 increases expression ISO afimoxifene results in increased expression of B3GNT2 mRNA CTD PMID:16849584 NCBI chr14:107,592,336...107,617,189
Ensembl chr14:107,592,336...107,617,161
JBrowse link
G Bap1 Brca1 associated protein 1 affects response to substance ISO BAP1 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr16:7,336,685...7,345,511
Ensembl chr16:7,336,685...7,345,511
JBrowse link
G Bbs5 Bardet-Biedl syndrome 5 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of BBS5 mRNA] CTD PMID:21233418 NCBI chr 3:55,886,695...55,907,717
Ensembl chr 3:55,886,695...55,907,716
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases response to substance ISO BCAR1 protein results in decreased susceptibility to afimoxifene CTD PMID:18351453 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO afimoxifene results in decreased expression of BCL2 mRNA
[annonacin co-treated with afimoxifene] results in decreased expression of BCL2 protein
CTD PMID:19698761, PMID:21840388 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO afimoxifene results in increased expression of BCL2L1 mRNA CTD PMID:19698761 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl3 BCL3, transcription coactivator multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of BCL3 mRNA] CTD PMID:21233418 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Bcl9l BCL9 like multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of BCL9L mRNA] CTD PMID:21233418 NCBI chr 8:48,805,684...48,835,794
Ensembl chr 8:48,805,684...48,834,312
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of BDKRB2 mRNA CTD PMID:25833159 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression
multiple interactions
ISO afimoxifene results in increased expression of BHLHE40 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of BHLHE40 mRNA]
CTD PMID:16849584, PMID:19153601 NCBI chr 4:140,703,619...140,709,319
Ensembl chr 4:140,703,619...140,709,319
JBrowse link
G Bik BCL2-interacting killer increases expression ISO afimoxifene results in increased expression of BIK mRNA CTD PMID:23373633 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase decreases response to substance ISO BLK results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr15:46,555,552...46,593,778
Ensembl chr15:46,555,188...46,593,653
JBrowse link
G Blnk B-cell linker multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of BLNK mRNA] CTD PMID:21233418 NCBI chr 1:260,187,023...260,254,490
Ensembl chr 1:260,186,967...260,254,600
JBrowse link
G Blvrb biliverdin reductase B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of BLVRB mRNA] CTD PMID:21233418 NCBI chr 1:84,256,063...84,273,726
Ensembl chr 1:84,256,159...84,274,075
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of BMP7 mRNA] CTD PMID:21233418 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399
JBrowse link
G Bod1 biorientation of chromosomes in cell division 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of BOD1 mRNA] CTD PMID:21233418 NCBI chr10:16,259,728...16,266,069
Ensembl chr10:16,259,728...16,266,061
JBrowse link
G Bop1 BOP1 ribosomal biogenesis factor multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of BOP1 mRNA] CTD PMID:21233418 NCBI chr 7:117,514,529...117,538,342
Ensembl chr 7:117,514,533...117,538,342
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions ISO [BRAF protein co-treated with afimoxifene] results in increased expression of and results in increased activity of EGR1 protein; [BRAF protein co-treated with afimoxifene] results in increased phosphorylation of MAPK1 protein; [BRAF protein co-treated with afimoxifene] results in increased phosphorylation of MAPK3 protein CTD PMID:25645941 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Brd2 bromodomain containing 2 decreases response to substance ISO BRD2 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr20:3,910,555...3,921,074
Ensembl chr20:3,910,555...3,917,426
Ensembl chr20:3,910,555...3,917,426
JBrowse link
G Btg1 BTG anti-proliferation factor 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of BTG1 mRNA] CTD PMID:21233418 NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088
JBrowse link
G C3 complement C3 increases expression ISO afimoxifene results in increased expression of C3 protein CTD PMID:11390168 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Ca12 carbonic anhydrase 12 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CA12 mRNA] CTD PMID:21233418 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240
JBrowse link
G Calcr calcitonin receptor increases expression ISO afimoxifene results in increased expression of CALCR mRNA CTD PMID:19901195 NCBI chr 4:28,627,439...28,702,559
Ensembl chr 4:28,627,442...28,702,559
JBrowse link
G Calm3 calmodulin 3 decreases response to substance ISO CALM3 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 1:78,844,520...78,851,628
Ensembl chr 1:78,843,080...78,851,719
JBrowse link
G Camk1 calcium/calmodulin-dependent protein kinase I decreases response to substance ISO CAMK1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 4:145,289,300...145,300,146
Ensembl chr 4:145,288,996...145,300,177
JBrowse link
G Cap2 cyclase associated actin cytoskeleton regulatory protein 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CAP2 mRNA] CTD PMID:21233418 NCBI chr17:18,441,614...18,592,866
Ensembl chr17:18,442,127...18,592,750
JBrowse link
G Car2 carbonic anhydrase 2 increases expression ISO afimoxifene results in increased expression of CA2 mRNA CTD PMID:19698761 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Card6 caspase recruitment domain family, member 6 increases expression ISO afimoxifene results in increased expression of CARD6 mRNA CTD PMID:23373633 NCBI chr 2:54,810,676...54,824,050
Ensembl chr 2:54,810,110...54,824,033
JBrowse link
G Cbx1 chromobox 1 decreases expression ISO afimoxifene results in decreased expression of CBX1 mRNA CTD PMID:16514628 NCBI chr10:84,656,698...84,677,112
Ensembl chr10:84,669,914...84,675,741
JBrowse link
G Ccdc88c coiled-coil domain containing 88C multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CCDC88C mRNA] CTD PMID:21233418 NCBI chr 6:124,905,811...125,028,011
Ensembl chr 6:124,905,808...125,027,553
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of CCN1 mRNA] CTD PMID:19153601 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
affects response to substance
multiple interactions
ISO afimoxifene results in increased expression of CCN2 mRNA; afimoxifene results in increased expression of CCN2 protein
CCN2 protein affects the susceptibility to afimoxifene
GPER1 protein affects the reaction [afimoxifene results in increased expression of CCN2 mRNA]
CTD PMID:19153601 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccn3 cellular communication network factor 3 decreases expression ISO afimoxifene results in decreased expression of CCN3 mRNA CTD PMID:15072547 NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024
JBrowse link
G Ccna1 cyclin A1 increases expression ISO afimoxifene results in increased expression of CCNA1 mRNA CTD PMID:12154049 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
JBrowse link
G Ccna2 cyclin A2 increases expression ISO afimoxifene results in increased expression of CCNA2 mRNA CTD PMID:15072547 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd1 cyclin D1 decreases expression
increases expression
multiple interactions
ISO afimoxifene results in decreased expression of CCND1 protein
afimoxifene results in increased expression of CCND1 mRNA
[afimoxifene co-treated with lapatinib] results in decreased expression of CCND1 protein; afimoxifene inhibits the reaction [Estrogens results in increased expression of CCND1 mRNA]
CTD PMID:15665275, PMID:17640349, PMID:21233418 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 multiple interactions
increases cleavage
ISO [afimoxifene co-treated with lapatinib] promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; afimoxifene promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; GPER1 protein affects the reaction [afimoxifene results in increased cleavage of CCNE1 protein]; U 0126 inhibits the reaction [afimoxifene results in increased cleavage of CCNE1 protein] CTD PMID:15665275, PMID:23624423 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO afimoxifene results in decreased expression of CCNE2 mRNA CTD PMID:19698761 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CCNG2 mRNA] CTD PMID:21233418 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cd24 CD24 molecule increases expression ISO afimoxifene results in increased expression of CD24 mRNA CTD PMID:16514628 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Cd36 CD36 molecule multiple interactions
decreases expression
ISO PPARG mRNA promotes the reaction [afimoxifene results in decreased expression of CD36 protein]
afimoxifene results in decreased expression of CD36 mRNA; afimoxifene results in decreased expression of CD36 protein
afimoxifene inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of CD36 protein]; afimoxifene inhibits the reaction [PPARG protein binds to CD36 promoter]; afimoxifene inhibits the reaction [PPARG protein results in increased expression of CD36 mRNA]; afimoxifene inhibits the reaction [Rosiglitazone results in increased expression of CD36 mRNA]; afimoxifene inhibits the reaction [Rosiglitazone results in increased expression of CD36 protein]; afimoxifene inhibits the reaction [Troglitazone results in increased expression of CD36 protein]; afimoxifene inhibits the reaction [U 0126 results in increased expression of CD36 protein]
CTD PMID:27358406 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd40 CD40 molecule multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of CD40 mRNA CTD PMID:25833159 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO afimoxifene results in increased expression of CD44 mRNA CTD PMID:16849584 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CDC6 mRNA] CTD PMID:21233418 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdca7 cell division cycle associated 7 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CDCA7 mRNA] CTD PMID:21233418 NCBI chr 3:59,153,281...59,163,916
Ensembl chr 3:59,153,280...59,163,913
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]; [afimoxifene co-treated with EGF protein] results in increased expression of CDH1 mRNA; [afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein; afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]; AG 1879 inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; AG 1879 inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]; Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]]
afimoxifene results in increased expression of CDH1 mRNA; afimoxifene results in increased expression of CDH1 protein
CTD PMID:19593637 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh11 cadherin 11 decreases expression ISO afimoxifene results in decreased expression of CDH11 mRNA CTD PMID:19901195 NCBI chr19:2,391,181...2,551,245
Ensembl chr19:2,393,059...2,551,245
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases response to substance
increases expression
ISO CDK1 results in decreased susceptibility to afimoxifene
afimoxifene results in increased expression of CDK1 mRNA
CTD PMID:19901195, PMID:21233418 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk18 cyclin-dependent kinase 18 increases expression ISO afimoxifene results in increased expression of CDK18 mRNA CTD PMID:16849584 NCBI chr13:48,893,525...48,926,673
Ensembl chr13:48,893,412...48,927,483
JBrowse link
G Cdk19 cyclin-dependent kinase 19 increases expression ISO afimoxifene results in increased expression of CDK19 mRNA CTD PMID:16849584 NCBI chr20:45,458,499...45,598,799
Ensembl chr20:45,458,558...45,598,798
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [afimoxifene co-treated with lapatinib] promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; afimoxifene promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]] CTD PMID:15665275 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk9 cyclin-dependent kinase 9 decreases response to substance ISO CDK9 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 3:11,742,269...11,747,117
Ensembl chr 3:11,742,266...11,747,113
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CDKN1A mRNA]
afimoxifene results in increased expression of CDKN1A mRNA
CTD PMID:12154049, PMID:21233418 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO [afimoxifene co-treated with lapatinib] promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; [afimoxifene co-treated with lapatinib] results in increased expression of CDKN1B protein; afimoxifene promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]
afimoxifene results in increased expression of CDKN1B protein
afimoxifene results in increased expression of CDKN1B mRNA
CTD PMID:15665275, PMID:17640349 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CDKN2B mRNA] CTD PMID:21233418 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CDT1 mRNA] CTD PMID:21233418 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression
multiple interactions
ISO afimoxifene results in increased expression of CEBPD mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of CEBPD mRNA]
CTD PMID:19153601 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Cenpa centromere protein A decreases expression ISO afimoxifene results in decreased expression of CENPA mRNA CTD PMID:16514628 NCBI chr 6:27,072,259...27,080,863
Ensembl chr 6:27,072,166...27,080,856
JBrowse link
G Cgn cingulin multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CGN mRNA] CTD PMID:21233418 NCBI chr 2:195,909,691...195,937,130
Ensembl chr 2:195,909,626...195,935,878
JBrowse link
G Cish cytokine inducible SH2-containing protein multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CISH mRNA] CTD PMID:21233418 NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723
JBrowse link
G Ckb creatine kinase B decreases response to substance ISO CKB results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 decreases response to substance ISO CKMT1B results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 3:113,318,559...113,324,459
Ensembl chr 3:113,318,563...113,324,461
JBrowse link
G Clic3 chloride intracellular channel 3 increases expression ISO afimoxifene results in increased expression of CLIC3 mRNA CTD PMID:16849584 NCBI chr 3:2,675,732...2,678,248
Ensembl chr 3:2,676,296...2,680,565
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CLIP1 mRNA] CTD PMID:21233418 NCBI chr12:38,345,203...38,452,650
Ensembl chr12:38,345,456...38,452,652
JBrowse link
G Clk4 CDC-like kinase 4 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CLK4 mRNA] CTD PMID:21233418 NCBI chr10:36,715,565...36,733,473
Ensembl chr10:36,715,565...36,733,133
JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit affects response to substance ISO CLPP gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 9:10,048,715...10,056,068
Ensembl chr 9:10,048,886...10,054,359
JBrowse link
G Clstn1 calsyntenin 1 decreases expression ISO afimoxifene results in decreased expression of CLSTN1 mRNA CTD PMID:16514628 NCBI chr 5:166,533,262...166,601,686
Ensembl chr 5:166,533,181...166,601,684
JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein increases expression ISO afimoxifene results in increased expression of CNBP mRNA CTD PMID:12154049 NCBI chr 4:119,747,890...119,756,787
Ensembl chr 4:119,747,911...119,756,765
JBrowse link
G Col4a3 collagen type IV alpha 3 chain decreases expression ISO afimoxifene results in decreased expression of COL4A3 mRNA CTD PMID:23373633 NCBI chr 9:88,357,528...88,484,735
Ensembl chr 9:88,357,556...88,485,830
JBrowse link
G Col4a6 collagen type IV alpha 6 chain decreases expression ISO afimoxifene results in decreased expression of COL4A6 mRNA CTD PMID:19901195 NCBI chr  X:112,405,647...112,768,337
Ensembl chr  X:112,405,647...112,473,822
JBrowse link
G Copb2 COPI coat complex subunit beta 2 decreases expression ISO afimoxifene results in decreased expression of COPB2 mRNA CTD PMID:16514628 NCBI chr 8:106,582,339...106,603,763 JBrowse link
G Cpm carboxypeptidase M increases expression ISO afimoxifene results in increased expression of CPM mRNA CTD PMID:16849584 NCBI chr 7:60,654,350...60,714,620
