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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-ethylmaleimide
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Accession:CHEBI:44485 term browser browse the term
Definition:A member of the class of maleimides that is the N-ethyl derivative of maleimide.
Synonyms:related_synonym: 1-ethyl-1H-pyrrole-2,5-dione;   Ethylmaleimide;   Formula=C6H7NO2;   InChI=1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3;   InChIKey=HDFGOPSGAURCEO-UHFFFAOYSA-N;   NEM;   SMILES=CCN1C(=O)C=CC1=O
 alt_id: CHEBI:44483;   CHEBI:7269
 xref: Beilstein:112448;   CAS:128-53-0;   DrugBank:DB02967;   Gmelin:405614;   KEGG:C02441;   LINCS:LSM-4219
 xref_mesh: MESH:D005033
 xref: MetaCyc:N-ETHYLMALEIMIDE;   PDBeChem:NEQ;   PMID:12232209;   PMID:18499511;   PMID:24211707;   PMID:6501266;   Reaxys:112448;   Wikipedia:N-Ethylmaleimide


show annotations for term's descendants           Sort by:
N-ethylmaleimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases activity EXP Ethylmaleimide results in decreased activity of ABCB1 protein CTD PMID:2900677 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) affects activity
multiple interactions		 EXP Ethylmaleimide affects the activity of ABCC1 protein
Ethylmaleimide inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]		 CTD PMID:9096673 PMID:9334814 PMID:16101123 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ALB albumin decreases transport ISO Ethylmaleimide results in decreased transport of ALB protein CTD PMID:15897811 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions EXP Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772 		JBrowse link
G ATP7A ATPase copper transporting alpha multiple interactions
increases glutathionylation		 EXP Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,690...78,050,395 		JBrowse link
G ATP8B1 ATPase phospholipid transporting 8B1 multiple interactions ISO Ethylmaleimide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines] CTD PMID:11584374 NCBI chr18:57,646,426...57,803,315
Ensembl chr18:57,646,426...57,803,315 		JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions EXP Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971 		JBrowse link
G CHAT choline O-acetyltransferase decreases activity ISO Ethylmaleimide results in decreased activity of CHAT protein CTD PMID:3437937 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Ethylmaleimide inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein] CTD PMID:10820281 NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G DUSP23 dual specificity phosphatase 23 multiple interactions EXP Ethylmaleimide inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] CTD PMID:15147733 NCBI chr 1:159,780,962...159,782,543
Ensembl chr 1:159,780,932...159,782,543 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP Ethylmaleimide results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759 		JBrowse link
G GAD1 glutamate decarboxylase 1 decreases activity EXP Ethylmaleimide results in decreased activity of GAD1 protein CTD PMID:15836621 NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151 		JBrowse link
G GAD2 glutamate decarboxylase 2 decreases activity EXP Ethylmaleimide results in decreased activity of GAD2 protein CTD PMID:15836621 NCBI chr10:26,216,372...26,304,558
Ensembl chr10:26,216,665...26,304,558 		JBrowse link
G HOXB13 homeobox B13 increases response to substance EXP HOXB13 protein results in increased susceptibility to Ethylmaleimide CTD PMID:24213000 NCBI chr17:48,724,763...48,728,750
Ensembl chr17:48,724,763...48,728,750 		JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions EXP Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein] CTD PMID:22796344 NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553 		JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G LTBR lymphotoxin beta receptor multiple interactions EXP Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] CTD PMID:37193757 NCBI chr12:6,375,160...6,391,566
Ensembl chr12:6,375,045...6,391,571 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MT3 metallothionein 3 increases alkylation EXP Ethylmaleimide results in increased alkylation of MT3 protein CTD PMID:12383939 NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088 		JBrowse link
G OSM oncostatin M multiple interactions EXP Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] CTD PMID:37193757 NCBI chr22:30,262,829...30,266,851
Ensembl chr22:30,262,829...30,266,851 		JBrowse link
G PAH phenylalanine hydroxylase multiple interactions ISO Ethylmaleimide results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein] CTD PMID:19367645 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410 		JBrowse link
G SENP1 SUMO specific peptidase 1 multiple interactions EXP Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein] CTD PMID:26060329 NCBI chr12:48,042,897...48,106,079
Ensembl chr12:48,039,784...48,106,079 		JBrowse link
G SENP6 SUMO specific peptidase 6 multiple interactions EXP Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr 6:75,601,880...75,718,281
Ensembl chr 6:75,601,509...75,718,281 		JBrowse link
G SLC12A5 solute carrier family 12 member 5 increases activity
multiple interactions		 EXP Ethylmaleimide results in increased activity of SLC12A5 protein
Ethylmaleimide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]		 CTD PMID:20086212 NCBI chr20:46,021,686...46,060,150
Ensembl chr20:46,021,690...46,060,150 		JBrowse link
G SLC16A1 solute carrier family 16 member 1 multiple interactions EXP Ethylmaleimide inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SP1 Sp1 transcription factor multiple interactions ISO
EXP		 Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] CTD PMID:9343396 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446 		JBrowse link
G SUMO2 small ubiquitin like modifier 2 multiple interactions EXP Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]; Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr17:75,165,586...75,182,959
Ensembl chr17:75,165,586...75,182,959 		JBrowse link
G TF transferrin decreases uptake ISO Ethylmaleimide results in decreased uptake of TF protein CTD PMID:10865941 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641 		JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein] CTD PMID:15983997 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G VDAC1 voltage dependent anion channel 1 affects binding ISO Ethylmaleimide binds to VDAC1 protein CTD PMID:20192921 NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      biological role 25936
        antimicrobial agent 21902
          antiviral agent 11727
            anticoronaviral agent 10273
              N-ethylmaleimide 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            heteroorganic entity 24773
                              organochalcogen compound 24384
                                organooxygen compound 24061
                                  carbonyl compound 23569
                                    dicarboxylic acids and O-substituted derivatives 11540
                                      dicarboxylic acid 11534
                                        C4-dicarboxylic acid 1409
                                          butenedioic acid 625
                                            maleic acid 590
                                              maleimides 167
                                                maleimide 84
                                                  N-ethylmaleimide 32
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