The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Synonyms:
exact_synonym:
5-(1,4-diazepan-1-ylsulfonyl)isoquinoline
related_synonym:
1-(5-isoquinolinesulfonyl)homopiperazine; 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]isoquinoline; AT 877; Formula=C14H17N3O2S; HA 1077; HA1077; InChI=1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2; InChIKey=NGOGFTYYXHNFQH-UHFFFAOYSA-N; SMILES=O=S(=O)(N1CCCNCC1)C1=CC=CC2=C1C=CN=C2; ZK-258594; fasudilum; hexahydro-1-(5-isoquinolinesulfonyl)-1H-1,4-diazepine; hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine
fasudil inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; fasudil inhibits the reaction [Streptozocin results in increased expression of BAX protein]
fasudil inhibits the reaction [Paraquat results in decreased expression of BCL2 mRNA]; fasudil inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] fasudil results in increased expression of BCL2 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP protein]; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP mRNA; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP protein
fasudil inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; fasudil inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]
fasudil results in decreased expression of CFL1 mRNA fasudil inhibits the reaction [Streptozocin results in increased phosphorylation of CFL1 protein] fasudil results in decreased expression of and results in decreased phosphorylation of CFL1 protein
fasudil results in decreased expression of COL1A1 mRNA 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of COL1A1 mRNA]; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of COL1A1 mRNA
fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of IL1B protein]; fasudil inhibits the reaction [Paraquat results in increased expression of IL1B protein] fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; fasudil inhibits the reaction [Paraquat results in increased secretion of IL1B protein] fasudil inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]
fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of IL6 protein]; fasudil inhibits the reaction [Paraquat results in increased expression of IL6 protein] fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; fasudil inhibits the reaction [Paraquat results in increased secretion of IL6 protein] fasudil inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]
fasudil inhibits the reaction [Streptozocin results in decreased expression of NFKBIA protein] fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein]
fasudil inhibits the reaction [Norepinephrine results in increased phosphorylation of PPP1R12A protein]; fasudil inhibits the reaction [Paraquat results in increased phosphorylation of PPP1R12A protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of PPP1R12A protein modified form]
fasudil inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of RELA protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of and affects the localization of RELA protein] fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO protein] fasudil inhibits the reaction [Paraquat results in increased expression of RHO protein] fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO protein]; fasudil inhibits the reaction [Paraquat results in increased expression of RHO protein]
fasudil results in decreased expression of RHOA mRNA; fasudil results in decreased expression of RHOA protein fasudil inhibits the reaction [Acetaminophen results in increased expression of RHOA protein]
fasudil results in decreased expression of ROCK1 mRNA; fasudil results in decreased expression of ROCK1 protein fasudil inhibits the reaction [Acetaminophen results in increased expression of ROCK1 protein]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 protein] fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 protein]; fasudil inhibits the reaction [Paraquat results in increased expression of ROCK1 protein] fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA]; fasudil inhibits the reaction [Paraquat results in increased expression of ROCK1 protein]; fasudil inhibits the reaction [Streptozocin results in increased activity of ROCK1 protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of ROCK1 mRNA]
fasudil results in decreased activity of ROCK2 protein fasudil inhibits the reaction [Acetaminophen results in increased expression of ROCK2 protein]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK2 mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK2 protein]
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 protein]; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 mRNA; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 protein
fasudil inhibits the reaction [Rotenone results in decreased expression of SYP mRNA]; fasudil inhibits the reaction [Streptozocin results in decreased expression of SYP mRNA]; fasudil inhibits the reaction [Streptozocin results in decreased expression of SYP protein]
fasudil affects the expression of TNF mRNA fasudil inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; fasudil inhibits the reaction [Paraquat results in increased secretion of TNF protein] fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of TNF protein]; fasudil inhibits the reaction [Paraquat results in increased expression of TNF protein]
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