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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
ISO |
AKT1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; methyllycaconitine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein] methyllycaconitine results in increased phosphorylation of AKT1 protein |
CTD |
PMID:12511591 PMID:24012499 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
App |
amyloid beta precursor protein |
multiple interactions decreases secretion |
ISO EXP |
methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]; methyllycaconitine inhibits the reaction [N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] methyllycaconitine results in decreased secretion of APP protein [APP protein co-treated with methyllycaconitine] results in decreased secretion of APP protein |
CTD |
PMID:25881725 PMID:29341888 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
ISO |
methyllycaconitine inhibits the reaction [Nicotine results in increased secretion of BDNF protein] |
CTD |
PMID:16790237 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Cd36 |
CD36 molecule |
multiple interactions |
ISO |
methyllycaconitine inhibits the reaction [Varenicline results in increased expression of CD36 mRNA]; methyllycaconitine inhibits the reaction [Varenicline results in increased expression of CD36 protein] |
CTD |
PMID:28202387 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cdh5 |
cadherin 5 |
multiple interactions |
ISO |
methyllycaconitine inhibits the reaction [Varenicline results in decreased expression of CDH5] |
CTD |
PMID:28842382 |
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NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
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G |
Chat |
choline O-acetyltransferase |
multiple interactions |
ISO |
methyllycaconitine inhibits the reaction [SLURP1 protein results in increased expression of CHAT] |
CTD |
PMID:24365495 |
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NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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G |
Chrna2 |
cholinergic receptor nicotinic alpha 2 subunit |
multiple interactions |
EXP |
methyllycaconitine affects binding competes with [Epibatidine binds to Chrna2 protein] |
RGD |
PMID:15016836 |
RGD:2303194 |
NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
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G |
Chrna3 |
cholinergic receptor nicotinic alpha 3 subunit |
affects response to substance multiple interactions |
ISO EXP |
CHRNA3 protein affects the susceptibility to methyllycaconitine methyllycaconitine affects binding [Epibatidine binds to Chrna3 protein] |
CTD RGD |
PMID:19098233 PMID:15016836 |
RGD:2303194 |
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
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G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
multiple interactions affects activity |
ISO EXP |
Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] methyllycaconitine affects the activity of CHRNA4 protein methyllycaconitine affects binding to Chrna4 protein; methyllycaconitine competes with [Epibatidine binds to Chrna4 protein] |
CTD RGD |
PMID:14645658 PMID:19047205 PMID:15016836 |
RGD:2303194 |
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrna5 |
cholinergic receptor nicotinic alpha 5 subunit |
affects response to substance |
ISO |
CHRNA5 protein affects the susceptibility to methyllycaconitine |
CTD |
PMID:19098233 |
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NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146
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G |
Chrna7 |
cholinergic receptor nicotinic alpha 7 subunit |
multiple interactions affects binding affects response to substance |
ISO EXP |
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B mRNA; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B protein; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 mRNA; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 protein; [methyllycaconitine binds to and results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; methyllycaconitine binds to and results in decreased activity of CHRNA7 protein; methyllycaconitine binds to and results in increased activity of CHRNA7 protein; methyllycaconitine inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]; methyllycaconitine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]; methyllycaconitine inhibits the reaction [Choline results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [desnitroimidacloprid results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [epibatidine binds to CHRNA7 protein]; methyllycaconitine inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [PNU-282987 binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [pozanicline binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine promotes the reaction [[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium] methyllycaconitine analog binds to CHRNA7 protein; methyllycaconitine binds to CHRNA7 protein [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which affects the susceptibility to Nicotine; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to bis(12)-hupyridone; methyllycaconitine binds to and results in decreased activity of CHRNA7 protein; methyllycaconitine inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]; methyllycaconitine inhibits the reaction [Melitten results in increased activity of CHRNA7 protein]; Nicotine inhibits the reaction [methyllycaconitine binds to CHRNA7 protein] [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; methyllycaconitine binds to and results in decreased activity of CHRNA7 protein; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]; methyllycaconitine inhibits the reaction [N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] CHRNA7 protein affects the susceptibility to methyllycaconitine |
CTD |
PMID:9336329 PMID:10082212 PMID:10216184 PMID:11893908 PMID:12626641 PMID:15523001 PMID:15542623 PMID:17098430 PMID:17218065 PMID:17498763 PMID:17709503 PMID:18321476 PMID:18385335 PMID:18448488 PMID:19098233 PMID:19448648 PMID:19498423 PMID:19910175 PMID:21051662 PMID:21385097 PMID:21703337 PMID:21715663 PMID:23085120 PMID:25881725 PMID:28395994 PMID:34628512 More...
