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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetraethylammonium
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Accession:CHEBI:44296 term browser browse the term
Definition:A quaternary ammonium ion that has formula C8H20N.
Synonyms:related_synonym: Formula=C8H20N;   InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1;   InChIKey=CBXCPBUEXACCNR-UHFFFAOYSA-N;   N,N,N-triethylethanaminium;   NEt4(+);   SMILES=CC[N+](CC)(CC)CC;   TETRAETHYLAMMONIUM ION;   tetraethylazanium
 alt_id: CHEBI:44295;   CHEBI:9478
 xref: Beilstein:1738225;   CAS:66-40-0;   KEGG:C07512
 xref_mesh: MESH:D019789
 xref: PDBeChem:NET


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tetraethylammonium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp1 aquaporin 1 decreases activity ISO Tetraethylammonium results in decreased activity of AQP1 protein CTD PMID:10779387 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Tetraethylammonium results in decreased activity of BCHE protein CTD PMID:31173753 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP Tetraethylammonium promotes the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone] CTD PMID:18835572 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Kcna1 potassium voltage-gated channel subfamily A member 1 increases response to substance
multiple interactions
affects binding
affects response to substance
ISO KCNA1 protein results in increased susceptibility to Tetraethylammonium
Tetraethylammonium inhibits the reaction [Scorpion Venoms binds to KCNA1 protein]
Tetraethylammonium binds to KCNA1 protein
KCNA1 protein affects the susceptibility to Tetraethylammonium
CTD PMID:12700677 PMID:15100162 PMID:25792741 NCBI chr 4:159,190,781...159,192,526
Ensembl chr 4:159,190,804...159,192,526
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 multiple interactions ISO Tetraethylammonium inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]; Tetraethylammonium inhibits the reaction [estradiol-bovine serum albumin results in increased activity of KCNMA1 protein]; Tetraethylammonium promotes the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]]; Tetraethylammonium results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein] CTD PMID:18068743 PMID:21413024 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956
JBrowse link
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 multiple interactions ISO Tetraethylammonium promotes the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]]; Tetraethylammonium results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein] CTD PMID:21413024 NCBI chr10:18,910,586...18,922,856
Ensembl chr10:18,906,010...18,919,639
JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 multiple interactions ISO [Ionomycin co-treated with Tetraethylammonium] results in increased activity of KCNN4 protein; Clotrimazole inhibits the reaction [[Ionomycin co-treated with Tetraethylammonium] results in increased activity of KCNN4 protein] CTD PMID:14985237 NCBI chr 1:81,227,855...81,245,986
Ensembl chr 1:81,230,612...81,245,996
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
increases import
increases uptake
affects transport
EXP
ISO
1-Methyl-4-phenylpyridinium affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Chlorpheniramine affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Disopyramide affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Dopamine affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Progesterone inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A1 protein results in increased import of Tetraethylammonium; SLC22A1 results in increased import of Tetraethylammonium
3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; 4-biphenylamine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; bis(4-hydroxyphenyl)sulfone promotes the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; bisphenol A inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; bisphenol F inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Nicotine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; tetrabromobisphenol A inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]; Tobacco Smoke Pollution inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]
SLC22A1 protein affects the transport of Tetraethylammonium
CTD PMID:9260930 PMID:9830022 PMID:12440152 PMID:16006492 PMID:16141367 PMID:16142924 PMID:19357179 PMID:21256917 PMID:23850984 PMID:24799337 PMID:25106415 PMID:25862123 PMID:27450509 PMID:27989701 PMID:30189235 PMID:32003934 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a16 solute carrier family 22 member 16 multiple interactions
increases uptake
ISO [Tetraethylammonium results in decreased activity of SLC22A16 protein] which results in decreased susceptibility to Doxorubicin; Dopamine inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]; Guanidine inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]; Lidocaine inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]; N(1)-methylnicotinamide inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]; Procainamide inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]; Serotonin inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium] CTD PMID:15963465 NCBI chr20:45,658,398...45,669,192 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
increases uptake
decreases uptake
increases import
affects transport
ISO
EXP
3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; [Mercuric Chloride results in decreased activity of SLC22A2 protein] which results in decreased uptake of Tetraethylammonium; Aconitine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; bis(4-hydroxyphenyl)sulfone promotes the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; bisphenol F promotes the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Chlorpyrifos inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Cimetidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Famotidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Fenitrothion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Haloperidol inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Lidocaine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Malathion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Mianserin inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Nicotine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; tetrabromobisphenol A inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Tetraethylammonium inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Tetraethylammonium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Tobacco Smoke Pollution inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; Triazolam inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
