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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxyurea
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Accession:CHEBI:44423 term browser browse the term
Definition:A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.
Synonyms:related_synonym: Formula=CH4N2O2;   Hydroxycarbamid;   Hydroxycarbamide;   Hydroxyharnstoff;   InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4);   InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N;   N-HYDROXYUREA;   N-carbamoylhydroxylamine;   SMILES=NC(=O)NO;   carbamohydroxamic acid;   carbamohydroximic acid;   carbamoyl oxime;   carbamyl hydroxamate;   hidroxicarbamida;   hydrea;   hydroxycarbamidum;   oxyurea
 alt_id: CHEBI:44420;   CHEBI:5816
 xref: Beilstein:1741548;   CAS:127-07-1;   DrugBank:DB01005;   Drug_Central:1399;   Gmelin:130423;   HMDB:HMDB0015140;   KEGG:C07044;   KEGG:D00341
 xref_mesh: MESH:D006918
 xref: MetaCyc:HYDROXY-UREA;   PDBeChem:NHY;   PMID:11285159;   PMID:11298103;   PMID:11364534;   PMID:11365149;   PMID:11391710;   PMID:12107454;   PMID:14988684;   PMID:15772364;   PMID:15994344;   PMID:16356682;   PMID:22983419;   PMID:23318979;   PMID:23643402;   PMID:23696560;   PMID:9271088;   Patent:US2705727;   Reaxys:1741548;   Wikipedia:Hydroxyurea


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hydroxyurea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1b angiotensin II receptor, type 1b increases expression ISO Hydroxyurea results in increased expression of AGTR1B mRNA CTD PMID:27208086 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C multiple interactions ISO Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to ALDOA protein] CTD PMID:20889679 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO Hydroxyurea inhibits the reaction [L 708714 binds to ALOX5 protein] CTD PMID:7577949 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Hydroxyurea results in increased expression of APAF1 mRNA CTD PMID:27208086 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO Hydroxyurea results in increased expression of ATM mRNA CTD PMID:27208086 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of ATP6V1F gene CTD PMID:16868089 NCBI chr 4:58,067,666...58,070,628 JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO [4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine results in decreased activity of ATR] which results in increased susceptibility to Hydroxyurea; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]] CTD PMID:18158334 PMID:21730979 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Atxn1 ataxin 1 decreases expression ISO Hydroxyurea results in decreased expression of ATXN1 mRNA CTD PMID:24211769 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Hydroxyurea results in increased expression of BAX mRNA CTD PMID:16005713 PMID:16356682 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Hydroxyurea results in increased expression of BBC3 mRNA CTD PMID:27208086 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance EXP BCL2L1 gene mutant form results in decreased susceptibility to Hydroxyurea CTD PMID:10970895 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bik BCL2-interacting killer increases expression ISO Hydroxyurea results in increased expression of BIK mRNA CTD PMID:27208086 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
JBrowse link
G Blm BLM RecQ like helicase increases expression
decreases expression
ISO Hydroxyurea results in increased expression of BLM mRNA
Hydroxyurea results in decreased expression of BLM mRNA
CTD PMID:18647660 PMID:24211769 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger decreases expression ISO Hydroxyurea results in decreased expression of BMI1 mRNA CTD PMID:12929121 NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690
JBrowse link
G Bora bora, aurora kinase A activator decreases expression ISO Hydroxyurea results in decreased expression of BORA mRNA CTD PMID:17374387 NCBI chr15:75,797,624...75,835,599
Ensembl chr15:75,797,891...75,821,322
JBrowse link
G Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of BPNT1 gene CTD PMID:16868089 NCBI chr13:96,865,634...96,893,506
Ensembl chr13:96,868,580...96,893,503
JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO Hydroxyurea results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr 1:205,731,814...205,743,430
Ensembl chr 1:205,733,872...205,743,421
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Hydroxyurea results in increased expression of BTG2 mRNA CTD PMID:24211769 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Btg3 BTG anti-proliferation factor 3 decreases expression ISO Hydroxyurea results in decreased expression of BTG3 mRNA CTD PMID:24211769 NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO Bucladesine promotes the reaction [Hydroxyurea results in increased activity of CASP3 protein]; Hydroxyurea promotes the reaction [Valproic Acid results in increased cleavage of CASP3 protein]
Selegiline promotes the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]
CTD PMID:10697531 PMID:16005713 PMID:17653085 PMID:23696560 PMID:29228353 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases expression ISO Hydroxyurea results in increased expression of CASP7 mRNA CTD PMID:27208086 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Ccdc51 coiled-coil domain containing 51 decreases expression ISO Hydroxyurea results in decreased expression of CCDC51 mRNA CTD PMID:24211769 NCBI chr 8:109,722,595...109,741,478
Ensembl chr 8:109,722,557...109,741,472
JBrowse link
G Ccna2 cyclin A2 increases expression ISO Hydroxyurea results in increased expression of CCNA2 protein CTD PMID:11468187 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 increases expression
decreases expression
ISO Hydroxyurea results in increased expression of CCNB1 protein
Hydroxyurea results in decreased expression of CCNB1 protein
