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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetraethylammonium
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Accession:CHEBI:44296 term browser browse the term
Definition:A quaternary ammonium ion that has formula C8H20N.
Synonyms:related_synonym: Formula=C8H20N;   InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1;   InChIKey=CBXCPBUEXACCNR-UHFFFAOYSA-N;   N,N,N-triethylethanaminium;   NEt4(+);   SMILES=CC[N+](CC)(CC)CC;   TETRAETHYLAMMONIUM ION;   tetraethylazanium
 alt_id: CHEBI:44295;   CHEBI:9478
 xref: Beilstein:1738225;   CAS:66-40-0;   KEGG:C07512
 xref_mesh: MESH:D019789
 xref: PDBeChem:NET


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tetraethylammonium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP1 aquaporin 1 (Colton blood group) decreases activity EXP Tetraethylammonium results in decreased activity of AQP1 protein CTD PMID:10779387 NCBI chr 7:30,911,853...30,925,516
Ensembl chr 7:30,911,853...30,925,517 		JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP Tetraethylammonium results in decreased activity of BCHE protein CTD PMID:31173753 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462 		JBrowse link
G CRH corticotropin releasing hormone multiple interactions ISO Tetraethylammonium promotes the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone] CTD PMID:18835572 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 increases phosphorylation ISO Tetraethylammonium increases phosphorylation of Gria1 protein in the hippocampal projection RGD PMID:24884762 RGD:405650199 NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869 		JBrowse link
G KCNA1 potassium voltage-gated channel subfamily A member 1 increases response to substance
multiple interactions
affects binding
affects response to substance		 ISO
EXP		 KCNA1 protein results in increased susceptibility to Tetraethylammonium
Tetraethylammonium inhibits the reaction [Scorpion Venoms binds to KCNA1 protein]
Tetraethylammonium binds to KCNA1 protein
KCNA1 protein affects the susceptibility to Tetraethylammonium		 CTD PMID:12700677 PMID:15100162 PMID:25792741 NCBI chr12:4,909,905...4,918,256
Ensembl chr12:4,909,905...4,918,256 		JBrowse link
G KCNMA1 potassium calcium-activated channel subfamily M alpha 1 multiple interactions EXP Tetraethylammonium inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]; Tetraethylammonium inhibits the reaction [estradiol-bovine serum albumin results in increased activity of KCNMA1 protein]; Tetraethylammonium promotes the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]]; Tetraethylammonium results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein] CTD PMID:18068743 PMID:21413024 NCBI chr10:76,869,602...77,637,808
Ensembl chr10:76,869,601...77,638,369 		JBrowse link
G KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 multiple interactions EXP Tetraethylammonium promotes the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]]; Tetraethylammonium results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein] CTD PMID:21413024 NCBI chr 5:170,374,671...170,389,367
Ensembl chr 5:170,374,671...170,389,634 		JBrowse link
G KCNN4 potassium calcium-activated channel subfamily N member 4 multiple interactions EXP [Ionomycin co-treated with Tetraethylammonium] results in increased activity of KCNN4 protein; Clotrimazole inhibits the reaction [[Ionomycin co-treated with Tetraethylammonium] results in increased activity of KCNN4 protein] CTD PMID:14985237 NCBI chr19:43,766,533...43,780,973
Ensembl chr19:43,766,533...43,780,976 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation ISO Tetraethylammonium results in increased phosphorylation of MAPK1 protein CTD PMID:35137321 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation ISO Tetraethylammonium results in increased phosphorylation of MAPK3 protein CTD PMID:35137321 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions
increases import
increases uptake
affects transport		 ISO
EXP		 1-Methyl-4-phenylpyridinium affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Chlorpheniramine affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Disopyramide affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Dopamine affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Progesterone inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A1 protein results in increased import of Tetraethylammonium; SLC22A1 results in increased import of Tetraethylammonium
3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; 4-biphenylamine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; bisphenol A inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; bisphenol F inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; bisphenol S promotes the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Nicotine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; tetrabromobisphenol A inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]; Tobacco Smoke Pollution inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]
SLC22A1 protein affects the transport of Tetraethylammonium		 CTD PMID:9260930 PMID:9830022 PMID:12440152 PMID:16006492 PMID:16141367 More... NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718 		JBrowse link
G SLC22A16 solute carrier family 22 member 16 multiple interactions
increases uptake		 EXP [Tetraethylammonium results in decreased activity of SLC22A16 protein] which results in decreased susceptibility to Doxorubicin; Dopamine inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]; Guanidine inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]; Lidocaine inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]; N(1)-methylnicotinamide inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]; Procainamide inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]; Serotonin inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium] CTD PMID:15963465 NCBI chr 6:110,424,687...110,476,613
Ensembl chr 6:110,424,687...110,476,641 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions
increases uptake
decreases uptake
increases import
affects transport		 EXP
ISO		 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; [Mercuric Chloride results in decreased activity of SLC22A2 protein] which results in decreased uptake of Tetraethylammonium; Aconitine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; bisphenol F promotes the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; bisphenol S promotes the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Chlorpyrifos inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Cimetidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Famotidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Fenitrothion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Haloperidol inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Lidocaine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Malathion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Mianserin inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Nicotine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; tetrabromobisphenol A inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Tetraethylammonium inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Tetraethylammonium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Tobacco Smoke Pollution inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; Triazolam inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
