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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:desogestrel
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Accession:CHEBI:4453 term browser browse the term
Definition:A terminal acetylenic compound that has formula C22H30O.
Synonyms:exact_synonym: 17alpha-ethynyl-11-methylidene-18a-homo-estr-4-en-17beta-ol
 related_synonym: 13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol;   Cerazette;   Formula=C22H30O;   InChI=1S/C22H30O/c1-4-21-14-15(3)20-17-9-7-6-8-16(17)10-11-18(20)19(21)12-13-22(21,23)5-2/h2,8,17-20,23H,3-4,6-7,9-14H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1;   InChIKey=RPLCPCMSCLEKRS-BPIQYHPVSA-N;   SMILES=[H][C@]12CCCC=C1CC[C@@]1([H])[C@]3([H])CC[C@@](O)(C#C)[C@@]3(CC)CC(=C)[C@]21[H];   desogestrelum
 xref: Beilstein:5094648;   CAS:54024-22-5;   DrugBank:DB00304;   Drug_Central:818;   KEGG:C07629;   KEGG:D02367;   LIPID_MAPS_instance:LMST02030104
 xref_mesh: MESH:D017135
 xref: Patent:DE2361120;   Patent:US3927046;   Wikipedia:Desogestrel



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desogestrel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Desogestrel results in decreased activity of AKR1C3 protein CTD PMID:21182831 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of APOE mRNA CTD PMID:18160741 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Cat catalase multiple interactions ISO [Ethinyl Estradiol co-treated with Desogestrel] results in decreased activity of CAT protein CTD PMID:17541152 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccn5 cellular communication network factor 5 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CCN5 mRNA CTD PMID:18160741 NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636
JBrowse link
G Cpb2 carboxypeptidase B2 increases activity ISO Desogestrel results in increased activity of CPB2 protein CTD PMID:11301170 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556
JBrowse link
G Crp C-reactive protein multiple interactions ISO [Ethinyl Estradiol co-treated with Desogestrel] results in increased expression of CRP protein; Simvastatin inhibits the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in increased expression of CRP protein] CTD PMID:17105841 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cst9l cystatin 9-like multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of CST9L mRNA CTD PMID:18160741 NCBI chr 3:136,288,093...136,290,906
Ensembl chr 3:136,288,093...136,290,906
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP11A1 mRNA CTD PMID:18160741 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP17A1 mRNA CTD PMID:18160741 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Desogestrel results in decreased activity of CYP1A2 protein CTD PMID:18816299 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of DDR1 mRNA CTD PMID:18160741 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of DHCR24 mRNA CTD PMID:18160741 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Dpep3 dipeptidase 3 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of DPEP3 mRNA CTD PMID:18160741 NCBI chr19:33,868,229...33,876,609
Ensembl chr19:33,868,242...33,873,896
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of HMGCS2 mRNA CTD PMID:18160741 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Insl3 insulin-like 3 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of INSL3 mRNA CTD PMID:18160741 NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression
ISO [Desogestrel co-treated with Ethinyl Estradiol] results in increased expression of LDLR protein
Desogestrel results in increased expression of LDLR protein
CTD PMID:17900441 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO [Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of LHB protein; Simvastatin promotes the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of LHB protein] CTD PMID:17105841 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,898,267...95,901,963
Ensembl chr 1:95,898,267...95,901,963
JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PAPSS2 mRNA CTD PMID:18160741 NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Desogestrel binds to and affects the activity of PGR protein CTD PMID:15697108 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PGRMC1 mRNA CTD PMID:18160741 NCBI chr  X:115,832,865...115,841,060
Ensembl chr  X:115,832,884...115,888,682
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Desogestrel] affects the activity of PON1 protein CTD PMID:17541152 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa decreases activity ISO Desogestrel results in decreased activity of PROC protein CTD PMID:11301170 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Prok1 prokineticin 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PROK1 mRNA CTD PMID:18160741 NCBI chr 2:194,853,991...194,859,250
Ensembl chr 2:194,853,991...194,859,250
JBrowse link
G Pros1 protein S affects expression ISO Desogestrel affects the expression of PROS1 protein CTD PMID:11442481 NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286
JBrowse link
G Rhob ras homolog family member B multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of RHOB mRNA CTD PMID:18160741 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Sycp1 synaptonemal complex protein 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of SYCP1 mRNA CTD PMID:18160741 NCBI chr 2:190,296,688...190,456,687
Ensembl chr 2:190,296,954...190,456,737
JBrowse link
G Taf4b TATA-box binding protein associated factor 4b multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of TAF4B mRNA CTD PMID:18160741 NCBI chr18:5,952,737...6,086,408
Ensembl chr18:5,952,769...6,068,307
JBrowse link
G Tex19.2 testis expressed gene 19.2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of TEX19 mRNA CTD PMID:18160741 NCBI chr10:106,379,757...106,382,344
Ensembl chr10:106,379,757...106,382,344
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of VCAM1 protein; Simvastatin promotes the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of VCAM1 protein] CTD PMID:17105841 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

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  CHEBI ontology 20059
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                  main group element atom 19956
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                      carbon group element atom 19882
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                                  steroid 13379
                                    hydroxy steroid 13008
                                      17-hydroxy steroid 12554
                                        17beta-hydroxy steroid 11419
                                          desogestrel 29
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