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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxyurea
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Accession:CHEBI:44423 term browser browse the term
Definition:A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.
Synonyms:related_synonym: Formula=CH4N2O2;   Hydroxycarbamid;   Hydroxycarbamide;   Hydroxyharnstoff;   InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4);   InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N;   N-HYDROXYUREA;   N-carbamoylhydroxylamine;   SMILES=NC(=O)NO;   carbamohydroxamic acid;   carbamohydroximic acid;   carbamoyl oxime;   carbamyl hydroxamate;   hidroxicarbamida;   hydrea;   hydroxycarbamidum;   oxyurea
 alt_id: CHEBI:44420;   CHEBI:5816
 xref: Beilstein:1741548;   CAS:127-07-1;   DrugBank:DB01005;   Drug_Central:1399;   Gmelin:130423;   HMDB:HMDB0015140;   KEGG:C07044;   KEGG:D00341
 xref_mesh: MESH:D006918
 xref: MetaCyc:HYDROXY-UREA;   PDBeChem:NHY;   PMID:11285159;   PMID:11298103;   PMID:11364534;   PMID:11365149;   PMID:11391710;   PMID:12107454;   PMID:14988684;   PMID:15772364;   PMID:15994344;   PMID:16356682;   PMID:22983419;   PMID:23318979;   PMID:23643402;   PMID:23696560;   PMID:9271088;   Patent:US2705727;   Reaxys:1741548;   Wikipedia:Hydroxyurea


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hydroxyurea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1b angiotensin II receptor, type 1b increases expression ISO Hydroxyurea results in increased expression of AGTR1B mRNA CTD PMID:27208086 NCBI chr 2:105,149,020...105,224,335
Ensembl chr 2:105,149,020...105,224,295
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A multiple interactions ISO Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to ALDOA protein] CTD PMID:20889679 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO Hydroxyurea inhibits the reaction [L 708714 binds to ALOX5 protein] CTD PMID:7577949 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Hydroxyurea results in increased expression of APAF1 mRNA CTD PMID:27208086 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO Hydroxyurea results in increased expression of ATM mRNA CTD PMID:27208086 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of ATP6V1F gene CTD PMID:16868089 NCBI chr 4:56,744,563...56,747,657
Ensembl chr 4:56,744,561...56,747,656
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO [4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine results in decreased activity of ATR] which results in increased susceptibility to Hydroxyurea; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]] CTD PMID:18158334, PMID:21730979 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Atxn1 ataxin 1 decreases expression ISO Hydroxyurea results in decreased expression of ATXN1 mRNA CTD PMID:24211769 NCBI chr17:19,160,986...19,533,814
Ensembl chr17:19,249,952...19,533,814
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Hydroxyurea results in increased expression of BAX mRNA CTD PMID:16005713, PMID:16356682 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Hydroxyurea results in increased expression of BBC3 mRNA CTD PMID:27208086 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance EXP BCL2L1 gene mutant form results in decreased susceptibility to Hydroxyurea CTD PMID:10970895 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bik BCL2-interacting killer increases expression ISO Hydroxyurea results in increased expression of BIK mRNA CTD PMID:27208086 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G Blm BLM RecQ like helicase increases expression
decreases expression
ISO Hydroxyurea results in increased expression of BLM mRNA
Hydroxyurea results in decreased expression of BLM mRNA
CTD PMID:18647660, PMID:24211769 NCBI chr 1:142,246,773...142,332,616
Ensembl chr 1:142,246,790...142,332,588
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger decreases expression ISO Hydroxyurea results in decreased expression of BMI1 mRNA CTD PMID:12929121 NCBI chr17:85,360,439...85,370,283
Ensembl chr17:85,364,483...85,368,208
JBrowse link
G Bora bora, aurora kinase A activator decreases expression ISO Hydroxyurea results in decreased expression of BORA mRNA CTD PMID:17374387 NCBI chr15:83,442,217...83,463,737
Ensembl chr15:83,442,144...83,463,717
JBrowse link
G Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of BPNT1 gene CTD PMID:16868089 NCBI chr13:103,268,045...103,292,848
Ensembl chr13:103,268,068...103,292,854
JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO Hydroxyurea results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr 1:225,035,956...225,046,137
Ensembl chr 1:225,037,737...225,046,040
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Hydroxyurea results in increased expression of BTG2 mRNA CTD PMID:24211769 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Btg3 BTG anti-proliferation factor 3 decreases expression ISO Hydroxyurea results in decreased expression of BTG3 mRNA CTD PMID:24211769 NCBI chr11:16,873,642...16,889,100
Ensembl chr11:16,873,646...16,889,201
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO Bucladesine promotes the reaction [Hydroxyurea results in increased activity of CASP3 protein]; Hydroxyurea promotes the reaction [Valproic Acid results in increased cleavage of CASP3 protein]
Selegiline promotes the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]
CTD PMID:10697531, PMID:16005713, PMID:17653085, PMID:23696560, PMID:29228353 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases expression ISO Hydroxyurea results in increased expression of CASP7 mRNA CTD PMID:27208086 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Ccdc51 coiled-coil domain containing 51 decreases expression ISO Hydroxyurea results in decreased expression of CCDC51 mRNA CTD PMID:24211769 NCBI chr 8:117,812,091...117,830,848
Ensembl chr 8:117,812,099...117,830,868
