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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:afimoxifene
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Accession:CHEBI:44616 term browser browse the term
Definition:A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Synonyms:related_synonym: 4-HYDROXYTAMOXIFEN;   4-OHT;   4-monohydroxytamoxifen;   Formula=C26H29NO2;   InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-;   InChIKey=TXUZVZSFRXZGTL-QPLCGJKRSA-N;   SMILES=CC\\C(c1ccccc1)=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1
 xref: CAS:68047-06-3;   CAS:68392-35-8;   KEGG:C05011;   KEGG:D06551
 xref_mesh: MESH:C016601
 xref: PDBeChem:OHT;   PMID:15159443;   PMID:16120301;   PMID:17351746;   PMID:20006599;   PMID:22388692;   PMID:26354796;   PMID:27882656;   PMID:30937657;   PMID:31195002;   PMID:31278729;   PMID:31519767;   PMID:32103133;   PMID:32175001;   Reaxys:4910748;   Wikipedia:Afimoxifene


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afimoxifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase decreases expression ISO afimoxifene results in decreased expression of ABAT mRNA CTD PMID:16849584 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO afimoxifene results in increased expression of ABCC3 mRNA CTD PMID:15072547 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
increases expression
ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ABCC5 mRNA]
afimoxifene results in increased expression of ABCC5 mRNA
CTD PMID:15072547 PMID:21233418 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ABCG1 mRNA] CTD PMID:21233418 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Abhd17c abhydrolase domain containing 17C, depalmitoylase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ABHD17C mRNA] CTD PMID:21233418 NCBI chr 1:138,084,632...138,125,595
Ensembl chr 1:138,084,634...138,125,595
JBrowse link
G Ackr3 atypical chemokine receptor 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ACKR3 mRNA] CTD PMID:21233418 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
JBrowse link
G Ada adenosine deaminase decreases expression ISO afimoxifene results in decreased expression of ADA mRNA CTD PMID:19901195 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Adcy9 adenylate cyclase 9 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of ADCY9 mRNA] CTD PMID:21233418 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 increases expression ISO afimoxifene results in increased expression of ADGRG1 mRNA CTD PMID:16849584 NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108
JBrowse link
G Ahnak AHNAK nucleoprotein decreases expression ISO afimoxifene results in decreased expression of AHNAK mRNA CTD PMID:16514628 NCBI chr 1:205,882,223...205,970,934
Ensembl chr 1:205,882,273...205,970,926
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions
ISO afimoxifene results in increased activity of AHR protein
afimoxifene promotes the reaction [AHR protein binds to ARNT protein]; afimoxifene promotes the reaction [AHR protein binds to CYP1A1 promoter]
CTD PMID:19901195 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO afimoxifene results in increased expression of AHRR mRNA CTD PMID:19901195 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
JBrowse link
G Ak2 adenylate kinase 2 decreases response to substance ISO AK2 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632
JBrowse link
G Ak5 adenylate kinase 5 decreases response to substance ISO AK5 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 2:241,397,297...241,581,483
Ensembl chr 2:241,397,297...241,581,458
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
decreases response to substance
ISO afimoxifene results in increased phosphorylation of AKT1 protein
AKT1 protein results in decreased susceptibility to afimoxifene
CTD PMID:18351453 PMID:19549922 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases response to substance ISO AKT2 protein results in decreased susceptibility to afimoxifene CTD PMID:18351453 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ALAD mRNA] CTD PMID:21233418 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of ALOX5 mRNA CTD PMID:25833159 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of AMD1 mRNA] CTD PMID:21233418 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476
JBrowse link
G Ank3 ankyrin 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ANK3 mRNA] CTD PMID:21233418 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
JBrowse link
G Apod apolipoprotein D increases expression ISO afimoxifene results in increased expression of APOD mRNA CTD PMID:16514628 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
JBrowse link
G Ar androgen receptor decreases activity
multiple interactions
ISO afimoxifene results in decreased activity of AR protein
afimoxifene inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD PMID:9846162 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Areg amphiregulin decreases expression
increases expression
ISO afimoxifene results in decreased expression of AREG mRNA
afimoxifene results in increased expression of AREG mRNA
CTD PMID:15072547 PMID:16514628 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Arid5a AT-rich interaction domain 5A multiple interactions ISO ARID5A protein inhibits the reaction [afimoxifene results in increased activity of ESR1 protein] CTD PMID:15941852 NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO afimoxifene promotes the reaction [AHR protein binds to ARNT protein] CTD PMID:19901195 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 increases expression ISO afimoxifene results in increased expression of ARNT2 mRNA CTD PMID:16514628 NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression
increases expression
ISO afimoxifene results in decreased expression of ASCL1 mRNA
afimoxifene results in increased expression of ASCL1 mRNA
CTD PMID:16849584 PMID:19901195 NCBI chr 7:21,904,153...21,906,003
Ensembl chr 7:21,903,126...21,905,993
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO afimoxifene results in decreased expression of ASNS mRNA CTD PMID:16514628 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Atf3 activating transcription factor 3 increases expression
multiple interactions
ISO afimoxifene results in increased expression of ATF3 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of ATF3 mRNA]
CTD PMID:19153601 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atp8b2 ATPase phospholipid transporting 8B2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ATP8B2 mRNA] CTD PMID:21233418 NCBI chr 2:175,378,514...175,402,265
Ensembl chr 2:175,378,517...175,401,883
JBrowse link
G Atr ATR serine/threonine kinase decreases response to substance ISO ATR results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Aurka aurora kinase A decreases expression
decreases response to substance
ISO afimoxifene results in decreased expression of AURKA mRNA
AURKA results in decreased susceptibility to afimoxifene
CTD PMID:16514628 PMID:21233418 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 increases expression ISO afimoxifene results in increased expression of B3GNT2 mRNA CTD PMID:16849584 NCBI chr14:96,808,473...96,833,674
Ensembl chr14:96,806,664...96,835,273
JBrowse link
G Bap1 Brca1 associated protein 1 affects response to substance ISO BAP1 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535
JBrowse link
G Bbs5 Bardet-Biedl syndrome 5 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of BBS5 mRNA] CTD PMID:21233418 NCBI chr 3:54,410,429...54,431,831
Ensembl chr 3:54,410,775...54,431,829
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases response to substance ISO BCAR1 protein results in decreased susceptibility to afimoxifene CTD PMID:18351453 NCBI chr19:39,679,218...39,713,952
Ensembl chr19:39,679,204...39,713,907
JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member multiple interactions
decreases response to substance
ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of BCAR3 mRNA]
BCAR3 protein results in decreased susceptibility to afimoxifene
CTD PMID:18351453 PMID:21233418 NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO afimoxifene results in decreased expression of BCL2 mRNA
[annonacin co-treated with afimoxifene] results in decreased expression of BCL2 protein
CTD PMID:19698761 PMID:21840388 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO afimoxifene results in increased expression of BCL2L1 mRNA CTD PMID:19698761 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl3 BCL3, transcription coactivator multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of BCL3 mRNA] CTD PMID:21233418 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Bcl9l BCL9 like multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of BCL9L mRNA] CTD PMID:21233418 NCBI chr 8:44,811,977...44,840,611
Ensembl chr 8:44,811,977...44,840,611
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of BDKRB2 mRNA CTD PMID:25833159 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression
multiple interactions
ISO afimoxifene results in increased expression of BHLHE40 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of BHLHE40 mRNA]
CTD PMID:16849584 PMID:19153601 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
JBrowse link
G Bik BCL2-interacting killer increases expression ISO afimoxifene results in increased expression of BIK mRNA CTD PMID:23373633 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase decreases response to substance ISO BLK results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031
JBrowse link
G Blnk B-cell linker multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of BLNK mRNA] CTD PMID:21233418 NCBI chr 1:239,753,640...239,821,113
Ensembl chr 1:239,753,648...239,821,113
JBrowse link
G Blvrb biliverdin reductase B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of BLVRB mRNA] CTD PMID:21233418 NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of BMP7 mRNA] CTD PMID:21233418 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Bod1 biorientation of chromosomes in cell division 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of BOD1 mRNA] CTD PMID:21233418 NCBI chr10:15,993,454...15,999,795
Ensembl chr10:15,993,454...15,999,787
JBrowse link
G Bop1 BOP1 ribosomal biogenesis factor multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of BOP1 mRNA] CTD PMID:21233418 NCBI chr 7:108,172,062...108,195,875
Ensembl chr 7:108,172,066...108,195,931
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions ISO [BRAF protein co-treated with afimoxifene] results in increased expression of and results in increased activity of EGR1 protein; [BRAF protein co-treated with afimoxifene] results in increased phosphorylation of MAPK1 protein; [BRAF protein co-treated with afimoxifene] results in increased phosphorylation of MAPK3 protein CTD PMID:25645941 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Brd2 bromodomain containing 2 decreases response to substance ISO BRD2 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388
JBrowse link
G Btg1 BTG anti-proliferation factor 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of BTG1 mRNA] CTD PMID:21233418 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
JBrowse link
G C3 complement C3 increases expression ISO afimoxifene results in increased expression of C3 protein CTD PMID:11390168 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Ca12 carbonic anhydrase 12 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CA12 mRNA] CTD PMID:21233418 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440
JBrowse link
G Calcr calcitonin receptor increases expression ISO afimoxifene results in increased expression of CALCR mRNA CTD PMID:19901195 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392
JBrowse link
G Calm3 calmodulin 3 decreases response to substance ISO CALM3 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
JBrowse link
G Camk1 calcium/calmodulin-dependent protein kinase I decreases response to substance ISO CAMK1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 4:146,481,196...146,492,039
Ensembl chr 4:146,481,196...146,492,081
JBrowse link
G Cap2 cyclase associated actin cytoskeleton regulatory protein 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CAP2 mRNA] CTD PMID:21233418 NCBI chr17:18,054,234...18,203,453
Ensembl chr17:18,054,431...18,203,373
JBrowse link
G Car2 carbonic anhydrase 2 increases expression ISO afimoxifene results in increased expression of CA2 mRNA CTD PMID:19698761 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Card6 caspase recruitment domain family, member 6 increases expression ISO afimoxifene results in increased expression of CARD6 mRNA CTD PMID:23373633 NCBI chr 2:54,194,343...54,206,902
Ensembl chr 2:54,195,739...54,206,846
JBrowse link
G Cbx1 chromobox 1 decreases expression ISO afimoxifene results in decreased expression of CBX1 mRNA CTD PMID:16514628 NCBI chr10:81,770,307...81,789,981
Ensembl chr10:81,770,342...81,791,096
JBrowse link
G Ccdc88c coiled-coil domain containing 88C multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CCDC88C mRNA] CTD PMID:21233418 NCBI chr 6:120,169,752...120,289,459
Ensembl chr 6:120,169,738...120,289,555
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of CCN1 mRNA] CTD PMID:19153601 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
affects response to substance
multiple interactions
ISO afimoxifene results in increased expression of CCN2 mRNA; afimoxifene results in increased expression of CCN2 protein
CCN2 protein affects the susceptibility to afimoxifene
GPER1 protein affects the reaction [afimoxifene results in increased expression of CCN2 mRNA]
CTD PMID:19153601 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccn3 cellular communication network factor 3 decreases expression ISO afimoxifene results in decreased expression of CCN3 mRNA CTD PMID:15072547 NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019
JBrowse link
G Ccna1 cyclin A1 increases expression ISO afimoxifene results in increased expression of CCNA1 mRNA CTD PMID:12154049 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Ccna2 cyclin A2 increases expression ISO afimoxifene results in increased expression of CCNA2 mRNA CTD PMID:15072547 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnd1 cyclin D1 decreases expression
increases expression
multiple interactions
ISO afimoxifene results in decreased expression of CCND1 protein
afimoxifene results in increased expression of CCND1 mRNA
[afimoxifene co-treated with lapatinib] results in decreased expression of CCND1 protein; afimoxifene inhibits the reaction [Estrogens results in increased expression of CCND1 mRNA]
CTD PMID:15665275 PMID:17640349 PMID:21233418 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 multiple interactions
increases cleavage
ISO [afimoxifene co-treated with lapatinib] promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; afimoxifene promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; GPER1 protein affects the reaction [afimoxifene results in increased cleavage of CCNE1 protein]; U 0126 inhibits the reaction [afimoxifene results in increased cleavage of CCNE1 protein] CTD PMID:15665275 PMID:23624423 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO afimoxifene results in decreased expression of CCNE2 mRNA CTD PMID:19698761 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CCNG2 mRNA] CTD PMID:21233418 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Cd24 CD24 molecule increases expression ISO afimoxifene results in increased expression of CD24 mRNA CTD PMID:16514628 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
JBrowse link
G Cd36 CD36 molecule multiple interactions
decreases expression
ISO PPARG mRNA promotes the reaction [afimoxifene results in decreased expression of CD36 protein]
afimoxifene results in decreased expression of CD36 mRNA; afimoxifene results in decreased expression of CD36 protein
afimoxifene inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of CD36 protein]; afimoxifene inhibits the reaction [PPARG protein binds to CD36 promoter]; afimoxifene inhibits the reaction [PPARG protein results in increased expression of CD36 mRNA]; afimoxifene inhibits the reaction [Rosiglitazone results in increased expression of CD36 mRNA]; afimoxifene inhibits the reaction [Rosiglitazone results in increased expression of CD36 protein]; afimoxifene inhibits the reaction [Troglitazone results in increased expression of CD36 protein]; afimoxifene inhibits the reaction [U 0126 results in increased expression of CD36 protein]