Ensembl chr 7:60,654,350...60,714,620
JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CRIM1 mRNA] CTD PMID:21233418 NCBI chr 6:788,490...962,663
Ensembl chr 6:788,548...960,703
JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of AXUD1 mRNA] CTD PMID:21233418 NCBI chr 8:128,659,883...128,673,339
Ensembl chr 8:128,659,868...128,672,284
JBrowse link
G Csta cystatin A decreases expression ISO afimoxifene results in decreased expression of CSTA mRNA CTD PMID:15072547 NCBI chr11:67,555,792...67,566,980
Ensembl chr11:67,555,658...67,566,972
JBrowse link
G Ctdsp1 CTD small phosphatase 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CTDSP1 mRNA] CTD PMID:21233418 NCBI chr 9:81,672,613...81,677,979
Ensembl chr 9:81,672,758...81,677,979
JBrowse link
G Ctsd cathepsin D increases expression ISO afimoxifene results in increased expression of CTSD mRNA CTD PMID:15072547 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Ctsh cathepsin H increases expression ISO afimoxifene results in increased expression of CTSH mRNA CTD PMID:16514628 NCBI chr 8:97,439,155...97,458,293
Ensembl chr 8:97,439,161...97,458,287
JBrowse link
G Cuedc1 CUE domain containing 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CUEDC1 mRNA] CTD PMID:21233418 NCBI chr10:75,495,817...75,516,280
Ensembl chr10:75,495,817...75,516,304
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO afimoxifene inhibits the reaction [Estradiol results in increased secretion of CXCL12 protein]; afimoxifene inhibits the reaction [Estrogens results in increased expression of CXCL12 mRNA] CTD PMID:20549624, PMID:21233418 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression
multiple interactions
increases metabolic processing
ISO afimoxifene results in increased expression of CYP19A1 mRNA
[CYP19A1 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite
CTD PMID:19549922, PMID:29285606 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases metabolic processing
increases expression
ISO 3'-methoxy-4'-nitroflavone inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA]; [CYP1A1 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite; afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]]; afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; afimoxifene promotes the reaction [AHR protein binds to CYP1A1 promoter]; alpha-naphthoflavone inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA] CTD PMID:18493746, PMID:19460354, PMID:19901195, PMID:29285606 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
ISO CYP1A2 protein results in increased metabolism of afimoxifene
[CYP1A2 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite
CTD PMID:29285606 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
decreases activity
ISO afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]
afimoxifene results in increased expression of CYP1B1 mRNA
afimoxifene results in decreased activity of CYP1B1 protein
CTD PMID:12419016, PMID:19460354, PMID:19901195 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases metabolic processing
ISO [CYP2B6 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite CTD PMID:29285606 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of afimoxifene CTD PMID:29285606 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
decreases activity
ISO CYP2C8 protein results in increased metabolism of afimoxifene
afimoxifene results in decreased activity of CYP2C8 protein
CTD PMID:29285606 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases metabolic processing
ISO [CYP2D6 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite CTD PMID:29285606 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases activity
increases metabolic processing
multiple interactions
ISO afimoxifene results in decreased activity of CYP3A5 protein
CYP3A5 protein results in increased metabolism of afimoxifene
[CYP3A5 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite
CTD PMID:12419016, PMID:29285606 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp4f39 cytochrome P450, family 4, subfamily f, polypeptide 39 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CYP4F22 mRNA] CTD PMID:21233418 NCBI chr 7:14,435,024...14,514,960
Ensembl chr 7:14,441,476...14,515,212
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of DDIT3 mRNA] CTD PMID:19153601 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression
multiple interactions
ISO afimoxifene results in increased expression of DDIT4 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of DDIT4 mRNA]
CTD PMID:19153601 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ddx10 DEAD-box helicase 10 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of DDX10 mRNA] CTD PMID:21233418 NCBI chr 8:57,667,472...57,830,504
Ensembl chr 8:57,667,472...57,830,504
JBrowse link
G Ddx21 DExD-box helicase 21 multiple interactions
decreases expression
ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of DDX21 mRNA]
afimoxifene results in decreased expression of DDX21 mRNA
CTD PMID:16514628, PMID:21233418 NCBI chr20:32,213,147...32,232,632
Ensembl chr20:32,213,148...32,232,632
JBrowse link
G Ddx27 DEAD-box helicase 27 decreases expression ISO afimoxifene results in decreased expression of DDX27 mRNA CTD PMID:19698761 NCBI chr 3:163,767,236...163,786,408
Ensembl chr 3:163,767,173...163,786,445
JBrowse link
G Dhx33 DEAH-box helicase 33 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of DHX33 mRNA] CTD PMID:21233418 NCBI chr10:57,622,022...57,638,485
Ensembl chr10:57,622,022...57,638,485
JBrowse link
G Dhx9 DExH-box helicase 9 decreases expression ISO afimoxifene results in decreased expression of DHX9 mRNA CTD PMID:16514628 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Dixdc1 DIX domain containing 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of DIXDC1 mRNA] CTD PMID:21233418 NCBI chr 8:55,091,232...55,164,636
Ensembl chr 8:55,091,235...55,162,421
JBrowse link
G Dkc1 dyskerin pseudouridine synthase 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of DKC1 mRNA] CTD PMID:21233418 NCBI chr  X:155,844,914...155,862,363
Ensembl chr  X:155,844,857...155,862,475
JBrowse link
G Dnah2 dynein, axonemal, heavy chain 2 decreases response to substance ISO DNAH2 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:56,029,022...56,154,602
Ensembl chr10:56,029,029...56,154,548
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 decreases expression ISO afimoxifene results in decreased expression of DNAJA1 mRNA CTD PMID:16514628 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 decreases expression ISO afimoxifene results in decreased expression of DNAJC12 mRNA CTD PMID:16849584 NCBI chr20:26,893,139...26,913,041
Ensembl chr20:26,893,016...26,913,016
JBrowse link
G Drd1 dopamine receptor D1 increases expression ISO afimoxifene results in increased expression of DRD1 mRNA CTD PMID:19901195 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP1 mRNA] CTD PMID:19153601 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression
multiple interactions
ISO afimoxifene results in increased expression of DUSP4 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP4 mRNA]
CTD PMID:19153601 NCBI chr16:61,080,767...61,090,973
Ensembl chr16:61,078,175...61,091,169
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression
multiple interactions
ISO afimoxifene results in increased expression of DUSP5 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP5 mRNA]
CTD PMID:19153601 NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595
JBrowse link
G Dynll1 dynein light chain LC8-type 1 increases expression ISO afimoxifene results in increased expression of DYNLL1 mRNA CTD PMID:12154049 NCBI chr12:47,074,200...47,076,573
Ensembl chr12:47,074,200...47,076,572
JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of E2F4 mRNA] CTD PMID:21233418 NCBI chr19:37,252,828...37,260,239
Ensembl chr19:37,252,843...37,260,239
JBrowse link
G Ece2 endothelin-converting enzyme 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of ECE2 mRNA] CTD PMID:21233418 NCBI chr11:83,948,896...83,985,429
Ensembl chr11:83,948,230...83,964,055
JBrowse link
G Edf1 endothelial differentiation-related factor 1 affects response to substance ISO EDF1 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 3:2,781,169...2,785,474
Ensembl chr 3:2,781,169...2,785,474
JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions
ISO afimoxifene results in increased expression of EDN1 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of EDN1 mRNA]
CTD PMID:19153601 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn2 endothelin 2 increases expression
multiple interactions
ISO afimoxifene results in increased expression of EDN2 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of EDN2 mRNA]
CTD PMID:19153601 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
JBrowse link
G Efna1 ephrin A1 multiple interactions
decreases expression
ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of EFNA1 mRNA]
afimoxifene results in decreased expression of EFNA1 mRNA
CTD PMID:15072547, PMID:21233418 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Efnb2 ephrin B2 increases expression ISO afimoxifene results in increased expression of EFNB2 mRNA CTD PMID:16849584 NCBI chr16:86,631,151...86,672,050
Ensembl chr16:86,631,064...86,675,049
JBrowse link
G Egf epidermal growth factor multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; [afimoxifene co-treated with EGF protein] results in increased expression of CDH1 mRNA; [afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein; AG 1879 inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein] CTD PMID:19593637 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor decreases response to substance ISO EGFR protein results in decreased susceptibility to afimoxifene; EGFR results in decreased susceptibility to afimoxifene CTD PMID:18351453, PMID:21233418 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO [BRAF protein co-treated with afimoxifene] results in increased expression of and results in increased activity of EGR1 protein; GPER1 protein affects the reaction [afimoxifene results in increased expression of EGR1 mRNA] CTD PMID:19153601, PMID:25645941 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr3 early growth response 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of EGR3 mRNA] CTD PMID:21233418 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha decreases expression ISO afimoxifene results in decreased expression of EIF2S1 mRNA CTD PMID:16514628 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 decreases expression ISO afimoxifene results in decreased expression of EIF5 mRNA CTD PMID:16514628 NCBI chr 6:136,002,983...136,011,409
Ensembl chr 6:136,004,214...136,011,406
JBrowse link
G Elf3 E74 like ETS transcription factor 3 increases expression ISO afimoxifene results in increased expression of ELF3 mRNA CTD PMID:16849584 NCBI chr13:52,083,873...52,088,798
Ensembl chr13:52,083,859...52,088,780
JBrowse link
G Elob elongin B decreases expression ISO afimoxifene results in decreased expression of ELOB mRNA CTD PMID:16514628 NCBI chr10:13,163,032...13,168,217
Ensembl chr10:13,163,036...13,168,217
JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of ELOVL2 mRNA] CTD PMID:21233418 NCBI chr17:21,382,461...21,422,413
Ensembl chr17:21,382,455...21,422,407
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 decreases expression ISO afimoxifene results in decreased expression of ELOVL5 mRNA CTD PMID:16514628 NCBI chr 8:85,220,941...85,287,449
Ensembl chr 8:85,259,982...85,285,983
JBrowse link
G Enc1 ectodermal-neural cortex 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ENC1 mRNA] CTD PMID:21233418 NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029
JBrowse link
G Eno1 enolase 1 decreases response to substance ISO ENO1 mRNA results in decreased susceptibility to afimoxifene CTD PMID:19655245 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Epb41l4a erythrocyte membrane protein band 4.1 like 4A multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of EPB41L4A mRNA] CTD PMID:21233418 NCBI chr18:26,570,051...26,788,586
Ensembl chr18:26,570,647...26,658,892
JBrowse link
G Epha1 Eph receptor A1 increases expression ISO afimoxifene results in increased expression of EPHA1 mRNA CTD PMID:12154049 NCBI chr 4:71,749,100...71,763,681
Ensembl chr 4:71,749,242...71,763,679
JBrowse link
G Eps8 epidermal growth factor receptor pathway substrate 8 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of EPS8 mRNA] CTD PMID:21233418 NCBI chr 4:171,475,155...171,645,620
Ensembl chr 4:171,475,567...171,591,882
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases expression
decreases expression
decreases response to substance
multiple interactions
ISO afimoxifene results in increased expression of ERBB2 mRNA
afimoxifene results in decreased expression of ERBB2 mRNA
ERBB2 results in decreased susceptibility to afimoxifene
afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; afimoxifene inhibits the reaction [Estrogens results in decreased expression of ERBB2 mRNA]
CTD PMID:12439862, PMID:15072547, PMID:17640349, PMID:21233418 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions ISO afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]] CTD PMID:12439862 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of ERRFI1 mRNA] CTD PMID:19153601 NCBI chr 5:167,951,564...167,966,011
Ensembl chr 5:167,952,728...167,966,009
JBrowse link
G Esr1 estrogen receptor 1 increases expression
affects binding
affects folding
decreases activity
multiple interactions
ISO afimoxifene results in increased expression of ESR1 protein
[afimoxifene binds to ESR1 protein] which binds to TFF1 protein; afimoxifene binds to ESR1 protein
afimoxifene affects the folding of ESR1 protein
afimoxifene results in decreased activity of ESR1 protein
4-hydroxy-N-desmethyltamoxifen inhibits the reaction [[Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 protein]; [afimoxifene binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Equol; [afimoxifene binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Genistein; [afimoxifene results in decreased susceptibility to Estradiol] which results in decreased expression of ESR1 protein modified form; [afimoxifene results in decreased susceptibility to glyphosate] which results in increased expression of ESR1 protein modified form; [annonacin co-treated with afimoxifene] results in decreased activity of ESR1 protein; [Lapatinib co-treated with afimoxifene] results in decreased activity of ESR1 protein; [methylselenic acid co-treated with afimoxifene] results in decreased expression of ESR1 mRNA; [methylselenic acid co-treated with afimoxifene] results in decreased expression of ESR1 protein; [Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 protein; afimoxifene binds to and affects the activity of ESR1 protein; afimoxifene binds to and affects the folding of ESR1 protein; afimoxifene binds to and affects the folding of ESR1 protein mutant form; afimoxifene binds to and results in decreased activity of ESR1 protein; afimoxifene binds to and results in increased activity of ESR1 protein; afimoxifene inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; afimoxifene inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; afimoxifene inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; afimoxifene inhibits the reaction [[Chlorpyrifos co-treated with Estradiol] results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein]; afimoxifene inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [bisphenol A results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [ESR1 protein binds to STUB1 protein]; afimoxifene inhibits the reaction [Estradiol binds to ESR1 protein]; afimoxifene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; afimoxifene inhibits the reaction [fenarimol results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [glyphosate results in increased expression of ESR1 protein]; afimoxifene inhibits the reaction [nonylphenol results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]]; afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]; afimoxifene promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]; afimoxifene promotes the reaction [ESR1 protein binds to TFF1 promoter]; afimoxifene results in increased activity of and affects the localization of ESR1 protein; ARID5A protein inhibits the reaction [afimoxifene results in increased activity of ESR1 protein]; ESR1 protein promotes the reaction [afimoxifene results in increased expression of SERPINB9 mRNA]; Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]]