SLC22A2 gene polymorphism results in decreased uptake of Tetraethylammonium
SLC22A2 protein results in increased import of Tetraethylammonium; SLC22A2 results in increased import of Tetraethylammonium
1-Methyl-4-phenylpyridinium affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Chlorpheniramine affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Corticosterone inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Desoxycorticosterone inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Disopyramide affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Dopamine affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Estradiol affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Progesterone inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Testosterone inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]		 CTD PMID:9260930 PMID:9830022 PMID:12440152 PMID:15496291 PMID:16006492 More... NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SLC22A3 solute carrier family 22 member 3 multiple interactions
increases uptake		 EXP
ISO		 Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]; Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; 1-Methyl-4-phenylpyridinium analog inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; 5-dimethylamiloride inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Barium inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Guanidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; N(1)-methylnicotinamide inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Potassium inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Desoxycorticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Dopamine affects the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Estradiol inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Norepinephrine affects the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Progesterone inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Testosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]		 CTD PMID:9830022 PMID:10966924 PMID:16141367 PMID:19357179 PMID:21256917 NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577 		JBrowse link
G SLC22A4 solute carrier family 22 member 4 multiple interactions
increases uptake
increases transport		 EXP Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Carvedilol inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Diltiazem inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Flecainide inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Ipratropium inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Lidocaine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Nifedipine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Propafenone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Propranolol inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Spironolactone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Verapamil inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]
SLC22A4 protein results in increased transport of Tetraethylammonium		 CTD PMID:21641380 PMID:25490951 PMID:27504015 NCBI chr 5:132,294,394...132,344,190
Ensembl chr 5:132,294,394...132,344,190 		JBrowse link
G SLC22A5 solute carrier family 22 member 5 multiple interactions
increases uptake		 ISO 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A5 protein results in increased uptake of Tetraethylammonium]; Carnitine inhibits the reaction [SLC22A5 protein results in increased uptake of Tetraethylammonium]; Tetraethylammonium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:12644265 NCBI chr 5:132,369,710...132,395,612
Ensembl chr 5:132,369,710...132,395,613 		JBrowse link
G SLC47A1 solute carrier family 47 member 1 affects transport
multiple interactions
increases import
increases uptake
decreases uptake		 EXP
ISO		 SLC47A1 protein affects the transport of Tetraethylammonium
Tetraethylammonium inhibits the reaction [SLC47A1 protein affects the uptake of Paraquat]
SLC47A1 protein results in increased import of Tetraethylammonium
bisphenol A inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium]; bisphenol F inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium]; bisphenol S inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium]; Pyrimethamine inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium]; tetrabromobisphenol A inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium]; Tetraethylammonium inhibits the reaction [SLC47A1 protein affects the uptake of Paraquat]; Tetraethylammonium inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Tobacco Smoke Pollution inhibits the reaction [SLC47A1 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC47A1 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium]
SLC47A1 protein polymorphism results in decreased uptake of Tetraethylammonium		 CTD PMID:16928787 PMID:17495125 PMID:19172157 PMID:22419765 PMID:27450509 More... NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034 		JBrowse link
G SLC47A2 solute carrier family 47 member 2 increases uptake
increases import
multiple interactions		 EXP SLC47A2 protein results in increased uptake of Tetraethylammonium
SLC47A2 protein results in increased import of Tetraethylammonium
Amitriptyline inhibits the reaction [SLC47A2 protein results in increased import of Tetraethylammonium]; Pyrimethamine inhibits the reaction [SLC47A2 protein results in increased uptake of Tetraethylammonium]; Tetraethylammonium inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Tobacco Smoke Pollution inhibits the reaction [SLC47A2 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC47A2 protein results in increased uptake of Tetraethylammonium]		 CTD PMID:22419765 PMID:27989701 PMID:28629854 PMID:32305507 NCBI chr17:19,678,317...19,718,979
Ensembl chr17:19,678,288...19,718,979 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    chemical entity 26024
      molecular entity 25991
        ion 18767
          organic ion 10222
            organic cation 9152
              quaternary ammonium ion 5365
                tetraethylammonium 17
                  tetraethylammonium chloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    main group molecular entity 25834
                      s-block molecular entity 25166
                        hydrogen molecular entity 24765
                          hydrides 22965
                            inorganic hydride 20483
                              pnictogen hydride 20424
                                nitrogen hydride 20200
                                  ammonium 8184
                                    ammonium ion derivative 8171
                                      quaternary ammonium ion 5365
                                        tetraethylammonium 17
                                          tetraethylammonium chloride 0
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