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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lawsone
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Accession:CHEBI:44401 term browser browse the term
Definition:1,4-Naphthoquinone carrying a hydroxy function at C-2. It is obtained from the leaves of Lawsonia inermis.
Synonyms:related_synonym: 2-HYDROXYNAPHTHOQUINONE;   2-hydroxy-1,4-naphthalenedione;   2-hydroxy-1,4-naphthoquinone;   2-hydroxynaphthalene-1,4-dione;   Formula=C10H6O3;   Henna;   InChI=1S/C10H6O3/c11-8-5-9(12)10(13)7-4-2-1-3-6(7)8/h1-5,12H;   InChIKey=CSFWPUWCSPOLJW-UHFFFAOYSA-N;   SMILES=OC1=CC(=O)c2ccccc2C1=O
 alt_id: CHEBI:44399;   CHEBI:6395
 xref: Beilstein:1565260;   CAS:83-72-7;   Gmelin:4828;   KEGG:C10368;   KNApSAcK:C00002837
 xref_mesh: MESH:C005090
 xref: PDBeChem:NQ
 cyclic_relationship: is_tautomer_of CHEBI:93166


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lawsone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO lawsone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity ISO
EXP		 lawsone results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654 		JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO lawsone results in decreased expression of MITF protein CTD PMID:25584612 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression ISO lawsone results in decreased expression of NFE2L2 mRNA CTD PMID:31967339 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP lawsone results in increased activity of NQO1 protein CTD PMID:17265417 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Tyr tyrosinase multiple interactions ISO lawsone results in decreased expression of and results in decreased activity of TYR protein CTD PMID:25584612 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      biological role 20023
        antimicrobial agent 17788
          antifungal agent 16084
            lawsone 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            organic group 18965
                              organic divalent group 18951
                                organodiyl group 18951
                                  carbonyl group 18903
                                    carbonyl compound 18903
                                      ketone 17111
                                        cyclic ketone 15664
                                          quinone 8523
                                            naphthoquinone 1446
                                              1,4-naphthoquinones 1433
                                                hydroxy-1,4-naphthoquinone 131
                                                  lawsone 6
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