afimoxifene binds to and affects the folding of ESR1 protein mutant form; ESR1 protein promotes the reaction [afimoxifene results in increased phosphorylation of and results in increased activity of IGF1R protein]
CTD PMID:9048584, PMID:9751507, PMID:9846162, PMID:10397250, PMID:10614829, PMID:10965916, PMID:11162928, PMID:11518614, PMID:11530281, PMID:11751013, PMID:12765246, PMID:14617632, PMID:14709801, PMID:14754635, PMID:15081572, PMID:15161930, PMID:15521089, PMID:15537743, PMID:15665275, PMID:15885261, PMID:15941852, PMID:16037132, PMID:16093440, PMID:17049190, PMID:17203231, PMID:17237823, PMID:17400923, PMID:18678925, PMID:18976723, PMID:19233257, PMID:19244106, PMID:19427779, PMID:19460354, PMID:19593637, PMID:19858209, PMID:19913605, PMID:20362049, PMID:20435135, PMID:21256200, PMID:21543282, PMID:21840388, PMID:22558281, PMID:25012808, PMID:26812056, PMID:27156127, PMID:27721470, PMID:28248286, PMID:29890199, PMID:30077407 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 affects expression
affects binding
multiple interactions
increases response to substance
ISO
EXP
afimoxifene affects the expression of ESR2 protein
afimoxifene binds to ESR2 protein
afimoxifene binds to and results in decreased activity of ESR2 protein; afimoxifene inhibits the reaction [Estradiol binds to ESR2 protein]; afimoxifene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; afimoxifene inhibits the reaction [methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of RAB30 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of SOCS1 mRNA]
afimoxifene inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; afimoxifene inhibits the reaction [Estradiol binds to ESR2 protein alternative form]
ESR2 protein results in increased susceptibility to afimoxifene
CTD PMID:9048584, PMID:9492041, PMID:9751507, PMID:15103026, PMID:15537743, PMID:15721411, PMID:15821116, PMID:16849584, PMID:17203231, PMID:19913605, PMID:28248286 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
affects binding
ISO afimoxifene binds to and results in decreased activity of [ESRRG protein binds to ESRRA protein]
afimoxifene binds to ESRRA protein mutant form
CTD PMID:11447273, PMID:14751226 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions
affects binding
decreases activity
ISO
EXP
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]; 4-isopropylphenol inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]; 5,6,7,8-tetrahydro-2-naphthol inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]; afimoxifene binds to and affects the activity of ESRRG protein; afimoxifene binds to and results in decreased activity of [ESRRG protein binds to ESRRA protein]; afimoxifene binds to and results in decreased activity of ESRRG protein; afimoxifene inhibits the reaction [ESRRG protein binds to NCOA1 protein]; afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]; afimoxifene inhibits the reaction [PPARGC1A protein binds to ESRRG protein]; benzylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; bisphenol A inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]; bisphenol A inhibits the reaction [afimoxifene binds to ESRRG protein]; bisphenol A inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; bisphenol A inhibits the reaction [afimoxifene results in decreased activity of ESRRG protein]; butylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; chlorocresol inhibits the reaction [afimoxifene binds to ESRRG protein]; ethyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; ethyl-p-hydroxybenzoate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; methylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; N'-((1E)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazide inhibits the reaction [afimoxifene results in decreased activity of ESRRG protein]; propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]
afimoxifene binds to and results in decreased activity of ESRRG protein; afimoxifene inhibits the reaction [bisphenol A binds to and results in increased activity of ESRRG protein]
CTD PMID:11447273, PMID:14751226, PMID:15149736, PMID:15161930, PMID:16889744, PMID:17049190, PMID:17964775, PMID:18197296, PMID:20542892, PMID:23583298, PMID:23645310, PMID:30951782, PMID:31127318 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
JBrowse link
G Etnk1 ethanolamine kinase 1 decreases response to substance
increases expression
ISO ETNK1 results in decreased susceptibility to afimoxifene
afimoxifene results in increased expression of ETNK1 mRNA
CTD PMID:16849584, PMID:21233418 NCBI chr 4:177,402,904...177,447,047
Ensembl chr 4:177,402,904...177,447,028
JBrowse link
G Exosc2 exosome component 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of EXOSC2 mRNA] CTD PMID:21233418 NCBI chr 3:10,151,734...10,161,997
Ensembl chr 3:10,151,284...10,161,989
JBrowse link
G Fa2h fatty acid 2-hydroxylase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FA2H mRNA] CTD PMID:21233418 NCBI chr19:43,545,380...43,596,788
Ensembl chr19:43,545,378...43,596,801
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 decreases expression ISO afimoxifene results in decreased expression of FAIM2 mRNA CTD PMID:23373633 NCBI chr 7:141,158,769...141,185,781
Ensembl chr 7:141,157,963...141,185,710
JBrowse link
G Fam102a family with sequence similarity 102, member A multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of FAM102A mRNA] CTD PMID:21233418 NCBI chr 3:11,554,084...11,586,315
Ensembl chr 3:11,554,457...11,586,303
JBrowse link
G Fam107b family with sequence similarity 107, member B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM107B mRNA] CTD PMID:21233418 NCBI chr17:78,489,667...78,689,933
Ensembl chr17:78,489,668...78,561,613
JBrowse link
G Fam110b family with sequence similarity 110, member B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM110B mRNA] CTD PMID:21233418 NCBI chr 5:18,762,488...18,903,818
Ensembl chr 5:18,901,039...18,902,672
JBrowse link
G Fam110c family with sequence similarity 110, member C multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM110C mRNA] CTD PMID:21233418 NCBI chr 6:49,968,473...49,974,730
Ensembl chr 6:49,968,473...49,974,728
JBrowse link
G Fam204a family with sequence similarity 204, member A multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM204A mRNA] CTD PMID:21233418 NCBI chr 1:281,343,692...281,403,699
Ensembl chr 1:281,347,536...281,376,834
JBrowse link
G Fam20c FAM20C, golgi associated secretory pathway kinase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM20C mRNA] CTD PMID:21233418 NCBI chr12:17,913,771...17,972,733
Ensembl chr12:17,913,767...17,972,737
JBrowse link
G Fam43a family with sequence similarity 43, member A multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM43A mRNA] CTD PMID:21233418 NCBI chr11:73,676,601...73,679,003
Ensembl chr11:73,676,601...73,678,984
JBrowse link
G Fam83b family with sequence similarity 83, member B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM83B mRNA] CTD PMID:21233418 NCBI chr 8:83,616,148...83,693,484
Ensembl chr 8:83,613,023...83,693,472
JBrowse link
G Farp1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 increases expression
multiple interactions
ISO afimoxifene results in increased expression of FARP1 mRNA
ESR2 protein inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]; Estradiol inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]
CTD PMID:16849584 NCBI chr15:106,375,298...106,625,837
Ensembl chr15:106,434,177...106,625,837
JBrowse link
G Fbxl18 F-box and leucine-rich repeat protein 18 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FBXL18 mRNA] CTD PMID:21233418 NCBI chr12:13,728,155...13,751,781
Ensembl chr12:13,734,429...13,747,215
JBrowse link
G Flna filamin A increases expression ISO afimoxifene results in increased expression of FLNA mRNA CTD PMID:19698761 NCBI chr  X:156,460,785...156,487,245
Ensembl chr  X:156,463,953...156,487,245
JBrowse link
G Flnc filamin C decreases expression ISO afimoxifene results in decreased expression of FLNC mRNA CTD PMID:16514628 NCBI chr 4:56,710,934...56,738,779
Ensembl chr 4:56,711,049...56,738,791
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases secretion ISO afimoxifene results in decreased secretion of FLT1 protein CTD PMID:19828145 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO afimoxifene results in decreased expression of FN1 mRNA CTD PMID:19901195 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [afimoxifene results in increased expression of FOS mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [afimoxifene results in increased expression of FOS protein]; GPER1 protein affects the reaction [afimoxifene results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [afimoxifene results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [afimoxifene results in increased expression of FOS protein]
afimoxifene results in increased expression of FOS mRNA; afimoxifene results in increased expression of FOS protein
CTD PMID:15072547, PMID:19153601, PMID:19901195, PMID:19935718 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of FOSB mRNA] CTD PMID:19153601 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Foxp4 forkhead box P4 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FOXP4 mRNA] CTD PMID:21233418 NCBI chr 9:15,068,378...15,124,962
Ensembl chr 9:15,068,399...15,125,318
JBrowse link
G Frat1 FRAT regulator of WNT signaling pathway 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FRAT1 mRNA] CTD PMID:21233418 NCBI chr 1:261,071,965...261,075,244 JBrowse link
G Frk fyn-related Src family tyrosine kinase increases expression
decreases response to substance
ISO afimoxifene results in increased expression of FRK mRNA
FRK results in decreased susceptibility to afimoxifene
CTD PMID:19901195, PMID:21233418 NCBI chr20:41,266,408...41,383,731
Ensembl chr20:41,266,566...41,383,424
JBrowse link
G Frmd6 FERM domain containing 6 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FRMD6 mRNA] CTD PMID:21233418 NCBI chr 6:93,281,382...93,358,888
Ensembl chr 6:93,281,408...93,358,840
JBrowse link
G Fut8 fucosyltransferase 8 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FUT8 mRNA] CTD PMID:21233418 NCBI chr 6:100,305,957...100,537,208
Ensembl chr 6:100,337,226...100,537,224
JBrowse link
G Fv1 Friend virus susceptibility 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of C19ORF48 mRNA] CTD PMID:21233418 NCBI chr 1:100,220,789...100,226,725
Ensembl chr 1:100,224,401...100,226,725
JBrowse link
G Fyttd1 forty-two-three domain containing 1 decreases expression ISO afimoxifene results in decreased expression of FYTTD1 mRNA CTD PMID:16514628 NCBI chr11:71,113,931...71,136,694
Ensembl chr11:71,116,579...71,136,673
JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of GAB2 mRNA] CTD PMID:21233418 NCBI chr 1:162,082,876...162,283,379
Ensembl chr 1:162,083,030...162,279,727
JBrowse link
G Galnt6 polypeptide N-acetylgalactosaminyltransferase 6 decreases expression ISO afimoxifene results in decreased expression of GALNT6 mRNA CTD PMID:16849584 NCBI chr 7:142,322,172...142,364,281
Ensembl chr 7:142,322,172...142,352,382
JBrowse link
G Gbe1 1,4-alpha-glucan branching enzyme 1 increases expression ISO afimoxifene results in increased expression of GBE1 mRNA CTD PMID:16849584 NCBI chr11:7,210,169...7,485,895
Ensembl chr11:7,210,209...7,485,890
JBrowse link
G Gga2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 increases expression ISO afimoxifene results in increased expression of GGA2 mRNA CTD PMID:16849584 NCBI chr 1:191,951,578...191,984,858
Ensembl chr 1:191,951,581...191,984,858
JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO afimoxifene promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein] CTD PMID:17272397 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gins3 GINS complex subunit 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of GINS3 mRNA] CTD PMID:21233418 NCBI chr19:9,835,113...9,843,649
Ensembl chr19:9,835,057...9,843,673
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO afimoxifene results in decreased expression of GJA1 protein CTD PMID:29180066 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Glcci1 glucocorticoid induced 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of GLCCI1 mRNA] CTD PMID:21233418 NCBI chr 4:34,282,625...34,612,709
Ensembl chr 4:34,282,625...34,614,438
JBrowse link
G Golga5 golgin A5 decreases expression ISO afimoxifene results in decreased expression of GOLGA5 mRNA CTD PMID:16514628 NCBI chr 6:126,350,572...126,378,735
Ensembl chr 6:126,353,223...126,378,610
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions
increases activity
affects response to substance
ISO GPER1 protein affects the reaction [afimoxifene results in increased cleavage of CCNE1 protein]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ATF3 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of BHLHE40 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of CCN1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of CCN2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of CEBPD mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DDIT3 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DDIT4 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP4 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP5 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of EDN1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of EDN2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of EGR1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ERRFI1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of FOS mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of FOSB mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of IER2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ITPRIP mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of JUN mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1A mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1F mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1G mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1X mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT2A mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of NFKBIA mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of NR4A2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of PPP1R15A mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of PTGER4 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RASD1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RGS16 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RND1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of TNF mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of TNFAIP3 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of TUFT1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ZFP36 mRNA]
afimoxifene results in increased activity of GPER1 protein
GPER1 protein affects the susceptibility to afimoxifene
CTD PMID:19153601, PMID:23624423 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Gpr157 G protein-coupled receptor 157 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of GPR157 mRNA] CTD PMID:21233418 NCBI chr 5:167,109,691...167,125,380
Ensembl chr 5:167,109,691...167,125,380
JBrowse link
G Gprc5d G protein-coupled receptor, class C, group 5, member D affects response to substance ISO GPRC5D gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 4:168,872,897...168,884,925
Ensembl chr 4:168,872,897...168,884,886
JBrowse link
G Gps2 G protein pathway suppressor 2 multiple interactions ISO afimoxifene promotes the reaction [GPS2 protein binds to TFF1 promoter] CTD PMID:19858209 NCBI chr10:56,524,327...56,527,447
Ensembl chr10:56,524,468...56,526,987
JBrowse link
