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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:duvoglustat
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Accession:CHEBI:44369 term browser browse the term
Definition:An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.
Synonyms:exact_synonym: (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
 related_synonym: 1,5-deoxy-1,5-imino-D-mannitol;   1,5-dideoxy-1,5-imino-D-glucitol;   1-DEOXYNOJIRIMYCIN;   1-Deoxymannojirimycin;   5-amino-1,5-dideoxy-D-glucopyranose;   BAY-H-5595;   D-1-deoxynojirimycin;   DNJ;   Formula=C6H13NO4;   InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1;   InChIKey=LXBIFEVIBLOUGU-JGWLITMVSA-N;   Moranolin;   Moranoline;   SMILES=OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
 alt_id: CHEBI:132398;   CHEBI:132867;   CHEBI:76525
 xref: CAS:19130-96-2;   DrugBank:DB03206;   HMDB:HMDB0035359;   KEGG:C16843;   KEGG:D09605;   KNApSAcK:C00029420
 xref_mesh: MESH:D017485
 xref: MetaCyc:1-DEOXYNOJIRIMYCIN;   PDBeChem:NOJ;   PMID:23265519;   PMID:23391926;   PMID:23536174;   PMID:23561072;   PMID:23570294;   PMID:23648852;   PMID:23755289;   PMID:23909841;   PMID:24050301;   PMID:26292150;   PMID:26867190;   PMID:26927057;   PMID:27160849;   PMID:27294120;   Reaxys:1524395;   Wikipedia:1-Deoxynojirimycin



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duvoglustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions EXP 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA] CTD PMID:25445511 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
JBrowse link
G App amyloid beta precursor protein decreases response to substance EXP 1-Deoxynojirimycin results in decreased susceptibility to APP protein CTD PMID:19028522 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 1-Deoxynojirimycin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; 1-Deoxynojirimycin inhibits the reaction [Tunicamycin results in increased activity of CASP3 protein] CTD PMID:19028522 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cd36 CD36 molecule multiple interactions EXP 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of CD36 mRNA] CTD PMID:25445511 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of CEBPA mRNA] CTD PMID:25445511 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO 1-Deoxynojirimycin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; 1-Deoxynojirimycin inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein] CTD PMID:19028522 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA] CTD PMID:25445511 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Fbp2 fructose bisphosphatase 2 multiple interactions EXP [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of FBP2 protein] CTD PMID:25446853 NCBI chr13:62,984,698...63,006,214
Ensembl chr13:62,984,691...63,006,236
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of G6PC1 protein] CTD PMID:25446853 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729
JBrowse link
G Gck glucokinase multiple interactions EXP [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCK protein] CTD PMID:25446853 NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:25445511 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Ins1 insulin I multiple interactions EXP [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of and results in decreased secretion of INS1 protein] CTD PMID:25446853 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Insr insulin receptor multiple interactions EXP [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein] CTD PMID:25446853 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617
JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of LPL mRNA] CTD PMID:25446853 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic multiple interactions EXP [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PCK1 protein] CTD PMID:25446853 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066
JBrowse link
G Pcx pyruvate carboxylase multiple interactions EXP [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PCX protein] CTD PMID:25446853 NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 multiple interactions EXP [1-Deoxynojirimycin co-treated with Polysaccharides] results in increased expression of PDHA1 mRNA CTD PMID:25446853 NCBI chr  X:158,905,215...158,921,426
Ensembl chr  X:158,905,205...158,921,409
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 multiple interactions EXP [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PDK1 mRNA] CTD PMID:25446853 NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202
JBrowse link
G Pfkp phosphofructokinase, platelet multiple interactions EXP [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PFKP protein] CTD PMID:25446853 NCBI chr13:6,629,910...6,699,096
Ensembl chr13:6,629,804...6,698,813
JBrowse link
G Pklr pyruvate kinase liver and red blood cell multiple interactions EXP [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PKLR protein] CTD PMID:25446853 NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091
JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta multiple interactions EXP [1-Deoxynojirimycin co-treated with Dietary Fats] results in increased expression of PPARGC1B mRNA CTD PMID:25445511 NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502
JBrowse link
miglustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions EXP miglustat inhibits the reaction [ST8SIA1 protein results in increased expression of BCL2 protein] CTD PMID:11574545 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Canx calnexin multiple interactions ISO miglustat inhibits the reaction [CANX protein binds to CFTR protein mutant form] CTD PMID:18230692 NCBI chr11:50,184,784...50,216,500
Ensembl chr11:50,184,788...50,216,500
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions
increases activity
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [miglustat results in increased activity of CFTR protein mutant form]; Brefeldin A inhibits the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [miglustat results in increased activity of CFTR protein mutant form]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form]; miglustat inhibits the reaction [CANX protein binds to CFTR protein mutant form]; miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; Thapsigargin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] CTD PMID:18230692 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767
JBrowse link
G Pawr PRKC, apoptosis, WT1, regulator multiple interactions EXP miglustat inhibits the reaction [[ST8SIA1 protein affects the abundance of Gangliosides] which results in decreased expression of PAWR protein] CTD PMID:11574545 NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101
JBrowse link
G St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 multiple interactions EXP miglustat inhibits the reaction [[ST8SIA1 protein affects the abundance of Gangliosides] which results in decreased expression of PAWR protein]; miglustat inhibits the reaction [ST8SIA1 protein results in increased expression of BCL2 protein] CTD PMID:11574545 NCBI chr 6:142,767,267...142,935,247
Ensembl chr 6:142,767,271...142,910,178
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase multiple interactions EXP [miglustat results in decreased activity of UGCG protein] which results in decreased abundance of Gangliosides; [miglustat results in decreased activity of UGCG protein] which results in decreased abundance of Glucosylceramides CTD PMID:10037475 NCBI chr 4:59,189,452...59,222,833
Ensembl chr 4:59,189,257...59,222,833
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        pharmacological role 19771
          anti-obesity agent 484
            duvoglustat 27
              1-deoxynojirimycin-1-sulfonic acid 0
              4-O-alpha-D-glucopyranosylmoranoline 0
              N-ethyl-1-deoxynojirimycin 0
              N-methyl-1-deoxynojirimycin 0
              N-nonyldeoxynojirimycin 0
              miglustat 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic heterocyclic compound 20352
                                  organic heteromonocyclic compound 18733
                                    piperidines 7828
                                      hydroxypiperidine 653
                                        2-(hydroxymethyl)piperidine-3,4,5-triol 27
                                          duvoglustat 27
                                            1-deoxynojirimycin-1-sulfonic acid 0
                                            4-O-alpha-D-glucopyranosylmoranoline 0
                                            N-ethyl-1-deoxynojirimycin 0
                                            N-methyl-1-deoxynojirimycin 0
                                            N-nonyldeoxynojirimycin 0
                                            miglustat 6
paths to the root