CTD PMID:27358406 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd40 CD40 molecule multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of CD40 mRNA CTD PMID:25833159 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO afimoxifene results in increased expression of CD44 mRNA CTD PMID:16849584 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CDC6 mRNA] CTD PMID:21233418 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
JBrowse link
G Cdca7 cell division cycle associated 7 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CDCA7 mRNA] CTD PMID:21233418 NCBI chr 3:57,322,718...57,333,353
Ensembl chr 3:57,322,708...57,333,353
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]; [afimoxifene co-treated with EGF protein] results in increased expression of CDH1 mRNA; [afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein; afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]; AG 1879 inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; AG 1879 inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]; Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]]
afimoxifene results in increased expression of CDH1 mRNA; afimoxifene results in increased expression of CDH1 protein
CTD PMID:19593637 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh11 cadherin 11 decreases expression ISO afimoxifene results in decreased expression of CDH11 mRNA CTD PMID:19901195 NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases response to substance
increases expression
ISO CDK1 results in decreased susceptibility to afimoxifene
afimoxifene results in increased expression of CDK1 mRNA
CTD PMID:19901195 PMID:21233418 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk18 cyclin-dependent kinase 18 increases expression ISO afimoxifene results in increased expression of CDK18 mRNA CTD PMID:16849584 NCBI chr13:43,555,597...43,582,210
Ensembl chr13:43,556,748...43,588,525
JBrowse link
G Cdk19 cyclin-dependent kinase 19 increases expression ISO afimoxifene results in increased expression of CDK19 mRNA CTD PMID:16849584 NCBI chr20:43,770,409...43,910,629
Ensembl chr20:43,770,409...43,910,628
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [afimoxifene co-treated with lapatinib] promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; afimoxifene promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]] CTD PMID:15665275 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk9 cyclin-dependent kinase 9 decreases response to substance ISO CDK9 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CDKN1A mRNA]
afimoxifene results in increased expression of CDKN1A mRNA
CTD PMID:12154049 PMID:21233418 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO [afimoxifene co-treated with lapatinib] promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; [afimoxifene co-treated with lapatinib] results in increased expression of CDKN1B protein; afimoxifene promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]
afimoxifene results in increased expression of CDKN1B protein
afimoxifene results in increased expression of CDKN1B mRNA
CTD PMID:15665275 PMID:17640349 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CDKN2B mRNA] CTD PMID:21233418 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CDT1 mRNA] CTD PMID:21233418 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression
multiple interactions
ISO afimoxifene results in increased expression of CEBPD mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of CEBPD mRNA]
CTD PMID:19153601 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Cenpa centromere protein A decreases expression ISO afimoxifene results in decreased expression of CENPA mRNA CTD PMID:16514628 NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
JBrowse link
G Cgn cingulin multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CGN mRNA] CTD PMID:21233418 NCBI chr 2:182,308,389...182,335,747
Ensembl chr 2:182,308,714...182,334,645
JBrowse link
G Cish cytokine inducible SH2-containing protein multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CISH mRNA] CTD PMID:21233418 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
JBrowse link
G Ckb creatine kinase B decreases response to substance ISO CKB results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 decreases response to substance ISO CKMT1B results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758
JBrowse link
G Clic3 chloride intracellular channel 3 increases expression ISO afimoxifene results in increased expression of CLIC3 mRNA CTD PMID:16849584 NCBI chr 3:8,271,416...8,274,023
Ensembl chr 3:8,272,097...8,274,018
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CLIP1 mRNA] CTD PMID:21233418 NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884
JBrowse link
G Clk4 CDC-like kinase 4 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CLK4 mRNA] CTD PMID:21233418 NCBI chr10:35,523,382...35,541,387
Ensembl chr10:35,524,755...35,541,352
JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit affects response to substance ISO CLPP gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,830,311...1,837,693
JBrowse link
G Clstn1 calsyntenin 1 decreases expression ISO afimoxifene results in decreased expression of CLSTN1 mRNA CTD PMID:16514628 NCBI chr 5:160,031,235...160,094,585
Ensembl chr 5:160,031,308...160,094,583
JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein increases expression ISO afimoxifene results in increased expression of CNBP mRNA CTD PMID:12154049 NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions ISO afimoxifene inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein] CTD PMID:27936172 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO afimoxifene inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein]; afimoxifene inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein] CTD PMID:27936172 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Col4a3 collagen type IV alpha 3 chain decreases expression ISO afimoxifene results in decreased expression of COL4A3 mRNA CTD PMID:23373633 NCBI chr 9:83,875,958...84,004,955
Ensembl chr 9:83,875,561...84,001,895
JBrowse link
G Col4a6 collagen type IV alpha 6 chain decreases expression ISO afimoxifene results in decreased expression of COL4A6 mRNA CTD PMID:19901195 NCBI chr  X:104,766,463...105,117,499
Ensembl chr  X:104,766,957...105,117,500
JBrowse link
G Copb2 COPI coat complex subunit beta 2 decreases expression ISO afimoxifene results in decreased expression of COPB2 mRNA CTD PMID:16514628 NCBI chr 8:99,161,324...99,183,452 JBrowse link
G Cpm carboxypeptidase M increases expression ISO afimoxifene results in increased expression of CPM mRNA CTD PMID:16849584 NCBI chr 7:53,225,647...53,286,220
Ensembl chr 7:53,225,696...53,286,220
JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CRIM1 mRNA] CTD PMID:21233418 NCBI chr 6:16,695,864...16,870,264
Ensembl chr 6:16,697,829...16,870,259
JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of AXUD1 mRNA] CTD PMID:21233418 NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
JBrowse link
G Csta cystatin A decreases expression ISO afimoxifene results in decreased expression of CSTA mRNA CTD PMID:15072547 NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488
JBrowse link
G Ctdsp1 CTD small phosphatase 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of CTDSP1 mRNA] CTD PMID:21233418 NCBI chr 9:75,973,694...75,979,298
Ensembl chr 9:75,973,962...75,979,297
JBrowse link
G Ctsd cathepsin D increases expression ISO afimoxifene results in increased expression of CTSD mRNA CTD PMID:15072547 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctsh cathepsin H increases expression ISO afimoxifene results in increased expression of CTSH mRNA CTD PMID:16514628 NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824
JBrowse link
G Cuedc1 CUE domain containing 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CUEDC1 mRNA] CTD PMID:21233418 NCBI chr10:72,892,637...72,986,546
Ensembl chr10:72,892,637...72,986,542
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO afimoxifene inhibits the reaction [Estradiol results in increased secretion of CXCL12 protein]; afimoxifene inhibits the reaction [Estrogens results in increased expression of CXCL12 mRNA] CTD PMID:20549624 PMID:21233418 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression
multiple interactions
increases metabolic processing
ISO afimoxifene results in increased expression of CYP19A1 mRNA
[CYP19A1 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite
CTD PMID:19549922 PMID:29285606 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases metabolic processing
increases expression
ISO 3'-methoxy-4'-nitroflavone inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA]; [CYP1A1 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite; afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]]; afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; afimoxifene promotes the reaction [AHR protein binds to CYP1A1 promoter]; alpha-naphthoflavone inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA] CTD PMID:18493746 PMID:19460354 PMID:19901195 PMID:29285606 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
ISO CYP1A2 protein results in increased metabolism of afimoxifene
[CYP1A2 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite
CTD PMID:29285606 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
decreases activity
ISO afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]
afimoxifene results in increased expression of CYP1B1 mRNA
afimoxifene results in decreased activity of CYP1B1 protein
CTD PMID:12419016 PMID:19460354 PMID:19901195 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases metabolic processing
ISO [CYP2B6 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite CTD PMID:29285606 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing ISO CYP2C9 protein results in increased metabolism of afimoxifene CTD PMID:29285606 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of afimoxifene CTD PMID:29285606 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
decreases activity
ISO CYP2C8 protein results in increased metabolism of afimoxifene
afimoxifene results in decreased activity of CYP2C8 protein
CTD PMID:29285606
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases metabolic processing
ISO [CYP2D6 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite CTD PMID:29285606 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
decreases activity
increases expression
multiple interactions
increases metabolic processing
ISO afimoxifene results in increased activity of CYP3A4 protein
afimoxifene results in decreased activity of CYP3A4 protein
afimoxifene results in increased expression of CYP3A4 mRNA
[CYP3A4 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite; [CYP3A4 protein results in increased metabolism of Tamoxifen] which results in increased abundance of afimoxifene
CTD PMID:12419016 PMID:20507880 PMID:29285606 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases activity
increases metabolic processing
multiple interactions
ISO afimoxifene results in decreased activity of CYP3A5 protein
CYP3A5 protein results in increased metabolism of afimoxifene
[CYP3A5 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite
CTD PMID:12419016 PMID:29285606 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp4f39 cytochrome P450, family 4, subfamily f, polypeptide 39 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of CYP4F22 mRNA] CTD PMID:21233418 NCBI chr 7:11,426,806...11,505,553
Ensembl chr 7:11,433,371...11,536,181
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of DDIT3 mRNA] CTD PMID:19153601 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression
multiple interactions
ISO afimoxifene results in increased expression of DDIT4 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of DDIT4 mRNA]
CTD PMID:19153601 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Ddx10 DEAD-box helicase 10 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of DDX10 mRNA] CTD PMID:21233418 NCBI chr 8:53,488,656...53,643,373
Ensembl chr 8:53,488,656...53,643,373
JBrowse link
G Ddx21 DExD-box helicase 21 multiple interactions
decreases expression
ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of DDX21 mRNA]
afimoxifene results in decreased expression of DDX21 mRNA
CTD PMID:16514628 PMID:21233418 NCBI chr20:30,534,319...30,554,513
Ensembl chr20:30,534,319...30,554,543
JBrowse link
G Ddx27 DEAD-box helicase 27 decreases expression ISO afimoxifene results in decreased expression of DDX27 mRNA CTD PMID:19698761 NCBI chr 3:155,744,182...155,763,380
Ensembl chr 3:155,744,150...155,763,372
JBrowse link
G Ddx3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 decreases expression ISO afimoxifene results in decreased expression of DDX3Y mRNA CTD PMID:16514628 NCBI chr  Y:1,115,095...1,135,754
Ensembl chr  Y:1,116,309...1,135,706
JBrowse link
G Dhx33 DEAH-box helicase 33 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of DHX33 mRNA] CTD PMID:21233418 NCBI chr10:55,708,102...55,724,618
Ensembl chr10:55,705,756...55,724,567
JBrowse link
G Dhx9 DExH-box helicase 9 decreases expression ISO afimoxifene results in decreased expression of DHX9 mRNA CTD PMID:16514628 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
JBrowse link
G Dixdc1 DIX domain containing 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of DIXDC1 mRNA] CTD PMID:21233418 NCBI chr 8:51,007,835...51,081,191
Ensembl chr 8:51,007,838...51,081,090
JBrowse link
G Dkc1 dyskerin pseudouridine synthase 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of DKC1 mRNA] CTD PMID:21233418
G Dnaaf9 dynein axonemal assembly factor 9 decreases expression ISO afimoxifene results in decreased expression of DNAAF9 mRNA CTD PMID:19901195 NCBI chr 3:117,918,047...118,052,641
Ensembl chr 3:117,921,620...118,052,630
JBrowse link
G Dnah2 dynein, axonemal, heavy chain 2 decreases response to substance ISO DNAH2 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:54,142,648...54,268,901
Ensembl chr10:54,142,737...54,267,298
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 decreases expression ISO afimoxifene results in decreased expression of DNAJA1 mRNA CTD PMID:16514628 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 decreases expression ISO afimoxifene results in decreased expression of DNAJC12 mRNA CTD PMID:16849584 NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521
JBrowse link
G Drd1 dopamine receptor D1 increases expression ISO afimoxifene results in increased expression of DRD1 mRNA CTD PMID:19901195 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP1 mRNA] CTD PMID:19153601 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression
multiple interactions
ISO afimoxifene results in increased expression of DUSP4 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP4 mRNA]
CTD PMID:19153601 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression
multiple interactions
ISO afimoxifene results in increased expression of DUSP5 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP5 mRNA]
CTD PMID:19153601 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Dynll1 dynein light chain LC8-type 1 increases expression ISO afimoxifene results in increased expression of DYNLL1 mRNA CTD PMID:12154049 NCBI chr12:41,312,367...41,314,742
Ensembl chr12:41,312,367...41,314,741
JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of E2F4 mRNA] CTD PMID:21233418 NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806
JBrowse link
G Ece2 endothelin-converting enzyme 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of ECE2 mRNA] CTD PMID:21233418 NCBI chr11:80,259,130...80,299,685
Ensembl chr11:80,263,162...80,278,428
JBrowse link
G Edf1 endothelial differentiation-related factor 1 affects response to substance ISO EDF1 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 3:8,377,058...8,381,363
Ensembl chr 3:8,366,613...8,381,363
JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions
ISO afimoxifene results in increased expression of EDN1 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of EDN1 mRNA]
CTD PMID:19153601 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Edn2 endothelin 2 increases expression
multiple interactions
ISO afimoxifene results in increased expression of EDN2 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of EDN2 mRNA]
CTD PMID:19153601 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814
JBrowse link
G Efna1 ephrin A1 multiple interactions
decreases expression
ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of EFNA1 mRNA]
afimoxifene results in decreased expression of EFNA1 mRNA
CTD PMID:15072547 PMID:21233418 NCBI chr 2:174,681,676...174,690,306
Ensembl chr 2:174,681,682...174,690,866
JBrowse link
G Efnb2 ephrin B2 increases expression ISO afimoxifene results in increased expression of EFNB2 mRNA CTD PMID:16849584 NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391