G Grb7 growth factor receptor bound protein 7 decreases response to substance ISO GRB7 protein results in decreased susceptibility to afimoxifene CTD PMID:18351453 NCBI chr10:86,393,186...86,408,893
Ensembl chr10:86,399,827...86,409,348
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions ISO afimoxifene inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; afimoxifene inhibits the reaction [arsenic trioxide results in increased expression of GREB1 mRNA]; afimoxifene inhibits the reaction [Estrogens results in increased expression of GREB1 mRNA] CTD PMID:21233418, PMID:22558281 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Grm4 glutamate metabotropic receptor 4 increases expression ISO afimoxifene results in increased expression of GRM4 mRNA CTD PMID:23373633 NCBI chr20:6,745,682...6,791,521
Ensembl chr20:6,745,682...6,791,519
JBrowse link
G Hdac3 histone deacetylase 3 multiple interactions ISO afimoxifene promotes the reaction [HDAC3 protein binds to TFF1 promoter] CTD PMID:19858209 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Hdgf heparin binding growth factor increases expression ISO afimoxifene results in increased expression of HDGF mRNA CTD PMID:12154049 NCBI chr 2:187,274,898...187,284,670
Ensembl chr 2:187,275,120...187,284,281
JBrowse link
G Hmgb1 high mobility group box 1 decreases expression ISO afimoxifene results in decreased expression of HMGB1 mRNA CTD PMID:16514628 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO afimoxifene results in decreased expression of HNRNPA2B1 mRNA CTD PMID:16514628 NCBI chr 4:81,237,496...81,241,281
Ensembl chr 4:81,237,496...81,241,282
JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of HNRNPAB mRNA] CTD PMID:21233418 NCBI chr10:34,955,713...34,961,662
Ensembl chr10:34,955,716...34,961,608
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases expression ISO afimoxifene results in decreased expression of HNRNPH1 mRNA CTD PMID:16514628 NCBI chr10:35,872,619...35,879,911
Ensembl chr10:35,870,232...35,879,910
JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U decreases expression ISO afimoxifene results in decreased expression of HNRNPU mRNA CTD PMID:16514628 NCBI chr13:96,222,093...96,238,845
Ensembl chr13:96,225,912...96,238,572
JBrowse link
G Hoxc13 homeobox C13 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of HOXC13 mRNA] CTD PMID:21233418 NCBI chr 7:144,531,814...144,538,298
Ensembl chr 7:144,531,814...144,537,966
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO afimoxifene results in decreased expression of HSP90AB1 mRNA CTD PMID:16514628 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression ISO afimoxifene results in decreased expression of HSP90B1 mRNA CTD PMID:16514628 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 decreases expression ISO afimoxifene results in decreased expression of HSPA2 mRNA CTD PMID:19901195 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 decreases expression ISO afimoxifene results in decreased expression of HSPA4 mRNA CTD PMID:16514628 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO afimoxifene results in decreased expression of HSPA8 mRNA CTD PMID:16514628 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO afimoxifene results in increased expression of HSPB1 mRNA CTD PMID:11174852 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 multiple interactions
decreases response to substance
ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of HSPB8 mRNA]
HSPB8 results in decreased susceptibility to afimoxifene
CTD PMID:21233418 NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression ISO afimoxifene results in decreased expression of HSPD1 mRNA CTD PMID:16514628 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ID3 mRNA] CTD PMID:21233418 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Ier2 immediate early response 2 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of IER2 mRNA] CTD PMID:19153601 NCBI chr19:25,774,146...25,775,670
Ensembl chr19:25,774,143...25,775,659
JBrowse link
G Ier3 immediate early response 3 multiple interactions
increases expression
ISO [afimoxifene co-treated with Cycloheximide] results in increased expression of IER3 mRNA; Dactinomycin inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]; Estradiol inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]
afimoxifene results in increased expression of IER3 mRNA; afimoxifene results in increased expression of IER3 protein
CTD PMID:16849584 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 decreases expression ISO afimoxifene results in decreased expression of IFRD1 mRNA CTD PMID:16514628 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO afimoxifene results in increased expression of IGF1 mRNA CTD PMID:10965916 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
decreases response to substance
increases expression
ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of IGF1R mRNA]
afimoxifene results in increased phosphorylation of and results in increased activity of IGF1R protein; ESR1 protein promotes the reaction [afimoxifene results in increased phosphorylation of and results in increased activity of IGF1R protein]
IGF1R results in decreased susceptibility to afimoxifene
afimoxifene results in increased expression of IGF1R mRNA
CTD PMID:10965916, PMID:17640349, PMID:21233418 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO afimoxifene results in increased expression of IGFBP1 mRNA CTD PMID:12154049 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression ISO afimoxifene results in increased expression of IGFBP3 mRNA CTD PMID:12154049 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 multiple interactions
increases expression
ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of IGFBP4 mRNA]
afimoxifene results in increased expression of IGFBP4 mRNA
CTD PMID:15072547, PMID:19901195, PMID:21233418 NCBI chr10:86,950,555...86,962,563
Ensembl chr10:86,950,557...86,962,578
JBrowse link
G Igsf3 immunoglobulin superfamily, member 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of IGSF3 mRNA] CTD PMID:21233418 NCBI chr 2:203,768,364...203,855,573
Ensembl chr 2:203,768,117...203,855,573
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO afimoxifene results in decreased expression of IL1A mRNA CTD PMID:23373633 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL1R1 mRNA CTD PMID:25833159 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL2RG mRNA CTD PMID:25833159 NCBI chr  X:71,165,378...71,169,078
Ensembl chr  X:71,162,585...71,169,865
JBrowse link
G Il7r interleukin 7 receptor increases expression ISO afimoxifene results in increased expression of IL7R mRNA CTD PMID:12154049
G Ilrun inflammation and lipid regulator with UBA-like and NBR1-like domains decreases expression ISO afimoxifene results in decreased expression of ILRUN mRNA CTD PMID:16514628 NCBI chr20:7,331,321...7,397,588
Ensembl chr20:7,331,326...7,397,448
JBrowse link
G Ing5 inhibitor of growth family, member 5 affects response to substance ISO ING5 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 9:100,932,932...100,950,233
Ensembl chr 9:100,932,545...100,952,416
JBrowse link
G Insig2 insulin induced gene 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of INSIG2 mRNA] CTD PMID:21233418 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 decreases expression ISO afimoxifene results in decreased expression of IQGAP1 mRNA CTD PMID:16514628 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Irf2 interferon regulatory factor 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of IRF2 mRNA] CTD PMID:21233418 NCBI chr16:48,582,354...48,732,129
Ensembl chr16:48,582,026...48,732,932
JBrowse link
G Irf2bpl interferon regulatory factor 2 binding protein-like multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of IRF2BPL mRNA] CTD PMID:21233418 NCBI chr 6:110,901,940...110,904,288
Ensembl chr 6:110,901,940...110,904,288
JBrowse link
G Irs1 insulin receptor substrate 1 increases expression ISO afimoxifene results in increased expression of IRS1 mRNA CTD PMID:15072547 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Isg20l2 interferon stimulated exonuclease gene 20-like 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of ISG20L2 mRNA] CTD PMID:21233418 NCBI chr 2:187,302,192...187,311,677
Ensembl chr 2:187,302,192...187,311,676
JBrowse link
G Itpk1 inositol-tetrakisphosphate 1-kinase decreases response to substance ISO ITPK1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 6:126,448,920...126,582,188
Ensembl chr 6:126,450,139...126,582,134
JBrowse link
G Itprip inositol 1,4,5-trisphosphate receptor interacting protein multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of ITPRIP mRNA] CTD PMID:19153601 NCBI chr 1:267,649,385...267,673,341
NCBI chr 1:271,252,447...271,272,169
Ensembl chr 1:267,651,320...267,653,389
Ensembl chr 1:267,651,320...267,653,389
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO afimoxifene promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein] CTD PMID:17272397 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jak3 Janus kinase 3 decreases response to substance ISO JAK3 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
increases expression
multiple interactions
ISO afimoxifene results in increased phosphorylation of JUN protein
afimoxifene results in increased expression of JUN mRNA
Acetylcysteine inhibits the reaction [afimoxifene results in increased phosphorylation of JUN protein]; GPER1 protein affects the reaction [afimoxifene results in increased expression of JUN mRNA]
CTD PMID:19153601, PMID:19935718 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kbtbd2 kelch repeat and BTB domain containing 2 increases expression ISO afimoxifene results in increased expression of KBTBD2 mRNA CTD PMID:16849584 NCBI chr 4:87,088,759...87,111,576
Ensembl chr 4:87,088,759...87,111,025
JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 decreases expression ISO afimoxifene results in decreased expression of KCNN4 mRNA CTD PMID:19901195 NCBI chr 1:81,227,855...81,245,986
Ensembl chr 1:81,230,612...81,245,996
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO afimoxifene inhibits the reaction [Estradiol results in increased expression of KDR protein]; afimoxifene inhibits the reaction [glyphosate results in increased expression of KDR protein] CTD PMID:29890199 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Khk ketohexokinase decreases response to substance ISO KHK results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 6:26,810,577...26,821,013
Ensembl chr 6:26,810,579...26,820,959
JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO afimoxifene results in decreased expression of KIF20A mRNA CTD PMID:16514628 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814
JBrowse link
G Klc1 kinesin light chain 1 increases expression ISO afimoxifene results in increased expression of KLC1 mRNA CTD PMID:16849584 NCBI chr 6:136,330,151...136,373,716
Ensembl chr 6:136,330,383...136,373,721
JBrowse link
G Klf10 Kruppel-like factor 10 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of KLF10 mRNA] CTD PMID:21233418 NCBI chr 7:77,156,010...77,162,096
Ensembl chr 7:77,156,006...77,162,148
JBrowse link
G Klk15 kallikrein-related peptidase 15 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of KLK15 mRNA CTD PMID:25833159 NCBI chr 1:99,393,283...99,401,339
Ensembl chr 1:99,398,248...99,401,126
Ensembl chr 1:99,398,248...99,401,126
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression ISO afimoxifene results in decreased expression of KPNA2 mRNA CTD PMID:16514628 NCBI chr10:95,200,029...95,212,111
Ensembl chr10:95,200,030...95,212,111
JBrowse link
G Kpnb1 karyopherin subunit beta 1 decreases expression ISO afimoxifene results in decreased expression of KPNB1 mRNA CTD PMID:16514628 NCBI chr10:85,096,517...85,124,641
Ensembl chr10:85,093,841...85,124,644
JBrowse link
G Kras KRAS proto-oncogene, GTPase affects response to substance ISO KRAS gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Krt13 keratin 13 multiple interactions
increases expression
ISO [afimoxifene co-treated with Cycloheximide] results in increased expression of KRT13 mRNA; Estradiol inhibits the reaction [afimoxifene results in increased expression of KRT13 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of KRT13 mRNA] CTD PMID:16849584 NCBI chr10:88,032,130...88,036,040
Ensembl chr10:88,032,130...88,036,040
JBrowse link
G Krt19 keratin 19 decreases expression ISO afimoxifene results in decreased expression of KRT19 mRNA CTD PMID:17640349 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Lasp1 LIM and SH3 protein 1 increases expression ISO afimoxifene results in increased expression of LASP1 mRNA CTD PMID:16849584 NCBI chr10:85,744,662...85,785,130
Ensembl chr10:85,744,568...85,785,133
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases expression ISO afimoxifene results in decreased expression of LCK mRNA CTD PMID:23373633 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Lnx1 ligand of numb-protein X 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of LNX1 mRNA] CTD PMID:21233418 NCBI chr14:36,047,136...36,149,740
Ensembl chr14:36,047,144...36,149,740
JBrowse link
G Lrch3 leucine rich repeats and calponin homology domain containing 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of LRCH3 mRNA] CTD PMID:21233418 NCBI chr11:71,008,950...71,108,229
Ensembl chr11:71,012,061...71,108,184
JBrowse link
G Lrrfip2 LRR binding FLII interacting protein 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of LRRFIP2 mRNA] CTD PMID:21233418 NCBI chr 8:119,381,666...119,484,125
Ensembl chr 8:119,382,011...119,483,043
JBrowse link
G Lss lanosterol synthase increases expression ISO afimoxifene results in increased expression of LSS mRNA CTD PMID:16849584 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 increases expression ISO afimoxifene results in increased expression of LTBP1 mRNA CTD PMID:16849584 NCBI chr 6:21,203,502...21,600,441
Ensembl chr 6:21,203,502...21,600,451
JBrowse link
G Ltf lactotransferrin increases expression ISO afimoxifene results in increased expression of LTF protein CTD PMID:11390168 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases response to substance ISO LYN results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Lypd3 Ly6/Plaur domain containing 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of LYPD3 mRNA] CTD PMID:21233418 NCBI chr 1:81,499,856...81,504,306
Ensembl chr 1:81,499,821...81,504,318
JBrowse link
G Mall mal, T-cell differentiation protein-like increases expression
decreases expression
ISO afimoxifene results in increased expression of MALL mRNA
afimoxifene results in decreased expression of MALL mRNA
CTD PMID:19698761, PMID:19901195 NCBI chr 3:120,272,583...120,307,090
Ensembl chr 3:120,272,583...120,306,551
JBrowse link
G Maneal mannosidase, endo-alpha-like multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of MANEAL mRNA] CTD PMID:21233418 NCBI chr 5:142,850,139...142,857,292
Ensembl chr 5:142,851,526...142,857,131
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression ISO afimoxifene results in increased expression of MAP2K1 mRNA CTD PMID:12154049 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases response to substance ISO MAP2K2 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 decreases response to substance ISO MAP2K3 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 decreases response to substance ISO MAP2K4 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 decreases response to substance ISO MAP2K5 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 8:68,055,976...68,282,656
Ensembl chr 8:68,055,972...68,282,590
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 decreases response to substance ISO MAP2K6 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 decreases response to substance ISO MAP2K7 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr12:2,546,278...2,555,310
Ensembl chr12:2,548,218...2,555,164
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 decreases response to substance ISO MAP3K8 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases response to substance
multiple interactions
increases phosphorylation
ISO
EXP