CTD PMID:11468187 PMID:16356682 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 increases expression
decreases expression
ISO Hydroxyurea results in increased expression of CCND1 protein
Hydroxyurea results in decreased expression of CCND1 protein
CTD PMID:11468187 PMID:16356682 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 increases expression ISO Hydroxyurea results in increased expression of CCND2 protein CTD PMID:11468187 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccnd3 cyclin D3 increases expression ISO Hydroxyurea results in increased expression of CCND3 protein CTD PMID:11468187 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Hydroxyurea results in increased expression of CCNE1 protein
Hydroxyurea results in increased expression of CCNE1 mRNA
CTD PMID:11468187 PMID:27208086 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO Hydroxyurea results in decreased expression of CCNE2 mRNA CTD PMID:12929121 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccng1 cyclin G1 increases expression ISO Hydroxyurea results in increased expression of CCNG1 mRNA CTD PMID:16005713 PMID:27208086 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Hydroxyurea results in increased expression of CCNG2 mRNA CTD PMID:12929121 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Hydroxyurea results in increased expression of CDC25A mRNA CTD PMID:12929121 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO Hydroxyurea results in decreased expression of CDCA8 mRNA CTD PMID:17374387 NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Hydroxyurea results in decreased expression of CDK4 protein CTD PMID:16356682 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression ISO Hydroxyurea results in increased expression of CDK5R1 mRNA CTD PMID:33770205 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
JBrowse link
G Cdk5rap1 CDK5 regulatory subunit associated protein 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of CDK5RAP1 gene CTD PMID:16868089 NCBI chr 3:142,838,081...142,872,669
Ensembl chr 3:142,708,028...142,872,677
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO
EXP
[Valproic Acid co-treated with Hydroxyurea] results in increased expression of CDKN1A mRNA; Hydroxyurea inhibits the reaction [trichostatin A results in increased expression of CDKN1A protein]; Hydroxyurea inhibits the reaction [Valproic Acid results in increased expression of CDKN1A protein]
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of CDKN1A mRNA]
Hydroxyurea results in increased expression of CDKN1A mRNA; Hydroxyurea results in increased expression of CDKN1A protein
CTD PMID:10961388 PMID:10978678 PMID:15557822 PMID:16005713 PMID:17653085 More... NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of CDKN1B protein
[Valproic Acid co-treated with Hydroxyurea] results in increased expression of CDKN1B mRNA
CTD PMID:10961388 PMID:17653085 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO Hydroxyurea results in increased expression of CDKN1C mRNA CTD PMID:12929121 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
increases expression
ISO Hydroxyurea inhibits the reaction [Azacitidine results in decreased methylation of CDKN2A gene]; Hydroxyurea inhibits the reaction [decitabine results in decreased methylation of CDKN2A gene]
Hydroxyurea results in increased expression of CDKN2A protein
CTD PMID:10961388 PMID:17686055 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Hydroxyurea results in increased expression of CDKN2B mRNA CTD PMID:27208086 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 decreases expression ISO Hydroxyurea results in decreased expression of CEMIP2 mRNA CTD PMID:33770205 NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760
JBrowse link
G Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 decreases expression ISO Hydroxyurea results in decreased expression of CHCHD3 mRNA CTD PMID:12929121 NCBI chr 4:61,360,352...61,616,850
Ensembl chr 4:61,360,353...61,616,847
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases expression
decreases expression
ISO Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]
Hydroxyurea results in increased expression of CHK1 protein modified form
Hydroxyurea results in decreased expression of CHEK1 mRNA
CTD PMID:12929121 PMID:18158334 PMID:21840268 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO Hydroxyurea results in increased expression of CHK2 protein modified form CTD PMID:21840268 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Cideb cell death-inducing DFFA-like effector b decreases expression ISO Hydroxyurea results in decreased expression of CIDEB mRNA CTD PMID:12929121 NCBI chr15:29,252,203...29,256,759
Ensembl chr15:29,252,213...29,256,605
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO Hydroxyurea results in decreased expression of CKS2 mRNA CTD PMID:17374387 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Cln8 CLN8, transmembrane ER and ERGIC protein decreases expression ISO Hydroxyurea results in decreased expression of CLN8 mRNA CTD PMID:24211769 NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774
JBrowse link
G Coa7 cytochrome c oxidase assembly factor 7 decreases expression ISO Hydroxyurea results in decreased expression of COA7 mRNA CTD PMID:24211769 NCBI chr 5:123,069,356...123,080,942
Ensembl chr 5:123,069,371...123,080,199
JBrowse link
G Col1a2 collagen type I alpha 2 chain affects expression ISO Hydroxyurea affects the expression of COL1A2 mRNA CTD PMID:24704097 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Cpb2 carboxypeptidase B2 decreases expression ISO Hydroxyurea results in decreased expression of CPB2 mRNA CTD PMID:12929121 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Hydroxyurea results in decreased expression of CPT2 mRNA CTD PMID:24211769 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of CRADD gene CTD PMID:16868089 NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907
JBrowse link
