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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:metyrapone
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Accession:CHEBI:44241 term browser browse the term
Definition:An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Synonyms:related_synonym: 2-methyl-1,2-dipyridin-3-ylpropan-1-one;   Formula=C14H14N2O;   InChI=1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3;   InChIKey=FJLBFSROUSIWMA-UHFFFAOYSA-N;   Metopiron;   Metopirone;   SMILES=CC(C)(C(=O)c1cccnc1)c1cccnc1;   metirapona;   metyraponum
 alt_id: CHEBI:44238;   CHEBI:6911
 xref: Beilstein:163023;   CAS:54-36-4;   DrugBank:DB01011;   Drug_Central:1791;   KEGG:C07205;   KEGG:D00410;   LINCS:LSM-3035
 xref_mesh: MESH:D008797
 xref: PDBeChem:MYT;   Patent:US2966493;   Reaxys:163023;   Wikipedia:Metyrapone



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metyrapone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions
increases activity
ISO Metyrapone results in increased expression of ABCC3 mRNA
[Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA
Metyrapone results in increased activity of ABCC3 protein
CTD PMID:14570758 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of ATF6 protein] CTD PMID:19819344 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Casp4 caspase 4 multiple interactions ISO [Metyrapone co-treated with Vitamin K 3] affects the localization of CASP4 protein CTD PMID:19819344 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of CCL2 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of CCL2 protein] CTD PMID:27037194 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of CXCL1 protein] CTD PMID:27037194 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA] CTD PMID:16935330 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] CTD PMID:16935330 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein] CTD PMID:11856816 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:18669584 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
EXP Metyrapone inhibits the reaction [CYP2B1 results in increased susceptibility to Cyclophosphamide]; Metyrapone inhibits the reaction [CYP2B1 results in increased susceptibility to Ifosfamide]
Metyrapone results in increased expression of CYP2B1 mRNA
CTD PMID:7834628 PMID:16125621 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Metyrapone results in increased expression of CYP2B2 mRNA CTD PMID:16125621 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions ISO Metyrapone inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein] CTD PMID:11856816 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO Metyrapone results in increased expression of CYP3A4 mRNA
[Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:10219967 PMID:12505310 PMID:17041008 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [Metyrapone co-treated with Metyrapone] results in increased expression of DDIT3 protein; Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of DDIT3 protein] CTD PMID:19819344 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of Metyrapone CTD PMID:24246760 NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of HIF3A mRNA] CTD PMID:27037194 NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of HMOX1 mRNA] CTD PMID:27037194 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity ISO Metyrapone results in decreased activity of HSD11B1 protein CTD PMID:10664531 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Metyrapone results in decreased activity of HSD11B2 protein CTD PMID:10664531 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression
multiple interactions
ISO Metyrapone results in decreased expression of HSD17B1 mRNA
[Colforsin co-treated with Metyrapone] results in decreased expression of HSD17B1 mRNA
CTD PMID:16935330 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions
decreases expression
ISO [Colforsin co-treated with Metyrapone] results in decreased expression of HSD3B2 mRNA
Metyrapone results in decreased expression of HSD3B2 mRNA
CTD PMID:16935330 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of HSPA5 protein] CTD PMID:19819344 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of IL10 protein] CTD PMID:27037194 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il17a interleukin 17A multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of IL17A protein] CTD PMID:27037194 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of IL6 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of IL6 protein] CTD PMID:27037194 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lepr leptin receptor increases expression EXP Metyrapone increases Lepr mRNA expression in placenta RGD PMID:12297537 RGD:10412034 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Metyrapone co-treated with Vitamin K 3] results in increased expression of MAP1LC3B protein CTD PMID:19819344 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Metyrapone inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of MT1 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of MT1 mRNA] CTD PMID:27037194 PMID:31520820 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO [Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:14570758 PMID:16919048 PMID:17041008 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Metyrapone results in increased activity of NR1I3 protein CTD PMID:16919048 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Pomc proopiomelanocortin increases expression ISO
EXP
Metyrapone results in increased expression of POMC protein CTD PMID:638031 PMID:16566900 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions EXP Metyrapone inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of SGK1 mRNA] CTD PMID:31520820 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Metyrapone inhibits the reaction [Cocaine results in increased expression of TNF protein]
Metyrapone inhibits the reaction [Ozone results in increased expression of TNF mRNA]
CTD PMID:11856816 PMID:27037194 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions EXP Metyrapone inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of TSC22D3 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of TSC22D3 mRNA] CTD PMID:27037194 PMID:31520820 NCBI chr  X:104,217,898...104,277,935
Ensembl chr  X:104,217,925...104,276,861
JBrowse link

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  CHEBI ontology 20050
    role 20001
      application 19737
        pharmaceutical 19610
          diagnostic agent 731
            metyrapone 34
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic group 18937
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18872
                                    carbonyl compound 18872
                                      ketone 17097
                                        aromatic ketone 12374
                                          metyrapone 34
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