MAPK1 results in decreased susceptibility to afimoxifene
afimoxifene inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]
[BRAF protein co-treated with afimoxifene] results in increased phosphorylation of MAPK1 protein; afimoxifene inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; afimoxifene inhibits the reaction [glyphosate results in increased phosphorylation of MAPK1 protein]
afimoxifene results in increased phosphorylation of MAPK1 protein
CTD PMID:19549922, PMID:21233418, PMID:23624423, PMID:25645941, PMID:29890199, PMID:30707916 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 decreases response to substance ISO MAPK11 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 7:130,121,678...130,129,199
Ensembl chr 7:130,121,687...130,128,604
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 decreases response to substance ISO MAPK12 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 7:130,109,214...130,120,918
Ensembl chr 7:130,109,663...130,120,579
JBrowse link
G Mapk13 mitogen activated protein kinase 13 decreases response to substance ISO MAPK13 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr20:6,018,374...6,027,467
Ensembl chr20:6,018,374...6,027,473
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases response to substance
multiple interactions
ISO
EXP
MAPK14 results in decreased susceptibility to afimoxifene
[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of MAPK14 mRNA
CTD PMID:21233418, PMID:25833159 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
afimoxifene results in increased phosphorylation of MAPK3 protein
afimoxifene inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]
[BRAF protein co-treated with afimoxifene] results in increased phosphorylation of MAPK3 protein; afimoxifene inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; afimoxifene inhibits the reaction [glyphosate results in increased phosphorylation of MAPK3 protein]
CTD PMID:19549922, PMID:23624423, PMID:25645941, PMID:29890199, PMID:30707916 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases response to substance ISO MAPK8 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases response to substance ISO MAPK9 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mark4 microtubule affinity regulating kinase 4 decreases response to substance ISO MARK4 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 1:80,335,517...80,367,366
Ensembl chr 1:80,335,526...80,367,328
JBrowse link
G Matr3 matrin 3 decreases expression ISO afimoxifene results in decreased expression of MATR3 mRNA CTD PMID:16514628 NCBI chr18:28,351,691...28,390,764
Ensembl chr18:28,361,283...28,390,717
JBrowse link
G Mboat2 membrane bound O-acyltransferase domain containing 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of MBOAT2 mRNA] CTD PMID:21233418 NCBI chr 6:44,009,872...44,135,501
Ensembl chr 6:44,009,872...44,131,387
JBrowse link
G Mcc MCC regulator of WNT signaling pathway multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of MCC mRNA] CTD PMID:21233418 NCBI chr18:35,683,185...35,817,117
NCBI chr 1:12,006,663...12,128,849
Ensembl chr 1:12,006,660...12,128,845
Ensembl chr18:12,006,660...12,128,845
JBrowse link
G Me1 malic enzyme 1 increases expression ISO afimoxifene results in increased expression of ME1 mRNA CTD PMID:19901195 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Meaf6 MYST/Esa1-associated factor 6 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of MEAF6 mRNA] CTD PMID:21233418 NCBI chr 5:143,081,298...143,103,225
Ensembl chr 5:143,081,326...143,103,222
JBrowse link
G Megf9 multiple EGF-like-domains 9 decreases expression ISO afimoxifene results in decreased expression of MEGF9 mRNA CTD PMID:16849584 NCBI chr 5:86,586,996...86,696,388
Ensembl chr 5:86,586,996...86,696,388
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO afimoxifene results in decreased expression of MET mRNA CTD PMID:17640349 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mgp matrix Gla protein decreases expression ISO afimoxifene results in decreased expression of MGP mRNA CTD PMID:16514628 NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225
JBrowse link
G Mir21 microRNA 21 increases expression
multiple interactions
ISO afimoxifene results in increased expression of MIR21 mRNA
afimoxifene inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]
CTD PMID:19264808 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO afimoxifene results in decreased expression of MMP12 mRNA CTD PMID:17640349 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO afimoxifene results in increased expression of MMP13 mRNA CTD PMID:17640349 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp15 matrix metallopeptidase 15 decreases expression ISO afimoxifene results in decreased expression of MMP15 mRNA CTD PMID:15072547 NCBI chr19:10,079,881...10,101,380
Ensembl chr19:10,079,765...10,101,451
JBrowse link
G Mmp16 matrix metallopeptidase 16 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of MMP16 mRNA] CTD PMID:21233418 NCBI chr 5:31,568,344...31,818,368
Ensembl chr 5:31,568,419...31,810,484
JBrowse link
G Mreg melanoregulin multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of MREG mRNA] CTD PMID:21233418 NCBI chr 9:79,490,058...79,559,768
Ensembl chr 9:79,490,050...79,545,024
JBrowse link
G Mrps2 mitochondrial ribosomal protein S2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of MRPS2 mRNA] CTD PMID:21233418 NCBI chr 3:7,051,695...7,056,726
Ensembl chr 3:7,051,695...7,058,521
JBrowse link
G Msh2 mutS homolog 2 increases expression ISO afimoxifene results in increased expression of MSH2 mRNA CTD PMID:16849584 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions
ISO afimoxifene results in increased expression of MT1A mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1A mRNA]
CTD PMID:19153601 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of MT2A mRNA] CTD PMID:19153601 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases response to substance
multiple interactions
ISO MTOR results in decreased susceptibility to afimoxifene
[Sirolimus results in decreased activity of MTOR protein] which results in increased susceptibility to afimoxifene
CTD PMID:19016759 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myb MYB proto-oncogene, transcription factor multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of MYB mRNA] CTD PMID:21233418 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression ISO afimoxifene results in increased expression of MYBL1 mRNA CTD PMID:19901195 NCBI chr 5:9,279,756...9,315,112
Ensembl chr 5:9,279,970...9,315,114
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
ISO afimoxifene results in increased expression of MYC mRNA
afimoxifene inhibits the reaction [Estradiol results in increased expression of MYC mRNA]; afimoxifene inhibits the reaction [Estrogens results in increased expression of MYC mRNA]; methylselenic acid inhibits the reaction [afimoxifene results in increased expression of MYC mRNA]; SU 6656 inhibits the reaction [afimoxifene results in increased expression of MYC mRNA]
CTD PMID:15072547, PMID:15528270, PMID:16093440, PMID:21233418, PMID:27514991 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Mylip myosin regulatory light chain interacting protein decreases expression ISO afimoxifene results in decreased expression of MYLIP mRNA CTD PMID:16849584 NCBI chr17:19,682,040...19,703,681
Ensembl chr17:19,682,040...19,703,681
JBrowse link
G Myo1b myosin Ib multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of MYO1B mRNA] CTD PMID:21233418 NCBI chr 9:54,706,005...54,766,054
Ensembl chr 9:54,558,202...54,766,054
JBrowse link
G Myof myoferlin multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of MYOF mRNA] CTD PMID:21233418 NCBI chr 1:256,585,410...256,734,727
Ensembl chr 1:256,585,410...256,734,730
JBrowse link
G Nab2 Ngfi-A binding protein 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NAB2 mRNA] CTD PMID:21233418 NCBI chr 7:70,963,580...70,971,471
Ensembl chr 7:70,961,575...70,969,905
JBrowse link
G Nae1 NEDD8 activating enzyme E1 subunit 1 affects response to substance ISO NAE1 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr19:653,510...680,378
Ensembl chr19:653,510...680,378
JBrowse link
G Nanog Nanog homeobox increases expression ISO afimoxifene results in increased expression of NANOG protein CTD PMID:27581495 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 decreases expression ISO afimoxifene results in decreased expression of NARS1 mRNA CTD PMID:16514628 NCBI chr18:59,986,350...60,002,644
Ensembl chr18:59,986,360...60,002,569
JBrowse link
G Nat9 N-acetyltransferase 9 decreases expression ISO afimoxifene results in decreased expression of NAT9 mRNA CTD PMID:16849584 NCBI chr10:103,730,215...103,737,052
Ensembl chr10:103,732,187...103,736,973
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H decreases expression ISO afimoxifene results in decreased expression of NCAPH mRNA CTD PMID:16514628 NCBI chr 3:119,583,798...119,611,148
Ensembl chr 3:119,583,648...119,611,136
JBrowse link
G Ncl nucleolin decreases expression ISO afimoxifene results in decreased expression of NCL mRNA CTD PMID:16514628 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO afimoxifene inhibits the reaction [ESRRG protein binds to NCOA1 protein] CTD PMID:11447273 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO afimoxifene inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein]; afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]; benzylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; bisphenol A inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; butylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; ethyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; ethyl-p-hydroxybenzoate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; methylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298, PMID:28248286 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO afimoxifene promotes the reaction [NCOR1 protein binds to TFF1 promoter] CTD PMID:19858209 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 decreases response to substance ISO NDUFA10 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 9:99,617,051...99,651,827
Ensembl chr 9:99,617,052...99,651,813
JBrowse link
G Nefm neurofilament medium multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of NEFM mRNA] CTD PMID:21233418 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Neil2 nei-like DNA glycosylase 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NEIL2 mRNA] CTD PMID:21233418 NCBI chr15:46,371,780...46,382,730
Ensembl chr15:46,372,485...46,381,967
JBrowse link
G Nf1 neurofibromin 1 affects response to substance ISO NF1 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
ISO afimoxifene results in increased expression of NFKBIA mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of NFKBIA mRNA]
CTD PMID:19153601 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Niban1 niban apoptosis regulator 1 increases expression ISO afimoxifene results in increased expression of NIBAN1 mRNA CTD PMID:16849584 NCBI chr13:68,949,665...69,101,600
Ensembl chr13:68,949,665...69,101,588
JBrowse link
G Nipbl NIPBL, cohesin loading factor affects response to substance ISO NIPBL gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 2:57,508,830...57,676,197
Ensembl chr 2:57,509,428...57,600,820
JBrowse link
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 decreases response to substance ISO NME3 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:14,258,232...14,259,365
Ensembl chr10:14,258,380...14,259,336
JBrowse link
G Nme4 NME/NM23 nucleoside diphosphate kinase 4 decreases response to substance ISO NME4 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:15,461,567...15,465,422
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Nme7 NME/NM23 family member 7 decreases response to substance ISO NME7 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr13:82,607,844...82,737,383
Ensembl chr13:82,626,685...82,737,343
JBrowse link
G Noc3l NOC3-like DNA replication regulator affects response to substance ISO NOC3L gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 1:257,469,538...257,498,844
Ensembl chr 1:257,469,538...257,498,844
JBrowse link
G Nolc1 nucleolar and coiled-body phosphoprotein 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NOLC1 mRNA] CTD PMID:21233418 NCBI chr 1:265,829,055...265,839,819
Ensembl chr 1:265,829,108...265,839,818
JBrowse link
G Nop56 NOP56 ribonucleoprotein multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NOP56 mRNA] CTD PMID:21233418 NCBI chr 3:122,803,726...122,808,564
Ensembl chr 3:122,803,772...122,808,558
JBrowse link
G Npepps aminopeptidase puromycin sensitive multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NPEPPS mRNA] CTD PMID:21233418 NCBI chr10:85,140,368...85,222,861
Ensembl chr10:85,140,370...85,222,861
JBrowse link
G Npm1 nucleophosmin 1 decreases expression ISO afimoxifene results in decreased expression of NPM1 mRNA CTD PMID:16514628 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Npr2 natriuretic peptide receptor 2 decreases response to substance ISO NPR2 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 5:59,128,186...59,147,321
Ensembl chr 5:59,128,315...59,147,255
JBrowse link
G Npy1r neuropeptide Y receptor Y1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NPY1R mRNA] CTD PMID:21233418 NCBI chr16:24,779,480...24,789,131
Ensembl chr16:24,779,477...24,788,740
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO afimoxifene binds to and results in increased activity of NR1I2 protein
afimoxifene results in increased activity of NR1I2 protein
CTD PMID:15885729, PMID:16054614 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO afimoxifene results in increased expression of NR4A1 mRNA CTD PMID:16514628 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of NR4A2 mRNA] CTD PMID:19153601 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression
multiple interactions
ISO afimoxifene results in increased expression of NRF1 mRNA
fulvestrant inhibits the reaction [afimoxifene results in increased expression of NRF1 mRNA]; Vehicle Emissions inhibits the reaction [afimoxifene results in increased expression of NRF1 mRNA]
CTD PMID:22105178 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Nrg3 neuregulin 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of NRG3 mRNA] CTD PMID:21233418 NCBI chr16:15,763,031...16,932,208
Ensembl chr16:15,764,632...15,798,974
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NRIP1 mRNA] CTD PMID:21233418 NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
JBrowse link
G Nsd1 nuclear receptor binding SET domain protein 1 affects response to substance ISO NSD1 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr17:9,840,859...9,955,391
Ensembl chr17:9,844,133...9,952,898
JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit decreases expression ISO afimoxifene results in decreased expression of NUS1 mRNA CTD PMID:16514628 NCBI chr20:33,557,052...33,584,011
Ensembl chr20:33,557,052...33,584,010
JBrowse link
G Nutm1 NUT midline carcinoma, family member 1 affects response to substance ISO NUTM1 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 3:103,733,981...103,745,242
Ensembl chr 3:103,734,435...103,745,236
JBrowse link
G Nxt1 nuclear transport factor 2-like export factor 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NXT1 mRNA] CTD PMID:21233418 NCBI chr 3:142,993,658...142,996,580
Ensembl chr 3:142,993,658...142,996,578
JBrowse link
G Oaz3 ornithine decarboxylase antizyme 3 increases expression ISO afimoxifene results in increased expression of OAZ3 mRNA CTD PMID:16849584 NCBI chr 2:195,675,925...195,678,859
Ensembl chr 2:195,676,048...195,678,848
JBrowse link
G Ogfod1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of OGFOD1 mRNA] CTD PMID:21233418 NCBI chr19:11,425,301...11,451,085
Ensembl chr19:11,425,105...11,451,278
JBrowse link
G Olfm1 olfactomedin 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of OLFM1 mRNA] CTD PMID:21233418 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Olfm4 olfactomedin 4 increases expression ISO afimoxifene results in increased expression of OLFM4 mRNA CTD PMID:21048224 NCBI chr15:62,384,263...62,429,450