JBrowse link
G Ccna2 cyclin A2 increases expression ISO Hydroxyurea results in increased expression of CCNA2 protein CTD PMID:11468187 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 increases expression
decreases expression
ISO Hydroxyurea results in increased expression of CCNB1 protein
Hydroxyurea results in decreased expression of CCNB1 protein
CTD PMID:11468187, PMID:16356682 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 increases expression
decreases expression
ISO Hydroxyurea results in increased expression of CCND1 protein
Hydroxyurea results in decreased expression of CCND1 protein
CTD PMID:11468187, PMID:16356682 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 increases expression ISO Hydroxyurea results in increased expression of CCND2 protein CTD PMID:11468187 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 increases expression ISO Hydroxyurea results in increased expression of CCND3 protein CTD PMID:11468187 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Hydroxyurea results in increased expression of CCNE1 protein
Hydroxyurea results in increased expression of CCNE1 mRNA
CTD PMID:11468187, PMID:27208086 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO Hydroxyurea results in decreased expression of CCNE2 mRNA CTD PMID:12929121 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccng1 cyclin G1 increases expression ISO Hydroxyurea results in increased expression of CCNG1 mRNA CTD PMID:16005713, PMID:27208086 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Hydroxyurea results in increased expression of CCNG2 mRNA CTD PMID:12929121 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Hydroxyurea results in increased expression of CDC25A mRNA CTD PMID:12929121 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO Hydroxyurea results in decreased expression of CDCA8 mRNA CTD PMID:17374387 NCBI chr 5:142,911,310...142,933,536
Ensembl chr 5:142,911,305...142,933,526
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Hydroxyurea results in decreased expression of CDK4 protein CTD PMID:16356682 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk5rap1 CDK5 regulatory subunit associated protein 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of CDK5RAP1 gene CTD PMID:16868089 NCBI chr 3:149,835,953...149,870,429
Ensembl chr 3:149,703,848...149,870,413
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO
EXP
[Valproic Acid co-treated with Hydroxyurea] results in increased expression of CDKN1A mRNA; Hydroxyurea inhibits the reaction [trichostatin A results in increased expression of CDKN1A protein]; Hydroxyurea inhibits the reaction [Valproic Acid results in increased expression of CDKN1A protein]
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of CDKN1A mRNA]
Hydroxyurea results in increased expression of CDKN1A mRNA; Hydroxyurea results in increased expression of CDKN1A protein
CTD PMID:10961388, PMID:10978678, PMID:15557822, PMID:16005713, PMID:17653085, PMID:18647660, PMID:21840268, PMID:24211769, PMID:27208086, PMID:29228353 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of CDKN1B protein
[Valproic Acid co-treated with Hydroxyurea] results in increased expression of CDKN1B mRNA
CTD PMID:10961388, PMID:17653085 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO Hydroxyurea results in increased expression of CDKN1C mRNA CTD PMID:12929121 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
increases expression
ISO Hydroxyurea inhibits the reaction [Azacitidine results in decreased methylation of CDKN2A gene]; Hydroxyurea inhibits the reaction [decitabine results in decreased methylation of CDKN2A gene]
Hydroxyurea results in increased expression of CDKN2A protein
CTD PMID:10961388, PMID:17686055 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Hydroxyurea results in increased expression of CDKN2B mRNA CTD PMID:27208086 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 decreases expression ISO Hydroxyurea results in decreased expression of CHCHD3 mRNA CTD PMID:12929121 NCBI chr 4:60,080,536...60,358,592
Ensembl chr 4:60,080,538...60,358,562
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases expression
decreases expression
ISO Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]
Hydroxyurea results in increased expression of CHK1 protein modified form
Hydroxyurea results in decreased expression of CHEK1 mRNA
CTD PMID:12929121, PMID:18158334, PMID:21840268 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO Hydroxyurea results in increased expression of CHK2 protein modified form CTD PMID:21840268 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cideb cell death-inducing DFFA-like effector b decreases expression ISO Hydroxyurea results in decreased expression of CIDEB mRNA CTD PMID:12929121 NCBI chr15:34,439,844...34,444,244
Ensembl chr15:34,439,876...34,444,244
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO Hydroxyurea results in decreased expression of CKS2 mRNA CTD PMID:17374387 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
JBrowse link
G Cln8 CLN8, transmembrane ER and ERGIC protein decreases expression ISO Hydroxyurea results in decreased expression of CLN8 mRNA CTD PMID:24211769 NCBI chr16:79,828,321...79,838,212
Ensembl chr16:79,828,324...79,838,212
JBrowse link
G Coa7 cytochrome c oxidase assembly factor 7 decreases expression ISO Hydroxyurea results in decreased expression of COA7 mRNA CTD PMID:24211769 NCBI chr 5:127,925,726...127,936,516
Ensembl chr 5:127,925,726...127,936,509
JBrowse link
G Col1a2 collagen type I alpha 2 chain affects expression ISO Hydroxyurea affects the expression of COL1A2 mRNA CTD PMID:24704097 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Cpb2 carboxypeptidase B2 decreases expression ISO Hydroxyurea results in decreased expression of CPB2 mRNA CTD PMID:12929121 NCBI chr15:57,290,849...57,339,762
Ensembl chr15:57,290,849...57,339,760
