CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: N-ethylmaleimide
Accession: CHEBI:44485
browse the term
Definition: A member of the class of maleimides that is the N-ethyl derivative of maleimide.
Synonyms: related_synonym: 1-ethyl-1H-pyrrole-2,5-dione; Ethylmaleimide; Formula=C6H7NO2; InChI=1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3; InChIKey=HDFGOPSGAURCEO-UHFFFAOYSA-N; NEM; SMILES=CCN1C(=O)C=CC1=O
alt_id: CHEBI:44483; CHEBI:7269
xref: Beilstein:112448; CAS:128-53-0; DrugBank:DB02967; Gmelin:405614; KEGG:C02441; LINCS:LSM-4219
xref_mesh: MESH:D005033
xref: MetaCyc:N-ETHYLMALEIMIDE; PDBeChem:NEQ; PMID:12232209; PMID:18499511; PMID:24211707; PMID:6501266; Reaxys:112448; Wikipedia:N-Ethylmaleimide
G
ABCB1
ATP binding cassette subfamily B member 1
decreases activity
EXP
Ethylmaleimide results in decreased activity of ABCB1 protein
CTD
PMID:2900677
NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
G
ABCC1
ATP binding cassette subfamily C member 1 (ABCC1 blood group)
affects activity multiple interactions
EXP
Ethylmaleimide affects the activity of ABCC1 protein Ethylmaleimide inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
CTD
PMID:9096673 PMID:9334814 PMID:16101123
NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
G
ALB
albumin
decreases transport
ISO
Ethylmaleimide results in decreased transport of ALB protein
CTD
PMID:15897811
NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
G
APEX1
apurinic/apyrimidinic endodeoxyribonuclease 1
multiple interactions
EXP
Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]]
CTD
PMID:23370007
NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772
G
ATP7A
ATPase copper transporting alpha
multiple interactions increases glutathionylation
EXP
Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein]
CTD
PMID:20566629
NCBI chr X:77,910,693...78,050,395
Ensembl chr X:77,910,690...78,050,395
G
ATP8B1
ATPase phospholipid transporting 8B1
multiple interactions
ISO
Ethylmaleimide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines]
CTD
PMID:11584374
NCBI chr18:57,646,426...57,803,315
Ensembl chr18:57,646,426...57,803,315
G
CFTR
CF transmembrane conductance regulator
multiple interactions
EXP
Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein]
CTD
PMID:15657297
NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
G
CHAT
choline O-acetyltransferase
decreases activity
ISO
Ethylmaleimide results in decreased activity of CHAT protein
CTD
PMID:3437937
NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
G
CHUK
component of inhibitor of nuclear factor kappa B kinase complex
multiple interactions
ISO
Ethylmaleimide inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]
CTD
PMID:10820281
NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596
G
DUSP23
dual specificity phosphatase 23
multiple interactions
EXP
Ethylmaleimide inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate]
CTD
PMID:15147733
NCBI chr 1:159,780,962...159,782,543
Ensembl chr 1:159,780,932...159,782,543
G
F3
coagulation factor III, tissue factor
increases expression
EXP
Ethylmaleimide results in increased expression of F3 protein
CTD
PMID:25569083
NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
G
GAD1
glutamate decarboxylase 1
decreases activity
EXP
Ethylmaleimide results in decreased activity of GAD1 protein
CTD
PMID:15836621
NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
G
GAD2
glutamate decarboxylase 2
decreases activity
EXP
Ethylmaleimide results in decreased activity of GAD2 protein
CTD
PMID:15836621
NCBI chr10:26,216,372...26,304,558
Ensembl chr10:26,216,665...26,304,558
G
HOXB13
homeobox B13
increases response to substance
EXP
HOXB13 protein results in increased susceptibility to Ethylmaleimide
CTD
PMID:24213000
NCBI chr17:48,724,763...48,728,750
Ensembl chr17:48,724,763...48,728,750
G
HSD11B2
hydroxysteroid 11-beta dehydrogenase 2
multiple interactions
EXP
Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein]
CTD
PMID:22796344
NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553
G
IL1A
interleukin 1 alpha
multiple interactions
EXP
Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]
CTD
PMID:7476933
NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
G
LTBR
lymphotoxin beta receptor
multiple interactions
EXP
Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein]
CTD
PMID:37193757
NCBI chr12:6,375,160...6,391,566
Ensembl chr12:6,375,045...6,391,571
G
MAPK1
mitogen-activated protein kinase 1
multiple interactions
EXP
Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]]
CTD
PMID:23370007
NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
G
MT3
metallothionein 3
increases alkylation
EXP
Ethylmaleimide results in increased alkylation of MT3 protein
CTD
PMID:12383939
NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088
G
OSM
oncostatin M
multiple interactions
EXP
Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein]
CTD
PMID:37193757
NCBI chr22:30,262,829...30,266,851
Ensembl chr22:30,262,829...30,266,851
G
PAH
phenylalanine hydroxylase
multiple interactions
ISO
Ethylmaleimide results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein]
CTD
PMID:19367645
NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
G
SENP1
SUMO specific peptidase 1
multiple interactions
EXP
Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]
CTD
PMID:26060329
NCBI chr12:48,042,897...48,106,079
Ensembl chr12:48,039,784...48,106,079
G
SENP6
SUMO specific peptidase 6
multiple interactions
EXP
Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein]
CTD
PMID:26060329
NCBI chr 6:75,601,880...75,718,281
Ensembl chr 6:75,601,509...75,718,281
G
SLC12A5
solute carrier family 12 member 5
increases activity multiple interactions
EXP
Ethylmaleimide results in increased activity of SLC12A5 protein Ethylmaleimide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]
CTD
PMID:20086212
NCBI chr20:46,021,686...46,060,150
Ensembl chr20:46,021,690...46,060,150
G
SLC16A1
solute carrier family 16 member 1
multiple interactions
EXP
Ethylmaleimide inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]
CTD
PMID:15804185
NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593
G
SOD2
superoxide dismutase 2
multiple interactions
EXP
Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein]
CTD
PMID:7476933
NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
G
SP1
Sp1 transcription factor
multiple interactions
ISO EXP
Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]
CTD
PMID:9343396
NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
G
SUMO2
small ubiquitin like modifier 2
multiple interactions
EXP
Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]; Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein]
CTD
PMID:26060329
NCBI chr17:75,165,586...75,182,959
Ensembl chr17:75,165,586...75,182,959
G
TF
transferrin
decreases uptake
ISO
Ethylmaleimide results in decreased uptake of TF protein
CTD
PMID:10865941
NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641
G
TH
tyrosine hydroxylase
multiple interactions
ISO
Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]
CTD
PMID:15983997
NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815
G
TNF
tumor necrosis factor
multiple interactions
EXP
Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein]
CTD
PMID:7476933
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
G
VDAC1
voltage dependent anion channel 1
affects binding
ISO
Ethylmaleimide binds to VDAC1 protein
CTD
PMID:20192921
NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all