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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(S)-fenfluramine
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Accession:CHEBI:439329 term browser browse the term
Definition:The S-enantiomer of fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike fenfluramine it does not possess catecholamine agonist activity. It was formerly given by mouth as the hydrochloride in the treatment of obesity, but, like fenfluramine, was withdrawn wolrdwide following reports of valvular heart defects.
Synonyms:exact_synonym: (2S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
 related_synonym: (+)-fenfluramine;   (S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine;   Formula=C12H16F3N;   InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3/t9-/m0/s1;   InChIKey=DBGIVFWFUFKIQN-VIFPVBQESA-N;   SMILES=CCN[C@@H](C)Cc1cccc(c1)C(F)(F)F;   d-N-ethyl-alpha-methyl-m-trifluoromethylphenethylamine;   dexfenfluramina;   dexfenfluramine;   dexfenfluraminum;   dextrofenfluramine
 xref: Beilstein:4783710;   CAS:3239-44-9;   DrugBank:DB01191;   Drug_Central:832;   KEGG:D07805;   LINCS:LSM-5685
 xref_mesh: MESH:D020372
 xref: PMID:16257207;   Patent:US3198834
 cyclic_relationship: is_enantiomer_of CHEBI:521051

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(S)-fenfluramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dexfenfluramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects activity ISO Dexfenfluramine affects the activity of SLC6A4 protein CTD PMID:18506000 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        pharmacological role 18821
          neurotransmitter agent 16435
            serotonergic drug 3964
              serotonergic agonist 981
                (S)-fenfluramine 2
                  (S)-fenfluramine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            organic hydride 18265
                              organic fundamental parent 18265
                                hydrocarbon 17986
                                  halohydrocarbon 13958
                                    haloalkane 11674
                                      fluoroalkane 7121
                                        fluoromethanes 6339
                                          tetrafluoromethane 6339
                                            trifluoromethyl group 6339
                                              (trifluoromethyl)benzenes 6339
                                                fenfluramine 8
                                                  (S)-fenfluramine 2
                                                    (S)-fenfluramine hydrochloride 0
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