JBrowse link
G Egf epidermal growth factor multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; [afimoxifene co-treated with EGF protein] results in increased expression of CDH1 mRNA; [afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein; AG 1879 inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein] CTD PMID:19593637 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor decreases response to substance ISO EGFR protein results in decreased susceptibility to afimoxifene; EGFR results in decreased susceptibility to afimoxifene CTD PMID:18351453 PMID:21233418 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO [BRAF protein co-treated with afimoxifene] results in increased expression of and results in increased activity of EGR1 protein; GPER1 protein affects the reaction [afimoxifene results in increased expression of EGR1 mRNA] CTD PMID:19153601 PMID:25645941 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr3 early growth response 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of EGR3 mRNA] CTD PMID:21233418 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha decreases expression ISO afimoxifene results in decreased expression of EIF2S1 mRNA CTD PMID:16514628 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 decreases expression ISO afimoxifene results in decreased expression of EIF5 mRNA CTD PMID:16514628
G Elf3 E74 like ETS transcription factor 3 increases expression ISO afimoxifene results in increased expression of ELF3 mRNA CTD PMID:16849584 NCBI chr13:46,690,460...46,695,394
Ensembl chr13:46,690,466...46,695,481
JBrowse link
G Elob elongin B decreases expression ISO afimoxifene results in decreased expression of ELOB mRNA CTD PMID:16514628 NCBI chr10:12,848,830...12,853,897
Ensembl chr10:12,848,827...12,853,635
JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of ELOVL2 mRNA] CTD PMID:21233418 NCBI chr17:23,544,520...23,584,855
Ensembl chr17:23,544,568...23,584,848
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 decreases expression ISO afimoxifene results in decreased expression of ELOVL5 mRNA CTD PMID:16514628 NCBI chr 8:78,790,799...78,857,307
Ensembl chr 8:78,790,846...78,857,284
JBrowse link
G Enc1 ectodermal-neural cortex 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ENC1 mRNA] CTD PMID:21233418 NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
JBrowse link
G Eno1 enolase 1 decreases response to substance ISO ENO1 mRNA results in decreased susceptibility to afimoxifene CTD PMID:19655245 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Epb41l4a erythrocyte membrane protein band 4.1 like 4A multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of EPB41L4A mRNA] CTD PMID:21233418 NCBI chr18:25,405,461...25,615,392
Ensembl chr18:25,406,057...25,615,149
JBrowse link
G Epha1 Eph receptor A1 increases expression ISO afimoxifene results in increased expression of EPHA1 mRNA CTD PMID:12154049 NCBI chr 4:71,246,409...71,260,920
Ensembl chr 4:71,246,409...71,260,846
JBrowse link
G Eps8 epidermal growth factor receptor pathway substrate 8 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of EPS8 mRNA] CTD PMID:21233418 NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases expression
decreases expression
decreases response to substance
multiple interactions
ISO afimoxifene results in increased expression of ERBB2 mRNA
afimoxifene results in decreased expression of ERBB2 mRNA
ERBB2 results in decreased susceptibility to afimoxifene
afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; afimoxifene inhibits the reaction [Estrogens results in decreased expression of ERBB2 mRNA]
CTD PMID:12439862 PMID:15072547 PMID:17640349 PMID:21233418 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions ISO afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]] CTD PMID:12439862 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of ERRFI1 mRNA] CTD PMID:19153601 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Esr1 estrogen receptor 1 increases expression
affects binding
affects folding
decreases activity
multiple interactions
ISO afimoxifene results in increased expression of ESR1 protein
[afimoxifene binds to ESR1 protein] which binds to TFF1 protein; afimoxifene binds to ESR1 protein
afimoxifene affects the folding of ESR1 protein
afimoxifene results in decreased activity of ESR1 protein
4-hydroxy-N-desmethyltamoxifen inhibits the reaction [[Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 protein]; [afimoxifene binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Equol; [afimoxifene binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Genistein; [afimoxifene results in decreased susceptibility to Estradiol] which results in decreased expression of ESR1 protein modified form; [afimoxifene results in decreased susceptibility to glyphosate] which results in increased expression of ESR1 protein modified form; [annonacin co-treated with afimoxifene] results in decreased activity of ESR1 protein; [Lapatinib co-treated with afimoxifene] results in decreased activity of ESR1 protein; [methylselenic acid co-treated with afimoxifene] results in decreased expression of ESR1 mRNA; [methylselenic acid co-treated with afimoxifene] results in decreased expression of ESR1 protein; [Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 protein; afimoxifene binds to and affects the activity of ESR1 protein; afimoxifene binds to and affects the folding of ESR1 protein; afimoxifene binds to and affects the folding of ESR1 protein mutant form; afimoxifene binds to and results in decreased activity of ESR1 protein; afimoxifene binds to and results in increased activity of ESR1 protein; afimoxifene inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; afimoxifene inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; afimoxifene inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; afimoxifene inhibits the reaction [[Chlorpyrifos co-treated with Estradiol] results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein]; afimoxifene inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [bisphenol A results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [ESR1 protein binds to STUB1 protein]; afimoxifene inhibits the reaction [Estradiol binds to ESR1 protein]; afimoxifene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; afimoxifene inhibits the reaction [fenarimol results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [glyphosate results in increased expression of ESR1 protein]; afimoxifene inhibits the reaction [Hexestrol binds to and results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [nonylphenol results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]]; afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]; afimoxifene promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]; afimoxifene promotes the reaction [ESR1 protein binds to TFF1 promoter]; afimoxifene results in increased activity of and affects the localization of ESR1 protein; ARID5A protein inhibits the reaction [afimoxifene results in increased activity of ESR1 protein]; ESR1 protein promotes the reaction [afimoxifene results in increased expression of SERPINB9 mRNA]; Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]]
afimoxifene binds to and affects the folding of ESR1 protein mutant form; ESR1 protein promotes the reaction [afimoxifene results in increased phosphorylation of and results in increased activity of IGF1R protein]
CTD PMID:9048584 PMID:9751507 PMID:9846162 PMID:10397250 PMID:10614829 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 affects expression
affects binding
multiple interactions
increases response to substance
ISO
EXP
afimoxifene affects the expression of ESR2 protein
4-hydroxytamoxifen binds to Esr2 protein
afimoxifene binds to ESR2 protein
afimoxifene binds to and results in decreased activity of ESR2 protein; afimoxifene inhibits the reaction [Estradiol binds to ESR2 protein]; afimoxifene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; afimoxifene inhibits the reaction [methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of RAB30 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of SOCS1 mRNA]
afimoxifene inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; afimoxifene inhibits the reaction [Estradiol binds to ESR2 protein alternative form]
ESR2 protein results in increased susceptibility to afimoxifene
CTD PMID:9048584 PMID:9492041 PMID:9751507 PMID:15103026 PMID:15537743 More... RGD:8694325 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
affects binding
ISO afimoxifene binds to and results in decreased activity of [ESRRG protein binds to ESRRA protein]
afimoxifene binds to ESRRA protein mutant form
CTD PMID:11447273 PMID:14751226 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions
affects binding
decreases activity
ISO
EXP
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]; 4-isopropylphenol inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]; 5,6,7,8-tetrahydro-2-naphthol inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]; afimoxifene binds to and affects the activity of ESRRG protein; afimoxifene binds to and results in decreased activity of [ESRRG protein binds to ESRRA protein]; afimoxifene binds to and results in decreased activity of ESRRG protein; afimoxifene inhibits the reaction [ESRRG protein binds to NCOA1 protein]; afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]; afimoxifene inhibits the reaction [PPARGC1A protein binds to ESRRG protein]; benzylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; bisphenol A inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]; bisphenol A inhibits the reaction [afimoxifene binds to ESRRG protein]; bisphenol A inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; bisphenol A inhibits the reaction [afimoxifene results in decreased activity of ESRRG protein]; butylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; chlorocresol inhibits the reaction [afimoxifene binds to ESRRG protein]; ethyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; ethyl-p-hydroxybenzoate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; methylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; N'-((1E)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazide inhibits the reaction [afimoxifene results in decreased activity of ESRRG protein]; propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]
afimoxifene binds to and results in decreased activity of ESRRG protein; afimoxifene inhibits the reaction [bisphenol A binds to and results in increased activity of ESRRG protein]
CTD PMID:11447273 PMID:14751226 PMID:15149736 PMID:15161930 PMID:16889744 More... NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397
JBrowse link
G Etnk1 ethanolamine kinase 1 decreases response to substance
increases expression
ISO ETNK1 results in decreased susceptibility to afimoxifene
afimoxifene results in increased expression of ETNK1 mRNA
CTD PMID:16849584 PMID:21233418 NCBI chr 4:176,126,056...176,170,325
Ensembl chr 4:176,126,180...176,193,770
JBrowse link
G Exosc2 exosome component 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of EXOSC2 mRNA] CTD PMID:21233418 NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575
JBrowse link
G Fa2h fatty acid 2-hydroxylase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FA2H mRNA] CTD PMID:21233418 NCBI chr19:39,312,904...39,364,153
Ensembl chr19:39,312,906...39,364,153
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 decreases expression ISO afimoxifene results in decreased expression of FAIM2 mRNA CTD PMID:23373633 NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168
JBrowse link
G Fam102a family with sequence similarity 102, member A multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of FAM102A mRNA] CTD PMID:21233418 NCBI chr 3:15,823,147...15,854,651
Ensembl chr 3:15,823,144...15,854,643
JBrowse link
G Fam107b family with sequence similarity 107, member B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM107B mRNA] CTD PMID:21233418 NCBI chr17:74,478,608...74,685,027
Ensembl chr17:74,478,608...74,684,989
JBrowse link
G Fam110b family with sequence similarity 110, member B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM110B mRNA] CTD PMID:21233418 NCBI chr 5:18,789,362...18,929,647
Ensembl chr 5:18,789,389...18,929,828
JBrowse link
G Fam110c family with sequence similarity 110, member C multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM110C mRNA] CTD PMID:21233418 NCBI chr 6:47,638,466...47,644,723
Ensembl chr 6:47,638,276...47,644,634
JBrowse link
G Fam204a family with sequence similarity 204, member A multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM204A mRNA] CTD PMID:21233418 NCBI chr 1:259,328,551...259,366,726
Ensembl chr 1:259,337,709...259,367,077
JBrowse link
G Fam20c FAM20C, golgi associated secretory pathway kinase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM20C mRNA] CTD PMID:21233418 NCBI chr12:15,826,864...15,885,423
Ensembl chr12:15,826,871...15,884,543
JBrowse link
G Fam43a family with sequence similarity 43, member A multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM43A mRNA] CTD PMID:21233418 NCBI chr11:70,128,253...70,131,401
Ensembl chr11:70,128,253...70,131,401
JBrowse link
G Fam83b family with sequence similarity 83, member B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM83B mRNA] CTD PMID:21233418 NCBI chr 8:77,287,351...77,363,795
Ensembl chr 8:77,287,351...77,363,795
JBrowse link
G Farp1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 increases expression
multiple interactions
ISO afimoxifene results in increased expression of FARP1 mRNA
ESR2 protein inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]; Estradiol inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]
CTD PMID:16849584 NCBI chr15:98,124,304...98,363,299
Ensembl chr15:98,182,329...98,363,299
JBrowse link
G Fbxl18 F-box and leucine-rich repeat protein 18 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FBXL18 mRNA] CTD PMID:21233418 NCBI chr12:11,674,538...11,701,317
Ensembl chr12:11,676,115...11,699,181
JBrowse link
G Flna filamin A increases expression ISO afimoxifene results in increased expression of FLNA mRNA CTD PMID:19698761 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052
JBrowse link
G Flnc filamin C decreases expression ISO afimoxifene results in decreased expression of FLNC mRNA CTD PMID:16514628 NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases secretion ISO afimoxifene results in decreased secretion of FLT1 protein CTD PMID:19828145 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO afimoxifene results in decreased expression of FN1 mRNA CTD PMID:19901195 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [afimoxifene results in increased expression of FOS mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [afimoxifene results in increased expression of FOS protein]; GPER1 protein affects the reaction [afimoxifene results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [afimoxifene results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [afimoxifene results in increased expression of FOS protein]
afimoxifene results in increased expression of FOS mRNA; afimoxifene results in increased expression of FOS protein
CTD PMID:15072547 PMID:19153601 PMID:19901195 PMID:19935718 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of FOSB mRNA] CTD PMID:19153601 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Foxp4 forkhead box P4 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FOXP4 mRNA] CTD PMID:21233418 NCBI chr 9:13,058,506...13,115,406
Ensembl chr 9:13,058,476...13,114,879
JBrowse link
G Frat1 FRAT regulator of WNT signaling pathway 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FRAT1 mRNA] CTD PMID:21233418 NCBI chr 1:240,638,288...240,640,857 JBrowse link
G Frk fyn-related Src family tyrosine kinase increases expression
decreases response to substance
ISO afimoxifene results in increased expression of FRK mRNA
FRK results in decreased susceptibility to afimoxifene
CTD PMID:19901195 PMID:21233418 NCBI chr20:38,265,416...38,371,038
Ensembl chr20:38,265,280...38,371,114
JBrowse link
G Frmd6 FERM domain containing 6 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FRMD6 mRNA] CTD PMID:21233418 NCBI chr 6:89,345,975...89,419,579
Ensembl chr 6:89,346,035...89,419,579
JBrowse link
G Fut8 fucosyltransferase 8 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of FUT8 mRNA] CTD PMID:21233418 NCBI chr 6:95,948,230...96,176,677
Ensembl chr 6:95,949,991...96,176,677
JBrowse link
G Fv1 Friend virus susceptibility 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of C19ORF48 mRNA] CTD PMID:21233418 NCBI chr 1:94,730,839...94,736,791
