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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:all-trans-4-oxoretinol
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Accession:CHEBI:44597 term browser browse the term
Definition:A retinoid that is all-trans-retinol in which the hydrogens at position 4 have been replaced by an oxo group.
Synonyms:related_synonym: 4-ketoretinol;   4-oxo-ROL;   4-oxoretinol;   Formula=C20H28O2;   InChI=1S/C20H28O2/c1-15(7-6-8-16(2)12-14-21)9-10-18-17(3)19(22)11-13-20(18,4)5/h6-10,12,21H,11,13-14H2,1-5H3/b8-6+,10-9+,15-7+,16-12+;   InChIKey=PLIUCYCUYQIBDZ-RMWYGNQTSA-N;   SMILES=C1(=C(C(CCC1(C)C)=O)C)/C=C/C(=C/C=C/C(=C/CO)/C)/C
 xref: CAS:62702-55-0;   DrugBank:DB02699;   HMDB:HMDB0012329;   KEGG:C16683
 xref_mesh: MESH:C041819
 xref: PDBeChem:OXR;   PMID:10415093;   PMID:10557354;   PMID:15817863;   PMID:17943179;   PMID:18006143;   PMID:19492420;   PMID:24662164;   PMID:8643497;   PMID:9377581;   PMID:9581846;   Patent:US6150421;   Reaxys:14831438


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all-trans-4-oxoretinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh1 cadherin 1 affects expression ISO 4-oxoretinol affects the expression of CDH1 mRNA CTD PMID:17034753 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO 4-oxoretinol results in increased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col4a2 collagen type IV alpha 2 chain increases expression ISO 4-oxoretinol results in increased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr16:83,386,388...83,522,169
Ensembl chr16:83,387,364...83,438,561
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 increases expression ISO 4-oxoretinol results in increased expression of CRABP2 mRNA CTD PMID:17034753 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 affects chemical synthesis ISO CYP26A1 protein affects the chemical synthesis of 4-oxoretinol CTD PMID:10557354 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO 4-oxoretinol results in decreased expression of FAS mRNA CTD PMID:17034753 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Foxa1 forkhead box A1 increases expression ISO 4-oxoretinol results in increased expression of FOXA1 mRNA CTD PMID:17034753 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO 4-oxoretinol results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO 4-oxoretinol results in increased expression of ITGAM protein CTD PMID:9581846 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Ivl involucrin increases expression ISO 4-oxoretinol results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577
JBrowse link
G Krt18 keratin 18 increases expression ISO 4-oxoretinol results in increased expression of KRT18 mRNA CTD PMID:17034753 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt19 keratin 19 increases expression ISO 4-oxoretinol results in increased expression of KRT19 mRNA CTD PMID:17034753 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Krt7 keratin 7 increases expression ISO 4-oxoretinol results in increased expression of KRT7 mRNA CTD PMID:17034753 NCBI chr 7:143,059,731...143,075,907
Ensembl chr 7:143,059,764...143,075,907
JBrowse link
G Krt8 keratin 8 increases expression ISO 4-oxoretinol results in increased expression of KRT8 mRNA CTD PMID:17034753 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO 4-oxoretinol results in decreased expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Meis1 Meis homeobox 1 increases expression ISO 4-oxoretinol results in increased expression of MEIS1 mRNA CTD PMID:17034753 NCBI chr14:103,182,178...103,321,809
Ensembl chr14:103,181,281...103,321,270
JBrowse link
G Meis2 Meis homeobox 2 increases expression ISO 4-oxoretinol results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr 3:107,560,172...107,762,732
Ensembl chr 3:107,559,997...107,760,589
JBrowse link
G Meox1 mesenchyme homeobox 1 increases expression ISO 4-oxoretinol results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression ISO 4-oxoretinol results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO 4-oxoretinol results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Rara retinoic acid receptor, alpha increases expression ISO 4-oxoretinol results in increased expression of RARA mRNA CTD PMID:17034753 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression ISO 4-oxoretinol results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 2:164,650,722...164,684,982
Ensembl chr 2:164,650,722...164,684,985
JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO 4-oxoretinol results in increased expression of TGM2 mRNA CTD PMID:17034753 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        pharmaceutical 19293
          drug 19293
            antineoplastic agent 17004
              all-trans-4-oxoretinol 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            organic hydride 18265
                              organic fundamental parent 18265
                                hydrocarbon 17986
                                  terpene 9609
                                    diterpene 8430
                                      diterpenoid 8430
                                        retinoid 7854
                                          retinol 283
                                            all-trans-retinol 282
                                              all-trans-4-oxoretinol 23
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