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Accession:CHEBI:439329 term browser browse the term
Definition:The S-enantiomer of fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike fenfluramine it does not possess catecholamine agonist activity. It was formerly given by mouth as the hydrochloride in the treatment of obesity, but, like fenfluramine, was withdrawn wolrdwide following reports of valvular heart defects.
Synonyms:exact_synonym: (2S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
 related_synonym: (+)-fenfluramine;   (S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine;   Formula=C12H16F3N;   InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3/t9-/m0/s1;   InChIKey=DBGIVFWFUFKIQN-VIFPVBQESA-N;   SMILES=CCN[C@@H](C)Cc1cccc(c1)C(F)(F)F;   d-N-ethyl-alpha-methyl-m-trifluoromethylphenethylamine;   dexfenfluramina;   dexfenfluramine;   dexfenfluraminum;   dextrofenfluramine
 xref: Beilstein:4783710 "Beilstein";   CAS:3239-44-9 "ChemIDplus";   DrugBank:DB01191;   Drug_Central:832 "DrugCentral";   KEGG:D07805;   LINCS:LSM-5685
 xref_mesh: MESH:D020372
 xref: PMID:16257207 "ChEMBL";   Patent:US3198834
 cyclic_relationship: is_enantiomer_of CHEBI:521051

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(S)-fenfluramine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc6a4 solute carrier family 6 member 4 JBrowse link 10 63,153,656 63,188,377 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        pharmacological role 18684
          neurotransmitter agent 16233
            serotonergic drug 3846
              serotonergic agonist 878
                (S)-fenfluramine 2
                  (S)-fenfluramine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            organic hydride 17528
                              organic fundamental parent 17528
                                hydrocarbon 16935
                                  alkane 12481
                                    methane 9407
                                      halomethane 9407
                                        fluoromethanes 6272
                                          fluoroform 6272
                                            trifluoromethyl group 6272
                                              (trifluoromethyl)benzenes 6272
                                                fenfluramine 8
                                                  (S)-fenfluramine 2
                                                    (S)-fenfluramine hydrochloride 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.