Ensembl chr 1:94,730,606...94,737,594
JBrowse link
G Fyttd1 forty-two-three domain containing 1 decreases expression ISO afimoxifene results in decreased expression of FYTTD1 mRNA CTD PMID:16514628 NCBI chr11:67,877,967...67,907,565
Ensembl chr11:67,877,967...67,907,511
JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of GAB2 mRNA] CTD PMID:21233418 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
JBrowse link
G Galnt6 polypeptide N-acetylgalactosaminyltransferase 6 decreases expression ISO afimoxifene results in decreased expression of GALNT6 mRNA CTD PMID:16849584 NCBI chr 7:131,789,836...131,828,077
Ensembl chr 7:131,789,839...131,819,661
JBrowse link
G Gbe1 1,4-alpha-glucan branching enzyme 1 increases expression ISO afimoxifene results in increased expression of GBE1 mRNA CTD PMID:16849584 NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210
JBrowse link
G Gga2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 increases expression ISO afimoxifene results in increased expression of GGA2 mRNA CTD PMID:16849584 NCBI chr 1:176,552,046...176,585,332
Ensembl chr 1:176,552,046...176,585,361
JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO afimoxifene promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein] CTD PMID:17272397 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Gins3 GINS complex subunit 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of GINS3 mRNA] CTD PMID:21233418 NCBI chr19:9,420,085...9,428,621
Ensembl chr19:9,420,086...9,428,687
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO afimoxifene results in decreased expression of GJA1 protein CTD PMID:29180066 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Glcci1 glucocorticoid induced 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of GLCCI1 mRNA] CTD PMID:21233418 NCBI chr 4:36,307,956...36,635,614
Ensembl chr 4:36,307,903...36,635,612
JBrowse link
G Golga5 golgin A5 decreases expression ISO afimoxifene results in decreased expression of GOLGA5 mRNA CTD PMID:16514628 NCBI chr 6:121,612,389...121,640,552
Ensembl chr 6:121,612,529...121,640,413
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions
increases activity
affects response to substance
ISO GPER1 protein affects the reaction [afimoxifene results in increased cleavage of CCNE1 protein]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ATF3 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of BHLHE40 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of CCN1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of CCN2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of CEBPD mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DDIT3 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DDIT4 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP4 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP5 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of EDN1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of EDN2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of EGR1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ERRFI1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of FOS mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of FOSB mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of IER2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ITPRIP mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of JUN mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1A mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1F mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1G mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1X mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT2A mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of NFKBIA mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of NR4A2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of PPP1R15A mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of PTGER4 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RASD1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RGS16 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RND1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of TNF mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of TNFAIP3 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of TUFT1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ZFP36 mRNA]
afimoxifene results in increased activity of GPER1 protein
GPER1 protein affects the susceptibility to afimoxifene
CTD PMID:19153601 PMID:23624423 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
JBrowse link
G Gpr157 G protein-coupled receptor 157 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of GPR157 mRNA] CTD PMID:21233418 NCBI chr 5:160,550,703...160,566,432
Ensembl chr 5:160,550,713...160,566,432
JBrowse link
G Gprc5d G protein-coupled receptor, class C, group 5, member D affects response to substance ISO GPRC5D gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 4:167,943,523...167,955,616
Ensembl chr 4:167,943,523...167,955,616
JBrowse link
G Gps2 G protein pathway suppressor 2 multiple interactions ISO afimoxifene promotes the reaction [GPS2 protein binds to TFF1 promoter] CTD PMID:19858209 NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650
JBrowse link
G Grb7 growth factor receptor bound protein 7 decreases response to substance ISO GRB7 protein results in decreased susceptibility to afimoxifene CTD PMID:18351453 NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions ISO afimoxifene inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; afimoxifene inhibits the reaction [Arsenic Trioxide results in increased expression of GREB1 mRNA]; afimoxifene inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]; afimoxifene inhibits the reaction [Estrogens results in increased expression of GREB1 mRNA] CTD PMID:21233418 PMID:22558281 PMID:33769548 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Grm4 glutamate metabotropic receptor 4 increases expression ISO afimoxifene results in increased expression of GRM4 mRNA CTD PMID:23373633 NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821
JBrowse link
G Hdac3 histone deacetylase 3 multiple interactions ISO afimoxifene promotes the reaction [HDAC3 protein binds to TFF1 promoter] CTD PMID:19858209 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
JBrowse link
G Hdgf heparin binding growth factor increases expression ISO afimoxifene results in increased expression of HDGF mRNA CTD PMID:12154049 NCBI chr 2:173,370,147...173,379,756
Ensembl chr 2:173,370,465...173,379,747
JBrowse link
G Hmgb1 high mobility group box 1 decreases expression ISO afimoxifene results in decreased expression of HMGB1 mRNA CTD PMID:16514628 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO afimoxifene results in decreased expression of HNRNPA2B1 mRNA CTD PMID:16514628 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of HNRNPAB mRNA] CTD PMID:21233418 NCBI chr10:35,857,040...35,862,935
Ensembl chr10:35,857,041...35,863,344
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases expression ISO afimoxifene results in decreased expression of HNRNPH1 mRNA CTD PMID:16514628 NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846
JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U decreases expression ISO afimoxifene results in decreased expression of HNRNPU mRNA CTD PMID:16514628 NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588
JBrowse link
G Hoxc13 homeobox C13 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of HOXC13 mRNA] CTD PMID:21233418 NCBI chr 7:134,058,640...134,065,479
Ensembl chr 7:134,058,640...134,064,800
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO afimoxifene results in decreased expression of HSP90AB1 mRNA CTD PMID:16514628 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression ISO afimoxifene results in decreased expression of HSP90B1 mRNA CTD PMID:16514628 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 decreases expression ISO afimoxifene results in decreased expression of HSPA2 mRNA CTD PMID:19901195 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 decreases expression ISO afimoxifene results in decreased expression of HSPA4 mRNA CTD PMID:16514628 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO afimoxifene results in decreased expression of HSPA8 mRNA CTD PMID:16514628 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO afimoxifene results in increased expression of HSPB1 mRNA CTD PMID:11174852 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 multiple interactions
decreases response to substance
ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of HSPB8 mRNA]
HSPB8 results in decreased susceptibility to afimoxifene
CTD PMID:21233418 NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression ISO afimoxifene results in decreased expression of HSPD1 mRNA CTD PMID:16514628 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ID3 mRNA] CTD PMID:21233418 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Ier2 immediate early response 2 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of IER2 mRNA] CTD PMID:19153601 NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211
JBrowse link
G Ier3 immediate early response 3 multiple interactions
increases expression
ISO [afimoxifene co-treated with Cycloheximide] results in increased expression of IER3 mRNA; Dactinomycin inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]; Estradiol inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]
afimoxifene results in increased expression of IER3 mRNA; afimoxifene results in increased expression of IER3 protein
CTD PMID:16849584 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 decreases expression ISO afimoxifene results in decreased expression of IFRD1 mRNA CTD PMID:16514628 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO afimoxifene results in increased expression of IGF1 mRNA CTD PMID:10965916 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
decreases response to substance
increases expression
ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of IGF1R mRNA]
afimoxifene results in increased phosphorylation of and results in increased activity of IGF1R protein; ESR1 protein promotes the reaction [afimoxifene results in increased phosphorylation of and results in increased activity of IGF1R protein]
IGF1R results in decreased susceptibility to afimoxifene
afimoxifene results in increased expression of IGF1R mRNA
CTD PMID:10965916 PMID:17640349 PMID:21233418 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO afimoxifene results in increased expression of IGFBP1 mRNA CTD PMID:12154049 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression ISO afimoxifene results in increased expression of IGFBP3 mRNA CTD PMID:12154049 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 multiple interactions
increases expression
ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of IGFBP4 mRNA]
afimoxifene results in increased expression of IGFBP4 mRNA
CTD PMID:15072547 PMID:19901195 PMID:21233418 NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225
JBrowse link
G Igsf3 immunoglobulin superfamily, member 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of IGSF3 mRNA] CTD PMID:21233418 NCBI chr 2:188,811,394...188,899,645
Ensembl chr 2:188,811,380...188,899,645
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO afimoxifene results in decreased expression of IL1A mRNA CTD PMID:23373633 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL1R1 mRNA CTD PMID:25833159 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL2RG mRNA CTD PMID:25833159 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823
JBrowse link
G Il7r interleukin 7 receptor increases expression ISO afimoxifene results in increased expression of IL7R mRNA CTD PMID:12154049 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
JBrowse link
G Ilrun inflammation and lipid regulator with UBA-like and NBR1-like domains decreases expression ISO afimoxifene results in decreased expression of ILRUN mRNA CTD PMID:16514628 NCBI chr20:5,809,931...5,876,231
Ensembl chr20:5,809,936...5,876,012
JBrowse link
G Ing5 inhibitor of growth family, member 5 affects response to substance ISO ING5 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 9:94,326,919...94,344,220
Ensembl chr 9:94,326,548...94,344,220
JBrowse link
G Insig2 insulin induced gene 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of INSIG2 mRNA] CTD PMID:21233418 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 decreases expression ISO afimoxifene results in decreased expression of IQGAP1 mRNA CTD PMID:16514628 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755
JBrowse link
G Irf2 interferon regulatory factor 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of IRF2 mRNA] CTD PMID:21233418 NCBI chr16:45,439,215...45,550,054
Ensembl chr16:45,439,225...45,550,024
JBrowse link
G Irf2bpl interferon regulatory factor 2 binding protein-like multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of IRF2BPL mRNA] CTD PMID:21233418 NCBI chr 6:106,527,179...106,531,294
Ensembl chr 6:106,528,053...106,530,401
JBrowse link
G Irs1 insulin receptor substrate 1 increases expression ISO afimoxifene results in increased expression of IRS1 mRNA CTD PMID:15072547 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Isg20l2 interferon stimulated exonuclease gene 20-like 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of ISG20L2 mRNA] CTD PMID:21233418 NCBI chr 2:173,396,780...173,407,102
Ensembl chr 2:173,396,780...173,406,614
JBrowse link
G Itpk1 inositol-tetrakisphosphate 1-kinase decreases response to substance ISO ITPK1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 6:121,710,750...121,844,501
Ensembl chr 6:121,710,755...121,844,107
JBrowse link
G Itprip inositol 1,4,5-trisphosphate receptor interacting protein multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of ITPRIP mRNA] CTD PMID:19153601 NCBI chr 1:246,762,804...246,786,364
Ensembl chr 1:246,762,472...246,786,408
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO afimoxifene promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein] CTD PMID:17272397 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jak3 Janus kinase 3 decreases response to substance ISO JAK3 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
increases expression
multiple interactions
ISO afimoxifene results in increased phosphorylation of JUN protein
afimoxifene results in increased expression of JUN mRNA
Acetylcysteine inhibits the reaction [afimoxifene results in increased phosphorylation of JUN protein]; GPER1 protein affects the reaction [afimoxifene results in increased expression of JUN mRNA]
CTD PMID:19153601 PMID:19935718 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kbtbd2 kelch repeat and BTB domain containing 2 increases expression ISO afimoxifene results in increased expression of KBTBD2 mRNA CTD PMID:16849584 NCBI chr 4:86,027,947...86,050,266
Ensembl chr 4:86,027,947...86,050,211
JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 decreases expression ISO afimoxifene results in decreased expression of KCNN4 mRNA CTD PMID:19901195 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO afimoxifene inhibits the reaction [Estradiol results in increased expression of KDR protein]; afimoxifene inhibits the reaction [glyphosate results in increased expression of KDR protein] CTD PMID:29890199 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Khk ketohexokinase decreases response to substance ISO KHK results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 6:25,445,298...25,455,834
Ensembl chr 6:25,445,300...25,455,717
JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO afimoxifene results in decreased expression of KIF20A mRNA CTD PMID:16514628 NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
JBrowse link
G Klc1 kinesin light chain 1 increases expression ISO afimoxifene results in increased expression of KLC1 mRNA CTD PMID:16849584 NCBI chr 6:130,823,416...130,866,729
Ensembl chr 6:130,823,419...130,867,031
JBrowse link
G Klf10 Kruppel-like factor 10 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of KLF10 mRNA] CTD PMID:21233418 NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
JBrowse link
G Klk15 kallikrein-related peptidase 15 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of KLK15 mRNA CTD PMID:25833159 NCBI chr 1:94,699,422...94,706,626
Ensembl chr 1:94,703,158...94,706,329
Ensembl chr 1:94,703,158...94,706,329
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression ISO afimoxifene results in decreased expression of KPNA2 mRNA CTD PMID:16514628 NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150
JBrowse link