Ensembl chr15:62,406,873...62,429,449
JBrowse link
G Pak6 p21 (RAC1) activated kinase 6 decreases response to substance ISO PAK6 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 3:110,442,175...110,486,317
Ensembl chr 3:110,442,637...110,487,526
JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 decreases response to substance ISO PAPSS1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 2:236,605,695...236,680,772
Ensembl chr 2:236,605,695...236,680,772
JBrowse link
G Pax7 paired box 7 decreases expression ISO afimoxifene results in decreased expression of PAX7 mRNA CTD PMID:23373633 NCBI chr 5:158,211,001...158,313,510
Ensembl chr 5:158,214,616...158,313,426
JBrowse link
G Pcdh8 protocadherin 8 increases expression ISO afimoxifene results in increased expression of PCDH8 mRNA CTD PMID:19901195 NCBI chr15:62,196,469...62,201,498
Ensembl chr15:62,197,060...62,200,837
JBrowse link
G Pced1b PC-esterase domain containing 1B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PCED1B mRNA] CTD PMID:21233418 NCBI chr 7:138,707,426...138,846,127
Ensembl chr 7:138,707,426...138,846,123
JBrowse link
G Pclaf PCNA clamp associated factor decreases expression ISO afimoxifene results in decreased expression of PCLAF mRNA CTD PMID:16514628 NCBI chr 8:71,514,281...71,526,182
Ensembl chr 8:71,514,281...71,526,182
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions
decreases expression
ISO afimoxifene results in increased expression of PCNA protein
[afimoxifene results in decreased susceptibility to Estradiol] which results in decreased expression of PCNA protein; [afimoxifene results in decreased susceptibility to glyphosate] which results in decreased expression of PCNA protein
afimoxifene results in decreased expression of PCNA mRNA
CTD PMID:10965916, PMID:15072547, PMID:29890199 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pcyox1 prenylcysteine oxidase 1 increases expression ISO afimoxifene results in increased expression of PCYOX1 mRNA CTD PMID:16849584 NCBI chr 4:118,187,133...118,198,029
Ensembl chr 4:118,187,134...118,198,029
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO afimoxifene results in decreased expression of PDCD4 mRNA CTD PMID:16849584 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO afimoxifene results in increased expression of PDZK1 mRNA CTD PMID:19901195 NCBI chr 2:198,965,685...198,999,323
Ensembl chr 2:198,965,685...198,999,323
JBrowse link
G Pes1 pescadillo ribosomal biogenesis factor 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of PES1 mRNA] CTD PMID:21233418 NCBI chr14:84,211,600...84,227,980
Ensembl chr14:84,211,600...84,227,978
JBrowse link
G Pgr progesterone receptor decreases expression
increases expression
multiple interactions
ISO afimoxifene results in decreased expression of PGR mRNA
afimoxifene results in increased expression of PGR mRNA
[resveratrol co-treated with pterostilbene] promotes the reaction [afimoxifene results in decreased expression of PGR mRNA]
CTD PMID:15072547, PMID:27159275 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 increases expression ISO afimoxifene results in increased expression of PGRMC1 mRNA CTD PMID:16849584 NCBI chr  X:123,205,869...123,213,880
Ensembl chr  X:123,205,869...123,213,882
JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PIK3C2B mRNA] CTD PMID:21233418 NCBI chr13:49,848,939...49,909,404
Ensembl chr13:49,850,189...49,911,202
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma decreases response to substance ISO PIK3CG results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PIK3R3 mRNA] CTD PMID:21233418 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Pkia cAMP-dependent protein kinase inhibitor alpha increases expression ISO afimoxifene results in increased expression of PKIA mRNA CTD PMID:16849584 NCBI chr 2:96,593,185...96,668,222
Ensembl chr 2:96,595,088...96,668,222
JBrowse link
G Plekhf1 pleckstrin homology and FYVE domain containing 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PLEKHF1 mRNA] CTD PMID:21233418 NCBI chr 1:94,609,041...94,616,565
Ensembl chr 1:94,609,377...94,610,854
JBrowse link
G Pls1 plastin 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PLS1 mRNA] CTD PMID:21233418 NCBI chr 8:103,557,361...103,659,625
Ensembl chr 8:103,557,364...103,608,913
JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PMP22 mRNA] CTD PMID:21233418 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Pmvk phosphomevalonate kinase decreases response to substance ISO PMVK results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 2:188,784,329...188,793,890
Ensembl chr 2:188,784,222...188,793,895
JBrowse link
G Pno1 partner of NOB1 homolog multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of PNO1 mRNA] CTD PMID:21233418 NCBI chr14:100,364,192...100,372,760
Ensembl chr14:100,364,190...100,372,760
JBrowse link
G Pnp purine nucleoside phosphorylase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of PNP mRNA] CTD PMID:21233418 NCBI chr15:27,875,883...27,883,566
Ensembl chr15:27,875,911...27,883,350
JBrowse link
G Polr2b RNA polymerase II subunit B decreases expression ISO afimoxifene results in decreased expression of POLR2B mRNA CTD PMID:16514628 NCBI chr14:33,070,104...33,107,792
Ensembl chr14:33,070,078...33,107,776
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO afimoxifene inhibits the reaction [PPARG protein binds to CD36 promoter]; afimoxifene inhibits the reaction [PPARG protein results in increased expression of CD36 mRNA]; afimoxifene results in decreased expression of and results in increased phosphorylation of PPARG protein
PPARG mRNA promotes the reaction [afimoxifene results in decreased expression of CD36 protein]
CTD PMID:27358406 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO afimoxifene inhibits the reaction [PPARGC1A protein binds to ESRRG protein] CTD PMID:16889744 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppif peptidylprolyl isomerase F multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of PPIF mRNA] CTD PMID:21233418 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D decreases expression ISO afimoxifene results in decreased expression of PPM1D mRNA CTD PMID:16514628 NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884
JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of PPM1K mRNA] CTD PMID:21233418 NCBI chr 4:88,694,395...88,721,374
Ensembl chr 4:88,694,583...88,718,533
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of PPP1R15A mRNA] CTD PMID:19153601 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B affects response to substance ISO PPP1R15B gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr13:49,933,155...49,940,961
Ensembl chr13:49,933,155...49,940,961
JBrowse link
G Ppp4r3b protein phosphatase 4, regulatory subunit 3B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PPP4R3B mRNA] CTD PMID:21233418 NCBI chr14:113,570,150...113,618,138
Ensembl chr14:113,570,150...113,618,138
JBrowse link
G Prcp prolylcarboxypeptidase decreases response to substance ISO PRCP protein results in decreased susceptibility to afimoxifene CTD PMID:21087932 NCBI chr 1:157,701,089...157,750,177
Ensembl chr 1:157,701,089...157,750,169
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 decreases response to substance ISO PRKAA1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkcd protein kinase C, delta decreases response to substance ISO PRKCD results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkcz protein kinase C, zeta decreases response to substance ISO PRKCZ results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO afimoxifene results in decreased expression of PRKDC mRNA CTD PMID:16514628 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Prodh1 proline dehydrogenase 1 decreases expression ISO afimoxifene results in decreased expression of PRODH mRNA CTD PMID:23373633 NCBI chr11:87,058,478...87,075,785
Ensembl chr11:87,058,616...87,075,785
JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 increases expression ISO afimoxifene results in increased expression of PRPS1 mRNA CTD PMID:16849584 NCBI chr  X:111,798,233...111,820,270
Ensembl chr  X:111,798,233...111,820,266
JBrowse link
G Prss8 serine protease 8 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PRSS8 mRNA] CTD PMID:21233418 NCBI chr 1:199,372,519...199,377,035
Ensembl chr 1:199,372,519...199,377,035
JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 decreases expression ISO afimoxifene results in decreased expression of PSMD14 mRNA CTD PMID:16514628 NCBI chr 3:47,578,449...47,673,330
Ensembl chr 3:47,578,384...47,673,338
JBrowse link
G Psmd6 proteasome 26S subunit, non-ATPase 6 decreases expression ISO afimoxifene results in decreased expression of PSMD6 mRNA CTD PMID:16514628 NCBI chr15:12,407,557...12,416,153
Ensembl chr15:12,407,524...12,416,105
JBrowse link
G Psme4 proteasome activator subunit 4 decreases expression ISO afimoxifene results in decreased expression of PSME4 mRNA CTD PMID:16514628 NCBI chr14:115,166,165...115,269,041
Ensembl chr14:115,166,416...115,269,056
JBrowse link
G Ptger4 prostaglandin E receptor 4 increases expression
multiple interactions
ISO afimoxifene results in increased expression of PTGER4 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of PTGER4 mRNA]
CTD PMID:19153601 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of PTGES mRNA] CTD PMID:21233418 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Pthlh parathyroid hormone-like hormone increases secretion ISO afimoxifene results in increased secretion of PTHLH protein CTD PMID:9790998 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 decreases activity ISO afimoxifene results in decreased activity of PTPN11 protein CTD PMID:17272397 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PTPN12 mRNA] CTD PMID:21233418 NCBI chr 4:10,631,129...10,702,390
Ensembl chr 4:10,631,073...10,702,386
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 decreases activity ISO afimoxifene results in decreased activity of PTPN6 protein CTD PMID:17272397 NCBI chr 4:157,239,141...157,263,890
Ensembl chr 4:157,239,142...157,263,890
JBrowse link
G Ptprg protein tyrosine phosphatase, receptor type, G multiple interactions
increases expression
ISO Estradiol inhibits the reaction [afimoxifene results in increased expression of PTPRG mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of PTPRG mRNA] CTD PMID:16849584 NCBI chr15:12,926,056...13,633,839
Ensembl chr15:12,926,167...13,228,607
JBrowse link
G Pwwp3b PWWP domain containing 3B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PWWP3B mRNA] CTD PMID:21233418 NCBI chr  X:110,375,434...110,411,221
Ensembl chr  X:110,404,022...110,411,039
JBrowse link
G Rab27b RAB27B, member RAS oncogene family multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RAB27B mRNA] CTD PMID:21233418 NCBI chr18:68,486,006...68,644,595
Ensembl chr18:68,488,942...68,551,558
JBrowse link
G Rab30 RAB30, member RAS oncogene family increases expression
multiple interactions
ISO afimoxifene results in increased expression of RAB30 mRNA
ESR2 protein inhibits the reaction [afimoxifene results in increased expression of RAB30 mRNA]; Estradiol inhibits the reaction [afimoxifene results in increased expression of RAB30 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of RAB30 mRNA]
CTD PMID:16849584 NCBI chr 1:157,573,344...157,667,973
Ensembl chr 1:157,573,324...157,660,008
JBrowse link
G Rab31 RAB31, member RAS oncogene family multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of RAB31 mRNA] CTD PMID:21233418 NCBI chr 9:113,370,072...113,504,606
Ensembl chr 9:113,370,033...113,504,605
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO afimoxifene results in decreased expression of RACGAP1 mRNA CTD PMID:16514628 NCBI chr 7:141,277,303...141,308,849
Ensembl chr 7:141,277,312...141,307,233
JBrowse link
G Rad21 RAD21 cohesin complex component affects response to substance ISO RAD21 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 7:91,511,755...91,538,673
Ensembl chr 7:91,511,756...91,538,673
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases response to substance ISO RAF1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family decreases expression ISO afimoxifene results in decreased expression of RAP1A mRNA CTD PMID:16514628 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of RARA mRNA] CTD PMID:21233418 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rarg retinoic acid receptor, gamma affects response to substance ISO RARG gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186
JBrowse link
G Rasd1 ras related dexamethasone induced 1 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of RASD1 mRNA] CTD PMID:19153601 NCBI chr10:46,330,361...46,339,326
Ensembl chr10:46,330,368...46,332,172
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 increases expression ISO afimoxifene results in increased expression of RASGRP1 mRNA CTD PMID:19901195 NCBI chr 3:108,984,029...109,044,420
Ensembl chr 3:108,984,029...109,044,420
JBrowse link
G Rbbp7 RB binding protein 7, chromatin remodeling factor decreases expression ISO afimoxifene results in decreased expression of RBBP7 mRNA CTD PMID:16514628 NCBI chr  X:33,648,682...33,665,821
Ensembl chr  X:33,648,682...33,665,821
JBrowse link
G Rbks ribokinase decreases response to substance ISO RBKS results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 6:26,051,568...26,128,762
Ensembl chr 6:26,051,396...26,128,906
JBrowse link
G Rbm24 RNA binding motif protein 24 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of RBM24 mRNA] CTD PMID:21233418 NCBI chr17:18,671,037...18,682,876
Ensembl chr17:18,671,044...18,682,876
JBrowse link
G Rcl1 RNA terminal phosphate cyclase-like 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of RCL1 mRNA] CTD PMID:21233418 NCBI chr 1:247,228,012...247,272,369
Ensembl chr 1:247,228,061...247,305,693
JBrowse link
G Ret ret proto-oncogene multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of RET mRNA] CTD PMID:21233418 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G RGD1565616 RGD1565616 decreases expression ISO afimoxifene results in decreased expression of C20ORF194 mRNA CTD PMID:19901195 NCBI chr 3:123,243,873...123,376,458
Ensembl chr 3:123,245,481...123,376,455
JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression
multiple interactions
ISO afimoxifene results in increased expression of RGS16 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of RGS16 mRNA]
CTD PMID:19153601 NCBI chr13:71,163,411...71,185,147
Ensembl chr13:71,179,910...71,185,216
JBrowse link
G Rgs3 regulator of G-protein signaling 3 increases expression ISO afimoxifene results in increased expression of RGS3 mRNA CTD PMID:16849584 NCBI chr 5:78,429,017...78,567,281
Ensembl chr 5:78,428,669...78,567,288
JBrowse link
G Rhbdf1 rhomboid 5 homolog 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RHBDF1 mRNA] CTD PMID:21233418 NCBI chr10:15,672,370...15,685,285
Ensembl chr10:15,672,382...15,685,284
JBrowse link
G Rhbdl2 rhomboid like 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RHBDL2 mRNA] CTD PMID:21233418 NCBI chr 5:141,462,579...141,511,893
Ensembl chr 5:141,491,223...141,507,892
JBrowse link
G Rhobtb1 Rho-related BTB domain containing 1 increases expression ISO afimoxifene results in increased expression of RHOBTB1 mRNA CTD PMID:19901195 NCBI chr20:20,638,579...20,715,437
Ensembl chr20:20,638,579...20,713,128
JBrowse link
G Rhot1 ras homolog family member T1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RHOT1 mRNA] CTD PMID:21233418 NCBI chr10:67,559,277...67,640,622
Ensembl chr10:67,532,030...67,640,555
JBrowse link
G Rnd1 Rho family GTPase 1 multiple interactions
increases expression
ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RND1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RND1 mRNA] CTD PMID:19153601, PMID:21233418 NCBI chr 7:140,349,138...140,356,209
Ensembl chr 7:140,349,138...140,356,209
JBrowse link
G Rnf114 ring finger protein 114 decreases expression ISO afimoxifene results in decreased expression of RNF114 mRNA CTD PMID:19698761 NCBI chr 3:164,248,736...164,260,499
Ensembl chr 3:164,248,731...164,260,497
JBrowse link
