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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(S)-fenfluramine
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Accession:CHEBI:439329 term browser browse the term
Definition:The S-enantiomer of fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike fenfluramine it does not possess catecholamine agonist activity. It was formerly given by mouth as the hydrochloride in the treatment of obesity, but, like fenfluramine, was withdrawn wolrdwide following reports of valvular heart defects.
Synonyms:exact_synonym: (2S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
 related_synonym: (+)-fenfluramine;   (S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine;   Formula=C12H16F3N;   InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3/t9-/m0/s1;   InChIKey=DBGIVFWFUFKIQN-VIFPVBQESA-N;   SMILES=CCN[C@@H](C)Cc1cccc(c1)C(F)(F)F;   d-N-ethyl-alpha-methyl-m-trifluoromethylphenethylamine;   dexfenfluramina;   dexfenfluramine;   dexfenfluraminum;   dextrofenfluramine
 xref: Beilstein:4783710;   CAS:3239-44-9;   DrugBank:DB01191;   Drug_Central:832;   KEGG:D07805;   LINCS:LSM-5685
 xref_mesh: MESH:D020372
 xref: PMID:16257207;   Patent:US3198834
 cyclic_relationship: is_enantiomer_of CHEBI:521051


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(S)-fenfluramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dexfenfluramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects activity ISO Dexfenfluramine affects the activity of SLC6A4 protein CTD PMID:18506000 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        pharmacological role 19122
          neurotransmitter agent 16811
            serotonergic drug 4341
              serotonergic agonist 1023
                (S)-fenfluramine 2
                  (S)-fenfluramine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    main group molecular entity 19865
                      s-block molecular entity 19697
                        hydrogen molecular entity 19678
                          hydrides 19184
                            organic hydride 18719
                              organic fundamental parent 18719
                                hydrocarbon 18462
                                  halohydrocarbon 15877
                                    haloalkane 12911
                                      fluoroalkane 9226
                                        fluoromethanes 6768
                                          tetrafluoromethane 6768
                                            trifluoromethyl group 6768
                                              (trifluoromethyl)benzenes 6768
                                                fenfluramine 42
                                                  (S)-fenfluramine 2
                                                    (S)-fenfluramine hydrochloride 0
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