G Kpnb1 karyopherin subunit beta 1 decreases expression ISO afimoxifene results in decreased expression of KPNB1 mRNA CTD PMID:16514628 NCBI chr10:82,145,662...82,174,437
Ensembl chr10:82,145,420...82,174,605
JBrowse link
G Kras KRAS proto-oncogene, GTPase affects response to substance ISO KRAS gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Krt13 keratin 13 multiple interactions
increases expression
ISO [afimoxifene co-treated with Cycloheximide] results in increased expression of KRT13 mRNA; Estradiol inhibits the reaction [afimoxifene results in increased expression of KRT13 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of KRT13 mRNA] CTD PMID:16849584 NCBI chr10:85,052,122...85,056,032
Ensembl chr10:85,051,889...85,056,084
JBrowse link
G Krt19 keratin 19 decreases expression ISO afimoxifene results in decreased expression of KRT19 mRNA CTD PMID:17640349 NCBI chr10:85,075,835...85,080,552 JBrowse link
G Lasp1 LIM and SH3 protein 1 increases expression ISO afimoxifene results in increased expression of LASP1 mRNA CTD PMID:16849584 NCBI chr10:82,795,177...82,835,659
Ensembl chr10:82,795,137...82,943,292
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases expression ISO afimoxifene results in decreased expression of LCK mRNA CTD PMID:23373633 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Lnx1 ligand of numb-protein X 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of LNX1 mRNA] CTD PMID:21233418 NCBI chr14:33,514,429...33,617,086
Ensembl chr14:33,514,436...33,617,086
JBrowse link
G LOC100361087 hypothetical LOC100361087 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of C1ORF226 mRNA] CTD PMID:21233418 NCBI chr13:82,533,538...82,538,676
Ensembl chr13:82,530,577...82,820,949
JBrowse link
G Lrch3 leucine rich repeats and calponin homology domain containing 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of LRCH3 mRNA] CTD PMID:21233418 NCBI chr11:67,772,499...67,872,269
Ensembl chr11:67,772,506...67,872,264
JBrowse link
G Lrrfip2 LRR binding FLII interacting protein 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of LRRFIP2 mRNA] CTD PMID:21233418 NCBI chr 8:111,091,453...111,193,947
Ensembl chr 8:111,091,503...111,193,255
JBrowse link
G Lss lanosterol synthase increases expression ISO afimoxifene results in increased expression of LSS mRNA CTD PMID:16849584 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 increases expression ISO afimoxifene results in increased expression of LTBP1 mRNA CTD PMID:16849584 NCBI chr 6:20,029,629...20,425,339
Ensembl chr 6:20,029,629...20,425,349
JBrowse link
G Ltf lactotransferrin increases expression ISO afimoxifene results in increased expression of LTF protein CTD PMID:11390168 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases response to substance ISO LYN results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Lypd3 Ly6/Plaur domain containing 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of LYPD3 mRNA] CTD PMID:21233418 NCBI chr 1:80,226,449...80,230,901
Ensembl chr 1:80,226,449...80,230,901
JBrowse link
G Mall mal, T-cell differentiation protein-like increases expression
decreases expression
ISO afimoxifene results in increased expression of MALL mRNA
afimoxifene results in decreased expression of MALL mRNA
CTD PMID:19698761 PMID:19901195 NCBI chr 3:114,927,897...114,950,840
Ensembl chr 3:114,927,897...114,950,785
JBrowse link
G Maneal mannosidase, endo-alpha-like multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of MANEAL mRNA] CTD PMID:21233418 NCBI chr 5:137,115,154...137,122,299
Ensembl chr 5:137,115,632...137,122,353
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression ISO afimoxifene results in increased expression of MAP2K1 mRNA CTD PMID:12154049 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases response to substance ISO MAP2K2 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 decreases response to substance ISO MAP2K3 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 decreases response to substance ISO MAP2K4 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 decreases response to substance ISO MAP2K5 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 decreases response to substance ISO MAP2K6 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 decreases response to substance ISO MAP2K7 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr12:2,591,312...2,604,211
Ensembl chr12:2,591,219...2,604,222
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 decreases response to substance ISO MAP3K8 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases response to substance
multiple interactions
increases phosphorylation
ISO
EXP
MAPK1 results in decreased susceptibility to afimoxifene
afimoxifene inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]
[BRAF protein co-treated with afimoxifene] results in increased phosphorylation of MAPK1 protein; afimoxifene inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; afimoxifene inhibits the reaction [glyphosate results in increased phosphorylation of MAPK1 protein]
afimoxifene results in increased phosphorylation of MAPK1 protein
CTD PMID:19549922 PMID:21233418 PMID:23624423 PMID:25645941 PMID:29890199 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 decreases response to substance ISO MAPK11 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 decreases response to substance ISO MAPK12 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
JBrowse link
G Mapk13 mitogen activated protein kinase 13 decreases response to substance ISO MAPK13 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases response to substance
multiple interactions
ISO
EXP
MAPK14 results in decreased susceptibility to afimoxifene
[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of MAPK14 mRNA
CTD PMID:21233418 PMID:25833159 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
afimoxifene results in increased phosphorylation of MAPK3 protein
afimoxifene inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]
[BRAF protein co-treated with afimoxifene] results in increased phosphorylation of MAPK3 protein; afimoxifene inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; afimoxifene inhibits the reaction [glyphosate results in increased phosphorylation of MAPK3 protein]
CTD PMID:19549922 PMID:23624423 PMID:25645941 PMID:29890199 PMID:30707916 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases response to substance ISO MAPK8 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases response to substance ISO MAPK9 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mark4 microtubule affinity regulating kinase 4 decreases response to substance ISO MARK4 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 1:79,075,353...79,108,882
Ensembl chr 1:79,068,904...79,108,556
JBrowse link
G Matr3 matrin 3 decreases expression ISO afimoxifene results in decreased expression of MATR3 mRNA CTD PMID:16514628 NCBI chr18:27,154,098...27,193,212
Ensembl chr18:27,163,714...27,193,166
JBrowse link
G Mboat2 membrane bound O-acyltransferase domain containing 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of MBOAT2 mRNA] CTD PMID:21233418 NCBI chr 6:41,471,135...41,597,599
Ensembl chr 6:41,471,161...41,593,485
JBrowse link
G Mcc MCC regulator of WNT signaling pathway multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of MCC mRNA] CTD PMID:21233418 NCBI chr18:36,794,206...37,266,237
Ensembl chr18:36,798,372...37,266,819
JBrowse link
G Me1 malic enzyme 1 increases expression ISO afimoxifene results in increased expression of ME1 mRNA CTD PMID:19901195 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Meaf6 MYST/Esa1-associated factor 6 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of MEAF6 mRNA] CTD PMID:21233418 NCBI chr 5:137,344,681...137,369,703
Ensembl chr 5:137,344,380...137,370,014
JBrowse link
G Megf9 multiple EGF-like-domains 9 decreases expression ISO afimoxifene results in decreased expression of MEGF9 mRNA CTD PMID:16849584 NCBI chr 5:83,993,565...84,105,622
Ensembl chr 5:83,993,565...84,105,622
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO afimoxifene results in decreased expression of MET mRNA CTD PMID:17640349 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mgp matrix Gla protein decreases expression ISO afimoxifene results in decreased expression of MGP mRNA CTD PMID:16514628 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
JBrowse link
G Mir21 microRNA 21 increases expression
multiple interactions
ISO afimoxifene results in increased expression of MIR21 mRNA
afimoxifene inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]
CTD PMID:19264808 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO afimoxifene results in decreased expression of MMP12 mRNA CTD PMID:17640349 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO afimoxifene results in increased expression of MMP13 mRNA CTD PMID:17640349 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp15 matrix metallopeptidase 15 decreases expression ISO afimoxifene results in decreased expression of MMP15 mRNA CTD PMID:15072547 NCBI chr19:9,663,449...9,684,943
Ensembl chr19:9,663,449...9,684,943
JBrowse link
G Mmp16 matrix metallopeptidase 16 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of MMP16 mRNA] CTD PMID:21233418 NCBI chr 5:31,312,280...31,556,276
Ensembl chr 5:31,312,280...31,548,388
JBrowse link
G Mreg melanoregulin multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of MREG mRNA] CTD PMID:21233418 NCBI chr 9:73,786,727...73,842,081
Ensembl chr 9:73,787,267...73,842,087
JBrowse link
G Mrps2 mitochondrial ribosomal protein S2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of MRPS2 mRNA] CTD PMID:21233418 NCBI chr 3:11,801,310...11,806,341
Ensembl chr 3:11,801,310...11,806,313
JBrowse link
G Msh2 mutS homolog 2 increases expression ISO afimoxifene results in increased expression of MSH2 mRNA CTD PMID:16849584 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions
ISO afimoxifene results in increased expression of MT1A mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1A mRNA]
CTD PMID:19153601 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of MT2A mRNA] CTD PMID:19153601 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases response to substance
multiple interactions
ISO MTOR results in decreased susceptibility to afimoxifene
[Sirolimus results in decreased activity of MTOR protein] which results in increased susceptibility to afimoxifene
CTD PMID:19016759 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myb MYB proto-oncogene, transcription factor multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of MYB mRNA] CTD PMID:21233418 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression ISO afimoxifene results in increased expression of MYBL1 mRNA CTD PMID:19901195 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
ISO afimoxifene results in increased expression of MYC mRNA
afimoxifene inhibits the reaction [Estradiol results in increased expression of MYC mRNA]; afimoxifene inhibits the reaction [Estrogens results in increased expression of MYC mRNA]; methylselenic acid inhibits the reaction [afimoxifene results in increased expression of MYC mRNA]; SU 6656 inhibits the reaction [afimoxifene results in increased expression of MYC mRNA]
CTD PMID:15072547 PMID:15528270 PMID:16093440 PMID:21233418 PMID:27514991 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Mylip myosin regulatory light chain interacting protein decreases expression ISO afimoxifene results in decreased expression of MYLIP mRNA CTD PMID:16849584 NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295
JBrowse link
G Myo1b myosin Ib multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of MYO1B mRNA] CTD PMID:21233418 NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798
JBrowse link
G Myof myoferlin multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of MYOF mRNA] CTD PMID:21233418 NCBI chr 1:235,673,666...235,822,413
Ensembl chr 1:235,673,666...235,822,334
JBrowse link
G Nab2 Ngfi-A binding protein 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NAB2 mRNA] CTD PMID:21233418 NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989
JBrowse link
G Nae1 NEDD8 activating enzyme E1 subunit 1 affects response to substance ISO NAE1 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr19:446,015...472,145
Ensembl chr19:446,000...472,371
JBrowse link
G Nanog Nanog homeobox increases expression ISO afimoxifene results in increased expression of NANOG protein CTD PMID:27581495 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 decreases expression ISO afimoxifene results in decreased expression of NARS1 mRNA CTD PMID:16514628 NCBI chr18:57,989,308...58,005,639
Ensembl chr18:57,989,308...58,005,622
JBrowse link
G Nat9 N-acetyltransferase 9 decreases expression ISO afimoxifene results in decreased expression of NAT9 mRNA CTD PMID:16849584 NCBI chr10:100,422,326...100,427,510
Ensembl chr10:100,422,331...100,427,611
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H decreases expression ISO afimoxifene results in decreased expression of NCAPH mRNA CTD PMID:16514628 NCBI chr 3:114,371,937...114,399,223
Ensembl chr 3:114,371,941...114,399,180
JBrowse link
G Ncl nucleolin decreases expression ISO afimoxifene results in decreased expression of NCL mRNA CTD PMID:16514628 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO afimoxifene inhibits the reaction [ESRRG protein binds to NCOA1 protein] CTD PMID:11447273 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO afimoxifene inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein]; afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]; benzylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; bisphenol A inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; butylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; ethyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; ethyl-p-hydroxybenzoate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; methylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 PMID:28248286 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO afimoxifene promotes the reaction [NCOR1 protein binds to TFF1 promoter] CTD PMID:19858209 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 decreases response to substance ISO NDUFA10 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560
JBrowse link
G Nefm neurofilament medium chain multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of NEFM mRNA] CTD PMID:21233418 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Neil2 nei-like DNA glycosylase 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NEIL2 mRNA] CTD PMID:21233418 NCBI chr15:37,444,676...37,454,863
Ensembl chr15:37,445,381...37,454,863
JBrowse link
G Nf1 neurofibromin 1 affects response to substance ISO NF1 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
ISO afimoxifene results in increased expression of NFKBIA mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of NFKBIA mRNA]
CTD PMID:19153601 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Niban1 niban apoptosis regulator 1 increases expression ISO afimoxifene results in increased expression of NIBAN1 mRNA CTD PMID:16849584 NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729
JBrowse link
G Nipbl NIPBL, cohesin loading factor affects response to substance ISO NIPBL gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 2:57,399,443...57,586,770
Ensembl chr 2:57,399,445...57,565,899
JBrowse link
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 decreases response to substance ISO NME3 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:13,917,309...13,918,415
Ensembl chr10:13,917,403...13,918,359
JBrowse link
G Nme4 NME/NM23 nucleoside diphosphate kinase 4 decreases response to substance ISO NME4 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:15,114,624...15,118,479 JBrowse link
G Nme7 NME/NM23 family member 7 decreases response to substance ISO NME7 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr13:76,657,303...76,786,768
Ensembl chr13:76,657,367...76,786,765
JBrowse link
G Noc3l NOC3-like DNA replication regulator affects response to substance ISO NOC3L gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 1:236,556,037...236,585,372
Ensembl chr 1:236,556,789...236,585,318
JBrowse link
G Nolc1 nucleolar and coiled-body phosphoprotein 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NOLC1 mRNA] CTD PMID:21233418 NCBI chr 1:244,921,275...244,932,089
Ensembl chr 1:244,921,377...244,932,088
JBrowse link
G Nop56 NOP56 ribonucleoprotein multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NOP56 mRNA] CTD PMID:21233418 NCBI chr 3:117,476,963...117,481,847
Ensembl chr 3:117,477,053...117,481,841
JBrowse link
G Npepps aminopeptidase puromycin sensitive multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NPEPPS mRNA] CTD PMID:21233418 NCBI chr10:82,191,454...82,273,967