G Rpl6 ribosomal protein L6 decreases expression ISO afimoxifene results in decreased expression of RPL6 mRNA CTD PMID:16514628 NCBI chr12:40,877,578...40,882,032
Ensembl chr12:40,877,613...40,881,124
JBrowse link
G Rpp25 ribonuclease P and MRP subunit p25 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of RPP25 mRNA] CTD PMID:21233418 NCBI chr 8:62,283,336...62,284,716
Ensembl chr 8:62,283,336...62,284,716
JBrowse link
G Rps6ka6 ribosomal protein S6 kinase A6 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RPS6KA6 mRNA] CTD PMID:21233418 NCBI chr  X:82,641,679...82,743,771
Ensembl chr  X:82,641,687...82,743,753
JBrowse link
G Rps6kl1 ribosomal protein S6 kinase-like 1 decreases response to substance ISO RPS6KL1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 6:108,961,253...108,977,970
Ensembl chr 6:108,961,994...108,976,489
JBrowse link
G Rras2 RAS related 2 affects response to substance ISO RRAS2 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 1:178,940,515...179,010,257
Ensembl chr 1:178,940,516...179,010,257
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 decreases expression ISO afimoxifene results in decreased expression of RRM1 mRNA CTD PMID:16514628 NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688
JBrowse link
G Rrs1 ribosome biogenesis regulator 1 homolog multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of RRS1 mRNA] CTD PMID:21233418 NCBI chr 5:9,430,710...9,432,343
Ensembl chr 5:9,430,728...9,432,343
JBrowse link
G Rsph10b radial spoke head 10 homolog B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RSPH10B mRNA] CTD PMID:21233418 NCBI chr12:12,665,194...12,713,834
Ensembl chr12:12,665,194...12,712,742
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RXRA mRNA] CTD PMID:21233418 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Schip1 schwannomin interacting protein 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SCHIP1 mRNA] CTD PMID:21233418 NCBI chr 2:172,312,290...173,087,236
Ensembl chr 2:172,312,298...172,459,165
JBrowse link
G Scyl3 SCY1 like pseudokinase 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SCYL3 mRNA] CTD PMID:21233418 NCBI chr13:82,230,938...82,255,640
Ensembl chr13:82,231,030...82,254,318
JBrowse link
G Sdc1 syndecan 1 increases expression ISO afimoxifene results in increased expression of SDC1 mRNA CTD PMID:16849584 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SDF2L1 mRNA] CTD PMID:21233418 NCBI chr11:88,122,271...88,124,513
Ensembl chr11:88,122,271...88,124,513
JBrowse link
G Sell selectin L increases expression ISO afimoxifene results in increased expression of SELL mRNA CTD PMID:19901195 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Sema3c semaphorin 3C increases expression ISO afimoxifene results in increased expression of SEMA3C mRNA CTD PMID:19901195 NCBI chr 4:14,318,276...14,490,438
Ensembl chr 4:14,318,274...14,490,446
JBrowse link
G Serpina1 serpin family A member 1 increases expression ISO afimoxifene results in increased expression of SERPINA1 mRNA CTD PMID:16849584 NCBI chr 6:127,610,241...127,632,265
Ensembl chr 6:127,610,243...127,632,265
JBrowse link
G Serpinb9 serpin family B member 9 increases expression
multiple interactions
ISO afimoxifene results in increased expression of SERPINB9 mRNA
ESR1 protein promotes the reaction [afimoxifene results in increased expression of SERPINB9 mRNA]
CTD PMID:14617632, PMID:17237823 NCBI chr17:32,648,846...32,673,047
Ensembl chr17:32,650,441...32,661,865
JBrowse link
G Sesn1 sestrin 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SESN1 mRNA] CTD PMID:21233418 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Sfpq splicing factor proline and glutamine rich decreases expression ISO afimoxifene results in decreased expression of SFPQ mRNA CTD PMID:16514628 NCBI chr 5:145,079,803...145,088,517
Ensembl chr 5:145,079,803...145,088,498
JBrowse link
G Sfxn2 sideroflexin 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SFXN2 mRNA] CTD PMID:21233418 NCBI chr 1:266,333,440...266,345,736
Ensembl chr 1:266,333,440...266,345,697
JBrowse link
G Sgk3 serum/glucocorticoid regulated kinase family, member 3 decreases response to substance ISO SGK3 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 5:9,046,889...9,094,740
Ensembl chr 5:9,048,614...9,094,616
JBrowse link
G Sh3bp4 SH3-domain binding protein 4 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SH3BP4 mRNA] CTD PMID:21233418 NCBI chr 9:96,210,750...96,288,903
Ensembl chr 9:96,210,750...96,288,903
JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SH3RF1 mRNA] CTD PMID:21233418 NCBI chr16:32,062,425...32,227,526
Ensembl chr16:32,062,336...32,227,491
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 increases expression ISO afimoxifene results in increased expression of SHANK2 mRNA CTD PMID:16849584 NCBI chr 1:217,149,156...217,593,950
Ensembl chr 1:217,151,166...217,592,763
JBrowse link
G Shb SH2 domain containing adaptor protein B increases expression ISO afimoxifene results in increased expression of SHB mRNA CTD PMID:12154049 NCBI chr 5:60,970,650...61,077,881
Ensembl chr 5:60,971,257...61,077,627
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO afimoxifene binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Shroom2 shroom family member 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SHROOM2 mRNA] CTD PMID:21233418 NCBI chr  X:23,478,869...23,649,424
Ensembl chr  X:23,478,871...23,649,466
JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SIAH2 mRNA] CTD PMID:21233418 NCBI chr 2:148,874,151...148,891,900
Ensembl chr 2:148,874,151...148,891,900
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO afimoxifene results in decreased expression of SLC10A1 mRNA CTD PMID:29285606 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases expression ISO afimoxifene results in decreased expression of SLC1A1 mRNA CTD PMID:19901195 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC22A5 mRNA] CTD PMID:21233418 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc25a1 solute carrier family 25 member 1 increases expression ISO afimoxifene results in increased expression of SLC25A1 mRNA CTD PMID:16849584 NCBI chr11:87,204,248...87,207,265
Ensembl chr11:87,204,175...87,207,264
JBrowse link
G Slc25a15 solute carrier family 25 member 15 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC25A15 mRNA] CTD PMID:21233418 NCBI chr16:74,505,318...74,554,523
Ensembl chr16:74,531,564...74,554,529
JBrowse link
G Slc25a28 solute carrier family 25 member 28 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC25A28 mRNA] CTD PMID:21233418 NCBI chr 1:263,420,039...263,431,312
Ensembl chr 1:263,420,061...263,431,290
JBrowse link
G Slc26a2 solute carrier family 26 member 2 decreases expression
multiple interactions
ISO afimoxifene results in decreased expression of SLC26A2 mRNA
afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC26A2 mRNA]
CTD PMID:16514628, PMID:21233418 NCBI chr18:56,518,999...56,534,539
Ensembl chr18:56,520,740...56,534,415
JBrowse link
G Slc39a6 solute carrier family 39 member 6 decreases expression ISO afimoxifene results in decreased expression of SLC39A6 mRNA CTD PMID:16514628 NCBI chr18:16,523,450...16,543,992
Ensembl chr18:16,522,982...16,543,992
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC3A2 mRNA] CTD PMID:21233418 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO afimoxifene results in increased expression of SLC7A5 mRNA CTD PMID:19901195 NCBI chr19:54,693,959...54,722,563
Ensembl chr19:54,693,959...54,722,563
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SLC9A1 mRNA] CTD PMID:21233418 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
G Slit2 slit guidance ligand 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SLIT2 mRNA] CTD PMID:21233418 NCBI chr14:66,831,848...67,171,491
Ensembl chr14:66,831,848...67,170,361
JBrowse link
G Smc3 structural maintenance of chromosomes 3 affects response to substance ISO SMC3 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 1:274,310,120...274,352,856
Ensembl chr 1:274,309,758...274,352,854
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SMPD1 mRNA] CTD PMID:21233418 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Smtn smoothelin multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SMTN mRNA] CTD PMID:21233418 NCBI chr14:83,755,141...83,776,871
Ensembl chr14:83,755,142...83,776,863
JBrowse link
G Snrpd1 small nuclear ribonucleoprotein D1 polypeptide multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SNRPD1 mRNA] CTD PMID:21233418 NCBI chr18:1,866,066...1,876,613
Ensembl chr18:1,866,080...1,876,613
JBrowse link
G Socs1 suppressor of cytokine signaling 1 multiple interactions
increases expression
ISO [afimoxifene co-treated with Cycloheximide] results in increased expression of SOCS1 mRNA; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of SOCS1 mRNA]; Estradiol inhibits the reaction [afimoxifene results in increased expression of SOCS1 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of SOCS1 mRNA] CTD PMID:16849584 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Socs2 suppressor of cytokine signaling 2 increases expression ISO afimoxifene results in increased expression of SOCS2 mRNA CTD PMID:23373633 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Son SON DNA and RNA binding protein decreases expression ISO afimoxifene results in decreased expression of SON mRNA CTD PMID:16514628 NCBI chr11:31,806,598...31,837,769
Ensembl chr11:31,806,618...31,837,763
JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions
decreases expression
ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SOX9 mRNA]
afimoxifene results in decreased expression of SOX9 mRNA
CTD PMID:16849584, PMID:21233418 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Sphk1 sphingosine kinase 1 decreases response to substance ISO SPHK1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 decreases expression ISO afimoxifene results in decreased expression of SPTBN1 mRNA CTD PMID:19901195 NCBI chr14:114,517,839...114,700,199
Ensembl chr14:114,518,816...114,692,764
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 increases expression ISO afimoxifene results in increased expression of SRD5A1 mRNA CTD PMID:16849584 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link
G Srm spermidine synthase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SRM mRNA] CTD PMID:21233418 NCBI chr 5:165,405,168...165,408,325
Ensembl chr 5:165,405,168...165,408,320
JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 decreases expression ISO afimoxifene results in decreased expression of SRSF1 mRNA CTD PMID:16514628 NCBI chr10:75,334,200...75,341,197
Ensembl chr10:75,335,146...75,341,197
JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SRSF7 mRNA] CTD PMID:21233418 NCBI chr 6:2,879,312...2,886,505
Ensembl chr 6:2,880,518...2,886,465
JBrowse link
G St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ST8SIA2 mRNA] CTD PMID:21233418 NCBI chr 1:135,336,374...135,406,699
Ensembl chr 1:135,336,374...135,406,700
JBrowse link
G St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ST8SIA4 mRNA] CTD PMID:21233418 NCBI chr 9:103,117,705...103,207,154
Ensembl chr 9:103,117,506...103,207,190
JBrowse link
G Stag1 stromal antigen 1 increases expression ISO afimoxifene results in increased expression of STAG1 mRNA CTD PMID:16849584 NCBI chr 8:108,958,099...109,342,738
Ensembl chr 8:108,958,046...109,342,738
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO afimoxifene results in decreased expression of STAT1 mRNA CTD PMID:16514628 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stc2 stanniocalcin 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of STC2 mRNA] CTD PMID:21233418 NCBI chr10:16,542,909...16,552,675
Ensembl chr10:16,542,882...16,553,295
JBrowse link
G Stk26 serine/threonine kinase 26 decreases expression ISO afimoxifene results in decreased expression of STK26 mRNA CTD PMID:16514628 NCBI chr  X:138,032,356...138,096,632
Ensembl chr  X:138,046,494...138,096,669
JBrowse link
G Stkld1 serine/threonine kinase-like domain containing 1 decreases response to substance ISO STKLD1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 3:5,481,524...5,500,568
Ensembl chr 3:5,481,522...5,500,583
JBrowse link
G Stmn1 stathmin 1 decreases expression ISO afimoxifene results in decreased expression of STMN1 mRNA CTD PMID:16514628 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Stom stomatin multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of STOM mRNA] CTD PMID:21233418 NCBI chr 3:14,515,576...14,538,199
Ensembl chr 3:14,514,868...14,538,241
JBrowse link
G Strada STE20 related adaptor alpha multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of STRADA mRNA] CTD PMID:21233418 NCBI chr10:94,355,369...94,384,404
Ensembl chr10:94,355,384...94,384,339
JBrowse link
G Sts steroid sulfatase decreases expression ISO afimoxifene results in decreased expression of STS mRNA CTD PMID:16849584 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 multiple interactions ISO afimoxifene inhibits the reaction [ESR1 protein binds to STUB1 protein] CTD PMID:16037132 NCBI chr10:15,197,754...15,200,035
Ensembl chr10:15,197,803...15,200,117
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 affects response to substance
multiple interactions
increases metabolic processing
increases response to substance
increases sulfation
affects sulfation
ISO SULT1A1 protein affects the susceptibility to afimoxifene
[SULT1A1 3' UTR SNP affects the activity of SULT1A1 protein] which affects the metabolism of afimoxifene; [SULT1A1 protein results in increased metabolism of Tamoxifen] which results in increased abundance of afimoxifene
SULT1A1 protein results in increased metabolism of afimoxifene
SULT1A1 protein results in increased susceptibility to afimoxifene
SULT1A1 protein results in increased sulfation of afimoxifene
SULT1A1 gene polymorphism affects the sulfation of afimoxifene
CTD PMID:16517757, PMID:30120701 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Svil supervillin decreases expression ISO afimoxifene results in decreased expression of SVIL mRNA CTD PMID:19901195 NCBI chr17:55,230,298...55,425,967
Ensembl chr17:55,230,298...55,346,279
JBrowse link
G Sympk symplekin increases expression ISO afimoxifene results in increased expression of SYMPK mRNA CTD PMID:19698761 NCBI chr 1:79,931,097...79,959,461
Ensembl chr 1:79,931,156...79,959,461
JBrowse link
G Syt1 synaptotagmin 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SYT1 mRNA] CTD PMID:21233418 NCBI chr 7:50,084,063...50,638,996
Ensembl chr 7:50,084,060...50,638,798
JBrowse link
G Tacc1 transforming, acidic coiled-coil containing protein 1 decreases expression
multiple interactions
ISO afimoxifene results in decreased expression of TACC1 mRNA; afimoxifene results in decreased expression of TACC1 protein
afimoxifene inhibits the reaction [Estrogens results in decreased expression of TACC1 mRNA]
CTD PMID:15072547, PMID:18984771, PMID:21233418 NCBI chr16:71,596,970...71,681,126
Ensembl chr16:71,629,525...71,681,126
JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TACSTD2 mRNA] CTD PMID:21233418 NCBI chr 4:98,341,187...98,342,887
Ensembl chr 4:98,341,188...98,342,887
JBrowse link
G Taf9 TATA-box binding protein associated factor 9 decreases expression ISO afimoxifene results in decreased expression of TAF9 mRNA CTD PMID:16514628 NCBI chr 2:30,664,407...30,668,414
Ensembl chr 2:30,664,639...30,668,414
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases expression ISO afimoxifene results in decreased expression of TARS1 mRNA CTD PMID:16514628 NCBI chr 2:61,394,632...61,414,115
Ensembl chr 2:61,394,770...61,414,102
JBrowse link
G Tasor transcription activation suppressor increases expression ISO afimoxifene results in increased expression of TASOR mRNA CTD PMID:16849584 NCBI chr16:3,050,506...3,108,168
Ensembl chr16:3,051,449...3,105,531
JBrowse link
G Tatdn3 TatD DNase domain containing 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TATDN3 mRNA] CTD PMID:21233418 NCBI chr13:109,655,292...109,669,573 JBrowse link
G Tbx3 T-box transcription factor 3 multiple interactions ISO PD 173074 inhibits the reaction [afimoxifene results in increased expression of TBX3 protein] CTD PMID:21098263 NCBI chr12:42,479,518...42,494,588