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Hydroxyurea results in decreased expression of CPT2 mRNA CTD PMID:24211769 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of CRADD gene CTD PMID:16868089 NCBI chr 7:36,395,665...36,408,588
Ensembl chr 7:36,395,665...36,408,588
JBrowse link
G Csta cystatin A affects expression ISO Hydroxyurea affects the expression of CSTA mRNA CTD PMID:27825931 NCBI chr11:67,555,792...67,566,980
Ensembl chr11:67,555,658...67,566,972
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of CXCR1 gene CTD PMID:16868089 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO Hydroxyurea results in increased expression of CYP26A1 mRNA CTD PMID:29990529 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Dapk1 death associated protein kinase 1 increases expression ISO Hydroxyurea results in increased expression of DAPK1 mRNA CTD PMID:27208086 NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778
JBrowse link
G Dclre1c DNA cross-link repair 1C increases response to substance ISO DCLRE1C results in increased susceptibility to Hydroxyurea CTD PMID:21785230 NCBI chr17:78,782,512...78,812,140
Ensembl chr17:78,783,437...78,812,111
JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression ISO Hydroxyurea results in increased expression of DDB2 mRNA CTD PMID:18647660 NCBI chr 3:80,030,437...80,052,984
Ensembl chr 3:80,030,437...80,052,953
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO Hydroxyurea results in increased expression of DDIT4L mRNA CTD PMID:27208086 NCBI chr 2:242,882,219...242,885,088
Ensembl chr 2:242,882,306...242,885,131
JBrowse link
G Dlgap1 DLG associated protein 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of DLGAP1 gene CTD PMID:16868089 NCBI chr 9:118,277,046...119,159,807
Ensembl chr 9:118,586,179...119,158,196
JBrowse link
G Dnmt1 DNA methyltransferase 1 affects response to substance ISO DNMT1 protein affects the susceptibility to Hydroxyurea CTD PMID:17991895 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dym dymeclin increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of DYM gene CTD PMID:16868089 NCBI chr18:70,996,074...71,313,033
Ensembl chr18:70,996,044...71,313,084
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Hydroxyurea results in decreased expression of E2F1 mRNA CTD PMID:24211769 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of ECH1 gene CTD PMID:16868089 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO Hydroxyurea results in increased expression of EDA2R mRNA CTD PMID:27208086 NCBI chr  X:66,560,200...66,602,509
Ensembl chr  X:66,561,286...66,602,506
JBrowse link
G Edn3 endothelin 3 decreases expression ISO Hydroxyurea results in decreased expression of EDN3 protein CTD PMID:15020278 NCBI chr 3:172,856,730...172,879,276
Ensembl chr 3:172,856,733...172,880,450
JBrowse link
G Epo erythropoietin increases expression ISO Hydroxyurea results in increased expression of EPO protein CTD PMID:19724057 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease increases expression ISO Hydroxyurea results in increased expression of ERCC5 mRNA CTD PMID:12929121 NCBI chr 9:50,928,847...50,970,962
Ensembl chr 9:50,925,619...50,970,955
JBrowse link
G Eva1c eva-1 homolog C increases expression ISO Hydroxyurea results in increased expression of EVA1C mRNA CTD PMID:27208086 NCBI chr11:31,001,697...31,075,784
Ensembl chr11:31,002,451...31,075,809
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions ISO [arsenic trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to Hydroxyurea; [monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to Hydroxyurea CTD PMID:25092648 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of FAS mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of FAS mRNA]
CTD PMID:16005713, PMID:16356682, PMID:27208086, PMID:29228353 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression ISO Hydroxyurea results in increased expression of FASL mRNA CTD PMID:16356682 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO Hydroxyurea results in increased expression of FGF8 mRNA CTD PMID:29990529 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831
JBrowse link
G Fkbp3 FKBP prolyl isomerase 3 increases expression ISO Hydroxyurea results in increased expression of FKBP3 mRNA CTD PMID:12929121 NCBI chr 6:86,810,865...86,822,115
Ensembl chr 6:86,810,809...86,822,094
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Hydroxyurea results in increased expression of and results in increased activity of FOS protein CTD PMID:15772364 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxj2 forkhead box J2 decreases expression ISO Hydroxyurea results in decreased expression of FOXJ2 mRNA CTD PMID:24211769 NCBI chr 4:155,653,446...155,679,815
Ensembl chr 4:155,653,718...155,679,793
JBrowse link
G Foxo1 forkhead box O1 increases expression ISO Hydroxyurea results in increased expression of FOXO1 mRNA CTD PMID:27208086 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Fzd1 frizzled class receptor 1 decreases expression ISO Hydroxyurea results in decreased expression of FZD1 mRNA CTD PMID:24211769 NCBI chr 4:26,470,864...26,475,262
Ensembl chr 4:26,470,864...26,475,262
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Hydroxyurea results in increased expression of GADD45A mRNA CTD PMID:18647660, PMID:27208086 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of GALNT16 gene CTD PMID:16868089 NCBI chr 6:104,069,853...104,250,177
Ensembl chr 6:104,068,547...104,250,174
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects localization
decreases activity
multiple interactions
ISO Hydroxyurea affects the localization of GAPDH protein
Hydroxyurea results in decreased activity of GAPDH protein
[Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]] which results in decreased activity of GAPDH protein; [Hydroxyurea results in increased abundance of Free Radicals] promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]; Hydroxyurea affects the metabolism of and results in decreased activity of and affects the localization of GAPDH protein; Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]; Selegiline inhibits the reaction [Hydroxyurea affects the localization of GAPDH protein]
CTD PMID:20889679, PMID:23696560 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Hydroxyurea results in increased expression of GDF15 mRNA CTD PMID:24211769 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease increases expression ISO Hydroxyurea results in increased expression of GEN1 protein CTD PMID:24980922 NCBI chr 6:36,910,064...36,940,868
Ensembl chr 6:36,910,675...36,940,868
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 multiple interactions ISO Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GOT2 protein] CTD PMID:20889679 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Grb14 growth factor receptor bound protein 14 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of GRB14 gene CTD PMID:16868089 NCBI chr 3:50,937,403...51,054,447
Ensembl chr 3:50,937,669...51,054,378
JBrowse link
G Grpel1 GrpE-like 1, mitochondrial decreases expression ISO Hydroxyurea results in decreased expression of GRPEL1 mRNA CTD PMID:24211769 NCBI chr14:79,458,951...79,464,782
Ensembl chr14:79,458,963...79,464,770
JBrowse link
G H2ax H2A.X variant histone increases expression
increases phosphorylation
multiple interactions
ISO Hydroxyurea results in increased expression of H2AX protein; Hydroxyurea results in increased expression of H2AX protein modified form
Hydroxyurea results in increased phosphorylation of H2AX protein
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased phosphorylation of H2AX protein]
CTD PMID:25125662, PMID:25130544, PMID:29228353, PMID:32482060 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hbp1 HMG-box transcription factor 1 decreases expression ISO Hydroxyurea results in decreased expression of HBP1 mRNA CTD PMID:24211769 NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625
JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions ISO Hydroxyurea promotes the reaction [Valproic Acid results in decreased expression of HDAC2 protein] CTD PMID:17653085 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hesx1 HESX homeobox 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of HESX1 gene CTD PMID:16868089 NCBI chr16:2,616,538...2,636,708
Ensembl chr16:2,634,603...2,636,708
JBrowse link
G Hoxb9 homeo box B9 decreases expression ISO Hydroxyurea results in decreased expression of HOXB9 mRNA CTD PMID:29990529 NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390
JBrowse link
G Hoxc6 homeo box C6 decreases expression ISO Hydroxyurea results in decreased expression of HOXC6 mRNA CTD PMID:29990529 NCBI chr 7:144,612,230...144,626,036
Ensembl chr 7:144,623,555...144,625,516
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO Hydroxyurea results in increased expression of HSPA8 mRNA CTD PMID:18647660 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Ier3 immediate early response 3 increases expression ISO Hydroxyurea results in increased expression of IER3 mRNA CTD PMID:12929121 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Il13 interleukin 13 affects expression ISO Hydroxyurea affects the expression of IL13 protein CTD PMID:15927844 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Isg20l2 interferon stimulated exonuclease gene 20-like 2 decreases expression ISO Hydroxyurea results in decreased expression of ISG20L2 mRNA CTD PMID:24211769 NCBI chr 2:187,302,192...187,311,677
Ensembl chr 2:187,302,192...187,311,676
JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 increases expression ISO Hydroxyurea results in increased expression of ITIH2 mRNA CTD PMID:12929121 NCBI chr17:72,160,734...72,197,248
Ensembl chr17:72,160,735...72,195,509
JBrowse link
G Kat2b lysine acetyltransferase 2B increases expression ISO Hydroxyurea results in increased expression of KAT2B mRNA CTD PMID:27208086 NCBI chr 9:4,440,982...4,492,949 JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO Hydroxyurea results in decreased expression of KIF20A mRNA CTD PMID:24211769 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814
JBrowse link
G Kif3b kinesin family member 3B increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of KIF3B gene CTD PMID:16868089 NCBI chr 3:148,772,937...148,813,342
Ensembl chr 3:148,773,259...148,813,293
JBrowse link
G Klrb1a killer cell lectin-like receptor subfamily B, member 1A increases expression ISO Hydroxyurea results in increased expression of KLRB1A mRNA CTD PMID:12929121 NCBI chr 4:161,950,270...161,966,582
Ensembl chr 4:161,949,817...162,025,187
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression ISO Hydroxyurea results in decreased expression of KPNA2 mRNA CTD PMID:17374387 NCBI chr10:95,200,029...95,212,111
Ensembl chr10:95,200,030...95,212,111
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases expression ISO Hydroxyurea results in decreased expression of KRAS mRNA CTD PMID:12929121 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Lhx2 LIM homeobox 2 decreases expression ISO Hydroxyurea results in decreased expression of LHX2 mRNA CTD PMID:24211769 NCBI chr 3:22,628,674...22,658,447
Ensembl chr 3:22,640,545...22,658,446
JBrowse link
G LOC102548695 zinc finger protein 45-like decreases expression ISO Hydroxyurea results in decreased expression of ZNF45 mRNA CTD PMID:24211769 NCBI chr 1:81,158,743...81,173,245
Ensembl chr 1:81,159,107...81,163,689
JBrowse link
G LOC683674 similar to Protein C7orf26 homolog decreases expression ISO Hydroxyurea results in decreased expression of C7ORF26 mRNA CTD PMID:24211769 NCBI chr12:13,299,651...13,313,733
Ensembl chr12:13,299,859...13,313,358
JBrowse link