Ensembl chr10:82,191,456...82,273,967
JBrowse link
G Npm1 nucleophosmin 1 decreases expression ISO afimoxifene results in decreased expression of NPM1 mRNA CTD PMID:16514628 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
JBrowse link
G Npr2 natriuretic peptide receptor 2 decreases response to substance ISO NPR2 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 5:57,883,171...57,901,590
Ensembl chr 5:57,883,171...57,901,580
JBrowse link
G Npy1r neuropeptide Y receptor Y1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NPY1R mRNA] CTD PMID:21233418 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO afimoxifene binds to and results in increased activity of NR1I2 protein
afimoxifene results in increased activity of NR1I2 protein
CTD PMID:15885729 PMID:16054614 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO afimoxifene results in increased expression of NR4A1 mRNA CTD PMID:16514628 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of NR4A2 mRNA] CTD PMID:19153601 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression
multiple interactions
ISO afimoxifene results in increased expression of NRF1 mRNA
fulvestrant inhibits the reaction [afimoxifene results in increased expression of NRF1 mRNA]; Vehicle Emissions inhibits the reaction [afimoxifene results in increased expression of NRF1 mRNA]
CTD PMID:22105178 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Nrg3 neuregulin 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of NRG3 mRNA] CTD PMID:21233418 NCBI chr16:14,229,270...15,352,505 JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NRIP1 mRNA] CTD PMID:21233418 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
JBrowse link
G Nsd1 nuclear receptor binding SET domain protein 1 affects response to substance ISO NSD1 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr17:9,311,963...9,426,373
Ensembl chr17:9,315,237...9,425,358
JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit decreases expression ISO afimoxifene results in decreased expression of NUS1 mRNA CTD PMID:16514628 NCBI chr20:31,811,817...31,838,562
Ensembl chr20:31,811,817...31,838,561
JBrowse link
G Nutm1 NUT midline carcinoma, family member 1 affects response to substance ISO NUTM1 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 3:99,053,510...99,064,311
Ensembl chr 3:99,053,510...99,064,311
JBrowse link
G Nxt1 nuclear transport factor 2-like export factor 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of NXT1 mRNA] CTD PMID:21233418 NCBI chr 3:136,108,975...136,111,897
Ensembl chr 3:136,108,862...136,111,907
JBrowse link
G Oaz3 ornithine decarboxylase antizyme 3 increases expression ISO afimoxifene results in increased expression of OAZ3 mRNA CTD PMID:16849584 NCBI chr 2:182,073,212...182,076,147
Ensembl chr 2:182,073,215...182,082,399
JBrowse link
G Ogfod1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of OGFOD1 mRNA] CTD PMID:21233418 NCBI chr19:10,948,778...10,974,566
Ensembl chr19:10,946,018...10,975,119
JBrowse link
G Olfm1 olfactomedin 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of OLFM1 mRNA] CTD PMID:21233418 NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239
JBrowse link
G Olfm4 olfactomedin 4 increases expression ISO afimoxifene results in increased expression of OLFM4 mRNA CTD PMID:21048224 NCBI chr15:55,385,100...55,429,687
Ensembl chr15:55,407,148...55,429,681
JBrowse link
G Pak6 p21 (RAC1) activated kinase 6 decreases response to substance ISO PAK6 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 3:105,638,248...105,674,399
Ensembl chr 3:105,638,653...105,672,975
JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 decreases response to substance ISO PAPSS1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 2:220,040,338...220,114,399
Ensembl chr 2:220,040,312...220,114,395
JBrowse link
G Pax7 paired box 7 decreases expression ISO afimoxifene results in decreased expression of PAX7 mRNA CTD PMID:23373633 NCBI chr 5:151,996,368...152,098,023
Ensembl chr 5:151,999,092...152,097,979
JBrowse link
G Pcdh8 protocadherin 8 increases expression ISO afimoxifene results in increased expression of PCDH8 mRNA CTD PMID:19901195 NCBI chr15:55,198,475...55,203,021
Ensembl chr15:55,198,459...55,205,872
JBrowse link
G Pced1b PC-esterase domain containing 1B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PCED1B mRNA] CTD PMID:21233418 NCBI chr 7:128,394,388...128,528,231
Ensembl chr 7:128,391,319...128,528,231
JBrowse link
G Pclaf PCNA clamp associated factor decreases expression ISO afimoxifene results in decreased expression of PCLAF mRNA CTD PMID:16514628 NCBI chr 8:66,420,673...66,432,568
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions
decreases expression
ISO afimoxifene results in increased expression of PCNA protein
[afimoxifene results in decreased susceptibility to Estradiol] which results in decreased expression of PCNA protein; [afimoxifene results in decreased susceptibility to glyphosate] which results in decreased expression of PCNA protein
afimoxifene results in decreased expression of PCNA mRNA
CTD PMID:10965916 PMID:15072547 PMID:29890199 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pcyox1 prenylcysteine oxidase 1 increases expression ISO afimoxifene results in increased expression of PCYOX1 mRNA CTD PMID:16849584 NCBI chr 4:118,832,114...118,842,951
Ensembl chr 4:118,830,638...118,842,951
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO afimoxifene results in decreased expression of PDCD4 mRNA CTD PMID:16849584 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO afimoxifene results in increased expression of PDZK1 mRNA CTD PMID:19901195 NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514
JBrowse link
G Pes1 pescadillo ribosomal biogenesis factor 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of PES1 mRNA] CTD PMID:21233418 NCBI chr14:78,850,754...78,867,134
Ensembl chr14:78,850,709...78,867,134
JBrowse link
G Pgr progesterone receptor decreases expression
increases expression
multiple interactions
ISO afimoxifene results in decreased expression of PGR mRNA
afimoxifene results in increased expression of PGR mRNA
[Resveratrol co-treated with pterostilbene] promotes the reaction [afimoxifene results in decreased expression of PGR mRNA]; afimoxifene inhibits the reaction [Estradiol results in increased expression of PGR mRNA]
CTD PMID:15072547 PMID:27159275 PMID:33769548 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 increases expression ISO afimoxifene results in increased expression of PGRMC1 mRNA CTD PMID:16849584 NCBI chr  X:115,832,865...115,841,060
Ensembl chr  X:115,832,884...115,888,682
JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PIK3C2B mRNA] CTD PMID:21233418 NCBI chr13:44,494,673...44,555,663
Ensembl chr13:44,495,050...44,555,612
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma decreases response to substance ISO PIK3CG results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PIK3R3 mRNA] CTD PMID:21233418 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
JBrowse link
G Pkia cAMP-dependent protein kinase inhibitor alpha increases expression ISO afimoxifene results in increased expression of PKIA mRNA CTD PMID:16849584 NCBI chr 2:94,398,869...94,473,638
Ensembl chr 2:94,398,869...94,414,282
JBrowse link
G Plekhf1 pleckstrin homology and FYVE domain containing 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PLEKHF1 mRNA] CTD PMID:21233418 NCBI chr 1:90,908,304...90,915,862
Ensembl chr 1:90,904,742...90,915,820
JBrowse link
G Pls1 plastin 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PLS1 mRNA] CTD PMID:21233418 NCBI chr 8:96,316,703...96,426,592
Ensembl chr 8:96,317,849...96,385,195
JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PMP22 mRNA] CTD PMID:21233418 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
JBrowse link
G Pmvk phosphomevalonate kinase decreases response to substance ISO PMVK results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364
JBrowse link
G Pno1 partner of NOB1 homolog multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of PNO1 mRNA] CTD PMID:21233418 NCBI chr14:91,609,711...91,618,280
Ensembl chr14:91,609,233...91,618,324
JBrowse link
G Pnp purine nucleoside phosphorylase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of PNP mRNA] CTD PMID:21233418 NCBI chr15:24,170,456...24,178,274
Ensembl chr15:24,170,602...24,203,986
JBrowse link
G Polr2b RNA polymerase II subunit B decreases expression ISO afimoxifene results in decreased expression of POLR2B mRNA CTD PMID:16514628 NCBI chr14:30,797,228...30,834,916
Ensembl chr14:30,797,228...30,834,916
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO afimoxifene binds to and results in increased activity of PPARG protein; afimoxifene inhibits the reaction [PPARG protein binds to CD36 promoter]; afimoxifene inhibits the reaction [PPARG protein results in increased expression of CD36 mRNA]; afimoxifene results in decreased expression of and results in increased phosphorylation of PPARG protein
afimoxifene binds to and results in increased activity of PPARG protein; PPARG mRNA promotes the reaction [afimoxifene results in decreased expression of CD36 protein]
CTD PMID:27358406 PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO afimoxifene inhibits the reaction [PPARGC1A protein binds to ESRRG protein] CTD PMID:16889744 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppif peptidylprolyl isomerase F multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of PPIF mRNA] CTD PMID:21233418 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D decreases expression ISO afimoxifene results in decreased expression of PPM1D mRNA CTD PMID:16514628 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of PPM1K mRNA] CTD PMID:21233418 NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of PPP1R15A mRNA] CTD PMID:19153601 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B affects response to substance ISO PPP1R15B gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737
JBrowse link
G Ppp4r3b protein phosphatase 4, regulatory subunit 3B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PPP4R3B mRNA] CTD PMID:21233418 NCBI chr14:102,917,043...102,965,210
Ensembl chr14:102,917,443...103,068,192
JBrowse link
G Prcp prolylcarboxypeptidase decreases response to substance ISO PRCP protein results in decreased susceptibility to afimoxifene CTD PMID:21087932 NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 decreases response to substance ISO PRKAA1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkcd protein kinase C, delta decreases response to substance ISO PRKCD results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkcz protein kinase C, zeta decreases response to substance ISO PRKCZ results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO afimoxifene results in decreased expression of PRKDC mRNA CTD PMID:16514628 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Prodh1 proline dehydrogenase 1 decreases expression ISO afimoxifene results in decreased expression of PRODH mRNA CTD PMID:23373633 NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305
JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 increases expression ISO afimoxifene results in increased expression of PRPS1 mRNA CTD PMID:16849584 NCBI chr  X:104,132,139...104,154,191
Ensembl chr  X:104,132,141...104,154,187
JBrowse link
G Prss8 serine protease 8 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PRSS8 mRNA] CTD PMID:21233418 NCBI chr 1:182,536,229...182,540,745
Ensembl chr 1:182,536,229...182,540,815
JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 decreases expression ISO afimoxifene results in decreased expression of PSMD14 mRNA CTD PMID:16514628 NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076
JBrowse link
G Psmd6 proteasome 26S subunit, non-ATPase 6 decreases expression ISO afimoxifene results in decreased expression of PSMD6 mRNA CTD PMID:16514628 NCBI chr15:11,102,208...11,112,180
Ensembl chr15:11,102,180...11,205,620
JBrowse link
G Psme4 proteasome activator subunit 4 decreases expression ISO afimoxifene results in decreased expression of PSME4 mRNA CTD PMID:16514628 NCBI chr14:104,505,716...104,609,410
Ensembl chr14:104,505,716...104,609,408
JBrowse link
G Ptger4 prostaglandin E receptor 4 increases expression
multiple interactions
ISO afimoxifene results in increased expression of PTGER4 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of PTGER4 mRNA]
CTD PMID:19153601 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of PTGES mRNA] CTD PMID:21233418 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Pthlh parathyroid hormone-like hormone increases secretion ISO afimoxifene results in increased secretion of PTHLH protein CTD PMID:9790998 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 decreases activity ISO afimoxifene results in decreased activity of PTPN11 protein CTD PMID:17272397 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PTPN12 mRNA] CTD PMID:21233418 NCBI chr 4:14,020,997...14,092,931
Ensembl chr 4:14,021,052...14,092,927
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 decreases activity ISO afimoxifene results in decreased activity of PTPN6 protein CTD PMID:17272397 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
JBrowse link
G Ptprg protein tyrosine phosphatase, receptor type, G multiple interactions
increases expression
ISO Estradiol inhibits the reaction [afimoxifene results in increased expression of PTPRG mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of PTPRG mRNA] CTD PMID:16849584 NCBI chr15:12,872,284...13,552,186
Ensembl chr15:12,871,721...13,554,094
JBrowse link
G Pwwp3b PWWP domain containing 3B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of PWWP3B mRNA] CTD PMID:21233418 NCBI chr  X:102,804,416...102,838,580
Ensembl chr  X:102,804,520...102,838,574
JBrowse link
G Rab27b RAB27B, member RAS oncogene family multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RAB27B mRNA] CTD PMID:21233418 NCBI chr18:63,597,554...63,794,124
Ensembl chr18:63,600,937...63,757,180
JBrowse link
G Rab30 RAB30, member RAS oncogene family increases expression
multiple interactions
ISO afimoxifene results in increased expression of RAB30 mRNA
ESR2 protein inhibits the reaction [afimoxifene results in increased expression of RAB30 mRNA]; Estradiol inhibits the reaction [afimoxifene results in increased expression of RAB30 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of RAB30 mRNA]
CTD PMID:16849584 NCBI chr 1:146,803,652...146,898,369
Ensembl chr 1:146,803,714...146,892,181
JBrowse link
G Rab31 RAB31, member RAS oncogene family multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of RAB31 mRNA] CTD PMID:21233418 NCBI chr 9:105,246,712...105,382,973
Ensembl chr 9:105,246,709...105,381,253
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO afimoxifene results in decreased expression of RACGAP1 mRNA CTD PMID:16514628 NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831
JBrowse link
G Rad21 RAD21 cohesin complex component affects response to substance ISO RAD21 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases response to substance ISO RAF1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family decreases expression ISO afimoxifene results in decreased expression of RAP1A mRNA CTD PMID:16514628 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of RARA mRNA] CTD PMID:21233418 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rarg retinoic acid receptor, gamma affects response to substance ISO RARG gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
JBrowse link
G Rasd1 ras related dexamethasone induced 1 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of RASD1 mRNA] CTD PMID:19153601 NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 increases expression ISO afimoxifene results in increased expression of RASGRP1 mRNA CTD PMID:19901195 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056
JBrowse link
G Rbbp7 RB binding protein 7, chromatin remodeling factor decreases expression ISO afimoxifene results in decreased expression of RBBP7 mRNA CTD PMID:16514628 NCBI chr  X:31,913,080...31,931,245
Ensembl chr  X:31,913,081...31,931,226
JBrowse link
G Rbks ribokinase decreases response to substance ISO RBKS results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 6:24,747,651...24,824,290
Ensembl chr 6:24,747,293...24,824,290
JBrowse link
G Rbm24 RNA binding motif protein 24 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of RBM24 mRNA] CTD PMID:21233418 NCBI chr17:18,275,681...18,288,231
Ensembl chr17:18,275,688...18,288,102
JBrowse link
G Rcl1 RNA terminal phosphate cyclase-like 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of RCL1 mRNA] CTD PMID:21233418 NCBI chr 1:226,824,524...226,869,046