SLC22A2 gene polymorphism results in decreased uptake of Tetraethylammonium
SLC22A2 protein results in increased import of Tetraethylammonium; SLC22A2 results in increased import of Tetraethylammonium
1-Methyl-4-phenylpyridinium affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Chlorpheniramine affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Corticosterone inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Desoxycorticosterone inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Disopyramide affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Dopamine affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Estradiol affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Progesterone inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Testosterone inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
CTD PMID:9260930 PMID:9830022 PMID:12440152 PMID:15496291 PMID:16006492 PMID:16141367 PMID:17220237 PMID:17287197 PMID:19357179 PMID:21256917 PMID:23770354 PMID:27989701 PMID:28629854 PMID:30189235 PMID:32003934 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
increases uptake
ISO
EXP
Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]; Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]
SLC22A3 protein results in increased uptake of Tetraethylammonium
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; 1-Methyl-4-phenylpyridinium analog inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; 5-dimethylamiloride inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Barium inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Guanidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; N(1)-methylnicotinamide inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Potassium inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Desoxycorticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Dopamine affects the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Estradiol inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Norepinephrine affects the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Progesterone inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Testosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:9830022 PMID:10966924 PMID:16141367 PMID:19357179 PMID:21256917 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions
increases uptake
increases transport
ISO Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Carvedilol inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Diltiazem inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Flecainide inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Ipratropium inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Lidocaine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Nifedipine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Propafenone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Propranolol inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Spironolactone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]; Verapamil inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]
SLC22A4 protein results in increased transport of Tetraethylammonium
CTD PMID:21641380 PMID:25490951 PMID:27504015 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions
increases uptake
EXP 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A5 protein results in increased uptake of Tetraethylammonium]; Carnitine inhibits the reaction [SLC22A5 protein results in increased uptake of Tetraethylammonium]; Tetraethylammonium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:12644265 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc47a1 solute carrier family 47 member 1 affects transport
decreases uptake
increases uptake
multiple interactions
increases import
ISO
EXP
SLC47A1 protein affects the transport of Tetraethylammonium
SLC47A1 protein polymorphism results in decreased uptake of Tetraethylammonium
SLC47A1 protein results in increased uptake of Tetraethylammonium
bis(4-hydroxyphenyl)sulfone inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium]; bisphenol A inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium]; bisphenol F inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium]; Pyrimethamine inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium]; tetrabromobisphenol A inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium]; Tetraethylammonium inhibits the reaction [SLC47A1 protein affects the uptake of Paraquat]; Tetraethylammonium inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Tobacco Smoke Pollution inhibits the reaction [SLC47A1 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC47A1 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium]
CTD PMID:16928787 PMID:17495125 PMID:19172157 PMID:22419765 PMID:27450509 PMID:27989701 PMID:32305507 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions
increases import
increases uptake
ISO Amitriptyline inhibits the reaction [SLC47A2 protein results in increased import of Tetraethylammonium]; Pyrimethamine inhibits the reaction [SLC47A2 protein results in increased uptake of Tetraethylammonium]; Tetraethylammonium inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Tobacco Smoke Pollution inhibits the reaction [SLC47A2 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC47A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:22419765 PMID:27989701 PMID:28629854 PMID:32305507 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    chemical entity 19773
      molecular entity 19771
        ion 15935
          organic ion 8447
            organic cation 7303
              quaternary ammonium ion 5090
                tetraethylammonium 15
                  tetraethylammonium chloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    main group molecular entity 19665
                      s-block molecular entity 19430
                        hydrogen molecular entity 19424
                          hydrides 18758
                            inorganic hydride 17457
                              pnictogen hydride 17432
                                nitrogen hydride 17277
                                  ammonium 8210
                                    ammonium ion derivative 8206
                                      quaternary ammonium ion 5090
                                        tetraethylammonium 15
                                          tetraethylammonium chloride 0
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