G Lrrc47 leucine rich repeat containing 47 decreases expression ISO Hydroxyurea results in decreased expression of LRRC47 mRNA CTD PMID:24211769 NCBI chr 5:171,297,850...171,307,682
Ensembl chr 5:171,297,850...171,307,682
JBrowse link
G Ltb4r leukotriene B4 receptor increases expression ISO Hydroxyurea results in increased expression of LTB4R1 mRNA CTD PMID:27208086 NCBI chr15:34,449,299...34,453,352
Ensembl chr15:34,452,116...34,453,171
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO Hydroxyurea results in decreased expression of MAD2L1 mRNA CTD PMID:12929121 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of MAD2L2 gene CTD PMID:16868089 NCBI chr 5:164,943,183...164,956,255
Ensembl chr 5:164,950,917...164,956,255
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP Hydroxyurea results in decreased phosphorylation of MAPK1 protein CTD PMID:15557822 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP Hydroxyurea results in decreased phosphorylation of MAPK3 protein CTD PMID:15557822 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation EXP Hydroxyurea results in decreased phosphorylation of MAPK8 protein CTD PMID:15557822 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
affects expression
ISO Hydroxyurea results in increased expression of MDM2 mRNA
Hydroxyurea affects the expression of MDM2 protein
CTD PMID:16356682, PMID:18647660 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mecom MDS1 and EVI1 complex locus increases expression ISO Hydroxyurea results in increased expression of MECOM protein mutant form CTD PMID:16532439 NCBI chr 2:117,396,084...117,993,604
Ensembl chr 2:117,396,007...117,454,769
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression ISO Hydroxyurea results in increased expression of MGMT mRNA CTD PMID:12929121 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mipol1 mirror-image polydactyly 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of MIPOL1 gene CTD PMID:16868089 NCBI chr 6:78,172,842...78,506,232
Ensembl chr 6:78,172,790...78,499,599
JBrowse link
G Mpg N-methylpurine-DNA glycosylase increases expression ISO Hydroxyurea results in increased expression of MPG mRNA CTD PMID:12929121 NCBI chr10:15,661,768...15,667,995
Ensembl chr10:15,661,608...15,668,022
JBrowse link
G Mpzl1 myelin protein zero-like 1 decreases expression ISO Hydroxyurea results in decreased expression of MPZL1 mRNA CTD PMID:24211769 NCBI chr13:83,805,244...83,842,074
Ensembl chr13:83,805,244...83,842,051
JBrowse link
G Mrm2 mitochondrial rRNA methyltransferase 2 decreases expression ISO Hydroxyurea results in decreased expression of MRM2 mRNA CTD PMID:24211769 NCBI chr12:16,398,749...16,403,656
Ensembl chr12:16,398,749...16,403,656
JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO Hydroxyurea results in decreased expression of MSH6 mRNA CTD PMID:24211769 NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499
JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO Hydroxyurea results in decreased expression of MYB mRNA CTD PMID:12929121 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase decreases expression ISO Hydroxyurea results in decreased expression of NAMPT mRNA CTD PMID:12929121 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nek3 NIMA-related kinase 3 decreases expression ISO Hydroxyurea results in decreased expression of NEK3 mRNA CTD PMID:12929121 NCBI chr16:74,781,371...74,806,567
Ensembl chr16:74,785,281...74,806,149
JBrowse link
G Neurod4 neuronal differentiation 4 decreases expression ISO Hydroxyurea results in decreased expression of NEUROD4 mRNA CTD PMID:12929121 NCBI chr 7:9,699,964...9,712,067
Ensembl chr 7:9,699,961...9,711,928
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO Hydroxyurea results in increased expression of NFKB1 mRNA CTD PMID:18647660 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Hydroxyurea results in increased expression of NFKBIA mRNA CTD PMID:18647660 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nop58 NOP58 ribonucleoprotein decreases expression ISO Hydroxyurea results in decreased expression of NOL5 mRNA CTD PMID:12929121 NCBI chr 9:66,495,881...66,520,521
Ensembl chr 9:66,495,832...66,519,788
JBrowse link
G Nudt12 nudix hydrolase 12 increases expression ISO Hydroxyurea results in increased expression of NUDT12 mRNA CTD PMID:12929121 NCBI chr 9:105,680,603...105,693,374
Ensembl chr 9:105,680,670...105,693,357
JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit decreases expression ISO Hydroxyurea results in decreased expression of NUS1 mRNA CTD PMID:12929121 NCBI chr20:33,557,052...33,584,011
Ensembl chr20:33,557,052...33,584,010
JBrowse link
G P2ry6 pyrimidinergic receptor P2Y6 increases expression ISO Hydroxyurea results in increased expression of P2RY6 mRNA CTD PMID:27208086 NCBI chr 1:165,972,439...166,008,348
Ensembl chr 1:165,972,440...165,997,751
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Hydroxyurea results in increased expression of PCNA mRNA CTD PMID:18647660 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pelo pelota mRNA surveillance and ribosome rescue factor decreases expression ISO Hydroxyurea results in decreased expression of PELO mRNA CTD PMID:24211769 NCBI chr 2:47,266,758...47,268,526
Ensembl chr 2:47,266,738...47,268,625
JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression ISO Hydroxyurea results in increased expression of PERP mRNA CTD PMID:27208086 NCBI chr 1:14,224,392...14,236,838
Ensembl chr 1:14,224,393...14,236,846
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO Hydroxyurea results in increased expression of PHLDA3 mRNA CTD PMID:24211769 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
JBrowse link
G Pidd1 p53-induced death domain protein 1 increases expression ISO Hydroxyurea results in increased expression of PIDD1 mRNA CTD PMID:27208086 NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881
JBrowse link