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NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
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G |
Chrna9 |
cholinergic receptor nicotinic alpha 9 subunit |
multiple interactions |
ISO |
methyllycaconitine binds to and results in decreased activity of CHRNA9 protein |
CTD |
PMID:25282151 |
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NCBI chr14:42,235,218...42,241,939
Ensembl chr14:42,235,226...42,242,192
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G |
Chrnb2 |
cholinergic receptor nicotinic beta 2 subunit |
multiple interactions |
ISO EXP |
Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] methyllycaconitine affects binding to Chrnb2 protein; methyllycaconitine competes with [Epibatidine binds to Chrnb2 protein] |
CTD RGD |
PMID:14645658 PMID:15016836 |
RGD:2303194 |
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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G |
Dbh |
dopamine beta-hydroxylase |
multiple interactions |
ISO |
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA] |
CTD |
PMID:17498763 |
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NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO |
methyllycaconitine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein] |
CTD |
PMID:34784199 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
methyllycaconitine inhibits the reaction [N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide inhibits the reaction [Estradiol affects the expression of IL1B mRNA]] |
CTD |
PMID:27766701 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1r1 |
interleukin 1 receptor type 1 |
multiple interactions |
EXP |
methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 mRNA]; methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 protein] |
CTD |
PMID:27180639 |
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NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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G |
Il6 |
interleukin 6 |
increases expression |
ISO |
methyllycaconitine results in increased expression of IL6 protein |
CTD |
PMID:25396421 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itga2b |
integrin subunit alpha 2b |
multiple interactions |
ISO |
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B mRNA; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B protein |
CTD |
PMID:21385097 |
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NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
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G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
methyllycaconitine inhibits the reaction [4-naphthalene-1-yl-3a,4,5,9b-tetrahydro-3-H-cyclopenta(c)quinoline-8-sulfonic acid amide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ITGAM mRNA]] |
CTD |
PMID:28867753 |
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NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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G |
Itgb3 |
integrin subunit beta 3 |
multiple interactions |
ISO |
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 mRNA; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 protein |
CTD |
PMID:21385097 |
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NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; MAPK1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of MAPK1 protein] methyllycaconitine results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:18448488 PMID:24012499 PMID:28202387 PMID:28842382 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO |
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; MAPK3 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of MAPK3 protein] methyllycaconitine results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:18448488 PMID:24012499 PMID:28202387 PMID:28842382 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Marcks |
myristoylated alanine rich protein kinase C substrate |
increases phosphorylation |
ISO |
methyllycaconitine results in increased phosphorylation of MARCKS protein |
CTD |
PMID:24012499 |
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NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein] |
CTD |
PMID:29501575 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mtor |
mechanistic target of rapamycin kinase |
increases phosphorylation multiple interactions |
ISO |
methyllycaconitine results in increased phosphorylation of MTOR protein MTOR mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein] |
CTD |
PMID:24012499 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP |
methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]] |
CTD |
PMID:27984197 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
methyllycaconitine inhibits the reaction [4-naphthalene-1-yl-3a,4,5,9b-tetrahydro-3-H-cyclopenta(c)quinoline-8-sulfonic acid amide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NFKBIA mRNA]] |
CTD |
PMID:28867753 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Ntrk2 |
neurotrophic receptor tyrosine kinase 2 |
multiple interactions |
ISO |
methyllycaconitine inhibits the reaction [Nicotine results in increased expression of NTRK2 protein] |
CTD |
PMID:16790237 |
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NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
multiple interactions |
ISO |
methyllycaconitine inhibits the reaction [Varenicline results in increased expression of OLR1 mRNA]; methyllycaconitine inhibits the reaction [Varenicline results in increased expression of OLR1 protein] |
CTD |
PMID:28202387 |
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NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of RELA protein] methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]] |
CTD |
PMID:27984197 PMID:28202387 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Slurp1 |
secreted Ly6/Plaur domain containing 1 |
multiple interactions |
ISO |
methyllycaconitine inhibits the reaction [SLURP1 protein results in increased abundance of Acetylcholine]; methyllycaconitine inhibits the reaction [SLURP1 protein results in increased expression of CHAT] |
CTD |
PMID:24365495 |
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NCBI chr 7:106,611,949...106,613,365
Ensembl chr 7:106,611,949...106,613,365
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G |
Srr |
serine racemase |
multiple interactions increases expression |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; [methyllycaconitine co-treated with Egtazic Acid] results in increased expression of SRR protein; AKT1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; Cycloheximide inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; MAPK1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; MAPK3 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; MTOR mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; Sirolimus inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; U 0126 inhibits the reaction [methyllycaconitine results in increased expression of SRR protein] [methyllycaconitine co-treated with Egtazic Acid] results in increased expression of SRR protein; Cycloheximide inhibits the reaction [methyllycaconitine results in increased expression of SRR protein] |
CTD |
PMID:24012499 |
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NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions decreases phosphorylation |
ISO EXP |
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] methyllycaconitine results in decreased phosphorylation of STAT3 protein methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form] |
CTD |
PMID:18448488 PMID:25396421 PMID:29501575 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tacr1 |
tachykinin receptor 1 |
multiple interactions |
EXP |
methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 protein] |
CTD |
PMID:26524655 |
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NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
ISO |
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA] |
CTD |
PMID:17498763 |
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NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
ISO |
methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]] methyllycaconitine results in increased expression of TNF protein |
CTD |
PMID:21606497 PMID:25396421 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
multiple interactions |
EXP |
methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 protein] |
CTD |
PMID:26524655 |
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NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
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G |
Txn1 |
thioredoxin 1 |
multiple interactions |
EXP |
methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TXN1 protein] |
CTD |
PMID:28082123 |
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NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Zfp36 |
zinc finger protein 36 |
multiple interactions |
ISO |
methyllycaconitine inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA] |
CTD |
PMID:21606497 |
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NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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