G Csta cystatin A affects expression ISO Hydroxyurea affects the expression of CSTA mRNA CTD PMID:27825931 NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of CXCR1 gene CTD PMID:16868089 NCBI chr 9:75,768,124...75,771,122
Ensembl chr 9:75,766,770...75,771,084
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO Hydroxyurea results in increased expression of CYP26A1 mRNA CTD PMID:29990529 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Dapk1 death associated protein kinase 1 increases expression ISO Hydroxyurea results in increased expression of DAPK1 mRNA CTD PMID:27208086 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
JBrowse link
G Dclre1c DNA cross-link repair 1C increases response to substance ISO DCLRE1C results in increased susceptibility to Hydroxyurea CTD PMID:21785230 NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186
JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression ISO Hydroxyurea results in increased expression of DDB2 mRNA CTD PMID:18647660 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO Hydroxyurea results in increased expression of DDIT4L mRNA CTD PMID:27208086 NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
JBrowse link
G Dlgap1 DLG associated protein 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of DLGAP1 gene CTD PMID:16868089 NCBI chr 9:109,857,500...110,726,817
Ensembl chr 9:110,167,448...110,726,817
JBrowse link
G Dnmt1 DNA methyltransferase 1 affects response to substance ISO DNMT1 protein affects the susceptibility to Hydroxyurea CTD PMID:17991895 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dym dymeclin increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of DYM gene CTD PMID:16868089 NCBI chr18:68,605,131...68,900,905
Ensembl chr18:68,605,185...68,900,903
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Hydroxyurea results in decreased expression of E2F1 mRNA CTD PMID:24211769 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Hydroxyurea results in increased expression of E2F8 mRNA CTD PMID:33770205 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of ECH1 gene CTD PMID:16868089 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO Hydroxyurea results in increased expression of EDA2R mRNA CTD PMID:27208086 NCBI chr  X:62,224,763...62,269,344
Ensembl chr  X:62,228,229...62,269,268
JBrowse link
G Edn3 endothelin 3 decreases expression ISO Hydroxyurea results in decreased expression of EDN3 protein CTD PMID:15020278 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093
JBrowse link
G Epo erythropoietin increases expression ISO Hydroxyurea results in increased expression of EPO protein CTD PMID:19724057 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease increases expression ISO Hydroxyurea results in increased expression of ERCC5 mRNA CTD PMID:12929121 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 decreases expression ISO Hydroxyurea results in decreased expression of ERRFI1 mRNA CTD PMID:33770205 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Eva1c eva-1 homolog C increases expression ISO Hydroxyurea results in increased expression of EVA1C mRNA CTD PMID:27208086 NCBI chr11:30,089,510...30,163,596
Ensembl chr11:30,089,365...30,163,596
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions ISO [arsenic trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to Hydroxyurea; [monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to Hydroxyurea CTD PMID:25092648 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of FAS mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of FAS mRNA]
CTD PMID:16005713 PMID:16356682 PMID:27208086 PMID:29228353 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression ISO Hydroxyurea results in increased expression of FASL mRNA CTD PMID:16356682 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO Hydroxyurea results in increased expression of FGF8 mRNA CTD PMID:29990529 NCBI chr 1:244,584,477...244,590,359
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
G Fkbp3 FKBP prolyl isomerase 3 increases expression ISO Hydroxyurea results in increased expression of FKBP3 mRNA CTD PMID:12929121 NCBI chr 6:83,113,885...83,125,500
Ensembl chr 6:83,113,786...83,127,011
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Hydroxyurea results in increased expression of and results in increased activity of FOS protein CTD PMID:15772364 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxj2 forkhead box J2 decreases expression ISO Hydroxyurea results in decreased expression of FOXJ2 mRNA CTD PMID:24211769 NCBI chr 4:156,047,043...156,073,540
Ensembl chr 4:156,046,969...156,073,518
JBrowse link
G Foxo1 forkhead box O1 increases expression ISO Hydroxyurea results in increased expression of FOXO1 mRNA CTD PMID:27208086 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Fzd1 frizzled class receptor 1 decreases expression ISO Hydroxyurea results in decreased expression of FZD1 mRNA CTD PMID:24211769 NCBI chr 4:29,310,303...29,314,701 JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Hydroxyurea results in increased expression of GADD45A mRNA CTD PMID:18647660 PMID:27208086 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of GALNT16 gene CTD PMID:16868089 NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:100,170,306...100,250,705
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects localization
decreases activity
multiple interactions
ISO Hydroxyurea affects the localization of GAPDH protein
Hydroxyurea results in decreased activity of GAPDH protein
[Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]] which results in decreased activity of GAPDH protein; [Hydroxyurea results in increased abundance of Free Radicals] promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]; Hydroxyurea affects the metabolism of and results in decreased activity of and affects the localization of GAPDH protein; Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]; Selegiline inhibits the reaction [Hydroxyurea affects the localization of GAPDH protein]