Ensembl chr12:42,480,560...42,492,526
JBrowse link
G Tceal1 transcription elongation factor A like 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TCEAL1 mRNA] CTD PMID:21233418 NCBI chr  X:107,370,351...107,372,347
Ensembl chr  X:107,370,431...107,372,338
JBrowse link
G Tcf7l2 transcription factor 7 like 2 increases expression ISO afimoxifene results in increased expression of TCF7L2 mRNA CTD PMID:19901195 NCBI chr 1:276,686,911...276,730,517
Ensembl chr 1:276,659,542...276,730,514
Ensembl chr 1:276,659,542...276,730,514
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO afimoxifene results in increased expression of TFAM mRNA CTD PMID:22105178 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tfap2a transcription factor AP-2 alpha decreases expression ISO afimoxifene results in decreased expression of TFAP2A mRNA CTD PMID:19901195 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tfap4 transcription factor AP-4 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TFAP4 mRNA] CTD PMID:21233418 NCBI chr10:11,204,616...11,222,975
Ensembl chr10:11,206,226...11,223,370
JBrowse link
G Tff1 trefoil factor 1 affects binding
increases expression
multiple interactions
decreases expression
ISO [afimoxifene binds to ESR1 protein] which binds to TFF1 protein
afimoxifene results in increased expression of TFF1 mRNA
afimoxifene inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; afimoxifene inhibits the reaction [arsenic trioxide results in increased expression of TFF1 mRNA]; afimoxifene inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]; afimoxifene inhibits the reaction [Estrogens results in increased expression of TFF1 mRNA]; afimoxifene promotes the reaction [ESR1 protein binds to TFF1 promoter]; afimoxifene promotes the reaction [GPS2 protein binds to TFF1 promoter]; afimoxifene promotes the reaction [HDAC3 protein binds to TFF1 promoter]; afimoxifene promotes the reaction [NCOR1 protein binds to TFF1 promoter]; methylselenic acid inhibits the reaction [afimoxifene results in increased expression of TFF1 mRNA]; SU 6656 inhibits the reaction [afimoxifene results in increased expression of TFF1 mRNA]
afimoxifene results in decreased expression of TFF1 mRNA
CTD PMID:14617632, PMID:15072547, PMID:15528270, PMID:16093440, PMID:16514628, PMID:19593637, PMID:19698761, PMID:19858209, PMID:21233418, PMID:22558281 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TFRC mRNA] CTD PMID:21233418 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TGFB3 mRNA] CTD PMID:21233418 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Thbs2 thrombospondin 2 decreases expression ISO afimoxifene results in decreased expression of THBS2 mRNA CTD PMID:16514628 NCBI chr 1:56,653,929...56,683,571
Ensembl chr 1:56,653,938...56,683,731
JBrowse link
G Timm23 translocase of inner mitochondrial membrane 23 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TIMM23 mRNA] CTD PMID:21233418 NCBI chr16:8,324,038...8,350,067
Ensembl chr16:8,324,036...8,350,067
JBrowse link
G Tipin timeless interacting protein multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TIPIN mRNA] CTD PMID:21233418 NCBI chr 8:69,753,363...69,768,640
Ensembl chr 8:69,753,373...69,768,305
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO afimoxifene results in increased expression of TLR2 mRNA CTD PMID:23373633 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tm4sf1 transmembrane 4 L six family member 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TM4SF1 mRNA] CTD PMID:21233418 NCBI chr 2:147,382,866...147,392,062
Ensembl chr 2:147,382,866...147,392,062
JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 increases expression ISO afimoxifene results in increased expression of TM7SF2 mRNA CTD PMID:16849584 NCBI chr 1:221,426,017...221,430,340
Ensembl chr 1:221,425,987...221,431,713
JBrowse link
G Tmed8 transmembrane p24 trafficking protein family member 8 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TMED8 mRNA] CTD PMID:21233418 NCBI chr 6:111,188,938...111,222,866
Ensembl chr 6:111,194,951...111,222,858
JBrowse link
G Tmeff1 transmembrane protein with EGF-like and two follistatin-like domains 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TMEFF1 mRNA] CTD PMID:21233418 NCBI chr 5:64,326,733...64,412,531
Ensembl chr 5:64,326,733...64,412,523
JBrowse link
G Tmpo thymopoietin decreases expression ISO afimoxifene results in decreased expression of TMPO mRNA CTD PMID:16514628 NCBI chr 7:31,847,412...31,872,416
Ensembl chr 7:31,847,410...31,872,423
JBrowse link
G Tmprss2 transmembrane serine protease 2 affects response to substance ISO TMPRSS2 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of TNF mRNA] CTD PMID:19153601 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of TNFAIP3 mRNA] CTD PMID:19153601 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tnpo1 transportin 1 decreases expression ISO afimoxifene results in decreased expression of TNPO1 mRNA CTD PMID:16514628 NCBI chr 2:29,056,219...29,126,882
Ensembl chr 2:29,056,219...29,121,104
JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TOMM40 mRNA] CTD PMID:21233418 NCBI chr 1:80,617,749...80,630,253
Ensembl chr 1:80,618,154...80,630,038
JBrowse link
G Top1 DNA topoisomerase I decreases expression ISO afimoxifene results in decreased expression of TOP1 mRNA CTD PMID:16514628 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Top2b DNA topoisomerase II beta decreases expression ISO afimoxifene results in decreased expression of TOP2B mRNA CTD PMID:16514628 NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TP53INP1 mRNA] CTD PMID:21233418 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Tp53rk TP53 regulating kinase decreases response to substance ISO TP53RK results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 3:163,552,166...163,555,925
Ensembl chr 3:163,552,166...163,555,596
JBrowse link
G Tp63 tumor protein p63 increases expression ISO afimoxifene results in increased expression of TP63 mRNA CTD PMID:23373633 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Tpbg trophoblast glycoprotein multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TPBG mRNA] CTD PMID:21233418 NCBI chr 8:93,491,761...93,495,132
Ensembl chr 8:93,491,761...93,495,130
JBrowse link
G Tpd52l1 TPD52 like 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TPD52L1 mRNA] CTD PMID:21233418 NCBI chr 1:28,454,949...28,578,736
Ensembl chr 1:28,454,966...28,576,553
JBrowse link
G Tpm4 tropomyosin 4 affects response to substance ISO TPM4 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr16:19,385,810...19,399,851
Ensembl chr16:19,385,736...19,399,903
JBrowse link
G Trak2 trafficking kinesin protein 2 decreases expression ISO afimoxifene results in decreased expression of TRAK2 mRNA CTD PMID:16514628 NCBI chr 9:65,698,706...65,763,351
Ensembl chr 9:65,698,712...65,763,273
JBrowse link
G Trerf1 transcriptional regulating factor 1 decreases response to substance ISO TRERF1 protein results in decreased susceptibility to afimoxifene CTD PMID:18351453 NCBI chr 9:15,653,230...15,881,695
Ensembl chr 9:15,655,735...15,700,312
JBrowse link
G Trib1 tribbles pseudokinase 1 decreases response to substance ISO TRIB1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 7:99,954,492...99,961,026
Ensembl chr 7:99,954,492...99,961,026
JBrowse link
G Trim25 tripartite motif-containing 25 multiple interactions
increases expression
ISO afimoxifene inhibits the reaction [Estradiol results in increased expression of TRIM25 mRNA]; afimoxifene inhibits the reaction [Estradiol results in increased expression of TRIM25 protein]
afimoxifene results in increased expression of TRIM25 mRNA; afimoxifene results in increased expression of TRIM25 protein
CTD PMID:19148513 NCBI chr10:76,343,847...76,362,159
Ensembl chr10:76,343,847...76,362,145
JBrowse link
G Trmt1 tRNA methyltransferase 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TRMT1 mRNA] CTD PMID:21233418 NCBI chr19:25,798,262...25,813,458
Ensembl chr19:25,803,262...25,813,467
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TSC22D1 mRNA] CTD PMID:21233418 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TSKU mRNA] CTD PMID:21233418 NCBI chr 1:163,317,281...163,328,697
Ensembl chr 1:163,317,282...163,328,591
JBrowse link
G Tspyl5 TSPY-like 5 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TSPYL5 mRNA] CTD PMID:21233418 NCBI chr 7:72,323,764...72,328,228
Ensembl chr 7:72,326,896...72,328,128
JBrowse link
G Tuft1 tuftelin 1 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of TUFT1 mRNA] CTD PMID:19153601 NCBI chr 2:195,861,772...195,907,471
Ensembl chr 2:195,861,649...195,908,037
JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TWIST1 mRNA] CTD PMID:21233418 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression ISO afimoxifene results in decreased expression of TXNRD1 mRNA CTD PMID:16514628 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Uba3 ubiquitin-like modifier activating enzyme 3 affects response to substance ISO UBA3 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 4:129,548,411...129,569,550
Ensembl chr 4:129,548,416...129,569,470
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases expression ISO afimoxifene results in decreased expression of UGT1A1 mRNA CTD PMID:15072547 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ulk4 unc-51 like kinase 4 decreases response to substance ISO ULK4 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 8:129,631,003...129,919,080
Ensembl chr 8:129,632,149...129,919,120
JBrowse link
G Umps uridine monophosphate synthetase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of UMPS mRNA] CTD PMID:21233418 NCBI chr11:70,034,181...70,044,590
Ensembl chr11:70,034,139...70,044,628
JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO afimoxifene results in decreased expression of UNG mRNA CTD PMID:16514628 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase increases expression ISO afimoxifene results in increased expression of UPF1 mRNA CTD PMID:16849584 NCBI chr16:20,824,888...20,845,632
Ensembl chr16:20,824,864...20,845,243
JBrowse link
G Usp32 ubiquitin specific peptidase 32 decreases expression ISO afimoxifene results in decreased expression of USP32 mRNA CTD PMID:16514628 NCBI chr10:72,300,173...72,474,574
Ensembl chr10:72,300,173...72,472,675
JBrowse link
G Vdr vitamin D receptor decreases expression ISO afimoxifene results in decreased expression of VDR protein CTD PMID:8593782 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases secretion
increases expression
ISO afimoxifene inhibits the reaction [Estradiol results in increased expression of VEGFA mRNA]; afimoxifene inhibits the reaction [Estradiol results in increased expression of VEGFA protein]
afimoxifene results in increased secretion of VEGFA protein
afimoxifene results in increased expression of VEGFA mRNA; afimoxifene results in increased expression of VEGFA protein
CTD PMID:19148513, PMID:19828145 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vipr1 vasoactive intestinal peptide receptor 1 increases expression ISO afimoxifene results in increased expression of VIPR1 mRNA CTD PMID:19901195 NCBI chr 8:130,283,453...130,313,431 JBrowse link
G Vrk3 VRK serine/threonine kinase 3 decreases response to substance ISO VRK3 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 1:100,755,622...100,783,008
Ensembl chr 1:100,755,682...100,783,004
JBrowse link
G Vstm4 V-set and transmembrane domain containing 4 affects response to substance ISO VSTM4 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr16:9,088,142...9,172,855
Ensembl chr16:9,092,302...9,172,888
JBrowse link
G Vtn vitronectin multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of VTN mRNA] CTD PMID:21233418 NCBI chr10:65,767,960...65,771,040
Ensembl chr10:65,767,053...65,771,038
JBrowse link
G Wdr4 WD repeat domain 4 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of WDR4 mRNA] CTD PMID:21233418 NCBI chr20:10,240,571...10,264,818
Ensembl chr20:10,239,154...10,257,044
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of WFS1 mRNA] CTD PMID:21233418 NCBI chr14:78,640,707...78,665,224
Ensembl chr14:78,640,620...78,665,966
JBrowse link
G Wnt2 Wnt family member 2 increases expression ISO afimoxifene results in increased expression of WNT2 mRNA CTD PMID:15072547 NCBI chr 4:45,286,845...45,332,899
Ensembl chr 4:45,292,437...45,332,420
JBrowse link
G Wnt4 Wnt family member 4 increases expression ISO afimoxifene results in increased expression of WNT4 mRNA CTD PMID:16849584 NCBI chr 5:155,649,238...155,668,065
Ensembl chr 5:155,649,217...155,672,579
JBrowse link
G Wwc1 WW and C2 domain containing 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of WWC1 mRNA] CTD PMID:21233418 NCBI chr10:20,662,996...20,818,500
Ensembl chr10:20,663,541...20,818,128
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of XBP1 mRNA] CTD PMID:21233418 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Xpo1 exportin 1 decreases expression ISO afimoxifene results in decreased expression of XPO1 mRNA CTD PMID:16514628 NCBI chr14:108,007,421...108,049,088
Ensembl chr14:108,007,724...108,049,660
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression ISO afimoxifene results in decreased expression of XRCC5 mRNA CTD PMID:16514628 NCBI chr 9:79,659,275...79,748,050
Ensembl chr 9:79,659,251...79,748,078
JBrowse link
G Yrdc yrdC N(6)-threonylcarbamoyltransferase domain containing multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of YRDC mRNA] CTD PMID:21233418 NCBI chr 5:142,845,265...142,850,110
Ensembl chr 5:142,845,114...142,850,111
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta increases expression ISO afimoxifene results in increased expression of YWHAZ mRNA CTD PMID:16849584 NCBI chr 7:75,573,553...75,598,295
Ensembl chr 7:75,574,967...75,597,276
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO afimoxifene results in increased expression of ZEB1 mRNA CTD PMID:12154049 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
G Zfp148 zinc finger protein 148 increases expression ISO afimoxifene results in increased expression of ZNF148 mRNA CTD PMID:12154049 NCBI chr11:70,509,909...70,618,422
Ensembl chr11:70,514,750...70,618,347
JBrowse link
G Zfp185 zinc finger protein 185 increases expression ISO afimoxifene results in increased expression of ZNF185 mRNA CTD PMID:16849584 NCBI chr  X:152,989,099...153,034,289
Ensembl chr  X:152,999,016...153,031,444
JBrowse link
G Zfp217 zinc finger protein 217 decreases expression ISO afimoxifene results in decreased expression of ZNF217 mRNA CTD PMID:15072547 NCBI chr 3:166,981,419...167,022,349
Ensembl chr 3:166,983,220...166,994,286
JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of ZFP36 mRNA] CTD PMID:19153601 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link
G Zfp467 zinc finger protein 467 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ZNF467 mRNA] CTD PMID:21233418 NCBI chr 4:78,068,822...78,077,962
Ensembl chr 4:78,067,689...78,075,398
JBrowse link
G Zfp703 zinc finger protein 703 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of ZNF703 mRNA] CTD PMID:21233418 NCBI chr16:69,237,857...69,242,028
Ensembl chr16:69,237,857...69,242,028
JBrowse link
G Zfp704 zinc finger protein 704 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ZNF704 mRNA] CTD PMID:21233418 NCBI chr 2:94,377,059...94,559,838
Ensembl chr 2:94,377,072...94,551,529
JBrowse link
G Zfp821 zinc finger protein 821 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ZNF821 mRNA] CTD PMID:21233418 NCBI chr19:41,940,970...41,959,843
Ensembl chr19:41,941,077...41,960,083
JBrowse link
G Zwint ZW10 interacting kinetochore protein decreases expression ISO afimoxifene results in decreased expression of ZWINT mRNA CTD PMID:19698761 NCBI chr20:17,075,781...17,091,715
Ensembl chr20:17,075,771...17,091,766
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            afimoxifene 589
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        tertiary amino compound 8630
                                          tamoxifen 3231
                                            afimoxifene 589
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.