CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: lawsone
Accession: CHEBI:44401
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Definition: 1,4-Naphthoquinone carrying a hydroxy function at C-2. It is obtained from the leaves of Lawsonia inermis.
Synonyms: related_synonym: 2-HYDROXYNAPHTHOQUINONE; 2-hydroxy-1,4-naphthalenedione; 2-hydroxy-1,4-naphthoquinone; 2-hydroxynaphthalene-1,4-dione; Formula=C10H6O3; Henna; InChI=1S/C10H6O3/c11-8-5-9(12)10(13)7-4-2-1-3-6(7)8/h1-5,12H; InChIKey=CSFWPUWCSPOLJW-UHFFFAOYSA-N; SMILES=OC1=CC(=O)c2ccccc2C1=O
alt_id: CHEBI:44399; CHEBI:6395
xref: Beilstein:1565260; CAS:83-72-7; Gmelin:4828; KEGG:C10368; KNApSAcK:C00002837
xref_mesh: MESH:C005090
xref: PDBeChem:NQ
cyclic_relationship: is_tautomer_of CHEBI:93166
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
lawsone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD
PMID:19269596
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
G
Dhodh
dihydroorotate dehydrogenase (quinone)
decreases activity
ISO EXP
lawsone results in decreased activity of DHODH protein
CTD
PMID:10658902
NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
G
Mitf
melanocyte inducing transcription factor
decreases expression
ISO
lawsone results in decreased expression of MITF protein
CTD
PMID:25584612
NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
G
Nqo1
NAD(P)H quinone dehydrogenase 1
increases activity
EXP
lawsone results in increased activity of NQO1 protein
CTD
PMID:17265417
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
G
Tyr
tyrosinase
multiple interactions
ISO
lawsone results in decreased expression of and results in decreased activity of TYR protein
CTD
PMID:25584612
NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
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