CTD PMID:20889679 PMID:23696560 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Hydroxyurea results in increased expression of GDF15 mRNA CTD PMID:24211769 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease increases expression ISO Hydroxyurea results in increased expression of GEN1 protein CTD PMID:24980922 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 multiple interactions ISO Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GOT2 protein] CTD PMID:20889679 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Grb14 growth factor receptor bound protein 14 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of GRB14 gene CTD PMID:16868089 NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889
JBrowse link
G Grpel1 GrpE-like 1, mitochondrial decreases expression ISO Hydroxyurea results in decreased expression of GRPEL1 mRNA CTD PMID:24211769 NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200
JBrowse link
G H2ax H2A.X variant histone increases expression
increases phosphorylation
multiple interactions
ISO Hydroxyurea results in increased expression of H2AX protein; Hydroxyurea results in increased expression of H2AX protein modified form
Hydroxyurea results in increased phosphorylation of H2AX protein
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased phosphorylation of H2AX protein]
CTD PMID:25125662 PMID:25130544 PMID:29228353 PMID:32482060 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hbp1 HMG-box transcription factor 1 decreases expression ISO Hydroxyurea results in decreased expression of HBP1 mRNA CTD PMID:24211769 NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787
JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions ISO Hydroxyurea promotes the reaction [Valproic Acid results in decreased expression of HDAC2 protein] CTD PMID:17653085 NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hesx1 HESX homeobox 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of HESX1 gene CTD PMID:16868089 NCBI chr16:2,191,852...2,193,957
Ensembl chr16:2,191,852...2,193,957
JBrowse link
G Hoxb9 homeo box B9 decreases expression ISO Hydroxyurea results in decreased expression of HOXB9 mRNA CTD PMID:29990529 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
JBrowse link
G Hoxc6 homeo box C6 decreases expression ISO Hydroxyurea results in decreased expression of HOXC6 mRNA CTD PMID:29990529 NCBI chr 7:134,138,017...134,148,899 JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO Hydroxyurea results in increased expression of HSPA8 mRNA CTD PMID:18647660 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Ier3 immediate early response 3 increases expression ISO Hydroxyurea results in increased expression of IER3 mRNA CTD PMID:12929121 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Il13 interleukin 13 affects expression ISO Hydroxyurea affects the expression of IL13 protein CTD PMID:15927844 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Isg20l2 interferon stimulated exonuclease gene 20-like 2 decreases expression ISO Hydroxyurea results in decreased expression of ISG20L2 mRNA CTD PMID:24211769 NCBI chr 2:173,396,780...173,407,102
Ensembl chr 2:173,396,780...173,406,614
JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 increases expression ISO Hydroxyurea results in increased expression of ITIH2 mRNA CTD PMID:12929121 NCBI chr17:68,375,518...68,411,849
Ensembl chr17:68,375,567...68,411,841
JBrowse link
G Kat2b lysine acetyltransferase 2B increases expression ISO Hydroxyurea results in increased expression of KAT2B mRNA CTD PMID:27208086 NCBI chr 9:6,562,525...6,667,064 JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO Hydroxyurea results in decreased expression of KIF20A mRNA CTD PMID:24211769 NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
JBrowse link
G Kif3b kinesin family member 3B increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of KIF3B gene CTD PMID:16868089 NCBI chr 3:141,758,466...141,798,012
Ensembl chr 3:141,758,466...141,797,963
JBrowse link
G Klrb1a killer cell lectin-like receptor subfamily B, member 1A increases expression ISO Hydroxyurea results in increased expression of KLRB1A mRNA CTD PMID:12929121 NCBI chr 4:161,890,577...161,904,050 JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression ISO Hydroxyurea results in decreased expression of KPNA2 mRNA CTD PMID:17374387 NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases expression ISO Hydroxyurea results in decreased expression of KRAS mRNA CTD PMID:12929121 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lhx2 LIM homeobox 2 decreases expression ISO Hydroxyurea results in decreased expression of LHX2 mRNA CTD PMID:24211769 NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908
JBrowse link
G Liph lipase H decreases expression ISO Hydroxyurea results in decreased expression of LIPH mRNA CTD PMID:33770205 NCBI chr11:79,032,229...79,081,625 JBrowse link
G LOC102548695 zinc finger protein 45-like decreases expression ISO Hydroxyurea results in decreased expression of ZNF45 mRNA CTD PMID:24211769 NCBI chr 1:79,885,875...79,896,601
Ensembl chr 1:79,884,945...79,900,149
JBrowse link
G LOC683674 similar to Protein C7orf26 homolog decreases expression ISO Hydroxyurea results in decreased expression of C7ORF26 mRNA CTD PMID:24211769 NCBI chr12:11,245,045...11,260,170
Ensembl chr12:11,245,842...11,260,166
JBrowse link
G Lrrc47 leucine rich repeat containing 47 decreases expression ISO Hydroxyurea results in decreased expression of LRRC47 mRNA CTD PMID:24211769 NCBI chr 5:164,570,539...164,580,174
Ensembl chr 5:164,570,435...164,580,174
JBrowse link
