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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(S)-fenfluramine
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Accession:CHEBI:439329 term browser browse the term
Definition:The S-enantiomer of fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike fenfluramine it does not possess catecholamine agonist activity. It was formerly given by mouth as the hydrochloride in the treatment of obesity, but, like fenfluramine, was withdrawn wolrdwide following reports of valvular heart defects.
Synonyms:exact_synonym: (2S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
 related_synonym: (+)-fenfluramine;   (S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine;   Formula=C12H16F3N;   InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3/t9-/m0/s1;   InChIKey=DBGIVFWFUFKIQN-VIFPVBQESA-N;   SMILES=CCN[C@@H](C)Cc1cccc(c1)C(F)(F)F;   d-N-ethyl-alpha-methyl-m-trifluoromethylphenethylamine;   dexfenfluramina;   dexfenfluramine;   dexfenfluraminum;   dextrofenfluramine
 xref: Beilstein:4783710;   CAS:3239-44-9;   DrugBank:DB01191;   Drug_Central:832;   KEGG:D07805;   LINCS:LSM-5685
 xref_mesh: MESH:D020372
 xref: PMID:16257207;   Patent:US3198834
 cyclic_relationship: is_enantiomer_of CHEBI:521051


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(S)-fenfluramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dexfenfluramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects activity ISO Dexfenfluramine affects the activity of SLC6A4 protein CTD PMID:18506000 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        pharmacological role 19911
          neurotransmitter agent 16947
            serotonergic drug 4420
              serotonergic agonist 1044
                (S)-fenfluramine 2
                  (S)-fenfluramine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            organic hydride 19079
                              organic fundamental parent 19079
                                hydrocarbon 18731
                                  halohydrocarbon 16109
                                    haloalkane 13050
                                      fluoroalkane 9309
                                        fluoromethanes 6826
                                          tetrafluoromethane 6826
                                            trifluoromethyl group 6826
                                              (trifluoromethyl)benzenes 6826
                                                fenfluramine 42
                                                  (S)-fenfluramine 2
                                                    (S)-fenfluramine hydrochloride 0
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