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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(S)-alpha-methyl-4-carboxyphenylglycine
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Accession:CHEBI:43876 term browser browse the term
Definition:A non-proteinogenic alpha-amino acid that is alanine in which the alpha-hydrogen is replaced by a 4-carboxyphenyl group (the S-enantiomer). It is a non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist.
Synonyms:related_synonym: (+)-MCPG;   (+)-alpha-methyl-4-carboxyphenylglycine;   (S)-(+)-alpha-amino-4-carboxy-2-methylbenzeneacetic;   (S)-MCPG;   (S)-a-methyl-4-carboxyphenylglycine;   4-[(1S)-1-amino-1-carboxyethyl]benzoic acid;   Formula=C10H11NO4;   InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1;   InChIKey=DNCAZYRLRMTVSF-JTQLQIEISA-N;   SMILES=C[C@@](N)(C(O)=O)c1ccc(cc1)C(O)=O
 xref: PDBeChem:MCG;   Reaxys:7568949


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(S)-alpha-methyl-4-carboxyphenylglycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcg protein kinase C, gamma multiple interactions EXP (S)-alpha-methyl-4-carboxyphenylglycine inhibits the reaction [long-term potentiation affects localization of Prkcg protein in hippocampus] RGD PMID:10501452 RGD:28867228 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
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Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        pharmacological role 18833
          antagonist 16278
            metabotropic glutamate receptor antagonist 34
              (S)-alpha-methyl-4-carboxyphenylglycine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic group 18603
                              organic divalent group 18594
                                organodiyl group 18594
                                  carbonyl group 18507
                                    carbonyl compound 18507
                                      carboxylic acid 18159
                                        amino acid 14111
                                          alpha-amino acid 11596
                                            non-proteinogenic alpha-amino acid 1558
                                              (S)-alpha-methyl-4-carboxyphenylglycine 1
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