G Ltb4r leukotriene B4 receptor increases expression ISO Hydroxyurea results in increased expression of LTB4R1 mRNA CTD PMID:27208086 NCBI chr15:29,263,126...29,265,716 JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO Hydroxyurea results in decreased expression of MAD2L1 mRNA CTD PMID:12929121 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of MAD2L2 gene CTD PMID:16868089 NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP Hydroxyurea results in decreased phosphorylation of MAPK1 protein CTD PMID:15557822 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP Hydroxyurea results in decreased phosphorylation of MAPK3 protein CTD PMID:15557822 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation EXP Hydroxyurea results in decreased phosphorylation of MAPK8 protein CTD PMID:15557822 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
affects expression
ISO Hydroxyurea results in increased expression of MDM2 mRNA
Hydroxyurea affects the expression of MDM2 protein
CTD PMID:16356682 PMID:18647660 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mecom MDS1 and EVI1 complex locus increases expression ISO Hydroxyurea results in increased expression of MECOM protein mutant form CTD PMID:16532439 NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression ISO Hydroxyurea results in increased expression of MGMT mRNA CTD PMID:12929121 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mipol1 mirror-image polydactyly 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of MIPOL1 gene CTD PMID:16868089 NCBI chr 6:74,755,314...75,090,403
Ensembl chr 6:74,755,395...75,086,811
JBrowse link
G Mpg N-methylpurine-DNA glycosylase increases expression ISO Hydroxyurea results in increased expression of MPG mRNA CTD PMID:12929121 NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520
JBrowse link
G Mpzl1 myelin protein zero-like 1 decreases expression ISO Hydroxyurea results in decreased expression of MPZL1 mRNA CTD PMID:24211769 NCBI chr13:77,852,467...77,889,305
Ensembl chr13:77,852,467...77,896,616
JBrowse link
G Mrm2 mitochondrial rRNA methyltransferase 2 decreases expression ISO Hydroxyurea results in decreased expression of MRM2 mRNA CTD PMID:24211769 NCBI chr12:14,309,556...14,314,759
Ensembl chr12:14,251,941...14,314,118
JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO Hydroxyurea results in decreased expression of MSH6 mRNA CTD PMID:24211769 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
JBrowse link
G Mxi1 MAX interactor 1, dimerization protein decreases expression ISO Hydroxyurea results in decreased expression of MXI1 mRNA CTD PMID:33770205 NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681
JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO Hydroxyurea results in decreased expression of MYB mRNA CTD PMID:12929121 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Myo1e myosin IE decreases expression ISO Hydroxyurea results in decreased expression of MYO1E mRNA CTD PMID:33770205 NCBI chr 8:70,887,934...71,080,180
Ensembl chr 8:70,887,870...71,080,169
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase decreases expression ISO Hydroxyurea results in decreased expression of NAMPT mRNA CTD PMID:12929121 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Nek3 NIMA-related kinase 3 decreases expression ISO Hydroxyurea results in decreased expression of NEK3 mRNA CTD PMID:12929121 NCBI chr16:69,867,020...69,892,477
Ensembl chr16:69,867,047...69,892,508
JBrowse link
G Neurod4 neuronal differentiation 4 decreases expression ISO Hydroxyurea results in decreased expression of NEUROD4 mRNA CTD PMID:12929121 NCBI chr 7:7,090,048...7,102,018
Ensembl chr 7:7,090,045...7,102,030
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO Hydroxyurea results in increased expression of NFKB1 mRNA CTD PMID:18647660 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Hydroxyurea results in increased expression of NFKBIA mRNA CTD PMID:18647660 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nop58 NOP58 ribonucleoprotein decreases expression ISO Hydroxyurea results in decreased expression of NOL5 mRNA CTD PMID:12929121 NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810
JBrowse link
G Nudt12 nudix hydrolase 12 increases expression ISO Hydroxyurea results in increased expression of NUDT12 mRNA CTD PMID:12929121 NCBI chr 9:98,741,627...98,755,039
Ensembl chr 9:98,742,360...98,755,039
JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit decreases expression ISO Hydroxyurea results in decreased expression of NUS1 mRNA CTD PMID:12929121 NCBI chr20:31,811,817...31,838,562
Ensembl chr20:31,811,817...31,838,561
JBrowse link
G P2ry6 pyrimidinergic receptor P2Y6 increases expression ISO Hydroxyurea results in increased expression of P2RY6 mRNA CTD PMID:27208086 NCBI chr 1:155,295,110...155,330,610
Ensembl chr 1:155,295,111...155,330,808
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Hydroxyurea results in increased expression of PCNA mRNA CTD PMID:18647660 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pelo pelota mRNA surveillance and ribosome rescue factor decreases expression ISO Hydroxyurea results in decreased expression of PELO mRNA CTD PMID:24211769 NCBI chr 2:46,797,853...46,799,621
Ensembl chr 2:46,797,853...46,799,746
JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression ISO Hydroxyurea results in increased expression of PERP mRNA CTD PMID:27208086 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO Hydroxyurea results in increased expression of PHLDA3 mRNA CTD PMID:24211769 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
JBrowse link
G Pidd1 p53-induced death domain protein 1 increases expression ISO Hydroxyurea results in increased expression of PIDD1 mRNA CTD PMID:27208086 NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
JBrowse link
G Pklr pyruvate kinase L/R decreases expression ISO Hydroxyurea results in decreased expression of PKLR mRNA CTD PMID:12929121 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of PMAIP1 mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of PMAIP1 mRNA]