G Pklr pyruvate kinase L/R decreases expression ISO Hydroxyurea results in decreased expression of PKLR mRNA CTD PMID:12929121 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of PMAIP1 mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of PMAIP1 mRNA]
CTD PMID:27208086, PMID:29228353 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Pml PML nuclear body scaffold increases expression ISO Hydroxyurea results in increased expression of PML mRNA CTD PMID:27208086 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Polh DNA polymerase eta increases expression ISO Hydroxyurea results in increased expression of POLH mRNA CTD PMID:25125662 NCBI chr 9:17,163,354...17,198,006
Ensembl chr 9:17,163,354...17,197,132
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D increases expression ISO Hydroxyurea results in increased expression of PPM1D mRNA CTD PMID:24211769 NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A decreases expression ISO Hydroxyurea results in decreased expression of PPP1R12A mRNA CTD PMID:12929121 NCBI chr 7:51,404,971...51,515,382
Ensembl chr 7:51,404,919...51,515,373
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Hydroxyurea results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 increases expression ISO Hydroxyurea results in increased expression of PRKAB1 mRNA CTD PMID:24211769 NCBI chr12:46,316,298...46,326,789
Ensembl chr12:46,316,236...46,326,790
JBrowse link
G Prrg4 proline rich and Gla domain 4 increases expression ISO Hydroxyurea results in increased expression of PRRG4 mRNA CTD PMID:27208086 NCBI chr 3:94,783,866...94,808,861
Ensembl chr 3:94,784,008...94,808,861
JBrowse link
G Prune1 prune exopolyphosphatase 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of PRUNE1 gene CTD PMID:16868089 NCBI chr 2:196,427,714...196,457,105
Ensembl chr 2:196,427,710...196,456,481
JBrowse link
G Psip1 PC4 and SFRS1 interacting protein 1 decreases expression ISO Hydroxyurea results in decreased expression of PSIP1 mRNA CTD PMID:12929121 NCBI chr 5:101,555,691...101,588,659
Ensembl chr 5:101,555,694...101,588,598
JBrowse link
G Psrc1 proline and serine rich coiled-coil 1 decreases expression ISO Hydroxyurea results in decreased expression of PSRC1 mRNA CTD PMID:17374387 NCBI chr 2:211,176,437...211,181,078
Ensembl chr 2:211,176,556...211,181,123
JBrowse link
G Pus3 pseudouridine synthase 3 decreases expression ISO Hydroxyurea results in decreased expression of PUS3 mRNA CTD PMID:24211769 NCBI chr 8:36,760,874...36,769,167
Ensembl chr 8:36,766,977...36,769,162
JBrowse link
G Rab34 RAB34, member RAS oncogene family increases expression ISO Hydroxyurea results in increased expression of RAB34 mRNA CTD PMID:12929121 NCBI chr10:65,448,111...65,452,178
Ensembl chr10:65,448,950...65,452,177
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO Hydroxyurea results in decreased expression of RAD23A mRNA CTD PMID:12929121 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391
JBrowse link
G Rad51c RAD51 paralog C increases expression ISO Hydroxyurea results in increased expression of RAD51C mRNA CTD PMID:27825931 NCBI chr10:74,697,713...74,724,004
Ensembl chr10:74,697,716...74,724,472
JBrowse link
G Ran RAN, member RAS oncogene family decreases expression ISO Hydroxyurea results in decreased expression of RAN mRNA CTD PMID:12929121 NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810
JBrowse link
G Rap2b RAP2B, member of RAS oncogene family decreases expression ISO Hydroxyurea results in decreased expression of RAP2B mRNA CTD PMID:24211769 NCBI chr 2:151,685,251...151,685,802
Ensembl chr 2:151,685,251...151,685,802
JBrowse link
G Rara retinoic acid receptor, alpha increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of RARA gene CTD PMID:16868089 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of RB1 mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of RB1 mRNA]
CTD PMID:27208086, PMID:29228353 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbm4 RNA binding motif protein 4 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of RBM4 gene CTD PMID:16868089 NCBI chr 1:220,038,403...220,049,756
Ensembl chr 1:220,039,734...220,048,966
JBrowse link
G Rfx4 regulatory factor X4 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of RFX4 gene CTD PMID:16868089 NCBI chr 7:25,831,358...25,909,976
Ensembl chr 7:25,808,419...25,907,849
JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO Hydroxyurea results in increased expression of RGS16 mRNA CTD PMID:24211769 NCBI chr13:71,163,411...71,185,147
Ensembl chr13:71,179,910...71,185,216
JBrowse link
G Rnf113a1 ring finger protein 113A1 decreases expression ISO Hydroxyurea results in decreased expression of RNF113A mRNA CTD PMID:24211769 NCBI chr  X:123,806,922...123,808,049
Ensembl chr  X:124,516,949...124,518,077
JBrowse link
G Rnf19a ring finger protein 19A, RBR E3 ubiquitin protein ligase decreases expression ISO Hydroxyurea results in decreased expression of RNF19A mRNA CTD PMID:12929121 NCBI chr 7:75,058,758...75,098,331
Ensembl chr 7:75,058,758...75,098,331
JBrowse link
G Rnf4 ring finger protein 4 decreases response to substance EXP RNF4 protein results in decreased susceptibility to Hydroxyurea CTD PMID:22661230 NCBI chr14:81,658,400...81,679,756
Ensembl chr14:81,660,354...81,679,082
JBrowse link
G Rpl22l1 ribosomal protein L22 like 1 decreases expression ISO Hydroxyurea results in decreased expression of RPL22L1 mRNA CTD PMID:12929121 NCBI chr 2:115,362,799...115,364,735
Ensembl chr 2:115,362,799...115,364,729
JBrowse link
G Rras RAS related increases expression ISO Hydroxyurea results in increased expression of RRAS mRNA CTD PMID:12929121 NCBI chr 1:101,012,822...101,016,720
Ensembl chr 1:101,012,822...101,016,720
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases activity ISO Hydroxyurea results in decreased activity of RRM2 protein CTD PMID:22403396 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO Hydroxyurea results in increased expression of RRM2B mRNA CTD PMID:18647660 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817
JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression ISO Hydroxyurea results in increased expression of RUNX1 protein mutant form CTD PMID:16532439 NCBI chr11:32,765,147...33,003,061
Ensembl chr11:32,769,165...33,003,021
JBrowse link
G Runx2 RUNX family transcription factor 2 affects expression ISO Hydroxyurea affects the expression of RUNX2 mRNA CTD PMID:24704097 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sesn1 sestrin 1 increases expression ISO Hydroxyurea results in increased expression of SESN1 mRNA CTD PMID:24211769 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Hydroxyurea results in increased expression of SGK1 mRNA CTD PMID:18647660 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Slbp stem-loop binding protein decreases expression ISO Hydroxyurea results in decreased expression of SLBP mRNA CTD PMID:24211769 NCBI chr14:82,356,916...82,366,368
Ensembl chr14:82,356,916...82,366,368
JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) affects transport
increases uptake
ISO SLC14A1 protein affects the transport of Hydroxyurea
SLC14A1 protein results in increased uptake of Hydroxyurea
CTD PMID:17506977, PMID:21256917 NCBI chr18:74,461,064...74,504,475
Ensembl chr18:74,461,055...74,485,139
JBrowse link
G Slc14a2 solute carrier family 14 member 2 increases uptake ISO SLC14A2 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr18:74,508,070...74,941,389
Ensembl chr18:74,546,220...74,688,551
Ensembl chr18:74,546,220...74,688,551
JBrowse link
G Slc16a12 solute carrier family 16, member 12 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of SLC16A12 gene CTD PMID:16868089 NCBI chr 1:252,976,071...253,054,500
Ensembl chr 1:252,976,644...253,000,760
JBrowse link
G Slc1a5 solute carrier family 1 member 5 decreases expression ISO Hydroxyurea results in decreased expression of SLC1A5 mRNA CTD PMID:24211769 NCBI chr 1:78,710,686...78,724,789
Ensembl chr 1:78,710,539...78,724,794
JBrowse link
G Slc22a4 solute carrier family 22 member 4 increases uptake ISO SLC22A4 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases uptake ISO SLC22A5 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases uptake ISO SLCO1A2 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases uptake
ISO naringin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea] CTD PMID:21256917 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Snca synuclein alpha multiple interactions ISO Hydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to ferrous chloride]; Hydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to Iron] CTD PMID:14535945 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Spink4 serine peptidase inhibitor, Kazal type 4 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of SPINK4 gene CTD PMID:16868089 NCBI chr 5:57,238,221...57,252,654
Ensembl chr 5:57,239,086...57,250,662
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Hydroxyurea results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stk4 serine/threonine kinase 4 increases cleavage
multiple interactions
ISO Hydroxyurea results in increased cleavage of STK4 protein
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of STK4 protein]
CTD PMID:29228353 NCBI chr 3:160,467,552...160,546,540
Ensembl chr 3:160,467,552...160,546,540
JBrowse link
G Svop SV2 related protein increases expression ISO Hydroxyurea results in increased expression of SVOP mRNA CTD PMID:27208086 NCBI chr12:48,292,272...48,351,974
Ensembl chr12:48,292,273...48,351,084
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression ISO Hydroxyurea results in increased expression of TAP1 mRNA CTD PMID:27208086 NCBI chr20:3,979,302...3,989,669
Ensembl chr20:3,979,035...3,989,669
JBrowse link
G Tbpl1 TATA-box binding protein like 1 affects localization ISO Hydroxyurea affects the localization of TBPL1 protein CTD PMID:17085973 NCBI chr 1:23,977,154...24,002,512
Ensembl chr 1:23,977,688...24,002,506
JBrowse link
G Tbx6 T-box transcription factor 6 decreases expression ISO Hydroxyurea results in decreased expression of TBX6 mRNA CTD PMID:29990529 NCBI chr 1:198,214,797...198,218,706
Ensembl chr 1:198,214,797...198,218,706
JBrowse link
G Tfec transcription factor EC decreases expression ISO Hydroxyurea results in decreased expression of TFEC mRNA CTD PMID:24211769 NCBI chr 4:44,063,533...44,136,815
Ensembl chr 4:44,065,045...44,136,815
JBrowse link
G Tipin timeless interacting protein decreases expression ISO Hydroxyurea results in decreased expression of TIPIN mRNA CTD PMID:24211769 NCBI chr 8:69,753,363...69,768,640
Ensembl chr 8:69,753,373...69,768,305
JBrowse link
G Tmem185b transmembrane protein 185B decreases expression ISO Hydroxyurea results in decreased expression of TMEM185B mRNA CTD PMID:24211769 NCBI chr13:35,554,621...35,557,952
Ensembl chr13:35,554,964...35,556,016
JBrowse link
G Tmem69 transmembrane protein 69 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of TMEM69 gene CTD PMID:16868089 NCBI chr 5:135,394,013...135,397,591
Ensembl chr 5:135,394,016...135,397,591
JBrowse link
G Tnf tumor necrosis factor increases secretion ISO Hydroxyurea results in increased secretion of TNF protein CTD PMID:14965870 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO Hydroxyurea results in increased expression of TNFRSF10A mRNA CTD PMID:27208086 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Top1 DNA topoisomerase I decreases expression ISO Hydroxyurea results in decreased expression of TOP1 mRNA CTD PMID:12929121 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Tor1a torsin family 1, member A decreases expression ISO Hydroxyurea results in decreased expression of TOR1A mRNA CTD PMID:24211769 NCBI chr 3:9,800,322...9,807,318
Ensembl chr 3:9,800,322...9,807,328
JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects response to substance
increases expression
ISO Hydroxyurea results in increased expression of and results in increased phosphorylation of TRP53 protein; Hydroxyurea results in increased phosphorylation of and results in increased activity of and affects the localization of TRP53 protein; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of STK4 protein]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of CDKN1A mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of FAS mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of PMAIP1 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of RB1 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP53INP1 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP73 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased phosphorylation of H2AX protein]
TRP53 affects the susceptibility to Hydroxyurea
Hydroxyurea results in increased expression of TP53 protein; Hydroxyurea results in increased expression of TP53 protein modified form
CTD PMID:10978678, PMID:16005713, PMID:16356682, PMID:21840268, PMID:25125662, PMID:27208086, PMID:29228353 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of TRP53INP1 mRNA; Hydroxyurea results in increased expression of TRP53INP1 protein
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP53INP1 mRNA]
CTD PMID:27208086, PMID:29228353 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Tp63 tumor protein p63 decreases expression ISO Hydroxyurea results in decreased expression of TRP63 mRNA CTD PMID:29228353 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Tp73 tumor protein p73 increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of TRP73 mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP73 mRNA]
CTD PMID:29228353 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Tpp2 tripeptidyl peptidase 2 affects localization ISO Hydroxyurea affects the localization of TPP2 protein CTD PMID:20643100 NCBI chr 9:50,664,048...50,744,803
NCBI chr 9:50,578,868...50,628,943
Ensembl chr 9:50,581,234...50,744,803
JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO Hydroxyurea promotes the reaction [Valproic Acid results in increased expression of TRADD protein] CTD PMID:17653085 NCBI chr19:37,214,461...37,221,099
Ensembl chr19:37,214,471...37,216,572
JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 increases expression ISO Hydroxyurea results in increased expression of TRIAP1 mRNA CTD PMID:18647660 NCBI chr12:46,987,404...46,989,906
Ensembl chr12:46,987,404...46,989,897
Ensembl chr12:46,987,404...46,989,897
JBrowse link
G Trim32 tripartite motif-containing 32 decreases expression ISO Hydroxyurea results in decreased expression of TRIM32 mRNA CTD PMID:24211769 NCBI chr 5:81,431,554...81,449,023
Ensembl chr 5:81,431,600...81,442,451
JBrowse link
G Trim38 tripartite motif containing 38 decreases expression ISO Hydroxyurea results in decreased expression of TRIM38 mRNA CTD PMID:24211769 NCBI chr17:43,600,006...43,607,879 JBrowse link
G Trim68 tripartite motif containing 68 increases expression ISO Hydroxyurea results in increased expression of TRIM68 mRNA CTD PMID:12929121 NCBI chr 1:167,835,773...167,849,880
Ensembl chr 1:167,835,647...167,849,834
JBrowse link
G Ubac2 UBA domain containing 2 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of UBAC2 gene CTD PMID:16868089 NCBI chr15:108,286,407...108,433,531
Ensembl chr15:108,286,453...108,433,529
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO Hydroxyurea results in decreased expression of UBE2C mRNA CTD PMID:17374387 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Utp3 UTP3, small subunit processome component decreases expression ISO Hydroxyurea results in decreased expression of UTP3 mRNA CTD PMID:24211769 NCBI chr14:21,153,998...21,155,652
Ensembl chr14:21,154,000...21,155,652
JBrowse link
G Wnt3a Wnt family member 3A decreases expression ISO Hydroxyurea results in decreased expression of WNT3A mRNA CTD PMID:29990529 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor increases expression ISO Hydroxyurea results in increased expression of XPC mRNA CTD PMID:18647660 NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases response to substance ISO XRCC4 results in decreased susceptibility to Hydroxyurea CTD PMID:21785230 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression
increases mutagenesis
ISO Hydroxyurea results in decreased expression of XRCC5 mRNA
Hydroxyurea results in increased mutagenesis of XRCC5 gene
CTD PMID:12929121, PMID:16868089 NCBI chr 9:79,659,275...79,748,050
Ensembl chr 9:79,659,251...79,748,078
JBrowse link
G Zbtb24 zinc finger and BTB domain containing 24 decreases expression ISO Hydroxyurea results in decreased expression of ZBTB24 mRNA CTD PMID:24211769 NCBI chr20:46,168,149...46,189,806
Ensembl chr20:46,168,177...46,189,806
JBrowse link
G Zfp365 zinc finger protein 365 increases expression ISO Hydroxyurea results in increased expression of ZFP365 mRNA CTD PMID:27208086 NCBI chr20:22,060,160...22,083,766
Ensembl chr20:22,060,224...22,086,108
JBrowse link
G Zfp385a zinc finger protein 385A increases expression ISO Hydroxyurea results in increased expression of ZFP385A mRNA CTD PMID:12929121 NCBI chr 7:144,939,616...144,966,364
Ensembl chr 7:144,939,619...144,966,370
JBrowse link
G Znf750 zinc finger protein 750 increases expression ISO Hydroxyurea results in increased expression of ZFP750 mRNA CTD PMID:27208086 NCBI chr10:110,698,581...110,701,222
Ensembl chr10:110,698,891...110,701,137
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        immunomodulator 13691
          hydroxyurea 214
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  urea 4984
                                                    ureas 4982
                                                      hydroxyurea 214
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.