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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:metyrapone
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Accession:CHEBI:44241 term browser browse the term
Definition:An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Synonyms:related_synonym: 2-methyl-1,2-dipyridin-3-ylpropan-1-one;   Formula=C14H14N2O;   InChI=1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3;   InChIKey=FJLBFSROUSIWMA-UHFFFAOYSA-N;   Metopiron;   Metopirone;   SMILES=CC(C)(C(=O)c1cccnc1)c1cccnc1;   metirapona;   metyraponum
 alt_id: CHEBI:44238;   CHEBI:6911
 xref: Beilstein:163023;   CAS:54-36-4;   DrugBank:DB01011;   Drug_Central:1791;   KEGG:C07205;   KEGG:D00410;   LINCS:LSM-3035
 xref_mesh: MESH:D008797
 xref: PDBeChem:MYT;   Patent:US2966493;   Reaxys:163023;   Wikipedia:Metyrapone


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metyrapone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions
increases activity
ISO Metyrapone results in increased expression of ABCC3 mRNA
[Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA
Metyrapone results in increased activity of ABCC3 protein
CTD PMID:14570758 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of ATF6 protein] CTD PMID:19819344 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Casp4 caspase 4 multiple interactions ISO [Metyrapone co-treated with Vitamin K 3] affects the localization of CASP4 protein CTD PMID:19819344 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of CCL2 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of CCL2 protein] CTD PMID:27037194 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of CXCL1 protein] CTD PMID:27037194 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA] CTD PMID:16935330 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] CTD PMID:16935330 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein] CTD PMID:11856816 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:18669584 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
EXP Metyrapone inhibits the reaction [CYP2B1 results in increased susceptibility to Cyclophosphamide]; Metyrapone inhibits the reaction [CYP2B1 results in increased susceptibility to Ifosfamide]
Metyrapone results in increased expression of CYP2B1 mRNA
CTD PMID:7834628 PMID:16125621 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Metyrapone results in increased expression of CYP2B2 mRNA CTD PMID:16125621 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions ISO Metyrapone inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein] CTD PMID:11856816 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions
increases expression
ISO [Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
Metyrapone results in increased expression of CYP3A4 mRNA
CTD PMID:10219967 PMID:12505310 PMID:17041008 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [Metyrapone co-treated with Metyrapone] results in increased expression of DDIT3 protein; Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of DDIT3 protein] CTD PMID:19819344 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of Metyrapone CTD PMID:24246760 NCBI chr 6:95,522,577...95,541,393
Ensembl chr 6:95,522,577...95,541,393
JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of HIF3A mRNA] CTD PMID:27037194 NCBI chr 1:78,976,318...78,997,869
Ensembl chr 1:78,976,318...78,997,869
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of HMOX1 mRNA] CTD PMID:27037194 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity ISO Metyrapone results in decreased activity of HSD11B1 protein CTD PMID:10664531 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Metyrapone results in decreased activity of HSD11B2 protein CTD PMID:10664531 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression
multiple interactions
ISO Metyrapone results in decreased expression of HSD17B1 mRNA
[Colforsin co-treated with Metyrapone] results in decreased expression of HSD17B1 mRNA
CTD PMID:16935330 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions
decreases expression
ISO [Colforsin co-treated with Metyrapone] results in decreased expression of HSD3B2 mRNA
Metyrapone results in decreased expression of HSD3B2 mRNA
CTD PMID:16935330 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of HSPA5 protein] CTD PMID:19819344 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of IL10 protein] CTD PMID:27037194 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il17a interleukin 17A multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of IL17A protein] CTD PMID:27037194 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of IL6 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of IL6 protein] CTD PMID:27037194 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lepr leptin receptor increases expression EXP Metyrapone increases Lepr mRNA expression in placenta RGD PMID:12297537 RGD:10412034 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Metyrapone co-treated with Vitamin K 3] results in increased expression of MAP1LC3B protein CTD PMID:19819344 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Metyrapone inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of MT1 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of MT1 mRNA] CTD PMID:27037194 PMID:31520820 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO [Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:14570758 PMID:16919048 PMID:17041008 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Metyrapone results in increased activity of NR1I3 protein CTD PMID:16919048 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pomc proopiomelanocortin increases expression ISO
EXP
Metyrapone results in increased expression of POMC protein CTD PMID:638031 PMID:16566900 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions EXP Metyrapone inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of SGK1 mRNA] CTD PMID:31520820 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Metyrapone inhibits the reaction [Cocaine results in increased expression of TNF protein]
Metyrapone inhibits the reaction [Ozone results in increased expression of TNF mRNA]
CTD PMID:11856816 PMID:27037194 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions EXP Metyrapone inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of TSC22D3 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of TSC22D3 mRNA] CTD PMID:27037194 PMID:31520820 NCBI chr  X:111,884,285...111,944,693
Ensembl chr  X:111,884,295...111,887,906
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      application 19401
        pharmaceutical 19289
          diagnostic agent 729
            metyrapone 34
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      ketone 16824
                                        aromatic ketone 12099
                                          metyrapone 34
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