CTD PMID:27208086 PMID:29228353 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Pml PML nuclear body scaffold increases expression ISO Hydroxyurea results in increased expression of PML mRNA CTD PMID:27208086 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Polh DNA polymerase eta increases expression ISO Hydroxyurea results in increased expression of POLH mRNA CTD PMID:25125662 NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D increases expression ISO Hydroxyurea results in increased expression of PPM1D mRNA CTD PMID:24211769 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A decreases expression ISO Hydroxyurea results in decreased expression of PPP1R12A mRNA CTD PMID:12929121 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Hydroxyurea results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 increases expression ISO Hydroxyurea results in increased expression of PRKAB1 mRNA CTD PMID:24211769 NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661
JBrowse link
G Prrg4 proline rich and Gla domain 4 increases expression ISO Hydroxyurea results in increased expression of PRRG4 mRNA CTD PMID:27208086 NCBI chr 3:91,214,646...91,243,347
Ensembl chr 3:91,214,653...91,243,273
JBrowse link
G Prune1 prune exopolyphosphatase 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of PRUNE1 gene CTD PMID:16868089 NCBI chr 2:182,830,575...182,859,972
Ensembl chr 2:182,830,578...182,859,336
JBrowse link
G Psip1 PC4 and SFRS1 interacting protein 1 decreases expression ISO Hydroxyurea results in decreased expression of PSIP1 mRNA CTD PMID:12929121 NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257
JBrowse link
G Psrc1 proline and serine rich coiled-coil 1 decreases expression ISO Hydroxyurea results in decreased expression of PSRC1 mRNA CTD PMID:17374387 NCBI chr 2:196,022,361...196,026,874
Ensembl chr 2:196,022,361...196,026,874
JBrowse link
G Pus3 pseudouridine synthase 3 decreases expression ISO Hydroxyurea results in decreased expression of PUS3 mRNA CTD PMID:24211769 NCBI chr 8:33,910,461...33,918,716
Ensembl chr 8:33,911,357...33,918,714
JBrowse link
G Rab34 RAB34, member RAS oncogene family increases expression ISO Hydroxyurea results in increased expression of RAB34 mRNA CTD PMID:12929121 NCBI chr10:63,083,319...63,087,538
Ensembl chr10:63,083,338...63,087,538
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO Hydroxyurea results in decreased expression of RAD23A mRNA CTD PMID:12929121 NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695
JBrowse link
G Rad51c RAD51 paralog C increases expression ISO Hydroxyurea results in increased expression of RAD51C mRNA CTD PMID:27825931 NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248
JBrowse link
G Ran RAN, member RAS oncogene family decreases expression ISO Hydroxyurea results in decreased expression of RAN mRNA CTD PMID:12929121 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
JBrowse link
G Rap2b RAP2B, member of RAS oncogene family decreases expression ISO Hydroxyurea results in decreased expression of RAP2B mRNA CTD PMID:24211769 NCBI chr 2:145,599,714...145,600,265
Ensembl chr 2:145,599,116...145,603,069
JBrowse link
G Rara retinoic acid receptor, alpha increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of RARA gene CTD PMID:16868089 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of RB1 mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of RB1 mRNA]
CTD PMID:27208086 PMID:29228353 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbm4 RNA binding motif protein 4 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of RBM4 gene CTD PMID:16868089 NCBI chr 1:202,078,442...202,087,506
Ensembl chr 1:202,085,279...202,105,380
JBrowse link
G Rfx4 regulatory factor X4 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of RFX4 gene CTD PMID:16868089 NCBI chr 7:18,853,065...19,015,378
Ensembl chr 7:18,853,322...19,014,967
JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO Hydroxyurea results in increased expression of RGS16 mRNA CTD PMID:24211769 NCBI chr13:65,887,788...65,891,232
Ensembl chr13:65,887,530...65,892,857
JBrowse link
G Rnf113a1 ring finger protein 113A1 decreases expression ISO Hydroxyurea results in decreased expression of RNF113A mRNA CTD PMID:24211769 NCBI chr  X:116,428,037...116,429,164
Ensembl chr  X:116,427,684...116,433,762
JBrowse link
G Rnf19a ring finger protein 19A, RBR E3 ubiquitin protein ligase decreases expression ISO Hydroxyurea results in decreased expression of RNF19A mRNA CTD PMID:12929121 NCBI chr 7:67,425,833...67,465,214
Ensembl chr 7:67,425,837...67,465,222
JBrowse link
G Rnf24 ring finger protein 24 decreases expression ISO Hydroxyurea results in decreased expression of RNF24 mRNA CTD PMID:33770205 NCBI chr 3:118,525,349...118,526,312
Ensembl chr 3:118,525,349...118,541,080
JBrowse link
G Rnf4 ring finger protein 4 decreases response to substance EXP RNF4 protein results in decreased susceptibility to Hydroxyurea CTD PMID:22661230 NCBI chr14:76,401,292...76,423,270
Ensembl chr14:76,401,299...76,422,566
JBrowse link
G Rpl22l1 ribosomal protein L22 like 1 decreases expression ISO Hydroxyurea results in decreased expression of RPL22L1 mRNA CTD PMID:12929121 NCBI chr 2:111,754,687...111,756,623
Ensembl chr 2:111,754,687...111,756,625
JBrowse link
G Rras RAS related increases expression ISO Hydroxyurea results in increased expression of RRAS mRNA CTD PMID:12929121 NCBI chr 1:95,500,582...95,504,362
Ensembl chr 1:95,500,566...95,504,357
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases activity ISO Hydroxyurea results in decreased activity of RRM2 protein CTD PMID:22403396 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO Hydroxyurea results in increased expression of RRM2B mRNA CTD PMID:18647660 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression ISO Hydroxyurea results in increased expression of RUNX1 protein mutant form CTD PMID:16532439 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G Runx2 RUNX family transcription factor 2 affects expression ISO Hydroxyurea affects the expression of RUNX2 mRNA CTD PMID:24704097 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sesn1 sestrin 1 increases expression ISO Hydroxyurea results in increased expression of SESN1 mRNA CTD PMID:24211769 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Hydroxyurea results in increased expression of SGK1 mRNA CTD PMID:18647660 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Slbp stem-loop binding protein decreases expression ISO Hydroxyurea results in decreased expression of SLBP mRNA CTD PMID:24211769 NCBI chr14:77,071,441...77,081,911