Ensembl chr 1:226,824,534...226,902,315
JBrowse link
G Ret ret proto-oncogene multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of RET mRNA] CTD PMID:21233418 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression
multiple interactions
ISO afimoxifene results in increased expression of RGS16 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of RGS16 mRNA]
CTD PMID:19153601 NCBI chr13:65,887,788...65,891,232
Ensembl chr13:65,887,530...65,892,857
JBrowse link
G Rgs3 regulator of G-protein signaling 3 increases expression ISO afimoxifene results in increased expression of RGS3 mRNA CTD PMID:16849584 NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894
JBrowse link
G Rhbdf1 rhomboid 5 homolog 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RHBDF1 mRNA] CTD PMID:21233418 NCBI chr10:15,406,832...15,419,765
Ensembl chr10:15,406,859...15,419,763
JBrowse link
G Rhbdl2 rhomboid like 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RHBDL2 mRNA] CTD PMID:21233418 NCBI chr 5:136,037,489...136,086,542
Ensembl chr 5:136,037,305...136,081,969
JBrowse link
G Rhobtb1 Rho-related BTB domain containing 1 increases expression ISO afimoxifene results in increased expression of RHOBTB1 mRNA CTD PMID:19901195 NCBI chr20:19,327,142...19,456,121
Ensembl chr20:19,327,155...19,403,012
JBrowse link
G Rhot1 ras homolog family member T1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RHOT1 mRNA] CTD PMID:21233418 NCBI chr10:65,198,700...65,262,807
Ensembl chr10:65,170,560...65,262,804
JBrowse link
G Rnd1 Rho family GTPase 1 multiple interactions
increases expression
ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RND1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RND1 mRNA] CTD PMID:19153601 PMID:21233418 NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
JBrowse link
G Rnf114 ring finger protein 114 decreases expression ISO afimoxifene results in decreased expression of RNF114 mRNA CTD PMID:19698761 NCBI chr 3:156,222,487...156,234,263
Ensembl chr 3:156,222,498...156,234,256
JBrowse link
G Rpl6 ribosomal protein L6 decreases expression ISO afimoxifene results in decreased expression of RPL6 mRNA CTD PMID:16514628 NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
JBrowse link
G Rpp25 ribonuclease P and MRP subunit p25 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of RPP25 mRNA] CTD PMID:21233418 NCBI chr 8:57,907,352...57,908,732
Ensembl chr 8:57,907,352...57,908,732
JBrowse link
G Rps6ka6 ribosomal protein S6 kinase A6 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RPS6KA6 mRNA] CTD PMID:21233418 NCBI chr  X:76,354,824...76,454,484
Ensembl chr  X:76,353,760...76,454,484
JBrowse link
G Rps6kl1 ribosomal protein S6 kinase-like 1 decreases response to substance ISO RPS6KL1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 6:104,783,227...104,799,895
Ensembl chr 6:104,783,258...104,799,869
JBrowse link
G Rras2 RAS related 2 affects response to substance ISO RRAS2 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 decreases expression ISO afimoxifene results in decreased expression of RRM1 mRNA CTD PMID:16514628 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
JBrowse link
G Rrs1 ribosome biogenesis regulator 1 homolog multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of RRS1 mRNA] CTD PMID:21233418 NCBI chr 5:9,733,486...9,735,119
Ensembl chr 5:9,733,091...9,735,140
JBrowse link
G Rsph10b radial spoke head 10 homolog B multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RSPH10B mRNA] CTD PMID:21233418 NCBI chr12:10,627,434...10,675,227
Ensembl chr12:10,627,435...10,675,167
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of RXRA mRNA] CTD PMID:21233418 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Schip1 schwannomin interacting protein 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SCHIP1 mRNA] CTD PMID:21233418 NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585
JBrowse link
G Scyl3 SCY1 like pseudokinase 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SCYL3 mRNA] CTD PMID:21233418 NCBI chr13:76,278,428...76,303,038
Ensembl chr13:76,278,428...76,301,716
JBrowse link
G Sdc1 syndecan 1 increases expression ISO afimoxifene results in increased expression of SDC1 mRNA CTD PMID:16849584 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SDF2L1 mRNA] CTD PMID:21233418 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902
JBrowse link
G Sell selectin L increases expression ISO afimoxifene results in increased expression of SELL mRNA CTD PMID:19901195 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Sema3c semaphorin 3C increases expression ISO afimoxifene results in increased expression of SEMA3C mRNA CTD PMID:19901195 NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534
JBrowse link
G Serpina1 serpin family A member 1 increases expression ISO afimoxifene results in increased expression of SERPINA1 mRNA CTD PMID:16849584 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
JBrowse link
G Serpinb9 serpin family B member 9 increases expression
multiple interactions
ISO afimoxifene results in increased expression of SERPINB9 mRNA
ESR1 protein promotes the reaction [afimoxifene results in increased expression of SERPINB9 mRNA]
CTD PMID:14617632 PMID:17237823 NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230
JBrowse link
G Sesn1 sestrin 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SESN1 mRNA] CTD PMID:21233418 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
JBrowse link
G Sfpq splicing factor proline and glutamine rich decreases expression ISO afimoxifene results in decreased expression of SFPQ mRNA CTD PMID:16514628 NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472
JBrowse link
G Sfxn2 sideroflexin 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SFXN2 mRNA] CTD PMID:21233418 NCBI chr 1:245,447,014...245,459,312 JBrowse link
G Sgk3 serum/glucocorticoid regulated kinase family, member 3 decreases response to substance ISO SGK3 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 5:9,345,761...9,472,243
Ensembl chr 5:9,346,040...9,415,476
JBrowse link
G Sh3bp4 SH3-domain binding protein 4 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SH3BP4 mRNA] CTD PMID:21233418 NCBI chr 9:89,660,156...89,739,163
Ensembl chr 9:89,660,156...89,739,163
JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SH3RF1 mRNA] CTD PMID:21233418 NCBI chr16:28,735,522...28,901,690
Ensembl chr16:28,735,440...28,901,644
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 increases expression ISO afimoxifene results in increased expression of SHANK2 mRNA CTD PMID:16849584 NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394
JBrowse link
G Shb SH2 domain containing adaptor protein B increases expression ISO afimoxifene results in increased expression of SHB mRNA CTD PMID:12154049 NCBI chr 5:59,678,066...59,785,443
Ensembl chr 5:59,678,216...59,785,538
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO afimoxifene binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Shroom2 shroom family member 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SHROOM2 mRNA] CTD PMID:21233418 NCBI chr  X:21,812,469...21,983,724
Ensembl chr  X:21,812,469...21,984,153
JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SIAH2 mRNA] CTD PMID:21233418 NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO afimoxifene results in decreased expression of SLC10A1 mRNA CTD PMID:29285606 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases expression ISO afimoxifene results in decreased expression of SLC1A1 mRNA CTD PMID:19901195 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC22A5 mRNA] CTD PMID:21233418 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc25a1 solute carrier family 25 member 1 increases expression ISO afimoxifene results in increased expression of SLC25A1 mRNA CTD PMID:16849584 NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781
JBrowse link
G Slc25a15 solute carrier family 25 member 15 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC25A15 mRNA] CTD PMID:21233418 NCBI chr16:69,631,581...69,654,869
Ensembl chr16:69,634,414...69,653,010
JBrowse link
G Slc25a28 solute carrier family 25 member 28 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC25A28 mRNA] CTD PMID:21233418 NCBI chr 1:242,530,877...242,542,140
Ensembl chr 1:242,530,899...242,542,115
JBrowse link
G Slc26a2 solute carrier family 26 member 2 decreases expression
multiple interactions
ISO afimoxifene results in decreased expression of SLC26A2 mRNA
afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC26A2 mRNA]
CTD PMID:16514628 PMID:21233418 NCBI chr18:54,648,276...54,666,627
Ensembl chr18:54,652,951...54,666,626
JBrowse link
G Slc39a6 solute carrier family 39 member 6 decreases expression ISO afimoxifene results in decreased expression of SLC39A6 mRNA CTD PMID:16514628 NCBI chr18:15,864,874...15,885,417
Ensembl chr18:15,864,875...15,885,417
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC3A2 mRNA] CTD PMID:21233418 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO afimoxifene results in increased expression of SLC7A5 mRNA CTD PMID:19901195 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SLC9A1 mRNA] CTD PMID:21233418 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
JBrowse link
G Slit2 slit guidance ligand 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SLIT2 mRNA] CTD PMID:21233418 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948
JBrowse link
G Smc3 structural maintenance of chromosomes 3 affects response to substance ISO SMC3 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SMPD1 mRNA] CTD PMID:21233418 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
JBrowse link
G Smtn smoothelin multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SMTN mRNA] CTD PMID:21233418 NCBI chr14:78,398,595...78,420,908
Ensembl chr14:78,397,778...78,420,886
JBrowse link
G Snrpd1 small nuclear ribonucleoprotein D1 polypeptide multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SNRPD1 mRNA] CTD PMID:21233418 NCBI chr18:1,696,838...1,707,400
Ensembl chr18:1,696,852...1,708,256
JBrowse link
G Socs1 suppressor of cytokine signaling 1 multiple interactions
increases expression
ISO [afimoxifene co-treated with Cycloheximide] results in increased expression of SOCS1 mRNA; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of SOCS1 mRNA]; Estradiol inhibits the reaction [afimoxifene results in increased expression of SOCS1 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of SOCS1 mRNA] CTD PMID:16849584 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Socs2 suppressor of cytokine signaling 2 increases expression ISO afimoxifene results in increased expression of SOCS2 mRNA CTD PMID:23373633 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
JBrowse link
G Son SON DNA and RNA binding protein decreases expression ISO afimoxifene results in decreased expression of SON mRNA CTD PMID:16514628 NCBI chr11:30,850,890...30,923,167
Ensembl chr11:30,892,005...30,923,167
JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions
decreases expression
ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SOX9 mRNA]
afimoxifene results in decreased expression of SOX9 mRNA
CTD PMID:16849584 PMID:21233418 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Sphk1 sphingosine kinase 1 decreases response to substance ISO SPHK1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 decreases expression ISO afimoxifene results in decreased expression of SPTBN1 mRNA CTD PMID:19901195 NCBI chr14:103,842,684...104,008,507
Ensembl chr14:103,842,684...104,008,507
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 increases expression ISO afimoxifene results in increased expression of SRD5A1 mRNA CTD PMID:16849584 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
JBrowse link
G Srm spermidine synthase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SRM mRNA] CTD PMID:21233418 NCBI chr 5:159,025,919...159,029,076
Ensembl chr 5:159,025,873...159,029,405
JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 decreases expression ISO afimoxifene results in decreased expression of SRSF1 mRNA CTD PMID:16514628 NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336
JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of SRSF7 mRNA] CTD PMID:21233418 NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965
JBrowse link
G St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ST8SIA2 mRNA] CTD PMID:21233418 NCBI chr 1:127,766,669...127,838,017
Ensembl chr 1:127,762,573...127,838,091
JBrowse link
G St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ST8SIA4 mRNA] CTD PMID:21233418 NCBI chr 9:95,994,150...96,084,617
Ensembl chr 9:95,993,503...96,084,653
JBrowse link
G Stag1 stromal antigen 1 increases expression ISO afimoxifene results in increased expression of STAG1 mRNA CTD PMID:16849584 NCBI chr 8:101,179,039...101,564,684
Ensembl chr 8:101,179,039...101,564,677
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO afimoxifene results in decreased expression of STAT1 mRNA CTD PMID:16514628 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stc2 stanniocalcin 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of STC2 mRNA] CTD PMID:21233418 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Stk26 serine/threonine kinase 26 decreases expression ISO afimoxifene results in decreased expression of STK26 mRNA CTD PMID:16514628 NCBI chr  X:130,310,855...130,375,677
Ensembl chr  X:130,310,885...130,374,291
JBrowse link
G Stkld1 serine/threonine kinase-like domain containing 1 decreases response to substance ISO STKLD1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 3:10,261,583...10,280,850
Ensembl chr 3:10,261,828...10,280,566
JBrowse link
G Stmn1 stathmin 1 decreases expression ISO afimoxifene results in decreased expression of STMN1 mRNA CTD PMID:16514628 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Stom stomatin multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of STOM mRNA] CTD PMID:21233418 NCBI chr 3:18,645,058...18,667,343
Ensembl chr 3:18,644,378...18,667,354
JBrowse link
G Strada STE20 related adaptor alpha multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of STRADA mRNA] CTD PMID:21233418 NCBI chr10:91,094,849...91,123,890
Ensembl chr10:91,094,687...91,123,830
JBrowse link
G Sts steroid sulfatase decreases expression ISO afimoxifene results in decreased expression of STS mRNA CTD PMID:16849584 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 multiple interactions ISO afimoxifene inhibits the reaction [ESR1 protein binds to STUB1 protein] CTD PMID:16037132 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 affects response to substance
multiple interactions
increases metabolic processing
increases response to substance
increases sulfation
affects sulfation
ISO SULT1A1 protein affects the susceptibility to afimoxifene
[SULT1A1 3' UTR SNP affects the activity of SULT1A1 protein] which affects the metabolism of afimoxifene; [SULT1A1 protein results in increased metabolism of Tamoxifen] which results in increased abundance of afimoxifene
SULT1A1 protein results in increased metabolism of afimoxifene
SULT1A1 protein results in increased susceptibility to afimoxifene
SULT1A1 protein results in increased sulfation of afimoxifene
SULT1A1 gene polymorphism affects the sulfation of afimoxifene
CTD PMID:16517757 PMID:30120701 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Svil supervillin decreases expression ISO afimoxifene results in decreased expression of SVIL mRNA CTD PMID:19901195 NCBI chr17:52,648,502...52,844,114
Ensembl chr17:52,648,502...52,793,404
JBrowse link
G Sympk symplekin increases expression ISO afimoxifene results in increased expression of SYMPK mRNA CTD PMID:19698761 NCBI chr 1:78,672,326...78,700,684
Ensembl chr 1:78,672,378...78,700,684
JBrowse link
G Syt1 synaptotagmin 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of SYT1 mRNA] CTD PMID:21233418 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
JBrowse link
G Tacc1 transforming, acidic coiled-coil containing protein 1 decreases expression
multiple interactions
ISO afimoxifene results in decreased expression of TACC1 mRNA; afimoxifene results in decreased expression of TACC1 protein
afimoxifene inhibits the reaction [Estrogens results in decreased expression of TACC1 mRNA]
CTD PMID:15072547 PMID:18984771 PMID:21233418 NCBI chr16:66,812,232...66,895,736
Ensembl chr16:66,812,295...66,895,733
JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TACSTD2 mRNA] CTD PMID:21233418 NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650
JBrowse link