Ensembl chr14:77,071,632...77,081,906
JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) affects transport
increases uptake
ISO SLC14A1 protein affects the transport of Hydroxyurea
SLC14A1 protein results in increased uptake of Hydroxyurea
CTD PMID:17506977 PMID:21256917 NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146
JBrowse link
G Slc14a2 solute carrier family 14 member 2 increases uptake ISO SLC14A2 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr18:71,612,460...72,039,462
Ensembl chr18:71,612,460...71,792,968
JBrowse link
G Slc16a12 solute carrier family 16, member 12 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of SLC16A12 gene CTD PMID:16868089 NCBI chr 1:232,184,004...232,262,170
Ensembl chr 1:232,185,907...232,262,141
JBrowse link
G Slc1a5 solute carrier family 1 member 5 decreases expression ISO Hydroxyurea results in decreased expression of SLC1A5 mRNA CTD PMID:24211769 NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952
JBrowse link
G Slc22a4 solute carrier family 22 member 4 increases uptake ISO SLC22A4 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr10:38,133,333...38,179,932 JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases uptake ISO SLC22A5 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases uptake ISO SLCO1A2 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases uptake
ISO naringin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea] CTD PMID:21256917 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Smim14 small integral membrane protein 14 decreases expression ISO Hydroxyurea results in decreased expression of SMIM14 mRNA CTD PMID:33770205 NCBI chr14:42,783,361...42,829,762
Ensembl chr14:42,783,332...42,829,760
JBrowse link
G Snca synuclein alpha multiple interactions ISO Hydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to ferrous chloride]; Hydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to Iron] CTD PMID:14535945 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Spink4 serine peptidase inhibitor, Kazal type 4 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of SPINK4 gene CTD PMID:16868089 NCBI chr 5:56,053,104...56,065,029
Ensembl chr 5:55,981,624...56,064,795
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Hydroxyurea results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Stk4 serine/threonine kinase 4 increases cleavage
multiple interactions
ISO Hydroxyurea results in increased cleavage of STK4 protein
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of STK4 protein]
CTD PMID:29228353 NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744
JBrowse link
G Svop SV2 related protein increases expression ISO Hydroxyurea results in increased expression of SVOP mRNA CTD PMID:27208086 NCBI chr12:42,530,902...42,589,736
Ensembl chr12:42,531,032...42,590,572
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression ISO Hydroxyurea results in increased expression of TAP1 mRNA CTD PMID:27208086 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
JBrowse link
G Tbpl1 TATA-box binding protein like 1 affects localization ISO Hydroxyurea affects the localization of TBPL1 protein CTD PMID:17085973 NCBI chr 1:22,777,892...22,803,305
Ensembl chr 1:22,778,459...22,803,122
Ensembl chr 1:22,778,459...22,803,122
JBrowse link
G Tbx6 T-box transcription factor 6 decreases expression ISO Hydroxyurea results in decreased expression of TBX6 mRNA CTD PMID:29990529 NCBI chr 1:181,387,851...181,392,762
Ensembl chr 1:181,388,684...181,392,593
JBrowse link
G Tfec transcription factor EC decreases expression ISO Hydroxyurea results in decreased expression of TFEC mRNA CTD PMID:24211769 NCBI chr 4:45,106,129...45,180,236
Ensembl chr 4:45,107,641...45,180,236
JBrowse link
G Tipin timeless interacting protein decreases expression ISO Hydroxyurea results in decreased expression of TIPIN mRNA CTD PMID:24211769 NCBI chr 8:64,780,741...64,801,355
Ensembl chr 8:64,780,828...64,801,352
JBrowse link
G Tmem185b transmembrane protein 185B decreases expression ISO Hydroxyurea results in decreased expression of TMEM185B mRNA CTD PMID:24211769 NCBI chr13:30,647,533...30,650,864
Ensembl chr13:30,647,482...30,650,858
JBrowse link
G Tmem250 transmembrane protein 250 increases expression ISO Hydroxyurea results in increased expression of TMEM250 mRNA CTD PMID:33770205 NCBI chr 3:8,962,657...8,966,349
Ensembl chr 3:8,962,657...8,966,349
JBrowse link
G Tmem69 transmembrane protein 69 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of TMEM69 gene CTD PMID:16868089 NCBI chr 5:130,004,888...130,008,466
Ensembl chr 5:130,004,901...130,010,655
JBrowse link
G Tnf tumor necrosis factor increases secretion ISO Hydroxyurea results in increased secretion of TNF protein CTD PMID:14965870 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO Hydroxyurea results in increased expression of TNFRSF10A mRNA CTD PMID:27208086 NCBI chr15:44,839,818...44,867,582 JBrowse link
G Top1 DNA topoisomerase I decreases expression ISO Hydroxyurea results in decreased expression of TOP1 mRNA CTD PMID:12929121 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Tor1a torsin family 1, member A decreases expression ISO Hydroxyurea results in decreased expression of TOR1A mRNA CTD PMID:24211769 NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691
JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects response to substance
increases expression
ISO Hydroxyurea results in increased expression of and results in increased phosphorylation of TRP53 protein; Hydroxyurea results in increased phosphorylation of and results in increased activity of and affects the localization of TRP53 protein; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of STK4 protein]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of CDKN1A mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of FAS mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of PMAIP1 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of RB1 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP53INP1 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP73 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased phosphorylation of H2AX protein]
TRP53 affects the susceptibility to Hydroxyurea
Hydroxyurea results in increased expression of TP53 protein; Hydroxyurea results in increased expression of TP53 protein modified form
CTD PMID:10978678 PMID:16005713 PMID:16356682 PMID:21840268 PMID:25125662 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of TRP53INP1 mRNA; Hydroxyurea results in increased expression of TRP53INP1 protein
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP53INP1 mRNA]
CTD PMID:27208086 PMID:29228353 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
JBrowse link
G Tp63 tumor protein p63 decreases expression ISO Hydroxyurea results in decreased expression of TRP63 mRNA CTD PMID:29228353 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link
G Tp73 tumor protein p73 increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of TRP73 mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP73 mRNA]
CTD PMID:29228353 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
JBrowse link
G Tpp2 tripeptidyl peptidase 2 affects localization ISO Hydroxyurea affects the localization of TPP2 protein CTD PMID:20643100 NCBI chr 9:46,046,712...46,128,157
Ensembl chr 9:46,046,632...46,128,157
JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO Hydroxyurea promotes the reaction [Valproic Acid results in increased expression of TRADD protein] CTD PMID:17653085 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 increases expression ISO Hydroxyurea results in increased expression of TRIAP1 mRNA CTD PMID:18647660 NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042
JBrowse link
G Trim32 tripartite motif-containing 32 decreases expression ISO Hydroxyurea results in decreased expression of TRIM32 mRNA CTD PMID:24211769 NCBI chr 5:79,005,139...79,016,615
Ensembl chr 5:78,999,389...79,022,018
JBrowse link
G Trim38 tripartite motif containing 38 decreases expression ISO Hydroxyurea results in decreased expression of TRIM38 mRNA CTD PMID:24211769 NCBI chr17:41,351,857...41,365,021 JBrowse link
G Trim68 tripartite motif containing 68 increases expression ISO Hydroxyurea results in increased expression of TRIM68 mRNA CTD PMID:12929121 NCBI chr 1:157,114,044...157,127,494
Ensembl chr 1:157,114,044...157,127,477
JBrowse link
G Ubac2 UBA domain containing 2 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of UBAC2 gene CTD PMID:16868089 NCBI chr15:98,960,139...99,107,795
Ensembl chr15:98,960,139...99,107,787
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO Hydroxyurea results in decreased expression of UBE2C mRNA CTD PMID:17374387 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Utp3 UTP3, small subunit processome component decreases expression ISO Hydroxyurea results in decreased expression of UTP3 mRNA CTD PMID:24211769 NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396
JBrowse link
G Wnt3a Wnt family member 3A decreases expression ISO Hydroxyurea results in decreased expression of WNT3A mRNA CTD PMID:29990529 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor increases expression ISO Hydroxyurea results in increased expression of XPC mRNA CTD PMID:18647660 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases response to substance ISO XRCC4 results in decreased susceptibility to Hydroxyurea CTD PMID:21785230 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression
increases mutagenesis
ISO Hydroxyurea results in decreased expression of XRCC5 mRNA
Hydroxyurea results in increased mutagenesis of XRCC5 gene
CTD PMID:12929121 PMID:16868089 NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018
JBrowse link
G Zbtb24 zinc finger and BTB domain containing 24 decreases expression ISO Hydroxyurea results in decreased expression of ZBTB24 mRNA CTD PMID:24211769 NCBI chr20:44,943,302...44,965,329
Ensembl chr20:44,947,297...44,963,963
JBrowse link
G Zfp280c zinc finger protein 280C decreases expression ISO Hydroxyurea results in decreased expression of ZNF280C mRNA CTD PMID:33770205 NCBI chr  X:127,716,403...127,807,600
Ensembl chr  X:127,717,983...127,779,825
JBrowse link
G Zfp365 zinc finger protein 365 increases expression ISO Hydroxyurea results in increased expression of ZFP365 mRNA CTD PMID:27208086 NCBI chr20:20,666,240...20,689,734
Ensembl chr20:20,666,240...20,691,238
JBrowse link
G Zfp385a zinc finger protein 385A increases expression ISO Hydroxyurea results in increased expression of ZFP385A mRNA CTD PMID:12929121 NCBI chr 7:134,448,914...134,475,548
Ensembl chr 7:134,448,921...134,475,548
JBrowse link
G Znf750 zinc finger protein 750 increases expression ISO Hydroxyurea results in increased expression of ZFP750 mRNA CTD PMID:27208086 NCBI chr10:106,772,162...106,781,186
Ensembl chr10:106,772,669...106,781,200
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        immunomodulator 14903
          hydroxyurea 226
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                monocarboxylic acid amide 15014
                                                  urea 5112
                                                    ureas 5109
                                                      hydroxyurea 226
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