G Taf9 TATA-box binding protein associated factor 9 decreases expression ISO afimoxifene results in decreased expression of TAF9 mRNA CTD PMID:16514628 NCBI chr 2:31,794,316...31,798,324 JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases expression ISO afimoxifene results in decreased expression of TARS1 mRNA CTD PMID:16514628 NCBI chr 2:60,368,251...60,387,733
Ensembl chr 2:60,367,796...60,387,717
JBrowse link
G Tasor transcription activation suppressor increases expression ISO afimoxifene results in increased expression of TASOR mRNA CTD PMID:16849584 NCBI chr16:2,606,807...2,669,902
Ensembl chr16:2,603,936...2,667,292
JBrowse link
G Tatdn3 TatD DNase domain containing 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TATDN3 mRNA] CTD PMID:21233418 NCBI chr13:102,634,254...102,649,069 JBrowse link
G Tbx3 T-box transcription factor 3 multiple interactions ISO PD 173074 inhibits the reaction [afimoxifene results in increased expression of TBX3 protein] CTD PMID:21098263 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
JBrowse link
G Tceal1 transcription elongation factor A like 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TCEAL1 mRNA] CTD PMID:21233418 NCBI chr  X:100,058,485...100,060,439
Ensembl chr  X:100,058,132...100,060,551
JBrowse link
G Tcf7l2 transcription factor 7 like 2 increases expression ISO afimoxifene results in increased expression of TCF7L2 mRNA CTD PMID:19901195 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO afimoxifene results in increased expression of TFAM mRNA CTD PMID:22105178 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tfap2a transcription factor AP-2 alpha decreases expression ISO afimoxifene results in decreased expression of TFAP2A mRNA CTD PMID:19901195 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507
JBrowse link
G Tfap4 transcription factor AP-4 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TFAP4 mRNA] CTD PMID:21233418 NCBI chr10:11,001,338...11,019,386
Ensembl chr10:11,002,911...11,019,386
JBrowse link
G Tff1 trefoil factor 1 affects binding
increases expression
multiple interactions
decreases expression
ISO [afimoxifene binds to ESR1 protein] which binds to TFF1 protein
afimoxifene results in increased expression of TFF1 mRNA
afimoxifene inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; afimoxifene inhibits the reaction [Arsenic Trioxide results in increased expression of TFF1 mRNA]; afimoxifene inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]; afimoxifene inhibits the reaction [Estrogens results in increased expression of TFF1 mRNA]; afimoxifene promotes the reaction [ESR1 protein binds to TFF1 promoter]; afimoxifene promotes the reaction [GPS2 protein binds to TFF1 promoter]; afimoxifene promotes the reaction [HDAC3 protein binds to TFF1 promoter]; afimoxifene promotes the reaction [NCOR1 protein binds to TFF1 promoter]; methylselenic acid inhibits the reaction [afimoxifene results in increased expression of TFF1 mRNA]; SU 6656 inhibits the reaction [afimoxifene results in increased expression of TFF1 mRNA]
afimoxifene results in decreased expression of TFF1 mRNA
CTD PMID:14617632 PMID:15072547 PMID:15528270 PMID:16093440 PMID:16514628 More... NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TFRC mRNA] CTD PMID:21233418 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TGFB3 mRNA] CTD PMID:21233418 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Thbs2 thrombospondin 2 decreases expression ISO afimoxifene results in decreased expression of THBS2 mRNA CTD PMID:16514628 NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789
JBrowse link
G Timm23 translocase of inner mitochondrial membrane 23 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TIMM23 mRNA] CTD PMID:21233418 NCBI chr16:7,410,308...7,436,392
Ensembl chr16:7,409,688...7,436,379
JBrowse link
G Tipin timeless interacting protein multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TIPIN mRNA] CTD PMID:21233418 NCBI chr 8:64,780,741...64,801,355
Ensembl chr 8:64,780,828...64,801,352
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO afimoxifene results in increased expression of TLR2 mRNA CTD PMID:23373633 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tm4sf1 transmembrane 4 L six family member 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TM4SF1 mRNA] CTD PMID:21233418 NCBI chr 2:141,456,950...141,466,146
Ensembl chr 2:141,453,310...141,466,146
JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 increases expression ISO afimoxifene results in increased expression of TM7SF2 mRNA CTD PMID:16849584 NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270
JBrowse link
G Tmed8 transmembrane p24 trafficking protein family member 8 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TMED8 mRNA] CTD PMID:21233418 NCBI chr 6:106,806,973...106,841,271 JBrowse link
G Tmeff1 transmembrane protein with EGF-like and two follistatin-like domains 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TMEFF1 mRNA] CTD PMID:21233418 NCBI chr 5:62,910,740...62,996,494
Ensembl chr 5:62,910,740...62,996,493
JBrowse link
G Tmpo thymopoietin decreases expression ISO afimoxifene results in decreased expression of TMPO mRNA CTD PMID:16514628 NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727
JBrowse link
G Tmprss2 transmembrane serine protease 2 affects response to substance ISO TMPRSS2 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of TNF mRNA] CTD PMID:19153601 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of TNFAIP3 mRNA] CTD PMID:19153601 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tnpo1 transportin 1 decreases expression ISO afimoxifene results in decreased expression of TNPO1 mRNA CTD PMID:16514628 NCBI chr 2:30,207,529...30,300,162
Ensembl chr 2:30,211,510...30,300,375
JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TOMM40 mRNA] CTD PMID:21233418 NCBI chr 1:79,358,781...79,370,976
Ensembl chr 1:79,358,786...79,370,915
JBrowse link
G Top1 DNA topoisomerase I decreases expression ISO afimoxifene results in decreased expression of TOP1 mRNA CTD PMID:16514628 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2b DNA topoisomerase II beta decreases expression ISO afimoxifene results in decreased expression of TOP2B mRNA CTD PMID:16514628 NCBI chr15:9,051,661...9,111,220
Ensembl chr15:9,051,341...9,112,085
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TP53INP1 mRNA] CTD PMID:21233418 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
JBrowse link
G Tp53rk TP53 regulating kinase decreases response to substance ISO TP53RK results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 3:155,529,298...155,532,662
Ensembl chr 3:155,529,298...155,532,728
JBrowse link
G Tp63 tumor protein p63 increases expression ISO afimoxifene results in increased expression of TP63 mRNA CTD PMID:23373633 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link
G Tpbg trophoblast glycoprotein multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TPBG mRNA] CTD PMID:21233418 NCBI chr 8:86,793,953...86,797,324
Ensembl chr 8:86,793,749...86,797,741
JBrowse link
G Tpd52l1 TPD52 like 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TPD52L1 mRNA] CTD PMID:21233418 NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109
JBrowse link
G Tpm4 tropomyosin 4 affects response to substance ISO TPM4 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984
JBrowse link
G Trak2 trafficking kinesin protein 2 decreases expression ISO afimoxifene results in decreased expression of TRAK2 mRNA CTD PMID:16514628 NCBI chr 9:60,348,531...60,414,036
Ensembl chr 9:60,350,012...60,413,996
JBrowse link
G Trerf1 transcriptional regulating factor 1 decreases response to substance ISO TRERF1 protein results in decreased susceptibility to afimoxifene CTD PMID:18351453 NCBI chr 9:13,631,619...13,858,326
Ensembl chr 9:13,634,126...13,857,029
JBrowse link
G Trib1 tribbles pseudokinase 1 decreases response to substance ISO TRIB1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
JBrowse link
G Trim25 tripartite motif-containing 25 multiple interactions
increases expression
ISO afimoxifene inhibits the reaction [Estradiol results in increased expression of TRIM25 mRNA]; afimoxifene inhibits the reaction [Estradiol results in increased expression of TRIM25 protein]
afimoxifene results in increased expression of TRIM25 mRNA; afimoxifene results in increased expression of TRIM25 protein
CTD PMID:19148513 NCBI chr10:73,812,818...73,831,271
Ensembl chr10:73,812,818...73,831,257
JBrowse link
G Trmt1 tRNA methyltransferase 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TRMT1 mRNA] CTD PMID:21233418 NCBI chr19:23,456,756...23,471,581
Ensembl chr19:23,456,756...23,466,956
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TSC22D1 mRNA] CTD PMID:21233418 NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958
JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TSKU mRNA] CTD PMID:21233418 NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588
JBrowse link
G Tspyl5 TSPY-like 5 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of TSPYL5 mRNA] CTD PMID:21233418 NCBI chr 7:64,881,092...64,885,538
Ensembl chr 7:64,884,225...64,885,457
JBrowse link
G Tuft1 tuftelin 1 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of TUFT1 mRNA] CTD PMID:19153601 NCBI chr 2:182,259,457...182,306,296
Ensembl chr 2:182,260,398...182,306,192
JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of TWIST1 mRNA] CTD PMID:21233418 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression ISO afimoxifene results in decreased expression of TXNRD1 mRNA CTD PMID:16514628 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Uba3 ubiquitin-like modifier activating enzyme 3 affects response to substance ISO UBA3 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr 4:129,789,526...129,810,707
Ensembl chr 4:129,789,204...129,810,606
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases expression ISO afimoxifene results in decreased expression of UGT1A1 mRNA CTD PMID:15072547 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ulk4 unc-51 like kinase 4 decreases response to substance ISO ULK4 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 8:120,670,879...120,966,026
Ensembl chr 8:120,670,866...120,966,924
JBrowse link
G Umps uridine monophosphate synthetase multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of UMPS mRNA] CTD PMID:21233418 NCBI chr11:66,806,107...66,816,520
Ensembl chr11:66,806,045...66,821,903
JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO afimoxifene results in decreased expression of UNG mRNA CTD PMID:16514628 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase increases expression ISO afimoxifene results in increased expression of UPF1 mRNA CTD PMID:16849584 NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568
JBrowse link
G Usp32 ubiquitin specific peptidase 32 decreases expression ISO afimoxifene results in decreased expression of USP32 mRNA CTD PMID:16514628 NCBI chr10:69,855,885...70,029,075
Ensembl chr10:69,855,885...70,029,137
JBrowse link
G Vdr vitamin D receptor decreases expression ISO afimoxifene results in decreased expression of VDR protein CTD PMID:8593782 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases secretion
increases expression
ISO afimoxifene inhibits the reaction [Estradiol results in increased expression of VEGFA mRNA]; afimoxifene inhibits the reaction [Estradiol results in increased expression of VEGFA protein]
afimoxifene results in increased secretion of VEGFA protein
afimoxifene results in increased expression of VEGFA mRNA; afimoxifene results in increased expression of VEGFA protein
CTD PMID:19148513 PMID:19828145 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vipr1 vasoactive intestinal peptide receptor 1 increases expression ISO afimoxifene results in increased expression of VIPR1 mRNA CTD PMID:19901195 NCBI chr 8:121,303,739...121,339,587 JBrowse link
G Vrk3 VRK serine/threonine kinase 3 decreases response to substance ISO VRK3 results in decreased susceptibility to afimoxifene CTD PMID:21233418 NCBI chr 1:95,243,344...95,270,780
Ensembl chr 1:95,243,364...95,270,780
JBrowse link
G Vstm4 V-set and transmembrane domain containing 4 affects response to substance ISO VSTM4 gene affects the susceptibility to afimoxifene CTD PMID:21482774 NCBI chr16:8,120,336...8,200,272
Ensembl chr16:8,120,336...8,200,269
JBrowse link
G Vtn vitronectin multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of VTN mRNA] CTD PMID:21233418 NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810
JBrowse link
G Wdr4 WD repeat domain 4 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of WDR4 mRNA] CTD PMID:21233418 NCBI chr20:9,587,205...9,611,434
Ensembl chr20:9,587,207...9,603,581
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of WFS1 mRNA] CTD PMID:21233418 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
JBrowse link
G Wnt2 Wnt family member 2 increases expression ISO afimoxifene results in increased expression of WNT2 mRNA CTD PMID:15072547 NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402
JBrowse link
G Wnt4 Wnt family member 4 increases expression ISO afimoxifene results in increased expression of WNT4 mRNA CTD PMID:16849584 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859
JBrowse link
G Wwc1 WW and C2 domain containing 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of WWC1 mRNA] CTD PMID:21233418 NCBI chr10:20,300,735...20,454,393
Ensembl chr10:20,300,833...20,454,497
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of XBP1 mRNA] CTD PMID:21233418 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Xpo1 exportin 1 decreases expression ISO afimoxifene results in decreased expression of XPO1 mRNA CTD PMID:16514628 NCBI chr14:97,233,263...97,275,536
Ensembl chr14:97,233,270...97,275,498
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression ISO afimoxifene results in decreased expression of XRCC5 mRNA CTD PMID:16514628 NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018
JBrowse link
G Yrdc yrdC N(6)-threonylcarbamoyltransferase domain containing multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of YRDC mRNA] CTD PMID:21233418 NCBI chr 5:137,110,244...137,115,127
Ensembl chr 5:137,110,279...137,115,120
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta increases expression ISO afimoxifene results in increased expression of YWHAZ mRNA CTD PMID:16849584 NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO afimoxifene results in increased expression of ZEB1 mRNA CTD PMID:12154049 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
JBrowse link
G Zfp148 zinc finger protein 148 increases expression ISO afimoxifene results in increased expression of ZNF148 mRNA CTD PMID:12154049 NCBI chr11:67,276,455...67,385,803
Ensembl chr11:67,281,707...67,385,772
JBrowse link
G Zfp185 zinc finger protein 185 increases expression ISO afimoxifene results in increased expression of ZNF185 mRNA CTD PMID:16849584 NCBI chr  X:150,831,869...150,877,652
Ensembl chr  X:150,831,862...150,874,810
JBrowse link
G Zfp217 zinc finger protein 217 decreases expression ISO afimoxifene results in decreased expression of ZNF217 mRNA CTD PMID:15072547 NCBI chr 3:158,890,464...158,931,148
Ensembl chr 3:158,892,265...158,913,040
JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions
increases expression
ISO GPER1 protein affects the reaction [afimoxifene results in increased expression of ZFP36 mRNA] CTD PMID:19153601 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
JBrowse link
G Zfp467 zinc finger protein 467 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ZNF467 mRNA] CTD PMID:21233418 NCBI chr 4:77,385,752...77,394,709
Ensembl chr 4:77,385,758...77,392,229
JBrowse link
G Zfp703 zinc finger protein 703 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in increased expression of ZNF703 mRNA] CTD PMID:21233418 NCBI chr16:65,076,507...65,080,677
Ensembl chr16:65,076,507...65,080,677
JBrowse link
G Zfp704 zinc finger protein 704 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ZNF704 mRNA] CTD PMID:21233418 NCBI chr 2:92,171,804...92,356,059
Ensembl chr 2:92,171,496...92,351,282
JBrowse link
G Zfp821 zinc finger protein 821 multiple interactions ISO afimoxifene inhibits the reaction [Estrogens results in decreased expression of ZNF821 mRNA] CTD PMID:21233418 NCBI chr19:37,679,937...37,698,831
Ensembl chr19:37,680,628...37,698,831
JBrowse link
G Zwint ZW10 interacting kinetochore protein decreases expression ISO afimoxifene results in decreased expression of ZWINT mRNA CTD PMID:19698761 NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            afimoxifene 596
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        tertiary amino compound 8677
                                          tamoxifen 3244
                                            afimoxifene 596
paths to the root